ID   hCD45_D2\(NP_002829)\PTPRC STANDARD;PRT;   308 AA.
AC   NP_002829;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, C isoform 1 precursor; protein tyrosine phosphatase, receptor type, c polypeptide; leukocyte-common antigen; T200 glycoprotein; human homolog of severe combined immunodeficiency due to PTPRC deficiency; SCID due to PTPRC deficiency; CD45 antigen [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from Y00638.1 and Y00062.1.
CC   On Feb 8, 2002 this sequence version replaced gi:4506307.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP contains an extracellular
CC   domain, a single transmembrane segment and two tandem
CC   intracytoplasmic catalytic domains, and thus belongs to receptor
CC   type PTP. This gene is specifically expressed in hematopoietic
CC   cells. This PTP has been shown to be an essential regulator of T-
CC   and B-cell antigen receptor signaling. It functions through either
CC   direct interaction with components of the antigen receptor
CC   complexes, or by activating various Src family kinases required for
CC   the antigen receptor signaling. This PTP also suppresses JAK
CC   kinases, and thus functions as a regulator of cytokine receptor
CC   signaling. Four alternatively spliced transcripts variants of this
CC   gene, which encode distinct isoforms, have been reported.
CC   
CC   Transcript Variant: This variant (1) encodes the longest isoform
CC   (1).
CC   GPRFLN|REFERENCE   1  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Baldwin,T.A. and Ostergaard,H.L.
CC   GPRFLN|  TITLE     The protein-tyrosine phosphatase CD45 reaches the cell surface via
CC   GPRFLN|            golgi-dependent and -independent pathways
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (52), 50333-50340 (2002)
CC   GPRFLN|  MEDLINE   22384317
CC   GPRFLN|  REMARK    GeneRIF: reaches the cell surface via Golgi-dependent and
CC   GPRFLN|            -independent pathways
CC   GPRFLN|REFERENCE   2  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Harashima,A., Suzuki,M., Okochi,A., Yamamoto,M., Matsuo,Y.,
CC   GPRFLN|            Motoda,R., Yoshioka,T. and Orita,K.
CC   GPRFLN|  TITLE     CD45 tyrosine phosphatase inhibits erythroid differentiation of
CC   GPRFLN|            umbilical cord blood CD34+ cells associated with selective
CC   GPRFLN|            inactivation of Lyn
CC   GPRFLN|  JOURNAL   Blood 100 (13), 4440-4445 (2002)
CC   GPRFLN|  MEDLINE   22340750
CC   GPRFLN|  REMARK    GeneRIF: CD45 may play a pivotal role in erythropoiesis. CD45
CC   GPRFLN|            tyrosine phosphatase inhibits erythroid differentiation of
CC   GPRFLN|            umbilical cord blood CD34+ cells associated with selective
CC   GPRFLN|            inactivation of Lyn.
CC   GPRFLN|REFERENCE   3  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J.
CC   GPRFLN|  TITLE     Intra- and intermolecular interactions between intracellular
CC   GPRFLN|            domains of receptor protein-tyrosine phosphatases
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (49), 47263-47269 (2002)
CC   GPRFLN|  MEDLINE   22344739
CC   GPRFLN|  REMARK    GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are
CC   GPRFLN|            a common but specific mechanism that is likely to be regulated-
CC   GPRFLN|            domain2s and the wedge structures are crucial determinants of
CC   GPRFLN|            binding specificity, thus regulating cross-talk between RPTPs
CC   GPRFLN|REFERENCE   4  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Pradhan,D. and Morrow,J.
CC   GPRFLN|  TITLE     The spectrin-ankyrin skeleton controls CD45 surface display and
CC   GPRFLN|            interleukin-2 production
CC   GPRFLN|  JOURNAL   Immunity 17 (3), 303-315 (2002)
CC   GPRFLN|  MEDLINE   22241694
CC   GPRFLN|  REMARK    GeneRIF: The spectrin-ankyrin skeleton controls CD45 surface
CC   GPRFLN|            display and interleukin-2 production.
CC   GPRFLN|REFERENCE   5  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Ballerini,C., Rosati,E., Salvetti,M., Ristori,G., Cannoni,S.,
CC   GPRFLN|            Biagioli,T., Massacesi,L., Sorbi,S. and Vergelli,M.
CC   GPRFLN|  TITLE     Protein tyrosine phosphatase receptor-type C exon 4 gene mutation
CC   GPRFLN|            distribution in an Italian multiple sclerosis population
CC   GPRFLN|  JOURNAL   Neurosci. Lett. 328 (3), 325-327 (2002)
CC   GPRFLN|  MEDLINE   22142931
CC   GPRFLN|  REMARK    GeneRIF: Role of the C-->G mutation in position 77 of exon 4 of the
CC   GPRFLN|            protein tyrosine phosphatase receptor-type C (PTPRC) gene, coding
CC   GPRFLN|            for the CD45 molecule, for the development of multiple sclerosis
CC   GPRFLN|            (MS) in Italy.
CC   GPRFLN|REFERENCE   6  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Yamada,T., Zhu,D., Saxon,A. and Zhang,K.
CC   GPRFLN|  TITLE     CD45 controls interleukin-4-mediated IgE class switch recombination
CC   GPRFLN|            in human B cells through its function as a Janus kinase phosphatase
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (32), 28830-28835 (2002)
CC   GPRFLN|  MEDLINE   22151051
CC   GPRFLN|  REMARK    GeneRIF: CD45 controls interleukin-4-mediated IgE class switch
CC   GPRFLN|            recombination in human B cells
CC   GPRFLN|REFERENCE   7  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Yu,C., Yu,H.S., Sun,K.H., Hsieh,S.C. and Tsai,C.Y.
CC   GPRFLN|  TITLE     Anti-CD45 isoform antibodies enhance phagocytosis and gene
CC   GPRFLN|            expression of IL-8 and TNF-alpha in human neutrophils by
CC   GPRFLN|            differential suppression on protein tyrosine phosphorylation and
CC   GPRFLN|            p56lck tyrosine kinase
CC   GPRFLN|  JOURNAL   Clin. Exp. Immunol. 129 (1), 78-85 (2002)
CC   GPRFLN|  MEDLINE   22095000
CC   GPRFLN|  REMARK    GeneRIF: Biological functions of membrane expressed CD45 isoforms
CC   GPRFLN|            on PMNs were studied. Cross-linking of CD45 isoforms by specific
CC   GPRFLN|            MAbs stimulated different PMN activities by differential
CC   GPRFLN|            suppression on protein tyrosine phosphorylation and p56lck.
CC   GPRFLN|REFERENCE   8  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Jacobsen,M., Hoffmann,S., Cepok,S., Stei,S., Ziegler,A., Sommer,N.
CC   GPRFLN|            and Hemmer,B.
CC   GPRFLN|  TITLE     A novel mutation in PTPRC interferes with splicing and alters the
CC   GPRFLN|            structure of the human CD45 molecule
CC   GPRFLN|  JOURNAL   Immunogenetics 54 (3), 158-163 (2002)
CC   GPRFLN|  MEDLINE   22067726
CC   GPRFLN|  REMARK    GeneRIF: a mutation in PTPRC interferes with splicing and alters
CC   GPRFLN|            the structure of the CD45 molecule
CC   GPRFLN|REFERENCE   9  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Tchilian,E.Z. and Beverley,P.C.
CC   GPRFLN|  TITLE     CD45 in memory and disease
CC   GPRFLN|  JOURNAL   Arch. Immunol. Ther. Exp. (Warsz.) 50 (2), 85-93 (2002)
CC   GPRFLN|  MEDLINE   22017393
CC   GPRFLN|  REMARK    GeneRIF: Role of high and low molecular weight isoforms of CD45 in
CC   GPRFLN|            the function of na##ve and memory T lymphocytes. Review.
CC   GPRFLN|REFERENCE   10 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Fajka-Boja,R., Szemes,M., Ion,G., Legradi,A., Caron,M. and
CC   GPRFLN|            Monostori,E.
CC   GPRFLN|  TITLE     Receptor tyrosine phosphatase, CD45 binds galectin-1 but does not
CC   GPRFLN|            mediate its apoptotic signal in T cell lines
CC   GPRFLN|  JOURNAL   Immunol. Lett. 82 (1-2), 149-154 (2002)
CC   GPRFLN|  MEDLINE   22003829
CC   GPRFLN|  REMARK    GeneRIF: Receptor tyrosine phosphatase, CD45 binds galectin-1 but
CC   GPRFLN|            does not mediate its apoptotic signal in Jurkat cells
CC   GPRFLN|REFERENCE   11 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Fukuhara,K., Okumura,M., Shiono,H., Inoue,M., Kadota,Y., Miyoshi,S.
CC   GPRFLN|            and Matsuda,H.
CC   GPRFLN|  TITLE     A study on CD45 isoform expression during T-cell development and
CC   GPRFLN|            selection events in the human thymus
CC   GPRFLN|  JOURNAL   Hum. Immunol. 63 (5), 394-404 (2002)
CC   GPRFLN|  MEDLINE   21972715
CC   GPRFLN|  REMARK    GeneRIF: analysis of CD45 isoform expression during T-cell
CC   GPRFLN|            development and selection in the human thymus
CC   GPRFLN|REFERENCE   12 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Wu,L., Fu,J. and Shen,S.H.
CC   GPRFLN|  TITLE     SKAP55 coupled with CD45 positively regulates T-cell
CC   GPRFLN|            receptor-mediated gene transcription
CC   GPRFLN|  JOURNAL   Mol. Cell. Biol. 22 (8), 2673-2686 (2002)
CC   GPRFLN|  MEDLINE   21907230
CC   GPRFLN|  REMARK    GeneRIF: SKAP55 coupled with CD45 positively regulates T-cell
CC   GPRFLN|            receptor-mediated gene transcription.
CC   GPRFLN|REFERENCE   13 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Ishikawa,H., Tsuyama,N., Abroun,S., Liu,S., Li,F.J., Taniguchi,O.
CC   GPRFLN|            and Kawano,M.M.
CC   GPRFLN|  TITLE     Requirements of src family kinase activity associated with CD45 for
CC   GPRFLN|            myeloma cell proliferation by interleukin-6
CC   GPRFLN|  JOURNAL   Blood 99 (6), 2172-2178 (2002)
CC   GPRFLN|  MEDLINE   21866149
CC   GPRFLN|  REMARK    GeneRIF: Requirements of src family kinase activity associated with
CC   GPRFLN|            CD45 for myeloma cell proliferation by interleukin-6
CC   GPRFLN|REFERENCE   14 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Tchilian,E.Z., Dawes,R., Ramaley,P.A., Whitworth,J.A.,
CC   GPRFLN|            Yuldasheva,N., Wells,R.S., Watera,C., French,N., Gilks,C.F.,
CC   GPRFLN|            Kunachiwa,W., Ruzibakiev,R., Leetrakool,N., Carrington,C.V.,
CC   GPRFLN|            Ramdath,D.D., Gotch,F., Stephens,H.A., Hill,A.V. and Beverley,P.C.
CC   GPRFLN|  TITLE     A CD45 polymorphism associated with abnormal splicing is absent in
CC   GPRFLN|            African populations
CC   GPRFLN|  JOURNAL   Immunogenetics 53 (10-11), 980-983 (2002)
CC   GPRFLN|  MEDLINE   21850514
CC   GPRFLN|  REMARK    GeneRIF: we examined the frequency of the C77G allele in African
CC   GPRFLN|            and Asian populations from countries with high or low prevalence of
CC   GPRFLN|            HIV infection; Here we report that the variant CD45 C77G allele is
CC   GPRFLN|            absent in African populations
CC   GPRFLN|REFERENCE   15 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Wood,J.P., Bieda,K., Segni,M., Herwig,J., Krause,M., Usadel,K.H.
CC   GPRFLN|            and Badenhoop,K.
CC   GPRFLN|  TITLE     CD45 exon 4 point mutation does not confer susceptibility to type 1
CC   GPRFLN|            diabetes mellitus or Graves' disease
CC   GPRFLN|  JOURNAL   Eur. J. Immunogenet. 29 (1), 73-74 (2002)
CC   GPRFLN|  MEDLINE   21830605
CC   GPRFLN|  REMARK    GeneRIF: CD45 variant (C77G, exon 4) does not confer susceptibility
CC   GPRFLN|            to either IDDM or Graves' disease
CC   GPRFLN|REFERENCE   16 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Moro,H., Iwai,K., Mori,N., Watanabe,M., Fukushi,M., Oie,M.,
CC   GPRFLN|            Arai,M., Tanaka,Y., Miyawaki,T., Gejyo,F., Arakawa,M. and Fujii,M.
CC   GPRFLN|  TITLE     Interleukin-2-dependent but not independent T-cell lines infected
CC   GPRFLN|            with human T-cell leukemia virus type 1 selectively express CD45RO,
CC   GPRFLN|            a marker for persistent infection in vivo
CC   GPRFLN|  JOURNAL   Virus Genes 23 (3), 263-271 (2001)
CC   GPRFLN|  MEDLINE   21636965
CC   GPRFLN|  REMARK    GeneRIF: role of CD45RO in the persistent HTLV-1 infection in vivo
CC   GPRFLN|REFERENCE   17 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Irie-Sasaki,J., Sasaki,T., Matsumoto,W., Opavsky,A., Cheng,M.,
CC   GPRFLN|            Welstead,G., Griffiths,E., Krawczyk,C., Richardson,C.D., Aitken,K.,
CC   GPRFLN|            Iscove,N., Koretzky,G., Johnson,P., Liu,P., Rothstein,D.M. and
CC   GPRFLN|            Penninger,J.M.
CC   GPRFLN|  TITLE     CD45 is a JAK phosphatase and negatively regulates cytokine
CC   GPRFLN|            receptor signalling
CC   GPRFLN|  JOURNAL   Nature 409 (6818), 349-354 (2001)
CC   GPRFLN|  MEDLINE   21069057
CC   GPRFLN|REFERENCE   18 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Goff,L.K., van Soest,S., Timon,M., Tchilian,E. and Beverley,P.C.
CC   GPRFLN|  TITLE     Protein tyrosine phosphatase receptor type C polypeptide (PTPRC) on
CC   GPRFLN|            human chromosome band 1q31-->q32 localizes with marker D1S413(1) on
CC   GPRFLN|            a 610-kb yeast artificial chromosome
CC   GPRFLN|  JOURNAL   Cytogenet. Cell Genet. 87 (3-4), 223-224 (1999)
CC   GPRFLN|  MEDLINE   20169194
CC   GPRFLN|REFERENCE   19 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Petricoin,E.F. III, Ito,S., Williams,B.L., Audet,S., Stancato,L.F.,
CC   GPRFLN|            Gamero,A., Clouse,K., Grimley,P., Weiss,A., Beeler,J.,
CC   GPRFLN|            Finbloom,D.S., Shores,E.W., Abraham,R. and Larner,A.C.
CC   GPRFLN|  TITLE     Antiproliferative action of interferon-alpha requires components of
CC   GPRFLN|            T-cell-receptor signalling
CC   GPRFLN|  JOURNAL   Nature 390 (6660), 629-632 (1997)
CC   GPRFLN|  MEDLINE   98065953
CC   GPRFLN|REFERENCE   20 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Kaplan,R., Morse,B., Huebner,K., Croce,C., Howk,R., Ravera,M.,
CC   GPRFLN|            Ricca,G., Jaye,M. and Schlessinger,J.
CC   GPRFLN|  TITLE     Cloning of three human tyrosine phosphatases reveals a multigene
CC   GPRFLN|            family of receptor-linked protein-tyrosine-phosphatases expressed
CC   GPRFLN|            in brain
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (18), 7000-7004 (1990)
CC   GPRFLN|  MEDLINE   90384936
CC   GPRFLN|REFERENCE   21 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Schraven,B., Samstag,Y., Altevogt,P. and Meuer,S.C.
CC   GPRFLN|  TITLE     Association of CD2 and CD45 on human T lymphocytes
CC   GPRFLN|  JOURNAL   Nature 345 (6270), 71-74 (1990)
CC   GPRFLN|  MEDLINE   90231464
CC   GPRFLN|REFERENCE   22 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Pingel,J.T. and Thomas,M.L.
CC   GPRFLN|  TITLE     Evidence that the leukocyte-common antigen is required for
CC   GPRFLN|            antigen-induced T lymphocyte proliferation
CC   GPRFLN|  JOURNAL   Cell 58 (6), 1055-1065 (1989)
CC   GPRFLN|  MEDLINE   89376557
CC   GPRFLN|REFERENCE   23 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Charbonneau,H., Tonks,N.K., Walsh,K.A. and Fischer,E.H.
CC   GPRFLN|  TITLE     The leukocyte common antigen (CD45): a putative receptor-linked
CC   GPRFLN|            protein tyrosine phosphatase
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 85 (19), 7182-7186 (1988)
CC   GPRFLN|  MEDLINE   89017162
CC   GPRFLN|REFERENCE   24 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Streuli,M., Hall,L.R., Saga,Y., Schlossman,S.F. and Saito,H.
CC   GPRFLN|  TITLE     Differential usage of three exons generates at least five different
CC   GPRFLN|            mRNAs encoding human leukocyte common antigens
CC   GPRFLN|  JOURNAL   J. Exp. Med. 166 (5), 1548-1566 (1987)
CC   GPRFLN|  MEDLINE   88061067
CC   GPRFLN|REFERENCE   25 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Ralph,S.J., Thomas,M.L., Morton,C.C. and Trowbridge,I.S.
CC   GPRFLN|  TITLE     Structural variants of human T200 glycoprotein (leukocyte-common
CC   GPRFLN|            antigen)
CC   GPRFLN|  JOURNAL   EMBO J. 6 (5), 1251-1257 (1987)
CC   GPRFLN|  MEDLINE   87275816
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    308       VNTIFKEY:269
FT   PROTEIN       1    308       protein tyrosine phosphatase, receptor type, c polypeptide; leukocyte-common antigen; T200 glycoprotein; human homolog of severe combined immunodeficiency due to PTPRC deficiency; SCID due to PTPRC deficiency; CD45 antigen
FT                                VNTIFKEY:270
FT   CHAIN         1    308       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       22    307       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_3
SQ   SEQUENCE   308 AA;
     SELHPYLHNM KKRDPPSEPS PLEAEFQRLP SYRSWRTQHI GNQEENKSKN RNSNVIPYDY        60
     NRVPLKHELE MSKESEHDSD ESSDDDSDSE EPSKYINASF IMSYWKPEVM IAAQGPLKET       120
     IGDFWQMIFQ RKVKVIVMLT ELKHGDQEIC AQYWGEGKQT YGDIEVDLKD TDKSSTYTLR       180
     VFELRHSKRK DSRTVYQYQY TNWSVEQLPA EPKELISMIQ VVKQKLPQKN SSEGNKHHKS       240
     TPLLIHCRDG SQQTGIFCAL LNLLESAETE EVVDIFQVVK ALRKARPGMV STFEQYQFLY       300
     DVIASTYP                                                                308
//
ID   hLAR_D2\(NP_002831)\PTPRF STANDARD;PRT;   283 AA.
AC   NP_002831;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, F isoform 1 precursor; protein tyrosine phosphatase, receptor type, F polypeptide; receptor-linked protein-tyrosine phosphatase LAR; leukocyte antigen-related tyrosine phosphatase; LCA-homolog [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from Y00815.1 and BI711143.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP possesses an extracellular
CC   region, a single transmembrane region, and two tandem
CC   intracytoplasmic catalytic domains, and thus represents a
CC   receptor-type PTP. The extracellular region contains three Ig-like
CC   domains, and nine non-Ig like domains similar to that of
CC   neural-cell adhesion molecule. This PTP was shown to function in
CC   the regulation of epithelial cell-cell contacts at adherents
CC   junctions, as well as in the control of beta-catenin signaling. An
CC   increased expression level of this protein was found in the
CC   insulin-responsive tissue of obese, insulin-resistant individuals,
CC   and may contribute to the pathogenesis of insulin resistance. Two
CC   alternatively spliced transcript variants of this gene, which
CC   encode distinct proteins, have been reported.
CC   
CC   Transcript Variant: This variant (1) contains an extra internal
CC   fragment within the coding region when compared to variant 2. It
CC   thus encodes a protein that has a 9 aa internal fragment absent in
CC   isoform 2.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1897)
CC   GPRFLN|  AUTHORS   Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J.
CC   GPRFLN|  TITLE     Intra- and intermolecular interactions between intracellular
CC   GPRFLN|            domains of receptor protein-tyrosine phosphatases
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (49), 47263-47269 (2002)
CC   GPRFLN|  MEDLINE   22344739
CC   GPRFLN|  REMARK    GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are
CC   GPRFLN|            a common but specific mechanism that is likely to be regulated-
CC   GPRFLN|            domain2s and the wedge structures are crucial determinants of
CC   GPRFLN|            binding specificity, thus regulating cross-talk between RPTPs
CC   GPRFLN|REFERENCE   2  (residues 1 to 1897)
CC   GPRFLN|  AUTHORS   Symons,J.R., LeVea,C.M. and Mooney,R.A.
CC   GPRFLN|  TITLE     Expression of the leucocyte common antigen-related (LAR) tyrosine
CC   GPRFLN|            phosphatase is regulated by cell density through functional
CC   GPRFLN|            E-cadherin complexes
CC   GPRFLN|  JOURNAL   Biochem. J. 365 (Pt 2), 513-519 (2002)
CC   GPRFLN|  MEDLINE   22090243
CC   GPRFLN|  REMARK    GeneRIF: regulation of expression by cell density through
CC   GPRFLN|            functional E-cadherin complexes
CC   GPRFLN|REFERENCE   3  (residues 1 to 1897)
CC   GPRFLN|  AUTHORS   Zabolotny,J.M., Kim,Y.B., Peroni,O.D., Kim,J.K., Pani,M.A.,
CC   GPRFLN|            Boss,O., Klaman,L.D., Kamatkar,S., Shulman,G.I., Kahn,B.B. and
CC   GPRFLN|            Neel,B.G.
CC   GPRFLN|  TITLE     Overexpression of the LAR (leukocyte antigen-related)
CC   GPRFLN|            protein-tyrosine phosphatase in muscle causes insulin resistance
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 98 (9), 5187-5192 (2001)
CC   GPRFLN|  MEDLINE   21221100
CC   GPRFLN|REFERENCE   4  (residues 1 to 1897)
CC   GPRFLN|  AUTHORS   Muller,T., Choidas,A., Reichmann,E. and Ullrich,A.
CC   GPRFLN|  TITLE     Phosphorylation and free pool of beta-catenin are regulated by
CC   GPRFLN|            tyrosine kinases and tyrosine phosphatases during epithelial cell
CC   GPRFLN|            migration
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 274 (15), 10173-10183 (1999)
CC   GPRFLN|  MEDLINE   99214576
CC   GPRFLN|REFERENCE   5  (residues 1 to 1897)
CC   GPRFLN|  AUTHORS   Ahmad,F. and Goldstein,B.J.
CC   GPRFLN|  TITLE     Functional association between the insulin receptor and the
CC   GPRFLN|            transmembrane protein-tyrosine phosphatase LAR in intact cells
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 272 (1), 448-457 (1997)
CC   GPRFLN|  MEDLINE   97150746
CC   GPRFLN|REFERENCE   6  (residues 1 to 1897)
CC   GPRFLN|  AUTHORS   Harder,K.W., Saw,J., Miki,N. and Jirik,F.
CC   GPRFLN|  TITLE     Coexisting amplifications of the chromosome 1p32 genes (PTPRF and
CC   GPRFLN|            MYCL1) encoding protein tyrosine phosphatase LAR and L-myc in a
CC   GPRFLN|            small cell lung cancer line
CC   GPRFLN|  JOURNAL   Genomics 27 (3), 552-553 (1995)
CC   GPRFLN|  MEDLINE   96047346
CC   GPRFLN|REFERENCE   7  (residues 1 to 1897)
CC   GPRFLN|  AUTHORS   Schaapveld,R.Q., van den Maagdenberg,A.M., Schepens,J.T.,
CC   GPRFLN|            Weghuis,D.O., Geurts van Kessel,A., Wieringa,B. and Hendriks,W.J.
CC   GPRFLN|  TITLE     The mouse gene Ptprf encoding the leukocyte common antigen-related
CC   GPRFLN|            molecule LAR: cloning, characterization, and chromosomal
CC   GPRFLN|            localization
CC   GPRFLN|  JOURNAL   Genomics 27 (1), 124-130 (1995)
CC   GPRFLN|  MEDLINE   95394448
CC   GPRFLN|REFERENCE   8  (residues 1 to 1897)
CC   GPRFLN|  AUTHORS   O'Grady,P., Krueger,N.X., Streuli,M. and Saito,H.
CC   GPRFLN|  TITLE     Genomic organization of the human LAR protein tyrosine phosphatase
CC   GPRFLN|            gene and alternative splicing in the extracellular fibronectin
CC   GPRFLN|            type-III domains
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 269 (40), 25193-25199 (1994)
CC   GPRFLN|  MEDLINE   95014301
CC   GPRFLN|REFERENCE   9  (residues 1 to 1897)
CC   GPRFLN|  AUTHORS   Streuli,M., Krueger,N.X., Hall,L.R., Schlossman,S.F. and Saito,H.
CC   GPRFLN|  TITLE     A new member of the immunoglobulin superfamily that has a
CC   GPRFLN|            cytoplasmic region homologous to the leukocyte common antigen
CC   GPRFLN|  JOURNAL   J. Exp. Med. 168 (5), 1523-1530 (1988)
CC   GPRFLN|  MEDLINE   89035978
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    283       VNTIFKEY:269
FT   PROTEIN       1    283       protein tyrosine phosphatase, receptor type, F polypeptide; receptor-linked protein-tyrosine phosphatase LAR; leukocyte antigen-related tyrosine phosphatase; LCA-homolog
FT                                VNTIFKEY:270
FT   CHAIN         1    283       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       25    282       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_5
SQ   SEQUENCE   283 AA;
     RNLYAHIQKL GQVPPGESVT AMELEFKLLA SSKAHTSRFI SANLPCNKFK NRLVNIMPYE        60
     LTRVCLQPIR GVEGSDYINA SFLDGYRQQK AYIATQGPLA ESTEDFWRML WEHNSTIIVM       120
     LTKLREMGRE KCHQYWPAER SARYQYFVVD PMAEYNMPQY ILREFKVTDA RDGQSRTIRQ       180
     FQFTDWPEQG VPKTGEGFID FIGQVHKTKE QFGQDGPITV HCSAGVGRTG VFITLSIVLE       240
     RMRYEGVVDM FQTVKTLRTQ RPAMVQTEDQ YQLCYRAALE YLG                         283
//
ID   hPTPalpha_D2\(NP_002827)\PTPRA STANDARD;PRT;   282 AA.
AC   NP_002827;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, A isoform 1 precursor; protein tyrosine phosphatase, receptor type, alpha polypeptide; PTPase-alpha; Leukocyte common antigen-related peptide (protein tyrosine phosphate); tyrosine phosphatase alpha; PTPLCA-related phosphatase [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from M34668.1 and AI284972.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP contains an extracellular
CC   domain, a single transmembrane segment and two tandem
CC   intracytoplasmic catalytic domains, and thus represents a
CC   receptor-type PTP. This PTP has been shown to dephosphorylate and
CC   activate Src family tyrosine kinases, and is implicated in the
CC   regulation of integrin signaling, cell adhesion and proliferation.
CC   Three alternatively spliced variants of this gene, which encode two
CC   distinct isoforms, have been reported.
CC   
CC   Transcript Variant: This variant (1) contains a unique 5' UTR
CC   region when compared to other variants. The genomic exons forming
CC   the 5' end region of this transcript are also used to form an
CC   internal coding region in the transcripts of VPS16, a distinct gene
CC   located at the locus immediately upstream of this gene on
CC   chromosome 20. This variant encodes the longest isoform (1).
CC   GPRFLN|REFERENCE   1  (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J.
CC   GPRFLN|  TITLE     Intra- and intermolecular interactions between intracellular
CC   GPRFLN|            domains of receptor protein-tyrosine phosphatases
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (49), 47263-47269 (2002)
CC   GPRFLN|  MEDLINE   22344739
CC   GPRFLN|  REMARK    GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are
CC   GPRFLN|            a common but specific mechanism that is likely to be regulated-
CC   GPRFLN|            domain2s and the wedge structures are crucial determinants of
CC   GPRFLN|            binding specificity, thus regulating cross-talk between RPTPs
CC   GPRFLN|REFERENCE   2  (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Mustelin,T. and Hunter,T.
CC   GPRFLN|  TITLE     Meeting at mitosis: cell cycle-specific regulation of c-Src by
CC   GPRFLN|            RPTPalpha
CC   GPRFLN|  JOURNAL   Sci STKE 2002 (115), PE3 (2002)
CC   GPRFLN|  MEDLINE   21655780
CC   GPRFLN|  REMARK    GeneRIF: In entering mitosis the cell cycle-specific regulation of
CC   GPRFLN|            c-Src by RPTPalpha can occur by dephosphorylation of phospho-Tyr527
CC   GPRFLN|            that activates c-Src in a reaction catalyzed by the transmembrane
CC   GPRFLN|            receptor-like protein tyrosine phosphatase RPTPalpha.
CC   GPRFLN|REFERENCE   3  (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Ardini,E., Agresti,R., Tagliabue,E., Greco,M., Aiello,P.,
CC   GPRFLN|            Yang,L.T., Menard,S. and Sap,J.
CC   GPRFLN|  TITLE     Expression of protein tyrosine phosphatase alpha (RPTPalpha) in
CC   GPRFLN|            human breast cancer correlates with low tumor grade, and inhibits
CC   GPRFLN|            tumor cell growth in vitro and in vivo
CC   GPRFLN|  JOURNAL   Oncogene 19 (43), 4979-4987 (2000)
CC   GPRFLN|  MEDLINE   20499263
CC   GPRFLN|REFERENCE   4  (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Peters,G.H., Iversen,L.F., Branner,S., Andersen,H.S.,
CC   GPRFLN|            Mortensen,S.B., Olsen,O.H., Moller,K.B. and Moller,N.P.
CC   GPRFLN|  TITLE     Residue 259 is a key determinant of substrate specificity of
CC   GPRFLN|            protein-tyrosine phosphatases 1B and alpha
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 275 (24), 18201-18209 (2000)
CC   GPRFLN|  MEDLINE   20309769
CC   GPRFLN|REFERENCE   5  (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Harder,K.W., Moller,N.P., Peacock,J.W. and Jirik,F.R.
CC   GPRFLN|  TITLE     Protein-tyrosine phosphatase alpha regulates Src family kinases and
CC   GPRFLN|            alters cell-substratum adhesion
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 273 (48), 31890-31900 (1998)
CC   GPRFLN|  MEDLINE   99041953
CC   GPRFLN|REFERENCE   6  (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Zheng,X.M., Wang,Y. and Pallen,C.J.
CC   GPRFLN|  TITLE     Cell transformation and activation of pp60c-src by overexpression
CC   GPRFLN|            of a protein tyrosine phosphatase
CC   GPRFLN|  JOURNAL   Nature 359 (6393), 336-339 (1992)
CC   GPRFLN|  MEDLINE   93024881
CC   GPRFLN|REFERENCE   7  (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Rao,V.V., Loffler,C., Sap,J., Schlessinger,J. and Hansmann,I.
CC   GPRFLN|  TITLE     The gene for receptor-linked protein-tyrosine-phosphatase (PTPA) is
CC   GPRFLN|            assigned to human chromosome 20p12-pter by in situ hybridization
CC   GPRFLN|            (ISH and FISH)
CC   GPRFLN|  JOURNAL   Genomics 13 (3), 906-907 (1992)
CC   GPRFLN|  MEDLINE   92347910
CC   GPRFLN|REFERENCE   8  (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Ohagi,S., Nishi,M. and Steiner,D.F.
CC   GPRFLN|  TITLE     Sequence of a cDNA encoding human LRP (leukocyte common
CC   GPRFLN|            antigen-related peptide)
CC   GPRFLN|  JOURNAL   Nucleic Acids Res. 18 (23), 7159 (1990)
CC   GPRFLN|  MEDLINE   91088320
CC   GPRFLN|REFERENCE   9  (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Jirik,F.R., Janzen,N.M., Melhado,I.G. and Harder,K.W.
CC   GPRFLN|  TITLE     Cloning and chromosomal assignment of a widely expressed human
CC   GPRFLN|            receptor-like protein-tyrosine phosphatase
CC   GPRFLN|  JOURNAL   FEBS Lett. 273 (1-2), 239-242 (1990)
CC   GPRFLN|  MEDLINE   91032191
CC   GPRFLN|REFERENCE   10 (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Krueger,N.X., Streuli,M. and Saito,H.
CC   GPRFLN|  TITLE     Structural diversity and evolution of human receptor-like protein
CC   GPRFLN|            tyrosine phosphatases
CC   GPRFLN|  JOURNAL   EMBO J. 9 (10), 3241-3252 (1990)
CC   GPRFLN|  MEDLINE   91006018
CC   GPRFLN|REFERENCE   11 (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Kaplan,R., Morse,B., Huebner,K., Croce,C., Howk,R., Ravera,M.,
CC   GPRFLN|            Ricca,G., Jaye,M. and Schlessinger,J.
CC   GPRFLN|  TITLE     Cloning of three human tyrosine phosphatases reveals a multigene
CC   GPRFLN|            family of receptor-linked protein-tyrosine-phosphatases expressed
CC   GPRFLN|            in brain
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (18), 7000-7004 (1990)
CC   GPRFLN|  MEDLINE   90384936
CC   GPRFLN|REFERENCE   12 (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Sap,J., D'Eustachio,P., Givol,D. and Schlessinger,J.
CC   GPRFLN|  TITLE     Cloning and expression of a widely expressed receptor tyrosine
CC   GPRFLN|            phosphatase
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (16), 6112-6116 (1990)
CC   GPRFLN|  MEDLINE   90349565
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    282       VNTIFKEY:269
FT   PROTEIN       1    282       protein tyrosine phosphatase, receptor type, alpha polypeptide; PTPase-alpha; Leukocyte common antigen-related peptide (protein tyrosine phosphate); tyrosine phosphatase alpha; PTPLCA-related phosphatase
FT                                VNTIFKEY:270
FT   CHAIN         1    282       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       21    281       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_2
SQ   SEQUENCE   282 AA;
     TSLETHLQKI YNKIPGTSNN GLEEEFKKLT SIKIQNDKMR TGNLPANMKK NRVLQIIPYE        60
     FNRVIIPVKR GEENTDYVNA SFIDGYRQKD SYIASQGPLL HTIEDFWRMI WEWKSCSIVM       120
     LTELEERGQE KCAQYWPSDG LVSYGDITVE LKKEEECESY TVRDLLVTNT RENKSRQIRQ       180
     FHFHGWPEVG IPSDGKGMIS IIAAVQKQQQ QSGNHPITVH CSAGAGRTGT FCALSTVLER       240
     VKAEGILDVF QTVKSLRLQR PHMVQTLEQY EFCYKVVQEY ID                          282
//
ID   hPTPdelta_D2\(NP_002830)\PTPRD STANDARD;PRT;   283 AA.
AC   NP_002830;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, D isoform 1 precursor; protein tyrosine phosphatase, receptor type, delta polypeptide; protein tyrosine phosphatase delta [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from L38929.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP contains an extracellular
CC   region, a single transmembrane segment and two tandem
CC   intracytoplasmic catalytic domains, thus represents a receptor-type
CC   PTP. The extracellular region of this protein is composed of three
CC   Ig-like and eight fibronectin type III-like domains. Studies of the
CC   similar genes in chick and fly suggest the role of this PTP is in
CC   promoting neurite growth, and regulating neurons axon guidance.
CC   Multiple tissue specific alternatively spliced transcript variants
CC   of this gene have been reported.
CC   
CC   Transcript Variant: This variant (1) encodes the longest isoform
CC   (1).
CC   GPRFLN|REFERENCE   1  (residues 1 to 1912)
CC   GPRFLN|  AUTHORS   Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J.
CC   GPRFLN|  TITLE     Intra- and intermolecular interactions between intracellular
CC   GPRFLN|            domains of receptor protein-tyrosine phosphatases
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (49), 47263-47269 (2002)
CC   GPRFLN|  MEDLINE   22344739
CC   GPRFLN|  REMARK    GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are
CC   GPRFLN|            a common but specific mechanism that is likely to be regulated-
CC   GPRFLN|            domain2s and the wedge structures are crucial determinants of
CC   GPRFLN|            binding specificity, thus regulating cross-talk between RPTPs
CC   GPRFLN|REFERENCE   2  (residues 1 to 1912)
CC   GPRFLN|  AUTHORS   Pulido,R., Serra-Pages,C., Tang,M. and Streuli,M.
CC   GPRFLN|  TITLE     The LAR/PTP delta/PTP sigma subfamily of transmembrane
CC   GPRFLN|            protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and
CC   GPRFLN|            PTP sigma isoforms are expressed in a tissue-specific manner and
CC   GPRFLN|            associate with the LAR-interacting protein LIP.1
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (25), 11686-11690 (1995)
CC   GPRFLN|  MEDLINE   96102179
CC   GPRFLN|REFERENCE   3  (residues 1 to 1912)
CC   GPRFLN|  AUTHORS   Pulido,R., Krueger,N.X., Serra-Pages,C., Saito,H. and Streuli,M.
CC   GPRFLN|  TITLE     Molecular characterization of the human transmembrane
CC   GPRFLN|            protein-tyrosine phosphatase delta. Evidence for tissue-specific
CC   GPRFLN|            expression of alternative human transmembrane protein-tyrosine
CC   GPRFLN|            phosphatase delta isoforms
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 270 (12), 6722-6728 (1995)
CC   GPRFLN|  MEDLINE   95204468
CC   GPRFLN|REFERENCE   4  (residues 1 to 1912)
CC   GPRFLN|  AUTHORS   Krueger,N.X., Streuli,M. and Saito,H.
CC   GPRFLN|  TITLE     Structural diversity and evolution of human receptor-like protein
CC   GPRFLN|            tyrosine phosphatases
CC   GPRFLN|  JOURNAL   EMBO J. 9 (10), 3241-3252 (1990)
CC   GPRFLN|  MEDLINE   91006018
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    283       VNTIFKEY:269
FT   PROTEIN       1    283       protein tyrosine phosphatase, receptor type, delta polypeptide; protein tyrosine phosphatase delta
FT                                VNTIFKEY:270
FT   CHAIN         1    283       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       21    282       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_5
SQ   SEQUENCE   283 AA;
     RNLYAYIQKL TQIETGENVT GMELEFKRLA SSKAHTSRFI SANLPCNKFK NRLVNIMPYE        60
     STRVCLQPIR GVEGSDYINA SFIDGYRQQK AYIATQGPLA ETTEDFWRML WEHNSTIVVM       120
     LTKLREMGRE KCHQYWPAER SARYQYFVVD PMAEYNMPQY ILREFKVTDA RDGQSRTVRQ       180
     FQFTDWPEQG VPKSGEGFID FIGQVHKTKE QFGQDGPISV HCSAGVGRTG VFITLSIVLE       240
     RMRYEGVVDI FQTVKMLRTQ RPAMVQTEDQ YQFSYRAALE YLG                         283
//
ID   hPTPepsilon_D2\(NP_006495)\PTPRE STANDARD;PRT;   287 AA.
AC   NP_006495;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, E isoform 1 precursor; protein tyrosine phosphatase, receptor type, epsilon; protein tyrosine phosphatase, receptor type, epsilon polypeptide; protein tyrosine phosphatase epsilon [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from X54134.1, AJ315969.1 and
CC   BI559814.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. Two alternatively spliced transcript
CC   variants of this gene have been reported, one of which encodes a
CC   receptor-type PTP that possesses a short extracellular domain, a
CC   single transmembrane region, and two tandem intracytoplasmic
CC   catalytic domains; Another one encodes a PTP that contains a
CC   distinct hydrophilic N-terminus, and thus represents a
CC   nonreceptor-type isoform of this PTP. Studies of the similar gene
CC   in mice suggested the regulatory roles of this PTP in RAS related
CC   signal transduction pathways, cytokines induced SATA signaling, as
CC   well as the activation of voltage-gated K+ channels.
CC   
CC   Transcript Variant: This variant (1) contains a different 5' end
CC   region that includes a part of the coding region, when compared to
CC   variant 2. It thus encodes a protein that has a distinct
CC   N-terminus, as compared to isoform 2. The encoded protein is a
CC   receptor type isoform of this PTP.
CC   GPRFLN|REFERENCE   1  (residues 1 to 700)
CC   GPRFLN|  AUTHORS   Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J.
CC   GPRFLN|  TITLE     Intra- and intermolecular interactions between intracellular
CC   GPRFLN|            domains of receptor protein-tyrosine phosphatases
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (49), 47263-47269 (2002)
CC   GPRFLN|  MEDLINE   22344739
CC   GPRFLN|  REMARK    GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are
CC   GPRFLN|            a common but specific mechanism that is likely to be regulated-
CC   GPRFLN|            domain2s and the wedge structures are crucial determinants of
CC   GPRFLN|            binding specificity, thus regulating cross-talk between RPTPs
CC   GPRFLN|REFERENCE   2  (residues 1 to 700)
CC   GPRFLN|  AUTHORS   Wabakken,T., Hauge,H., Funderud,S. and Aasheim,H.C.
CC   GPRFLN|  TITLE     Characterization, expression and functional aspects of a novel
CC   GPRFLN|            protein tyrosine phosphatase epsilon isoform
CC   GPRFLN|  JOURNAL   Scand. J. Immunol. 56 (3), 276-285 (2002)
CC   GPRFLN|  MEDLINE   22181756
CC   GPRFLN|  REMARK    GeneRIF: Characterization, expression and functional aspects of an
CC   GPRFLN|            alternative spliced isoform of protein tyrosine phosphatase epsilon
CC   GPRFLN|REFERENCE   3  (residues 1 to 700)
CC   GPRFLN|  AUTHORS   Wabakken,T., Hauge,H., Finne,E.F., Wiedlocha,A. and Aasheim,H.
CC   GPRFLN|  TITLE     Expression of human protein tyrosine phosphatase epsilon in
CC   GPRFLN|            leucocytes: a potential ERK pathway-regulating phosphatase
CC   GPRFLN|  JOURNAL   Scand. J. Immunol. 56 (2), 195-203 (2002)
CC   GPRFLN|  MEDLINE   22118122
CC   GPRFLN|  REMARK    GeneRIF: Transfection of cells with different PTPepsilon constructs
CC   GPRFLN|            and activator protein-1 reporter gene indicates that the catalytic
CC   GPRFLN|            activity of PTPepsilon is involved in the regulation of the
CC   GPRFLN|            mitogen-activated protein kinase cascade.
CC   GPRFLN|REFERENCE   4  (residues 1 to 700)
CC   GPRFLN|  AUTHORS   Tanuma,N., Nakamura,K., Shima,H. and Kikuchi,K.
CC   GPRFLN|  TITLE     Protein-tyrosine phosphatase PTPepsilon C inhibits Jak-STAT
CC   GPRFLN|            signaling and differentiation induced by interleukin-6 and leukemia
CC   GPRFLN|            inhibitory factor in M1 leukemia cells
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 275 (36), 28216-28221 (2000)
CC   GPRFLN|  MEDLINE   20428741
CC   GPRFLN|  REMARK    functional study of the mouse homolog
CC   GPRFLN|REFERENCE   5  (residues 1 to 700)
CC   GPRFLN|  AUTHORS   Peretz,A., Gil-Henn,H., Sobko,A., Shinder,V., Attali,B. and
CC   GPRFLN|            Elson,A.
CC   GPRFLN|  TITLE     Hypomyelination and increased activity of voltage-gated K(+)
CC   GPRFLN|            channels in mice lacking protein tyrosine phosphatase epsilon
CC   GPRFLN|  JOURNAL   EMBO J. 19 (15), 4036-4045 (2000)
CC   GPRFLN|  MEDLINE   20380937
CC   GPRFLN|  REMARK    functional study of the mouse homolog
CC   GPRFLN|REFERENCE   6  (residues 1 to 700)
CC   GPRFLN|  AUTHORS   Toledano-Katchalski,H. and Elson,A.
CC   GPRFLN|  TITLE     The transmembranal and cytoplasmic forms of protein tyrosine
CC   GPRFLN|            phosphatase epsilon physically associate with the adaptor molecule
CC   GPRFLN|            Grb2
CC   GPRFLN|  JOURNAL   Oncogene 18 (36), 5024-5031 (1999)
CC   GPRFLN|  MEDLINE   99422037
CC   GPRFLN|  REMARK    functional study of the mouse homolog
CC   GPRFLN|REFERENCE   7  (residues 1 to 700)
CC   GPRFLN|  AUTHORS   Elson,A. and Leder,P.
CC   GPRFLN|  TITLE     Identification of a cytoplasmic, phorbol ester-inducible isoform of
CC   GPRFLN|            protein tyrosine phosphatase epsilon
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (26), 12235-12239 (1995)
CC   GPRFLN|  MEDLINE   96109240
CC   GPRFLN|REFERENCE   8  (residues 1 to 700)
CC   GPRFLN|  AUTHORS   van den Maagdenberg,A.M., van den Hurk,H.H., Weghuis,D.,
CC   GPRFLN|            Wieringa,B., Geurts van Kessel,A. and Hendriks,W.J.
CC   GPRFLN|  TITLE     Assignment of the human protein tyrosine phosphatase epsilon
CC   GPRFLN|            (PTPRE) gene to chromosome 10q26 by fluorescence in situ
CC   GPRFLN|            hybridization
CC   GPRFLN|  JOURNAL   Genomics 30 (1), 128-129 (1995)
CC   GPRFLN|  MEDLINE   96129319
CC   GPRFLN|REFERENCE   9  (residues 1 to 700)
CC   GPRFLN|  AUTHORS   Krueger,N.X., Streuli,M. and Saito,H.
CC   GPRFLN|  TITLE     Structural diversity and evolution of human receptor-like protein
CC   GPRFLN|            tyrosine phosphatases
CC   GPRFLN|  JOURNAL   EMBO J. 9 (10), 3241-3252 (1990)
CC   GPRFLN|  MEDLINE   91006018
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    287       VNTIFKEY:269
FT   PROTEIN       1    287       protein tyrosine phosphatase, receptor type, epsilon; protein tyrosine phosphatase, receptor type, epsilon polypeptide; protein tyrosine phosphatase epsilon
FT                                VNTIFKEY:270
FT   CHAIN         1    287       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       21    286       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_2
SQ   SEQUENCE   287 AA;
     SSLEKHLQTM HGTTTHFDKI GLEEEFRKLT NVRIMKENMR TGNLPANMKK ARVIQIIPYD        60
     FNRVILSMKR GQEYTDYINA SFIDGYRQKD YFIATQGPLA HTVEDFWRMI WEWKSHTIVM       120
     LTEVQEREQD KCYQYWPTEG SVTHGEITIE IKNDTLSEAI SIRDFLVTLN QPQARQEEQV       180
     RVVRQFHFHG WPEIGIPAEG KGMIDLIAAV QKQQQQTGNH PITVHCSAGA GRTGTFIALS       240
     NILERVKAEG LLDVFQAVKS LRLQRPHMVQ TLEQYEFCYK VVQDFID                     287
//
ID   hPTPgamma_D2\(NP_002832)\PTPRG STANDARD;PRT;   283 AA.
AC   NP_002832;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, G precursor; protein tyrosine phosphatase, receptor type, gamma polypeptide; protein tyrosine phosphatase gamma; receptor-type protein phosphatase gamma; receptor tyrosine phosphatase gamma [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from L09247.1, AI872451.1 and
CC   U46089.1.
CC   On Feb 22, 2002 this sequence version replaced gi:11386169.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP possesses an extracellular
CC   region, a single transmembrane region, and two tandem
CC   intracytoplasmic catalytic domains, and thus represents a
CC   receptor-type PTP. The extracellular region of this PTP contains a
CC   carbonic anhydrase-like (CAH) domain, which is also found in the
CC   extracellular region of PTPRBETA/ZETA. This gene is located in a
CC   chromosomal region that is frequently deleted in renal cell
CC   carcinoma and lung carcinoma, thus is thought to be a candidate
CC   tumor suppressor gene.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1445)
CC   GPRFLN|  AUTHORS   Liu,S., Sugimoto,Y., Kulp,S.K., Jiang,J., Chang,H.L., Park,K.Y.,
CC   GPRFLN|            Kashida,Y. and Lin,Y.C.
CC   GPRFLN|  TITLE     Estrogenic down-regulation of protein tyrosine phosphatase gamma
CC   GPRFLN|            (PTP gamma) in human breast is associated with estrogen receptor
CC   GPRFLN|            alpha
CC   GPRFLN|  JOURNAL   Anticancer Res. 22 (6C), 3917-3923 (2002)
CC   GPRFLN|  MEDLINE   22441179
CC   GPRFLN|  REMARK    GeneRIF: Estrogenic down-regulation of protein tyrosine phosphatase
CC   GPRFLN|            gamma (PTP gamma) in human breast is associated with estrogen
CC   GPRFLN|            receptor alpha.
CC   GPRFLN|REFERENCE   2  (residues 1 to 1445)
CC   GPRFLN|  AUTHORS   Liu,S., Kulp,S.K., Sugimoto,Y., Jiang,J., Chang,H.L. and Lin,Y.C.
CC   GPRFLN|  TITLE     Involvement of breast epithelial-stromal interactions in the
CC   GPRFLN|            regulation of protein tyrosine phosphatase-gamma (PTPgamma) mRNA
CC   GPRFLN|            expression by estrogenically active agents
CC   GPRFLN|  JOURNAL   Breast Cancer Res. Treat. 71 (1), 21-35 (2002)
CC   GPRFLN|  MEDLINE   21848634
CC   GPRFLN|  REMARK    GeneRIF: both estradiol-17beta and zeranol regulate PTPgamma
CC   GPRFLN|            expression in human breast; epithelial-stromal cell interaction is
CC   GPRFLN|            important in regulation of PTPgamma expression by estrogenically
CC   GPRFLN|            active agents
CC   GPRFLN|REFERENCE   3  (residues 1 to 1445)
CC   GPRFLN|  AUTHORS   Kastury,K., Ohta,M., Lasota,J., Moir,D., Dorman,T., LaForgia,S.,
CC   GPRFLN|            Druck,T. and Huebner,K.
CC   GPRFLN|  TITLE     Structure of the human receptor tyrosine phosphatase gamma gene
CC   GPRFLN|            (PTPRG) and relation to the familial RCC t(3;8) chromosome
CC   GPRFLN|            translocation
CC   GPRFLN|  JOURNAL   Genomics 32 (2), 225-235 (1996)
CC   GPRFLN|  MEDLINE   96429999
CC   GPRFLN|REFERENCE   4  (residues 1 to 1445)
CC   GPRFLN|  AUTHORS   Barnea,G., Silvennoinen,O., Shaanan,B., Honegger,A.M., Canoll,P.D.,
CC   GPRFLN|            D'Eustachio,P., Morse,B., Levy,J.B., Laforgia,S., Huebner,K. et al.
CC   GPRFLN|  TITLE     Identification of a carbonic anhydrase-like domain in the
CC   GPRFLN|            extracellular region of RPTP gamma defines a new subfamily of
CC   GPRFLN|            receptor tyrosine phosphatases
CC   GPRFLN|  JOURNAL   Mol. Cell. Biol. 13 (3), 1497-1506 (1993)
CC   GPRFLN|  MEDLINE   93180796
CC   GPRFLN|REFERENCE   5  (residues 1 to 1445)
CC   GPRFLN|  AUTHORS   LaForgia,S., Morse,B., Levy,J., Barnea,G., Cannizzaro,L.A., Li,F.,
CC   GPRFLN|            Nowell,P.C., Boghosian-Sell,L., Glick,J., Weston,A. et al.
CC   GPRFLN|  TITLE     Receptor protein-tyrosine phosphatase gamma is a candidate tumor
CC   GPRFLN|            suppressor gene at human chromosome region 3p21
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 88 (11), 5036-5040 (1991)
CC   GPRFLN|  MEDLINE   91271326
CC   GPRFLN|REFERENCE   6  (residues 1 to 1445)
CC   GPRFLN|  AUTHORS   Krueger,N.X., Streuli,M. and Saito,H.
CC   GPRFLN|  TITLE     Structural diversity and evolution of human receptor-like protein
CC   GPRFLN|            tyrosine phosphatases
CC   GPRFLN|  JOURNAL   EMBO J. 9 (10), 3241-3252 (1990)
CC   GPRFLN|  MEDLINE   91006018
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    283       VNTIFKEY:269
FT   PROTEIN       1    283       protein tyrosine phosphatase, receptor type, gamma polypeptide; protein tyrosine phosphatase gamma; receptor-type protein phosphatase gamma; receptor tyrosine phosphatase gamma
FT                                VNTIFKEY:270
FT   CHAIN         1    283       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       21    283       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_3
SQ   SEQUENCE   283 AA;
     NQLHSYVNSI LIPGVGGKTR LEKQFKLVTQ CNAKYVECFS AQKECNKEKN RNSSVVPSER        60
     ARVGLAPLPG MKGTDYINAS YIMGYYRSNE FIITQHPLPH TTKDFWRMIW DHNAQIIVML       120
     PDNQSLAEDE FVYWPSREES MNCEAFTVTL ISKDRLCLSN EEQIIIHDFI LEATQDDYVL       180
     EVRHFQCPKW PNPDAPISST FELINVIKEE ALTRDGPTIV HDEYGAVSAG MLCALTTLSQ       240
     QLENENAVDV FQVAKMINLM RPGVFTDIEQ YQFIYKARLS LVS                         283
//
ID   hPTPkappa_D2\(NP_002835)\PTPRK STANDARD;PRT;   283 AA.
AC   NP_002835;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, K precursor; protein-tyrosine phosphatase, receptor type, kappa; protein-tyrosine phosphatase kappa; protein-tyrosine phosphatase kappa precursor [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from L77886.1 and BI755683.1.
CC   On Feb 22, 2002 this sequence version replaced gi:4506317.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP possesses an extracellular
CC   region, a single transmembrane region, and two tandem catalytic
CC   domains, and thus represents a receptor-type PTP. The extracellular
CC   region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like
CC   domain and four fibronectin type III-like repeats. This PTP was
CC   shown to mediate homophilic intercellular interaction, possibly
CC   through the interaction with beta- and gamma-catenin at adherens
CC   junctions. Expression of this gene was found to be stimulated by
CC   TGF-beta 1, which may be important for the inhibition of
CC   keratinocyte proliferation.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1440)
CC   GPRFLN|  AUTHORS   Yang,Y., Gil,M.C., Choi,E.Y., Park,S.H., Pyun,K.H. and Ha,H.
CC   GPRFLN|  TITLE     Molecular cloning and chromosomal localization of a human gene
CC   GPRFLN|            homologous to the murine R-PTP-kappa, a receptor-type protein
CC   GPRFLN|            tyrosine phosphatase
CC   GPRFLN|  JOURNAL   Gene 186 (1), 77-82 (1997)
CC   GPRFLN|  MEDLINE   97199372
CC   GPRFLN|REFERENCE   2  (residues 1 to 1440)
CC   GPRFLN|  AUTHORS   Yang,Y., Gil,M., Byun,S.M., Choi,I., Pyun,K.H. and Ha,H.
CC   GPRFLN|  TITLE     Transforming growth factor-beta1 inhibits human keratinocyte
CC   GPRFLN|            proliferation by upregulation of a receptor-type tyrosine
CC   GPRFLN|            phosphatase R-PTP-kappa gene expression
CC   GPRFLN|  JOURNAL   Biochem. Biophys. Res. Commun. 228 (3), 807-812 (1996)
CC   GPRFLN|  MEDLINE   97096334
CC   GPRFLN|REFERENCE   3  (residues 1 to 1440)
CC   GPRFLN|  AUTHORS   Fuchs,M., Muller,T., Lerch,M.M. and Ullrich,A.
CC   GPRFLN|  TITLE     Association of human protein-tyrosine phosphatase kappa with
CC   GPRFLN|            members of the armadillo family
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 271 (28), 16712-16719 (1996)
CC   GPRFLN|  MEDLINE   96279245
CC   GPRFLN|REFERENCE   4  (residues 1 to 1440)
CC   GPRFLN|  AUTHORS   Zondag,G.C., Koningstein,G.M., Jiang,Y.P., Sap,J., Moolenaar,W.H.
CC   GPRFLN|            and Gebbink,M.F.
CC   GPRFLN|  TITLE     Homophilic interactions mediated by receptor tyrosine phosphatases
CC   GPRFLN|            mu and kappa. A critical role for the novel extracellular MAM
CC   GPRFLN|            domain
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 270 (24), 14247-14250 (1995)
CC   GPRFLN|  MEDLINE   95301498
CC   GPRFLN|REFERENCE   5  (residues 1 to 1440)
CC   GPRFLN|  AUTHORS   Sap,J., Jiang,Y.P., Friedlander,D., Grumet,M. and Schlessinger,J.
CC   GPRFLN|  TITLE     Receptor tyrosine phosphatase R-PTP-kappa mediates homophilic
CC   GPRFLN|            binding
CC   GPRFLN|  JOURNAL   Mol. Cell. Biol. 14 (1), 1-9 (1994)
CC   GPRFLN|  MEDLINE   94088505
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    283       VNTIFKEY:269
FT   PROTEIN       1    283       protein-tyrosine phosphatase, receptor type, kappa; protein-tyrosine phosphatase kappa; protein-tyrosine phosphatase kappa precursor
FT                                VNTIFKEY:270
FT   CHAIN         1    283       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       19    283       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_3
SQ   SEQUENCE   283 AA;
     KAAYFDMIRI DSQTNSSHLK DEFQTLNSVT PRLQAEDCSI ACLPRNHDKN RFMDMLPPDR        60
     CLPFLITIDG ESSNYINAAL MDSYRQPAAF IVTQYPLPNT VKDFWRLVYD YGCTSIVMLN       120
     EVDLSQGCPQ YWPEEGMLRY GPIQVECMSC SMDCDVINRI FRICNLTRPQ EGYLMVQQFQ       180
     YLGWASHREV PGSKRSFLKL ILQVEKWQEE CEEGEGRTII HCLNGGGRSG MFCAIGIVVE       240
     MVKRQNVVDV FHAVKTLRNS KPNMVEAPEQ YRFCYDVALE YLE                         283
//
ID   hPTPlamda_D2\(NP_005695)\PTPRU STANDARD;PRT;   284 AA.
AC   NP_005695;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, U isoform 3 precursor; protein tyrosine phosphatase J; protein tyrosine phosphatase receptor omicron [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from X97198.1 and X95712.1.
CC   On Mar 26, 2002 this sequence version replaced gi:5032003.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP possesses an extracellular
CC   region, a single transmembrane region, and two tandem intracellular
CC   catalytic domains, and thus represents a receptor-type PTP. The
CC   extracellular region contains a meprin-A5 antigen-PTP (MAM) domain,
CC   Ig-like and fibronectin type III-like repeats. This PTP was thought
CC   to play roles in cell-cell recognition and adhesion. Studies of the
CC   similar gene in mice suggested the role of this PTP in early neural
CC   development. The expression of this gene was reported to be
CC   regulated by phorbol myristate acetate (PMA) or calcium ionophore
CC   in Jurkat T lymphoma cells. Three alternatively spliced transcript
CC   variants, which encode distinct proteins, have been reported.
CC   
CC   Transcript Variant: This variant (3) encodes the longest isoform
CC   (3).
CC   GPRFLN|REFERENCE   1  (residues 1 to 1446)
CC   GPRFLN|  AUTHORS   Yan,H.X., He,Y.Q., Dong,H., Zhang,P., Zeng,J.Z., Cao,H.F., Wu,M.C.
CC   GPRFLN|            and Wang,H.Y.
CC   GPRFLN|  TITLE     Physical and functional interaction between receptor-like protein
CC   GPRFLN|            tyrosine phosphatase PCP-2 and beta-catenin
CC   GPRFLN|  JOURNAL   Biochemistry 41 (52), 15854-15860 (2002)
CC   GPRFLN|  MEDLINE   22389441
CC   GPRFLN|  REMARK    GeneRIF: Expressed in a cell density-dependent fashion, PCP-2
CC   GPRFLN|            interacts directly with its substrate beta-catenin, independent of
CC   GPRFLN|            the tyrosine phosphorylation state of beta-catenin.
CC   GPRFLN|REFERENCE   2  (residues 1 to 1446)
CC   GPRFLN|  AUTHORS   Wang,B., Kishihara,K., Zhang,D., Sakamoto,T. and Nomoto,K.
CC   GPRFLN|  TITLE     Transcriptional regulation of a receptor protein tyrosine
CC   GPRFLN|            phosphatase gene hPTP-J by PKC-mediated signaling pathways in
CC   GPRFLN|            Jurkat and Molt-4 T lymphoma cells
CC   GPRFLN|  JOURNAL   Biochim. Biophys. Acta 1450 (3), 331-340 (1999)
CC   GPRFLN|  MEDLINE   99326162
CC   GPRFLN|REFERENCE   3  (residues 1 to 1446)
CC   GPRFLN|  AUTHORS   Avraham,S., London,R., Tulloch,G.A., Ellis,M., Fu,Y., Jiang,S.,
CC   GPRFLN|            White,R.A., Painter,C., Steinberger,A.A. and Avraham,H.
CC   GPRFLN|  TITLE     Characterization and chromosomal localization of PTPRO, a novel
CC   GPRFLN|            receptor protein tyrosine phosphatase, expressed in hematopoietic
CC   GPRFLN|            stem cells
CC   GPRFLN|  JOURNAL   Gene 204 (1-2), 5-16 (1997)
CC   GPRFLN|  MEDLINE   98094249
CC   GPRFLN|REFERENCE   4  (residues 1 to 1446)
CC   GPRFLN|  AUTHORS   Wang,B., Kishihara,K., Zhang,D., Hara,H. and Nomoto,K.
CC   GPRFLN|  TITLE     Molecular cloning and characterization of a novel human receptor
CC   GPRFLN|            protein tyrosine phosphatase gene, hPTP-J: down-regulation of gene
CC   GPRFLN|            expression by PMA and calcium ionophore in Jurkat T lymphoma cells
CC   GPRFLN|  JOURNAL   Biochem. Biophys. Res. Commun. 231 (1), 77-81 (1997)
CC   GPRFLN|  MEDLINE   97223402
CC   GPRFLN|REFERENCE   5  (residues 1 to 1446)
CC   GPRFLN|  AUTHORS   Crossland,S., Smith,P.D. and Crompton,M.R.
CC   GPRFLN|  TITLE     Molecular cloning and characterization of PTP pi, a novel
CC   GPRFLN|            receptor-like protein-tyrosine phosphatase
CC   GPRFLN|  JOURNAL   Biochem. J. 319 (Pt 1), 249-254 (1996)
CC   GPRFLN|  MEDLINE   97024447
CC   GPRFLN|REFERENCE   6  (residues 1 to 1446)
CC   GPRFLN|  AUTHORS   Wang,H., Lian,Z., Lerch,M.M., Chen,Z., Xie,W. and Ullrich,A.
CC   GPRFLN|  TITLE     Characterization of PCP-2, a novel receptor protein tyrosine
CC   GPRFLN|            phosphatase of the MAM domain family
CC   GPRFLN|  JOURNAL   Oncogene 12 (12), 2555-2562 (1996)
CC   GPRFLN|  MEDLINE   96293401
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    284       VNTIFKEY:269
FT   PROTEIN       1    284       protein tyrosine phosphatase J; protein tyrosine phosphatase receptor omicron
FT                                VNTIFKEY:270
FT   CHAIN         1    284       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       18    284       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_3
SQ   SEQUENCE   284 AA;
     KATYKEMIRI DPQSNSSQLR EEFQTLNSVT PPLDVEECSI ALLPRNRDKN RSMDVLPPDR        60
     CLPFLISTDG DSNNYINAAL TDSYTRSAAF IVTLHPLQST TPDFWRLVYD YGCTSIVMLN       120
     QLNQSNSAWP CLQYWPEPGR QQYGLMEVEF MSGTADEDLV ARVFRVQNIS RLQEGHLLVR       180
     HFQFLRWSAY RDTPDSKKAF LHLLAEVDKW QAESGDGRTI VHCLNGGGRS GTFCACATVL       240
     EMIRCHNLVD VFFAAKTLRN YKPNMVETMD QYHFCYDVAL EYLE                        284
//
ID   hPTPmu_D2\(NP_002836)\PTPRM STANDARD;PRT;   283 AA.
AC   NP_002836;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, M precursor; protein tyrosine phosphatase, receptor type, mu polypeptide; protein tyrosine phosphatase mu precursor [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from X58288.1 and AA281524.1.
CC   On Feb 22, 2002 this sequence version replaced gi:4506319.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP possesses an extracellular
CC   region, a single transmembrane region, and two tandem catalytic
CC   domains, and thus represents a receptor-type PTP. The extracellular
CC   region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like
CC   domain and four fibronectin type III-like repeats. This PTP has
CC   been shown to mediate cell-cell aggregation through the interaction
CC   with another molecule of this PTP on an adjacent cell. This PTP can
CC   interact with scaffolding protein RACK1/GNB2L1, which may be
CC   necessary for the downstream signaling in response to cell-cell
CC   adhesion.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1452)
CC   GPRFLN|  AUTHORS   Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J.
CC   GPRFLN|  TITLE     Intra- and intermolecular interactions between intracellular
CC   GPRFLN|            domains of receptor protein-tyrosine phosphatases
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (49), 47263-47269 (2002)
CC   GPRFLN|  MEDLINE   22344739
CC   GPRFLN|  REMARK    GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are
CC   GPRFLN|            a common but specific mechanism that is likely to be regulated-
CC   GPRFLN|            domain2s and the wedge structures are crucial determinants of
CC   GPRFLN|            binding specificity, thus regulating cross-talk between RPTPs
CC   GPRFLN|REFERENCE   2  (residues 1 to 1452)
CC   GPRFLN|  AUTHORS   Mourton,T., Hellberg,C.B., Burden-Gulley,S.M., Hinman,J., Rhee,A.
CC   GPRFLN|            and Brady-Kalnay,S.M.
CC   GPRFLN|  TITLE     The PTPmu protein-tyrosine phosphatase binds and recruits the
CC   GPRFLN|            scaffolding protein RACK1 to cell-cell contacts
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 276 (18), 14896-14901 (2001)
CC   GPRFLN|  MEDLINE   21226727
CC   GPRFLN|REFERENCE   3  (residues 1 to 1452)
CC   GPRFLN|  AUTHORS   Feiken,E., van Etten,I., Gebbink,M.F., Moolenaar,W.H. and
CC   GPRFLN|            Zondag,G.C.
CC   GPRFLN|  TITLE     Intramolecular interactions between the juxtamembrane domain and
CC   GPRFLN|            phosphatase domains of receptor protein-tyrosine phosphatase
CC   GPRFLN|            RPTPmu. Regulation of catalytic activity
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 275 (20), 15350-15356 (2000)
CC   GPRFLN|  MEDLINE   20270248
CC   GPRFLN|REFERENCE   4  (residues 1 to 1452)
CC   GPRFLN|  AUTHORS   Brady-Kalnay,S.M. and Tonks,N.K.
CC   GPRFLN|  TITLE     Identification of the homophilic binding site of the receptor
CC   GPRFLN|            protein tyrosine phosphatase PTP mu
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 269 (45), 28472-28477 (1994)
CC   GPRFLN|  MEDLINE   95050637
CC   GPRFLN|REFERENCE   5  (residues 1 to 1452)
CC   GPRFLN|  AUTHORS   Suijkerbuijk,R.F., Gebbink,M.F., Moolenaar,W.H. and Geurts van
CC   GPRFLN|            Kessel,A.
CC   GPRFLN|  TITLE     Fine mapping of the human receptor-like protein tyrosine
CC   GPRFLN|            phosphatase gene (PTPRM) to 18p11.2 by fluorescence in situ
CC   GPRFLN|            hybridization
CC   GPRFLN|  JOURNAL   Cytogenet. Cell Genet. 64 (3-4), 245-246 (1993)
CC   GPRFLN|  MEDLINE   94007972
CC   GPRFLN|REFERENCE   6  (residues 1 to 1452)
CC   GPRFLN|  AUTHORS   Brady-Kalnay,S.M., Flint,A.J. and Tonks,N.K.
CC   GPRFLN|  TITLE     Homophilic binding of PTP mu, a receptor-type protein tyrosine
CC   GPRFLN|            phosphatase, can mediate cell-cell aggregation
CC   GPRFLN|  JOURNAL   J. Cell Biol. 122 (4), 961-972 (1993)
CC   GPRFLN|  MEDLINE   93352709
CC   GPRFLN|REFERENCE   7  (residues 1 to 1452)
CC   GPRFLN|  AUTHORS   Gebbink,M.F., van Etten,I., Hateboer,G., Suijkerbuijk,R.,
CC   GPRFLN|            Beijersbergen,R.L., Geurts van Kessel,A. and Moolenaar,W.H.
CC   GPRFLN|  TITLE     Cloning, expression and chromosomal localization of a new putative
CC   GPRFLN|            receptor-like protein tyrosine phosphatase
CC   GPRFLN|  JOURNAL   FEBS Lett. 290 (1-2), 123-130 (1991)
CC   GPRFLN|  MEDLINE   92008644
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    283       VNTIFKEY:269
FT   PROTEIN       1    283       protein tyrosine phosphatase, receptor type, mu polypeptide; protein tyrosine phosphatase mu precursor
FT                                VNTIFKEY:270
FT   CHAIN         1    283       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       18    282       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_3
SQ   SEQUENCE   283 AA;
     RSLYYDMNKL DPQTNSSQIK EEFRTLNMVT PTLRVEDCSI ALLPRNHEKN RCMDILPPDR        60
     CLPFLITIDG ESSNYINAAL MDSYKQPSAF IVTQHPLPNT VKDFWRLVLD YHCTSVVMLN       120
     DVDPAQLCPQ YWPENGVHRH GPIQVEFVSA DLEEDIISRI FRIYNAARPQ DGYRMVQQFQ       180
     FLGWPMYRDT PVSKRSFLKL IRQVDKWQEE YNGGEGPTVV HCLNGGGRSG TFCAISIVCE       240
     MLRHQRTVDV FHAVKTLRNN KPNMVDLLDQ YKFCYEVALE YLN                         283
//
ID   hPTPrho_D2\(NP_573400)\PTPRT STANDARD;PRT;   283 AA.
AC   NP_573400;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, T isoform 1 precursor; receptor protein tyrosine phosphatase [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from AF043644.4 and R50970.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP possesses an extracellular
CC   region, a single transmembrane region, and two tandem intracellular
CC   catalytic domains, and thus represents a receptor-type PTP. The
CC   extracellular region contains a meprin-A5 antigen-PTP (MAM) domain,
CC   Ig-like and fibronectin type III-like repeats. The protein domain
CC   structure and the expression pattern of the mouse counterpart of
CC   this PTP suggest its roles in both signal transduction and cellular
CC   adhesion in the central nervous system. Two alternatively spliced
CC   transcript variants of this gene, which encode distinct proteins,
CC   have been reported.
CC   
CC   Transcript Variant: This variant (1) contains an additional
CC   fragment within the coding region when compared to variant 2, and
CC   thus encodes a protein that contains an extra internal segment, as
CC   compared to isoform 2.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1463)
CC   GPRFLN|  AUTHORS   Besco,J.A., Frostholm,A., Popesco,M.C., Burghes,A.H. and Rotter,A.
CC   GPRFLN|  TITLE     Genomic organization and alternative splicing of the human and
CC   GPRFLN|            mouse RPTPrho genes
CC   GPRFLN|  JOURNAL   BMC Genomics 2 (1), 1 (2001)
CC   GPRFLN|REFERENCE   2  (residues 1 to 1463)
CC   GPRFLN|  AUTHORS   McAndrew,P.E., Frostholm,A., White,R.A., Rotter,A. and Burghes,A.H.
CC   GPRFLN|  TITLE     Identification and characterization of RPTP rho, a novel RPTP
CC   GPRFLN|            mu/kappa-like receptor protein tyrosine phosphatase whose
CC   GPRFLN|            expression is restricted to the central nervous system
CC   GPRFLN|  JOURNAL   Brain Res. Mol. Brain Res. 56 (1-2), 9-21 (1998)
CC   GPRFLN|  MEDLINE   98267260
CC   GPRFLN|REFERENCE   3  (residues 1 to 1463)
CC   GPRFLN|  AUTHORS   McAndrew,P.E., Frostholm,A., Evans,J.E., Zdilar,D., Goldowitz,D.,
CC   GPRFLN|            Chiu,I.M., Burghes,A.H. and Rotter,A.
CC   GPRFLN|  TITLE     Novel receptor protein tyrosine phosphatase (RPTPrho) and acidic
CC   GPRFLN|            fibroblast growth factor (FGF-1) transcripts delineate a
CC   GPRFLN|            rostrocaudal boundary in the granule cell layer of the murine
CC   GPRFLN|            cerebellar cortex
CC   GPRFLN|  JOURNAL   J. Comp. Neurol. 391 (4), 444-455 (1998)
CC   GPRFLN|  MEDLINE   98146229
CC   GPRFLN|REFERENCE   4  (residues 1 to 1463)
CC   GPRFLN|  AUTHORS   Hillier,L.D., Lennon,G., Becker,M., Bonaldo,M.F., Chiapelli,B.,
CC   GPRFLN|            Chissoe,S., Dietrich,N., DuBuque,T., Favello,A., Gish,W.,
CC   GPRFLN|            Hawkins,M., Hultman,M., Kucaba,T., Lacy,M., Le,M., Le,N.,
CC   GPRFLN|            Mardis,E., Moore,B., Morris,M., Parsons,J., Prange,C., Rifkin,L.,
CC   GPRFLN|            Rohlfing,T., Schellenberg,K., Marra,M. et al.
CC   GPRFLN|  TITLE     Generation and analysis of 280,000 human expressed sequence tags
CC   GPRFLN|  JOURNAL   Genome Res. 6 (9), 807-828 (1996)
CC   GPRFLN|  MEDLINE   97044478
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    283       VNTIFKEY:269
FT   PROTEIN       1    283       receptor protein tyrosine phosphatase
FT                                VNTIFKEY:270
FT   CHAIN         1    283       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       18    283       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_2
SQ   SEQUENCE   283 AA;
     RSLYYNISRL DPQTNSSQIK DEFQTLNIVT PRVRPEDCSI GLLPRNHDKN RSMDVLPLDR        60
     CLPFLISVDG ESSNYINAAL MDSHKQPAAF VVTQHPLPNT VADFWRLVFD YNCSSVVMLN       120
     EMDTAQFCMQ YWPEKTSGCY GPIQVEFVSA DIDEDIIHRI FRICNMARPQ DGYRIVQHLQ       180
     YIGWPAYRDT PPSKRSLLKV VRRLEKWQEQ YDGREGRTVV HCLNGGGRSG TFCAICSVCE       240
     MIQQQNIIDV FHIVKTLRNN KSNMVETLEQ YKFVYEVALE YLS                         283
//
ID   hPTPsigma_D2\(NP_002841)\PTPRS STANDARD;PRT;   283 AA.
AC   NP_002841;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, sigma isoform 1 precursor; protein tyrosine phosphatase PTPsigma [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from U35234.1 and BI461316.1.
CC   On Mar 26, 2002 this sequence version replaced gi:4506327.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP contains an extracellular
CC   region, a single transmembrane segment and two tandem
CC   intracytoplasmic catalytic domains, and thus represents a
CC   receptor-type PTP. The extracellular region of this protein is
CC   composed of multiple Ig-like and fibronectin type III-like domains.
CC   Studies of the similar gene in mice suggested that this PTP may be
CC   involved in cell-cell interaction, primary axonogenesis, and axon
CC   guidance during embryogenesis. This PTP has been also implicated in
CC   the molecular control of adult nerve repair. Four alternatively
CC   spliced transcript variants, which encode distinct proteins, have
CC   been reported.
CC   
CC   Transcript Variant: This variant (1) encodes the longest isoform
CC   (1).
CC   GPRFLN|REFERENCE   1  (residues 1 to 1948)
CC   GPRFLN|  AUTHORS   Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J.
CC   GPRFLN|  TITLE     Intra- and intermolecular interactions between intracellular
CC   GPRFLN|            domains of receptor protein-tyrosine phosphatases
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (49), 47263-47269 (2002)
CC   GPRFLN|  MEDLINE   22344739
CC   GPRFLN|  REMARK    GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are
CC   GPRFLN|            a common but specific mechanism that is likely to be regulated-
CC   GPRFLN|            domain2s and the wedge structures are crucial determinants of
CC   GPRFLN|            binding specificity, thus regulating cross-talk between RPTPs
CC   GPRFLN|REFERENCE   2  (residues 1 to 1948)
CC   GPRFLN|  AUTHORS   Wallace,M.J., Batt,J., Fladd,C.A., Henderson,J.T., Skarnes,W. and
CC   GPRFLN|            Rotin,D.
CC   GPRFLN|  TITLE     Neuronal defects and posterior pituitary hypoplasia in mice lacking
CC   GPRFLN|            the receptor tyrosine phosphatase PTPsigma
CC   GPRFLN|  JOURNAL   Nat. Genet. 21 (3), 334-338 (1999)
CC   GPRFLN|  MEDLINE   99178277
CC   GPRFLN|  REMARK    functional study of the mouse homolog
CC   GPRFLN|REFERENCE   3  (residues 1 to 1948)
CC   GPRFLN|  AUTHORS   Elchebly,M., Wagner,J., Kennedy,T.E., Lanctot,C., Michaliszyn,E.,
CC   GPRFLN|            Itie,A., Drouin,J. and Tremblay,M.L.
CC   GPRFLN|  TITLE     Neuroendocrine dysplasia in mice lacking protein tyrosine
CC   GPRFLN|            phosphatase sigma
CC   GPRFLN|  JOURNAL   Nat. Genet. 21 (3), 330-333 (1999)
CC   GPRFLN|  MEDLINE   99178276
CC   GPRFLN|  REMARK    functional study of the mouse homolog
CC   GPRFLN|REFERENCE   4  (residues 1 to 1948)
CC   GPRFLN|  AUTHORS   Haworth,K., Shu,K.K., Stokes,A., Morris,R. and Stoker,A.
CC   GPRFLN|  TITLE     The expression of receptor tyrosine phosphatases is responsive to
CC   GPRFLN|            sciatic nerve crush
CC   GPRFLN|  JOURNAL   Mol. Cell. Neurosci. 12 (3), 93-104 (1998)
CC   GPRFLN|  MEDLINE   99009170
CC   GPRFLN|  REMARK    functional study of the rat homolog
CC   GPRFLN|REFERENCE   5  (residues 1 to 1948)
CC   GPRFLN|  AUTHORS   Wagner,J., Gordon,L.A., Heng,H.H., Tremblay,M.L. and Olsen,A.S.
CC   GPRFLN|  TITLE     Physical mapping of receptor type protein tyrosine phosphatase
CC   GPRFLN|            sigma (PTPRS) to human chromosome 19p13.3
CC   GPRFLN|  JOURNAL   Genomics 38 (1), 76-78 (1996)
CC   GPRFLN|  MEDLINE   97124849
CC   GPRFLN|REFERENCE   6  (residues 1 to 1948)
CC   GPRFLN|  AUTHORS   Endo,N., Rutledge,S.J., Opas,E.E., Vogel,R., Rodan,G.A. and
CC   GPRFLN|            Schmidt,A.
CC   GPRFLN|  TITLE     Human protein tyrosine phosphatase-sigma: alternative splicing and
CC   GPRFLN|            inhibition by bisphosphonates
CC   GPRFLN|  JOURNAL   J. Bone Miner. Res. 11 (4), 535-543 (1996)
CC   GPRFLN|  MEDLINE   96255038
CC   GPRFLN|REFERENCE   7  (residues 1 to 1948)
CC   GPRFLN|  AUTHORS   Pulido,R., Serra-Pages,C., Tang,M. and Streuli,M.
CC   GPRFLN|  TITLE     The LAR/PTP delta/PTP sigma subfamily of transmembrane
CC   GPRFLN|            protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and
CC   GPRFLN|            PTP sigma isoforms are expressed in a tissue-specific manner and
CC   GPRFLN|            associate with the LAR-interacting protein LIP.1
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (25), 11686-11690 (1995)
CC   GPRFLN|  MEDLINE   96102179
CC   GPRFLN|REFERENCE   8  (residues 1 to 1948)
CC   GPRFLN|  AUTHORS   Adachi,M., Sekiya,M., Arimura,Y., Takekawa,M., Itoh,F., Hinoda,Y.,
CC   GPRFLN|            Imai,K. and Yachi,A.
CC   GPRFLN|  TITLE     Protein-tyrosine phosphatase expression in pre-B cell NALM-6
CC   GPRFLN|  JOURNAL   Cancer Res. 52 (3), 737-740 (1992)
CC   GPRFLN|  MEDLINE   92119637
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    283       VNTIFKEY:269
FT   PROTEIN       1    283       protein tyrosine phosphatase PTPsigma
FT                                VNTIFKEY:270
FT   CHAIN         1    283       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       21    282       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_5
SQ   SEQUENCE   283 AA;
     RSLYAYIQKL AQVEPGEHVT GMELEFKRLA NSKAHTSRFI SANLPCNKFK NRLVNIMPYE        60
     STRVCLQPIR GVEGSDYINA SFIDGYRQQK AYIATQGPLA ETTEDFWRML WENNSTIVVM       120
     LTKLREMGRE KCHQYWPAER SARYQYFVVD PMAEYNMPQY ILREFKVTDA RDGQSRTVRQ       180
     FQFTDWPEQG VPKSGEGFID FIGQVHKTKE QFGQDGPISV HCSAGVGRTG VFITLSIVLE       240
     RMRYEGVVDI FQTVKMLRTQ RPAMVQTEDE YQFCYQAALE YLG                         283
//
ID   hPTPzeta_D2\(NP_002842)\PTPRZ1 STANDARD;PRT;   282 AA.
AC   NP_002842;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor-type, Z polypeptide 1; protein tyrosine phosphatase, receptor-type, zeta polypeptide 1; receptor-type tyrosine phosphatase beta/zeta [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   PROVISIONAL REFSEQ: This record has not yet been subject to final
CC   NCBI review. The reference sequence was derived from M93426.1.
CC   GPRFLN|REFERENCE   1  (residues 1 to 2314)
CC   GPRFLN|  AUTHORS   Harroch,S., Furtado,G.C., Brueck,W., Rosenbluth,J., Lafaille,J.,
CC   GPRFLN|            Chao,M., Buxbaum,J.D. and Schlessinger,J.
CC   GPRFLN|  TITLE     A critical role for the protein tyrosine phosphatase receptor type
CC   GPRFLN|            Z in functional recovery from demyelinating lesions
CC   GPRFLN|  JOURNAL   Nat. Genet. 32 (3), 411-414 (2002)
CC   GPRFLN|  MEDLINE   22297719
CC   GPRFLN|  REMARK    GeneRIF: PTPRZ1 has a role in oligodendrocyte survival and in
CC   GPRFLN|            recovery from demyelinating disease
CC   GPRFLN|REFERENCE   2  (residues 1 to 2314)
CC   GPRFLN|  AUTHORS   Thomaidou,D., Coquillat,D., Meintanis,S., Noda,M., Rougon,G. and
CC   GPRFLN|            Matsas,R.
CC   GPRFLN|  TITLE     Soluble forms of NCAM and F3 neuronal cell adhesion molecules
CC   GPRFLN|            promote Schwann cell migration: identification of protein tyrosine
CC   GPRFLN|            phosphatases zeta/beta as the putative F3 receptors on Schwann
CC   GPRFLN|            cells
CC   GPRFLN|  JOURNAL   J. Neurochem. 78 (4), 767-778 (2001)
CC   GPRFLN|  MEDLINE   21412137
CC   GPRFLN|REFERENCE   3  (residues 1 to 2314)
CC   GPRFLN|  AUTHORS   Kawachi,H., Fujikawa,A., Maeda,N. and Noda,M.
CC   GPRFLN|  TITLE     Identification of GIT1/Cat-1 as a substrate molecule of protein
CC   GPRFLN|            tyrosine phosphatase zeta /beta by the yeast substrate-trapping
CC   GPRFLN|            system
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 98 (12), 6593-6598 (2001)
CC   GPRFLN|  MEDLINE   21287250
CC   GPRFLN|REFERENCE   4  (residues 1 to 2314)
CC   GPRFLN|  AUTHORS   Meng,K., Rodriguez-Pena,A., Dimitrov,T., Chen,W., Yamin,M., Noda,M.
CC   GPRFLN|            and Deuel,T.F.
CC   GPRFLN|  TITLE     Pleiotrophin signals increased tyrosine phosphorylation of beta
CC   GPRFLN|            beta-catenin through inactivation of the intrinsic catalytic
CC   GPRFLN|            activity of the receptor-type protein tyrosine phosphatase
CC   GPRFLN|            beta/zeta
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 97 (6), 2603-2608 (2000)
CC   GPRFLN|  MEDLINE   20183934
CC   GPRFLN|REFERENCE   5  (residues 1 to 2314)
CC   GPRFLN|  AUTHORS   Kawachi,H., Tamura,H., Watakabe,I., Shintani,T., Maeda,N. and
CC   GPRFLN|            Noda,M.
CC   GPRFLN|  TITLE     Protein tyrosine phosphatase zeta/RPTPbeta interacts with
CC   GPRFLN|            PSD-95/SAP90 family
CC   GPRFLN|  JOURNAL   Brain Res. Mol. Brain Res. 72 (1), 47-54 (1999)
CC   GPRFLN|  MEDLINE   99453345
CC   GPRFLN|REFERENCE   6  (residues 1 to 2314)
CC   GPRFLN|  AUTHORS   Onyango,P., Lubyova,B., Gardellin,P., Kurzbauer,R. and Weith,A.
CC   GPRFLN|  TITLE     Molecular cloning and expression analysis of five novel genes in
CC   GPRFLN|            chromosome 1p36
CC   GPRFLN|  JOURNAL   Genomics 50 (2), 187-198 (1998)
CC   GPRFLN|  MEDLINE   98317532
CC   GPRFLN|REFERENCE   7  (residues 1 to 2314)
CC   GPRFLN|  AUTHORS   Ariyama,T., Hasegawa,K., Inazawa,J., Mizuno,K., Ogimoto,M.,
CC   GPRFLN|            Katagiri,T. and Yakura,H.
CC   GPRFLN|  TITLE     Assignment of the human protein tyrosine phosphatase,
CC   GPRFLN|            receptor-type, zeta (PTPRZ) gene to chromosome band 7q31.3
CC   GPRFLN|  JOURNAL   Cytogenet. Cell Genet. 70 (1-2), 52-54 (1995)
CC   GPRFLN|  MEDLINE   95254878
CC   GPRFLN|REFERENCE   8  (residues 1 to 2314)
CC   GPRFLN|  AUTHORS   Levy,J.B., Canoll,P.D., Silvennoinen,O., Barnea,G., Morse,B.,
CC   GPRFLN|            Honegger,A.M., Huang,J.T., Cannizzaro,L.A., Park,S.H., Druck,T. et
CC   GPRFLN|            al.
CC   GPRFLN|  TITLE     The cloning of a receptor-type protein tyrosine phosphatase
CC   GPRFLN|            expressed in the central nervous system
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 268 (14), 10573-10581 (1993)
CC   GPRFLN|  MEDLINE   93252948
CC   GPRFLN|REFERENCE   9  (residues 1 to 2314)
CC   GPRFLN|  AUTHORS   Krueger,N.X. and Saito,H.
CC   GPRFLN|  TITLE     A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is
CC   GPRFLN|            expressed in brain and has an N-terminal receptor domain homologous
CC   GPRFLN|            to carbonic anhydrases
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89 (16), 7417-7421 (1992)
CC   GPRFLN|  MEDLINE   92366472
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    282       VNTIFKEY:269
FT   PROTEIN       1    282       protein tyrosine phosphatase, receptor-type, zeta polypeptide 1; receptor-type tyrosine phosphatase beta/zeta
FT                                VNTIFKEY:270
FT   REGION       20    282       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_3
SQ   SEQUENCE   282 AA;
     SHIHAYVNAL LIPGPAGKTK LEKQFQLLSQ SNIQQSDYSA ALKQCNREKN RTSSIIPVER        60
     SRVGISSLSG EGTDYINASY IMGYYQSNEF IITQHPLLHT IKDFWRMIWD HNAQLVVMIP       120
     DGQNMAEDEF VYWPNKDEPI NCESFKVTLM AEEHKCLSNE EKLIIQDFIL EATQDDYVLE       180
     VRHFQCPKWP NPDSPISKTF ELISVIKEEA ANRDGPMIVH DEHGGVTAGT FCALTTLMHQ       240
     LEKENSVDVY QVAKMINLMR PGVFADIEQY QFLYKVILSL VS                          282
//