|AlignmentProject obj|Project|2 obj|MolList|2 obj|Object*|37 obj|IxMolX obj|Molecule obj|BioObject obj|DBObj||\27:hBDP1_D1 (NP_055184) PTPN18|||||302014800|0|\93:protein tyrosine phosphatase, non-receptor type 18; brain-derived phosphatase [Homo sapiens]. end|2|2| obj|String*|0 end obj|String*|14|\64:REVIEWED REFSEQ: This record has been curated by NCBI staff. The|\60:reference sequence was derived from X79568.1 and BI261717.1.|\58:On Jan 25, 2002 this sequence version replaced gi:7657484.||\60:Summary: The protein encoded by this gene is a member of the|\63:protein tyrosine phosphatase (PTP) family. PTPs are known to be|\65:signaling molecules that regulate a variety of cellular processes|\58:including cell growth, differentiation, mitotic cycle, and|\63:oncogenic transformation. This PTP contains a PEST motif, which|\64:often serves as a protein-protein interaction domain, and may be|\66:related to protein intracellular half-live. This gene was found to|\59:be expressed in brain, colon tissues, and several different|\64:tumor-derived cell lines. The bilogical function of this PTP has|\24:not yet been determined. end obj|String*|7|\34:REFERENCE 1 (residues 1 to 460)|\69: AUTHORS Kim,Y.W., Wang,H., Sures,I., Lammers,R., Martell,K.J. and|\22: Ullrich,A.|\76: TITLE Characterization of the PEST family protein tyrosine phosphatase| BDP1|\46: JOURNAL Oncogene 13 (10), 2275-2279 (1996)| MEDLINE 97108674 end obj|Object*|0 end obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp end obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/ end end|1|0|288 obj|Object*|3 obj|Feature obj|DBObj||Source_1|||||0|0| end|269|269|||0|1|288|1|1|1|1|1..288 obj|String*|4|\24:/organism="Homo sapiens"|\21:/db_xref="taxon:9606"|/chromosome="2"|/map="2q21.2" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Protein_1|||||0|0|\25:brain-derived phosphatase end|270|270|||0|1|288|1|1|1|1|1..288 obj|String*|3|\57:/product="protein tyrosine phosphatase, non-receptor type|18"|\21:/EC_number="3.1.3.48" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Region_1|||||0|0|PTPc end|266|266|||0|21|287|1|1|1|1|21..287 obj|String*|3|\53:/region_name="Protein tyrosine phosphatase, catalytic|domain"|\25:/db_xref="CDD:smart00194" end|0|| obj|Object*|0 end end end|\288:dsarsflerlearggregavlagefsdiqacsaawkadgvcstvagsrpenvrknrykdvlpydqtrvilsllqeeghsdyingnfirgvdgslayiatqgplphtlldfwrlvwefgvkvilmacreiengrkrcerywaqeqeplqtglfcitlikekwlnedimlrtlkvtfqkesrsvyqlqymswpdrgvpsspdhmlamveearrlqgsgpeplcvhcsagcgrtgvlctvdyvrqllltqmippdfslfdvvlkmrkqrpaavqteeqyrflyhtvaqmfc|GenPept| obj|String*|1|NP_055184 end||17-MAY-2003|\21:Homo sapiens (human). obj|String*|0 end|0 obj|String*|0 end|PRT obj|String*|0 end obj|String*|1|Homo sapiens end obj|String*|0 end obj|String*|0 end obj|String*|12|Eukaryota|Metazoa|Chordata|Craniata|Vertebrata|Euteleostomi|Mammalia|Eutheria|Primates|Catarrhini|Hominidae|Homo end obj|Object*|0 end obj|String*|0 end obj|String*|0 end obj|String*|1|\29:REFSEQ: accession NM_014369.2 end obj|String*|21|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18|\53:VNTI URL:vnti:protein/hBDP1_D1+%28NP_055184%29+PTPN18 end obj|String*|0 end obj|String*|0 end end|F89F30 end obj|IxMolX obj|Molecule obj|BioObject obj|DBObj||\26:hCD45_D1 (NP_002829) PTPRC|||||302014800|0|\306:protein tyrosine phosphatase, receptor type, C isoform 1 precursor; protein tyrosine phosphatase, receptor type, c polypeptide; leukocyte-common antigen; T200 glycoprotein; human homolog of severe combined immunodeficiency due to PTPRC deficiency; SCID due to PTPRC deficiency; CD45 antigen [Homo sapiens]. end|2|2| obj|String*|0 end obj|String*|23|\64:REVIEWED REFSEQ: This record has been curated by NCBI staff. The|\58:reference sequence was derived from Y00638.1 and Y00062.1.|\57:On Feb 8, 2002 this sequence version replaced gi:4506307.||\60:Summary: The protein encoded by this gene is a member of the|\63:protein tyrosine phosphatase (PTP) family. PTPs are known to be|\65:signaling molecules that regulate a variety of cellular processes|\58:including cell growth, differentiation, mitotic cycle, and|\60:oncogenic transformation. This PTP contains an extracellular|\53:domain, a single transmembrane segment and two tandem|\64:intracytoplasmic catalytic domains, and thus belongs to receptor|\62:type PTP. This gene is specifically expressed in hematopoietic|\65:cells. This PTP has been shown to be an essential regulator of T-|\66:and B-cell antigen receptor signaling. It functions through either|\58:direct interaction with components of the antigen receptor|\67:complexes, or by activating various Src family kinases required for|\60:the antigen receptor signaling. This PTP also suppresses JAK|\63:kinases, and thus functions as a regulator of cytokine receptor|\66:signaling. Four alternatively spliced transcripts variants of this|\57:gene, which encode distinct isoforms, have been reported.||\64:Transcript Variant: This variant (1) encodes the longest isoform|(1). end obj|String*|212|\35:REFERENCE 1 (residues 1 to 1304)|\44: AUTHORS Baldwin,T.A. and Ostergaard,H.L.|\78: TITLE The protein-tyrosine phosphatase CD45 reaches the cell surface via|\53: golgi-dependent and -independent pathways|\55: JOURNAL J. Biol. Chem. 277 (52), 50333-50340 (2002)| MEDLINE 22384317|\69: REMARK GeneRIF: reaches the cell surface via Golgi-dependent and|\33: -independent pathways|\35:REFERENCE 2 (residues 1 to 1304)|\71: AUTHORS Harashima,A., Suzuki,M., Okochi,A., Yamamoto,M., Matsuo,Y.,|\47: Motoda,R., Yoshioka,T. and Orita,K.|\75: TITLE CD45 tyrosine phosphatase inhibits erythroid differentiation of|\70: umbilical cord blood CD34+ cells associated with selective|\31: inactivation of Lyn|\44: JOURNAL Blood 100 (13), 4440-4445 (2002)| MEDLINE 22340750|\73: REMARK GeneRIF: CD45 may play a pivotal role in erythropoiesis. CD45|\70: tyrosine phosphatase inhibits erythroid differentiation of|\70: umbilical cord blood CD34+ cells associated with selective|\32: inactivation of Lyn.|\35:REFERENCE 3 (residues 1 to 1304)|\74: AUTHORS Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J.|\72: TITLE Intra- and intermolecular interactions between intracellular|\61: domains of receptor protein-tyrosine phosphatases|\55: JOURNAL J. Biol. Chem. 277 (49), 47263-47269 (2002)| MEDLINE 22344739|\78: REMARK GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are|\75: a common but specific mechanism that is likely to be regulated-|\73: domain2s and the wedge structures are crucial determinants of|\73: binding specificity, thus regulating cross-talk between RPTPs|\35:REFERENCE 4 (residues 1 to 1304)|\36: AUTHORS Pradhan,D. and Morrow,J.|\75: TITLE The spectrin-ankyrin skeleton controls CD45 surface display and|\36: interleukin-2 production|\43: JOURNAL Immunity 17 (3), 303-315 (2002)| MEDLINE 22241694|\72: REMARK GeneRIF: The spectrin-ankyrin skeleton controls CD45 surface|\49: display and interleukin-2 production.|\35:REFERENCE 5 (residues 1 to 1304)|\73: AUTHORS Ballerini,C., Rosati,E., Salvetti,M., Ristori,G., Cannoni,S.,|\63: Biagioli,T., Massacesi,L., Sorbi,S. and Vergelli,M.|\77: TITLE Protein tyrosine phosphatase receptor-type C exon 4 gene mutation|\68: distribution in an Italian multiple sclerosis population|\51: JOURNAL Neurosci. Lett. 328 (3), 325-327 (2002)| MEDLINE 22142931|\79: REMARK GeneRIF: Role of the C-->G mutation in position 77 of exon 4 of the|\77: protein tyrosine phosphatase receptor-type C (PTPRC) gene, coding|\76: for the CD45 molecule, for the development of multiple sclerosis|\26: (MS) in Italy.|\35:REFERENCE 6 (residues 1 to 1304)|\52: AUTHORS Yamada,T., Zhu,D., Saxon,A. and Zhang,K.|\79: TITLE CD45 controls interleukin-4-mediated IgE class switch recombination|\79: in human B cells through its function as a Janus kinase phosphatase|\55: JOURNAL J. Biol. Chem. 277 (32), 28830-28835 (2002)| MEDLINE 22151051|\74: REMARK GeneRIF: CD45 controls interleukin-4-mediated IgE class switch|\42: recombination in human B cells|\35:REFERENCE 7 (residues 1 to 1304)|\62: AUTHORS Yu,C., Yu,H.S., Sun,K.H., Hsieh,S.C. and Tsai,C.Y.|\70: TITLE Anti-CD45 isoform antibodies enhance phagocytosis and gene|\68: expression of IL-8 and TNF-alpha in human neutrophils by|\76: differential suppression on protein tyrosine phosphorylation and|\34: p56lck tyrosine kinase|\53: JOURNAL Clin. Exp. Immunol. 129 (1), 78-85 (2002)| MEDLINE 22095000|\77: REMARK GeneRIF: Biological functions of membrane expressed CD45 isoforms|\76: on PMNs were studied. Cross-linking of CD45 isoforms by specific|\68: MAbs stimulated different PMN activities by differential|\71: suppression on protein tyrosine phosphorylation and p56lck.|\35:REFERENCE 8 (residues 1 to 1304)|\78: AUTHORS Jacobsen,M., Hoffmann,S., Cepok,S., Stei,S., Ziegler,A., Sommer,N.|\25: and Hemmer,B.|\77: TITLE A novel mutation in PTPRC interferes with splicing and alters the|\48: structure of the human CD45 molecule|\49: JOURNAL Immunogenetics 54 (3), 158-163 (2002)| MEDLINE 22067726|\76: REMARK GeneRIF: a mutation in PTPRC interferes with splicing and alters|\46: the structure of the CD45 molecule|\35:REFERENCE 9 (residues 1 to 1304)|\43: AUTHORS Tchilian,E.Z. and Beverley,P.C.|\38: TITLE CD45 in memory and disease|\67: JOURNAL Arch. Immunol. Ther. Exp. (Warsz.) 50 (2), 85-93 (2002)| MEDLINE 22017393|\78: REMARK GeneRIF: Role of high and low molecular weight isoforms of CD45 in|\68: the function of na##ve and memory T lymphocytes. Review.|\35:REFERENCE 10 (residues 1 to 1304)|\70: AUTHORS Fajka-Boja,R., Szemes,M., Ion,G., Legradi,A., Caron,M. and|\24: Monostori,E.|\77: TITLE Receptor tyrosine phosphatase, CD45 binds galectin-1 but does not|\56: mediate its apoptotic signal in T cell lines|\51: JOURNAL Immunol. Lett. 82 (1-2), 149-154 (2002)| MEDLINE 22003829|\77: REMARK GeneRIF: Receptor tyrosine phosphatase, CD45 binds galectin-1 but|\65: does not mediate its apoptotic signal in Jurkat cells|\35:REFERENCE 11 (residues 1 to 1304)|\79: AUTHORS Fukuhara,K., Okumura,M., Shiono,H., Inoue,M., Kadota,Y., Miyoshi,S.|\26: and Matsuda,H.|\76: TITLE A study on CD45 isoform expression during T-cell development and|\48: selection events in the human thymus|\48: JOURNAL Hum. Immunol. 63 (5), 394-404 (2002)| MEDLINE 21972715|\70: REMARK GeneRIF: analysis of CD45 isoform expression during T-cell|\57: development and selection in the human thymus|\35:REFERENCE 12 (residues 1 to 1304)|\38: AUTHORS Wu,L., Fu,J. and Shen,S.H.|\64: TITLE SKAP55 coupled with CD45 positively regulates T-cell|\48: receptor-mediated gene transcription|\53: JOURNAL Mol. Cell. Biol. 22 (8), 2673-2686 (2002)| MEDLINE 21907230|\73: REMARK GeneRIF: SKAP55 coupled with CD45 positively regulates T-cell|\49: receptor-mediated gene transcription.|\35:REFERENCE 13 (residues 1 to 1304)|\77: AUTHORS Ishikawa,H., Tsuyama,N., Abroun,S., Liu,S., Li,F.J., Taniguchi,O.|\27: and Kawano,M.M.|\79: TITLE Requirements of src family kinase activity associated with CD45 for|\55: myeloma cell proliferation by interleukin-6|\42: JOURNAL Blood 99 (6), 2172-2178 (2002)| MEDLINE 21866149|\79: REMARK GeneRIF: Requirements of src family kinase activity associated with|\64: CD45 for myeloma cell proliferation by interleukin-6|\35:REFERENCE 14 (residues 1 to 1304)|\66: AUTHORS Tchilian,E.Z., Dawes,R., Ramaley,P.A., Whitworth,J.A.,|\72: Yuldasheva,N., Wells,R.S., Watera,C., French,N., Gilks,C.F.,|\72: Kunachiwa,W., Ruzibakiev,R., Leetrakool,N., Carrington,C.V.,|\78: Ramdath,D.D., Gotch,F., Stephens,H.A., Hill,A.V. and Beverley,P.C.|\78: TITLE A CD45 polymorphism associated with abnormal splicing is absent in|\31: African populations|\53: JOURNAL Immunogenetics 53 (10-11), 980-983 (2002)| MEDLINE 21850514|\76: REMARK GeneRIF: we examined the frequency of the C77G allele in African|\79: and Asian populations from countries with high or low prevalence of|\78: HIV infection; Here we report that the variant CD45 C77G allele is|\41: absent in African populations|\35:REFERENCE 15 (residues 1 to 1304)|\76: AUTHORS Wood,J.P., Bieda,K., Segni,M., Herwig,J., Krause,M., Usadel,K.H.|\28: and Badenhoop,K.|\79: TITLE CD45 exon 4 point mutation does not confer susceptibility to type 1|\48: diabetes mellitus or Graves' disease|\53: JOURNAL Eur. J. Immunogenet. 29 (1), 73-74 (2002)| MEDLINE 21830605|\79: REMARK GeneRIF: CD45 variant (C77G, exon 4) does not confer susceptibility|\45: to either IDDM or Graves' disease|\35:REFERENCE 16 (residues 1 to 1304)|\71: AUTHORS Moro,H., Iwai,K., Mori,N., Watanabe,M., Fukushi,M., Oie,M.,|\78: Arai,M., Tanaka,Y., Miyawaki,T., Gejyo,F., Arakawa,M. and Fujii,M.|\77: TITLE Interleukin-2-dependent but not independent T-cell lines infected|\79: with human T-cell leukemia virus type 1 selectively express CD45RO,|\53: a marker for persistent infection in vivo|\46: JOURNAL Virus Genes 23 (3), 263-271 (2001)| MEDLINE 21636965|\78: REMARK GeneRIF: role of CD45RO in the persistent HTLV-1 infection in vivo|\35:REFERENCE 17 (residues 1 to 1304)|\74: AUTHORS Irie-Sasaki,J., Sasaki,T., Matsumoto,W., Opavsky,A., Cheng,M.,|\79: Welstead,G., Griffiths,E., Krawczyk,C., Richardson,C.D., Aitken,K.,|\74: Iscove,N., Koretzky,G., Johnson,P., Liu,P., Rothstein,D.M. and|\26: Penninger,J.M.|\71: TITLE CD45 is a JAK phosphatase and negatively regulates cytokine|\31: receptor signalling|\45: JOURNAL Nature 409 (6818), 349-354 (2001)| MEDLINE 21069057|\35:REFERENCE 18 (residues 1 to 1304)|\76: AUTHORS Goff,L.K., van Soest,S., Timon,M., Tchilian,E. and Beverley,P.C.|\79: TITLE Protein tyrosine phosphatase receptor type C polypeptide (PTPRC) on|\79: human chromosome band 1q31-->q32 localizes with marker D1S413(1) on|\48: a 610-kb yeast artificial chromosome|\59: JOURNAL Cytogenet. Cell Genet. 87 (3-4), 223-224 (1999)| MEDLINE 20169194|\35:REFERENCE 19 (residues 1 to 1304)|\79: AUTHORS Petricoin,E.F. III, Ito,S., Williams,B.L., Audet,S., Stancato,L.F.,|\66: Gamero,A., Clouse,K., Grimley,P., Weiss,A., Beeler,J.,|\66: Finbloom,D.S., Shores,E.W., Abraham,R. and Larner,A.C.|\79: TITLE Antiproliferative action of interferon-alpha requires components of|\38: T-cell-receptor signalling|\45: JOURNAL Nature 390 (6660), 629-632 (1997)| MEDLINE 98065953|\35:REFERENCE 20 (residues 1 to 1304)|\74: AUTHORS Kaplan,R., Morse,B., Huebner,K., Croce,C., Howk,R., Ravera,M.,|\49: Ricca,G., Jaye,M. and Schlessinger,J.|\76: TITLE Cloning of three human tyrosine phosphatases reveals a multigene|\77: family of receptor-linked protein-tyrosine-phosphatases expressed| in brain|\67: JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (18), 7000-7004 (1990)| MEDLINE 90384936|\35:REFERENCE 21 (residues 1 to 1304)|\63: AUTHORS Schraven,B., Samstag,Y., Altevogt,P. and Meuer,S.C.|\62: TITLE Association of CD2 and CD45 on human T lymphocytes|\43: JOURNAL Nature 345 (6270), 71-74 (1990)| MEDLINE 90231464|\35:REFERENCE 22 (residues 1 to 1304)|\39: AUTHORS Pingel,J.T. and Thomas,M.L.|\70: TITLE Evidence that the leukocyte-common antigen is required for|\54: antigen-induced T lymphocyte proliferation|\41: JOURNAL Cell 58 (6), 1055-1065 (1989)| MEDLINE 89376557|\35:REFERENCE 23 (residues 1 to 1304)|\67: AUTHORS Charbonneau,H., Tonks,N.K., Walsh,K.A. and Fischer,E.H.|\75: TITLE The leukocyte common antigen (CD45): a putative receptor-linked|\40: protein tyrosine phosphatase|\67: JOURNAL Proc. Natl. Acad. Sci. U.S.A. 85 (19), 7182-7186 (1988)| MEDLINE 89017162|\35:REFERENCE 24 (residues 1 to 1304)|\72: AUTHORS Streuli,M., Hall,L.R., Saga,Y., Schlossman,S.F. and Saito,H.|\79: TITLE Differential usage of three exons generates at least five different|\58: mRNAs encoding human leukocyte common antigens|\50: JOURNAL J. Exp. Med. 166 (5), 1548-1566 (1987)| MEDLINE 88061067|\35:REFERENCE 25 (residues 1 to 1304)|\68: AUTHORS Ralph,S.J., Thomas,M.L., Morton,C.C. and Trowbridge,I.S.|\76: TITLE Structural variants of human T200 glycoprotein (leukocyte-common| antigen)|\43: JOURNAL EMBO J. 6 (5), 1251-1257 (1987)| MEDLINE 87275816 end obj|Object*|0 end obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp end obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/ end end|1|0|279 obj|Object*|4 obj|Feature obj|DBObj||Source_1|||||0|0| end|269|269|||0|1|279|1|1|1|1|1..279 obj|String*|4|\24:/organism="Homo sapiens"|\21:/db_xref="taxon:9606"|/chromosome="1"|/map="1q31-q32" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Protein_1|||||0|0|\222:protein tyrosine phosphatase, receptor type, c polypeptide; leukocyte-common antigen; T200 glycoprotein; human homolog of severe combined immunodeficiency due to PTPRC deficiency; SCID due to PTPRC deficiency; CD45 antigen end|270|270|||0|1|279|1|1|1|1|1..279 obj|String*|3|\56:/product="protein tyrosine phosphatase, receptor type, C|isoform 1 precursor"|\21:/EC_number="3.1.3.48" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Chain_1|||||0|0| end|203|203|||0|1|279|1|1|1|1|1..279 obj|String*|1|\57:/product="protein tyrosine phosphatase, receptor type, C" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Region_2|||||0|0|PTPc end|266|266|||0|17|277|1|1|1|1|17..277 obj|String*|3|\53:/region_name="Protein tyrosine phosphatase, catalytic|domain"|\25:/db_xref="CDD:smart00194" end|0|| obj|Object*|0 end end end|\279:dilletykrkiadegrlflaefqsiprvfskfpikearkpfnqnknryvdilpydynrvelseingdagsnyinasyidgfkeprkyiaaqgprdetvddfwrmiweqkatvivmvtrceegnrnkcaeywpsmeegtrafgdvvvkinqhkrcpdyiiqklnivnkkekatgrevthiqftswpdhgvpedphlllklrrrvnafsnffsgpivvhcsagvgrtgtyigidamlegleaenkvdvygyvvklrrqrclmvqveaqyilihqalveynq|GenPept| obj|String*|1|NP_002829 end||17-MAY-2003|\21:Homo sapiens (human). obj|String*|0 end|0 obj|String*|0 end|PRT obj|String*|0 end obj|String*|1|Homo sapiens end obj|String*|0 end obj|String*|0 end obj|String*|12|Eukaryota|Metazoa|Chordata|Craniata|Vertebrata|Euteleostomi|Mammalia|Eutheria|Primates|Catarrhini|Hominidae|Homo end obj|Object*|0 end obj|String*|0 end obj|String*|0 end obj|String*|1|\29:REFSEQ: accession NM_002838.2 end obj|String*|21|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC|\52:VNTI URL:vnti:protein/hCD45_D1+%28NP_002829%29+PTPRC end obj|String*|0 end obj|String*|0 end end|F9ABD0 end obj|IxMolX obj|Molecule obj|BioObject obj|DBObj||\26:hDEP1_D1 (NP_002834) PTPRJ|||||302014800|0|\185:protein tyrosine phosphatase, receptor type, J precursor; protein tyrosine phosphatase, receptor type, J polypeptide; human density enhanced phosphatase-1; CD148 antigen [Homo sapiens]. end|2|2| obj|String*|0 end obj|String*|18|\64:REVIEWED REFSEQ: This record has been curated by NCBI staff. The|\45:reference sequence was derived from U10886.1.|\58:On Feb 22, 2002 this sequence version replaced gi:4506315.||\60:Summary: The protein encoded by this gene is a member of the|\63:protein tyrosine phosphatase (PTP) family. PTPs are known to be|\65:signaling molecules that regulate a variety of cellular processes|\58:including cell growth, differentiation, mitotic cycle, and|\61:oncogenic transformation. This PTP possesses an extracellular|\61:region containing five fibronectin type III repeats, a single|\61:transmembrane region, and a single intracytoplasmic catalytic|\60:domain, and thus represents a receptor-type PTP. This PTP is|\66:present in all hematopoietic lineages, and was shown to negatively|\63:regulate T cell receptor signaling possibly through interfering|\63:with the phosphorylation of Phospholipase C Gamma 1 (PLCG1) and|\66:Linker for Activation of T Cells (LAT). This PTP was also found to|\58:dephosphorylate PDGF beta receptor, and may be involved in|\31:UV-induced signal transduction. end obj|String*|61|\35:REFERENCE 1 (residues 1 to 1337)|\76: AUTHORS Ruivenkamp,C.A., van Wezel,T., Zanon,C., Stassen,A.P., Vlcek,C.,|\75: Csikos,T., Klous,A.M., Tripodis,N., Perrakis,A., Boerrigter,L.,|\74: Groot,P.C., Lindeman,J., Mooi,W.J., Meijjer,G.A., Scholten,G.,|\70: Dauwerse,H., Paces,V., van Zandwijk,N., van Ommen,G.J. and|\21: Demant,P.|\74: TITLE Ptprj is a candidate for the mouse colon-cancer susceptibility|\65: locus Scc1 and is frequently deleted in human cancers|\46: JOURNAL Nat. Genet. 31 (3), 295-300 (2002)| MEDLINE 22084388|\71: REMARK GeneRIF: This protein is frequently deleted in human breast| cancers.|\35:REFERENCE 2 (residues 1 to 1337)|\59: AUTHORS Baker,J.E., Majeti,R., Tangye,S.G. and Weiss,A.|\76: TITLE Protein tyrosine phosphatase CD148-mediated inhibition of T-cell|\75: receptor signal transduction is associated with reduced LAT and|\49: phospholipase Cgamma1 phosphorylation|\53: JOURNAL Mol. Cell. Biol. 21 (7), 2393-2403 (2001)| MEDLINE 21160271|\35:REFERENCE 3 (residues 1 to 1337)|\72: AUTHORS Kovalenko,M., Denner,K., Sandstrom,J., Persson,C., Gross,S.,|\57: Jandt,E., Vilella,R., Bohmer,F. and Ostman,A.|\75: TITLE Site-selective dephosphorylation of the platelet-derived growth|\70: factor beta-receptor by the receptor-like protein-tyrosine|\29: phosphatase DEP-1|\55: JOURNAL J. Biol. Chem. 275 (21), 16219-16226 (2000)| MEDLINE 20283660|\35:REFERENCE 4 (residues 1 to 1337)|\68: AUTHORS Gross,S., Knebel,A., Tenev,T., Neininger,A., Gaestel,M.,|\39: Herrlich,P. and Bohmer,F.D.|\73: TITLE Inactivation of protein-tyrosine phosphatases as mechanism of|\42: UV-induced signal transduction|\55: JOURNAL J. Biol. Chem. 274 (37), 26378-26386 (1999)| MEDLINE 99403084|\35:REFERENCE 5 (residues 1 to 1337)|\70: AUTHORS Tangye,S.G., Phillips,J.H., Lanier,L.L., de Vries,J.E. and|\21: Aversa,G.|\79: TITLE CD148: a receptor-type protein tyrosine phosphatase involved in the|\49: regulation of human T cell activation|\49: JOURNAL J. Immunol. 161 (7), 3249-3255 (1998)| MEDLINE 98430639|\35:REFERENCE 6 (residues 1 to 1337)|\73: AUTHORS de la Fuente-Garcia,M.A., Nicolas,J.M., Freed,J.H., Palou,E.,|\57: Thomas,A.P., Vilella,R., Vives,J. and Gaya,A.|\75: TITLE CD148 is a membrane protein tyrosine phosphatase present in all|\76: hematopoietic lineages and is involved in signal transduction on|\23: lymphocytes|\42: JOURNAL Blood 91 (8), 2800-2809 (1998)| MEDLINE 98200586|\35:REFERENCE 7 (residues 1 to 1337)|\68: AUTHORS Honda,H., Inazawa,J., Nishida,J., Yazaki,Y. and Hirai,H.|\77: TITLE Molecular cloning, characterization, and chromosomal localization|\61: of a novel protein-tyrosine phosphatase, HPTP eta|\43: JOURNAL Blood 84 (12), 4186-4194 (1994)| MEDLINE 95086212|\35:REFERENCE 8 (residues 1 to 1337)|\45: AUTHORS Ostman,A., Yang,Q. and Tonks,N.K.|\78: TITLE Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase,|\52: is enhanced with increasing cell density|\67: JOURNAL Proc. Natl. Acad. Sci. U.S.A. 91 (21), 9680-9684 (1994)| MEDLINE 95024024 end obj|Object*|0 end obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp end obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/ end end|1|0|277 obj|Object*|4 obj|Feature obj|DBObj||Source_1|||||0|0| end|269|269|||0|1|277|1|1|1|1|1..277 obj|String*|4|\24:/organism="Homo sapiens"|\21:/db_xref="taxon:9606"|/chromosome="11"|/map="11p11.2" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Protein_1|||||0|0|\111:protein tyrosine phosphatase, receptor type, J polypeptide; human density enhanced phosphatase-1; CD148 antigen end|270|270|||0|1|277|1|1|1|1|1..277 obj|String*|3|\56:/product="protein tyrosine phosphatase, receptor type, J|precursor"|\21:/EC_number="3.1.3.48" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Chain_1|||||0|0| end|203|203|||0|1|277|1|1|1|1|1..277 obj|String*|1|\57:/product="protein tyrosine phosphatase, receptor type, J" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Region_1|||||0|0|PTPc end|266|266|||0|17|277|1|1|1|1|17..277 obj|String*|3|\53:/region_name="Protein tyrosine phosphatase, catalytic|domain"|\25:/db_xref="CDD:smart00194" end|0|| obj|Object*|0 end end end|\277:enfeayfkkqqadsncgfaeeyedlklvgisqpkyaaelaenrgknrynnvlpydisrvklsvqthstddyinanympgyhskkdfiatqgplpntlkdfwrmvweknvyaiimltkcveqgrtkceeywpskqaqdygditvamtseivlpewtirdftvkniqtseshplrqfhftswpdhgvpdttdllinfrylvrdymkqsppespilvhcsagvgrtgtfiaidrliyqienentvdvygivydlrmhrplmvqtedqyvflnqcvldivr|GenPept| obj|String*|1|NP_002834 end||17-MAY-2003|\21:Homo sapiens (human). obj|String*|0 end|0 obj|String*|0 end|PRT obj|String*|0 end obj|String*|1|Homo sapiens end obj|String*|0 end obj|String*|0 end obj|String*|12|Eukaryota|Metazoa|Chordata|Craniata|Vertebrata|Euteleostomi|Mammalia|Eutheria|Primates|Catarrhini|Hominidae|Homo end obj|Object*|0 end obj|String*|0 end obj|String*|0 end obj|String*|1|\29:REFSEQ: accession NM_002843.2 end obj|String*|21|\52:VNTI URL:vnti:protein/hDEP1_D1+%28NP_002834%29+PTPRJ|\52:VNTI URL:vnti:protein/hDEP1_D1+%28NP_002834%29+PTPRJ|\52:VNTI URL:vnti:protein/hDEP1_D1+%28NP_002834%29+PTPRJ|\52:VNTI URL:vnti:protein/hDEP1_D1+%28NP_002834%29+PTPRJ|\52:VNTI URL:vnti:protein/hDEP1_D1+%28NP_002834%29+PTPRJ|\52:VNTI URL:vnti:protein/hDEP1_D1+%28NP_002834%29+PTPRJ|\52:VNTI URL:vnti:protein/hDEP1_D1+%28NP_002834%29+PTPRJ|\52:VNTI URL:vnti:protein/hDEP1_D1+%28NP_002834%29+PTPRJ|\52:VNTI URL:vnti:protein/hDEP1_D1+%28NP_002834%29+PTPRJ|\52:VNTI URL:vnti:protein/hDEP1_D1+%28NP_002834%29+PTPRJ|\52:VNTI URL:vnti:protein/hDEP1_D1+%28NP_002834%29+PTPRJ|\52:VNTI URL:vnti:protein/hDEP1_D1+%28NP_002834%29+PTPRJ|\52:VNTI URL:vnti:protein/hDEP1_D1+%28NP_002834%29+PTPRJ|\52:VNTI URL:vnti:protein/hDEP1_D1+%28NP_002834%29+PTPRJ|\52:VNTI URL:vnti:protein/hDEP1_D1+%28NP_002834%29+PTPRJ|\52:VNTI URL:vnti:protein/hDEP1_D1+%28NP_002834%29+PTPRJ|\52:VNTI URL:vnti:protein/hDEP1_D1+%28NP_002834%29+PTPRJ|\52:VNTI URL:vnti:protein/hDEP1_D1+%28NP_002834%29+PTPRJ|\52:VNTI URL:vnti:protein/hDEP1_D1+%28NP_002834%29+PTPRJ|\52:VNTI URL:vnti:protein/hDEP1_D1+%28NP_002834%29+PTPRJ|\52:VNTI URL:vnti:protein/hDEP1_D1+%28NP_002834%29+PTPRJ end obj|String*|0 end obj|String*|0 end end|FA24E8 end obj|IxMolX obj|Molecule obj|BioObject obj|DBObj||\28:hGLEPP1_D1 (NP_109592) PTPRO|||||302014800|0|\201:receptor-type protein tyrosine phosphatase O isoform a precursor; glomerular epithelial protein-1; protein tyrosine phosphatase PTP-U2; phosphotyrosine phosphatase U2; PTPase U2; PTPROt [Homo sapiens]. end|2|2| obj|String*|0 end obj|String*|17|\64:REVIEWED REFSEQ: This record has been curated by NCBI staff. The|\58:reference sequence was derived from Z48541.1 and U20489.1.||\59:Summary: This gene encodes a receptor-type protein tyrosine|\67:phosphatase containing a single intracellular catalytic domain with|\63:a characteristic signature motif. The gene product, which has a|\62:transmembrane domain, is an integral membrane protein. Several|\63:alternatively spliced transcript variants, some of which encode|\61:different isoforms of the protein, have been described. These|\44:variants exhibit tissue-specific expression.||\64:Transcript Variant: This variant (1) encodes the longest isoform|\64:(a) known to date. The encoded protein has a large extracellular|\65:domain containing 8 repeats of a fibronectin type III-like motif.|\67:This variant is expressed in the glomerulus of kidney and in brain.|\65:In kidney, it may play a role in regulating glomerular epithelial|\42:cell (podocyte) structure and/or function. end obj|String*|22|\35:REFERENCE 1 (residues 1 to 1216)|\77: AUTHORS Aguiar,R.C., Yakushijin,Y., Kharbanda,S., Tiwari,S., Freeman,G.J.|\26: and Shipp,M.A.|\74: TITLE PTPROt: an alternatively spliced and developmentally regulated|\61: B-lymphoid phosphatase that promotes G0/G1 arrest|\42: JOURNAL Blood 94 (7), 2403-2413 (1999)| MEDLINE 99428326|\35:REFERENCE 2 (residues 1 to 1216)|\59: AUTHORS Seimiya,H., Sawabe,T., Inazawa,J. and Tsuruo,T.|\76: TITLE Cloning, expression and chromosomal localization of a novel gene|\72: for protein tyrosine phosphatase (PTP-U2) induced by various|\43: differentiation-inducing agents|\45: JOURNAL Oncogene 10 (9), 1731-1738 (1995)| MEDLINE 95273089|\35:REFERENCE 3 (residues 1 to 1216)|\78: AUTHORS Wiggins,R.C., Wiggins,J.E., Goyal,M., Wharram,B.L. and Thomas,P.E.|\72: TITLE Molecular cloning of cDNAs encoding human GLEPP1, a membrane|\72: protein tyrosine phosphatase: characterization of the GLEPP1|\77: protein distribution in human kidney and assignment of the GLEPP1|\46: gene to human chromosome 12p12-p13|\43: JOURNAL Genomics 27 (1), 174-181 (1995)| MEDLINE 95394455 end obj|Object*|0 end obj|CreatorData|||||\28:jannik@noergaardandersen.com|||JNA||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp end obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/ end end|1|0|277 obj|Object*|2 obj|Feature obj|DBObj||Region_2|||||0|0|PTPc end|266|266|||0|17|272|1|1|1|1|17..272 obj|String*|3|\53:/region_name="Protein tyrosine phosphatase, catalytic|domain"|\25:/db_xref="CDD:smart00194" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Dom_Misc_3|||||0|0| end|1000|1000|||0|214|224|1|1|1|1|214..224 obj|String*|1|\47:/region_name="catalytic domain signature motif" end|0|| obj|Object*|0 end end end|\277:ddfdayikdmakdsdykfslqfeelkligldiphfaadlplnrcknrytnilpydfsrvrlvsmneeegadyinanyipgynspqeyiatqgplpetrndfwkmvlqqksqiivmltqcnekrrvkcdhywpfteepiaygditvemiseeeqddwacrhfrinyademqdvmhfnytawpdhgvptanaaesilqfvhmvrqqatkskgpmiihcsagvgrtgtfialdrllqhirdhefvdilglvsemrsyrmsmvqteeqyifihqcvqlmwm|GenPept| obj|String*|1|NP_109592 end||27-JUN-2003|\21:Homo sapiens (human). obj|String*|0 end|0 obj|String*|0 end|PRT obj|String*|0 end obj|String*|1|Homo sapiens end obj|String*|0 end obj|String*|0 end obj|String*|12|Eukaryota|Metazoa|Chordata|Craniata|Vertebrata|Euteleostomi|Mammalia|Eutheria|Primates|Catarrhini|Hominidae|Homo end obj|Object*|0 end obj|String*|0 end obj|String*|0 end obj|String*|1|\29:REFSEQ: accession NM_030667.1 end obj|String*|21|\54:VNTI URL:vnti:protein/hGLEPP1_D1+%28NP_109592%29+PTPRO|\54:VNTI URL:vnti:protein/hGLEPP1_D1+%28NP_109592%29+PTPRO|\54:VNTI URL:vnti:protein/hGLEPP1_D1+%28NP_109592%29+PTPRO|\54:VNTI URL:vnti:protein/hGLEPP1_D1+%28NP_109592%29+PTPRO|\54:VNTI URL:vnti:protein/hGLEPP1_D1+%28NP_109592%29+PTPRO|\54:VNTI URL:vnti:protein/hGLEPP1_D1+%28NP_109592%29+PTPRO|\54:VNTI URL:vnti:protein/hGLEPP1_D1+%28NP_109592%29+PTPRO|\54:VNTI URL:vnti:protein/hGLEPP1_D1+%28NP_109592%29+PTPRO|\54:VNTI URL:vnti:protein/hGLEPP1_D1+%28NP_109592%29+PTPRO|\54:VNTI URL:vnti:protein/hGLEPP1_D1+%28NP_109592%29+PTPRO|\54:VNTI URL:vnti:protein/hGLEPP1_D1+%28NP_109592%29+PTPRO|\54:VNTI URL:vnti:protein/hGLEPP1_D1+%28NP_109592%29+PTPRO|\54:VNTI URL:vnti:protein/hGLEPP1_D1+%28NP_109592%29+PTPRO|\54:VNTI URL:vnti:protein/hGLEPP1_D1+%28NP_109592%29+PTPRO|\54:VNTI URL:vnti:protein/hGLEPP1_D1+%28NP_109592%29+PTPRO|\54:VNTI URL:vnti:protein/hGLEPP1_D1+%28NP_109592%29+PTPRO|\54:VNTI URL:vnti:protein/hGLEPP1_D1+%28NP_109592%29+PTPRO|\54:VNTI URL:vnti:protein/hGLEPP1_D1+%28NP_109592%29+PTPRO|\54:VNTI URL:vnti:protein/hGLEPP1_D1+%28NP_109592%29+PTPRO|\54:VNTI URL:vnti:protein/hGLEPP1_D1+%28NP_109592%29+PTPRO|\54:VNTI URL:vnti:protein/hGLEPP1_D1+%28NP_109592%29+PTPRO end obj|String*|0 end obj|String*|0 end end|FA6D50 end obj|IxMolX obj|Molecule obj|BioObject obj|DBObj||\28:hHDPTP_D1 (NP_056281) PTPN23|||||302014800|0|\107:protein tyrosine phosphatase, non-receptor type 23; His-domain protein tyrosine phosphatase [Homo sapiens]. end|2|2| obj|String*|0 end obj|String*|3|\62:PREDICTED REFSEQ: The mRNA record is supported by experimental|\66:evidence; however, the coding sequence is predicted. The reference|\37:sequence was derived from AF290614.1. end obj|String*|12|\35:REFERENCE 1 (residues 1 to 1636)|\79: AUTHORS Qu,X., Zhai,Y., Wei,H., Zhang,C., Xing,G., Lu,C., Wang,M. and He,F.|\76: TITLE Cloning, chromosomal assignment and tissue expression of a novel|\62: human protein tyrosine phosphatase (PTP-TD14) gene|\38: JOURNAL I Chuan 23 (6), 1-9 (2001)|\35:REFERENCE 2 (residues 1 to 1636)|\71: AUTHORS Toyooka,S., Ouchida,M., Jitsumori,Y., Tsukuda,K., Sakai,A.,|\50: Nakamura,A., Shimizu,N. and Shimizu,K.|\70: TITLE HD-PTP: A novel protein tyrosine phosphatase gene on human|\29: chromosome 3p21.3|\66: JOURNAL Biochem. Biophys. Res. Commun. 278 (3), 671-678 (2000)| MEDLINE 20549011 end obj|Object*|0 end obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp end obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/ end end|1|0|286 obj|Object*|3 obj|Feature obj|DBObj||Source_1|||||0|0| end|269|269|||0|1|286|1|1|1|1|1..286 obj|String*|7|\24:/organism="Homo sapiens"|\21:/db_xref="taxon:9606"|/chromosome="3"|/map="3p21.3"|/clone="F2896"|/tissue_type="liver"|/dev_stage="fetus" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Protein_1|||||0|0|\39:His-domain protein tyrosine phosphatase end|270|270|||0|1|286|1|1|1|1|1..286 obj|String*|2|\57:/product="protein tyrosine phosphatase, non-receptor type|23" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Region_2|||||0|0|PTPc end|266|266|||0|23|286|1|1|1|1|23..286 obj|String*|3|\53:/region_name="Protein tyrosine phosphatase, catalytic|domain"|\25:/db_xref="CDD:smart00194" end|0|| obj|Object*|0 end end end|\286:erlrqlqqeleafrgqlgdvgaldtvwrelqdaqehdargrsiaiarcyslknrhqdvmpydsnrvvlrsgkddyinascveglspycpplvatqaplpgtaadfwlmvheqkvsvivmlvseaemekqkvaryfptergqpmvhgalslalssvrstethvervlslqfrdqslkrslvhlhfptwpelglpdspsnllrfiqevhahylhqrplhtpiivhcssgvgrtgafallyaavqeveagngipelpqlvrrmrqqrkhmlqeklhlrfcyeavvrhve|GenPept| obj|String*|1|NP_056281 end||17-MAY-2003|\21:Homo sapiens (human). obj|String*|0 end|0 obj|String*|0 end|PRT obj|String*|0 end obj|String*|1|Homo sapiens end obj|String*|0 end obj|String*|0 end obj|String*|12|Eukaryota|Metazoa|Chordata|Craniata|Vertebrata|Euteleostomi|Mammalia|Eutheria|Primates|Catarrhini|Hominidae|Homo end obj|Object*|0 end obj|String*|0 end obj|String*|0 end obj|String*|1|\29:REFSEQ: accession NM_015466.1 end obj|String*|21|\54:VNTI URL:vnti:protein/hHDPTP_D1+%28NP_056281%29+PTPN23|\54:VNTI URL:vnti:protein/hHDPTP_D1+%28NP_056281%29+PTPN23|\54:VNTI URL:vnti:protein/hHDPTP_D1+%28NP_056281%29+PTPN23|\54:VNTI URL:vnti:protein/hHDPTP_D1+%28NP_056281%29+PTPN23|\54:VNTI URL:vnti:protein/hHDPTP_D1+%28NP_056281%29+PTPN23|\54:VNTI URL:vnti:protein/hHDPTP_D1+%28NP_056281%29+PTPN23|\54:VNTI URL:vnti:protein/hHDPTP_D1+%28NP_056281%29+PTPN23|\54:VNTI URL:vnti:protein/hHDPTP_D1+%28NP_056281%29+PTPN23|\54:VNTI URL:vnti:protein/hHDPTP_D1+%28NP_056281%29+PTPN23|\54:VNTI URL:vnti:protein/hHDPTP_D1+%28NP_056281%29+PTPN23|\54:VNTI URL:vnti:protein/hHDPTP_D1+%28NP_056281%29+PTPN23|\54:VNTI URL:vnti:protein/hHDPTP_D1+%28NP_056281%29+PTPN23|\54:VNTI URL:vnti:protein/hHDPTP_D1+%28NP_056281%29+PTPN23|\54:VNTI URL:vnti:protein/hHDPTP_D1+%28NP_056281%29+PTPN23|\54:VNTI URL:vnti:protein/hHDPTP_D1+%28NP_056281%29+PTPN23|\54:VNTI URL:vnti:protein/hHDPTP_D1+%28NP_056281%29+PTPN23|\54:VNTI URL:vnti:protein/hHDPTP_D1+%28NP_056281%29+PTPN23|\54:VNTI URL:vnti:protein/hHDPTP_D1+%28NP_056281%29+PTPN23|\54:VNTI URL:vnti:protein/hHDPTP_D1+%28NP_056281%29+PTPN23|\54:VNTI URL:vnti:protein/hHDPTP_D1+%28NP_056281%29+PTPN23|\54:VNTI URL:vnti:protein/hHDPTP_D1+%28NP_056281%29+PTPN23 end obj|String*|0 end obj|String*|0 end end|FA8D20 end obj|IxMolX obj|Molecule obj|BioObject obj|DBObj||\27:hHePTP_D1 (NP_002823) PTPN7|||||302014800|0|\182:protein tyrosine phosphatase, non-receptor type 7 isoform 1; protein-tyrosine phoshatase, nonreceptor-type, stress induced; hematopoietic protein-tyrosine phosphatase [Homo sapiens]. end|2|2| obj|String*|0 end obj|String*|23|\64:REVIEWED REFSEQ: This record has been curated by NCBI staff. The|\59:reference sequence was derived from BC001746.1, BG340453.1,|\22:D11327.1 and M64322.1.|\58:On Jan 25, 2002 this sequence version replaced gi:4506299.||\60:Summary: The protein encoded by this gene is a member of the|\63:protein tyrosine phosphatase (PTP) family. PTPs are known to be|\65:signaling molecules that regulate a variety of cellular processes|\58:including cell growth, differentiation, mitotic cycle, and|\66:oncogenic transformation. This gene is preferentially expressed in|\66:a variety of hematopoietic cells, and is an early response gene in|\64:lymphokine stimulated cells. The noncatalytic N-terminus of this|\61:PTP can interact with MAP kinases and suppress the MAP kinase|\66:activities. This PTP was shown to be involved in the regulation of|\61:T cell antigen receptor (TCR) signaling, which was thought to|\63:function through dephosphorylating the molecules related to MAP|\66:kinase pathway. Three alternatively spliced transcript variants of|\60:this gene, which encode two distinct isoforms, are reported.||\60:Transcript Variant: This variant (1) contains a different 5'|\66:region, which includes a part of the coding sequence when compared|\58:to variant 2. It thus encodes a protein that has a shorter|\37:N-terminus, as compared to isoform 2. end obj|String*|47|\34:REFERENCE 1 (residues 1 to 360)|\76: AUTHORS Oh-hora,M., Ogata,M., Mori,Y., Adachi,M., Imai,K., Kosugi,A. and|\22: Hamaoka,T.|\74: TITLE Direct suppression of TCR-mediated activation of extracellular|\78: signal-regulated kinase by leukocyte protein tyrosine phosphatase,|\43: a tyrosine-specific phosphatase|\49: JOURNAL J. Immunol. 163 (3), 1282-1288 (1999)| MEDLINE 99343735|\34:REFERENCE 2 (residues 1 to 360)|\76: AUTHORS Saxena,M., Williams,S., Brockdorff,J., Gilman,J. and Mustelin,T.|\71: TITLE Inhibition of T cell signaling by mitogen-activated protein|\70: kinase-targeted hematopoietic tyrosine phosphatase (HePTP)|\55: JOURNAL J. Biol. Chem. 274 (17), 11693-11700 (1999)| MEDLINE 99223488|\34:REFERENCE 3 (residues 1 to 360)|\61: AUTHORS Saxena,M., Williams,S., Gilman,J. and Mustelin,T.|\78: TITLE Negative regulation of T cell antigen receptor signal transduction|\57: by hematopoietic tyrosine phosphatase (HePTP)|\55: JOURNAL J. Biol. Chem. 273 (25), 15340-15344 (1998)| MEDLINE 98288260|\34:REFERENCE 4 (residues 1 to 360)|\71: AUTHORS Swieter,M., Berenstein,E.H., Swaim,W.D. and Siraganian,R.P.|\77: TITLE Aggregation of IgE receptors in rat basophilic leukemia 2H3 cells|\78: induces tyrosine phosphorylation of the cytosolic protein-tyrosine|\29: phosphatase HePTP|\55: JOURNAL J. Biol. Chem. 270 (37), 21902-21906 (1995)| MEDLINE 95394959|\34:REFERENCE 5 (residues 1 to 360)|\75: AUTHORS Adachi,M., Sekiya,M., Isobe,M., Kumura,Y., Ogita,Z., Hinoda,Y.,|\32: Imai,K. and Yachi,A.|\64: TITLE Molecular cloning and chromosomal mapping of a human|\47: protein-tyrosine phosphatase LC-PTP|\68: JOURNAL Biochem. Biophys. Res. Commun. 186 (3), 1607-1615 (1992)| MEDLINE 92378634|\34:REFERENCE 6 (residues 1 to 360)|\78: AUTHORS Adachi,M., Sekiya,M., Arimura,Y., Takekawa,M., Itoh,F., Hinoda,Y.,|\32: Imai,K. and Yachi,A.|\72: TITLE Protein-tyrosine phosphatase expression in pre-B cell NALM-6|\46: JOURNAL Cancer Res. 52 (3), 737-740 (1992)| MEDLINE 92119637|\22:REFERENCE 7 (sites)|\78: AUTHORS Zanke,B., Suzuki,H., Kishihara,K., Mizzen,L., Minden,M., Pawson,A.|\24: and Mak,T.W.|\77: TITLE Cloning and expression of an inducible lymphoid-specific, protein|\43: tyrosine phosphatase (HePTPase)|\51: JOURNAL Eur. J. Immunol. 22 (1), 235-239 (1992)| MEDLINE 92111631 end obj|Object*|0 end obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp end obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/ end end|1|0|273 obj|Object*|3 obj|Feature obj|DBObj||Source_1|||||0|0| end|269|269|||0|1|273|1|1|1|1|1..273 obj|String*|4|\24:/organism="Homo sapiens"|\21:/db_xref="taxon:9606"|/chromosome="1"|/map="1q32.1" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Protein_1|||||0|0|\105:protein-tyrosine phoshatase, nonreceptor-type, stress induced; hematopoietic protein-tyrosine phosphatase end|270|270|||0|1|273|1|1|1|1|1..273 obj|String*|2|\57:/product="protein tyrosine phosphatase, non-receptor type|7 isoform 1" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Region_1|||||0|0|PTPc end|266|266|||0|17|271|1|1|1|1|17..271 obj|String*|3|\53:/region_name="Protein tyrosine phosphatase, catalytic|domain"|\25:/db_xref="CDD:smart00194" end|0|| obj|Object*|0 end end end|\273:hpltrwalqrqppspkqleeeflkipsnfvspedldipghaskdryktilpnpqsrvclgraqsqedgdyinanyirgydgkekvyiatqgpmpntvsdfwemvwqeevslivmltqlregkekcvhywpteeetygpfqiriqdmkecpeytvrqltiqyqeerrsvkhilfsawpdhqtpesagpllrlvaeveespetaahpgpivvhcsagigrtgcfiatrigcqqlkargevdilgivcqlrldrggmiqtaeqyqflhhtlalyag|GenPept| obj|String*|1|NP_002823 end||17-MAY-2003|\21:Homo sapiens (human). obj|String*|0 end|0 obj|String*|0 end|PRT obj|String*|0 end obj|String*|1|Homo sapiens end obj|String*|0 end obj|String*|0 end obj|String*|12|Eukaryota|Metazoa|Chordata|Craniata|Vertebrata|Euteleostomi|Mammalia|Eutheria|Primates|Catarrhini|Hominidae|Homo end obj|Object*|0 end obj|String*|0 end obj|String*|0 end obj|String*|1|\29:REFSEQ: accession NM_002832.2 end obj|String*|21|\53:VNTI URL:vnti:protein/hHePTP_D1+%28NP_002823%29+PTPN7|\53:VNTI URL:vnti:protein/hHePTP_D1+%28NP_002823%29+PTPN7|\53:VNTI URL:vnti:protein/hHePTP_D1+%28NP_002823%29+PTPN7|\53:VNTI URL:vnti:protein/hHePTP_D1+%28NP_002823%29+PTPN7|\53:VNTI URL:vnti:protein/hHePTP_D1+%28NP_002823%29+PTPN7|\53:VNTI URL:vnti:protein/hHePTP_D1+%28NP_002823%29+PTPN7|\53:VNTI URL:vnti:protein/hHePTP_D1+%28NP_002823%29+PTPN7|\53:VNTI URL:vnti:protein/hHePTP_D1+%28NP_002823%29+PTPN7|\53:VNTI URL:vnti:protein/hHePTP_D1+%28NP_002823%29+PTPN7|\53:VNTI URL:vnti:protein/hHePTP_D1+%28NP_002823%29+PTPN7|\53:VNTI URL:vnti:protein/hHePTP_D1+%28NP_002823%29+PTPN7|\53:VNTI URL:vnti:protein/hHePTP_D1+%28NP_002823%29+PTPN7|\53:VNTI URL:vnti:protein/hHePTP_D1+%28NP_002823%29+PTPN7|\53:VNTI URL:vnti:protein/hHePTP_D1+%28NP_002823%29+PTPN7|\53:VNTI URL:vnti:protein/hHePTP_D1+%28NP_002823%29+PTPN7|\53:VNTI URL:vnti:protein/hHePTP_D1+%28NP_002823%29+PTPN7|\53:VNTI URL:vnti:protein/hHePTP_D1+%28NP_002823%29+PTPN7|\53:VNTI URL:vnti:protein/hHePTP_D1+%28NP_002823%29+PTPN7|\53:VNTI URL:vnti:protein/hHePTP_D1+%28NP_002823%29+PTPN7|\53:VNTI URL:vnti:protein/hHePTP_D1+%28NP_002823%29+PTPN7|\53:VNTI URL:vnti:protein/hHePTP_D1+%28NP_002823%29+PTPN7 end obj|String*|0 end obj|String*|0 end end|FAAD10 end obj|IxMolX obj|Molecule obj|BioObject obj|DBObj||\25:hIA2_D1 (NP_002837) PTPRN|||||302014800|0|\191:protein tyrosine phosphatase, receptor type, N precursor; islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N precursor [Homo sapiens]. end|2|2| obj|String*|0 end obj|String*|14|\64:REVIEWED REFSEQ: This record has been curated by NCBI staff. The|\60:reference sequence was derived from L18983.1, AF042285.4 and|BC007713.1.||\60:Summary: The protein encoded by this gene is a member of the|\63:protein tyrosine phosphatase (PTP) family. PTPs are known to be|\65:signaling molecules that regulate a variety of cellular processes|\58:including cell growth, differentiation, mitotic cycle, and|\61:oncogenic transformation. This PTP possesses an extracellular|\61:region, a single transmembrane region, and a single catalytic|\67:domain, and thus represents a receptor-type PTP. This PTP was found|\60:to be an autoantigen that is reactive with insulin-dependent|\66:diabetes mellitus (IDDM) patient sera, and thus may be a potential|\44:target of autoimmunity in diabetes mellitus. end obj|String*|59|\34:REFERENCE 1 (residues 1 to 979)|\60: AUTHORS Sanjeevi,C.B., Das,A.K. and Shtauvere-Brameus,A.|\75: TITLE BCG vaccination and GAD65 and IA-2 autoantibodies in autoimmune|\38: diabetes in southern India|\53: JOURNAL Ann. N. Y. Acad. Sci. 958, 293-296 (2002)| MEDLINE 22015049|\73: REMARK GeneRIF: BCG vaccination and GAD65 and IA-2 autoantibodies in|\50: autoimmune diabetes in southern India.|\34:REFERENCE 2 (residues 1 to 979)|\76: AUTHORS Kawasaki,E., Yamaguchi,H., Hattori,H., Egashira,T. and Eguchi,K.|\78: TITLE Autoantibodies to IA-2 in type 1 diabetes: measurements with a new|\45: enzyme-linked immunosorbent assay|\53: JOURNAL Ann. N. Y. Acad. Sci. 958, 241-246 (2002)| MEDLINE 22015037|\76: REMARK GeneRIF: Autoantibodies to IA-2 in type 1 diabetes: measurements|\57: with a new enzyme-linked immunosorbent assay.|\34:REFERENCE 3 (residues 1 to 979)|\71: AUTHORS Miao,D., Yu,L., Tiberti,C., Cuthbertson,D.D., Rewers,M., di|\50: Mario,U., Eisenbarth,G.S. and Dotta,F.|\75: TITLE ICA512(IA-2) epitope specific assays distinguish transient from|\46: diabetes associated autoantibodies|\48: JOURNAL J. Autoimmun. 18 (2), 191-196 (2002)| MEDLINE 21906940|\79: REMARK GeneRIF: ICA512(IA-2) epitope specific assays distinguish transient|\52: from diabetes associated autoantibodies.|\34:REFERENCE 4 (residues 1 to 979)|\42: AUTHORS Mikulecky,M. and Michalkova,D.|\73: TITLE Secular and seasonal cycling of IA2-ab autoantibody in Slovak|\29: diabetic children|\62: JOURNAL Biomed. Pharmacother. 55 Suppl 1, 106S-109S (2001)| MEDLINE 21630621|\34:REFERENCE 5 (residues 1 to 979)|\75: AUTHORS Cui,L., Yu,W.P., DeAizpurua,H.J., Schmidli,R.S. and Pallen,C.J.|\70: TITLE Cloning and characterization of islet cell antigen-related|\77: protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and|\53: autoantigen in insulin-dependent diabetes|\55: JOURNAL J. Biol. Chem. 271 (40), 24817-24823 (1996)| MEDLINE 96394649|\34:REFERENCE 6 (residues 1 to 979)|\71: AUTHORS van den Maagdenberg,A.M., Olde Weghuis,D., Rijss,J., van de|\78: Wetering,R.A., Wieringa,B., Geurts van Kessel,A. and Hendriks,W.J.|\75: TITLE Assignment of the human gene for receptor-type protein tyrosine|\76: phosphatase IA-2 (PTPRN) to chromosome region 2q35 --> q36.1 and|\58: identification of an intragenic genetic marker|\59: JOURNAL Cytogenet. Cell Genet. 73 (1-2), 145-148 (1996)| MEDLINE 96244610|\34:REFERENCE 7 (residues 1 to 979)|\53: AUTHORS Lan,M.S., Lu,J., Goto,Y. and Notkins,A.L.|\75: TITLE Molecular cloning and identification of a receptor-type protein|\61: tyrosine phosphatase, IA-2, from human insulinoma|\49: JOURNAL DNA Cell Biol. 13 (5), 505-514 (1994)| MEDLINE 94296553|\34:REFERENCE 8 (residues 1 to 979)|\75: AUTHORS Rabin,D.U., Pleasic,S.M., Shapiro,J.A., Yoo-Warren,H., Oles,J.,|\51: Hicks,J.M., Goldstein,D.E. and Rae,P.M.|\75: TITLE Islet cell antigen 512 is a diabetes-specific islet autoantigen|\52: related to protein tyrosine phosphatases|\49: JOURNAL J. Immunol. 152 (6), 3183-3188 (1994)| MEDLINE 94194080 end obj|Object*|0 end obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp end obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/ end end|1|0|279 obj|Object*|4 obj|Feature obj|DBObj||Source_1|||||0|0| end|269|269|||0|1|279|1|1|1|1|1..279 obj|String*|4|\24:/organism="Homo sapiens"|\21:/db_xref="taxon:9606"|/chromosome="2"|/map="2q35-q36.1" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Protein_1|||||0|0|\117:islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N precursor end|270|270|||0|1|279|1|1|1|1|1..279 obj|String*|3|\56:/product="protein tyrosine phosphatase, receptor type, N|precursor"|\21:/EC_number="3.1.3.48" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Chain_1|||||0|0| end|203|203|||0|1|279|1|1|1|1|1..279 obj|String*|1|\57:/product="protein tyrosine phosphatase, receptor type, N" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Region_1|||||0|0|PTPc end|266|266|||0|17|278|1|1|1|1|17..278 obj|String*|3|\53:/region_name="Protein tyrosine phosphatase, catalytic|domain"|\25:/db_xref="CDD:smart00194" end|0|| obj|Object*|0 end end end|\279:hmilaymedhlrnrdrlakewqalcayqaepntcataqgegnikknrhpdflpydhariklkvesspsrsdyinaspiiehdprmpayiatqgplshtiadfwqmvwesgctvivmltplvedgvkqcdrywpdegaslyhvyevnlvsehiwcedflvrsfylknvqtqetrtltqfhflswpaegtpastrplldfrrkvnkcyrgrscpiivhcsdgagrtgtyilidmvlnrmakgvkeidiaatlehvrdqrpglvrskdqfefaltavaeevn|GenPept| obj|String*|1|NP_002837 end||17-MAY-2003|\21:Homo sapiens (human). obj|String*|0 end|0 obj|String*|0 end|PRT obj|String*|0 end obj|String*|1|Homo sapiens end obj|String*|0 end obj|String*|0 end obj|String*|12|Eukaryota|Metazoa|Chordata|Craniata|Vertebrata|Euteleostomi|Mammalia|Eutheria|Primates|Catarrhini|Hominidae|Homo end obj|Object*|0 end obj|String*|0 end obj|String*|0 end obj|String*|1|\29:REFSEQ: accession NM_002846.2 end obj|String*|21|\51:VNTI URL:vnti:protein/hIA2_D1+%28NP_002837%29+PTPRN|\51:VNTI URL:vnti:protein/hIA2_D1+%28NP_002837%29+PTPRN|\51:VNTI URL:vnti:protein/hIA2_D1+%28NP_002837%29+PTPRN|\51:VNTI URL:vnti:protein/hIA2_D1+%28NP_002837%29+PTPRN|\51:VNTI URL:vnti:protein/hIA2_D1+%28NP_002837%29+PTPRN|\51:VNTI URL:vnti:protein/hIA2_D1+%28NP_002837%29+PTPRN|\51:VNTI URL:vnti:protein/hIA2_D1+%28NP_002837%29+PTPRN|\51:VNTI URL:vnti:protein/hIA2_D1+%28NP_002837%29+PTPRN|\51:VNTI URL:vnti:protein/hIA2_D1+%28NP_002837%29+PTPRN|\51:VNTI URL:vnti:protein/hIA2_D1+%28NP_002837%29+PTPRN|\51:VNTI URL:vnti:protein/hIA2_D1+%28NP_002837%29+PTPRN|\51:VNTI URL:vnti:protein/hIA2_D1+%28NP_002837%29+PTPRN|\51:VNTI URL:vnti:protein/hIA2_D1+%28NP_002837%29+PTPRN|\51:VNTI URL:vnti:protein/hIA2_D1+%28NP_002837%29+PTPRN|\51:VNTI URL:vnti:protein/hIA2_D1+%28NP_002837%29+PTPRN|\51:VNTI URL:vnti:protein/hIA2_D1+%28NP_002837%29+PTPRN|\51:VNTI URL:vnti:protein/hIA2_D1+%28NP_002837%29+PTPRN|\51:VNTI URL:vnti:protein/hIA2_D1+%28NP_002837%29+PTPRN|\51:VNTI URL:vnti:protein/hIA2_D1+%28NP_002837%29+PTPRN|\51:VNTI URL:vnti:protein/hIA2_D1+%28NP_002837%29+PTPRN|\51:VNTI URL:vnti:protein/hIA2_D1+%28NP_002837%29+PTPRN end obj|String*|0 end obj|String*|0 end end|FAE3C0 end obj|IxMolX obj|Molecule obj|BioObject obj|DBObj||\30:hIA2beta_D1 (NP_002838) PTPRN2|||||302014800|0|\227:protein tyrosine phosphatase, receptor type, N polypeptide 2 isoform 1 precursor; protein tyrosine phosphatase receptor pi; phogrin; tyrosine phosphatase IA-2 beta; IAR/receptor-like protein-tyrosine phosphatase [Homo sapiens]. end|2|2| obj|String*|0 end obj|String*|18|\64:REVIEWED REFSEQ: This record has been curated by NCBI staff. The|\60:reference sequence was derived from U66702.1 and AF007555.1.||\60:Summary: The protein encoded by this gene is a member of the|\63:protein tyrosine phosphatase (PTP) family. PTPs are known to be|\65:signaling molecules that regulate a variety of cellular processes|\58:including cell growth, differentiation, mitotic cycle, and|\61:oncogenic transformation. This PTP possesses an extracellular|\65:region, a single transmembrane region, and a single intracellular|\62:catalytic domain, and thus represents a receptor-type PTP. The|\55:catalytic domain of this PTP is most closely related to|\61:PTPRN/IA-2beta. This PTP and PTPRN are both found to be major|\65:autoantigens associated with insulin-dependent diabetes mellitus.|\67:Three alternatively spliced transcript variants of this gene, which|\45:encode distinct proteins, have been reported.||\64:Transcript Variant: This variant (1) encodes the longest isoform|(1). end obj|String*|44|\35:REFERENCE 1 (residues 1 to 1015)|\78: AUTHORS van den Maagdenberg,A.M., Schepens,J.T., Schepens,M.T., Pepers,B.,|\58: Wieringa,B., van Kessel,A.G. and Hendriks,W.J.|\73: TITLE Assignment of Ptprn2, the gene encoding receptor-type protein|\65: tyrosine phosphatase IA-2beta, a major autoantigen in|\79: insulin-dependent diabetes mellitus, to mouse chromosome region 12F|\59: JOURNAL Cytogenet. Cell Genet. 82 (3-4), 153-155 (1998)| MEDLINE 99077744|\35:REFERENCE 2 (residues 1 to 1015)|\68: AUTHORS Schmidli,R.S., Colman,P.G., Cui,L., Yu,W.P., Kewming,K.,|\74: Jankulovski,C., Harrison,L.C., Pallen,C.J. and DeAizpurua,H.J.|\76: TITLE Antibodies to the protein tyrosine phosphatases IAR and IA-2 are|\79: associated with progression to insulin-dependent diabetes (IDDM) in|\51: first-degree relatives at-risk for IDDM|\45: JOURNAL Autoimmunity 28 (1), 15-23 (1998)| MEDLINE 98425805|\35:REFERENCE 3 (residues 1 to 1015)|\66: AUTHORS Li,Q., Borovitskaya,A.E., DeSilva,M.G., Wasserfall,C.,|\52: Maclaren,N.K., Notkins,A.L. and Lan,M.S.|\74: TITLE Autoantigens in insulin-dependent diabetes mellitus: molecular|\59: cloning and characterization of human IA-2 beta|\63: JOURNAL Proc. Assoc. Am. Physicians 109 (4), 429-439 (1997)| MEDLINE 97364262|\35:REFERENCE 4 (residues 1 to 1015)|\69: AUTHORS Smith,P.D., Barker,K.T., Wang,J., Lu,Y.J., Shipley,J. and|\25: Crompton,M.R.|\76: TITLE ICAAR, a novel member of a new family of transmembrane, tyrosine|\37: phosphatase-like proteins|\66: JOURNAL Biochem. Biophys. Res. Commun. 229 (2), 402-411 (1996)| MEDLINE 97127415|\35:REFERENCE 5 (residues 1 to 1015)|\56: AUTHORS Kawasaki,E., Hutton,J.C. and Eisenbarth,G.S.|\77: TITLE Molecular cloning and characterization of the human transmembrane|\78: protein tyrosine phosphatase homologue, phogrin, an autoantigen of|\27: type 1 diabetes|\66: JOURNAL Biochem. Biophys. Res. Commun. 227 (2), 440-447 (1996)| MEDLINE 97032784|\35:REFERENCE 6 (residues 1 to 1015)|\75: AUTHORS Cui,L., Yu,W.P., DeAizpurua,H.J., Schmidli,R.S. and Pallen,C.J.|\70: TITLE Cloning and characterization of islet cell antigen-related|\77: protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and|\53: autoantigen in insulin-dependent diabetes|\55: JOURNAL J. Biol. Chem. 271 (40), 24817-24823 (1996)| MEDLINE 96394649 end obj|Object*|0 end obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp end obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/ end end|1|0|279 obj|Object*|4 obj|Feature obj|DBObj||Source_1|||||0|0| end|269|269|||0|1|279|1|1|1|1|1..279 obj|String*|4|\24:/organism="Homo sapiens"|\21:/db_xref="taxon:9606"|/chromosome="7"|/map="7q36" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Protein_1|||||0|0|\129:protein tyrosine phosphatase receptor pi; phogrin; tyrosine phosphatase IA-2 beta; IAR/receptor-like protein-tyrosine phosphatase end|270|270|||0|1|279|1|1|1|1|1..279 obj|String*|2|\56:/product="protein tyrosine phosphatase, receptor type, N|\34:polypeptide 2 isoform 1 precursor" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Chain_1|||||0|0| end|203|203|||0|1|279|1|1|1|1|1..279 obj|String*|2|\56:/product="protein tyrosine phosphatase, receptor type, N|\25:polypeptide 2, isoform 1" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Region_1|||||0|0|PTPc end|266|266|||0|17|278|1|1|1|1|17..278 obj|String*|3|\53:/region_name="Protein tyrosine phosphatase, catalytic|domain"|\25:/db_xref="CDD:smart00194" end|0|| obj|Object*|0 end end end|\279:hmilsymedhlknknrlekewealcayqaepnssfvaqreenvpknrslavltydhsrvllkaenshshsdyinaspimdhdprnpayiatqgplpatvadfwqmvwesgcvvivmltplaengvrqcyhywpdegsnlyhiyevnlvsehiwcedflvrsfylknlqtnetrtvtqfhflswydrgvpsssrslldfrrkvnkcyrgrscpiivhcsdgagrsgtyvlidmvlnkmakgakeidiaatlehlrdqrpgmvqtkeqfefaltavaeevn|GenPept| obj|String*|1|NP_002838 end||17-MAY-2003|\21:Homo sapiens (human). obj|String*|0 end|0 obj|String*|0 end|PRT obj|String*|0 end obj|String*|1|Homo sapiens end obj|String*|0 end obj|String*|0 end obj|String*|12|Eukaryota|Metazoa|Chordata|Craniata|Vertebrata|Euteleostomi|Mammalia|Eutheria|Primates|Catarrhini|Hominidae|Homo end obj|Object*|0 end obj|String*|0 end obj|String*|0 end obj|String*|1|\29:REFSEQ: accession NM_002847.2 end obj|String*|21|\56:VNTI URL:vnti:protein/hIA2beta_D1+%28NP_002838%29+PTPRN2|\56:VNTI URL:vnti:protein/hIA2beta_D1+%28NP_002838%29+PTPRN2|\56:VNTI URL:vnti:protein/hIA2beta_D1+%28NP_002838%29+PTPRN2|\56:VNTI URL:vnti:protein/hIA2beta_D1+%28NP_002838%29+PTPRN2|\56:VNTI URL:vnti:protein/hIA2beta_D1+%28NP_002838%29+PTPRN2|\56:VNTI URL:vnti:protein/hIA2beta_D1+%28NP_002838%29+PTPRN2|\56:VNTI URL:vnti:protein/hIA2beta_D1+%28NP_002838%29+PTPRN2|\56:VNTI URL:vnti:protein/hIA2beta_D1+%28NP_002838%29+PTPRN2|\56:VNTI URL:vnti:protein/hIA2beta_D1+%28NP_002838%29+PTPRN2|\56:VNTI URL:vnti:protein/hIA2beta_D1+%28NP_002838%29+PTPRN2|\56:VNTI URL:vnti:protein/hIA2beta_D1+%28NP_002838%29+PTPRN2|\56:VNTI URL:vnti:protein/hIA2beta_D1+%28NP_002838%29+PTPRN2|\56:VNTI URL:vnti:protein/hIA2beta_D1+%28NP_002838%29+PTPRN2|\56:VNTI URL:vnti:protein/hIA2beta_D1+%28NP_002838%29+PTPRN2|\56:VNTI URL:vnti:protein/hIA2beta_D1+%28NP_002838%29+PTPRN2|\56:VNTI URL:vnti:protein/hIA2beta_D1+%28NP_002838%29+PTPRN2|\56:VNTI URL:vnti:protein/hIA2beta_D1+%28NP_002838%29+PTPRN2|\56:VNTI URL:vnti:protein/hIA2beta_D1+%28NP_002838%29+PTPRN2|\56:VNTI URL:vnti:protein/hIA2beta_D1+%28NP_002838%29+PTPRN2|\56:VNTI URL:vnti:protein/hIA2beta_D1+%28NP_002838%29+PTPRN2|\56:VNTI URL:vnti:protein/hIA2beta_D1+%28NP_002838%29+PTPRN2 end obj|String*|0 end obj|String*|0 end end|FB3FB8 end obj|IxMolX obj|Molecule obj|BioObject obj|DBObj||\25:hLAR_D1 (NP_002831) PTPRF|||||302014800|0|\253:protein tyrosine phosphatase, receptor type, F isoform 1 precursor; protein tyrosine phosphatase, receptor type, F polypeptide; receptor-linked protein-tyrosine phosphatase LAR; leukocyte antigen-related tyrosine phosphatase; LCA-homolog [Homo sapiens]. end|2|2| obj|String*|0 end obj|String*|25|\64:REVIEWED REFSEQ: This record has been curated by NCBI staff. The|\60:reference sequence was derived from Y00815.1 and BI711143.1.||\60:Summary: The protein encoded by this gene is a member of the|\63:protein tyrosine phosphatase (PTP) family. PTPs are known to be|\65:signaling molecules that regulate a variety of cellular processes|\58:including cell growth, differentiation, mitotic cycle, and|\61:oncogenic transformation. This PTP possesses an extracellular|\53:region, a single transmembrane region, and two tandem|\57:intracytoplasmic catalytic domains, and thus represents a|\66:receptor-type PTP. The extracellular region contains three Ig-like|\56:domains, and nine non-Ig like domains similar to that of|\64:neural-cell adhesion molecule. This PTP was shown to function in|\60:the regulation of epithelial cell-cell contacts at adherents|\66:junctions, as well as in the control of beta-catenin signaling. An|\59:increased expression level of this protein was found in the|\66:insulin-responsive tissue of obese, insulin-resistant individuals,|\65:and may contribute to the pathogenesis of insulin resistance. Two|\61:alternatively spliced transcript variants of this gene, which|\45:encode distinct proteins, have been reported.||\63:Transcript Variant: This variant (1) contains an extra internal|\64:fragment within the coding region when compared to variant 2. It|\66:thus encodes a protein that has a 9 aa internal fragment absent in|isoform 2. end obj|String*|68|\35:REFERENCE 1 (residues 1 to 1897)|\74: AUTHORS Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J.|\72: TITLE Intra- and intermolecular interactions between intracellular|\61: domains of receptor protein-tyrosine phosphatases|\55: JOURNAL J. Biol. Chem. 277 (49), 47263-47269 (2002)| MEDLINE 22344739|\78: REMARK GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are|\75: a common but specific mechanism that is likely to be regulated-|\73: domain2s and the wedge structures are crucial determinants of|\73: binding specificity, thus regulating cross-talk between RPTPs|\35:REFERENCE 2 (residues 1 to 1897)|\51: AUTHORS Symons,J.R., LeVea,C.M. and Mooney,R.A.|\77: TITLE Expression of the leucocyte common antigen-related (LAR) tyrosine|\71: phosphatase is regulated by cell density through functional|\32: E-cadherin complexes|\50: JOURNAL Biochem. J. 365 (Pt 2), 513-519 (2002)| MEDLINE 22090243|\69: REMARK GeneRIF: regulation of expression by cell density through|\43: functional E-cadherin complexes|\35:REFERENCE 3 (residues 1 to 1897)|\71: AUTHORS Zabolotny,J.M., Kim,Y.B., Peroni,O.D., Kim,J.K., Pani,M.A.,|\74: Boss,O., Klaman,L.D., Kamatkar,S., Shulman,G.I., Kahn,B.B. and|\21: Neel,B.G.|\65: TITLE Overexpression of the LAR (leukocyte antigen-related)|\76: protein-tyrosine phosphatase in muscle causes insulin resistance|\66: JOURNAL Proc. Natl. Acad. Sci. U.S.A. 98 (9), 5187-5192 (2001)| MEDLINE 21221100|\35:REFERENCE 4 (residues 1 to 1897)|\62: AUTHORS Muller,T., Choidas,A., Reichmann,E. and Ullrich,A.|\74: TITLE Phosphorylation and free pool of beta-catenin are regulated by|\77: tyrosine kinases and tyrosine phosphatases during epithelial cell|\21: migration|\55: JOURNAL J. Biol. Chem. 274 (15), 10173-10183 (1999)| MEDLINE 99214576|\35:REFERENCE 5 (residues 1 to 1897)|\39: AUTHORS Ahmad,F. and Goldstein,B.J.|\71: TITLE Functional association between the insulin receptor and the|\74: transmembrane protein-tyrosine phosphatase LAR in intact cells|\50: JOURNAL J. Biol. Chem. 272 (1), 448-457 (1997)| MEDLINE 97150746|\35:REFERENCE 6 (residues 1 to 1897)|\53: AUTHORS Harder,K.W., Saw,J., Miki,N. and Jirik,F.|\77: TITLE Coexisting amplifications of the chromosome 1p32 genes (PTPRF and|\75: MYCL1) encoding protein tyrosine phosphatase LAR and L-myc in a|\39: small cell lung cancer line|\43: JOURNAL Genomics 27 (3), 552-553 (1995)| MEDLINE 96047346|\35:REFERENCE 7 (residues 1 to 1897)|\69: AUTHORS Schaapveld,R.Q., van den Maagdenberg,A.M., Schepens,J.T.,|\77: Weghuis,D.O., Geurts van Kessel,A., Wieringa,B. and Hendriks,W.J.|\78: TITLE The mouse gene Ptprf encoding the leukocyte common antigen-related|\68: molecule LAR: cloning, characterization, and chromosomal|\24: localization|\43: JOURNAL Genomics 27 (1), 124-130 (1995)| MEDLINE 95394448|\35:REFERENCE 8 (residues 1 to 1897)|\61: AUTHORS O'Grady,P., Krueger,N.X., Streuli,M. and Saito,H.|\78: TITLE Genomic organization of the human LAR protein tyrosine phosphatase|\74: gene and alternative splicing in the extracellular fibronectin|\28: type-III domains|\55: JOURNAL J. Biol. Chem. 269 (40), 25193-25199 (1994)| MEDLINE 95014301|\35:REFERENCE 9 (residues 1 to 1897)|\77: AUTHORS Streuli,M., Krueger,N.X., Hall,L.R., Schlossman,S.F. and Saito,H.|\69: TITLE A new member of the immunoglobulin superfamily that has a|\73: cytoplasmic region homologous to the leukocyte common antigen|\50: JOURNAL J. Exp. Med. 168 (5), 1523-1530 (1988)| MEDLINE 89035978 end obj|Object*|0 end obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp end obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/ end end|1|0|275 obj|Object*|4 obj|Feature obj|DBObj||Source_1|||||0|0| end|269|269|||0|1|275|1|1|1|1|1..275 obj|String*|4|\24:/organism="Homo sapiens"|\21:/db_xref="taxon:9606"|/chromosome="1"|/map="1p34" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Protein_1|||||0|0|\169:protein tyrosine phosphatase, receptor type, F polypeptide; receptor-linked protein-tyrosine phosphatase LAR; leukocyte antigen-related tyrosine phosphatase; LCA-homolog end|270|270|||0|1|275|1|1|1|1|1..275 obj|String*|3|\56:/product="protein tyrosine phosphatase, receptor type, F|isoform 1 precursor"|\21:/EC_number="3.1.3.48" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Chain_1|||||0|0| end|203|203|||0|1|275|1|1|1|1|1..275 obj|String*|2|\57:/product="protein tyrosine phosphatase, receptor type, F,|isoform 1" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Region_4|||||0|0|PTPc end|266|266|||0|17|272|1|1|1|1|17..272 obj|String*|3|\53:/region_name="Protein tyrosine phosphatase, catalytic|domain"|\25:/db_xref="CDD:smart00194" end|0|| obj|Object*|0 end end end|\275:tdladnierlkandglkfsqeyesidpgqqftwensnlevnkpknryanviaydhsrviltsidgvpgsdyinanyidgyrkqnayiatqgplpetmgdfwrmvweqrtatvvmmtrleeksrvkcdqywpargtetcgliqvtlldtvelatytvrtfalhksgssekrelrqfqfmawpdhgvpeyptpilaflrrvkacnpldagpmvvhcsagvgrtgcfividamlermkhektvdiyghvtcmrsqrnymvqtedqyvfihealleaat|GenPept| obj|String*|1|NP_002831 end||17-MAY-2003|\21:Homo sapiens (human). obj|String*|0 end|0 obj|String*|0 end|PRT obj|String*|0 end obj|String*|1|Homo sapiens end obj|String*|0 end obj|String*|0 end obj|String*|12|Eukaryota|Metazoa|Chordata|Craniata|Vertebrata|Euteleostomi|Mammalia|Eutheria|Primates|Catarrhini|Hominidae|Homo end obj|Object*|0 end obj|String*|0 end obj|String*|0 end obj|String*|1|\29:REFSEQ: accession NM_002840.2 end obj|String*|21|\51:VNTI URL:vnti:protein/hLAR_D1+%28NP_002831%29+PTPRF|\51:VNTI URL:vnti:protein/hLAR_D1+%28NP_002831%29+PTPRF|\51:VNTI URL:vnti:protein/hLAR_D1+%28NP_002831%29+PTPRF|\51:VNTI URL:vnti:protein/hLAR_D1+%28NP_002831%29+PTPRF|\51:VNTI URL:vnti:protein/hLAR_D1+%28NP_002831%29+PTPRF|\51:VNTI URL:vnti:protein/hLAR_D1+%28NP_002831%29+PTPRF|\51:VNTI URL:vnti:protein/hLAR_D1+%28NP_002831%29+PTPRF|\51:VNTI URL:vnti:protein/hLAR_D1+%28NP_002831%29+PTPRF|\51:VNTI URL:vnti:protein/hLAR_D1+%28NP_002831%29+PTPRF|\51:VNTI URL:vnti:protein/hLAR_D1+%28NP_002831%29+PTPRF|\51:VNTI URL:vnti:protein/hLAR_D1+%28NP_002831%29+PTPRF|\51:VNTI URL:vnti:protein/hLAR_D1+%28NP_002831%29+PTPRF|\51:VNTI URL:vnti:protein/hLAR_D1+%28NP_002831%29+PTPRF|\51:VNTI URL:vnti:protein/hLAR_D1+%28NP_002831%29+PTPRF|\51:VNTI URL:vnti:protein/hLAR_D1+%28NP_002831%29+PTPRF|\51:VNTI URL:vnti:protein/hLAR_D1+%28NP_002831%29+PTPRF|\51:VNTI URL:vnti:protein/hLAR_D1+%28NP_002831%29+PTPRF|\51:VNTI URL:vnti:protein/hLAR_D1+%28NP_002831%29+PTPRF|\51:VNTI URL:vnti:protein/hLAR_D1+%28NP_002831%29+PTPRF|\51:VNTI URL:vnti:protein/hLAR_D1+%28NP_002831%29+PTPRF|\51:VNTI URL:vnti:protein/hLAR_D1+%28NP_002831%29+PTPRF end obj|String*|0 end obj|String*|0 end end|FB62F8 end obj|IxMolX obj|Molecule obj|BioObject obj|DBObj||\28:hLyPTP_D1 (NP_057051) PTPN22|||||302014800|0|\158:lymphoid-specific protein tyrosine phosphatase isoform 1; lymphoid-specific protein tyrosine phosphatase; protein tyrosine phosphatase homolog [Homo sapiens]. end|2|2| obj|String*|0 end obj|String*|13|\64:REVIEWED REFSEQ: This record has been curated by NCBI staff. The|\62:reference sequence was derived from AF077031.1 and AF001846.1.||\66:Summary: This gene encodes a protein tyrosine phosphatase which is|\63:expressed primarily in lymphoid tissues. This enzyme associates|\61:with the molecular adapter protein CBL and may be involved in|\65:regulating CBL function in the T-cell receptor signaling pathway.|\59:Alternative splicing of this gene results in two transcript|\36:variants encoding distinct isoforms.||\67:Transcript Variant: This variant (1) encodes the longer isoform (1)|\56:which is 116 aa longer than isoform 2 and has a distinct|C-terminus. end obj|String*|16|\34:REFERENCE 1 (residues 1 to 807)|\78: AUTHORS Hill,R.J., Zozulya,S., Lu,Y.L., Ward,K., Gishizky,M. and Jallal,B.|\76: TITLE The lymphoid protein tyrosine phosphatase Lyp interacts with the|\74: adaptor molecule Grb2 and functions as a negative regulator of|\29: T-cell activation|\48: JOURNAL Exp. Hematol. 30 (3), 237-244 (2002)| MEDLINE 21876996|\77: REMARK GeneRIF: data demonstrate a novel interaction between Lyp and the|\79: adaptor Grb2 and are consistent with a negative regulatory role for|\36: Lyp in T-cell signaling.|\34:REFERENCE 2 (residues 1 to 807)|\68: AUTHORS Cohen,S., Dadi,H., Shaoul,E., Sharfe,N. and Roifman,C.M.|\74: TITLE Cloning and characterization of a lymphoid-specific, inducible|\51: human protein tyrosine phosphatase, Lyp|\42: JOURNAL Blood 93 (6), 2013-2024 (1999)| MEDLINE 99168989 end obj|Object*|0 end obj|CreatorData|||||\28:jannik@noergaardandersen.com|||JNA||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp end obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/ end end|1|0|287 obj|Object*|3 obj|Feature obj|DBObj||Source_1|||||0|0| end|269|269|||0|1|287|1|1|1|1|1..287 obj|String*|4|\24:/organism="Homo sapiens"|\21:/db_xref="taxon:9606"|/chromosome="1"|/map="1p13.3-p13.1" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Protein_1|||||0|0|\84:lymphoid-specific protein tyrosine phosphatase; protein tyrosine phosphatase homolog end|270|270|||0|1|287|1|1|1|1|1..287 obj|String*|2|\56:/product="lymphoid-specific protein tyrosine phosphatase|isoform 1" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Region_1|||||0|0|PTPc end|266|266|||0|20|287|1|1|1|1|20..287 obj|String*|3|\53:/region_name="Protein tyrosine phosphatase, catalytic|domain"|\25:/db_xref="CDD:smart00194" end|0|| obj|Object*|0 end end end|\287:eilqkfldeaqskkitkeefaneflklkrqstkykadktypttvaekpknikknrykdilpydysrvelslitsdedssyinanfikgvygpkayiatqgplsttlldfwrmiweysvliigmacmeyemgkkkcerywaepvemqlefgpfsvsceaekrksdyiirtlkvkfnsetrtiyqfhyknwpdhdvpssidpileliwdvrcyqeddsvpicihcsagcgrtgvicaidytwmllkdgiipenfsvfsliremrtqrpslvqtqeqyelvynavlelfk|GenPept| obj|String*|1|NP_057051 end||30-JUN-2003|\21:Homo sapiens (human). obj|String*|0 end|0 obj|String*|0 end|PRT obj|String*|0 end obj|String*|1|Homo sapiens end obj|String*|0 end obj|String*|0 end obj|String*|12|Eukaryota|Metazoa|Chordata|Craniata|Vertebrata|Euteleostomi|Mammalia|Eutheria|Primates|Catarrhini|Hominidae|Homo end obj|Object*|0 end obj|String*|0 end obj|String*|0 end obj|String*|1|\29:REFSEQ: accession NM_015967.2 end obj|String*|21|\54:VNTI URL:vnti:protein/hLyPTP_D1+%28NP_057051%29+PTPN22|\54:VNTI URL:vnti:protein/hLyPTP_D1+%28NP_057051%29+PTPN22|\54:VNTI URL:vnti:protein/hLyPTP_D1+%28NP_057051%29+PTPN22|\54:VNTI URL:vnti:protein/hLyPTP_D1+%28NP_057051%29+PTPN22|\54:VNTI URL:vnti:protein/hLyPTP_D1+%28NP_057051%29+PTPN22|\54:VNTI URL:vnti:protein/hLyPTP_D1+%28NP_057051%29+PTPN22|\54:VNTI URL:vnti:protein/hLyPTP_D1+%28NP_057051%29+PTPN22|\54:VNTI URL:vnti:protein/hLyPTP_D1+%28NP_057051%29+PTPN22|\54:VNTI URL:vnti:protein/hLyPTP_D1+%28NP_057051%29+PTPN22|\54:VNTI URL:vnti:protein/hLyPTP_D1+%28NP_057051%29+PTPN22|\54:VNTI URL:vnti:protein/hLyPTP_D1+%28NP_057051%29+PTPN22|\54:VNTI URL:vnti:protein/hLyPTP_D1+%28NP_057051%29+PTPN22|\54:VNTI URL:vnti:protein/hLyPTP_D1+%28NP_057051%29+PTPN22|\54:VNTI URL:vnti:protein/hLyPTP_D1+%28NP_057051%29+PTPN22|\54:VNTI URL:vnti:protein/hLyPTP_D1+%28NP_057051%29+PTPN22|\54:VNTI URL:vnti:protein/hLyPTP_D1+%28NP_057051%29+PTPN22|\54:VNTI URL:vnti:protein/hLyPTP_D1+%28NP_057051%29+PTPN22|\54:VNTI URL:vnti:protein/hLyPTP_D1+%28NP_057051%29+PTPN22|\54:VNTI URL:vnti:protein/hLyPTP_D1+%28NP_057051%29+PTPN22|\54:VNTI URL:vnti:protein/hLyPTP_D1+%28NP_057051%29+PTPN22|\54:VNTI URL:vnti:protein/hLyPTP_D1+%28NP_057051%29+PTPN22 end obj|String*|0 end obj|String*|0 end end|FBC030 end obj|IxMolX obj|Molecule obj|BioObject obj|DBObj||\26:hMEG1_D1 (NP_002821) PTPN4|||||302014800|0|\184:protein tyrosine phosphatase, non-receptor type 4; megakaryocyte phosphatase; PTPase-MEG1; protein tyrosine phosphatase MEG1; megakaryocyte protein-tyrosine phosphatase [Homo sapiens]. end|2|2| obj|String*|0 end obj|String*|13|\64:REVIEWED REFSEQ: This record has been curated by NCBI staff. The|\60:reference sequence was derived from M68941.1 and BC010674.1.||\60:Summary: The protein encoded by this gene is a member of the|\63:protein tyrosine phosphatase (PTP) family. PTPs are known to be|\65:signaling molecules that regulate a variety of cellular processes|\58:including cell growth, differentiation, mitotic cycle, and|\64:oncogenic transformation. This protein contains a C-terminal PTP|\58:domain and an N-terminal domain homologous to the band 4.1|\66:superfamily of cytoskeletal-associated proteins. This PTP has been|\61:shown to interact with glutamate receptor delta 2 and epsilon|\67:subunits, and is thought to play a role in signalling downstream of|\59:the glutamate receptors through tyrosine dephosphorylation. end obj|String*|25|\34:REFERENCE 1 (residues 1 to 926)|\74: AUTHORS Hironaka,K., Umemori,H., Tezuka,T., Mishina,M. and Yamamoto,T.|\76: TITLE The protein-tyrosine phosphatase PTPMEG interacts with glutamate|\49: receptor delta 2 and epsilon subunits|\55: JOURNAL J. Biol. Chem. 275 (21), 16167-16173 (2000)| MEDLINE 20283654|\34:REFERENCE 2 (residues 1 to 926)|\43: AUTHORS Gu,M., Meng,K. and Majerus,P.W.|\76: TITLE The effect of overexpression of the protein tyrosine phosphatase|\79: PTPMEG on cell growth and on colony formation in soft agar in COS-7| cells|\69: JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (23), 12980-12985 (1996)| MEDLINE 97075104|\34:REFERENCE 3 (residues 1 to 926)|\34: AUTHORS Gu,M. and Majerus,P.W.|\69: TITLE The properties of the protein tyrosine phosphatase PTPMEG|\55: JOURNAL J. Biol. Chem. 271 (44), 27751-27759 (1996)| MEDLINE 97066967|\34:REFERENCE 4 (residues 1 to 926)|\62: AUTHORS Gu,M.X., York,J.D., Warshawsky,I. and Majerus,P.W.|\66: TITLE Identification, cloning, and expression of a cytosolic|\77: megakaryocyte protein-tyrosine-phosphatase with sequence homology|\39: to cytoskeletal protein 4.1|\67: JOURNAL Proc. Natl. Acad. Sci. U.S.A. 88 (13), 5867-5871 (1991)| MEDLINE 91288564 end obj|Object*|0 end obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp end obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/ end end|1|0|277 obj|Object*|3 obj|Feature obj|DBObj||Source_1|||||0|0| end|269|269|||0|1|277|1|1|1|1|1..277 obj|String*|4|\24:/organism="Homo sapiens"|\21:/db_xref="taxon:9606"|/chromosome="2"|/map="2q14.1" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Protein_1|||||0|0|\117:megakaryocyte phosphatase; PTPase-MEG1; protein tyrosine phosphatase MEG1; megakaryocyte protein-tyrosine phosphatase end|270|270|||0|1|277|1|1|1|1|1..277 obj|String*|3|\57:/product="protein tyrosine phosphatase, non-receptor type|4"|\21:/EC_number="3.1.3.48" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Region_1|||||0|0|PTPc end|266|266|||0|19|277|1|1|1|1|19..277 obj|String*|3|\53:/region_name="Protein tyrosine phosphatase, catalytic|domain"|\25:/db_xref="CDD:smart00194" end|0|| obj|Object*|0 end end end|\277:hslresmiqlaeglitgtvltqfdqlyrkkpgmtmscaklpqnisknryrdispydatrvilkgnedyinanyinmeipsssiinqyiacqgplphtctdfwqmtweqgssmvvmlttqvergrvkchqywpeptgsssygcyqvtchseegntayifrkmtlfnqeknesrpltqiqyiawpdhgvpddssdfldfvchvrnkragkeepvvvhcsagigrtgvlitmetamcliecnqpvypldivrtmrdqrammiqtpsqyrfvceailkvye|GenPept| obj|String*|1|NP_002821 end||17-MAY-2003|\21:Homo sapiens (human). obj|String*|0 end|0 obj|String*|0 end|PRT obj|String*|0 end obj|String*|1|Homo sapiens end obj|String*|0 end obj|String*|0 end obj|String*|12|Eukaryota|Metazoa|Chordata|Craniata|Vertebrata|Euteleostomi|Mammalia|Eutheria|Primates|Catarrhini|Hominidae|Homo end obj|Object*|0 end obj|String*|0 end obj|String*|0 end obj|String*|1|\29:REFSEQ: accession NM_002830.2 end obj|String*|21|\52:VNTI URL:vnti:protein/hMEG1_D1+%28NP_002821%29+PTPN4|\52:VNTI URL:vnti:protein/hMEG1_D1+%28NP_002821%29+PTPN4|\52:VNTI URL:vnti:protein/hMEG1_D1+%28NP_002821%29+PTPN4|\52:VNTI URL:vnti:protein/hMEG1_D1+%28NP_002821%29+PTPN4|\52:VNTI URL:vnti:protein/hMEG1_D1+%28NP_002821%29+PTPN4|\52:VNTI URL:vnti:protein/hMEG1_D1+%28NP_002821%29+PTPN4|\52:VNTI URL:vnti:protein/hMEG1_D1+%28NP_002821%29+PTPN4|\52:VNTI URL:vnti:protein/hMEG1_D1+%28NP_002821%29+PTPN4|\52:VNTI URL:vnti:protein/hMEG1_D1+%28NP_002821%29+PTPN4|\52:VNTI URL:vnti:protein/hMEG1_D1+%28NP_002821%29+PTPN4|\52:VNTI URL:vnti:protein/hMEG1_D1+%28NP_002821%29+PTPN4|\52:VNTI URL:vnti:protein/hMEG1_D1+%28NP_002821%29+PTPN4|\52:VNTI URL:vnti:protein/hMEG1_D1+%28NP_002821%29+PTPN4|\52:VNTI URL:vnti:protein/hMEG1_D1+%28NP_002821%29+PTPN4|\52:VNTI URL:vnti:protein/hMEG1_D1+%28NP_002821%29+PTPN4|\52:VNTI URL:vnti:protein/hMEG1_D1+%28NP_002821%29+PTPN4|\52:VNTI URL:vnti:protein/hMEG1_D1+%28NP_002821%29+PTPN4|\52:VNTI URL:vnti:protein/hMEG1_D1+%28NP_002821%29+PTPN4|\52:VNTI URL:vnti:protein/hMEG1_D1+%28NP_002821%29+PTPN4|\52:VNTI URL:vnti:protein/hMEG1_D1+%28NP_002821%29+PTPN4|\52:VNTI URL:vnti:protein/hMEG1_D1+%28NP_002821%29+PTPN4 end obj|String*|0 end obj|String*|0 end end|FBE0A8 end obj|IxMolX obj|Molecule obj|BioObject obj|DBObj||\26:hMEG2_D1 (NP_002824) PTPN9|||||302014800|0|\113:protein tyrosine phosphatase, non-receptor type 9; protein-tyrosine phosphatase MEG2; PTPase-MEG2 [Homo sapiens]. end|2|2| obj|String*|0 end obj|String*|13|\64:REVIEWED REFSEQ: This record has been curated by NCBI staff. The|\45:reference sequence was derived from M83738.1.||\60:Summary: The protein encoded by this gene is a member of the|\63:protein tyrosine phosphatase (PTP) family. PTPs are known to be|\65:signaling molecules that regulate a variety of cellular processes|\58:including cell growth, differentiation, mitotic cycle, and|\64:oncogenic transformation. This PTP contains an N-terminal domain|\65:that shares a significant similarity with yeast SEC14, which is a|\62:protein that has phosphatidylinositol transfer activity and is|\66:required for protein secretion through the Golgi complex in yeast.|\66:This PTP was found to be activated by polyphosphoinositide, and is|\67:thought to be involved in signaling events regulating phagocytosis. end obj|String*|23|\34:REFERENCE 1 (residues 1 to 593)|\69: AUTHORS Qi,Y., Zhao,R., Cao,H., Sui,X., Krantz,S.B. and Zhao,Z.J.|\77: TITLE Purification and characterization of protein tyrosine phosphatase| PTP-MEG2|\50: JOURNAL J. Cell. Biochem. 86 (1), 79-89 (2002)| MEDLINE 22106294|\74: REMARK GeneRIF: Purification and characterization of protein tyrosine|\32: phosphatase PTP-MEG2|\34:REFERENCE 2 (residues 1 to 593)|\78: AUTHORS Kruger,J.M., Fukushima,T., Cherepanov,V., Borregaard,N., Loeve,C.,|\72: Shek,C., Sharma,K., Tanswell,A.K., Chow,C.W. and Downey,G.P.|\67: TITLE Protein-tyrosine phosphatase MEG2 is expressed by human|\72: neutrophils. Localization to the phagosome and activation by|\33: polyphosphoinositides|\52: JOURNAL J. Biol. Chem. 277 (4), 2620-2628 (2002)| MEDLINE 21659736|\34:REFERENCE 3 (residues 1 to 593)|\49: AUTHORS Gu,M., Warshawsky,I. and Majerus,P.W.|\63: TITLE Cloning and expression of a cytosolic megakaryocyte|\66: protein-tyrosine-phosphatase with sequence homology to|\58: retinaldehyde-binding protein and yeast SEC14p|\66: JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (7), 2980-2984 (1992)| MEDLINE 92212952 end obj|Object*|0 end obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp end obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/ end end|1|0|291 obj|Object*|3 obj|Feature obj|DBObj||Source_1|||||0|0| end|269|269|||0|1|291|1|1|1|1|1..291 obj|String*|4|\24:/organism="Homo sapiens"|\21:/db_xref="taxon:9606"|/chromosome="15"|/map="15q23" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Protein_1|||||0|0|\46:protein-tyrosine phosphatase MEG2; PTPase-MEG2 end|270|270|||0|1|291|1|1|1|1|1..291 obj|String*|3|\57:/product="protein tyrosine phosphatase, non-receptor type|9"|\21:/EC_number="3.1.3.48" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Region_1|||||0|0|PTPc end|266|266|||0|17|291|1|1|1|1|17..291 obj|String*|3|\53:/region_name="Protein tyrosine phosphatase, catalytic|domain"|\25:/db_xref="CDD:smart00194" end|0|| obj|Object*|0 end end end|\291:mtiqelvdyvnarqkqgiyeeyedirrenpvgtfhcsmspgnleknrygdvpcldqtrvkltkrsghtqtdyinasfmdgykqknayigtqgplentyrdfwlmvweqkvlvivmttrfeeggrrkcgqywplekdsrirfgfltvtnlgvenmnhykkttleihnteerqkrqvthfqflswpdygvpssaaslidflrvvrnqqslavsnmgarskgqcpeppivvhcsagigrtgtfcsldiclaqleelgtlnvfqtvsrmrtqrafsiqtpeqyyfcykailefae|GenPept| obj|String*|1|NP_002824 end||17-MAY-2003|\21:Homo sapiens (human). obj|String*|0 end|0 obj|String*|0 end|PRT obj|String*|0 end obj|String*|1|Homo sapiens end obj|String*|0 end obj|String*|0 end obj|String*|12|Eukaryota|Metazoa|Chordata|Craniata|Vertebrata|Euteleostomi|Mammalia|Eutheria|Primates|Catarrhini|Hominidae|Homo end obj|Object*|0 end obj|String*|0 end obj|String*|0 end obj|String*|1|\29:REFSEQ: accession NM_002833.2 end obj|String*|21|\52:VNTI URL:vnti:protein/hMEG2_D1+%28NP_002824%29+PTPN9|\52:VNTI URL:vnti:protein/hMEG2_D1+%28NP_002824%29+PTPN9|\52:VNTI URL:vnti:protein/hMEG2_D1+%28NP_002824%29+PTPN9|\52:VNTI URL:vnti:protein/hMEG2_D1+%28NP_002824%29+PTPN9|\52:VNTI URL:vnti:protein/hMEG2_D1+%28NP_002824%29+PTPN9|\52:VNTI URL:vnti:protein/hMEG2_D1+%28NP_002824%29+PTPN9|\52:VNTI URL:vnti:protein/hMEG2_D1+%28NP_002824%29+PTPN9|\52:VNTI URL:vnti:protein/hMEG2_D1+%28NP_002824%29+PTPN9|\52:VNTI URL:vnti:protein/hMEG2_D1+%28NP_002824%29+PTPN9|\52:VNTI URL:vnti:protein/hMEG2_D1+%28NP_002824%29+PTPN9|\52:VNTI URL:vnti:protein/hMEG2_D1+%28NP_002824%29+PTPN9|\52:VNTI URL:vnti:protein/hMEG2_D1+%28NP_002824%29+PTPN9|\52:VNTI URL:vnti:protein/hMEG2_D1+%28NP_002824%29+PTPN9|\52:VNTI URL:vnti:protein/hMEG2_D1+%28NP_002824%29+PTPN9|\52:VNTI URL:vnti:protein/hMEG2_D1+%28NP_002824%29+PTPN9|\52:VNTI URL:vnti:protein/hMEG2_D1+%28NP_002824%29+PTPN9|\52:VNTI URL:vnti:protein/hMEG2_D1+%28NP_002824%29+PTPN9|\52:VNTI URL:vnti:protein/hMEG2_D1+%28NP_002824%29+PTPN9|\52:VNTI URL:vnti:protein/hMEG2_D1+%28NP_002824%29+PTPN9|\52:VNTI URL:vnti:protein/hMEG2_D1+%28NP_002824%29+PTPN9|\52:VNTI URL:vnti:protein/hMEG2_D1+%28NP_002824%29+PTPN9 end obj|String*|0 end obj|String*|0 end end|FC0230 end obj|IxMolX obj|Molecule obj|BioObject obj|DBObj||\28:hPCPTP1_D1 (NP_002840) PTPRR|||||302014800|0|\234:protein tyrosine phosphatase, receptor type, R isoform 1 precursor; protein tyrosine phosphatase, receptor type, Q; protein-tyrosine phosphatase NC-PTPCOM1; protein tyrosine phosphatase Cr1PTPase precursor; Ch-1 PTPase [Homo sapiens]. end|2|2| obj|String*|0 end obj|String*|20|\64:REVIEWED REFSEQ: This record has been curated by NCBI staff. The|\45:reference sequence was derived from D64053.1.||\60:Summary: The protein encoded by this gene is a member of the|\63:protein tyrosine phosphatase (PTP) family. PTPs are known to be|\65:signaling molecules that regulate a variety of cellular processes|\58:including cell growth, differentiation, mitotic cycle, and|\61:oncogenic transformation. This PTP possesses an extracellular|\65:region, a single transmembrane region, and a single intracellular|\63:catalytic domains, and thus represents a receptor-type PTP. The|\64:similar gene predominately expressed in mouse brain was found to|\59:associate with, and thus regulate the activity and cellular|\65:localization of MAP kinases. The rat counterpart of this gene was|\58:reported to be regulated by the nerve growth factor, which|\58:suggested the function of this gene in neuronal growth and|differentiation.||\64:Transcript Variant: This variant (1) contains a different 5' end|\65:region when compared to variant 2. It thus encodes a protein that|\50:has a longer N-terminus, as compared to isoform 2. end obj|String*|26|\34:REFERENCE 1 (residues 1 to 657)|\55: AUTHORS Blanco-Aparicio,C., Torres,J. and Pulido,R.|\78: TITLE A novel regulatory mechanism of MAP kinases activation and nuclear|\77: translocation mediated by PKA and the PTP-SL tyrosine phosphatase|\51: JOURNAL J. Cell Biol. 147 (6), 1129-1136 (1999)| MEDLINE 20069779|\34:REFERENCE 2 (residues 1 to 657)|\77: AUTHORS Shiozuka,K., Watanabe,Y., Ikeda,T., Hashimoto,S. and Kawashima,H.|\70: TITLE Cloning and expression of PCPTP1 encoding protein tyrosine|\23: phosphatase|\40: JOURNAL Gene 162 (2), 279-284 (1995)| MEDLINE 96032358|\48: REMARK founctional study of the rat homolog|\34:REFERENCE 3 (residues 1 to 657)|\57: AUTHORS Ogata,M., Sawada,M., Fujino,Y. and Hamaoka,T.|\78: TITLE cDNA cloning and characterization of a novel receptor-type protein|\69: tyrosine phosphatase expressed predominantly in the brain|\52: JOURNAL J. Biol. Chem. 270 (5), 2337-2343 (1995)| MEDLINE 95138207|\49: REMARK functional study of the mouse homolog|\34:REFERENCE 4 (residues 1 to 657)|\39: AUTHORS Sharma,E. and Lombroso,P.J.|\75: TITLE A neuronal protein tyrosine phosphatase induced by nerve growth| factor|\48: JOURNAL J. Biol. Chem. 270 (1), 49-53 (1995)| MEDLINE 95113874 end obj|Object*|0 end obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp end obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/ end end|1|0|275 obj|Object*|4 obj|Feature obj|DBObj||Source_1|||||0|0| end|269|269|||0|1|275|1|1|1|1|1..275 obj|String*|4|\24:/organism="Homo sapiens"|\21:/db_xref="taxon:9606"|/chromosome="12"|/map="12q15" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Protein_1|||||0|0|\150:protein tyrosine phosphatase, receptor type, Q; protein-tyrosine phosphatase NC-PTPCOM1; protein tyrosine phosphatase Cr1PTPase precursor; Ch-1 PTPase end|270|270|||0|1|275|1|1|1|1|1..275 obj|String*|2|\56:/product="protein tyrosine phosphatase, receptor type, R|isoform 1 precursor" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Chain_1|||||0|0| end|203|203|||0|1|275|1|1|1|1|1..275 obj|String*|2|\56:/product="protein tyrosine phosphatase, receptor type, R|isoform 1" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Region_1|||||0|0|PTPc end|266|266|||0|18|273|1|1|1|1|18..273 obj|String*|3|\53:/region_name="Protein tyrosine phosphatase, catalytic|domain"|\25:/db_xref="CDD:smart00194" end|0|| obj|Object*|0 end end end|\275:sriltrsqlrdvvasshllqsefmeipmnfvdpkeidiprhgtknryktilpnplsrvclrpknvtdslstyinanyirgysgkekafiatqgpmintvddfwqmvwqedspvivmitklkeknekcvlywpekrgiygkvevlvisvnecdnytirnlvlkqgshtqhvkhywytswpdhktpdsaqpllqlmldveedrlasqgrgpvvvhcsagigrtgcfiatsigcqqlkeegvvdalsivcqlrmdrggmvqtseqyefvhhalclyes|GenPept| obj|String*|1|NP_002840 end||17-MAY-2003|\21:Homo sapiens (human). obj|String*|0 end|0 obj|String*|0 end|PRT obj|String*|0 end obj|String*|1|Homo sapiens end obj|String*|0 end obj|String*|0 end obj|String*|12|Eukaryota|Metazoa|Chordata|Craniata|Vertebrata|Euteleostomi|Mammalia|Eutheria|Primates|Catarrhini|Hominidae|Homo end obj|Object*|0 end obj|String*|0 end obj|String*|0 end obj|String*|1|\29:REFSEQ: accession NM_002849.2 end obj|String*|21|\54:VNTI URL:vnti:protein/hPCPTP1_D1+%28NP_002840%29+PTPRR|\54:VNTI URL:vnti:protein/hPCPTP1_D1+%28NP_002840%29+PTPRR|\54:VNTI URL:vnti:protein/hPCPTP1_D1+%28NP_002840%29+PTPRR|\54:VNTI URL:vnti:protein/hPCPTP1_D1+%28NP_002840%29+PTPRR|\54:VNTI URL:vnti:protein/hPCPTP1_D1+%28NP_002840%29+PTPRR|\54:VNTI URL:vnti:protein/hPCPTP1_D1+%28NP_002840%29+PTPRR|\54:VNTI URL:vnti:protein/hPCPTP1_D1+%28NP_002840%29+PTPRR|\54:VNTI URL:vnti:protein/hPCPTP1_D1+%28NP_002840%29+PTPRR|\54:VNTI URL:vnti:protein/hPCPTP1_D1+%28NP_002840%29+PTPRR|\54:VNTI URL:vnti:protein/hPCPTP1_D1+%28NP_002840%29+PTPRR|\54:VNTI URL:vnti:protein/hPCPTP1_D1+%28NP_002840%29+PTPRR|\54:VNTI URL:vnti:protein/hPCPTP1_D1+%28NP_002840%29+PTPRR|\54:VNTI URL:vnti:protein/hPCPTP1_D1+%28NP_002840%29+PTPRR|\54:VNTI URL:vnti:protein/hPCPTP1_D1+%28NP_002840%29+PTPRR|\54:VNTI URL:vnti:protein/hPCPTP1_D1+%28NP_002840%29+PTPRR|\54:VNTI URL:vnti:protein/hPCPTP1_D1+%28NP_002840%29+PTPRR|\54:VNTI URL:vnti:protein/hPCPTP1_D1+%28NP_002840%29+PTPRR|\54:VNTI URL:vnti:protein/hPCPTP1_D1+%28NP_002840%29+PTPRR|\54:VNTI URL:vnti:protein/hPCPTP1_D1+%28NP_002840%29+PTPRR|\54:VNTI URL:vnti:protein/hPCPTP1_D1+%28NP_002840%29+PTPRR|\54:VNTI URL:vnti:protein/hPCPTP1_D1+%28NP_002840%29+PTPRR end obj|String*|0 end obj|String*|0 end end|FC2330 end obj|IxMolX obj|Molecule obj|BioObject obj|DBObj||\27:hPEST_D1 (NP_002826) PTPN12|||||302014800|0|\99:protein tyrosine phosphatase, non-receptor type 12; protein-tyrosine phosphatase G1 [Homo sapiens]. end|2|2| obj|String*|0 end obj|String*|17|\64:REVIEWED REFSEQ: This record has been curated by NCBI staff. The|\45:reference sequence was derived from M93425.1.|\58:On Jan 25, 2002 this sequence version replaced gi:4506287.||\60:Summary: The protein encoded by this gene is a member of the|\63:protein tyrosine phosphatase (PTP) family. PTPs are known to be|\65:signaling molecules that regulate a variety of cellular processes|\58:including cell growth, differentiation, mitotic cycle, and|\61:oncogenic transformation. This PTP contains a C-terminal PEST|\64:motif, which serves as a protein-protein interaction domain, and|\63:may be related to protein intracellular half-life. This PTP was|\64:found to bind and dephosphorylate the product of oncogene c-ABL,|\67:thus may play a role in oncogenesis. This PTP was shown to interact|\59:with, and dephosphorylate, various of cytoskeleton and cell|\67:adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and|\66:paxillin, which suggested its regulatory roles in controlling cell|shape and mobility. end obj|String*|54|\34:REFERENCE 1 (residues 1 to 780)|\67: AUTHORS Lyons,P.D., Dunty,J.M., Schaefer,E.M. and Schaller,M.D.|\77: TITLE Inhibition of the catalytic activity of cell adhesion kinase beta|\75: by protein-tyrosine phosphatase-PEST-mediated dephosphorylation|\55: JOURNAL J. Biol. Chem. 276 (26), 24422-24431 (2001)| MEDLINE 21316574|\34:REFERENCE 2 (residues 1 to 780)|\76: AUTHORS Cong,F., Spencer,S., Cote,J.F., Wu,Y., Tremblay,M.L., Lasky,L.A.|\25: and Goff,S.P.|\79: TITLE Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine|\76: phosphatase to the c-Abl kinase to mediate Abl dephosphorylation|\45: JOURNAL Mol. Cell 6 (6), 1413-1423 (2000)| MEDLINE 21111050|\34:REFERENCE 3 (residues 1 to 780)|\79: AUTHORS Shen,Y., Lyons,P., Cooley,M., Davidson,D., Veillette,A., Salgia,R.,|\42: Griffin,J.D. and Schaller,M.D.|\72: TITLE The noncatalytic domain of protein-tyrosine phosphatase-PEST|\58: targets paxillin for dephosphorylation in vivo|\52: JOURNAL J. Biol. Chem. 275 (2), 1405-1413 (2000)| MEDLINE 20092920|\34:REFERENCE 4 (residues 1 to 780)|\79: AUTHORS Nishiya,N., Iwabuchi,Y., Shibanuma,M., Cote,J.F., Tremblay,M.L. and| Nose,K.|\70: TITLE Hic-5, a paxillin homologue, binds to the protein-tyrosine|\64: phosphatase PEST (PTP-PEST) through its LIM 3 domain|\53: JOURNAL J. Biol. Chem. 274 (14), 9847-9853 (1999)| MEDLINE 99194842|\34:REFERENCE 5 (residues 1 to 780)|\38: AUTHORS Garton,A.J. and Tonks,N.K.|\69: TITLE Regulation of fibroblast motility by the protein tyrosine|\32: phosphatase PTP-PEST|\52: JOURNAL J. Biol. Chem. 274 (6), 3811-3818 (1999)| MEDLINE 99121127|\34:REFERENCE 6 (residues 1 to 780)|\79: AUTHORS Takekawa,M., Itoh,F., Hinoda,Y., Adachi,M., Ariyama,T., Inazawa,J.,|\32: Imai,K. and Yachi,A.|\75: TITLE Chromosomal localization of the protein tyrosine phosphatase G1|\74: gene and characterization of the aberrant transcripts in human|\30: colon cancer cells|\46: JOURNAL FEBS Lett. 339 (3), 222-228 (1994)| MEDLINE 94156037|\34:REFERENCE 7 (residues 1 to 780)|\56: AUTHORS Yang,Q., Co,D., Sommercorn,J. and Tonks,N.K.|\63: TITLE Cloning and expression of PTP-PEST. A novel, human,|\57: nontransmembrane protein tyrosine phosphatase|\52: JOURNAL J. Biol. Chem. 268 (9), 6622-6628 (1993)| MEDLINE 93203262|\34:REFERENCE 8 (residues 1 to 780)|\78: AUTHORS Takekawa,M., Itoh,F., Hinoda,Y., Arimura,Y., Toyota,M., Sekiya,M.,|\43: Adachi,M., Imai,K. and Yachi,A.|\73: TITLE Cloning and characterization of a human cDNA encoding a novel|\61: putative cytoplasmic protein-tyrosine-phosphatase|\68: JOURNAL Biochem. Biophys. Res. Commun. 189 (2), 1223-1230 (1992)| MEDLINE 93112015 end obj|Object*|0 end obj|CreatorData|||||\28:jannik@noergaardandersen.com|||JNA||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp end obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/ end end|1|0|288 obj|Object*|3 obj|Feature obj|DBObj||Source_1|||||0|0| end|269|269|||0|1|288|1|1|1|1|1..288 obj|String*|4|\24:/organism="Homo sapiens"|\21:/db_xref="taxon:9606"|/chromosome="7"|/map="7q11.23" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Protein_1|||||0|0|\31:protein-tyrosine phosphatase G1 end|270|270|||0|1|288|1|1|1|1|1..288 obj|String*|3|\57:/product="protein tyrosine phosphatase, non-receptor type|12"|\21:/EC_number="3.1.3.48" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Region_1|||||0|0|PTPc end|266|266|||0|21|288|1|1|1|1|21..288 obj|String*|3|\53:/region_name="Protein tyrosine phosphatase, catalytic|domain"|\25:/db_xref="CDD:smart00194" end|0|| obj|Object*|0 end end end|\288:rkfiqrvqamkspdhngednfardfmrlrrlstkyrtekiyptatgekeenvkknrykdilpfdhsrvkltlktpsqdsdyinanfikgvygpkayvatqgplantvidfwrmiweynvviivmacrefemgrkkcerywplygedpitfapfkiscedeqartdyfirtlllefqnesrrlyqfhyvnwpdhdvpssfdsildmislmrkyqehedvpicihcsagcgrtgaicaidytwnllkagkipeefnvfnliqemrtqrhsavqtkeqyelvhraiaqlfe|GenPept| obj|String*|1|NP_002826 end||3-JUL-2003|\21:Homo sapiens (human). obj|String*|0 end|0 obj|String*|0 end|PRT obj|String*|0 end obj|String*|1|Homo sapiens end obj|String*|0 end obj|String*|0 end obj|String*|12|Eukaryota|Metazoa|Chordata|Craniata|Vertebrata|Euteleostomi|Mammalia|Eutheria|Primates|Catarrhini|Hominidae|Homo end obj|Object*|0 end obj|String*|0 end obj|String*|0 end obj|String*|1|\29:REFSEQ: accession NM_002835.2 end obj|String*|8|\53:VNTI URL:vnti:protein/hPEST_D1+%28NP_002826%29+PTPN12|\53:VNTI URL:vnti:protein/hPEST_D1+%28NP_002826%29+PTPN12|\53:VNTI URL:vnti:protein/hPEST_D1+%28NP_002826%29+PTPN12|\53:VNTI URL:vnti:protein/hPEST_D1+%28NP_002826%29+PTPN12|\53:VNTI URL:vnti:protein/hPEST_D1+%28NP_002826%29+PTPN12|\53:VNTI URL:vnti:protein/hPEST_D1+%28NP_002826%29+PTPN12|\53:VNTI URL:vnti:protein/hPEST_D1+%28NP_002826%29+PTPN12|\53:VNTI URL:vnti:protein/hPEST_D1+%28NP_002826%29+PTPN12 end obj|String*|0 end obj|String*|0 end end|1014FF0 end obj|IxMolX obj|Molecule obj|BioObject obj|DBObj||\27:hPTP1B_D1 (NP_002818) PTPN1|||||302014800|0|\173:protein tyrosine phosphatase, non-receptor type 1; non-receptor tyrosine phophatase 1; protein tyrosine phophatase 1B; protein tyrosine phophatase, placental [Homo sapiens]. end|2|2| obj|String*|0 end obj|String*|18|\64:REVIEWED REFSEQ: This record has been curated by NCBI staff. The|\60:reference sequence was derived from M33689.1 and AU117677.1.||\67:Summary: The protein encoded by this gene is the founding member of|\65:the protein tyrosine phosphatase (PTP) family, which was isolated|\61:and identified based on its enzymatic activity and amino acid|\66:sequence. PTPs catalyze the hydrolysis of the phosphate monoesters|\66:specifically on tyrosine residues. Members of the PTP family share|\62:a highly conserved catalytic motif, which is essential for the|\65:catalytic activity. PTPs are known to be signaling molecules that|\63:regulate a variety of cellular processes including cell growth,|\66:differentiation, mitotic cycle, and oncogenic transformation. This|\60:PTP has been shown to act as a negative regulator of insulin|\62:signaling by dephosphorylating the phosphotryosine residues of|\54:insulin receptor kinase. This PTP was also reported to|\67:dephosphorylate epidermal growth factor receptor kinase, as well as|\63:JAK2 and TYK2 kinases, which implicated the role of this PTP in|\65:cell growth control, and cell response to interferon stimulation. end obj|String*|115|\34:REFERENCE 1 (residues 1 to 435)|\34: AUTHORS Li,S. and Whorton,A.R.|\76: TITLE Regulation of protein tyrosine phosphatase 1B in intact cells by|\27: S-nitrosothiols|\59: JOURNAL Arch. Biochem. Biophys. 410 (2), 269-279 (2003)| MEDLINE 22461115|\79: REMARK GeneRIF: PTP1B inhibition by S-nitrosylation is caused by formation|\32: of a mixed disulfide|\34:REFERENCE 2 (residues 1 to 435)|\36: AUTHORS Fukada,T. and Tonks,N.K.|\70: TITLE Identification of YB-1 as a regulator of PTP1B expression:|\73: implications for regulation of insulin and cytokine signaling|\42: JOURNAL EMBO J. 22 (3), 479-493 (2003)| MEDLINE 22441887|\71: REMARK GeneRIF: Data show that Y box-binding protein-1 (YB-1) is a|\76: regulator of protein tyrosine phosphatase 1B (PTP1B) expression,|\71: and highlight PTP1B as a critical regulator of insulin- and|\50: cytokine-mediated signal transduction.|\34:REFERENCE 3 (residues 1 to 435)|\77: AUTHORS Yigzaw,Y., Poppleton,H.M., Sreejayan,N., Hassid,A. and Patel,T.B.|\79: TITLE Protein-tyrosine phosphatase-1B (PTP1B) mediates the anti-migratory|\30: actions of Sprouty|\50: JOURNAL J. Biol. Chem. 278 (1), 284-288 (2003)| MEDLINE 22393490|\75: REMARK GeneRIF: Data show that an increase in soluble protein-tyrosine|\78: phosphatase 1B activity contributes to the anti-migratory, but not|\55: anti-mitogenic, actions of human Sprouty 2.|\34:REFERENCE 4 (residues 1 to 435)|\73: AUTHORS Di Paola,R., Frittitta,L., Miscio,G., Bozzali,M., Baratta,R.,|\66: Centra,M., Spampinato,D., Santagati,M.G., Ercolino,T.,|\75: Cisternino,C., Soccio,T., Mastroianno,S., Tassi,V., Almgren,P.,|\52: Pizzuti,A., Vigneri,R. and Trischitta,V.|\78: TITLE A variation in 3' UTR of hPTP1B increases specific gene expression|\50: and associates with insulin resistance|\53: JOURNAL Am. J. Hum. Genet. 70 (3), 806-812 (2002)| MEDLINE 21832513|\74: REMARK GeneRIF: variation in 3' UTR of hPTP1B increases specific gene|\61: expression and associates with insulin resistance|\34:REFERENCE 5 (residues 1 to 435)|\77: AUTHORS Myers,M.P., Andersen,J.N., Cheng,A., Tremblay,M.L., Horvath,C.M.,|\64: Parisien,J.P., Salmeen,A., Barford,D. and Tonks,N.K.|\75: TITLE TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B|\55: JOURNAL J. Biol. Chem. 276 (51), 47771-47774 (2001)| MEDLINE 21611285|\34:REFERENCE 6 (residues 1 to 435)|\58: AUTHORS Wang,J., Cheung,A.T., Kolls,J.K., Starks,W.W.,|\62: Martinez-Hernandez,A., Dietzen,D. and Bryer-Ash,M.|\76: TITLE Effects of adenovirus-mediated liver-selective overexpression of|\74: protein tyrosine phosphatase-1b on insulin sensitivity in vivo|\53: JOURNAL Diabetes Obes Metab 3 (5), 367-380 (2001)| MEDLINE 21560532|\78: REMARK GeneRIF: Moderate overabundance of PTP-1B in liver tissue does not|\78: alter insulin action on glucose metabolism, and the site of action|\74: of PTP-1B is presumably at insulin-responsive target tissue or|\41: tissues other than the liver.|\34:REFERENCE 7 (residues 1 to 435)|\45: AUTHORS Dadke,S., Kusari,A. and Kusari,J.|\74: TITLE Phosphorylation and activation of protein tyrosine phosphatase|\40: (PTP) 1B by insulin receptor|\57: JOURNAL Mol. Cell. Biochem. 221 (1-2), 147-154 (2001)| MEDLINE 21396990|\34:REFERENCE 8 (residues 1 to 435)|\67: AUTHORS Egawa,K., Maegawa,H., Shimizu,S., Morino,K., Nishio,Y.,|\78: Bryer-Ash,M., Cheung,A.T., Kolls,J.K., Kikkawa,R. and Kashiwagi,A.|\72: TITLE Protein-tyrosine phosphatase-1B negatively regulates insulin|\59: signaling in l6 myocytes and Fao hepatoma cells|\55: JOURNAL J. Biol. Chem. 276 (13), 10207-10211 (2001)| MEDLINE 21167830|\34:REFERENCE 9 (residues 1 to 435)|\76: AUTHORS Salmeen,A., Andersen,J.N., Myers,M.P., Tonks,N.K. and Barford,D.|\79: TITLE Molecular basis for the dephosphorylation of the activation segment|\70: of the insulin receptor by protein tyrosine phosphatase 1B|\45: JOURNAL Mol. Cell 6 (6), 1401-1412 (2000)| MEDLINE 21111049|\34:REFERENCE 10 (residues 1 to 435)|\65: AUTHORS Peters,G.H., Iversen,L.F., Branner,S., Andersen,H.S.,|\67: Mortensen,S.B., Olsen,O.H., Moller,K.B. and Moller,N.P.|\72: TITLE Residue 259 is a key determinant of substrate specificity of|\54: protein-tyrosine phosphatases 1B and alpha|\55: JOURNAL J. Biol. Chem. 275 (24), 18201-18209 (2000)| MEDLINE 20309769|\34:REFERENCE 11 (residues 1 to 435)|\64: AUTHORS Ahmad,F., Li,P.M., Meyerovitch,J. and Goldstein,B.J.|\78: TITLE Osmotic loading of neutralizing antibodies demonstrates a role for|\73: protein-tyrosine phosphatase 1B in negative regulation of the|\34: insulin action pathway|\55: JOURNAL J. Biol. Chem. 270 (35), 20503-20508 (1995)| MEDLINE 95386495|\34:REFERENCE 12 (residues 1 to 435)|\76: AUTHORS Milarski,K.L., Zhu,G., Pearl,C.G., McNamara,D.J., Dobrusin,E.M.,|\79: MacLean,D., Thieme-Sefler,A., Zhang,Z.Y., Sawyer,T., Decker,S.J. et| al.|\78: TITLE Sequence specificity in recognition of the epidermal growth factor|\55: receptor by protein tyrosine phosphatase 1B|\55: JOURNAL J. Biol. Chem. 268 (31), 23634-23639 (1993)| MEDLINE 94043167|\34:REFERENCE 13 (residues 1 to 435)|\69: AUTHORS Brown-Shimer,S., Johnson,K.A., Lawrence,J.B., Johnson,C.,|\48: Bruskin,A., Green,N.R. and Hill,D.E.|\79: TITLE Molecular cloning and chromosome mapping of the human gene encoding|\49: protein phosphotyrosyl phosphatase 1B|\67: JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (13), 5148-5152 (1990)| MEDLINE 90311360|\34:REFERENCE 14 (residues 1 to 435)|\79: AUTHORS Chernoff,J., Schievella,A.R., Jost,C.A., Erikson,R.L. and Neel,B.G.|\76: TITLE Cloning of a cDNA for a major human protein-tyrosine-phosphatase|\66: JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (7), 2735-2739 (1990)| MEDLINE 90207272|\34:REFERENCE 15 (residues 1 to 435)|\75: AUTHORS Charbonneau,H., Tonks,N.K., Kumar,S., Diltz,C.D., Harrylock,M.,|\62: Cool,D.E., Krebs,E.G., Fischer,E.H. and Walsh,K.A.|\76: TITLE Human placenta protein-tyrosine-phosphatase: amino acid sequence|\66: and relationship to a family of receptor-like proteins|\67: JOURNAL Proc. Natl. Acad. Sci. U.S.A. 86 (14), 5252-5256 (1989)| MEDLINE 89315775 end obj|Object*|0 end obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp end obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/ end end|1|0|279 obj|Object*|3 obj|Feature obj|DBObj||Source_1|||||0|0| end|269|269|||0|1|279|1|1|1|1|1..279 obj|String*|4|\24:/organism="Homo sapiens"|\21:/db_xref="taxon:9606"|/chromosome="20"|/map="20q13.1-q13.2" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Protein_1|||||0|0|\106:non-receptor tyrosine phophatase 1; protein tyrosine phophatase 1B; protein tyrosine phophatase, placental end|270|270|||0|1|279|1|1|1|1|1..279 obj|String*|3|\57:/product="protein tyrosine phosphatase, non-receptor type|1"|\21:/EC_number="3.1.3.48" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Region_1|||||0|0|PTPc end|266|266|||0|3|279|1|1|1|1|3..279 obj|String*|3|\53:/region_name="Protein tyrosine phosphatase, catalytic|domain"|\25:/db_xref="CDD:smart00194" end|0|| obj|Object*|0 end end end|\279:memekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrdvspfdhsriklhqedndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvvmlnrvmekgslkcaqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqetreilhfhyttwpdfgvpespasflnflfkvresgslspehgpvvvhcsagigrsgtfcladtclllmdkrkdpssvdikkvllemrkfrmgliqtadqlrfsylaviegak|GenPept| obj|String*|1|NP_002818 end||17-MAY-2003|\21:Homo sapiens (human). obj|String*|0 end|0 obj|String*|0 end|PRT obj|String*|0 end obj|String*|1|Homo sapiens end obj|String*|0 end obj|String*|0 end obj|String*|12|Eukaryota|Metazoa|Chordata|Craniata|Vertebrata|Euteleostomi|Mammalia|Eutheria|Primates|Catarrhini|Hominidae|Homo end obj|Object*|0 end obj|String*|0 end obj|String*|0 end obj|String*|1|\29:REFSEQ: accession NM_002827.2 end obj|String*|21|\53:VNTI URL:vnti:protein/hPTP1B_D1+%28NP_002818%29+PTPN1|\53:VNTI URL:vnti:protein/hPTP1B_D1+%28NP_002818%29+PTPN1|\53:VNTI URL:vnti:protein/hPTP1B_D1+%28NP_002818%29+PTPN1|\53:VNTI URL:vnti:protein/hPTP1B_D1+%28NP_002818%29+PTPN1|\53:VNTI URL:vnti:protein/hPTP1B_D1+%28NP_002818%29+PTPN1|\53:VNTI URL:vnti:protein/hPTP1B_D1+%28NP_002818%29+PTPN1|\53:VNTI URL:vnti:protein/hPTP1B_D1+%28NP_002818%29+PTPN1|\53:VNTI URL:vnti:protein/hPTP1B_D1+%28NP_002818%29+PTPN1|\53:VNTI URL:vnti:protein/hPTP1B_D1+%28NP_002818%29+PTPN1|\53:VNTI URL:vnti:protein/hPTP1B_D1+%28NP_002818%29+PTPN1|\53:VNTI URL:vnti:protein/hPTP1B_D1+%28NP_002818%29+PTPN1|\53:VNTI URL:vnti:protein/hPTP1B_D1+%28NP_002818%29+PTPN1|\53:VNTI URL:vnti:protein/hPTP1B_D1+%28NP_002818%29+PTPN1|\53:VNTI URL:vnti:protein/hPTP1B_D1+%28NP_002818%29+PTPN1|\53:VNTI URL:vnti:protein/hPTP1B_D1+%28NP_002818%29+PTPN1|\53:VNTI URL:vnti:protein/hPTP1B_D1+%28NP_002818%29+PTPN1|\53:VNTI URL:vnti:protein/hPTP1B_D1+%28NP_002818%29+PTPN1|\53:VNTI URL:vnti:protein/hPTP1B_D1+%28NP_002818%29+PTPN1|\53:VNTI URL:vnti:protein/hPTP1B_D1+%28NP_002818%29+PTPN1|\53:VNTI URL:vnti:protein/hPTP1B_D1+%28NP_002818%29+PTPN1|\53:VNTI URL:vnti:protein/hPTP1B_D1+%28NP_002818%29+PTPN1 end obj|String*|0 end obj|String*|0 end end|FCA030 end obj|IxMolX obj|Molecule obj|BioObject obj|DBObj||\30:hPTPalpha_D1 (NP_002827) PTPRA|||||302014800|0|\287:protein tyrosine phosphatase, receptor type, A isoform 1 precursor; protein tyrosine phosphatase, receptor type, alpha polypeptide; PTPase-alpha; Leukocyte common antigen-related peptide (protein tyrosine phosphate); tyrosine phosphatase alpha; PTPLCA-related phosphatase [Homo sapiens]. end|2|2| obj|String*|0 end obj|String*|22|\64:REVIEWED REFSEQ: This record has been curated by NCBI staff. The|\60:reference sequence was derived from M34668.1 and AI284972.1.||\60:Summary: The protein encoded by this gene is a member of the|\63:protein tyrosine phosphatase (PTP) family. PTPs are known to be|\65:signaling molecules that regulate a variety of cellular processes|\58:including cell growth, differentiation, mitotic cycle, and|\60:oncogenic transformation. This PTP contains an extracellular|\53:domain, a single transmembrane segment and two tandem|\57:intracytoplasmic catalytic domains, and thus represents a|\65:receptor-type PTP. This PTP has been shown to dephosphorylate and|\62:activate Src family tyrosine kinases, and is implicated in the|\66:regulation of integrin signaling, cell adhesion and proliferation.|\67:Three alternatively spliced variants of this gene, which encode two|\38:distinct isoforms, have been reported.||\61:Transcript Variant: This variant (1) contains a unique 5' UTR|\65:region when compared to other variants. The genomic exons forming|\61:the 5' end region of this transcript are also used to form an|\67:internal coding region in the transcripts of VPS16, a distinct gene|\57:located at the locus immediately upstream of this gene on|\60:chromosome 20. This variant encodes the longest isoform (1). end obj|String*|86|\34:REFERENCE 1 (residues 1 to 802)|\74: AUTHORS Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J.|\72: TITLE Intra- and intermolecular interactions between intracellular|\61: domains of receptor protein-tyrosine phosphatases|\55: JOURNAL J. Biol. Chem. 277 (49), 47263-47269 (2002)| MEDLINE 22344739|\78: REMARK GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are|\75: a common but specific mechanism that is likely to be regulated-|\73: domain2s and the wedge structures are crucial determinants of|\73: binding specificity, thus regulating cross-talk between RPTPs|\34:REFERENCE 2 (residues 1 to 802)|\37: AUTHORS Mustelin,T. and Hunter,T.|\74: TITLE Meeting at mitosis: cell cycle-specific regulation of c-Src by|\21: RPTPalpha|\43: JOURNAL Sci STKE 2002 (115), PE3 (2002)| MEDLINE 21655780|\78: REMARK GeneRIF: In entering mitosis the cell cycle-specific regulation of|\79: c-Src by RPTPalpha can occur by dephosphorylation of phospho-Tyr527|\77: that activates c-Src in a reaction catalyzed by the transmembrane|\65: receptor-like protein tyrosine phosphatase RPTPalpha.|\34:REFERENCE 3 (residues 1 to 802)|\69: AUTHORS Ardini,E., Agresti,R., Tagliabue,E., Greco,M., Aiello,P.,|\43: Yang,L.T., Menard,S. and Sap,J.|\75: TITLE Expression of protein tyrosine phosphatase alpha (RPTPalpha) in|\77: human breast cancer correlates with low tumor grade, and inhibits|\50: tumor cell growth in vitro and in vivo|\46: JOURNAL Oncogene 19 (43), 4979-4987 (2000)| MEDLINE 20499263|\34:REFERENCE 4 (residues 1 to 802)|\65: AUTHORS Peters,G.H., Iversen,L.F., Branner,S., Andersen,H.S.,|\67: Mortensen,S.B., Olsen,O.H., Moller,K.B. and Moller,N.P.|\72: TITLE Residue 259 is a key determinant of substrate specificity of|\54: protein-tyrosine phosphatases 1B and alpha|\55: JOURNAL J. Biol. Chem. 275 (24), 18201-18209 (2000)| MEDLINE 20309769|\34:REFERENCE 5 (residues 1 to 802)|\65: AUTHORS Harder,K.W., Moller,N.P., Peacock,J.W. and Jirik,F.R.|\79: TITLE Protein-tyrosine phosphatase alpha regulates Src family kinases and|\43: alters cell-substratum adhesion|\55: JOURNAL J. Biol. Chem. 273 (48), 31890-31900 (1998)| MEDLINE 99041953|\34:REFERENCE 6 (residues 1 to 802)|\47: AUTHORS Zheng,X.M., Wang,Y. and Pallen,C.J.|\77: TITLE Cell transformation and activation of pp60c-src by overexpression|\45: of a protein tyrosine phosphatase|\45: JOURNAL Nature 359 (6393), 336-339 (1992)| MEDLINE 93024881|\34:REFERENCE 7 (residues 1 to 802)|\73: AUTHORS Rao,V.V., Loffler,C., Sap,J., Schlessinger,J. and Hansmann,I.|\79: TITLE The gene for receptor-linked protein-tyrosine-phosphatase (PTPA) is|\76: assigned to human chromosome 20p12-pter by in situ hybridization|\26: (ISH and FISH)|\43: JOURNAL Genomics 13 (3), 906-907 (1992)| MEDLINE 92347910|\34:REFERENCE 8 (residues 1 to 802)|\47: AUTHORS Ohagi,S., Nishi,M. and Steiner,D.F.|\67: TITLE Sequence of a cDNA encoding human LRP (leukocyte common|\36: antigen-related peptide)|\51: JOURNAL Nucleic Acids Res. 18 (23), 7159 (1990)| MEDLINE 91088320|\34:REFERENCE 9 (residues 1 to 802)|\65: AUTHORS Jirik,F.R., Janzen,N.M., Melhado,I.G. and Harder,K.W.|\74: TITLE Cloning and chromosomal assignment of a widely expressed human|\54: receptor-like protein-tyrosine phosphatase|\48: JOURNAL FEBS Lett. 273 (1-2), 239-242 (1990)| MEDLINE 91032191|\34:REFERENCE 10 (residues 1 to 802)|\49: AUTHORS Krueger,N.X., Streuli,M. and Saito,H.|\77: TITLE Structural diversity and evolution of human receptor-like protein|\33: tyrosine phosphatases|\44: JOURNAL EMBO J. 9 (10), 3241-3252 (1990)| MEDLINE 91006018|\34:REFERENCE 11 (residues 1 to 802)|\74: AUTHORS Kaplan,R., Morse,B., Huebner,K., Croce,C., Howk,R., Ravera,M.,|\49: Ricca,G., Jaye,M. and Schlessinger,J.|\76: TITLE Cloning of three human tyrosine phosphatases reveals a multigene|\77: family of receptor-linked protein-tyrosine-phosphatases expressed| in brain|\67: JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (18), 7000-7004 (1990)| MEDLINE 90384936|\34:REFERENCE 12 (residues 1 to 802)|\64: AUTHORS Sap,J., D'Eustachio,P., Givol,D. and Schlessinger,J.|\74: TITLE Cloning and expression of a widely expressed receptor tyrosine|\23: phosphatase|\67: JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (16), 6112-6116 (1990)| MEDLINE 90349565 end obj|Object*|0 end obj|CreatorData|||||\28:jannik@noergaardandersen.com|||Jannik N Andersen||\56:http://ptp.cshl.edu & http://science.novonordisk.com/ptp end obj|CreatorData|\45:National Center for Biotechnology Information|\28:National Library of Medicine|\24:Building 38A, Room 8N805|\26:Bethesda, MD 20894, U.S.A.|\21:info@ncbi.nlm.nih.gov|(301)480-9241||NCBI Entrez|(301)496-2475|\36:http://www3.ncbi.nlm.nih.gov/Entrez/ end end|1|0|280 obj|Object*|4 obj|Feature obj|DBObj||Source_1|||||0|0| end|269|269|||0|1|280|1|1|1|1|1..280 obj|String*|4|\24:/organism="Homo sapiens"|\21:/db_xref="taxon:9606"|/chromosome="20"|/map="20p13" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Protein_1|||||0|0|\203:protein tyrosine phosphatase, receptor type, alpha polypeptide; PTPase-alpha; Leukocyte common antigen-related peptide (protein tyrosine phosphate); tyrosine phosphatase alpha; PTPLCA-related phosphatase end|270|270|||0|1|280|1|1|1|1|1..280 obj|String*|3|\56:/product="protein tyrosine phosphatase, receptor type, A|isoform 1 precursor"|\21:/EC_number="3.1.3.48" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Chain_1|||||0|0| end|203|203|||0|1|280|1|1|1|1|1..280 obj|String*|2|\57:/product="protein tyrosine phosphatase, receptor type, A,|isoform 1" end|0|| obj|Object*|0 end end obj|Feature obj|DBObj||Region_1|||||0|0|PTPc end|266|266|||0|17|280|1|1|1|1|17..280 obj|String*|3|\53:/region_name="Protein tyrosine phosphatase, catalytic|domain"|\25:/db_xref="CDD:smart00194" end|0|| obj|Object*|0 end end end|\280:dkleeeinrrmaddnklfreefnalpacpiqatceaaskeenkeknryvnilpydhsrvhltpvegvpdsdyinasfingyqeknkfiaaqgpkeetvndfwrmiweqntativmvtnlkerkeckcaqywpdqgcwtygnirvsvedvtvlvdytvrkfciqqvgdmtnrkpqrlitqfhftswpdfgvpftpigmlkflkkvkacnpqyagaivvhcsagvgrtgtfvvidamldmmhterkvdvygfvsriraqrcqmvqtdmqyvfiyqallehyl|GenPept| obj|String*|1|NP_002827 end||17-MAY-2003|\21:Homo sapiens (human). obj|String*|0 end|0 obj|String*|0 end|PRT obj|String*|0 end obj|String*|1|Homo sapiens end obj|String*|0 end obj|String*|0 end obj|String*|12|Eukaryota|Metazoa|Chordata|Craniata|Vertebrata|Euteleostomi|Mammalia|Eutheria|Primates|Catarrhini|Hominidae|Homo end obj|Object*|0 end obj|String*|0 end obj|String*|0 end obj|String*|1|\29:REFSEQ: accession NM_002836.2 end obj|String*|21|\56:VNTI URL:vnti:protein/hPTPalpha_D1+%28NP_002827%29+PTPRA|\56:VNTI URL:vnti:protein/hPTPalpha_D1+%28NP_002827%29+PTPRA|\56:VNTI URL:vnti:protein/hPTPalpha_D1+%28NP_002827%29+PTPRA|\56:VNTI URL:vnti:protein/hPTPalpha_D1+%28NP_002827%29+PTPRA|\56:VNTI URL:vnti:protein/hPTPalpha_D1+%28NP_002827%29+PTPRA|\56:VNTI URL:vnti:protein/hPTPalpha_D1+%28NP_002827%29+PTPRA|\56:VNTI URL:vnti:protein/hPTPalpha_D1+%28NP_002827%29+PTPRA|\56:VNTI URL:vnti:protein/hPTPalpha_D1+%28NP_002827%29+PTPRA|\56:VNTI URL:vnti:protein/hPTPalpha_D1+%28NP_002827%29+PTPRA|\56:VNTI URL:vnti:protein/hPTPalpha_D1+%28NP_002827%29+PTPRA|\56:VNTI URL:vnti:protein/hPTPalpha_D1+%28NP_002827%29+PTPRA|\56:VNTI URL:vnti:protein/hPTPalpha_D1+%28NP_002827%29+PTPRA|\56:VNTI URL:vnti:protein/hPTPalpha_D1+%28NP_002827%29+PTPRA|\56:VNTI URL:vnti:protein/hPTPalpha_D1+%28NP_002827%29+PTPRA|\56:VNTI URL:vnti:protein/hPTPalpha_D1+%28NP_002827%29+PTPRA|\56:VNTI URL:vnti:protein/hPTPalpha_D1+%28NP_002827%29+PTPRA|\56:VNTI URL:vnti:protein/hPTPalpha_D1+%28NP_002827%29+PTPRA|\56:VNTI URL:vnti:protein/hPTPalpha_D1+%28NP_002827%29+PTPRA|\56:VNTI URL:vnti:protein/hPTPalpha_D1+%28NP_002827%29+PTPRA|\56:VNTI URL:vnti:protein/hPTPalpha_D1+%28NP_002827%29+PTPRA|\56:VNTI URL:vnti:protein/hPTPalpha_D1+%28NP_002827%29+PTPRA end obj|String*|0 end obj|String*|0 end end|FCFE28 end obj|IxMolX obj|Molecule obj|BioObject obj|DBObj||\29:hPTPBAS_D1 (NP_006255) PTPN13|||||302014800|0|\314:protein tyrosine phosphatase, non-receptor type 13 isoform 2; protein tyrosine phosphatase, nonreceptor type 13; protein tyrosine phosphatase 1E; Fas-associated phosphatase-1; protein-tyrosine phosphatase 1, Fas-associated; protein-tyrosine phophatase PTPL1; APO-1/CD95 (Fas)-associated phosphatase [Homo sapiens]. end|2|2| obj|String*|0 end obj|String*|24|\64:REVIEWED REFSEQ: This record has been curated by NCBI staff. The|\45:reference sequence was derived from D21210.1.||\60:Summary: The protein encoded by this gene is a member of the|\63:protein tyrosine phosphatase (PTP) family. PTPs are known to be|\65:signaling molecules that regulate a variety of cellular processes|\58:including cell growth, differentiation, mitotic cycle, and|\58:oncogenic transformation. This PTP is a large protein that|\63:possesses a PTP domain at C-terminus, and multiple noncatalytic|\59:domains, which include a domain with similarity to band 4.1|\57:superfamily of cytoskeletal-associated proteins, a region|\64:consisting of five PDZ domains, and a leucine zipper motif. This|\65:PTP was found to interact with, and dephosphorylate Fas receptor,|\64:as well as IkappaBalpha through the PDZ domains, which suggested|\65:its role in Fas mediated programmed cell death. This PTP was also|\62:shown to interact with GTPase-activating protein, and thus may|\54:function as a regulator of Rho signaling pathway. Four|\64:alternatively spliced transcript variants, which encode distinct|\29:proteins, have been reported.||\63:Transcript Variant: This variant (2) lacks an internal fragment|\56:within the coding region when compared to variant 4. The|\59:translation remains in frame, and the encoded protein lacks|\41:internal 19 aa, as compared to isoform 4. end obj|String*|122|\35:REFERENCE 1 (residues 1 to 2466)|\78: AUTHORS Yoshida,S., Harada,H., Nagai,H., Fukino,K., Teramoto,A. and Emi,M.|\78: TITLE Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1)|\79: and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and|\49: seven polymorphisms of the FAP-1 gene|\50: JOURNAL J. Hum. Genet. 47 (11), 614-619 (2002)| MEDLINE 22323362|\74: REMARK GeneRIF: Shares a promoter region with the tightly linked gene|\58: encoding stress-activated protein kinase JNK3.|\35:REFERENCE 2 (residues 1 to 2466)|\69: AUTHORS Bompard,G., Puech,C., Prebois,C., Vignon,F. and Freiss,G.|\74: TITLE Protein-tyrosine phosphatase PTPL1/FAP-1 triggers apoptosis in|\37: human breast cancer cells|\55: JOURNAL J. Biol. Chem. 277 (49), 47861-47869 (2002)| MEDLINE 22344658|\75: REMARK GeneRIF: PTPL1/FAP-1 has a key role in the apoptotic process in|\79: human breast cancer cells independent of Fas but associated with an|\52: early inhibition of the insulin receptor|\61: substrate-1/phosphatidylinositol 3-kinase pathway|\35:REFERENCE 3 (residues 1 to 2466)|\59: AUTHORS Kozlov,G., Banville,D., Gehring,K. and Ekiel,I.|\70: TITLE Solution structure of the PDZ2 domain from cytosolic human|\79: phosphatase hPTP1E complexed with a peptide reveals contribution of|\66: the beta2-beta3 loop to PDZ domain-ligand interactions|\49: JOURNAL J. Mol. Biol. 320 (4), 813-820 (2002)| MEDLINE 22090786|\72: REMARK GeneRIF: PDZ2 domain from cytosolic human phosphatase hPTP1E|\73: complexed with peptide, RA-GEF-2, reveals contribution of the|\62: beta2-beta3 loop to PDZ domain-ligand interactions|\35:REFERENCE 4 (residues 1 to 2466)|\69: AUTHORS Walma,T., Spronk,C.A., Tessari,M., Aelen,J., Schepens,J.,|\40: Hendriks,W. and Vuister,G.W.|\77: TITLE Structure, dynamics and binding characteristics of the second PDZ|\28: domain of PTP-BL|\51: JOURNAL J. Mol. Biol. 316 (5), 1101-1110 (2002)| MEDLINE 21881810|\75: REMARK GeneRIF: Structure, dynamics and binding characteristics of the|\39: second PDZ domain of PTP-BL|\35:REFERENCE 5 (residues 1 to 2466)|\71: AUTHORS Marin,L., Minguela,A., Moya-Quiles,M.R., Torio,A., Muro,M.,|\73: Garcia-Alonso,A.M., Sanchez-Bueno,F., Bru,M., Parrilla,P. and|\30: Alvarez-Lopez,M.R.|\74: TITLE Expression of CD95 and apoptosis induction in peripheral blood|\45: cells from liver graft recipients|\52: JOURNAL Transplant. Proc. 34 (1), 280-282 (2002)| MEDLINE 21957524|\75: REMARK GeneRIF: expression and apoptosis induction in peripheral blood|\34: cells from liver graft|\35:REFERENCE 6 (residues 1 to 2466)|\43: AUTHORS Nakai,Y., Irie,S. and Sato,T.A.|\75: TITLE Identification of IkappaBalpha as a substrate of Fas-associated|\25: phosphatase-1|\55: JOURNAL Eur. J. Biochem. 267 (24), 7170-7175 (2000)| MEDLINE 20558254|\35:REFERENCE 7 (residues 1 to 2466)|\76: AUTHORS Irie,S., Hachiya,T., Rabizadeh,S., Maruyama,W., Mukai,J., Li,Y.,|\50: Reed,J.C., Bredesen,D.E. and Sato,T.A.|\79: TITLE Functional interaction of Fas-associated phosphatase-1 (FAP-1) with|\61: p75(NTR) and their effect on NF-kappaB activation|\46: JOURNAL FEBS Lett. 460 (2), 191-198 (1999)| MEDLINE 20012928|\35:REFERENCE 8 (residues 1 to 2466)|\70: AUTHORS Maekawa,K., Imagawa,N., Naito,A., Harada,S., Yoshie,O. and|\21: Takagi,S.|\72: TITLE Association of protein-tyrosine phosphatase PTP-BAS with the|\72: transcription-factor-inhibitory protein IkappaBalpha through|\67: interaction between the PDZ1 domain and ankyrin repeats|\50: JOURNAL Biochem. J. 337 (Pt 2), 179-184 (1999)| MEDLINE 99102074|\35:REFERENCE 9 (residues 1 to 2466)|\75: AUTHORS Saras,J., Franzen,P., Aspenstrom,P., Hellman,U., Gonez,L.J. and|\23: Heldin,C.H.|\74: TITLE A novel GTPase-activating protein for Rho interacts with a PDZ|\60: domain of the protein-tyrosine phosphatase PTPL1|\55: JOURNAL J. Biol. Chem. 272 (39), 24333-24338 (1997)| MEDLINE 97450957|\35:REFERENCE 10 (residues 1 to 2466)|\61: AUTHORS Saras,J., Engstrom,U., Gonez,L.J. and Heldin,C.H.|\75: TITLE Characterization of the interactions between PDZ domains of the|\77: protein-tyrosine phosphatase PTPL1 and the carboxyl-terminal tail| of Fas|\55: JOURNAL J. Biol. Chem. 272 (34), 20979-20981 (1997)| MEDLINE 97407871|\35:REFERENCE 11 (residues 1 to 2466)|\70: