|AlignmentProject
obj|Project|2
obj|MolList|2
obj|Object*|191
obj|IxMolX
obj|Molecule
obj|BioObject
obj|DBObj||\28:aotvoCD45_D2 (AAM48512) (3')|||||302453330|0|\36:CD45 phosphatase [Aotus vociferans].
end|2|2|
obj|String*|0
end
obj|String*|1|\31:Method: conceptual translation.
end
obj|String*|10|\34:REFERENCE   1  (residues 1 to 365)|\56:  AUTHORS   Montoya,G.E., Vernot,J.P. and Patarroyo,M.E.|\76:  TITLE     Partial characterization of the CD45 phosphatase cDNA in the owl|\35:            monkey Aotus vociferans|\23:  JOURNAL   Unpublished|\34:REFERENCE   2  (residues 1 to 365)|\56:  AUTHORS   Montoya,G.E., Vernot,J.P. and Patarroyo,M.E.|\29:  TITLE     Direct Submission|\75:  JOURNAL   Submitted (26-MAR-2001) Fisiologia Molecular, FIDIC, Avenida El|\58:            Dorado, Carrera 50. INEA, Bogota, DC, Colombia
end
obj|Object*|0
end
obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp
end
obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/
end
end|1|0|300
obj|Object*|2
obj|Feature
obj|DBObj||Source_1|||||0|0|
end|269|269|||0|1|300|1|1|1|1|1..365
obj|String*|2|\28:/organism="Aotus vociferans"|\22:/db_xref="taxon:57176"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||Protein_1|||||0|0|
end|270|270|||0|1|300|1|1|1|1|<1..>365
obj|String*|1|\27:/product="CD45 phosphatase"
end|0||
obj|Object*|0
end
end
end|\300:nmkkrdppsepspleaefqrlpsyrswrtqhignqeenksknrnsnvipydfnrvplkhelemskesehdsdessdddsdseexskyinasfimxxwkpevmiaaqgplxetigdfwqmifqrkvkvivmltelkhgdqeicaqywgegkqtygdievdlkdtdksstytlrvfelrhskrkdsrtvyqyqytnwsvxxlpaxpkelismiqvxkqklpqknssegnkxhksxpllihcrdgsqqtgifcallnllesaeteevvdxfqvvkalrkarpgmxstfeqxqflydxiastyp|GenPept|
obj|String*|1|AAM48512
end||07-JUN-2002|\37:Aotus vociferans (noisy night monkey)
obj|String*|0
end|0
obj|String*|0
end|PRT
obj|String*|0
end
obj|String*|1|Aotus vociferans
end
obj|String*|0
end
obj|String*|0
end
obj|String*|13|Eukaryota|Metazoa|Chordata|Craniata|Vertebrata|Euteleostomi|Mammalia|Eutheria|Primates|Platyrrhini|Cebidae|Aotinae|Aotus
end
obj|Object*|0
end
obj|String*|0
end
obj|String*|0
end
obj|String*|1|\37:locus AF364095S2 accession AF364096.1
end
obj|String*|15|\60:VNTI URL:vnti:protein/aotvoCD45_D2+%28AAM48512%29+%283%27%29|\60:VNTI URL:vnti:protein/aotvoCD45_D2+%28AAM48512%29+%283%27%29|\60:VNTI URL:vnti:protein/aotvoCD45_D2+%28AAM48512%29+%283%27%29|\60:VNTI URL:vnti:protein/aotvoCD45_D2+%28AAM48512%29+%283%27%29|\60:VNTI URL:vnti:protein/aotvoCD45_D2+%28AAM48512%29+%283%27%29|\60:VNTI URL:vnti:protein/aotvoCD45_D2+%28AAM48512%29+%283%27%29|\60:VNTI URL:vnti:protein/aotvoCD45_D2+%28AAM48512%29+%283%27%29|\60:VNTI URL:vnti:protein/aotvoCD45_D2+%28AAM48512%29+%283%27%29|\60:VNTI URL:vnti:protein/aotvoCD45_D2+%28AAM48512%29+%283%27%29|\60:VNTI URL:vnti:protein/aotvoCD45_D2+%28AAM48512%29+%283%27%29|\60:VNTI URL:vnti:protein/aotvoCD45_D2+%28AAM48512%29+%283%27%29|\60:VNTI URL:vnti:protein/aotvoCD45_D2+%28AAM48512%29+%283%27%29|\60:VNTI URL:vnti:protein/aotvoCD45_D2+%28AAM48512%29+%283%27%29|\60:VNTI URL:vnti:protein/aotvoCD45_D2+%28AAM48512%29+%283%27%29|\60:VNTI URL:vnti:protein/aotvoCD45_D2+%28AAM48512%29+%283%27%29
end
obj|String*|0
end
obj|String*|0
end
end|FBB7B0
end
obj|IxMolX
obj|Molecule
obj|BioObject
obj|DBObj||\22:bIA2_D1 (P56722) Ptprn|||||302454273|0|\94:Protein-tyrosine phosphatase-like N precursor (R-PTP-N) (Islet cell autoantigen 512) (ICA512).
end|2|2|
obj|String*|4|Receptor|Glycoprotein|Signal|Transmembrane
end
obj|String*|21|\67:-------------------------------------------------------------------|\60:This SWISS-PROT entry is copyright. It is produced through a|\63:collaboration between the Swiss Institute of Bioinformatics and|\60:the EMBL outstation - the European Bioinformatics Institute.|\63:The original entry is available from http://www.expasy.ch/sprot|\30:and http://www.ebi.ac.uk/sprot|\67:------------------------------------------------------------------.|\67:[FUNCTION] Implicated in neuroendocrine secretory processes. May be|\67:involved in processes specific for neurosecretory granules, such as|\67:their biogenesis, trafficking or regulated exocytosis or may have a|\64:general role in neuroendocrine functions. Lacks intrinsic enzyme|\65:activity. May play a role in the regulation of secretory granules|\47:via its interaction with SNTB2 (By similarity).|\65:[SUBUNIT] Interacts with phosphorylated SNTB2, protecting it from|\66:protein cleavage by CAPN1. Dephosphorylation of SNTB2 upon insulin|\64:stimulation disrupts the interaction and results in its cleavage|(By similarity).|\62:[SUBCELLULAR LOCATION] Type I membrane protein. Neuroendocrine|secretory granules.|\21:[PTM] N-glycosylated.|\60:[SIMILARITY] CONTAINS 1 PROTEIN-TYROSINE PHOSPHATASE DOMAIN.
end
obj|String*|12|\34:REFERENCE   1  (residues 1 to 979)|\50:  AUTHORS   Hermel,J.-M., Dirkx,R. and Solimena,M.|\29:  TITLE     Direct Submission|\33:  JOURNAL   Submitted (~JUN-1999)|\30:  REMARK    SEQUENCE FROM N.A.|\34:REFERENCE   2  (residues 1 to 979)|\53:  AUTHORS   Hermel,J.M., Dirkx,R. Jr. and Solimena,M.|\75:  TITLE     Post-translational modifications of ICA512, a receptor tyrosine|\58:            phosphatase-like protein of secretory granules|\54:  JOURNAL   Eur. J. Neurosci. 11 (8), 2609-2620 (1999)|  MEDLINE   99388259|\57:  REMARK    SEQUENCE OF N-TERMINUS, AND CHARACTERIZATION.
end
obj|Object*|0
end
obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp
end
obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/
end
end|1|0|279
obj|Object*|6
obj|Feature
obj|DBObj||Source_1|||||0|0|
end|269|269|||0|1|279|1|1|1|1|1..979
obj|String*|2|\22:/organism="Bos taurus"|\21:/db_xref="taxon:9913"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||PTPRN|||||0|0|
end|270|270|||0|1|279|1|1|1|1|1..979
obj|String*|2|/gene="PTPRN"|\56:/product="Protein-tyrosine phosphatase-like N precursor"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||PTPRN|||||0|0|\36:PROTEIN-TYROSINE PHOSPHATASE-LIKE N.
end|203|203|||0|1|279|1|1|1|1|35..979
obj|String*|2|/gene="PTPRN"|\27:/region_name="Mature chain"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||PTPRN|||||0|0|\24:CYTOPLASMIC (POTENTIAL).
end|1004|1004|||0|1|279|1|1|1|1|601..979
obj|String*|2|/gene="PTPRN"|\21:/region_name="Domain"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||PTPRN|||||0|0|\34:PROTEIN-TYROSINE PHOSPHATASE-LIKE.
end|1000|1000|||0|4|279|1|1|1|1|696..979
obj|String*|2|/gene="PTPRN"|\21:/region_name="Domain"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||PTPRN|||||0|0|BY SIMILARITY.
end|220|220|||0|217|217|1|1|1|1|909
obj|String*|2|/gene="PTPRN"|/site_type="active"
end|0||
obj|Object*|0
end
end
end|\279:hmilaymedhlrnrdrlakewqalcayqaepntcataqgegnikknrhpdflpydhariklkvesspsrsdyinaspiiehdprmpayiatqgplshtiadfwqmvwesgctvivmltplvedgvkqcdrywpdegsslyhvyevnlvsehiwcedflvrsfylknvqtqetrtltqfhflswpaegtpastrplldfrrkvnkcyrgrscpiivhcsdgagrtgtyilidmvlnrmakgvkeidiaatlehvrdqrpglvrskdqfefaltavaeevn|GenPept|
obj|String*|1|P56722
end||15-JUN-2002|Bos taurus (cow)
obj|String*|0
end|0
obj|String*|0
end|PRT
obj|String*|1| PTPRN
end
obj|String*|1|Bos taurus
end
obj|String*|0
end
obj|String*|0
end
obj|String*|15|Eukaryota|Metazoa|Chordata|Craniata|Vertebrata|Euteleostomi|Mammalia|Eutheria|Cetartiodactyla|Ruminantia|Pecora|Bovoidea|Bovidae|Bovinae|Bos
end
obj|Object*|0
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obj|String*|0
end
obj|String*|0
end
obj|String*|9|\46:swissprot: locus PTPN_BOVIN, accession P56722;|class: standard.|\22:created: May 30, 2000.|\31:sequence updated: May 30, 2000.|\33:annotation updated: Jun 15, 2002.|\31:xrefs: gi: 5305475, gi: 5305476|\62:xrefs (non-sequence databases): HSSPQ06124, InterProIPR000387,|\60:InterProIPR000242, PfamPF00102, PRINTSPR00700, SMARTSM00194,|\46:PROSITEPS00383, PROSITEPS50056, PROSITEPS50055
end
obj|String*|33|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29|\42:VNTI URL:vnti:protein/bIA2_D1+%28P56722%29
end
obj|String*|0
end
obj|String*|0
end
end|33549E8
end
obj|IxMolX
obj|Molecule
obj|BioObject
obj|DBObj||\30:bPTPBA14_D1 (NP_777015) PTPN13|||||307067825|0|\106:protein tyrosine phosphatase, non-receptor type 13 [APO-1/CD95 (Fas)-associated phosphatase] [Bos taurus].
end|2|2|
obj|String*|0
end
obj|String*|2|\65:PROVISIONAL REFSEQ: This record has not yet been subject to final|\62:NCBI review. The reference sequence was derived from U20807.1.
end
obj|String*|4|\35:REFERENCE   1  (residues 1 to 2484)|\49:  AUTHORS   Vega,Q.C., Walton,K.M. and Dixon,J.E.|\54:  TITLE     Tyrosine Phosphatases and the Cytoskeleton|\23:  JOURNAL   Unpublished
end
obj|Object*|0
end
obj|CreatorData|||||\28:jannik@noergaardandersen.com|||JNA||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp
end
obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/
end
end|1|0|275
obj|Object*|3
obj|Feature
obj|DBObj||Source_1|||||0|0|
end|269|269|||0|1|275|1|1|1|1|1..275
obj|String*|4|\22:/organism="Bos taurus"|\21:/db_xref="taxon:9913"|/chromosome="6"|/map="6"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||Protein_1|||||0|0|
end|270|270|||0|1|275|1|1|1|1|1..275
obj|String*|2|\57:/product="protein tyrosine phosphatase, non-receptor type|\45:13 [APO-1/CD95 (Fas)-associated phosphatase]"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||Region_2|||||0|0|PTPc
end|266|266|||0|20|274|1|1|1|1|20..274
obj|String*|3|\53:/region_name="Protein tyrosine phosphatase, catalytic|domain"|\25:/db_xref="CDD:smart00194"
end|0||
obj|Object*|0
end
end
end|\275:aklksvirmlrglldqgipskelenlqelkpldqcligqtkenrrknryknilpydatrvplgdeggyinasfikipvgreefvyiacqgplpttvgdfwqmiweqnssviammtqevegekikcqrywpnvlgkstmvsnrlrlalvrvqqlkgfvvramtlediqtgevrhvshlnftawpdhdtpsqpddlltfisymrhvhrsgpiithcsagigrsgtlicidvvlglisqdlefdisdlvrcmrlqrhgmvqtedqyifcyqvilyvlt|GenPept|
obj|String*|1|NP_777015
end||2-JUL-2003|Bos taurus (cow).
obj|String*|0
end|0
obj|String*|0
end|PRT
obj|String*|0
end
obj|String*|1|Bos taurus
end
obj|String*|0
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obj|String*|0
end
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end
obj|Object*|0
end
obj|String*|0
end
obj|String*|0
end
obj|String*|1|\29:REFSEQ: accession NM_174590.1
end
obj|String*|37|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13|\56:VNTI URL:vnti:protein/bPTPBA14_D1+%28NP_777015%29+PTPN13
end
obj|String*|0
end
obj|String*|0
end
end|2901148
end
obj|IxMolX
obj|Molecule
obj|BioObject
obj|DBObj||cCD45_D1 (A54080)|||||302463475|0|\84:protein-tyrosine-phosphatase (EC 3.1.3.48), receptor type delta precursor - chicken.
end|2|2|
obj|String*|3|phosphoprotein|\30:phosphoric monoester hydrolase|\29:tyrosine-specific phosphatase
end
obj|String*|0
end
obj|String*|6|\35:REFERENCE   1  (residues 1 to 1237)|\58:  AUTHORS   Fang,K.S., Barker,K., Sudol,M. and Hanafusa,H.|\79:  TITLE     A transmembrane protein-tyrosine phosphatase contains spectrin-like|\47:            repeats in its extracellular domain|\55:  JOURNAL   J. Biol. Chem. 269 (19), 14056-14063 (1994)|  MEDLINE   94245724
end
obj|Object*|0
end
obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp
end
obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/
end
end|1|0|279
obj|Object*|6
obj|Feature
obj|DBObj||Source_1|||||0|0|
end|269|269|||0|1|279|1|1|1|1|1..1237
obj|String*|2|\25:/organism="Gallus gallus"|\21:/db_xref="taxon:9031"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||Protein_1|||||0|0|
end|270|270|||0|1|279|1|1|1|1|1..1237
obj|String*|3|\53:/product="protein-tyrosine-phosphatase, receptor type|delta precursor"|\21:/EC_number="3.1.3.48"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||LAC|||||0|0|\61:leukocyte common antigen cytosolic domain homology #label LAC
end|1000|1000|||0|1|279|1|1|1|1|528..1170
obj|String*|1|\21:/region_name="domain"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||PTP|||||0|0|\48:protein-tyrosine-phosphatase homology #label PTP
end|1000|1000|||0|42|266|1|1|1|1|610..834
obj|String*|1|\21:/region_name="domain"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||Active_Site_1|||||0|0|\34:Cys (phosphocysteine intermediate)
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obj|Feature
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obj|String*|1|A54080
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obj|String*|0
end|0
obj|String*|0
end|PRT
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obj|String*|9|pir: locus A54080;|\61:summary: #length 1237 #molecular-weight 139319 #checksum 1986|;|\63:superfamily: leukocyte common antigen; leukocyte common antigen|\64:cytosolic domain homology; protein-tyrosine-phosphatase homology|;|\66:PIR dates: 02-Aug-1994 #sequence_revision 02-Aug-1994 #text_change|21-Jan-2000|.
end
obj|String*|48|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D1+%28A54080%29
end
obj|String*|0
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end|270C440
end
obj|IxMolX
obj|Molecule
obj|BioObject
obj|DBObj||cCD45_D2 (A54080)|||||302464996|0|\84:protein-tyrosine-phosphatase (EC 3.1.3.48), receptor type delta precursor - chicken.
end|2|2|
obj|String*|3|phosphoprotein|\30:phosphoric monoester hydrolase|\29:tyrosine-specific phosphatase
end
obj|String*|0
end
obj|String*|6|\35:REFERENCE   1  (residues 1 to 1237)|\58:  AUTHORS   Fang,K.S., Barker,K., Sudol,M. and Hanafusa,H.|\79:  TITLE     A transmembrane protein-tyrosine phosphatase contains spectrin-like|\47:            repeats in its extracellular domain|\55:  JOURNAL   J. Biol. Chem. 269 (19), 14056-14063 (1994)|  MEDLINE   94245724
end
obj|Object*|0
end
obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp
end
obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/
end
end|1|0|308
obj|Object*|3
obj|Feature
obj|DBObj||Source_1|||||0|0|
end|269|269|||0|1|308|1|1|1|1|1..1237
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obj|Feature
obj|DBObj||Protein_1|||||0|0|
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obj|String*|3|\53:/product="protein-tyrosine-phosphatase, receptor type|delta precursor"|\21:/EC_number="3.1.3.48"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||LAC|||||0|0|\61:leukocyte common antigen cytosolic domain homology #label LAC
end|1000|1000|||0|1|308|1|1|1|1|528..1170
obj|String*|1|\21:/region_name="domain"
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end||21-JAN-2000|\23:Gallus gallus (chicken)
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end|0
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obj|String*|9|pir: locus A54080;|\61:summary: #length 1237 #molecular-weight 139319 #checksum 1986|;|\63:superfamily: leukocyte common antigen; leukocyte common antigen|\64:cytosolic domain homology; protein-tyrosine-phosphatase homology|;|\66:PIR dates: 02-Aug-1994 #sequence_revision 02-Aug-1994 #text_change|21-Jan-2000|.
end
obj|String*|15|\43:VNTI URL:vnti:protein/cCD45_D2+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D2+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D2+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D2+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D2+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D2+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D2+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D2+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D2+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D2+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D2+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D2+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D2+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D2+%28A54080%29|\43:VNTI URL:vnti:protein/cCD45_D2+%28A54080%29
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obj|String*|0
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obj|String*|0
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end|FB7768
end
obj|IxMolX
obj|Molecule
obj|BioObject
obj|DBObj||cPTP1B_D1 (O13016)|||||302464650|0|\101:Protein-tyrosine phosphatase, non-receptor type 1 (Protein-tyrosine phosphatase 1B) (PTP-1B) (CPTP1).
end|2|2|
obj|String*|1|Hydrolase
end
obj|String*|14|\67:-------------------------------------------------------------------|\60:This SWISS-PROT entry is copyright. It is produced through a|\63:collaboration between the Swiss Institute of Bioinformatics and|\60:the EMBL outstation - the European Bioinformatics Institute.|\63:The original entry is available from http://www.expasy.ch/sprot|\30:and http://www.ebi.ac.uk/sprot|\67:------------------------------------------------------------------.|\65:[CATALYTIC ACTIVITY] PROTEIN TYROSINE PHOSPHATE + H(2)O = PROTEIN|\26:TYROSINE + ORTHOPHOSPHATE.|\66:[SUBCELLULAR LOCATION] ASSOCIATED TO THE ENDOPLASMIC RETICULUM VIA|\66:ITS C-TERMINAL DOMAIN WITH ITS PHOSPHATASE DOMAIN ORIENTED TOWARDS|\30:THE CYTOPLASM (BY SIMILARITY).|\53:[SIMILARITY] BELONGS TO THE NON-RECEPTOR CLASS OF THE|\36:PROTEIN-TYROSINE PHOSPHATASE FAMILY.
end
obj|String*|16|\34:REFERENCE   1  (residues 1 to 434)|\70:  AUTHORS   Balsamo,J., Leung,T., Ernst,H., Zanin,M.K., Hoffman,S. and|\21:            Lilien,J.|\78:  TITLE     Regulated binding of PTP1B-like phosphatase to N-cadherin: control|\78:            of cadherin-mediated adhesion by dephosphorylation of beta-catenin|\49:  JOURNAL   J. Cell Biol. 134 (3), 801-813 (1996)|  MEDLINE   96326683|\30:  REMARK    SEQUENCE FROM N.A.|\25:            TISSUE=Retina|\34:REFERENCE   2  (residues 1 to 434)|\46:  AUTHORS   Kim,C.W., Jung,E.J. and Kang,Y.-S.|\70:  TITLE     Cloning and characterization of a chicken protein tyrosine|\30:            phosphatase, CPTP1|\45:  JOURNAL   Exp. Mol. Med. 28, 207-213 (1996)|\40:  REMARK    SEQUENCE OF 14-369 FROM N.A.|\28:            TISSUE=Intestine
end
obj|Object*|0
end
obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp
end
obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/
end
end|1|0|279
obj|Object*|6
obj|Feature
obj|DBObj||Source_1|||||0|0|
end|269|269|||0|1|279|1|1|1|1|1..434
obj|String*|2|\25:/organism="Gallus gallus"|\21:/db_xref="taxon:9031"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||PTPN1|||||0|0|
end|270|270|||0|1|279|1|1|1|1|1..434
obj|String*|4|/gene="PTPN1"|\57:/product="Protein-tyrosine phosphatase, non-receptor type|1"|\21:/EC_number="3.1.3.48"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||PTPN1|||||0|0|A -> R (IN REF. 2).
end|240|240|||0|14|14|1|1|1|1|14
obj|String*|2|/gene="PTPN1"|\23:/region_name="Conflict"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||PTPN1|||||0|0|\29:PROTEIN-TYROSINE PHOSPHATASE.
end|1000|1000|||0|40|279|1|1|1|1|40..288
obj|String*|2|/gene="PTPN1"|\21:/region_name="Domain"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||PTPN1|||||0|0|\21:GD -> RC (IN REF. 2).
end|240|240|||0|62|63|1|1|1|1|62..63
obj|String*|2|/gene="PTPN1"|\23:/region_name="Conflict"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||PTPN1|||||0|0|
end|220|220|||0|215|215|1|1|1|1|215
obj|String*|2|/gene="PTPN1"|/site_type="active"
end|0||
obj|Object*|0
end
end
end|\279:meiekefhrldqaaswaaiyqdirheasdfpckvakhprnknrnryrdvspfdhsriklnqgdndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvvmlnrvmekgsikcaqywprkeekemffedtnlkltlisediksyytvrqlelenlttqetreilhfhyttwpdfgvpespasflnflfkvresgslnpeygpvvvhcsagigrsgtfclvdtclllmdkrkdpssvdvkqvllemrkyrmgliqtadqlrfsylaviegak|GenPept|
obj|String*|1|O13016
end||16-OCT-2001|\23:Gallus gallus (chicken)
obj|String*|0
end|0
obj|String*|0
end|PRT
obj|String*|1| PTPN1
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obj|String*|0
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obj|String*|9|\46:swissprot: locus PTN1_CHICK, accession O13016;|class: standard.|\46:extra accessions:Q90704,created: Dec 15, 1998.|\31:sequence updated: Dec 15, 1998.|\33:annotation updated: Oct 16, 2001.|\57:xrefs: gi: 2058554, gi: 2058555, gi: 1209884, gi: 1209885|\62:xrefs (non-sequence databases): HSSPP18031, InterProIPR000387,|\60:InterProIPR000242, PfamPF00102, PRINTSPR00700, SMARTSM00194,|\46:PROSITEPS00383, PROSITEPS50056, PROSITEPS50055
end
obj|String*|35|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29|\44:VNTI URL:vnti:protein/cPTP1B_D1+%28O13016%29
end
obj|String*|0
end
obj|String*|0
end
end|342CB98
end
obj|IxMolX
obj|Molecule
obj|BioObject
obj|DBObj||\23:cPTPalpha_D1 (AAB04150)|||||302463254|0|\29:protein tyrosine phosphatase.
end|2|2|
obj|String*|0
end
obj|String*|1|\31:Method: conceptual translation.
end
obj|String*|5|\34:REFERENCE   1  (residues 1 to 807)|\21:  AUTHORS   Fang,K.S.|\78:  TITLE     Structural and functional characterization of two chicken tyrosine|\24:            phosphatases|\25:  JOURNAL   Thesis (1993)
end
obj|Object*|0
end
obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp
end
obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/
end
end|1|0|280
obj|Object*|3
obj|Feature
obj|DBObj||Source_1|||||0|0|
end|269|269|||0|1|280|1|1|1|1|1..807
obj|String*|5|\25:/organism="Gallus gallus"|\25:/sub_species="domesticus"|\21:/db_xref="taxon:9031"|/tissue_type="brain"|/dev_stage="E10"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||Protein_1|||||0|0|
end|270|270|||0|1|280|1|1|1|1|1..807
obj|String*|1|\39:/product="protein tyrosine phosphatase"
end|0||
obj|Object*|0
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obj|Feature
obj|DBObj||Chain_1|||||0|0|
end|203|203|||0|1|280|1|1|1|1|21..807
obj|String*|1|\39:/product="protein tyrosine phosphatase"
end|0||
obj|Object*|0
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end|\280:dkleeeinrrigddnklfreefnalpacpiqatceaaskeenkeknryvnilpydhsrvhltpvegvpdshyintsfinsyqeknkfiaaqgpkeetvndfwrmiweqntativmvtnlkerkeckcaqywpdqgcwtygnirvsvedvtvlvdytvrkfciqqvgdvtnkkpqrlvtqfhftswpdfgvpftpigmlkflkkvktcnpqyagaivvhcsagvgrtgtfividamldmmhaerkvdvygfvsriraqrcqmvqtdmqyvfiyqallehyl|GenPept|
obj|String*|1|AAB04150
end||23-JUL-1996|\23:Gallus gallus (chicken)
obj|String*|0
end|0
obj|String*|0
end|PRT
obj|String*|0
end
obj|String*|1|Gallus gallus
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obj|String*|0
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obj|String*|0
end
obj|String*|13|Eukaryota|Metazoa|Chordata|Craniata|Vertebrata|Euteleostomi|Archosauria|Aves|Neognathae|Galliformes|Phasianidae|Phasianinae|Gallus
end
obj|Object*|0
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obj|String*|0
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obj|String*|0
end
obj|String*|1|\32:locus CHKPTPA accession L22437.1
end
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end
obj|String*|0
end
obj|String*|0
end
end|20FAF40
end
obj|IxMolX
obj|Molecule
obj|BioObject
obj|DBObj||\23:cPTPalpha_D2 (AAB04150)|||||302464946|0|\29:protein tyrosine phosphatase.
end|2|2|
obj|String*|0
end
obj|String*|1|\31:Method: conceptual translation.
end
obj|String*|5|\34:REFERENCE   1  (residues 1 to 807)|\21:  AUTHORS   Fang,K.S.|\78:  TITLE     Structural and functional characterization of two chicken tyrosine|\24:            phosphatases|\25:  JOURNAL   Thesis (1993)
end
obj|Object*|0
end
obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp
end
obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/
end
end|1|0|281
obj|Object*|3
obj|Feature
obj|DBObj||Source_1|||||0|0|
end|269|269|||0|1|281|1|1|1|1|1..807
obj|String*|5|\25:/organism="Gallus gallus"|\25:/sub_species="domesticus"|\21:/db_xref="taxon:9031"|/tissue_type="brain"|/dev_stage="E10"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||Protein_1|||||0|0|
end|270|270|||0|1|281|1|1|1|1|1..807
obj|String*|1|\39:/product="protein tyrosine phosphatase"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||Chain_1|||||0|0|
end|203|203|||0|1|281|1|1|1|1|21..807
obj|String*|1|\39:/product="protein tyrosine phosphatase"
end|0||
obj|Object*|0
end
end
end|\281:tsleihlqkiynkvpgtssngleeefkkltsikiqndkmrtgnlpanmkknrvlqiipyefnrviipvkrgeentdyvnasfidgyrrrtptcqprpvqhtiedfwrmiwewkscsivmlteleergqekcaqywpsdgsvsygdinvelkkeeecesytvrdllvtntrenksrqirqfhfhgwpevgipsdgkgminiiaavqkqqqqsgnhpmhchcsagagrtgtfcalstvlervkaegildvfqtvkslrlqrphmvqtleqyefcykvvqeyid|GenPept|
obj|String*|1|AAB04150
end||23-JUL-1996|\23:Gallus gallus (chicken)
obj|String*|0
end|0
obj|String*|0
end|PRT
obj|String*|0
end
obj|String*|1|Gallus gallus
end
obj|String*|0
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obj|String*|0
end
obj|String*|13|Eukaryota|Metazoa|Chordata|Craniata|Vertebrata|Euteleostomi|Archosauria|Aves|Neognathae|Galliformes|Phasianidae|Phasianinae|Gallus
end
obj|Object*|0
end
obj|String*|0
end
obj|String*|0
end
obj|String*|1|\32:locus CHKPTPA accession L22437.1
end
obj|String*|13|\49:VNTI URL:vnti:protein/cPTPalpha_D2+%28AAB04150%29|\49:VNTI URL:vnti:protein/cPTPalpha_D2+%28AAB04150%29|\49:VNTI URL:vnti:protein/cPTPalpha_D2+%28AAB04150%29|\49:VNTI URL:vnti:protein/cPTPalpha_D2+%28AAB04150%29|\49:VNTI URL:vnti:protein/cPTPalpha_D2+%28AAB04150%29|\49:VNTI URL:vnti:protein/cPTPalpha_D2+%28AAB04150%29|\49:VNTI URL:vnti:protein/cPTPalpha_D2+%28AAB04150%29|\49:VNTI URL:vnti:protein/cPTPalpha_D2+%28AAB04150%29|\49:VNTI URL:vnti:protein/cPTPalpha_D2+%28AAB04150%29|\49:VNTI URL:vnti:protein/cPTPalpha_D2+%28AAB04150%29|\49:VNTI URL:vnti:protein/cPTPalpha_D2+%28AAB04150%29|\49:VNTI URL:vnti:protein/cPTPalpha_D2+%28AAB04150%29|\49:VNTI URL:vnti:protein/cPTPalpha_D2+%28AAB04150%29
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obj|String*|0
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obj|String*|0
end
end|24BC628
end
obj|IxMolX
obj|Molecule
obj|BioObject
obj|DBObj||\21:cPTPgamma_D1 (Q98936)|||||302464404|0|\59:Protein-tyrosine phosphatase gamma precursor (R-PTP-gamma).
end|2|2|
obj|String*|5|Glycoprotein|Transmembrane|Hydrolase|Repeat|Signal
end
obj|String*|14|\67:-------------------------------------------------------------------|\60:This SWISS-PROT entry is copyright. It is produced through a|\63:collaboration between the Swiss Institute of Bioinformatics and|\60:the EMBL outstation - the European Bioinformatics Institute.|\63:The original entry is available from http://www.expasy.ch/sprot|\30:and http://www.ebi.ac.uk/sprot|\67:------------------------------------------------------------------.|\65:[CATALYTIC ACTIVITY] Protein tyrosine phosphate + H(2)O = protein|\21:tyrosine + phosphate.|\58:[SUBCELLULAR LOCATION] Type I membrane protein (Probable).|\54:[SIMILARITY] IN THE N-TERMINAL SECTION; BELONGS TO THE|\42:EUKARYOTIC-TYPE CARBONIC ANHYDRASE FAMILY.|\61:[SIMILARITY] CONTAINS 2 PROTEIN-TYROSINE PHOSPHATASE DOMAINS.|\57:[SIMILARITY] CONTAINS 1 FIBRONECTIN TYPE III-LIKE DOMAIN.
end
obj|String*|7|\35:REFERENCE   1  (residues 1 to 1422)|\78:  AUTHORS   Qinghua,X., Xiaojun,G., Cong,S., Zong,S.M., Jong,Y.J., Chan,J. and|\22:            Wang,L.-H.|\29:  TITLE     Direct Submission|\33:  JOURNAL   Submitted (~OCT-1995)|\30:  REMARK    SEQUENCE FROM N.A.|\36:            TISSUE=Brain, and Kidney
end
obj|Object*|0
end
obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp
end
obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/
end
end|1|0|291
obj|Object*|6
obj|Feature
obj|DBObj||Source_1|||||0|0|
end|269|269|||0|1|291|1|1|1|1|1..1422
obj|String*|2|\25:/organism="Gallus gallus"|\21:/db_xref="taxon:9031"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||PTPRG|||||0|0|
end|270|270|||0|1|291|1|1|1|1|1..1422
obj|String*|3|/gene="PTPRG"|\55:/product="Protein-tyrosine phosphatase gamma precursor"|\21:/EC_number="3.1.3.48"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||PTPRG|||||0|0|\35:PROTEIN-TYROSINE PHOSPHATASE GAMMA.
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obj|String*|2|/gene="PTPRG"|\27:/region_name="Mature chain"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||PTPRG|||||0|0|\24:CYTOPLASMIC (POTENTIAL).
end|1004|1004|||0|1|291|1|1|1|1|769..1422
obj|String*|2|/gene="PTPRG"|\21:/region_name="Domain"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||PTPRG|||||0|0|\31:PROTEIN-TYROSINE PHOSPHATASE 1.
end|1000|1000|||0|39|291|1|1|1|1|846..1102
obj|String*|2|/gene="PTPRG"|\21:/region_name="Domain"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||PTPRG|||||0|0|BY SIMILARITY.
end|220|220|||0|230|230|1|1|1|1|1037
obj|String*|2|/gene="PTPRG"|/site_type="active"
end|0||
obj|Object*|0
end
end
end|\291:kqfvkhiselysnnqhgfsedfeevqrctadmnitaehsnhpdnkhknryinilaydhsrvklrplpgkdskhsdyinanyvsgynkakayiatqgplkstfedfwrmiwaqhtgiivmitnlvekgrrkcdqywptenseeygniivtlkstnihacytvrplhgqehkdekgserkpkgrqnertviqyhytqwpdmgvpeyalpvltfvrrssaartphmgpvvvhcsagvgrtgtyividsmlqqikdkstvnvlgflkhirtqrnylvqteeqyifihdalleail|GenPept|
obj|String*|1|Q98936
end||15-JUN-2002|\23:Gallus gallus (chicken)
obj|String*|0
end|0
obj|String*|0
end|PRT
obj|String*|1| PTPRG
end
obj|String*|1|Gallus gallus
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obj|String*|0
end
obj|String*|0
end
obj|String*|13|Eukaryota|Metazoa|Chordata|Craniata|Vertebrata|Euteleostomi|Archosauria|Aves|Neognathae|Galliformes|Phasianidae|Phasianinae|Gallus
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obj|String*|11|\46:swissprot: locus PTPG_CHICK, accession Q98936;|class: standard.|\22:created: Jul 15, 1999.|\31:sequence updated: Jul 15, 1999.|\33:annotation updated: Jun 15, 2002.|\31:xrefs: gi: 1617477, gi: 1617478|\62:xrefs (non-sequence databases): HSSPP18052, InterProIPR001148,|\56:InterProIPR003961, InterProIPR000387, InterProIPR000242,|\53:PfamPF00041, PfamPF00102, PfamPF00194, PRINTSPR00700,|\59:ProDomPD000865, SMARTSM00060, SMARTSM00194, PROSITEPS00383,|\30:PROSITEPS50056, PROSITEPS50055
end
obj|String*|49|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D1+%28Q98936%29
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end|21ED558
end
obj|IxMolX
obj|Molecule
obj|BioObject
obj|DBObj||\21:cPTPgamma_D2 (Q98936)|||||302464892|0|\59:Protein-tyrosine phosphatase gamma precursor (R-PTP-gamma).
end|2|2|
obj|String*|5|Glycoprotein|Transmembrane|Hydrolase|Repeat|Signal
end
obj|String*|14|\67:-------------------------------------------------------------------|\60:This SWISS-PROT entry is copyright. It is produced through a|\63:collaboration between the Swiss Institute of Bioinformatics and|\60:the EMBL outstation - the European Bioinformatics Institute.|\63:The original entry is available from http://www.expasy.ch/sprot|\30:and http://www.ebi.ac.uk/sprot|\67:------------------------------------------------------------------.|\65:[CATALYTIC ACTIVITY] Protein tyrosine phosphate + H(2)O = protein|\21:tyrosine + phosphate.|\58:[SUBCELLULAR LOCATION] Type I membrane protein (Probable).|\54:[SIMILARITY] IN THE N-TERMINAL SECTION; BELONGS TO THE|\42:EUKARYOTIC-TYPE CARBONIC ANHYDRASE FAMILY.|\61:[SIMILARITY] CONTAINS 2 PROTEIN-TYROSINE PHOSPHATASE DOMAINS.|\57:[SIMILARITY] CONTAINS 1 FIBRONECTIN TYPE III-LIKE DOMAIN.
end
obj|String*|7|\35:REFERENCE   1  (residues 1 to 1422)|\78:  AUTHORS   Qinghua,X., Xiaojun,G., Cong,S., Zong,S.M., Jong,Y.J., Chan,J. and|\22:            Wang,L.-H.|\29:  TITLE     Direct Submission|\33:  JOURNAL   Submitted (~OCT-1995)|\30:  REMARK    SEQUENCE FROM N.A.|\36:            TISSUE=Brain, and Kidney
end
obj|Object*|0
end
obj|CreatorData|||||\28:jannik@noergaardandersen.com|||JNA||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp
end
obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/
end
end|1|0|283
obj|Object*|6
obj|Feature
obj|DBObj||Source_1|||||0|0|
end|269|269|||0|1|283|1|1|1|1|1..1422
obj|String*|2|\25:/organism="Gallus gallus"|\21:/db_xref="taxon:9031"
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obj|Object*|0
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obj|Feature
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obj|Feature
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obj|Feature
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end|0||
obj|Object*|0
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obj|Feature
obj|DBObj||PTPRG|||||0|0|\31:PROTEIN-TYROSINE PHOSPHATASE 2.
end|1000|1000|||0|1|283|1|1|1|1|1103..1422
obj|String*|2|/gene="PTPRG"|\21:/region_name="Domain"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||PTPRG|||||0|0|\22:ANCESTRAL ACTIVE SITE.
end|265|265|||0|222|222|1|1|1|1|1328
obj|String*|2|/gene="PTPRG"|\25:/site_type="unclassified"
end|0||
obj|Object*|0
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obj|String*|1|Q98936
end||15-JUN-2002|\23:Gallus gallus (chicken)
obj|String*|0
end|0
obj|String*|0
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obj|String*|11|\46:swissprot: locus PTPG_CHICK, accession Q98936;|class: standard.|\22:created: Jul 15, 1999.|\31:sequence updated: Jul 15, 1999.|\33:annotation updated: Jun 15, 2002.|\31:xrefs: gi: 1617477, gi: 1617478|\62:xrefs (non-sequence databases): HSSPP18052, InterProIPR001148,|\56:InterProIPR003961, InterProIPR000387, InterProIPR000242,|\53:PfamPF00041, PfamPF00102, PfamPF00194, PRINTSPR00700,|\59:ProDomPD000865, SMARTSM00060, SMARTSM00194, PROSITEPS00383,|\30:PROSITEPS50056, PROSITEPS50055
end
obj|String*|7|\47:VNTI URL:vnti:protein/cPTPgamma_D2+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D2+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D2+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D2+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D2+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D2+%28Q98936%29|\47:VNTI URL:vnti:protein/cPTPgamma_D2+%28Q98936%29
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end|28A56A8
end
obj|IxMolX
obj|Molecule
obj|BioObject
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end|2|2|
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end
obj|String*|0
end
obj|String*|6|\35:REFERENCE   1  (residues 1 to 1499)|\23:  AUTHORS   Stoker,A.W.|\76:  TITLE     Isoforms of a novel cell adhesion molecule-like protein tyrosine|\60:            phosphatase are implicated in neural development|\45:  JOURNAL   Mech. Dev. 46 (3), 201-217 (1994)|  MEDLINE   95001563
end
obj|Object*|0
end
obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp
end
obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/
end
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obj|Feature
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obj|Feature
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end
obj|Feature
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end|1000|1000|||0|1|275|1|1|1|1|1..275
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end|0||
obj|Object*|0
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obj|Feature
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obj|Feature
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end|1007|1007|||0|220|220|1|1|1|1|220..220
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obj|String*|1|I50212
end||17-MAY-2003|\24:Gallus gallus (chicken).
obj|String*|0
end|0
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obj|String*|13|pir: locus I50212;|\61:summary: #length 1499 #molecular-weight 168570 #checksum 8393|;|\25:genetic: #gene CRYPalpha1|;|\64:superfamily: leukocyte antigen-related protein; fibronectin type|\62:III repeat homology; immunoglobulin homology; leukocyte common|\63:antigen cytosolic domain homology; protein-tyrosine-phosphatase|homology|;|\66:PIR dates: 13-Sep-1996 #sequence_revision 13-Sep-1996 #text_change|21-Jan-2000|.
end
obj|String*|54|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D1+%28I50212%29
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end|F89CF0
end
obj|IxMolX
obj|Molecule
obj|BioObject
obj|DBObj||\21:cPTPsigma_D2 (I50212)|||||302465404|0|\53:protein-tyrosine-phosphatase (EC 3.1.3.48) - chicken.
end|2|2|
obj|String*|3|phosphoprotein|\30:phosphoric monoester hydrolase|\29:tyrosine-specific phosphatase
end
obj|String*|0
end
obj|String*|6|\35:REFERENCE   1  (residues 1 to 1499)|\23:  AUTHORS   Stoker,A.W.|\76:  TITLE     Isoforms of a novel cell adhesion molecule-like protein tyrosine|\60:            phosphatase are implicated in neural development|\45:  JOURNAL   Mech. Dev. 46 (3), 201-217 (1994)|  MEDLINE   95001563
end
obj|Object*|0
end
obj|CreatorData|||||\28:jannik@noergaardandersen.com|||JNA||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp
end
obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/
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end|1|0|282
obj|Object*|6
obj|Feature
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end|269|269|||0|1|282|1|1|1|1|1..1499
obj|String*|2|\25:/organism="Gallus gallus"|\21:/db_xref="taxon:9031"
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obj|Object*|0
end
end
obj|Feature
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end|270|270|||0|1|282|1|1|1|1|1..1499
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end|0||
obj|Object*|0
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end
obj|Feature
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end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||PTP2|||||0|0|\49:protein-tyrosine-phosphatase homology #label PTP2
end|1000|1000|||0|47|269|1|1|1|1|1257..1479
obj|String*|1|\21:/region_name="domain"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||Active_Site_2|||||0|0|\34:Cys (phosphocysteine intermediate)
end|220|220|||0|222|222|1|1|1|1|1432
obj|String*|1|/site_type="active"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||Binding_2|||||0|0|\25:substrate phosphate (Arg)
end|1007|1007|||0|228|228|1|1|1|1|1438
obj|String*|1|/site_type="binding"
end|0||
obj|Object*|0
end
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end|\282:rnlytyiqklaqievgehvtgmelefkrlanskahtsrfisanlpcnkfknrlvnimpyettrvclqpirgvegsdyinasfidgyrqqkayiatqgplaettedfwrmlwennstivvmltklremgrekchqywpaersaryqyfvvdpmaeynmpqyilrefkvtdardgqsrtvrqfqftdwpeqgvpksgegfidfigqvhktkeqfgqdgpisvhcsagvgrtgvfitlsivlermryegvvdifqtvkmlrtqpamvqtedeyqfcyqaaleylg|GenPept|
obj|String*|1|I50212
end||21-JAN-2000|\23:Gallus gallus (chicken)
obj|String*|0
end|0
obj|String*|0
end|PRT
obj|String*|0
end
obj|String*|1|Gallus gallus
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obj|String*|0
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obj|String*|0
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obj|String*|13|Eukaryota|Metazoa|Chordata|Craniata|Vertebrata|Euteleostomi|Archosauria|Aves|Neognathae|Galliformes|Phasianidae|Phasianinae|Gallus
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obj|String*|13|pir: locus I50212;|\61:summary: #length 1499 #molecular-weight 168570 #checksum 8393|;|\25:genetic: #gene CRYPalpha1|;|\64:superfamily: leukocyte antigen-related protein; fibronectin type|\62:III repeat homology; immunoglobulin homology; leukocyte common|\63:antigen cytosolic domain homology; protein-tyrosine-phosphatase|homology|;|\66:PIR dates: 13-Sep-1996 #sequence_revision 13-Sep-1996 #text_change|21-Jan-2000|.
end
obj|String*|9|\47:VNTI URL:vnti:protein/cPTPsigma_D2+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D2+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D2+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D2+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D2+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D2+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D2+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D2+%28I50212%29|\47:VNTI URL:vnti:protein/cPTPsigma_D2+%28I50212%29
end
obj|String*|0
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obj|String*|0
end
end|28C7478
end
obj|IxMolX
obj|Molecule
obj|BioObject
obj|DBObj||\22:cPTPzeta_D1 (AAA49015)|||||302464518|0|\27:phosphotyrosyl phosphatase.
end|2|2|
obj|String*|0
end
obj|String*|1|\31:Method: conceptual translation.
end
obj|String*|8|\34:REFERENCE   1  (residues 1 to 832)|\72:  AUTHORS   Rowley,R.B., Lee,J.M., Corbeil,H.B., Charbonneau,R., Jue,K.,|\41:            Dankort,D.L. and Branton,P.E.|\78:  TITLE     Isolation of chicken phosphotyrosyl phosphatase cDNA sequences and|\75:            identification of a brain-specific species related to human PTP|            zeta|\56:  JOURNAL   Cell. Mol. Biol. Res. 39 (3), 209-219 (1993)|  MEDLINE   94122757
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obj|Object*|0
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obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp
end
obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/
end
end|1|0|286
obj|Object*|2
obj|Feature
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obj|String*|6|\25:/organism="Gallus gallus"|\25:/sub_species="domesticus"|\21:/db_xref="taxon:9031"|\21:/tissue_type="embryo"|/dev_stage="10 day"|\30:/tissue_lib="Clontech CL1001b"
end|0||
obj|Object*|0
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obj|Feature
obj|DBObj||Protein_1|||||0|0|
end|270|270|||0|1|286|1|1|1|1|1..832
obj|String*|1|\37:/product="phosphotyrosyl phosphatase"
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obj|Object*|0
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end|\286:khfpkhvadlhasngfseefeeiqsctvdlgitsdssnhpdnknknryinivaydhtrvklaqlaekdgkltdyinanyvdgynkpkayiaaqgplkstaedfwrmiwehnvevivmitnllekgrrkcdqywpaegseeygnflvtqksvhvlayytvrnftlrntkikkgsqkgrssgrvvtqyhytqwpdmgvpeytlpvltfvrkashakrhavgpivvhcsagvgrtgtyvvldsmlqqiqhegtvnifgflkhirtqrnylvqteeqyifihdalveail|GenPept|
obj|String*|1|AAA49015
end||14-JAN-1994|\23:Gallus gallus (chicken)
obj|String*|0
end|0
obj|String*|0
end|PRT
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end
obj|String*|1|Gallus gallus
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obj|String*|0
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obj|String*|0
end
obj|String*|1|\35:locus CHKPHOPHOS accession L27625.1
end
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obj|IxMolX
obj|Molecule
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end
obj|String*|8|\34:REFERENCE   1  (residues 1 to 832)|\72:  AUTHORS   Rowley,R.B., Lee,J.M., Corbeil,H.B., Charbonneau,R., Jue,K.,|\41:            Dankort,D.L. and Branton,P.E.|\78:  TITLE     Isolation of chicken phosphotyrosyl phosphatase cDNA sequences and|\75:            identification of a brain-specific species related to human PTP|            zeta|\56:  JOURNAL   Cell. Mol. Biol. Res. 39 (3), 209-219 (1993)|  MEDLINE   94122757
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obj|CreatorData|||||\28:jannik@noergaardandersen.com|||JNA||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp
end
obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/
end
end|1|0|282
obj|Object*|2
obj|Feature
obj|DBObj||Source_1|||||0|0|
end|269|269|||0|1|282|1|1|1|1|1..832
obj|String*|6|\25:/organism="Gallus gallus"|\25:/sub_species="domesticus"|\21:/db_xref="taxon:9031"|\21:/tissue_type="embryo"|/dev_stage="10 day"|\30:/tissue_lib="Clontech CL1001b"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||Protein_1|||||0|0|
end|270|270|||0|1|282|1|1|1|1|1..832
obj|String*|1|\37:/product="phosphotyrosyl phosphatase"
end|0||
obj|Object*|0
end
end
end|\282:thihayvnallipgptgktrlekqfkllsqsntqqcdystalkqcnreknrtssiipversrvgisslsgegtdyinasyimgyyqsnefiitqhpllhtikdfwrmiwdhnaqlivmlpdsqnmaedefvywpnkdepincetfkvtmiaeehkclskeekliiqdfileatqddyvlevrhfqcpkwpnpdspisktfelisiikeetsnrdgpmivhdehggvtagtfcalttlmhqlenensvdvyqvakminlmrpgvftdieqyqflykailslvs|GenPept|
obj|String*|1|AAA49015
end||14-JAN-1994|\23:Gallus gallus (chicken)
obj|String*|0
end|0
obj|String*|0
end|PRT
obj|String*|0
end
obj|String*|1|Gallus gallus
end
obj|String*|0
end
obj|String*|0
end
obj|String*|13|Eukaryota|Metazoa|Chordata|Craniata|Vertebrata|Euteleostomi|Archosauria|Aves|Neognathae|Galliformes|Phasianidae|Phasianinae|Gallus
end
obj|Object*|0
end
obj|String*|0
end
obj|String*|0
end
obj|String*|1|\35:locus CHKPHOPHOS accession L27625.1
end
obj|String*|7|\48:VNTI URL:vnti:protein/cPTPzeta_D2+%28AAA49015%29|\48:VNTI URL:vnti:protein/cPTPzeta_D2+%28AAA49015%29|\48:VNTI URL:vnti:protein/cPTPzeta_D2+%28AAA49015%29|\48:VNTI URL:vnti:protein/cPTPzeta_D2+%28AAA49015%29|\48:VNTI URL:vnti:protein/cPTPzeta_D2+%28AAA49015%29|\48:VNTI URL:vnti:protein/cPTPzeta_D2+%28AAA49015%29|\48:VNTI URL:vnti:protein/cPTPzeta_D2+%28AAA49015%29
end
obj|String*|0
end
obj|String*|0
end
end|2991C90
end
obj|IxMolX
obj|Molecule
obj|BioObject
obj|DBObj||cSHP2_D1 (JC5167)|||||302464602|0|\74:protein-tyrosine-phosphatase (EC 3.1.3.48), nonreceptor type 11 - chicken.
end|2|2|
obj|String*|3|phosphoprotein|\30:phosphoric monoester hydrolase|\29:tyrosine-specific phosphatase
end
obj|String*|2|\65:This enzyme plays positive roles in mitogenic signaling and early|development.
end
obj|String*|7|\34:REFERENCE   1  (residues 1 to 593)|\66:  AUTHORS   Park,C.Y., LaMontagne,K.R., Tonks,N.K. and Hayman,M.J.|\78:  TITLE     Cloning and expression of the chicken protein tyrosine phosphatase|            SH-PTP2|\40:  JOURNAL   Gene 177 (1-2), 93-97 (1996)|  MEDLINE   97080506|\24:  REMARK    erythroblast
end
obj|Object*|0
end
obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp
end
obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/
end
end|1|0|300
obj|Object*|5
obj|Feature
obj|DBObj||Source_1|||||0|0|
end|269|269|||0|1|300|1|1|1|1|1..593
obj|String*|2|\25:/organism="Gallus gallus"|\21:/db_xref="taxon:9031"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||Protein_1|||||0|0|\55:phosphotyrosine phosphatase; PTP1D; PTP2c; SH-PTP2; SyP
end|270|270|||0|1|300|1|1|1|1|1..593
obj|String*|3|\56:/product="protein-tyrosine-phosphatase, nonreceptor type|11"|\21:/EC_number="3.1.3.48"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||PTP|||||0|0|\48:protein-tyrosine-phosphatase homology #label PTP
end|1000|1000|||0|50|287|1|1|1|1|273..510
obj|String*|1|\21:/region_name="domain"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||Active_Site_1|||||0|0|\34:Cys (phosphocysteine intermediate)
end|220|220|||0|236|236|1|1|1|1|459
obj|String*|1|/site_type="active"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||Binding_1|||||0|0|\25:substrate phosphate (Arg)
end|1007|1007|||0|242|242|1|1|1|1|465
obj|String*|1|/site_type="binding"
end|0||
obj|Object*|0
end
end
end|\300:aeiesrvrelsklaettdkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpnepvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttkevergkskcvkywpdeyslkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesisdagpvvvhcsagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyie|GenPept|
obj|String*|1|JC5167
end||16-JUL-1999|\23:Gallus gallus (chicken)
obj|String*|0
end|0
obj|String*|0
end|PRT
obj|String*|0
end
obj|String*|1|Gallus gallus
end
obj|String*|0
end
obj|String*|0
end
obj|String*|13|Eukaryota|Metazoa|Chordata|Craniata|Vertebrata|Euteleostomi|Archosauria|Aves|Neognathae|Galliformes|Phasianidae|Phasianinae|Gallus
end
obj|Object*|0
end
obj|String*|0
end
obj|String*|0
end
obj|String*|9|pir: locus JC5167;|\59:summary: #length 593 #molecular-weight 67982 #checksum 3712|;|\62:superfamily: protein-tyrosine-phosphatase, nonreceptor type 6;|\51:protein-tyrosine-phosphatase homology; SH2 homology|;|\66:PIR dates: 21-Feb-1997 #sequence_revision 27-Feb-1997 #text_change|16-Jul-1999|.
end
obj|String*|51|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29|\43:VNTI URL:vnti:protein/cSHP2_D1+%28JC5167%29
end
obj|String*|0
end
obj|String*|0
end
end|2052590
end
obj|IxMolX
obj|Molecule
obj|BioObject
obj|DBObj||\23:cypcaCD45_D1 (BAA92179)|||||302454614|0|\23:CD45 [Cyprinus carpio].
end|2|2|
obj|String*|0
end
obj|String*|0
end
obj|String*|15|REFERENCE   1|\54:  AUTHORS   Fujiki,K., Shin,D.H., Nakao,M. and Yano,T.|\78:  TITLE     Molecular cloning of carp (Cyprinus carpio) leucocyte cell-derived|\77:            chemotaxin 2, glia maturation factor beta, CD45 and lysozyme C by|\56:            use of suppression subtractive hybridisation|\58:  JOURNAL   Fish Shellfish Immunol. 10 (7), 643-650 (2000)|  MEDLINE   20531692|\35:REFERENCE   2  (residues 1 to 1216)|\52:  AUTHORS   Fujiki,K., Nakao,M., Shin,D. and Yano,T.|\29:  TITLE     Direct Submission|\71:  JOURNAL   Submitted (24-AUG-1999) Kazuhiro Fujiki, Kyushu University,|\79:            Laboratory of Marine Biochemistry, Faculty of Agriculture; Hakozaki|\64:            6-10-1, Higashi-ku, Fukuoka, Fukuoka 812-8581, Japan|\67:            (E-mail:fujikik@agr.kyushu-u.ac.jp, Tel:81-92-642-2896,|\31:            Fax:81-92-642-2894)
end
obj|Object*|0
end
obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp
end
obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/
end
end|1|0|276
obj|Object*|2
obj|Feature
obj|DBObj||Source_1|||||0|0|
end|269|269|||0|1|276|1|1|1|1|1..1216
obj|String*|3|\27:/organism="Cyprinus carpio"|\21:/db_xref="taxon:7962"|\23:/cell_type="leukocytes"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||Protein_1|||||0|0|
end|270|270|||0|1|276|1|1|1|1|1..1216
obj|String*|1|/product="CD45"
end|0||
obj|Object*|0
end
end
end|\276:gglveayknkiadegrlfmdefqsiprifsnytikeakksenqyknryvdilpydynrvtlstggednyinasfiegyrepkkyiaaqgpkdetvvdfwrmvweqkssiivmvtrceegnktkcaqywpsldreaeifeefvvkirseehcpdyvirhlilnnkrekgserevthiqfiswpdhgvpgdpslllklrrrvnsfknffsgpvvvhcsagvgrtgtymsidamiesleaegrvdiygfvaklrrqrclmvqveaqyilihtalieynq|GenPept|
obj|String*|1|BAA92179
end||17-APR-2002|\29:Cyprinus carpio (common carp)
obj|String*|0
end|0
obj|String*|0
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obj|String*|0
end
obj|String*|1|Cyprinus carpio
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obj|String*|0
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obj|String*|0
end
obj|String*|13|Eukaryota|Metazoa|Chordata|Craniata|Vertebrata|Euteleostomi|Actinopterygii|Neopterygii|Teleostei|Ostariophysi|Cypriniformes|Cyprinidae|Cyprinus
end
obj|Object*|0
end
obj|String*|0
end
obj|String*|0
end
obj|String*|1|accession AB031424.1
end
obj|String*|48|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D1+%28BAA92179%29
end
obj|String*|0
end
obj|String*|0
end
end|270C158
end
obj|IxMolX
obj|Molecule
obj|BioObject
obj|DBObj||\23:cypcaCD45_D2 (BAA92179)|||||302454709|0|\23:CD45 [Cyprinus carpio].
end|2|2|
obj|String*|0
end
obj|String*|0
end
obj|String*|15|REFERENCE   1|\54:  AUTHORS   Fujiki,K., Shin,D.H., Nakao,M. and Yano,T.|\78:  TITLE     Molecular cloning of carp (Cyprinus carpio) leucocyte cell-derived|\77:            chemotaxin 2, glia maturation factor beta, CD45 and lysozyme C by|\56:            use of suppression subtractive hybridisation|\58:  JOURNAL   Fish Shellfish Immunol. 10 (7), 643-650 (2000)|  MEDLINE   20531692|\35:REFERENCE   2  (residues 1 to 1216)|\52:  AUTHORS   Fujiki,K., Nakao,M., Shin,D. and Yano,T.|\29:  TITLE     Direct Submission|\71:  JOURNAL   Submitted (24-AUG-1999) Kazuhiro Fujiki, Kyushu University,|\79:            Laboratory of Marine Biochemistry, Faculty of Agriculture; Hakozaki|\64:            6-10-1, Higashi-ku, Fukuoka, Fukuoka 812-8581, Japan|\67:            (E-mail:fujikik@agr.kyushu-u.ac.jp, Tel:81-92-642-2896,|\31:            Fax:81-92-642-2894)
end
obj|Object*|0
end
obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp
end
obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/
end
end|1|0|302
obj|Object*|2
obj|Feature
obj|DBObj||Source_1|||||0|0|
end|269|269|||0|1|302|1|1|1|1|1..1216
obj|String*|3|\27:/organism="Cyprinus carpio"|\21:/db_xref="taxon:7962"|\23:/cell_type="leukocytes"
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obj|Feature
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end|270|270|||0|1|302|1|1|1|1|1..1216
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obj|Object*|0
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end|\302:sefhsvlntlrqkngsdpsllekefqklpkfkkwrtmntgssednkkknrdsavipydfnrvifrldiegnqtsdpedeeeyssdeeeesnqyinasfidgywcnksliaaqgplqstaeefllmlyqqqtktlvmltdcqedgkdycfqywgdekktygdmeievkktetfptyvrrhleiqslkkkevlkvdqyqflkwrgrelpenaqelvemasiirenghydnsktnrnvpivvhcnngssrtgifcalwnlldsayteklvdvlqevknlrklrqgmvetieqyqflytalegafp|GenPept|
obj|String*|1|BAA92179
end||17-APR-2002|\29:Cyprinus carpio (common carp)
obj|String*|0
end|0
obj|String*|0
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obj|String*|0
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end
obj|Object*|0
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obj|String*|0
end
obj|String*|1|accession AB031424.1
end
obj|String*|15|\49:VNTI URL:vnti:protein/cypcaCD45_D2+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D2+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D2+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D2+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D2+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D2+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D2+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D2+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D2+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D2+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D2+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D2+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D2+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D2+%28BAA92179%29|\49:VNTI URL:vnti:protein/cypcaCD45_D2+%28BAA92179%29
end
obj|String*|0
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obj|String*|0
end
end|F9FA00
end
obj|IxMolX
obj|Molecule
obj|BioObject
obj|DBObj||fuCD45_D1 (CAB96211)|||||302488418|0|\25:CD45 [Takifugu rubripes].
end|2|2|
obj|String*|0
end
obj|String*|0
end
obj|String*|12|REFERENCE   1|\58:  AUTHORS   Diaz del Pozo,E.M., Beverley,P.C. and Timon,M.|\74:  TITLE     Genomic structure and sequence of the leukocyte common antigen|\76:            (CD45) from the pufferfish Fugu rubripes and comparison with its|\31:            mammalian homologue|\23:  JOURNAL   Unpublished|\35:REFERENCE   2  (residues 1 to 1246)|\30:  AUTHORS   Diaz del Pozo,E.M.|\29:  TITLE     Direct Submission|\78:  JOURNAL   Submitted (25-JUN-1999) Diaz del Pozo E.M., CD45 Group, The Edward|\72:            Jenner Institute for Vaccine Research, High Street, Compton,|\56:            Newbury, Berkshire, RG20 7NN, UNITED KINGDOM
end
obj|Object*|0
end
obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp
end
obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/
end
end|1|0|279
obj|Object*|3
obj|Feature
obj|DBObj||Source_1|||||0|0|
end|269|269|||0|1|279|1|1|1|1|1..1246
obj|String*|4|\29:/organism="Takifugu rubripes"|\22:/db_xref="taxon:31033"|/clone="ptp-16"|\21:/tissue_type="spleen"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||Protein_1|||||0|0|
end|270|270|||0|1|279|1|1|1|1|1..1246
obj|String*|3|/product="CD45"|\21:/EC_number="3.1.3.48"|\40:/function="protein tyrosine phosphatase"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||Chain_1|||||0|0|
end|203|203|||0|1|279|1|1|1|1|20..1246
obj|String*|2|/product="CD45"|\21:/EC_number="3.1.3.48"
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end|\279:etlldaykrkiadegrlflaefqsiprifskytvkeakkshnvpknryvdilpydynrvqlttgngsagcdyinasfidgfkelkkyiaaqgpkeetvsnfwrmiweqqtsiivmvsrceegnrikcaqywpsedrdteifeefivkltsedhypdyiirhlsltnkkdkgserevthiqfmswpdhgvpeeaqlllklrrrvnsfknffsgpivvhcsagvgrtgtyigidammesleaegrvdiygyvvmlrrqrclmvqveaqyilihqallehtq|GenPept|
obj|String*|1|CAB96211
end||03-JUL-2000|Takifugu rubripes
obj|String*|0
end|0
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end|PRT
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end
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end
obj|String*|0
end
obj|String*|0
end
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end
obj|Object*|0
end
obj|String*|0
end
obj|String*|0
end
obj|String*|1|\42:embl locus FRU243429, accession AJ243429.1
end
obj|String*|48|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D1+%28CAB96211%29
end
obj|String*|0
end
obj|String*|0
end
end|278FC28
end
obj|IxMolX
obj|Molecule
obj|BioObject
obj|DBObj||fuCD45_D2 (CAB96211)|||||302488507|0|\25:CD45 [Takifugu rubripes].
end|2|2|
obj|String*|0
end
obj|String*|0
end
obj|String*|12|REFERENCE   1|\58:  AUTHORS   Diaz del Pozo,E.M., Beverley,P.C. and Timon,M.|\74:  TITLE     Genomic structure and sequence of the leukocyte common antigen|\76:            (CD45) from the pufferfish Fugu rubripes and comparison with its|\31:            mammalian homologue|\23:  JOURNAL   Unpublished|\35:REFERENCE   2  (residues 1 to 1246)|\30:  AUTHORS   Diaz del Pozo,E.M.|\29:  TITLE     Direct Submission|\78:  JOURNAL   Submitted (25-JUN-1999) Diaz del Pozo E.M., CD45 Group, The Edward|\72:            Jenner Institute for Vaccine Research, High Street, Compton,|\56:            Newbury, Berkshire, RG20 7NN, UNITED KINGDOM
end
obj|Object*|0
end
obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp
end
obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/
end
end|1|0|301
obj|Object*|3
obj|Feature
obj|DBObj||Source_1|||||0|0|
end|269|269|||0|1|301|1|1|1|1|1..1246
obj|String*|4|\29:/organism="Takifugu rubripes"|\22:/db_xref="taxon:31033"|/clone="ptp-16"|\21:/tissue_type="spleen"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||Protein_1|||||0|0|
end|270|270|||0|1|301|1|1|1|1|1..1246
obj|String*|3|/product="CD45"|\21:/EC_number="3.1.3.48"|\40:/function="protein tyrosine phosphatase"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||Chain_1|||||0|0|
end|203|203|||0|1|301|1|1|1|1|20..1246
obj|String*|2|/product="CD45"|\21:/EC_number="3.1.3.48"
end|0||
obj|Object*|0
end
end
end|\301:qelhstlntlkqrssdneptlledeferlpnfknwrtfntgvteenkkknrtssvipydynrvllkldeekshesdpdpdddydtssyddiedsakyinasllsgywgphtfisaqtplpdtvadfwsmilqkrvsivvmlsdcsqgdedcvywgedkktvedievetestdnspnfilrnmmihhlktdahqqvkhfqflkwgdkevpekpqdladlikeikhrcgytwprstpiivhcndgssrsgafcalwnlldnaekekmvdvfqvvktlrkerqgmcpsleqyqflydalevvyp|GenPept|
obj|String*|1|CAB96211
end||03-JUL-2000|Takifugu rubripes
obj|String*|0
end|0
obj|String*|0
end|PRT
obj|String*|0
end
obj|String*|1|Takifugu rubripes
end
obj|String*|0
end
obj|String*|0
end
obj|String*|18|Eukaryota|Metazoa|Chordata|Craniata|Vertebrata|Euteleostomi|Actinopterygii|Neopterygii|Teleostei|Euteleostei|Neoteleostei|Acanthomorpha|Acanthopterygii|Percomorpha|Tetraodontiformes|Tetradontoidea|Tetraodontidae|Takifugu
end
obj|Object*|0
end
obj|String*|0
end
obj|String*|0
end
obj|String*|1|\42:embl locus FRU243429, accession AJ243429.1
end
obj|String*|15|\46:VNTI URL:vnti:protein/fuCD45_D2+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D2+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D2+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D2+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D2+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D2+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D2+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D2+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D2+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D2+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D2+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D2+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D2+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D2+%28CAB96211%29|\46:VNTI URL:vnti:protein/fuCD45_D2+%28CAB96211%29
end
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end
obj|String*|0
end
end|F99150
end
obj|IxMolX
obj|Molecule
obj|BioObject
obj|DBObj||\27:hBDP1_D1 (NP_055184) PTPN18|||||302014800|0|\93:protein tyrosine phosphatase, non-receptor type 18; brain-derived phosphatase [Homo sapiens].
end|2|2|
obj|String*|0
end
obj|String*|14|\64:REVIEWED REFSEQ: This record has been curated by NCBI staff. The|\60:reference sequence was derived from X79568.1 and BI261717.1.|\58:On Jan 25, 2002 this sequence version replaced gi:7657484.||\60:Summary: The protein encoded by this gene is a member of the|\63:protein tyrosine phosphatase (PTP) family. PTPs are known to be|\65:signaling molecules that regulate a variety of cellular processes|\58:including cell growth, differentiation, mitotic cycle, and|\63:oncogenic transformation. This PTP contains a PEST motif, which|\64:often serves as a protein-protein interaction domain, and may be|\66:related to protein intracellular half-live. This gene was found to|\59:be expressed in brain, colon tissues, and several different|\64:tumor-derived cell lines. The bilogical function of this PTP has|\24:not yet been determined.
end
obj|String*|7|\34:REFERENCE   1  (residues 1 to 460)|\69:  AUTHORS   Kim,Y.W., Wang,H., Sures,I., Lammers,R., Martell,K.J. and|\22:            Ullrich,A.|\76:  TITLE     Characterization of the PEST family protein tyrosine phosphatase|            BDP1|\46:  JOURNAL   Oncogene 13 (10), 2275-2279 (1996)|  MEDLINE   97108674
end
obj|Object*|0
end
obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp
end
obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/
end
end|1|0|288
obj|Object*|3
obj|Feature
obj|DBObj||Source_1|||||0|0|
end|269|269|||0|1|288|1|1|1|1|1..460
obj|String*|4|\24:/organism="Homo sapiens"|\21:/db_xref="taxon:9606"|/chromosome="2"|/map="2q21.2"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||Protein_1|||||0|0|\25:brain-derived phosphatase
end|270|270|||0|1|288|1|1|1|1|1..460
obj|String*|3|\57:/product="protein tyrosine phosphatase, non-receptor type|18"|\21:/EC_number="3.1.3.48"
end|0||
obj|Object*|0
end
end
obj|Feature
obj|DBObj||Region_1|||||0|0|PTPc
end|266|266|||0|21|287|1|1|1|1|26..292
obj|String*|3|\53:/region_name="Protein tyrosine phosphatase, catalytic|domain"|\25:/db_xref="CDD:smart00194"
end|0||
obj|Object*|0
end
end
end|\288:dsarsflerlearggregavlagefsdiqacsaawkadgvcstvagsrpenvrknrykdvlpydqtrvilsllqeeghsdyingnfirgvdgslayiatqgplphtlldfwrlvwefgvkvilmacreiengrkrcerywaqeqeplqtglfcitlikekwlnedimlrtlkvtfqkesrsvyqlqymswpdrgvpsspdhmlamveearrlqgsgpeplcvhcsagcgrtgvlctvdyvrqllltqmippdfslfdvvlkmrkqrpaavqteeqyrflyhtvaqmfc|GenPept|
obj|String*|1|NP_055184
end||07-MAY-2003|Homo sapiens (human)
obj|String*|0
end|0
obj|String*|0
end|PRT
obj|String*|0
end
obj|String*|1|Homo sapiens
end
obj|String*|0
end
obj|String*|0
end
obj|String*|12|Eukaryota|Metazoa|Chordata|Craniata|Vertebrata|Euteleostomi|Mammalia|Eutheria|Primates|Catarrhini|Hominidae|Homo
end
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obj|String*|0
end
obj|String*|1|\29:REFSEQ: accession NM_014369.2
end
obj|String*|44|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18
end
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obj|String*|0
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end|2927B70
end
obj|IxMolX
obj|Molecule
obj|BioObject
obj|DBObj||\26:hCD45_D1 (NP_002829) PTPRC|||||302014800|0|\306:protein tyrosine phosphatase, receptor type, C isoform 1 precursor; protein tyrosine phosphatase, receptor type, c polypeptide; leukocyte-common antigen; T200 glycoprotein; human homolog of severe combined immunodeficiency due to PTPRC deficiency; SCID due to PTPRC deficiency; CD45 antigen [Homo sapiens].
end|2|2|
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obj|String*|23|\64:REVIEWED REFSEQ: This record has been curated by NCBI staff. The|\58:reference sequence was derived from Y00638.1 and Y00062.1.|\57:On Feb 8, 2002 this sequence version replaced gi:4506307.||\60:Summary: The protein encoded by this gene is a member of the|\63:protein tyrosine phosphatase (PTP) family. PTPs are known to be|\65:signaling molecules that regulate a variety of cellular processes|\58:including cell growth, differentiation, mitotic cycle, and|\60:oncogenic transformation. This PTP contains an extracellular|\53:domain, a single transmembrane segment and two tandem|\64:intracytoplasmic catalytic domains, and thus belongs to receptor|\62:type PTP. This gene is specifically expressed in hematopoietic|\65:cells. This PTP has been shown to be an essential regulator of T-|\66:and B-cell antigen receptor signaling. It functions through either|\58:direct interaction with components of the antigen receptor|\67:complexes, or by activating various Src family kinases required for|\60:the antigen receptor signaling. This PTP also suppresses JAK|\63:kinases, and thus functions as a regulator of cytokine receptor|\66:signaling. Four alternatively spliced transcripts variants of this|\57:gene, which encode distinct isoforms, have been reported.||\64:Transcript Variant: This variant (1) encodes the longest isoform|(1).
end
obj|String*|212|\35:REFERENCE   1  (residues 1 to 1304)|\44:  AUTHORS   Baldwin,T.A. and Ostergaard,H.L.|\78:  TITLE     The protein-tyrosine phosphatase CD45 reaches the cell surface via|\53:            golgi-dependent and -independent pathways|\55:  JOURNAL   J. Biol. Chem. 277 (52), 50333-50340 (2002)|  MEDLINE   22384317|\69:  REMARK    GeneRIF: reaches the cell surface via Golgi-dependent and|\33:            -independent pathways|\35:REFERENCE   2  (residues 1 to 1304)|\71:  AUTHORS   Harashima,A., Suzuki,M., Okochi,A., Yamamoto,M., Matsuo,Y.,|\47:            Motoda,R., Yoshioka,T. and Orita,K.|\75:  TITLE     CD45 tyrosine phosphatase inhibits erythroid differentiation of|\70:            umbilical cord blood CD34+ cells associated with selective|\31:            inactivation of Lyn|\44:  JOURNAL   Blood 100 (13), 4440-4445 (2002)|  MEDLINE   22340750|\73:  REMARK    GeneRIF: CD45 may play a pivotal role in erythropoiesis. CD45|\70:            tyrosine phosphatase inhibits erythroid differentiation of|\70:            umbilical cord blood CD34+ cells associated with selective|\32:            inactivation of Lyn.|\35:REFERENCE   3  (residues 1 to 1304)|\74:  AUTHORS   Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J.|\72:  TITLE     Intra- and intermolecular interactions between intracellular|\61:            domains of receptor protein-tyrosine phosphatases|\55:  JOURNAL   J. Biol. Chem. 277 (49), 47263-47269 (2002)|  MEDLINE   22344739|\78:  REMARK    GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are|\75:            a common but specific mechanism that is likely to be regulated-|\73:            domain2s and the wedge structures are crucial determinants of|\73:            binding specificity, thus regulating cross-talk between RPTPs|\35:REFERENCE   4  (residues 1 to 1304)|\36:  AUTHORS   Pradhan,D. and Morrow,J.|\75:  TITLE     The spectrin-ankyrin skeleton controls CD45 surface display and|\36:            interleukin-2 production|\43:  JOURNAL   Immunity 17 (3), 303-315 (2002)|  MEDLINE   22241694|\72:  REMARK    GeneRIF: The spectrin-ankyrin skeleton controls CD45 surface|\49:            display and interleukin-2 production.|\35:REFERENCE   5  (residues 1 to 1304)|\73:  AUTHORS   Ballerini,C., Rosati,E., Salvetti,M., Ristori,G., Cannoni,S.,|\63:            Biagioli,T., Massacesi,L., Sorbi,S. and Vergelli,M.|\77:  TITLE     Protein tyrosine phosphatase receptor-type C exon 4 gene mutation|\68:            distribution in an Italian multiple sclerosis population|\51:  JOURNAL   Neurosci. Lett. 328 (3), 325-327 (2002)|  MEDLINE   22142931|\79:  REMARK    GeneRIF: Role of the C-->G mutation in position 77 of exon 4 of the|\77:            protein tyrosine phosphatase receptor-type C (PTPRC) gene, coding|\76:            for the CD45 molecule, for the development of multiple sclerosis|\26:            (MS) in Italy.|\35:REFERENCE   6  (residues 1 to 1304)|\52:  AUTHORS   Yamada,T., Zhu,D., Saxon,A. and Zhang,K.|\79:  TITLE     CD45 controls interleukin-4-mediated IgE class switch recombination|\79:            in human B cells through its function as a Janus kinase phosphatase|\55:  JOURNAL   J. Biol. Chem. 277 (32), 28830-28835 (2002)|  MEDLINE   22151051|\74:  REMARK    GeneRIF: CD45 controls interleukin-4-mediated IgE class switch|\42:            recombination in human B cells|\35:REFERENCE   7  (residues 1 to 1304)|\62:  AUTHORS   Yu,C., Yu,H.S., Sun,K.H., Hsieh,S.C. and Tsai,C.Y.|\70:  TITLE     Anti-CD45 isoform antibodies enhance phagocytosis and gene|\68:            expression of IL-8 and TNF-alpha in human neutrophils by|\76:            differential suppression on protein tyrosine phosphorylation and|\34:            p56lck tyrosine kinase|\53:  JOURNAL   Clin. Exp. Immunol. 129 (1), 78-85 (2002)|  MEDLINE   22095000|\77:  REMARK    GeneRIF: Biological functions of membrane expressed CD45 isoforms|\76:            on PMNs were studied. Cross-linking of CD45 isoforms by specific|\68:            MAbs stimulated different PMN activities by differential|\71:            suppression on protein tyrosine phosphorylation and p56lck.|\35:REFERENCE   8  (residues 1 to 1304)|\78:  AUTHORS   Jacobsen,M., Hoffmann,S., Cepok,S., Stei,S., Ziegler,A., Sommer,N.|\25:            and Hemmer,B.|\77:  TITLE     A novel mutation in PTPRC interferes with splicing and alters the|\48:            structure of the human CD45 molecule|\49:  JOURNAL   Immunogenetics 54 (3), 158-163 (2002)|  MEDLINE   22067726|\76:  REMARK    GeneRIF: a mutation in PTPRC interferes with splicing and alters|\46:            the structure of the CD45 molecule|\35:REFERENCE   9  (residues 1 to 1304)|\43:  AUTHORS   Tchilian,E.Z. and Beverley,P.C.|\38:  TITLE     CD45 in memory and disease|\67:  JOURNAL   Arch. Immunol. Ther. Exp. (Warsz.) 50 (2), 85-93 (2002)|  MEDLINE   22017393|\78:  REMARK    GeneRIF: Role of high and low molecular weight isoforms of CD45 in|\68:            the function of na##ve and memory T lymphocytes. Review.|\35:REFERENCE   10 (residues 1 to 1304)|\70:  AUTHORS   Fajka-Boja,R., Szemes,M., Ion,G., Legradi,A., Caron,M. and|\24:            Monostori,E.|\77:  TITLE     Receptor tyrosine phosphatase, CD45 binds galectin-1 but does not|\56:            mediate its apoptotic signal in T cell lines|\51:  JOURNAL   Immunol. Lett. 82 (1-2), 149-154 (2002)|  MEDLINE   22003829|\77:  REMARK    GeneRIF: Receptor tyrosine phosphatase, CD45 binds galectin-1 but|\65:            does not mediate its apoptotic signal in Jurkat cells|\35:REFERENCE   11 (residues 1 to 1304)|\79:  AUTHORS   Fukuhara,K., Okumura,M., Shiono,H., Inoue,M., Kadota,Y., Miyoshi,S.|\26:            and Matsuda,H.|\76:  TITLE     A study on CD45 isoform expression during T-cell development and|\48:            selection events in the human thymus|\48:  JOURNAL   Hum. Immunol. 63 (5), 394-404 (2002)|  MEDLINE   21972715|\70:  REMARK    GeneRIF: analysis of CD45 isoform expression during T-cell|\57:            development and selection in the human thymus|\35:REFERENCE   12 (residues 1 to 1304)|\38:  AUTHORS   Wu,L., Fu,J. and Shen,S.H.|\64:  TITLE     SKAP55 coupled with CD45 positively regulates T-cell|\48:            receptor-mediated gene transcription|\53:  JOURNAL   Mol. Cell. Biol. 22 (8), 2673-2686 (2002)|  MEDLINE   21907230|\73:  REMARK    GeneRIF: SKAP55 coupled with CD45 positively regulates T-cell|\49:            receptor-mediated gene transcription.|\35:REFERENCE   13 (residues 1 to 1304)|\77:  AUTHORS   Ishikawa,H., Tsuyama,N., Abroun,S., Liu,S., Li,F.J., Taniguchi,O.|\27:            and Kawano,M.M.|\79:  TITLE     Requirements of src family kinase activity associated with CD45 for|\55:            myeloma cell proliferation by interleukin-6|\42:  JOURNAL   Blood 99 (6), 2172-2178 (2002)|  MEDLINE   21866149|\79:  REMARK    GeneRIF: Requirements of src family kinase activity associated with|\64:            CD45 for myeloma cell proliferation by interleukin-6|\35:REFERENCE   14 (residues 1 to 1304)|\66:  AUTHORS   Tchilian,E.Z., Dawes,R., Ramaley,P.A., Whitworth,J.A.,|\72:            Yuldasheva,N., Wells,R.S., Watera,C., French,N., Gilks,C.F.,|\72:            Kunachiwa,W., Ruzibakiev,R., Leetrakool,N., Carrington,C.V.,|\78:            Ramdath,D.D., Gotch,F., Stephens,H.A., Hill,A.V. and Beverley,P.C.|\78:  TITLE     A CD45 polymorphism associated with abnormal splicing is absent in|\31:            African populations|\53:  JOURNAL   Immunogenetics 53 (10-11), 980-983 (2002)|  MEDLINE   21850514|\76:  REMARK    GeneRIF: we examined the frequency of the C77G allele in African|\79:            and Asian populations from countries with high or low prevalence of|\78:            HIV infection; Here we report that the variant CD45 C77G allele is|\41:            absent in African populations|\35:REFERENCE   15 (residues 1 to 1304)|\76:  AUTHORS   Wood,J.P., Bieda,K., Segni,M., Herwig,J., Krause,M., Usadel,K.H.|\28:            and Badenhoop,K.|\79:  TITLE     CD45 exon 4 point mutation does not confer susceptibility to type 1|\48:            diabetes mellitus or Graves' disease|\53:  JOURNAL   Eur. J. Immunogenet. 29 (1), 73-74 (2002)|  MEDLINE   21830605|\79:  REMARK    GeneRIF: CD45 variant (C77G, exon 4) does not confer susceptibility|\45:            to either IDDM or Graves' disease|\35:REFERENCE   16 (residues 1 to 1304)|\71:  AUTHORS   Moro,H., Iwai,K., Mori,N., Watanabe,M., Fukushi,M., Oie,M.,|\78:            Arai,M., Tanaka,Y., Miyawaki,T., Gejyo,F., Arakawa,M. and Fujii,M.|\77:  TITLE     Interleukin-2-dependent but not independent T-cell lines infected|\79:            with human T-cell leukemia virus type 1 selectively express CD45RO,|\53:            a marker for persistent infection in vivo|\46:  JOURNAL   Virus Genes 23 (3), 263-271 (2001)|  MEDLINE   21636965|\78:  REMARK    GeneRIF: role of CD45RO in the persistent HTLV-1 infection in vivo|\35:REFERENCE   17 (residues 1 to 1304)|\74:  AUTHORS   Irie-Sasaki,J., Sasaki,T., Matsumoto,W., Opavsky,A., Cheng,M.,|\79:            Welstead,G., Griffiths,E., Krawczyk,C., Richardson,C.D., Aitken,K.,|\74:            Iscove,N., Koretzky,G., Johnson,P., Liu,P., Rothstein,D.M. and|\26:            Penninger,J.M.|\71:  TITLE     CD45 is a JAK phosphatase and negatively regulates cytokine|\31:            receptor signalling|\45:  JOURNAL   Nature 409 (6818), 349-354 (2001)|  MEDLINE   21069057|\35:REFERENCE   18 (residues 1 to 1304)|\76:  AUTHORS   Goff,L.K., van Soest,S., Timon,M., Tchilian,E. and Beverley,P.C.|\79:  TITLE     Protein tyrosine phosphatase receptor type C polypeptide (PTPRC) on|\79:            human chromosome band 1q31-->q32 localizes with marker D1S413(1) on|\48:            a 610-kb yeast artificial chromosome|\59:  JOURNAL   Cytogenet. Cell Genet. 87 (3-4), 223-224 (1999)|  MEDLINE   20169194|\35:REFERENCE   19 (residues 1 to 1304)|\79:  AUTHORS   Petricoin,E.F. III, Ito,S., Williams,B.L., Audet,S., Stancato,L.F.,|\66:            Gamero,A., Clouse,K., Grimley,P., Weiss,A., Beeler,J.,|\66:            Finbloom,D.S., Shores,E.W., Abraham,R. and Larner,A.C.|\79:  TITLE     Antiproliferative action of interferon-alpha requires components of|\38:            T-cell-receptor signalling|\45:  JOURNAL   Nature 390 (6660), 629-632 (1997)|  MEDLINE   98065953|\35:REFERENCE   20 (residues 1 to 1304)|\74:  AUTHORS   Kaplan,R., Morse,B., Huebner,K., Croce,C., Howk,R., Ravera,M.,|\49:            Ricca,G., Jaye,M. and Schlessinger,J.|\76:  TITLE     Cloning of three human tyrosine phosphatases reveals a multigene|\77:            family of receptor-linked protein-tyrosine-phosphatases expressed|            in brain|\67:  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (18), 7000-7004 (1990)|  MEDLINE   90384936|\35:REFERENCE   21 (residues 1 to 1304)|\63:  AUTHORS   Schraven,B., Samstag,Y., Altevogt,P. and Meuer,S.C.|\62:  TITLE     Association of CD2 and CD45 on human T lymphocytes|\43:  JOURNAL   Nature 345 (6270), 71-74 (1990)|  MEDLINE   90231464|\35:REFERENCE   22 (residues 1 to 1304)|\39:  AUTHORS   Pingel,J.T. and Thomas,M.L.|\70:  TITLE     Evidence that the leukocyte-common antigen is required for|\54:            antigen-induced T lymphocyte proliferation|\41:  JOURNAL   Cell 58 (6), 1055-1065 (1989)|  MEDLINE   89376557|\35:REFERENCE   23 (residues 1 to 1304)|\67:  AUTHORS   Charbonneau,H., Tonks,N.K., Walsh,K.A. and Fischer,E.H.|\75:  TITLE     The leukocyte common antigen (CD45): a putative receptor-linked|\40:            protein tyrosine phosphatase|\67:  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 85 (19), 7182-7186 (1988)|  MEDLINE   89017162|\35:REFERENCE   24 (residues 1 to 1304)|\72:  AUTHORS   Streuli,M., Hall,L.R., Saga,Y., Schlossman,S.F. and Saito,H.|\79:  TITLE     Differential usage of three exons generates at least five different|\58:            mRNAs encoding human leukocyte common antigens|\50:  JOURNAL   J. Exp. Med. 166 (5), 1548-1566 (1987)|  MEDLINE   88061067|\35:REFERENCE   25 (residues 1 to 1304)|\68:  AUTHORS   Ralph,S.J., Thomas,M.L., Morton,C.C. and Trowbridge,I.S.|\76:  TITLE     Structural variants of human T200 glycoprotein (leukocyte-common|            antigen)|\43:  JOURNAL   EMBO J. 6 (5), 1251-1257 (1987)|  MEDLINE   87275816
end
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obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp
end
obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/
end
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obj|String*|4|\24:/organism="Homo sapiens"|\21:/db_xref="taxon:9606"|/chromosome="1"|/map="1q31-q32"
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obj|Feature
obj|DBObj||Protein_1|||||0|0|\222:protein tyrosine phosphatase, receptor type, c polypeptide; leukocyte-common antigen; T200 glycoprotein; human homolog of severe combined immunodeficiency due to PTPRC deficiency; SCID due to PTPRC deficiency; CD45 antigen
end|270|270|||0|1|279|1|1|1|1|1..1304
obj|String*|3|\56:/product="protein tyrosine phosphatase, receptor type, C|isoform 1 precursor"|\21:/EC_number="3.1.3.48"
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obj|String*|3|\53:/region_name="Protein tyrosine phosphatase, catalytic|domain"|\25:/db_xref="CDD:smart00194"
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end|\279:dilletykrkiadegrlflaefqsiprvfskfpikearkpfnqnknryvdilpydynrvelseingdagsnyinasyidgfkeprkyiaaqgprdetvddfwrmiweqkatvivmvtrceegnrnkcaeywpsmeegtrafgdvvvkinqhkrcpdyiiqklnivnkkekatgrevthiqftswpdhgvpedphlllklrrrvnafsnffsgpivvhcsagvgrtgtyigidamlegleaenkvdvygyvvklrrqrclmvqveaqyilihqalveynq|GenPept|
obj|String*|1|NP_002829
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obj|String*|1|\29:REFSEQ: accession NM_002838.2
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obj|String*|48|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC
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obj|DBObj||\26:hCD45_D2 (NP_002829) PTPRC|||||302014800|0|\306:protein tyrosine phosphatase, receptor type, C isoform 1 precursor; protein tyrosine phosphatase, receptor type, c polypeptide; leukocyte-common antigen; T200 glycoprotein; human homolog of severe combined immunodeficiency due to PTPRC deficiency; SCID due to PTPRC deficiency; CD45 antigen [Homo sapiens].
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obj|String*|23|\64:REVIEWED REFSEQ: This record has been curated by NCBI staff. The|\58:reference sequence was derived from Y00638.1 and Y00062.1.|\57:On Feb 8, 2002 this sequence version replaced gi:4506307.||\60:Summary: The protein encoded by this gene is a member of the|\63:protein tyrosine phosphatase (PTP) family. PTPs are known to be|\65:signaling molecules that regulate a variety of cellular processes|\58:including cell growth, differentiation, mitotic cycle, and|\60:oncogenic transformation. This PTP contains an extracellular|\53:domain, a single transmembrane segment and two tandem|\64:intracytoplasmic catalytic domains, and thus belongs to receptor|\62:type PTP. This gene is specifically expressed in hematopoietic|\65:cells. This PTP has been shown to be an essential regulator of T-|\66:and B-cell antigen receptor signaling. It functions through either|\58:direct interaction with components of the antigen receptor|\67:complexes, or by activating various Src family kinases required for|\60:the antigen receptor signaling. This PTP also suppresses JAK|\63:kinases, and thus functions as a regulator of cytokine receptor|\66:signaling. Four alternatively spliced transcripts variants of this|\57:gene, which encode distinct isoforms, have been reported.||\64:Transcript Variant: This variant (1) encodes the longest isoform|(1).
end
obj|String*|212|\35:REFERENCE   1  (residues 1 to 1304)|\44:  AUTHORS   Baldwin,T.A. and Ostergaard,H.L.|\78:  TITLE     The protein-tyrosine phosphatase CD45 reaches the cell surface via|\53:            golgi-dependent and -independent pathways|\55:  JOURNAL   J. Biol. Chem. 277 (52), 50333-50340 (2002)|  MEDLINE   22384317|\69:  REMARK    GeneRIF: reaches the cell surface via Golgi-dependent and|\33:            -independent pathways|\35:REFERENCE   2  (residues 1 to 1304)|\71:  AUTHORS   Harashima,A., Suzuki,M., Okochi,A., Yamamoto,M., Matsuo,Y.,|\47:            Motoda,R., Yoshioka,T. and Orita,K.|\75:  TITLE     CD45 tyrosine phosphatase inhibits erythroid differentiation of|\70:            umbilical cord blood CD34+ cells associated with selective|\31:            inactivation of Lyn|\44:  JOURNAL   Blood 100 (13), 4440-4445 (2002)|  MEDLINE   22340750|\73:  REMARK    GeneRIF: CD45 may play a pivotal role in erythropoiesis. CD45|\70:            tyrosine phosphatase inhibits erythroid differentiation of|\70:            umbilical cord blood CD34+ cells associated with selective|\32:            inactivation of Lyn.|\35:REFERENCE   3  (residues 1 to 1304)|\74:  AUTHORS   Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J.|\72:  TITLE     Intra- and intermolecular interactions between intracellular|\61:            domains of receptor protein-tyrosine phosphatases|\55:  JOURNAL   J. Biol. Chem. 277 (49), 47263-47269 (2002)|  MEDLINE   22344739|\78:  REMARK    GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are|\75:            a common but specific mechanism that is likely to be regulated-|\73:            domain2s and the wedge structures are crucial determinants of|\73:            binding specificity, thus regulating cross-talk between RPTPs|\35:REFERENCE   4  (residues 1 to 1304)|\36:  AUTHORS   Pradhan,D. and Morrow,J.|\75:  TITLE     The spectrin-ankyrin skeleton controls CD45 surface display and|\36:            interleukin-2 production|\43:  JOURNAL   Immunity 17 (3), 303-315 (2002)|  MEDLINE   22241694|\72:  REMARK    GeneRIF: The spectrin-ankyrin skeleton controls CD45 surface|\49:            display and interleukin-2 production.|\35:REFERENCE   5  (residues 1 to 1304)|\73:  AUTHORS   Ballerini,C., Rosati,E., Salvetti,M., Ristori,G., Cannoni,S.,|\63:            Biagioli,T., Massacesi,L., Sorbi,S. and Vergelli,M.|\77:  TITLE     Protein tyrosine phosphatase receptor-type C exon 4 gene mutation|\68:            distribution in an Italian multiple sclerosis population|\51:  JOURNAL   Neurosci. Lett. 328 (3), 325-327 (2002)|  MEDLINE   22142931|\79:  REMARK    GeneRIF: Role of the C-->G mutation in position 77 of exon 4 of the|\77:            protein tyrosine phosphatase receptor-type C (PTPRC) gene, coding|\76:            for the CD45 molecule, for the development of multiple sclerosis|\26:            (MS) in Italy.|\35:REFERENCE   6  (residues 1 to 1304)|\52:  AUTHORS   Yamada,T., Zhu,D., Saxon,A. and Zhang,K.|\79:  TITLE     CD45 controls interleukin-4-mediated IgE class switch recombination|\79:            in human B cells through its function as a Janus kinase phosphatase|\55:  JOURNAL   J. Biol. Chem. 277 (32), 28830-28835 (2002)|  MEDLINE   22151051|\74:  REMARK    GeneRIF: CD45 controls interleukin-4-mediated IgE class switch|\42:            recombination in human B cells|\35:REFERENCE   7  (residues 1 to 1304)|\62:  AUTHORS   Yu,C., Yu,H.S., Sun,K.H., Hsieh,S.C. and Tsai,C.Y.|\70:  TITLE     Anti-CD45 isoform antibodies enhance phagocytosis and gene|\68:            expression of IL-8 and TNF-alpha in human neutrophils by|\76:            differential suppression on protein tyrosine phosphorylation and|\34:            p56lck tyrosine kinase|\53:  JOURNAL   Clin. Exp. Immunol. 129 (1), 78-85 (2002)|  MEDLINE   22095000|\77:  REMARK    GeneRIF: Biological functions of membrane expressed CD45 isoforms|\76:            on PMNs were studied. Cross-linking of CD45 isoforms by specific|\68:            MAbs stimulated different PMN activities by differential|\71:            suppression on protein tyrosine phosphorylation and p56lck.|\35:REFERENCE   8  (residues 1 to 1304)|\78:  AUTHORS   Jacobsen,M., Hoffmann,S., Cepok,S., Stei,S., Ziegler,A., Sommer,N.|\25:            and Hemmer,B.|\77:  TITLE     A novel mutation in PTPRC interferes with splicing and alters the|\48:            structure of the human CD45 molecule|\49:  JOURNAL   Immunogenetics 54 (3), 158-163 (2002)|  MEDLINE   22067726|\76:  REMARK    GeneRIF: a mutation in PTPRC interferes with splicing and alters|\46:            the structure of the CD45 molecule|\35:REFERENCE   9  (residues 1 to 1304)|\43:  AUTHORS   Tchilian,E.Z. and Beverley,P.C.|\38:  TITLE     CD45 in memory and disease|\67:  JOURNAL   Arch. Immunol. Ther. Exp. (Warsz.) 50 (2), 85-93 (2002)|  MEDLINE   22017393|\78:  REMARK    GeneRIF: Role of high and low molecular weight isoforms of CD45 in|\68:            the function of na##ve and memory T lymphocytes. Review.|\35:REFERENCE   10 (residues 1 to 1304)|\70:  AUTHORS   Fajka-Boja,R., Szemes,M., Ion,G., Legradi,A., Caron,M. and|\24:            Monostori,E.|\77:  TITLE     Receptor tyrosine phosphatase, CD45 binds galectin-1 but does not|\56:            mediate its apoptotic signal in T cell lines|\51:  JOURNAL   Immunol. Lett. 82 (1-2), 149-154 (2002)|  MEDLINE   22003829|\77:  REMARK    GeneRIF: Receptor tyrosine phosphatase, CD45 binds galectin-1 but|\65:            does not mediate its apoptotic signal in Jurkat cells|\35:REFERENCE   11 (residues 1 to 1304)|\79:  AUTHORS   Fukuhara,K., Okumura,M., Shiono,H., Inoue,M., Kadota,Y., Miyoshi,S.|\26:            and Matsuda,H.|\76:  TITLE     A study on CD45 isoform expression during T-cell development and|\48:            selection events in the human thymus|\48:  JOURNAL   Hum. Immunol. 63 (5), 394-404 (2002)|  MEDLINE   21972715|\70:  REMARK    GeneRIF: analysis of CD45 isoform expression during T-cell|\57:            development and selection in the human thymus|\35:REFERENCE   12 (residues 1 to 1304)|\38:  AUTHORS   Wu,L., Fu,J. and Shen,S.H.|\64:  TITLE     SKAP55 coupled with CD45 positively regulates T-cell|\48:            receptor-mediated gene transcription|\53:  JOURNAL   Mol. Cell. Biol. 22 (8), 2673-2686 (2002)|  MEDLINE   21907230|\73:  REMARK    GeneRIF: SKAP55 coupled with CD45 positively regulates T-cell|\49:            receptor-mediated gene transcription.|\35:REFERENCE   13 (residues 1 to 1304)|\77:  AUTHORS   Ishikawa,H., Tsuyama,N., Abroun,S., Liu,S., Li,F.J., Taniguchi,O.|\27:            and Kawano,M.M.|\79:  TITLE     Requirements of src family kinase activity associated with CD45 for|\55:            myeloma cell proliferation by interleukin-6|\42:  JOURNAL   Blood 99 (6), 2172-2178 (2002)|  MEDLINE   21866149|\79:  REMARK    GeneRIF: Requirements of src family kinase activity associated with|\64:            CD45 for myeloma cell proliferation by interleukin-6|\35:REFERENCE   14 (residues 1 to 1304)|\66:  AUTHORS   Tchilian,E.Z., Dawes,R., Ramaley,P.A., Whitworth,J.A.,|\72:            Yuldasheva,N., Wells,R.S., Watera,C., French,N., Gilks,C.F.,|\72:            Kunachiwa,W., Ruzibakiev,R., Leetrakool,N., Carrington,C.V.,|\78:            Ramdath,D.D., Gotch,F., Stephens,H.A., Hill,A.V. and Beverley,P.C.|\78:  TITLE     A CD45 polymorphism associated with abnormal splicing is absent in|\31:            African populations|\53:  JOURNAL   Immunogenetics 53 (10-11), 980-983 (2002)|  MEDLINE   21850514|\76:  REMARK    GeneRIF: we examined the frequency of the C77G allele in African|\79:            and Asian populations from countries with high or low prevalence of|\78:            HIV infection; Here we report that the variant CD45 C77G allele is|\41:            absent in African populations|\35:REFERENCE   15 (residues 1 to 1304)|\76:  AUTHORS   Wood,J.P., Bieda,K., Segni,M., Herwig,J., Krause,M., Usadel,K.H.|\28:            and Badenhoop,K.|\79:  TITLE     CD45 exon 4 point mutation does not confer susceptibility to type 1|\48:            diabetes mellitus or Graves' disease|\53:  JOURNAL   Eur. J. Immunogenet. 29 (1), 73-74 (2002)|  MEDLINE   21830605|\79:  REMARK    GeneRIF: CD45 variant (C77G, exon 4) does not confer susceptibility|\45:            to either IDDM or Graves' disease|\35:REFERENCE   16 (residues 1 to 1304)|\71:  AUTHORS   Moro,H., Iwai,K., Mori,N., Watanabe,M., Fukushi,M., Oie,M.,|\78:            Arai,M., Tanaka,Y., Miyawaki,T., Gejyo,F., Arakawa,M. and Fujii,M.|\77:  TITLE     Interleukin-2-dependent but not independent T-cell lines infected|\79:            with human T-cell leukemia virus type 1 selectively express CD45RO,|\53:            a marker for persistent infection in vivo|\46:  JOURNAL   Virus Genes 23 (3), 263-271 (2001)|  MEDLINE   21636965|\78:  REMARK    GeneRIF: role of CD45RO in the persistent HTLV-1 infection in vivo|\35:REFERENCE   17 (residues 1 to 1304)|\74:  AUTHORS   Irie-Sasaki,J., Sasaki,T., Matsumoto,W., Opavsky,A., Cheng,M.,|\79:            Welstead,G., Griffiths,E., Krawczyk,C., Richardson,C.D., Aitken,K.,|\74:            Iscove,N., Koretzky,G., Johnson,P., Liu,P., Rothstein,D.M. and|\26:            Penninger,J.M.|\71:  TITLE     CD45 is a JAK phosphatase and negatively regulates cytokine|\31:            receptor signalling|\45:  JOURNAL   Nature 409 (6818), 349-354 (2001)|  MEDLINE   21069057|\35:REFERENCE   18 (residues 1 to 1304)|\76:  AUTHORS   Goff,L.K., van Soest,S., Timon,M., Tchilian,E. and Beverley,P.C.|\79:  TITLE     Protein tyrosine phosphatase receptor type C polypeptide (PTPRC) on|\79:            human chromosome band 1q31-->q32 localizes with marker D1S413(1) on|\48:            a 610-kb yeast artificial chromosome|\59:  JOURNAL   Cytogenet. Cell Genet. 87 (3-4), 223-224 (1999)|  MEDLINE   20169194|\35:REFERENCE   19 (residues 1 to 1304)|\79:  AUTHORS   Petricoin,E.F. III, Ito,S., Williams,B.L., Audet,S., Stancato,L.F.,|\66:            Gamero,A., Clouse,K., Grimley,P., Weiss,A., Beeler,J.,|\66:            Finbloom,D.S., Shores,E.W., Abraham,R. and Larner,A.C.|\79:  TITLE     Antiproliferative action of interferon-alpha requires components of|\38:            T-cell-receptor signalling|\45:  JOURNAL   Nature 390 (6660), 629-632 (1997)|  MEDLINE   98065953|\35:REFERENCE   20 (residues 1 to 1304)|\74:  AUTHORS   Kaplan,R., Morse,B., Huebner,K., Croce,C., Howk,R., Ravera,M.,|\49:            Ricca,G., Jaye,M. and Schlessinger,J.|\76:  TITLE     Cloning of three human tyrosine phosphatases reveals a multigene|\77:            family of receptor-linked protein-tyrosine-phosphatases expressed|            in brain|\67:  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (18), 7000-7004 (1990)|  MEDLINE   90384936|\35:REFERENCE   21 (residues 1 to 1304)|\63:  AUTHORS   Schraven,B., Samstag,Y., Altevogt,P. and Meuer,S.C.|\62:  TITLE     Association of CD2 and CD45 on human T lymphocytes|\43:  JOURNAL   Nature 345 (6270), 71-74 (1990)|  MEDLINE   90231464|\35:REFERENCE   22 (residues 1 to 1304)|\39:  AUTHORS   Pingel,J.T. and Thomas,M.L.|\70:  TITLE     Evidence that the leukocyte-common antigen is required for|\54:            antigen-induced T lymphocyte proliferation|\41:  JOURNAL   Cell 58 (6), 1055-1065 (1989)|  MEDLINE   89376557|\35:REFERENCE   23 (residues 1 to 1304)|\67:  AUTHORS   Charbonneau,H., Tonks,N.K., Walsh,K.A. and Fischer,E.H.|\75:  TITLE     The leukocyte common antigen (CD45): a putative receptor-linked|\40:            protein tyrosine phosphatase|\67:  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 85 (19), 7182-7186 (1988)|  MEDLINE   89017162|\35:REFERENCE   24 (residues 1 to 1304)|\72:  AUTHORS   Streuli,M., Hall,L.R., Saga,Y., Schl