LOCUS bIA2_D1\(P 279 aa 17-MAY-2003 DEFINITION Protein-tyrosine phosphatase-like N precursor (R-PTP-N) (Islet cell autoantigen 512) (ICA512). ACCESSION P56722 DBSOURCE swissprot: locus PTPN_BOVIN, accession P56722; class: standard. created: May 30, 2000. sequence updated: May 30, 2000. annotation updated: Jun 15, 2002. xrefs: gi: 5305475, gi: 5305476 xrefs (non-sequence databases): HSSPQ06124, InterProIPR000387, InterProIPR000242, PfamPF00102, PRINTSPR00700, SMARTSM00194, PROSITEPS00383, PROSITEPS50056, PROSITEPS50055 KEYWORDS Receptor; Glycoprotein; Signal; Transmembrane. SOURCE Bos taurus (cow). ORGANISM Bos taurus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovoidea; Bovidae; Bovinae; Bos. REFERENCE 1 (residues 1 to 979) AUTHORS Hermel,J.-M., Dirkx,R. and Solimena,M. TITLE Direct Submission JOURNAL Submitted (~JUN-1999) REMARK SEQUENCE FROM N.A. REFERENCE 2 (residues 1 to 979) AUTHORS Hermel,J.M., Dirkx,R. Jr. and Solimena,M. TITLE Post-translational modifications of ICA512, a receptor tyrosine phosphatase-like protein of secretory granules JOURNAL Eur. J. Neurosci. 11 (8), 2609-2620 (1999) MEDLINE 99388259 REMARK SEQUENCE OF N-TERMINUS, AND CHARACTERIZATION. COMMENT ------------------------------------------------------------------- This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. The original entry is available from http://www.expasy.ch/sprot and http://www.ebi.ac.uk/sprot ------------------------------------------------------------------. [FUNCTION] Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Lacks intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2 (By similarity). [SUBUNIT] Interacts with phosphorylated SNTB2, protecting it from protein cleavage by CAPN1. Dephosphorylation of SNTB2 upon insulin stimulation disrupts the interaction and results in its cleavage (By similarity). [SUBCELLULAR LOCATION] Type I membrane protein. Neuroendocrine secretory granules. [PTM] N-glycosylated. [SIMILARITY] CONTAINS 1 PROTEIN-TYROSINE PHOSPHATASE DOMAIN. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302454273| COMMENT VNTNAME|bIA2_D1 (P56722) PTPRN| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..279 /organism="Bos taurus" /db_xref="taxon:9913" /vntifkey="269" Protein 1..279 /gene="PTPRN" /product="Protein-tyrosine phosphatase-like N precursor" /vntifkey="270" Region 1..279 /gene="PTPRN" /region_name="Mature chain" /vntifkey="203" /label=PTPRN /note="PROTEIN-TYROSINE PHOSPHATASE-LIKE N." Region 1..279 /gene="PTPRN" /region_name="Domain" /vntifkey="1004" /label=PTPRN /note="CYTOPLASMIC (POTENTIAL)." Region 4..279 /gene="PTPRN" /region_name="Domain" /vntifkey="1000" /label=PTPRN /note="PROTEIN-TYROSINE PHOSPHATASE-LIKE." Site 217..217 /gene="PTPRN" /site_type="active" /vntifkey="220" /label=PTPRN /note="BY SIMILARITY." ORIGIN 1 hmilaymedh lrnrdrlake wqalcayqae pntcataqge gnikknrhpd flpydharik 61 lkvesspsrs dyinaspiie hdprmpayia tqgplshtia dfwqmvwesg ctvivmltpl 121 vedgvkqcdr ywpdegssly hvyevnlvse hiwcedflvr sfylknvqtq etrtltqfhf 181 lswpaegtpa strplldfrr kvnkcyrgrs cpiivhcsdg agrtgtyili dmvlnrmakg 241 vkeidiaatl ehvrdqrpgl vrskdqfefa ltavaeevn // LOCUS bPTPBA14_D 275 aa 2-JUL-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 13 [APO-1/CD95 (Fas)-associated phosphatase] [Bos taurus]. ACCESSION NP_777015 DBSOURCE REFSEQ: accession NM_174590.1 SOURCE Bos taurus (cow). ORGANISM Bos taurus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovoidea; Bovidae; Bovinae; Bos. REFERENCE 1 (residues 1 to 2484) AUTHORS Vega,Q.C., Walton,K.M. and Dixon,J.E. TITLE Tyrosine Phosphatases and the Cytoskeleton JOURNAL Unpublished COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U20807.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|307067825| COMMENT VNTNAME|bPTPBA14_D1 (NP_777015) PTPN13| COMMENT VNTAUTHORNAME|JNA| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..275 /organism="Bos taurus" /db_xref="taxon:9913" /chromosome="6" /map="6" /vntifkey="269" Protein 1..275 /product="protein tyrosine phosphatase, non-receptor type 13 [APO-1/CD95 (Fas)-associated phosphatase]" /vntifkey="270" Region 20..274 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_2 /note="PTPc" ORIGIN 1 aklksvirml rglldqgips kelenlqelk pldqcligqt kenrrknryk nilpydatrv 61 plgdeggyin asfikipvgr eefvyiacqg plpttvgdfw qmiweqnssv iammtqeveg 121 ekikcqrywp nvlgkstmvs nrlrlalvrv qqlkgfvvra mtlediqtge vrhvshlnft 181 awpdhdtpsq pddlltfisy mrhvhrsgpi ithcsagigr sgtlicidvv lglisqdlef 241 disdlvrcmr lqrhgmvqte dqyifcyqvi lyvlt // LOCUS cCD45_D1\( 279 aa 17-MAY-2003 DEFINITION protein-tyrosine-phosphatase (EC 3.1.3.48), receptor type delta precursor - chicken. ACCESSION A54080 DBSOURCE pir: locus A54080; summary: #length 1237 #molecular-weight 139319 #checksum 1986 ; superfamily: leukocyte common antigen; leukocyte common antigen cytosolic domain homology; protein-tyrosine-phosphatase homology ; PIR dates: 02-Aug-1994 #sequence_revision 02-Aug-1994 #text_change 21-Jan-2000 . KEYWORDS phosphoprotein; phosphoric monoester hydrolase; tyrosine-specific phosphatase. SOURCE Gallus gallus (chicken). ORGANISM Gallus gallus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. REFERENCE 1 (residues 1 to 1237) AUTHORS Fang,K.S., Barker,K., Sudol,M. and Hanafusa,H. TITLE A transmembrane protein-tyrosine phosphatase contains spectrin-like repeats in its extracellular domain JOURNAL J. Biol. Chem. 269 (19), 14056-14063 (1994) MEDLINE 94245724 COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302463475| COMMENT VNTNAME|cCD45_D1 (A54080)| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..279 /organism="Gallus gallus" /db_xref="taxon:9031" /vntifkey="269" Protein 1..279 /product="protein-tyrosine-phosphatase, receptor type delta precursor" /EC_number="3.1.3.48" /vntifkey="270" Region 1..279 /region_name="domain" /vntifkey="1000" /label=LAC /note="leukocyte common antigen cytosolic domain homology #label LAC" Region 42..266 /region_name="domain" /vntifkey="1000" /label=PTP /note="protein-tyrosine-phosphatase homology #label PTP" Site 218..218 /site_type="active" /vntifkey="220" /label=Active_Site_1 /note="Cys (phosphocysteine intermediate)" Site 224..224 /site_type="binding" /vntifkey="1007" /label=Binding_1 /note="substrate phosphate (Arg)" ORIGIN 1 eklletykrk iadegrlfld efqsiprift kfpmkeakrs hnqnknryid ilpydhnrve 61 lseipgdpgs dyinasyidg fkeprkyiaa qgpkdettdd fwrmiweqka tiivmvtrce 121 egnrnkcaqy gpsmengsat ygditvkine skicpdyiiq klhitngrer tsgrdvthiq 181 ftswpdhgvp edphlllklr rrvnalsnff sgpivvhcsa gvgrtgtyig idamleglda 241 egrvdvygyv vklrrqrclm vqvesqyili hqalveyhq // LOCUS cDEP1_D1\( 277 aa 27-JUN-2003 DEFINITION supporting-cell antigen [Gallus gallus]. ACCESSION CAB41885 DBSOURCE embl locus GGA238216, accession AJ238216.2 SOURCE Gallus gallus (chicken). ORGANISM Gallus gallus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. REFERENCE 1 AUTHORS Kruger,R.P., Goodyear,R.J., Legan,P.K., Warchol,M.E., Raphael,Y., Cotanche,D.A. and Richardson,G.P. TITLE The supporting-cell antigen: a receptor-like protein tyrosine phosphatase expressed in the sensory epithelia of the avian inner ear JOURNAL J. Neurosci. 19 (12), 4815-4827 (1999) MEDLINE 99296852 REFERENCE 2 AUTHORS Legan,P.K. TITLE Direct Submission JOURNAL Submitted (26-APR-1999) Legan P.K., School of Biological Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UNITED KINGDOM REMARK Revised by [3] REFERENCE 3 (residues 1 to 1406) AUTHORS Legan,P.K. TITLE Direct Submission JOURNAL Submitted (27-JUN-2001) Legan P.K., School of Biological Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UNITED KINGDOM COMMENT On Jun 28, 2001 this sequence version replaced gi:4741401. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302465246| COMMENT VNTNAME|cDEP1_D1 (CAB41885)| COMMENT VNTAUTHORNAME|JNA| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..277 /organism="Gallus gallus" /db_xref="taxon:9031" /tissue_type="intestine" /clone_lib="lambda ZAP II" /dev_stage="2 day posthatch" /country="United Kingdom" /vntifkey="269" Protein 1..277 /product="supporting-cell antigen" /function="putative receptor protein tyrosine phosphatase" /vntifkey="270" ORIGIN 1 enfesyfkkq qadsncgfae eyeelksagv hqpkfaaeia enrgknrynn vlpydisrvk 61 lsnpscttdd yinanympgy sskkafiaaq gplpntiedf wrmiwekniy sivmltkcve 121 qartkceqyw pdkqsksygd iivtmvsevv lpewtirdfn venadtmesh tvrqfhftsw 181 pdhgvpettd llinfrhlvh eyssqnpids pilvhcsagv grtgtfiaid rliqqiemen 241 tvdvygvvyd lrmhrplmvq tedqyvflnq cvmdiir // LOCUS cGLEPP1_D1 277 aa 27-JUN-2003 DEFINITION protein tyrosine phosphatase CRYP-2 [Gallus gallus]. ACCESSION AAB17968 DBSOURCE locus GGU65891 accession U65891.1 SOURCE Gallus gallus (chicken). ORGANISM Gallus gallus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. REFERENCE 1 (residues 1 to 1267) AUTHORS Bodden,K. and Bixby,J.L. TITLE CRYP-2: a receptor-type tyrosine phosphatase selectively expressed by developing vertebrate neurons JOURNAL J. Neurobiol. 31 (3), 309-324 (1996) MEDLINE 97067376 REFERENCE 2 (residues 1 to 1267) AUTHORS Bodden,K. and Bixby,J.L. TITLE Direct Submission JOURNAL Submitted (01-AUG-1996) Pharmacology, University of Miami, 1600 NW 10 Ave, Miami, FL 33136, USA COMMENT Method: conceptual translation. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302465459| COMMENT VNTNAME|cGLEPP1_D1 (AAB17968)| COMMENT VNTAUTHORNAME|JNA| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..276 /organism="Gallus gallus" /db_xref="taxon:9031" /tissue_type="brain" /vntifkey="269" Protein 1..276 /product="protein tyrosine phosphatase CRYP-2" /vntifkey="270" ORIGIN 1 ddfdgyikdm akdsdykfsl qfeelkligl diphfaadlp mnrcknrytn ilpydfsrvr 61 lvsmneeegs dyinanyipg ynspqeyiat qgplpetrnd fwkmvlqqks qiivmltqcn 121 ekrrvkcdhy wpftedpiay gditvemlse eehtdwvyrn frisyadevq dvmhfnytaw 181 pdhgvptana aesilqfvqm vrqksvkskg pmiihcsagv grtgtfiald wllqhirdhe 241 fvdilglvsd mrsyrmsmvq teeqyifihq cvqlmwq // LOCUS cPTP1B_D1\ 279 aa 17-MAY-2003 DEFINITION Protein-tyrosine phosphatase, non-receptor type 1 (Protein-tyrosine phosphatase 1B) (PTP-1B) (CPTP1). ACCESSION O13016 DBSOURCE swissprot: locus PTN1_CHICK, accession O13016; class: standard. extra accessions:Q90704,created: Dec 15, 1998. sequence updated: Dec 15, 1998. annotation updated: Oct 16, 2001. xrefs: gi: 2058554, gi: 2058555, gi: 1209884, gi: 1209885 xrefs (non-sequence databases): HSSPP18031, InterProIPR000387, InterProIPR000242, PfamPF00102, PRINTSPR00700, SMARTSM00194, PROSITEPS00383, PROSITEPS50056, PROSITEPS50055 KEYWORDS Hydrolase. SOURCE Gallus gallus (chicken). ORGANISM Gallus gallus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. REFERENCE 1 (residues 1 to 434) AUTHORS Balsamo,J., Leung,T., Ernst,H., Zanin,M.K., Hoffman,S. and Lilien,J. TITLE Regulated binding of PTP1B-like phosphatase to N-cadherin: control of cadherin-mediated adhesion by dephosphorylation of beta-catenin JOURNAL J. Cell Biol. 134 (3), 801-813 (1996) MEDLINE 96326683 REMARK SEQUENCE FROM N.A. TISSUE=Retina REFERENCE 2 (residues 1 to 434) AUTHORS Kim,C.W., Jung,E.J. and Kang,Y.-S. TITLE Cloning and characterization of a chicken protein tyrosine phosphatase, CPTP1 JOURNAL Exp. Mol. Med. 28, 207-213 (1996) REMARK SEQUENCE OF 14-369 FROM N.A. TISSUE=Intestine COMMENT ------------------------------------------------------------------- This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. The original entry is available from http://www.expasy.ch/sprot and http://www.ebi.ac.uk/sprot ------------------------------------------------------------------. [CATALYTIC ACTIVITY] PROTEIN TYROSINE PHOSPHATE + H(2)O = PROTEIN TYROSINE + ORTHOPHOSPHATE. [SUBCELLULAR LOCATION] ASSOCIATED TO THE ENDOPLASMIC RETICULUM VIA ITS C-TERMINAL DOMAIN WITH ITS PHOSPHATASE DOMAIN ORIENTED TOWARDS THE CYTOPLASM (BY SIMILARITY). [SIMILARITY] BELONGS TO THE NON-RECEPTOR CLASS OF THE PROTEIN-TYROSINE PHOSPHATASE FAMILY. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302464650| COMMENT VNTNAME|cPTP1B_D1 (O13016)| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..279 /organism="Gallus gallus" /db_xref="taxon:9031" /vntifkey="269" Protein 1..279 /gene="PTPN1" /product="Protein-tyrosine phosphatase, non-receptor type 1" /EC_number="3.1.3.48" /vntifkey="270" Region 0..0 /gene="PTPN1" /region_name="Conflict" /vntifkey="240" /label=PTPN1 /note="A -> R (IN REF. 2)." Region 40..279 /gene="PTPN1" /region_name="Domain" /vntifkey="1000" /label=PTPN1 /note="PROTEIN-TYROSINE PHOSPHATASE." Region 62..63 /gene="PTPN1" /region_name="Conflict" /vntifkey="240" /label=PTPN1 /note="GD -> RC (IN REF. 2)." Site 0..0 /gene="PTPN1" /site_type="active" /vntifkey="220" /label=PTPN1 ORIGIN 1 meiekefhrl dqaaswaaiy qdirheasdf pckvakhprn knrnryrdvs pfdhsrikln 61 qgdndyinas likmeeaqrs yiltqgplpn tcghfwemvw eqksrgvvml nrvmekgsik 121 caqywprkee kemffedtnl kltlisedik syytvrqlel enlttqetre ilhfhyttwp 181 dfgvpespas flnflfkvre sgslnpeygp vvvhcsagig rsgtfclvdt clllmdkrkd 241 pssvdvkqvl lemrkyrmgl iqtadqlrfs ylaviegak // LOCUS cPTPalpha_ 280 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase. ACCESSION AAB04150 DBSOURCE locus CHKPTPA accession L22437.1 SOURCE Gallus gallus (chicken). ORGANISM Gallus gallus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. REFERENCE 1 (residues 1 to 807) AUTHORS Fang,K.S. TITLE Structural and functional characterization of two chicken tyrosine phosphatases JOURNAL Thesis (1993) COMMENT Method: conceptual translation. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302463254| COMMENT VNTNAME|cPTPalpha_D1 (AAB04150)| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..280 /organism="Gallus gallus" /sub_species="domesticus" /db_xref="taxon:9031" /tissue_type="brain" /dev_stage="E10" /vntifkey="269" Protein 1..280 /product="protein tyrosine phosphatase" /vntifkey="270" Region 1..280 /product="protein tyrosine phosphatase" /vntifkey="203" /label=Chain_1 ORIGIN 1 dkleeeinrr igddnklfre efnalpacpi qatceaaske enkeknryvn ilpydhsrvh 61 ltpvegvpds hyintsfins yqeknkfiaa qgpkeetvnd fwrmiweqnt ativmvtnlk 121 erkeckcaqy wpdqgcwtyg nirvsvedvt vlvdytvrkf ciqqvgdvtn kkpqrlvtqf 181 hftswpdfgv pftpigmlkf lkkvktcnpq yagaivvhcs agvgrtgtfi vidamldmmh 241 aerkvdvygf vsriraqrcq mvqtdmqyvf iyqallehyl // LOCUS cPTPgamma_ 291 aa 17-MAY-2003 DEFINITION Protein-tyrosine phosphatase gamma precursor (R-PTP-gamma). ACCESSION Q98936 DBSOURCE swissprot: locus PTPG_CHICK, accession Q98936; class: standard. created: Jul 15, 1999. sequence updated: Jul 15, 1999. annotation updated: Jun 15, 2002. xrefs: gi: 1617477, gi: 1617478 xrefs (non-sequence databases): HSSPP18052, InterProIPR001148, InterProIPR003961, InterProIPR000387, InterProIPR000242, PfamPF00041, PfamPF00102, PfamPF00194, PRINTSPR00700, ProDomPD000865, SMARTSM00060, SMARTSM00194, PROSITEPS00383, PROSITEPS50056, PROSITEPS50055 KEYWORDS Glycoprotein; Transmembrane; Hydrolase; Repeat; Signal. SOURCE Gallus gallus (chicken). ORGANISM Gallus gallus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. REFERENCE 1 (residues 1 to 1422) AUTHORS Qinghua,X., Xiaojun,G., Cong,S., Zong,S.M., Jong,Y.J., Chan,J. and Wang,L.-H. TITLE Direct Submission JOURNAL Submitted (~OCT-1995) REMARK SEQUENCE FROM N.A. TISSUE=Brain, and Kidney COMMENT ------------------------------------------------------------------- This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. The original entry is available from http://www.expasy.ch/sprot and http://www.ebi.ac.uk/sprot ------------------------------------------------------------------. [CATALYTIC ACTIVITY] Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. [SUBCELLULAR LOCATION] Type I membrane protein (Probable). [SIMILARITY] IN THE N-TERMINAL SECTION; BELONGS TO THE EUKARYOTIC-TYPE CARBONIC ANHYDRASE FAMILY. [SIMILARITY] CONTAINS 2 PROTEIN-TYROSINE PHOSPHATASE DOMAINS. [SIMILARITY] CONTAINS 1 FIBRONECTIN TYPE III-LIKE DOMAIN. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302464404| COMMENT VNTNAME|cPTPgamma_D1 (Q98936)| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..291 /organism="Gallus gallus" /db_xref="taxon:9031" /vntifkey="269" Protein 1..291 /gene="PTPRG" /product="Protein-tyrosine phosphatase gamma precursor" /EC_number="3.1.3.48" /vntifkey="270" Region 1..291 /gene="PTPRG" /region_name="Mature chain" /vntifkey="203" /label=PTPRG /note="PROTEIN-TYROSINE PHOSPHATASE GAMMA." Region 1..291 /gene="PTPRG" /region_name="Domain" /vntifkey="1004" /label=PTPRG /note="CYTOPLASMIC (POTENTIAL)." Region 39..291 /gene="PTPRG" /region_name="Domain" /vntifkey="1000" /label=PTPRG /note="PROTEIN-TYROSINE PHOSPHATASE 1." Site 230..230 /gene="PTPRG" /site_type="active" /vntifkey="220" /label=PTPRG /note="BY SIMILARITY." ORIGIN 1 kqfvkhisel ysnnqhgfse dfeevqrcta dmnitaehsn hpdnkhknry inilaydhsr 61 vklrplpgkd skhsdyinan yvsgynkaka yiatqgplks tfedfwrmiw aqhtgiivmi 121 tnlvekgrrk cdqywptens eeygniivtl kstnihacyt vrplhgqehk dekgserkpk 181 grqnertviq yhytqwpdmg vpeyalpvlt fvrrssaart phmgpvvvhc sagvgrtgty 241 ividsmlqqi kdkstvnvlg flkhirtqrn ylvqteeqyi fihdalleai l // LOCUS cPTPsigma_ 275 aa 17-MAY-2003 DEFINITION protein-tyrosine-phosphatase (EC 3.1.3.48) - chicken. ACCESSION I50212 DBSOURCE pir: locus I50212; summary: #length 1499 #molecular-weight 168570 #checksum 8393 ; genetic: #gene CRYPalpha1 ; superfamily: leukocyte antigen-related protein; fibronectin type III repeat homology; immunoglobulin homology; leukocyte common antigen cytosolic domain homology; protein-tyrosine-phosphatase homology ; PIR dates: 13-Sep-1996 #sequence_revision 13-Sep-1996 #text_change 21-Jan-2000 . KEYWORDS phosphoprotein; phosphoric monoester hydrolase; tyrosine-specific phosphatase. SOURCE Gallus gallus (chicken). ORGANISM Gallus gallus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. REFERENCE 1 (residues 1 to 1499) AUTHORS Stoker,A.W. TITLE Isoforms of a novel cell adhesion molecule-like protein tyrosine phosphatase are implicated in neural development JOURNAL Mech. Dev. 46 (3), 201-217 (1994) MEDLINE 95001563 COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302465303| COMMENT VNTNAME|cPTPsigma_D1 (I50212)| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..275 /organism="Gallus gallus" /db_xref="taxon:9031" /vntifkey="269" Protein 1..275 /product="protein-tyrosine-phosphatase" /EC_number="3.1.3.48" /vntifkey="270" Region 1..275 /region_name="domain" /vntifkey="1000" /label=LAC /note="leukocyte common antigen cytosolic domain homology #label LAC" Site 214..214 /site_type="active" /vntifkey="220" /label=Active_Site_1 /note="Cys (phosphocysteine intermediate)" Site 220..220 /site_type="binding" /vntifkey="1007" /label=Binding_1 /note="substrate phosphate (Arg)" ORIGIN 1 selaehtehl kandnlklsq eyesidpgqq ftwehsnlev nkpknryanv iaydhsrvil 61 lpiegivgsd yinanyidgy rkqnayiatq gplpetfgdf wrmvweqrsa tivmmtklee 121 ksrikcdqyw pgrgtdtygm iqvtlldtie latfcvrtfs lhkngssekr evrqfqftaw 181 pdhgvpeypt pflaflrrvk tcnppdagpi vvhcsagvgr tgcfividam lerikhektv 241 diyghvtlmr sqrnymvqte dqysfihdal leava // LOCUS cPTPzeta_D 286 aa 17-MAY-2003 DEFINITION phosphotyrosyl phosphatase. ACCESSION AAA49015 DBSOURCE locus CHKPHOPHOS accession L27625.1 SOURCE Gallus gallus (chicken). ORGANISM Gallus gallus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. REFERENCE 1 (residues 1 to 832) AUTHORS Rowley,R.B., Lee,J.M., Corbeil,H.B., Charbonneau,R., Jue,K., Dankort,D.L. and Branton,P.E. TITLE Isolation of chicken phosphotyrosyl phosphatase cDNA sequences and identification of a brain-specific species related to human PTP zeta JOURNAL Cell. Mol. Biol. Res. 39 (3), 209-219 (1993) MEDLINE 94122757 COMMENT Method: conceptual translation. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302464518| COMMENT VNTNAME|cPTPzeta_D1 (AAA49015)| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..286 /organism="Gallus gallus" /sub_species="domesticus" /db_xref="taxon:9031" /tissue_type="embryo" /dev_stage="10 day" /tissue_lib="Clontech CL1001b" /vntifkey="269" Protein 1..286 /product="phosphotyrosyl phosphatase" /vntifkey="270" ORIGIN 1 khfpkhvadl hasngfseef eeiqsctvdl gitsdssnhp dnknknryin ivaydhtrvk 61 laqlaekdgk ltdyinanyv dgynkpkayi aaqgplksta edfwrmiweh nvevivmitn 121 llekgrrkcd qywpaegsee ygnflvtqks vhvlayytvr nftlrntkik kgsqkgrssg 181 rvvtqyhytq wpdmgvpeyt lpvltfvrka shakrhavgp ivvhcsagvg rtgtyvvlds 241 mlqqiqhegt vnifgflkhi rtqrnylvqt eeqyifihda lveail // LOCUS cSHP2_D1\( 300 aa 17-MAY-2003 DEFINITION protein-tyrosine-phosphatase (EC 3.1.3.48), nonreceptor type 11 - chicken. ACCESSION JC5167 DBSOURCE pir: locus JC5167; summary: #length 593 #molecular-weight 67982 #checksum 3712 ; superfamily: protein-tyrosine-phosphatase, nonreceptor type 6; protein-tyrosine-phosphatase homology; SH2 homology ; PIR dates: 21-Feb-1997 #sequence_revision 27-Feb-1997 #text_change 16-Jul-1999 . KEYWORDS phosphoprotein; phosphoric monoester hydrolase; tyrosine-specific phosphatase. SOURCE Gallus gallus (chicken). ORGANISM Gallus gallus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. REFERENCE 1 (residues 1 to 593) AUTHORS Park,C.Y., LaMontagne,K.R., Tonks,N.K. and Hayman,M.J. TITLE Cloning and expression of the chicken protein tyrosine phosphatase SH-PTP2 JOURNAL Gene 177 (1-2), 93-97 (1996) MEDLINE 97080506 REMARK erythroblast COMMENT This enzyme plays positive roles in mitogenic signaling and early development. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302464602| COMMENT VNTNAME|cSHP2_D1 (JC5167)| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..300 /organism="Gallus gallus" /db_xref="taxon:9031" /vntifkey="269" Protein 1..300 /product="protein-tyrosine-phosphatase, nonreceptor type 11" /EC_number="3.1.3.48" /vntifkey="270" /note="phosphotyrosine phosphatase; PTP1D; PTP2c; SH-PTP2; SyP" Region 50..287 /region_name="domain" /vntifkey="1000" /label=PTP /note="protein-tyrosine-phosphatase homology #label PTP" Site 236..236 /site_type="active" /vntifkey="220" /label=Active_Site_1 /note="Cys (phosphocysteine intermediate)" Site 242..242 /site_type="binding" /vntifkey="1007" /label=Binding_1 /note="substrate phosphate (Arg)" ORIGIN 1 aeiesrvrel sklaettdkv kqgfweefet lqqqecklly srkegqrqen knknryknil 61 pfdhtrvvlh dgdpnepvsd yinaniimpe fetkcnnskp kksyiatqgc lqntvndfwr 121 mvfqensrvi vmttkeverg kskcvkywpd eyslkeygvm rvrnvkesaa hdytlrelkl 181 skvgqgnter tvwqyhfrtw pdhgvpsdpg gvldfleevh hkqesisdag pvvvhcsagi 241 grtgtfivid ilidiirekg vdcdidvpkt iqmvrsqrsg mvqteaqyrf iymavqhyie // LOCUS cypcaCD45_ 276 aa 17-MAY-2003 DEFINITION CD45 [Cyprinus carpio]. ACCESSION BAA92179 DBSOURCE accession AB031424.1 SOURCE Cyprinus carpio (common carp). ORGANISM Cyprinus carpio Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Cyprinus. REFERENCE 1 AUTHORS Fujiki,K., Shin,D.H., Nakao,M. and Yano,T. TITLE Molecular cloning of carp (Cyprinus carpio) leucocyte cell-derived chemotaxin 2, glia maturation factor beta, CD45 and lysozyme C by use of suppression subtractive hybridisation JOURNAL Fish Shellfish Immunol. 10 (7), 643-650 (2000) MEDLINE 20531692 REFERENCE 2 (residues 1 to 1216) AUTHORS Fujiki,K., Nakao,M., Shin,D. and Yano,T. TITLE Direct Submission JOURNAL Submitted (24-AUG-1999) Kazuhiro Fujiki, Kyushu University, Laboratory of Marine Biochemistry, Faculty of Agriculture; Hakozaki 6-10-1, Higashi-ku, Fukuoka, Fukuoka 812-8581, Japan (E-mail:fujikik@agr.kyushu-u.ac.jp, Tel:81-92-642-2896, Fax:81-92-642-2894) COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302454614| COMMENT VNTNAME|cypcaCD45_D1 (BAA92179)| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..276 /organism="Cyprinus carpio" /db_xref="taxon:7962" /cell_type="leukocytes" /vntifkey="269" Protein 1..276 /product="CD45" /vntifkey="270" ORIGIN 1 gglveayknk iadegrlfmd efqsiprifs nytikeakks enqyknryvd ilpydynrvt 61 lstggednyi nasfiegyre pkkyiaaqgp kdetvvdfwr mvweqkssii vmvtrceegn 121 ktkcaqywps ldreaeifee fvvkirseeh cpdyvirhli lnnkrekgse revthiqfis 181 wpdhgvpgdp slllklrrrv nsfknffsgp vvvhcsagvg rtgtymsida miesleaegr 241 vdiygfvakl rrqrclmvqv eaqyilihta lieynq // LOCUS fuCD45_D1\ 279 aa 17-MAY-2003 DEFINITION CD45 [Takifugu rubripes]. ACCESSION CAB96211 DBSOURCE embl locus FRU243429, accession AJ243429.1 SOURCE Takifugu rubripes. ORGANISM Takifugu rubripes Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; Acanthomorpha; Acanthopterygii; Percomorpha; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu. REFERENCE 1 AUTHORS Diaz del Pozo,E.M., Beverley,P.C. and Timon,M. TITLE Genomic structure and sequence of the leukocyte common antigen (CD45) from the pufferfish Fugu rubripes and comparison with its mammalian homologue JOURNAL Unpublished REFERENCE 2 (residues 1 to 1246) AUTHORS Diaz del Pozo,E.M. TITLE Direct Submission JOURNAL Submitted (25-JUN-1999) Diaz del Pozo E.M., CD45 Group, The Edward Jenner Institute for Vaccine Research, High Street, Compton, Newbury, Berkshire, RG20 7NN, UNITED KINGDOM COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302488418| COMMENT VNTNAME|fuCD45_D1 (CAB96211)| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..279 /organism="Takifugu rubripes" /db_xref="taxon:31033" /clone="ptp-16" /tissue_type="spleen" /vntifkey="269" Protein 1..279 /product="CD45" /EC_number="3.1.3.48" /function="protein tyrosine phosphatase" /vntifkey="270" Region 1..279 /product="CD45" /EC_number="3.1.3.48" /vntifkey="203" /label=Chain_1 ORIGIN 1 etlldaykrk iadegrlfla efqsiprifs kytvkeakks hnvpknryvd ilpydynrvq 61 lttgngsagc dyinasfidg fkelkkyiaa qgpkeetvsn fwrmiweqqt siivmvsrce 121 egnrikcaqy wpsedrdtei feefivklts edhypdyiir hlsltnkkdk gserevthiq 181 fmswpdhgvp eeaqlllklr rrvnsfknff sgpivvhcsa gvgrtgtyig idammeslea 241 egrvdiygyv vmlrrqrclm vqveaqyili hqallehtq // LOCUS hBDP1_D1\( 288 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 18; brain-derived phosphatase [Homo sapiens]. ACCESSION NP_055184 DBSOURCE REFSEQ: accession NM_014369.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 460) AUTHORS Kim,Y.W., Wang,H., Sures,I., Lammers,R., Martell,K.J. and Ullrich,A. TITLE Characterization of the PEST family protein tyrosine phosphatase BDP1 JOURNAL Oncogene 13 (10), 2275-2279 (1996) MEDLINE 97108674 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X79568.1 and BI261717.1. On Jan 25, 2002 this sequence version replaced gi:7657484. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This gene was found to be expressed in brain, colon tissues, and several different tumor-derived cell lines. The bilogical function of this PTP has not yet been determined. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hBDP1_D1 (NP_055184) PTPN18| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..288 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="2" /map="2q21.2" /vntifkey="269" Protein 1..288 /product="protein tyrosine phosphatase, non-receptor type 18" /EC_number="3.1.3.48" /vntifkey="270" /note="brain-derived phosphatase" Region 21..287 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 dsarsflerl earggregav lagefsdiqa csaawkadgv cstvagsrpe nvrknrykdv 61 lpydqtrvil sllqeeghsd yingnfirgv dgslayiatq gplphtlldf wrlvwefgvk 121 vilmacreie ngrkrceryw aqeqeplqtg lfcitlikek wlnedimlrt lkvtfqkesr 181 svyqlqymsw pdrgvpsspd hmlamveear rlqgsgpepl cvhcsagcgr tgvlctvdyv 241 rqllltqmip pdfslfdvvl kmrkqrpaav qteeqyrfly htvaqmfc // LOCUS hCD45_D1\( 279 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, C isoform 1 precursor; protein tyrosine phosphatase, receptor type, c polypeptide; leukocyte-common antigen; T200 glycoprotein; human homolog of severe combined immunodeficiency due to PTPRC deficiency; SCID due to PTPRC deficiency; CD45 antigen [Homo sapiens]. ACCESSION NP_002829 DBSOURCE REFSEQ: accession NM_002838.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 1304) AUTHORS Baldwin,T.A. and Ostergaard,H.L. TITLE The protein-tyrosine phosphatase CD45 reaches the cell surface via golgi-dependent and -independent pathways JOURNAL J. Biol. Chem. 277 (52), 50333-50340 (2002) MEDLINE 22384317 REMARK GeneRIF: reaches the cell surface via Golgi-dependent and -independent pathways REFERENCE 2 (residues 1 to 1304) AUTHORS Harashima,A., Suzuki,M., Okochi,A., Yamamoto,M., Matsuo,Y., Motoda,R., Yoshioka,T. and Orita,K. TITLE CD45 tyrosine phosphatase inhibits erythroid differentiation of umbilical cord blood CD34+ cells associated with selective inactivation of Lyn JOURNAL Blood 100 (13), 4440-4445 (2002) MEDLINE 22340750 REMARK GeneRIF: CD45 may play a pivotal role in erythropoiesis. CD45 tyrosine phosphatase inhibits erythroid differentiation of umbilical cord blood CD34+ cells associated with selective inactivation of Lyn. REFERENCE 3 (residues 1 to 1304) AUTHORS Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J. TITLE Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases JOURNAL J. Biol. Chem. 277 (49), 47263-47269 (2002) MEDLINE 22344739 REMARK GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are a common but specific mechanism that is likely to be regulated- domain2s and the wedge structures are crucial determinants of binding specificity, thus regulating cross-talk between RPTPs REFERENCE 4 (residues 1 to 1304) AUTHORS Pradhan,D. and Morrow,J. TITLE The spectrin-ankyrin skeleton controls CD45 surface display and interleukin-2 production JOURNAL Immunity 17 (3), 303-315 (2002) MEDLINE 22241694 REMARK GeneRIF: The spectrin-ankyrin skeleton controls CD45 surface display and interleukin-2 production. REFERENCE 5 (residues 1 to 1304) AUTHORS Ballerini,C., Rosati,E., Salvetti,M., Ristori,G., Cannoni,S., Biagioli,T., Massacesi,L., Sorbi,S. and Vergelli,M. TITLE Protein tyrosine phosphatase receptor-type C exon 4 gene mutation distribution in an Italian multiple sclerosis population JOURNAL Neurosci. Lett. 328 (3), 325-327 (2002) MEDLINE 22142931 REMARK GeneRIF: Role of the C-->G mutation in position 77 of exon 4 of the protein tyrosine phosphatase receptor-type C (PTPRC) gene, coding for the CD45 molecule, for the development of multiple sclerosis (MS) in Italy. REFERENCE 6 (residues 1 to 1304) AUTHORS Yamada,T., Zhu,D., Saxon,A. and Zhang,K. TITLE CD45 controls interleukin-4-mediated IgE class switch recombination in human B cells through its function as a Janus kinase phosphatase JOURNAL J. Biol. Chem. 277 (32), 28830-28835 (2002) MEDLINE 22151051 REMARK GeneRIF: CD45 controls interleukin-4-mediated IgE class switch recombination in human B cells REFERENCE 7 (residues 1 to 1304) AUTHORS Yu,C., Yu,H.S., Sun,K.H., Hsieh,S.C. and Tsai,C.Y. TITLE Anti-CD45 isoform antibodies enhance phagocytosis and gene expression of IL-8 and TNF-alpha in human neutrophils by differential suppression on protein tyrosine phosphorylation and p56lck tyrosine kinase JOURNAL Clin. Exp. Immunol. 129 (1), 78-85 (2002) MEDLINE 22095000 REMARK GeneRIF: Biological functions of membrane expressed CD45 isoforms on PMNs were studied. Cross-linking of CD45 isoforms by specific MAbs stimulated different PMN activities by differential suppression on protein tyrosine phosphorylation and p56lck. REFERENCE 8 (residues 1 to 1304) AUTHORS Jacobsen,M., Hoffmann,S., Cepok,S., Stei,S., Ziegler,A., Sommer,N. and Hemmer,B. TITLE A novel mutation in PTPRC interferes with splicing and alters the structure of the human CD45 molecule JOURNAL Immunogenetics 54 (3), 158-163 (2002) MEDLINE 22067726 REMARK GeneRIF: a mutation in PTPRC interferes with splicing and alters the structure of the CD45 molecule REFERENCE 9 (residues 1 to 1304) AUTHORS Tchilian,E.Z. and Beverley,P.C. TITLE CD45 in memory and disease JOURNAL Arch. Immunol. Ther. Exp. (Warsz.) 50 (2), 85-93 (2002) MEDLINE 22017393 REMARK GeneRIF: Role of high and low molecular weight isoforms of CD45 in the function of na##ve and memory T lymphocytes. Review. REFERENCE 10 (residues 1 to 1304) AUTHORS Fajka-Boja,R., Szemes,M., Ion,G., Legradi,A., Caron,M. and Monostori,E. TITLE Receptor tyrosine phosphatase, CD45 binds galectin-1 but does not mediate its apoptotic signal in T cell lines JOURNAL Immunol. Lett. 82 (1-2), 149-154 (2002) MEDLINE 22003829 REMARK GeneRIF: Receptor tyrosine phosphatase, CD45 binds galectin-1 but does not mediate its apoptotic signal in Jurkat cells REFERENCE 11 (residues 1 to 1304) AUTHORS Fukuhara,K., Okumura,M., Shiono,H., Inoue,M., Kadota,Y., Miyoshi,S. and Matsuda,H. TITLE A study on CD45 isoform expression during T-cell development and selection events in the human thymus JOURNAL Hum. Immunol. 63 (5), 394-404 (2002) MEDLINE 21972715 REMARK GeneRIF: analysis of CD45 isoform expression during T-cell development and selection in the human thymus REFERENCE 12 (residues 1 to 1304) AUTHORS Wu,L., Fu,J. and Shen,S.H. TITLE SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription JOURNAL Mol. Cell. Biol. 22 (8), 2673-2686 (2002) MEDLINE 21907230 REMARK GeneRIF: SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription. REFERENCE 13 (residues 1 to 1304) AUTHORS Ishikawa,H., Tsuyama,N., Abroun,S., Liu,S., Li,F.J., Taniguchi,O. and Kawano,M.M. TITLE Requirements of src family kinase activity associated with CD45 for myeloma cell proliferation by interleukin-6 JOURNAL Blood 99 (6), 2172-2178 (2002) MEDLINE 21866149 REMARK GeneRIF: Requirements of src family kinase activity associated with CD45 for myeloma cell proliferation by interleukin-6 REFERENCE 14 (residues 1 to 1304) AUTHORS Tchilian,E.Z., Dawes,R., Ramaley,P.A., Whitworth,J.A., Yuldasheva,N., Wells,R.S., Watera,C., French,N., Gilks,C.F., Kunachiwa,W., Ruzibakiev,R., Leetrakool,N., Carrington,C.V., Ramdath,D.D., Gotch,F., Stephens,H.A., Hill,A.V. and Beverley,P.C. TITLE A CD45 polymorphism associated with abnormal splicing is absent in African populations JOURNAL Immunogenetics 53 (10-11), 980-983 (2002) MEDLINE 21850514 REMARK GeneRIF: we examined the frequency of the C77G allele in African and Asian populations from countries with high or low prevalence of HIV infection; Here we report that the variant CD45 C77G allele is absent in African populations REFERENCE 15 (residues 1 to 1304) AUTHORS Wood,J.P., Bieda,K., Segni,M., Herwig,J., Krause,M., Usadel,K.H. and Badenhoop,K. TITLE CD45 exon 4 point mutation does not confer susceptibility to type 1 diabetes mellitus or Graves' disease JOURNAL Eur. J. Immunogenet. 29 (1), 73-74 (2002) MEDLINE 21830605 REMARK GeneRIF: CD45 variant (C77G, exon 4) does not confer susceptibility to either IDDM or Graves' disease REFERENCE 16 (residues 1 to 1304) AUTHORS Moro,H., Iwai,K., Mori,N., Watanabe,M., Fukushi,M., Oie,M., Arai,M., Tanaka,Y., Miyawaki,T., Gejyo,F., Arakawa,M. and Fujii,M. TITLE Interleukin-2-dependent but not independent T-cell lines infected with human T-cell leukemia virus type 1 selectively express CD45RO, a marker for persistent infection in vivo JOURNAL Virus Genes 23 (3), 263-271 (2001) MEDLINE 21636965 REMARK GeneRIF: role of CD45RO in the persistent HTLV-1 infection in vivo REFERENCE 17 (residues 1 to 1304) AUTHORS Irie-Sasaki,J., Sasaki,T., Matsumoto,W., Opavsky,A., Cheng,M., Welstead,G., Griffiths,E., Krawczyk,C., Richardson,C.D., Aitken,K., Iscove,N., Koretzky,G., Johnson,P., Liu,P., Rothstein,D.M. and Penninger,J.M. TITLE CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling JOURNAL Nature 409 (6818), 349-354 (2001) MEDLINE 21069057 REFERENCE 18 (residues 1 to 1304) AUTHORS Goff,L.K., van Soest,S., Timon,M., Tchilian,E. and Beverley,P.C. TITLE Protein tyrosine phosphatase receptor type C polypeptide (PTPRC) on human chromosome band 1q31-->q32 localizes with marker D1S413(1) on a 610-kb yeast artificial chromosome JOURNAL Cytogenet. Cell Genet. 87 (3-4), 223-224 (1999) MEDLINE 20169194 REFERENCE 19 (residues 1 to 1304) AUTHORS Petricoin,E.F. III, Ito,S., Williams,B.L., Audet,S., Stancato,L.F., Gamero,A., Clouse,K., Grimley,P., Weiss,A., Beeler,J., Finbloom,D.S., Shores,E.W., Abraham,R. and Larner,A.C. TITLE Antiproliferative action of interferon-alpha requires components of T-cell-receptor signalling JOURNAL Nature 390 (6660), 629-632 (1997) MEDLINE 98065953 REFERENCE 20 (residues 1 to 1304) AUTHORS Kaplan,R., Morse,B., Huebner,K., Croce,C., Howk,R., Ravera,M., Ricca,G., Jaye,M. and Schlessinger,J. TITLE Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (18), 7000-7004 (1990) MEDLINE 90384936 REFERENCE 21 (residues 1 to 1304) AUTHORS Schraven,B., Samstag,Y., Altevogt,P. and Meuer,S.C. TITLE Association of CD2 and CD45 on human T lymphocytes JOURNAL Nature 345 (6270), 71-74 (1990) MEDLINE 90231464 REFERENCE 22 (residues 1 to 1304) AUTHORS Pingel,J.T. and Thomas,M.L. TITLE Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation JOURNAL Cell 58 (6), 1055-1065 (1989) MEDLINE 89376557 REFERENCE 23 (residues 1 to 1304) AUTHORS Charbonneau,H., Tonks,N.K., Walsh,K.A. and Fischer,E.H. TITLE The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase JOURNAL Proc. Natl. Acad. Sci. U.S.A. 85 (19), 7182-7186 (1988) MEDLINE 89017162 REFERENCE 24 (residues 1 to 1304) AUTHORS Streuli,M., Hall,L.R., Saga,Y., Schlossman,S.F. and Saito,H. TITLE Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigens JOURNAL J. Exp. Med. 166 (5), 1548-1566 (1987) MEDLINE 88061067 REFERENCE 25 (residues 1 to 1304) AUTHORS Ralph,S.J., Thomas,M.L., Morton,C.C. and Trowbridge,I.S. TITLE Structural variants of human T200 glycoprotein (leukocyte-common antigen) JOURNAL EMBO J. 6 (5), 1251-1257 (1987) MEDLINE 87275816 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Y00638.1 and Y00062.1. On Feb 8, 2002 this sequence version replaced gi:4506307. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. Transcript Variant: This variant (1) encodes the longest isoform (1). COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hCD45_D1 (NP_002829) PTPRC| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..279 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="1" /map="1q31-q32" /vntifkey="269" Protein 1..279 /product="protein tyrosine phosphatase, receptor type, C isoform 1 precursor" /EC_number="3.1.3.48" /vntifkey="270" /note="protein tyrosine phosphatase, receptor type, c polypeptide; leukocyte-common antigen; T200 glycoprotein; human homolog of severe combined immunodeficiency due to PTPRC deficiency; SCID due to PTPRC deficiency; CD45 antigen" Region 1..279 /product="protein tyrosine phosphatase, receptor type, C" /vntifkey="203" /label=Chain_1 Region 17..277 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_2 /note="PTPc" ORIGIN 1 dilletykrk iadegrlfla efqsiprvfs kfpikearkp fnqnknryvd ilpydynrve 61 lseingdags nyinasyidg fkeprkyiaa qgprdetvdd fwrmiweqka tvivmvtrce 121 egnrnkcaey wpsmeegtra fgdvvvkinq hkrcpdyiiq klnivnkkek atgrevthiq 181 ftswpdhgvp edphlllklr rrvnafsnff sgpivvhcsa gvgrtgtyig idamleglea 241 enkvdvygyv vklrrqrclm vqveaqyili hqalveynq // LOCUS hDEP1_D1\( 277 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, J precursor; protein tyrosine phosphatase, receptor type, J polypeptide; human density enhanced phosphatase-1; CD148 antigen [Homo sapiens]. ACCESSION NP_002834 DBSOURCE REFSEQ: accession NM_002843.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 1337) AUTHORS Ruivenkamp,C.A., van Wezel,T., Zanon,C., Stassen,A.P., Vlcek,C., Csikos,T., Klous,A.M., Tripodis,N., Perrakis,A., Boerrigter,L., Groot,P.C., Lindeman,J., Mooi,W.J., Meijjer,G.A., Scholten,G., Dauwerse,H., Paces,V., van Zandwijk,N., van Ommen,G.J. and Demant,P. TITLE Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers JOURNAL Nat. Genet. 31 (3), 295-300 (2002) MEDLINE 22084388 REMARK GeneRIF: This protein is frequently deleted in human breast cancers. REFERENCE 2 (residues 1 to 1337) AUTHORS Baker,J.E., Majeti,R., Tangye,S.G. and Weiss,A. TITLE Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation JOURNAL Mol. Cell. Biol. 21 (7), 2393-2403 (2001) MEDLINE 21160271 REFERENCE 3 (residues 1 to 1337) AUTHORS Kovalenko,M., Denner,K., Sandstrom,J., Persson,C., Gross,S., Jandt,E., Vilella,R., Bohmer,F. and Ostman,A. TITLE Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1 JOURNAL J. Biol. Chem. 275 (21), 16219-16226 (2000) MEDLINE 20283660 REFERENCE 4 (residues 1 to 1337) AUTHORS Gross,S., Knebel,A., Tenev,T., Neininger,A., Gaestel,M., Herrlich,P. and Bohmer,F.D. TITLE Inactivation of protein-tyrosine phosphatases as mechanism of UV-induced signal transduction JOURNAL J. Biol. Chem. 274 (37), 26378-26386 (1999) MEDLINE 99403084 REFERENCE 5 (residues 1 to 1337) AUTHORS Tangye,S.G., Phillips,J.H., Lanier,L.L., de Vries,J.E. and Aversa,G. TITLE CD148: a receptor-type protein tyrosine phosphatase involved in the regulation of human T cell activation JOURNAL J. Immunol. 161 (7), 3249-3255 (1998) MEDLINE 98430639 REFERENCE 6 (residues 1 to 1337) AUTHORS de la Fuente-Garcia,M.A., Nicolas,J.M., Freed,J.H., Palou,E., Thomas,A.P., Vilella,R., Vives,J. and Gaya,A. TITLE CD148 is a membrane protein tyrosine phosphatase present in all hematopoietic lineages and is involved in signal transduction on lymphocytes JOURNAL Blood 91 (8), 2800-2809 (1998) MEDLINE 98200586 REFERENCE 7 (residues 1 to 1337) AUTHORS Honda,H., Inazawa,J., Nishida,J., Yazaki,Y. and Hirai,H. TITLE Molecular cloning, characterization, and chromosomal localization of a novel protein-tyrosine phosphatase, HPTP eta JOURNAL Blood 84 (12), 4186-4194 (1994) MEDLINE 95086212 REFERENCE 8 (residues 1 to 1337) AUTHORS Ostman,A., Yang,Q. and Tonks,N.K. TITLE Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density JOURNAL Proc. Natl. Acad. Sci. U.S.A. 91 (21), 9680-9684 (1994) MEDLINE 95024024 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U10886.1. On Feb 22, 2002 this sequence version replaced gi:4506315. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This PTP is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 (PLCG1) and Linker for Activation of T Cells (LAT). This PTP was also found to dephosphorylate PDGF beta receptor, and may be involved in UV-induced signal transduction. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hDEP1_D1 (NP_002834) PTPRJ| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..277 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="11" /map="11p11.2" /vntifkey="269" Protein 1..277 /product="protein tyrosine phosphatase, receptor type, J precursor" /EC_number="3.1.3.48" /vntifkey="270" /note="protein tyrosine phosphatase, receptor type, J polypeptide; human density enhanced phosphatase-1; CD148 antigen" Region 1..277 /product="protein tyrosine phosphatase, receptor type, J" /vntifkey="203" /label=Chain_1 Region 17..277 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 enfeayfkkq qadsncgfae eyedlklvgi sqpkyaaela enrgknrynn vlpydisrvk 61 lsvqthstdd yinanympgy hskkdfiatq gplpntlkdf wrmvweknvy aiimltkcve 121 qgrtkceeyw pskqaqdygd itvamtseiv lpewtirdft vkniqtsesh plrqfhftsw 181 pdhgvpdttd llinfrylvr dymkqsppes pilvhcsagv grtgtfiaid rliyqienen 241 tvdvygivyd lrmhrplmvq tedqyvflnq cvldivr // LOCUS hGLEPP1_D1 277 aa 27-JUN-2003 DEFINITION receptor-type protein tyrosine phosphatase O isoform a precursor; glomerular epithelial protein-1; protein tyrosine phosphatase PTP-U2; phosphotyrosine phosphatase U2; PTPase U2; PTPROt [Homo sapiens]. ACCESSION NP_109592 DBSOURCE REFSEQ: accession NM_030667.1 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 1216) AUTHORS Aguiar,R.C., Yakushijin,Y., Kharbanda,S., Tiwari,S., Freeman,G.J. and Shipp,M.A. TITLE PTPROt: an alternatively spliced and developmentally regulated B-lymphoid phosphatase that promotes G0/G1 arrest JOURNAL Blood 94 (7), 2403-2413 (1999) MEDLINE 99428326 REFERENCE 2 (residues 1 to 1216) AUTHORS Seimiya,H., Sawabe,T., Inazawa,J. and Tsuruo,T. TITLE Cloning, expression and chromosomal localization of a novel gene for protein tyrosine phosphatase (PTP-U2) induced by various differentiation-inducing agents JOURNAL Oncogene 10 (9), 1731-1738 (1995) MEDLINE 95273089 REFERENCE 3 (residues 1 to 1216) AUTHORS Wiggins,R.C., Wiggins,J.E., Goyal,M., Wharram,B.L. and Thomas,P.E. TITLE Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13 JOURNAL Genomics 27 (1), 174-181 (1995) MEDLINE 95394455 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z48541.1 and U20489.1. Summary: This gene encodes a receptor-type protein tyrosine phosphatase containing a single intracellular catalytic domain with a characteristic signature motif. The gene product, which has a transmembrane domain, is an integral membrane protein. Several alternatively spliced transcript variants, some of which encode different isoforms of the protein, have been described. These variants exhibit tissue-specific expression. Transcript Variant: This variant (1) encodes the longest isoform (a) known to date. The encoded protein has a large extracellular domain containing 8 repeats of a fibronectin type III-like motif. This variant is expressed in the glomerulus of kidney and in brain. In kidney, it may play a role in regulating glomerular epithelial cell (podocyte) structure and/or function. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hGLEPP1_D1 (NP_109592) PTPRO| COMMENT VNTAUTHORNAME|JNA| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers Region 17..272 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_2 /note="PTPc" Region 214..224 /region_name="catalytic domain signature motif" /vntifkey="1000" /label=Dom_Misc_3 ORIGIN 1 ddfdayikdm akdsdykfsl qfeelkligl diphfaadlp lnrcknrytn ilpydfsrvr 61 lvsmneeega dyinanyipg ynspqeyiat qgplpetrnd fwkmvlqqks qiivmltqcn 121 ekrrvkcdhy wpfteepiay gditvemise eeqddwacrh frinyademq dvmhfnytaw 181 pdhgvptana aesilqfvhm vrqqatkskg pmiihcsagv grtgtfiald rllqhirdhe 241 fvdilglvse mrsyrmsmvq teeqyifihq cvqlmwm // LOCUS hHDPTP_D1\ 286 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 23; His-domain protein tyrosine phosphatase [Homo sapiens]. ACCESSION NP_056281 DBSOURCE REFSEQ: accession NM_015466.1 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 1636) AUTHORS Qu,X., Zhai,Y., Wei,H., Zhang,C., Xing,G., Lu,C., Wang,M. and He,F. TITLE Cloning, chromosomal assignment and tissue expression of a novel human protein tyrosine phosphatase (PTP-TD14) gene JOURNAL I Chuan 23 (6), 1-9 (2001) REFERENCE 2 (residues 1 to 1636) AUTHORS Toyooka,S., Ouchida,M., Jitsumori,Y., Tsukuda,K., Sakai,A., Nakamura,A., Shimizu,N. and Shimizu,K. TITLE HD-PTP: A novel protein tyrosine phosphatase gene on human chromosome 3p21.3 JOURNAL Biochem. Biophys. Res. Commun. 278 (3), 671-678 (2000) MEDLINE 20549011 COMMENT PREDICTED REFSEQ: The mRNA record is supported by experimental evidence; however, the coding sequence is predicted. The reference sequence was derived from AF290614.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hHDPTP_D1 (NP_056281) PTPN23| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..286 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="3" /map="3p21.3" /clone="F2896" /tissue_type="liver" /dev_stage="fetus" /vntifkey="269" Protein 1..286 /product="protein tyrosine phosphatase, non-receptor type 23" /vntifkey="270" /note="His-domain protein tyrosine phosphatase" Region 23..286 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_2 /note="PTPc" ORIGIN 1 erlrqlqqel eafrgqlgdv galdtvwrel qdaqehdarg rsiaiarcys lknrhqdvmp 61 ydsnrvvlrs gkddyinasc veglspycpp lvatqaplpg taadfwlmvh eqkvsvivml 121 vseaemekqk varyfpterg qpmvhgalsl alssvrstet hvervlslqf rdqslkrslv 181 hlhfptwpel glpdspsnll rfiqevhahy lhqrplhtpi ivhcssgvgr tgafallyaa 241 vqeveagngi pelpqlvrrm rqqrkhmlqe klhlrfcyea vvrhve // LOCUS hHePTP_D1\ 273 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 7 isoform 1; protein-tyrosine phoshatase, nonreceptor-type, stress induced; hematopoietic protein-tyrosine phosphatase [Homo sapiens]. ACCESSION NP_002823 DBSOURCE REFSEQ: accession NM_002832.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 360) AUTHORS Oh-hora,M., Ogata,M., Mori,Y., Adachi,M., Imai,K., Kosugi,A. and Hamaoka,T. TITLE Direct suppression of TCR-mediated activation of extracellular signal-regulated kinase by leukocyte protein tyrosine phosphatase, a tyrosine-specific phosphatase JOURNAL J. Immunol. 163 (3), 1282-1288 (1999) MEDLINE 99343735 REFERENCE 2 (residues 1 to 360) AUTHORS Saxena,M., Williams,S., Brockdorff,J., Gilman,J. and Mustelin,T. TITLE Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP) JOURNAL J. Biol. Chem. 274 (17), 11693-11700 (1999) MEDLINE 99223488 REFERENCE 3 (residues 1 to 360) AUTHORS Saxena,M., Williams,S., Gilman,J. and Mustelin,T. TITLE Negative regulation of T cell antigen receptor signal transduction by hematopoietic tyrosine phosphatase (HePTP) JOURNAL J. Biol. Chem. 273 (25), 15340-15344 (1998) MEDLINE 98288260 REFERENCE 4 (residues 1 to 360) AUTHORS Swieter,M., Berenstein,E.H., Swaim,W.D. and Siraganian,R.P. TITLE Aggregation of IgE receptors in rat basophilic leukemia 2H3 cells induces tyrosine phosphorylation of the cytosolic protein-tyrosine phosphatase HePTP JOURNAL J. Biol. Chem. 270 (37), 21902-21906 (1995) MEDLINE 95394959 REFERENCE 5 (residues 1 to 360) AUTHORS Adachi,M., Sekiya,M., Isobe,M., Kumura,Y., Ogita,Z., Hinoda,Y., Imai,K. and Yachi,A. TITLE Molecular cloning and chromosomal mapping of a human protein-tyrosine phosphatase LC-PTP JOURNAL Biochem. Biophys. Res. Commun. 186 (3), 1607-1615 (1992) MEDLINE 92378634 REFERENCE 6 (residues 1 to 360) AUTHORS Adachi,M., Sekiya,M., Arimura,Y., Takekawa,M., Itoh,F., Hinoda,Y., Imai,K. and Yachi,A. TITLE Protein-tyrosine phosphatase expression in pre-B cell NALM-6 JOURNAL Cancer Res. 52 (3), 737-740 (1992) MEDLINE 92119637 REFERENCE 7 (sites) AUTHORS Zanke,B., Suzuki,H., Kishihara,K., Mizzen,L., Minden,M., Pawson,A. and Mak,T.W. TITLE Cloning and expression of an inducible lymphoid-specific, protein tyrosine phosphatase (HePTPase) JOURNAL Eur. J. Immunol. 22 (1), 235-239 (1992) MEDLINE 92111631 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC001746.1, BG340453.1, D11327.1 and M64322.1. On Jan 25, 2002 this sequence version replaced gi:4506299. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Three alternatively spliced transcript variants of this gene, which encode two distinct isoforms, are reported. Transcript Variant: This variant (1) contains a different 5' region, which includes a part of the coding sequence when compared to variant 2. It thus encodes a protein that has a shorter N-terminus, as compared to isoform 2. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hHePTP_D1 (NP_002823) PTPN7| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..273 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="1" /map="1q32.1" /vntifkey="269" Protein 1..273 /product="protein tyrosine phosphatase, non-receptor type 7 isoform 1" /vntifkey="270" /note="protein-tyrosine phoshatase, nonreceptor-type, stress induced; hematopoietic protein-tyrosine phosphatase" Region 17..271 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 hpltrwalqr qppspkqlee eflkipsnfv spedldipgh askdryktil pnpqsrvclg 61 raqsqedgdy inanyirgyd gkekvyiatq gpmpntvsdf wemvwqeevs livmltqlre 121 gkekcvhywp teeetygpfq iriqdmkecp eytvrqltiq yqeerrsvkh ilfsawpdhq 181 tpesagpllr lvaeveespe taahpgpivv hcsagigrtg cfiatrigcq qlkargevdi 241 lgivcqlrld rggmiqtaeq yqflhhtlal yag // LOCUS hIA2_D1\(N 279 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, N precursor; islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N precursor [Homo sapiens]. ACCESSION NP_002837 DBSOURCE REFSEQ: accession NM_002846.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 979) AUTHORS Sanjeevi,C.B., Das,A.K. and Shtauvere-Brameus,A. TITLE BCG vaccination and GAD65 and IA-2 autoantibodies in autoimmune diabetes in southern India JOURNAL Ann. N. Y. Acad. Sci. 958, 293-296 (2002) MEDLINE 22015049 REMARK GeneRIF: BCG vaccination and GAD65 and IA-2 autoantibodies in autoimmune diabetes in southern India. REFERENCE 2 (residues 1 to 979) AUTHORS Kawasaki,E., Yamaguchi,H., Hattori,H., Egashira,T. and Eguchi,K. TITLE Autoantibodies to IA-2 in type 1 diabetes: measurements with a new enzyme-linked immunosorbent assay JOURNAL Ann. N. Y. Acad. Sci. 958, 241-246 (2002) MEDLINE 22015037 REMARK GeneRIF: Autoantibodies to IA-2 in type 1 diabetes: measurements with a new enzyme-linked immunosorbent assay. REFERENCE 3 (residues 1 to 979) AUTHORS Miao,D., Yu,L., Tiberti,C., Cuthbertson,D.D., Rewers,M., di Mario,U., Eisenbarth,G.S. and Dotta,F. TITLE ICA512(IA-2) epitope specific assays distinguish transient from diabetes associated autoantibodies JOURNAL J. Autoimmun. 18 (2), 191-196 (2002) MEDLINE 21906940 REMARK GeneRIF: ICA512(IA-2) epitope specific assays distinguish transient from diabetes associated autoantibodies. REFERENCE 4 (residues 1 to 979) AUTHORS Mikulecky,M. and Michalkova,D. TITLE Secular and seasonal cycling of IA2-ab autoantibody in Slovak diabetic children JOURNAL Biomed. Pharmacother. 55 Suppl 1, 106S-109S (2001) MEDLINE 21630621 REFERENCE 5 (residues 1 to 979) AUTHORS Cui,L., Yu,W.P., DeAizpurua,H.J., Schmidli,R.S. and Pallen,C.J. TITLE Cloning and characterization of islet cell antigen-related protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetes JOURNAL J. Biol. Chem. 271 (40), 24817-24823 (1996) MEDLINE 96394649 REFERENCE 6 (residues 1 to 979) AUTHORS van den Maagdenberg,A.M., Olde Weghuis,D., Rijss,J., van de Wetering,R.A., Wieringa,B., Geurts van Kessel,A. and Hendriks,W.J. TITLE Assignment of the human gene for receptor-type protein tyrosine phosphatase IA-2 (PTPRN) to chromosome region 2q35 --> q36.1 and identification of an intragenic genetic marker JOURNAL Cytogenet. Cell Genet. 73 (1-2), 145-148 (1996) MEDLINE 96244610 REFERENCE 7 (residues 1 to 979) AUTHORS Lan,M.S., Lu,J., Goto,Y. and Notkins,A.L. TITLE Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma JOURNAL DNA Cell Biol. 13 (5), 505-514 (1994) MEDLINE 94296553 REFERENCE 8 (residues 1 to 979) AUTHORS Rabin,D.U., Pleasic,S.M., Shapiro,J.A., Yoo-Warren,H., Oles,J., Hicks,J.M., Goldstein,D.E. and Rae,P.M. TITLE Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases JOURNAL J. Immunol. 152 (6), 3183-3188 (1994) MEDLINE 94194080 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from L18983.1, AF042285.4 and BC007713.1. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hIA2_D1 (NP_002837) PTPRN| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..279 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="2" /map="2q35-q36.1" /vntifkey="269" Protein 1..279 /product="protein tyrosine phosphatase, receptor type, N precursor" /EC_number="3.1.3.48" /vntifkey="270" /note="islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N precursor" Region 1..279 /product="protein tyrosine phosphatase, receptor type, N" /vntifkey="203" /label=Chain_1 Region 17..278 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 hmilaymedh lrnrdrlake wqalcayqae pntcataqge gnikknrhpd flpydharik 61 lkvesspsrs dyinaspiie hdprmpayia tqgplshtia dfwqmvwesg ctvivmltpl 121 vedgvkqcdr ywpdegasly hvyevnlvse hiwcedflvr sfylknvqtq etrtltqfhf 181 lswpaegtpa strplldfrr kvnkcyrgrs cpiivhcsdg agrtgtyili dmvlnrmakg 241 vkeidiaatl ehvrdqrpgl vrskdqfefa ltavaeevn // LOCUS hIA2beta_D 279 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, N polypeptide 2 isoform 1 precursor; protein tyrosine phosphatase receptor pi; phogrin; tyrosine phosphatase IA-2 beta; IAR/receptor-like protein-tyrosine phosphatase [Homo sapiens]. ACCESSION NP_002838 DBSOURCE REFSEQ: accession NM_002847.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 1015) AUTHORS van den Maagdenberg,A.M., Schepens,J.T., Schepens,M.T., Pepers,B., Wieringa,B., van Kessel,A.G. and Hendriks,W.J. TITLE Assignment of Ptprn2, the gene encoding receptor-type protein tyrosine phosphatase IA-2beta, a major autoantigen in insulin-dependent diabetes mellitus, to mouse chromosome region 12F JOURNAL Cytogenet. Cell Genet. 82 (3-4), 153-155 (1998) MEDLINE 99077744 REFERENCE 2 (residues 1 to 1015) AUTHORS Schmidli,R.S., Colman,P.G., Cui,L., Yu,W.P., Kewming,K., Jankulovski,C., Harrison,L.C., Pallen,C.J. and DeAizpurua,H.J. TITLE Antibodies to the protein tyrosine phosphatases IAR and IA-2 are associated with progression to insulin-dependent diabetes (IDDM) in first-degree relatives at-risk for IDDM JOURNAL Autoimmunity 28 (1), 15-23 (1998) MEDLINE 98425805 REFERENCE 3 (residues 1 to 1015) AUTHORS Li,Q., Borovitskaya,A.E., DeSilva,M.G., Wasserfall,C., Maclaren,N.K., Notkins,A.L. and Lan,M.S. TITLE Autoantigens in insulin-dependent diabetes mellitus: molecular cloning and characterization of human IA-2 beta JOURNAL Proc. Assoc. Am. Physicians 109 (4), 429-439 (1997) MEDLINE 97364262 REFERENCE 4 (residues 1 to 1015) AUTHORS Smith,P.D., Barker,K.T., Wang,J., Lu,Y.J., Shipley,J. and Crompton,M.R. TITLE ICAAR, a novel member of a new family of transmembrane, tyrosine phosphatase-like proteins JOURNAL Biochem. Biophys. Res. Commun. 229 (2), 402-411 (1996) MEDLINE 97127415 REFERENCE 5 (residues 1 to 1015) AUTHORS Kawasaki,E., Hutton,J.C. and Eisenbarth,G.S. TITLE Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue, phogrin, an autoantigen of type 1 diabetes JOURNAL Biochem. Biophys. Res. Commun. 227 (2), 440-447 (1996) MEDLINE 97032784 REFERENCE 6 (residues 1 to 1015) AUTHORS Cui,L., Yu,W.P., DeAizpurua,H.J., Schmidli,R.S. and Pallen,C.J. TITLE Cloning and characterization of islet cell antigen-related protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetes JOURNAL J. Biol. Chem. 271 (40), 24817-24823 (1996) MEDLINE 96394649 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U66702.1 and AF007555.1. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. Transcript Variant: This variant (1) encodes the longest isoform (1). COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hIA2beta_D1 (NP_002838) PTPRN2| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..279 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="7" /map="7q36" /vntifkey="269" Protein 1..279 /product="protein tyrosine phosphatase, receptor type, N polypeptide 2 isoform 1 precursor" /vntifkey="270" /note="protein tyrosine phosphatase receptor pi; phogrin; tyrosine phosphatase IA-2 beta; IAR/receptor-like protein-tyrosine phosphatase" Region 1..279 /product="protein tyrosine phosphatase, receptor type, N polypeptide 2, isoform 1" /vntifkey="203" /label=Chain_1 Region 17..278 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 hmilsymedh lknknrleke wealcayqae pnssfvaqre envpknrsla vltydhsrvl 61 lkaenshshs dyinaspimd hdprnpayia tqgplpatva dfwqmvwesg cvvivmltpl 121 aengvrqcyh ywpdegsnly hiyevnlvse hiwcedflvr sfylknlqtn etrtvtqfhf 181 lswydrgvps ssrslldfrr kvnkcyrgrs cpiivhcsdg agrsgtyvli dmvlnkmakg 241 akeidiaatl ehlrdqrpgm vqtkeqfefa ltavaeevn // LOCUS hLAR_D1\(N 275 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, F isoform 1 precursor; protein tyrosine phosphatase, receptor type, F polypeptide; receptor-linked protein-tyrosine phosphatase LAR; leukocyte antigen-related tyrosine phosphatase; LCA-homolog [Homo sapiens]. ACCESSION NP_002831 DBSOURCE REFSEQ: accession NM_002840.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 1897) AUTHORS Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J. TITLE Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases JOURNAL J. Biol. Chem. 277 (49), 47263-47269 (2002) MEDLINE 22344739 REMARK GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are a common but specific mechanism that is likely to be regulated- domain2s and the wedge structures are crucial determinants of binding specificity, thus regulating cross-talk between RPTPs REFERENCE 2 (residues 1 to 1897) AUTHORS Symons,J.R., LeVea,C.M. and Mooney,R.A. TITLE Expression of the leucocyte common antigen-related (LAR) tyrosine phosphatase is regulated by cell density through functional E-cadherin complexes JOURNAL Biochem. J. 365 (Pt 2), 513-519 (2002) MEDLINE 22090243 REMARK GeneRIF: regulation of expression by cell density through functional E-cadherin complexes REFERENCE 3 (residues 1 to 1897) AUTHORS Zabolotny,J.M., Kim,Y.B., Peroni,O.D., Kim,J.K., Pani,M.A., Boss,O., Klaman,L.D., Kamatkar,S., Shulman,G.I., Kahn,B.B. and Neel,B.G. TITLE Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance JOURNAL Proc. Natl. Acad. Sci. U.S.A. 98 (9), 5187-5192 (2001) MEDLINE 21221100 REFERENCE 4 (residues 1 to 1897) AUTHORS Muller,T., Choidas,A., Reichmann,E. and Ullrich,A. TITLE Phosphorylation and free pool of beta-catenin are regulated by tyrosine kinases and tyrosine phosphatases during epithelial cell migration JOURNAL J. Biol. Chem. 274 (15), 10173-10183 (1999) MEDLINE 99214576 REFERENCE 5 (residues 1 to 1897) AUTHORS Ahmad,F. and Goldstein,B.J. TITLE Functional association between the insulin receptor and the transmembrane protein-tyrosine phosphatase LAR in intact cells JOURNAL J. Biol. Chem. 272 (1), 448-457 (1997) MEDLINE 97150746 REFERENCE 6 (residues 1 to 1897) AUTHORS Harder,K.W., Saw,J., Miki,N. and Jirik,F. TITLE Coexisting amplifications of the chromosome 1p32 genes (PTPRF and MYCL1) encoding protein tyrosine phosphatase LAR and L-myc in a small cell lung cancer line JOURNAL Genomics 27 (3), 552-553 (1995) MEDLINE 96047346 REFERENCE 7 (residues 1 to 1897) AUTHORS Schaapveld,R.Q., van den Maagdenberg,A.M., Schepens,J.T., Weghuis,D.O., Geurts van Kessel,A., Wieringa,B. and Hendriks,W.J. TITLE The mouse gene Ptprf encoding the leukocyte common antigen-related molecule LAR: cloning, characterization, and chromosomal localization JOURNAL Genomics 27 (1), 124-130 (1995) MEDLINE 95394448 REFERENCE 8 (residues 1 to 1897) AUTHORS O'Grady,P., Krueger,N.X., Streuli,M. and Saito,H. TITLE Genomic organization of the human LAR protein tyrosine phosphatase gene and alternative splicing in the extracellular fibronectin type-III domains JOURNAL J. Biol. Chem. 269 (40), 25193-25199 (1994) MEDLINE 95014301 REFERENCE 9 (residues 1 to 1897) AUTHORS Streuli,M., Krueger,N.X., Hall,L.R., Schlossman,S.F. and Saito,H. TITLE A new member of the immunoglobulin superfamily that has a cytoplasmic region homologous to the leukocyte common antigen JOURNAL J. Exp. Med. 168 (5), 1523-1530 (1988) MEDLINE 89035978 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Y00815.1 and BI711143.1. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. Transcript Variant: This variant (1) contains an extra internal fragment within the coding region when compared to variant 2. It thus encodes a protein that has a 9 aa internal fragment absent in isoform 2. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hLAR_D1 (NP_002831) PTPRF| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..275 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="1" /map="1p34" /vntifkey="269" Protein 1..275 /product="protein tyrosine phosphatase, receptor type, F isoform 1 precursor" /EC_number="3.1.3.48" /vntifkey="270" /note="protein tyrosine phosphatase, receptor type, F polypeptide; receptor-linked protein-tyrosine phosphatase LAR; leukocyte antigen-related tyrosine phosphatase; LCA-homolog" Region 1..275 /product="protein tyrosine phosphatase, receptor type, F, isoform 1" /vntifkey="203" /label=Chain_1 Region 17..272 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_4 /note="PTPc" ORIGIN 1 tdladnierl kandglkfsq eyesidpgqq ftwensnlev nkpknryanv iaydhsrvil 61 tsidgvpgsd yinanyidgy rkqnayiatq gplpetmgdf wrmvweqrta tvvmmtrlee 121 ksrvkcdqyw pargtetcgl iqvtlldtve latytvrtfa lhksgssekr elrqfqfmaw 181 pdhgvpeypt pilaflrrvk acnpldagpm vvhcsagvgr tgcfividam lermkhektv 241 diyghvtcmr sqrnymvqte dqyvfiheal leaat // LOCUS hLyPTP_D1\ 287 aa 30-JUN-2003 DEFINITION lymphoid-specific protein tyrosine phosphatase isoform 1; lymphoid-specific protein tyrosine phosphatase; protein tyrosine phosphatase homolog [Homo sapiens]. ACCESSION NP_057051 DBSOURCE REFSEQ: accession NM_015967.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 807) AUTHORS Hill,R.J., Zozulya,S., Lu,Y.L., Ward,K., Gishizky,M. and Jallal,B. TITLE The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation JOURNAL Exp. Hematol. 30 (3), 237-244 (2002) MEDLINE 21876996 REMARK GeneRIF: data demonstrate a novel interaction between Lyp and the adaptor Grb2 and are consistent with a negative regulatory role for Lyp in T-cell signaling. REFERENCE 2 (residues 1 to 807) AUTHORS Cohen,S., Dadi,H., Shaoul,E., Sharfe,N. and Roifman,C.M. TITLE Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp JOURNAL Blood 93 (6), 2013-2024 (1999) MEDLINE 99168989 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF077031.1 and AF001846.1. Summary: This gene encodes a protein tyrosine phosphatase which is expressed primarily in lymphoid tissues. This enzyme associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. Transcript Variant: This variant (1) encodes the longer isoform (1) which is 116 aa longer than isoform 2 and has a distinct C-terminus. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hLyPTP_D1 (NP_057051) PTPN22| COMMENT VNTAUTHORNAME|JNA| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..287 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="1" /map="1p13.3-p13.1" /vntifkey="269" Protein 1..287 /product="lymphoid-specific protein tyrosine phosphatase isoform 1" /vntifkey="270" /note="lymphoid-specific protein tyrosine phosphatase; protein tyrosine phosphatase homolog" Region 20..287 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 eilqkfldea qskkitkeef aneflklkrq stkykadkty pttvaekpkn ikknrykdil 61 pydysrvels litsdedssy inanfikgvy gpkayiatqg plsttlldfw rmiweysvli 121 igmacmeyem gkkkcerywa epvemqlefg pfsvsceaek rksdyiirtl kvkfnsetrt 181 iyqfhyknwp dhdvpssidp ileliwdvrc yqeddsvpic ihcsagcgrt gvicaidytw 241 mllkdgiipe nfsvfslire mrtqrpslvq tqeqyelvyn avlelfk // LOCUS hMEG1_D1\( 277 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 4; megakaryocyte phosphatase; PTPase-MEG1; protein tyrosine phosphatase MEG1; megakaryocyte protein-tyrosine phosphatase [Homo sapiens]. ACCESSION NP_002821 DBSOURCE REFSEQ: accession NM_002830.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 926) AUTHORS Hironaka,K., Umemori,H., Tezuka,T., Mishina,M. and Yamamoto,T. TITLE The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor delta 2 and epsilon subunits JOURNAL J. Biol. Chem. 275 (21), 16167-16173 (2000) MEDLINE 20283654 REFERENCE 2 (residues 1 to 926) AUTHORS Gu,M., Meng,K. and Majerus,P.W. TITLE The effect of overexpression of the protein tyrosine phosphatase PTPMEG on cell growth and on colony formation in soft agar in COS-7 cells JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (23), 12980-12985 (1996) MEDLINE 97075104 REFERENCE 3 (residues 1 to 926) AUTHORS Gu,M. and Majerus,P.W. TITLE The properties of the protein tyrosine phosphatase PTPMEG JOURNAL J. Biol. Chem. 271 (44), 27751-27759 (1996) MEDLINE 97066967 REFERENCE 4 (residues 1 to 926) AUTHORS Gu,M.X., York,J.D., Warshawsky,I. and Majerus,P.W. TITLE Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1 JOURNAL Proc. Natl. Acad. Sci. U.S.A. 88 (13), 5867-5871 (1991) MEDLINE 91288564 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M68941.1 and BC010674.1. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hMEG1_D1 (NP_002821) PTPN4| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..277 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="2" /map="2q14.1" /vntifkey="269" Protein 1..277 /product="protein tyrosine phosphatase, non-receptor type 4" /EC_number="3.1.3.48" /vntifkey="270" /note="megakaryocyte phosphatase; PTPase-MEG1; protein tyrosine phosphatase MEG1; megakaryocyte protein-tyrosine phosphatase" Region 19..277 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 hslresmiql aeglitgtvl tqfdqlyrkk pgmtmscakl pqnisknryr dispydatrv 61 ilkgnedyin anyinmeips ssiinqyiac qgplphtctd fwqmtweqgs smvvmlttqv 121 ergrvkchqy wpeptgsssy gcyqvtchse egntayifrk mtlfnqekne srpltqiqyi 181 awpdhgvpdd ssdfldfvch vrnkragkee pvvvhcsagi grtgvlitme tamcliecnq 241 pvypldivrt mrdqrammiq tpsqyrfvce ailkvye // LOCUS hMEG2_D1\( 291 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 9; protein-tyrosine phosphatase MEG2; PTPase-MEG2 [Homo sapiens]. ACCESSION NP_002824 DBSOURCE REFSEQ: accession NM_002833.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 593) AUTHORS Qi,Y., Zhao,R., Cao,H., Sui,X., Krantz,S.B. and Zhao,Z.J. TITLE Purification and characterization of protein tyrosine phosphatase PTP-MEG2 JOURNAL J. Cell. Biochem. 86 (1), 79-89 (2002) MEDLINE 22106294 REMARK GeneRIF: Purification and characterization of protein tyrosine phosphatase PTP-MEG2 REFERENCE 2 (residues 1 to 593) AUTHORS Kruger,J.M., Fukushima,T., Cherepanov,V., Borregaard,N., Loeve,C., Shek,C., Sharma,K., Tanswell,A.K., Chow,C.W. and Downey,G.P. TITLE Protein-tyrosine phosphatase MEG2 is expressed by human neutrophils. Localization to the phagosome and activation by polyphosphoinositides JOURNAL J. Biol. Chem. 277 (4), 2620-2628 (2002) MEDLINE 21659736 REFERENCE 3 (residues 1 to 593) AUTHORS Gu,M., Warshawsky,I. and Majerus,P.W. TITLE Cloning and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to retinaldehyde-binding protein and yeast SEC14p JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (7), 2980-2984 (1992) MEDLINE 92212952 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M83738.1. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by polyphosphoinositide, and is thought to be involved in signaling events regulating phagocytosis. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hMEG2_D1 (NP_002824) PTPN9| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..291 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="15" /map="15q23" /vntifkey="269" Protein 1..291 /product="protein tyrosine phosphatase, non-receptor type 9" /EC_number="3.1.3.48" /vntifkey="270" /note="protein-tyrosine phosphatase MEG2; PTPase-MEG2" Region 17..291 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 mtiqelvdyv narqkqgiye eyedirrenp vgtfhcsmsp gnleknrygd vpcldqtrvk 61 ltkrsghtqt dyinasfmdg ykqknayigt qgplentyrd fwlmvweqkv lvivmttrfe 121 eggrrkcgqy wplekdsrir fgfltvtnlg venmnhykkt tleihnteer qkrqvthfqf 181 lswpdygvps saaslidflr vvrnqqslav snmgarskgq cpeppivvhc sagigrtgtf 241 csldiclaql eelgtlnvfq tvsrmrtqra fsiqtpeqyy fcykailefa e // LOCUS hPCPTP1_D1 275 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, R isoform 1 precursor; protein tyrosine phosphatase, receptor type, Q; protein-tyrosine phosphatase NC-PTPCOM1; protein tyrosine phosphatase Cr1PTPase precursor; Ch-1 PTPase [Homo sapiens]. ACCESSION NP_002840 DBSOURCE REFSEQ: accession NM_002849.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 657) AUTHORS Blanco-Aparicio,C., Torres,J. and Pulido,R. TITLE A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase JOURNAL J. Cell Biol. 147 (6), 1129-1136 (1999) MEDLINE 20069779 REFERENCE 2 (residues 1 to 657) AUTHORS Shiozuka,K., Watanabe,Y., Ikeda,T., Hashimoto,S. and Kawashima,H. TITLE Cloning and expression of PCPTP1 encoding protein tyrosine phosphatase JOURNAL Gene 162 (2), 279-284 (1995) MEDLINE 96032358 REMARK founctional study of the rat homolog REFERENCE 3 (residues 1 to 657) AUTHORS Ogata,M., Sawada,M., Fujino,Y. and Hamaoka,T. TITLE cDNA cloning and characterization of a novel receptor-type protein tyrosine phosphatase expressed predominantly in the brain JOURNAL J. Biol. Chem. 270 (5), 2337-2343 (1995) MEDLINE 95138207 REMARK functional study of the mouse homolog REFERENCE 4 (residues 1 to 657) AUTHORS Sharma,E. and Lombroso,P.J. TITLE A neuronal protein tyrosine phosphatase induced by nerve growth factor JOURNAL J. Biol. Chem. 270 (1), 49-53 (1995) MEDLINE 95113874 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from D64053.1. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domains, and thus represents a receptor-type PTP. The similar gene predominately expressed in mouse brain was found to associate with, and thus regulate the activity and cellular localization of MAP kinases. The rat counterpart of this gene was reported to be regulated by the nerve growth factor, which suggested the function of this gene in neuronal growth and differentiation. Transcript Variant: This variant (1) contains a different 5' end region when compared to variant 2. It thus encodes a protein that has a longer N-terminus, as compared to isoform 2. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hPCPTP1_D1 (NP_002840) PTPRR| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..275 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="12" /map="12q15" /vntifkey="269" Protein 1..275 /product="protein tyrosine phosphatase, receptor type, R isoform 1 precursor" /vntifkey="270" /note="protein tyrosine phosphatase, receptor type, Q; protein-tyrosine phosphatase NC-PTPCOM1; protein tyrosine phosphatase Cr1PTPase precursor; Ch-1 PTPase" Region 1..275 /product="protein tyrosine phosphatase, receptor type, R isoform 1" /vntifkey="203" /label=Chain_1 Region 18..273 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 sriltrsqlr dvvasshllq sefmeipmnf vdpkeidipr hgtknrykti lpnplsrvcl 61 rpknvtdsls tyinanyirg ysgkekafia tqgpmintvd dfwqmvwqed spvivmitkl 121 keknekcvly wpekrgiygk vevlvisvne cdnytirnlv lkqgshtqhv khywytswpd 181 hktpdsaqpl lqlmldveed rlasqgrgpv vvhcsagigr tgcfiatsig cqqlkeegvv 241 dalsivcqlr mdrggmvqts eqyefvhhal clyes // LOCUS hPEST_D1\( 288 aa 3-JUL-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 12; protein-tyrosine phosphatase G1 [Homo sapiens]. ACCESSION NP_002826 DBSOURCE REFSEQ: accession NM_002835.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 780) AUTHORS Lyons,P.D., Dunty,J.M., Schaefer,E.M. and Schaller,M.D. TITLE Inhibition of the catalytic activity of cell adhesion kinase beta by protein-tyrosine phosphatase-PEST-mediated dephosphorylation JOURNAL J. Biol. Chem. 276 (26), 24422-24431 (2001) MEDLINE 21316574 REFERENCE 2 (residues 1 to 780) AUTHORS Cong,F., Spencer,S., Cote,J.F., Wu,Y., Tremblay,M.L., Lasky,L.A. and Goff,S.P. TITLE Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation JOURNAL Mol. Cell 6 (6), 1413-1423 (2000) MEDLINE 21111050 REFERENCE 3 (residues 1 to 780) AUTHORS Shen,Y., Lyons,P., Cooley,M., Davidson,D., Veillette,A., Salgia,R., Griffin,J.D. and Schaller,M.D. TITLE The noncatalytic domain of protein-tyrosine phosphatase-PEST targets paxillin for dephosphorylation in vivo JOURNAL J. Biol. Chem. 275 (2), 1405-1413 (2000) MEDLINE 20092920 REFERENCE 4 (residues 1 to 780) AUTHORS Nishiya,N., Iwabuchi,Y., Shibanuma,M., Cote,J.F., Tremblay,M.L. and Nose,K. TITLE Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain JOURNAL J. Biol. Chem. 274 (14), 9847-9853 (1999) MEDLINE 99194842 REFERENCE 5 (residues 1 to 780) AUTHORS Garton,A.J. and Tonks,N.K. TITLE Regulation of fibroblast motility by the protein tyrosine phosphatase PTP-PEST JOURNAL J. Biol. Chem. 274 (6), 3811-3818 (1999) MEDLINE 99121127 REFERENCE 6 (residues 1 to 780) AUTHORS Takekawa,M., Itoh,F., Hinoda,Y., Adachi,M., Ariyama,T., Inazawa,J., Imai,K. and Yachi,A. TITLE Chromosomal localization of the protein tyrosine phosphatase G1 gene and characterization of the aberrant transcripts in human colon cancer cells JOURNAL FEBS Lett. 339 (3), 222-228 (1994) MEDLINE 94156037 REFERENCE 7 (residues 1 to 780) AUTHORS Yang,Q., Co,D., Sommercorn,J. and Tonks,N.K. TITLE Cloning and expression of PTP-PEST. A novel, human, nontransmembrane protein tyrosine phosphatase JOURNAL J. Biol. Chem. 268 (9), 6622-6628 (1993) MEDLINE 93203262 REFERENCE 8 (residues 1 to 780) AUTHORS Takekawa,M., Itoh,F., Hinoda,Y., Arimura,Y., Toyota,M., Sekiya,M., Adachi,M., Imai,K. and Yachi,A. TITLE Cloning and characterization of a human cDNA encoding a novel putative cytoplasmic protein-tyrosine-phosphatase JOURNAL Biochem. Biophys. Res. Commun. 189 (2), 1223-1230 (1992) MEDLINE 93112015 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M93425.1. On Jan 25, 2002 this sequence version replaced gi:4506287. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may be related to protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of oncogene c-ABL, thus may play a role in oncogenesis. This PTP was shown to interact with, and dephosphorylate, various of cytoskeleton and cell adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin, which suggested its regulatory roles in controlling cell shape and mobility. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hPEST_D1 (NP_002826) PTPN12| COMMENT VNTAUTHORNAME|JNA| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..288 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="7" /map="7q11.23" /vntifkey="269" Protein 1..288 /product="protein tyrosine phosphatase, non-receptor type 12" /EC_number="3.1.3.48" /vntifkey="270" /note="protein-tyrosine phosphatase G1" Region 21..288 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 rkfiqrvqam kspdhngedn fardfmrlrr lstkyrteki yptatgekee nvkknrykdi 61 lpfdhsrvkl tlktpsqdsd yinanfikgv ygpkayvatq gplantvidf wrmiweynvv 121 iivmacrefe mgrkkceryw plygedpitf apfkiscede qartdyfirt lllefqnesr 181 rlyqfhyvnw pdhdvpssfd sildmislmr kyqehedvpi cihcsagcgr tgaicaidyt 241 wnllkagkip eefnvfnliq emrtqrhsav qtkeqyelvh raiaqlfe // LOCUS hPTP1B_D1\ 279 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 1; non-receptor tyrosine phophatase 1; protein tyrosine phophatase 1B; protein tyrosine phophatase, placental [Homo sapiens]. ACCESSION NP_002818 DBSOURCE REFSEQ: accession NM_002827.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 435) AUTHORS Li,S. and Whorton,A.R. TITLE Regulation of protein tyrosine phosphatase 1B in intact cells by S-nitrosothiols JOURNAL Arch. Biochem. Biophys. 410 (2), 269-279 (2003) MEDLINE 22461115 REMARK GeneRIF: PTP1B inhibition by S-nitrosylation is caused by formation of a mixed disulfide REFERENCE 2 (residues 1 to 435) AUTHORS Fukada,T. and Tonks,N.K. TITLE Identification of YB-1 as a regulator of PTP1B expression: implications for regulation of insulin and cytokine signaling JOURNAL EMBO J. 22 (3), 479-493 (2003) MEDLINE 22441887 REMARK GeneRIF: Data show that Y box-binding protein-1 (YB-1) is a regulator of protein tyrosine phosphatase 1B (PTP1B) expression, and highlight PTP1B as a critical regulator of insulin- and cytokine-mediated signal transduction. REFERENCE 3 (residues 1 to 435) AUTHORS Yigzaw,Y., Poppleton,H.M., Sreejayan,N., Hassid,A. and Patel,T.B. TITLE Protein-tyrosine phosphatase-1B (PTP1B) mediates the anti-migratory actions of Sprouty JOURNAL J. Biol. Chem. 278 (1), 284-288 (2003) MEDLINE 22393490 REMARK GeneRIF: Data show that an increase in soluble protein-tyrosine phosphatase 1B activity contributes to the anti-migratory, but not anti-mitogenic, actions of human Sprouty 2. REFERENCE 4 (residues 1 to 435) AUTHORS Di Paola,R., Frittitta,L., Miscio,G., Bozzali,M., Baratta,R., Centra,M., Spampinato,D., Santagati,M.G., Ercolino,T., Cisternino,C., Soccio,T., Mastroianno,S., Tassi,V., Almgren,P., Pizzuti,A., Vigneri,R. and Trischitta,V. TITLE A variation in 3' UTR of hPTP1B increases specific gene expression and associates with insulin resistance JOURNAL Am. J. Hum. Genet. 70 (3), 806-812 (2002) MEDLINE 21832513 REMARK GeneRIF: variation in 3' UTR of hPTP1B increases specific gene expression and associates with insulin resistance REFERENCE 5 (residues 1 to 435) AUTHORS Myers,M.P., Andersen,J.N., Cheng,A., Tremblay,M.L., Horvath,C.M., Parisien,J.P., Salmeen,A., Barford,D. and Tonks,N.K. TITLE TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B JOURNAL J. Biol. Chem. 276 (51), 47771-47774 (2001) MEDLINE 21611285 REFERENCE 6 (residues 1 to 435) AUTHORS Wang,J., Cheung,A.T., Kolls,J.K., Starks,W.W., Martinez-Hernandez,A., Dietzen,D. and Bryer-Ash,M. TITLE Effects of adenovirus-mediated liver-selective overexpression of protein tyrosine phosphatase-1b on insulin sensitivity in vivo JOURNAL Diabetes Obes Metab 3 (5), 367-380 (2001) MEDLINE 21560532 REMARK GeneRIF: Moderate overabundance of PTP-1B in liver tissue does not alter insulin action on glucose metabolism, and the site of action of PTP-1B is presumably at insulin-responsive target tissue or tissues other than the liver. REFERENCE 7 (residues 1 to 435) AUTHORS Dadke,S., Kusari,A. and Kusari,J. TITLE Phosphorylation and activation of protein tyrosine phosphatase (PTP) 1B by insulin receptor JOURNAL Mol. Cell. Biochem. 221 (1-2), 147-154 (2001) MEDLINE 21396990 REFERENCE 8 (residues 1 to 435) AUTHORS Egawa,K., Maegawa,H., Shimizu,S., Morino,K., Nishio,Y., Bryer-Ash,M., Cheung,A.T., Kolls,J.K., Kikkawa,R. and Kashiwagi,A. TITLE Protein-tyrosine phosphatase-1B negatively regulates insulin signaling in l6 myocytes and Fao hepatoma cells JOURNAL J. Biol. Chem. 276 (13), 10207-10211 (2001) MEDLINE 21167830 REFERENCE 9 (residues 1 to 435) AUTHORS Salmeen,A., Andersen,J.N., Myers,M.P., Tonks,N.K. and Barford,D. TITLE Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B JOURNAL Mol. Cell 6 (6), 1401-1412 (2000) MEDLINE 21111049 REFERENCE 10 (residues 1 to 435) AUTHORS Peters,G.H., Iversen,L.F., Branner,S., Andersen,H.S., Mortensen,S.B., Olsen,O.H., Moller,K.B. and Moller,N.P. TITLE Residue 259 is a key determinant of substrate specificity of protein-tyrosine phosphatases 1B and alpha JOURNAL J. Biol. Chem. 275 (24), 18201-18209 (2000) MEDLINE 20309769 REFERENCE 11 (residues 1 to 435) AUTHORS Ahmad,F., Li,P.M., Meyerovitch,J. and Goldstein,B.J. TITLE Osmotic loading of neutralizing antibodies demonstrates a role for protein-tyrosine phosphatase 1B in negative regulation of the insulin action pathway JOURNAL J. Biol. Chem. 270 (35), 20503-20508 (1995) MEDLINE 95386495 REFERENCE 12 (residues 1 to 435) AUTHORS Milarski,K.L., Zhu,G., Pearl,C.G., McNamara,D.J., Dobrusin,E.M., MacLean,D., Thieme-Sefler,A., Zhang,Z.Y., Sawyer,T., Decker,S.J. et al. TITLE Sequence specificity in recognition of the epidermal growth factor receptor by protein tyrosine phosphatase 1B JOURNAL J. Biol. Chem. 268 (31), 23634-23639 (1993) MEDLINE 94043167 REFERENCE 13 (residues 1 to 435) AUTHORS Brown-Shimer,S., Johnson,K.A., Lawrence,J.B., Johnson,C., Bruskin,A., Green,N.R. and Hill,D.E. TITLE Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (13), 5148-5152 (1990) MEDLINE 90311360 REFERENCE 14 (residues 1 to 435) AUTHORS Chernoff,J., Schievella,A.R., Jost,C.A., Erikson,R.L. and Neel,B.G. TITLE Cloning of a cDNA for a major human protein-tyrosine-phosphatase JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (7), 2735-2739 (1990) MEDLINE 90207272 REFERENCE 15 (residues 1 to 435) AUTHORS Charbonneau,H., Tonks,N.K., Kumar,S., Diltz,C.D., Harrylock,M., Cool,D.E., Krebs,E.G., Fischer,E.H. and Walsh,K.A. TITLE Human placenta protein-tyrosine-phosphatase: amino acid sequence and relationship to a family of receptor-like proteins JOURNAL Proc. Natl. Acad. Sci. U.S.A. 86 (14), 5252-5256 (1989) MEDLINE 89315775 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M33689.1 and AU117677.1. Summary: The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hPTP1B_D1 (NP_002818) PTPN1| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..279 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="20" /map="20q13.1-q13.2" /vntifkey="269" Protein 1..279 /product="protein tyrosine phosphatase, non-receptor type 1" /EC_number="3.1.3.48" /vntifkey="270" /note="non-receptor tyrosine phophatase 1; protein tyrosine phophatase 1B; protein tyrosine phophatase, placental" Region 3..279 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 memekefeqi dksgswaaiy qdirheasdf pcrvaklpkn knrnryrdvs pfdhsriklh 61 qedndyinas likmeeaqrs yiltqgplpn tcghfwemvw eqksrgvvml nrvmekgslk 121 caqywpqkee kemifedtnl kltlisedik syytvrqlel enlttqetre ilhfhyttwp 181 dfgvpespas flnflfkvre sgslspehgp vvvhcsagig rsgtfcladt clllmdkrkd 241 pssvdikkvl lemrkfrmgl iqtadqlrfs ylaviegak // LOCUS hPTPalpha_ 280 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, A isoform 1 precursor; protein tyrosine phosphatase, receptor type, alpha polypeptide; PTPase-alpha; Leukocyte common antigen-related peptide (protein tyrosine phosphate); tyrosine phosphatase alpha; PTPLCA-related phosphatase [Homo sapiens]. ACCESSION NP_002827 DBSOURCE REFSEQ: accession NM_002836.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 802) AUTHORS Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J. TITLE Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases JOURNAL J. Biol. Chem. 277 (49), 47263-47269 (2002) MEDLINE 22344739 REMARK GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are a common but specific mechanism that is likely to be regulated- domain2s and the wedge structures are crucial determinants of binding specificity, thus regulating cross-talk between RPTPs REFERENCE 2 (residues 1 to 802) AUTHORS Mustelin,T. and Hunter,T. TITLE Meeting at mitosis: cell cycle-specific regulation of c-Src by RPTPalpha JOURNAL Sci STKE 2002 (115), PE3 (2002) MEDLINE 21655780 REMARK GeneRIF: In entering mitosis the cell cycle-specific regulation of c-Src by RPTPalpha can occur by dephosphorylation of phospho-Tyr527 that activates c-Src in a reaction catalyzed by the transmembrane receptor-like protein tyrosine phosphatase RPTPalpha. REFERENCE 3 (residues 1 to 802) AUTHORS Ardini,E., Agresti,R., Tagliabue,E., Greco,M., Aiello,P., Yang,L.T., Menard,S. and Sap,J. TITLE Expression of protein tyrosine phosphatase alpha (RPTPalpha) in human breast cancer correlates with low tumor grade, and inhibits tumor cell growth in vitro and in vivo JOURNAL Oncogene 19 (43), 4979-4987 (2000) MEDLINE 20499263 REFERENCE 4 (residues 1 to 802) AUTHORS Peters,G.H., Iversen,L.F., Branner,S., Andersen,H.S., Mortensen,S.B., Olsen,O.H., Moller,K.B. and Moller,N.P. TITLE Residue 259 is a key determinant of substrate specificity of protein-tyrosine phosphatases 1B and alpha JOURNAL J. Biol. Chem. 275 (24), 18201-18209 (2000) MEDLINE 20309769 REFERENCE 5 (residues 1 to 802) AUTHORS Harder,K.W., Moller,N.P., Peacock,J.W. and Jirik,F.R. TITLE Protein-tyrosine phosphatase alpha regulates Src family kinases and alters cell-substratum adhesion JOURNAL J. Biol. Chem. 273 (48), 31890-31900 (1998) MEDLINE 99041953 REFERENCE 6 (residues 1 to 802) AUTHORS Zheng,X.M., Wang,Y. and Pallen,C.J. TITLE Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase JOURNAL Nature 359 (6393), 336-339 (1992) MEDLINE 93024881 REFERENCE 7 (residues 1 to 802) AUTHORS Rao,V.V., Loffler,C., Sap,J., Schlessinger,J. and Hansmann,I. TITLE The gene for receptor-linked protein-tyrosine-phosphatase (PTPA) is assigned to human chromosome 20p12-pter by in situ hybridization (ISH and FISH) JOURNAL Genomics 13 (3), 906-907 (1992) MEDLINE 92347910 REFERENCE 8 (residues 1 to 802) AUTHORS Ohagi,S., Nishi,M. and Steiner,D.F. TITLE Sequence of a cDNA encoding human LRP (leukocyte common antigen-related peptide) JOURNAL Nucleic Acids Res. 18 (23), 7159 (1990) MEDLINE 91088320 REFERENCE 9 (residues 1 to 802) AUTHORS Jirik,F.R., Janzen,N.M., Melhado,I.G. and Harder,K.W. TITLE Cloning and chromosomal assignment of a widely expressed human receptor-like protein-tyrosine phosphatase JOURNAL FEBS Lett. 273 (1-2), 239-242 (1990) MEDLINE 91032191 REFERENCE 10 (residues 1 to 802) AUTHORS Krueger,N.X., Streuli,M. and Saito,H. TITLE Structural diversity and evolution of human receptor-like protein tyrosine phosphatases JOURNAL EMBO J. 9 (10), 3241-3252 (1990) MEDLINE 91006018 REFERENCE 11 (residues 1 to 802) AUTHORS Kaplan,R., Morse,B., Huebner,K., Croce,C., Howk,R., Ravera,M., Ricca,G., Jaye,M. and Schlessinger,J. TITLE Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (18), 7000-7004 (1990) MEDLINE 90384936 REFERENCE 12 (residues 1 to 802) AUTHORS Sap,J., D'Eustachio,P., Givol,D. and Schlessinger,J. TITLE Cloning and expression of a widely expressed receptor tyrosine phosphatase JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (16), 6112-6116 (1990) MEDLINE 90349565 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M34668.1 and AI284972.1. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. Transcript Variant: This variant (1) contains a unique 5' UTR region when compared to other variants. The genomic exons forming the 5' end region of this transcript are also used to form an internal coding region in the transcripts of VPS16, a distinct gene located at the locus immediately upstream of this gene on chromosome 20. This variant encodes the longest isoform (1). COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hPTPalpha_D1 (NP_002827) PTPRA| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..280 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="20" /map="20p13" /vntifkey="269" Protein 1..280 /product="protein tyrosine phosphatase, receptor type, A isoform 1 precursor" /EC_number="3.1.3.48" /vntifkey="270" /note="protein tyrosine phosphatase, receptor type, alpha polypeptide; PTPase-alpha; Leukocyte common antigen-related peptide (protein tyrosine phosphate); tyrosine phosphatase alpha; PTPLCA-related phosphatase" Region 1..280 /product="protein tyrosine phosphatase, receptor type, A, isoform 1" /vntifkey="203" /label=Chain_1 Region 17..280 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 dkleeeinrr maddnklfre efnalpacpi qatceaaske enkeknryvn ilpydhsrvh 61 ltpvegvpds dyinasfing yqeknkfiaa qgpkeetvnd fwrmiweqnt ativmvtnlk 121 erkeckcaqy wpdqgcwtyg nirvsvedvt vlvdytvrkf ciqqvgdmtn rkpqrlitqf 181 hftswpdfgv pftpigmlkf lkkvkacnpq yagaivvhcs agvgrtgtfv vidamldmmh 241 terkvdvygf vsriraqrcq mvqtdmqyvf iyqallehyl // LOCUS hPTPBAS_D1 275 aa 30-JUN-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 13 isoform 2; protein tyrosine phosphatase, nonreceptor type 13; protein tyrosine phosphatase 1E; Fas-associated phosphatase-1; protein-tyrosine phosphatase 1, Fas-associated; protein-tyrosine phophatase PTPL1; APO-1/CD95 (Fas)-associated phosphatase [Homo sapiens]. ACCESSION NP_006255 DBSOURCE REFSEQ: accession NM_006264.1 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 2466) AUTHORS Yoshida,S., Harada,H., Nagai,H., Fukino,K., Teramoto,A. and Emi,M. TITLE Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and seven polymorphisms of the FAP-1 gene JOURNAL J. Hum. Genet. 47 (11), 614-619 (2002) MEDLINE 22323362 REMARK GeneRIF: Shares a promoter region with the tightly linked gene encoding stress-activated protein kinase JNK3. REFERENCE 2 (residues 1 to 2466) AUTHORS Bompard,G., Puech,C., Prebois,C., Vignon,F. and Freiss,G. TITLE Protein-tyrosine phosphatase PTPL1/FAP-1 triggers apoptosis in human breast cancer cells JOURNAL J. Biol. Chem. 277 (49), 47861-47869 (2002) MEDLINE 22344658 REMARK GeneRIF: PTPL1/FAP-1 has a key role in the apoptotic process in human breast cancer cells independent of Fas but associated with an early inhibition of the insulin receptor substrate-1/phosphatidylinositol 3-kinase pathway REFERENCE 3 (residues 1 to 2466) AUTHORS Kozlov,G., Banville,D., Gehring,K. and Ekiel,I. TITLE Solution structure of the PDZ2 domain from cytosolic human phosphatase hPTP1E complexed with a peptide reveals contribution of the beta2-beta3 loop to PDZ domain-ligand interactions JOURNAL J. Mol. Biol. 320 (4), 813-820 (2002) MEDLINE 22090786 REMARK GeneRIF: PDZ2 domain from cytosolic human phosphatase hPTP1E complexed with peptide, RA-GEF-2, reveals contribution of the beta2-beta3 loop to PDZ domain-ligand interactions REFERENCE 4 (residues 1 to 2466) AUTHORS Walma,T., Spronk,C.A., Tessari,M., Aelen,J., Schepens,J., Hendriks,W. and Vuister,G.W. TITLE Structure, dynamics and binding characteristics of the second PDZ domain of PTP-BL JOURNAL J. Mol. Biol. 316 (5), 1101-1110 (2002) MEDLINE 21881810 REMARK GeneRIF: Structure, dynamics and binding characteristics of the second PDZ domain of PTP-BL REFERENCE 5 (residues 1 to 2466) AUTHORS Marin,L., Minguela,A., Moya-Quiles,M.R., Torio,A., Muro,M., Garcia-Alonso,A.M., Sanchez-Bueno,F., Bru,M., Parrilla,P. and Alvarez-Lopez,M.R. TITLE Expression of CD95 and apoptosis induction in peripheral blood cells from liver graft recipients JOURNAL Transplant. Proc. 34 (1), 280-282 (2002) MEDLINE 21957524 REMARK GeneRIF: expression and apoptosis induction in peripheral blood cells from liver graft REFERENCE 6 (residues 1 to 2466) AUTHORS Nakai,Y., Irie,S. and Sato,T.A. TITLE Identification of IkappaBalpha as a substrate of Fas-associated phosphatase-1 JOURNAL Eur. J. Biochem. 267 (24), 7170-7175 (2000) MEDLINE 20558254 REFERENCE 7 (residues 1 to 2466) AUTHORS Irie,S., Hachiya,T., Rabizadeh,S., Maruyama,W., Mukai,J., Li,Y., Reed,J.C., Bredesen,D.E. and Sato,T.A. TITLE Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation JOURNAL FEBS Lett. 460 (2), 191-198 (1999) MEDLINE 20012928 REFERENCE 8 (residues 1 to 2466) AUTHORS Maekawa,K., Imagawa,N., Naito,A., Harada,S., Yoshie,O. and Takagi,S. TITLE Association of protein-tyrosine phosphatase PTP-BAS with the transcription-factor-inhibitory protein IkappaBalpha through interaction between the PDZ1 domain and ankyrin repeats JOURNAL Biochem. J. 337 (Pt 2), 179-184 (1999) MEDLINE 99102074 REFERENCE 9 (residues 1 to 2466) AUTHORS Saras,J., Franzen,P., Aspenstrom,P., Hellman,U., Gonez,L.J. and Heldin,C.H. TITLE A novel GTPase-activating protein for Rho interacts with a PDZ domain of the protein-tyrosine phosphatase PTPL1 JOURNAL J. Biol. Chem. 272 (39), 24333-24338 (1997) MEDLINE 97450957 REFERENCE 10 (residues 1 to 2466) AUTHORS Saras,J., Engstrom,U., Gonez,L.J. and Heldin,C.H. TITLE Characterization of the interactions between PDZ domains of the protein-tyrosine phosphatase PTPL1 and the carboxyl-terminal tail of Fas JOURNAL J. Biol. Chem. 272 (34), 20979-20981 (1997) MEDLINE 97407871 REFERENCE 11 (residues 1 to 2466) AUTHORS Yanagisawa,J., Takahashi,M., Kanki,H., Yano-Yanagisawa,H., Tazunoki,T., Sawa,E., Nishitoba,T., Kamishohara,M., Kobayashi,E., Kataoka,S. and Sato,T. TITLE The molecular interaction of Fas and FAP-1. A tripeptide blocker of human Fas interaction with FAP-1 promotes Fas-induced apoptosis JOURNAL J. Biol. Chem. 272 (13), 8539-8545 (1997) MEDLINE 97236811 REFERENCE 12 (residues 1 to 2466) AUTHORS Inazawa,J., Ariyama,T., Abe,T., Druck,T., Ohta,M., Huebner,K., Yanagisawa,J., Reed,J.C. and Sato,T. TITLE PTPN13, a fas-associated protein tyrosine phosphatase, is located on the long arm of chromosome 4 at band q21.3 JOURNAL Genomics 31 (2), 240-242 (1996) MEDLINE 96422192 REFERENCE 13 (residues 1 to 2466) AUTHORS Sato,T., Irie,S., Kitada,S. and Reed,J.C. TITLE FAP-1: a protein tyrosine phosphatase that associates with Fas JOURNAL Science 268 (5209), 411-415 (1995) MEDLINE 95232528 REFERENCE 14 (residues 1 to 2466) AUTHORS Saras,J., Claesson-Welsh,L., Heldin,C.H. and Gonez,L.J. TITLE Cloning and characterization of PTPL1, a protein tyrosine phosphatase with similarities to cytoskeletal-associated proteins JOURNAL J. Biol. Chem. 269 (39), 24082-24089 (1994) MEDLINE 95014139 REFERENCE 15 (residues 1 to 2466) AUTHORS Banville,D., Ahmad,S., Stocco,R. and Shen,S.H. TITLE A novel protein-tyrosine phosphatase with homology to both the cytoskeletal proteins of the band 4.1 family and junction-associated guanylate kinases JOURNAL J. Biol. Chem. 269 (35), 22320-22327 (1994) MEDLINE 94350988 REFERENCE 16 (residues 1 to 2466) AUTHORS Maekawa,K., Imagawa,N., Nagamatsu,M. and Harada,S. TITLE Molecular cloning of a novel protein-tyrosine phosphatase containing a membrane-binding domain and GLGF repeats JOURNAL FEBS Lett. 337 (2), 200-206 (1994) MEDLINE 94116679 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from D21210.1. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as IkappaBalpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. Transcript Variant: This variant (2) lacks an internal fragment within the coding region when compared to variant 4. The translation remains in frame, and the encoded protein lacks internal 19 aa, as compared to isoform 4. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hPTPBAS_D1 (NP_006255) PTPN13| COMMENT VNTAUTHORNAME|JNA| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 4..275 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="4" /map="4q21.3" /vntifkey="269" Protein 4..275 /product="protein tyrosine phosphatase, non-receptor type 13 isoform 2" /EC_number="3.1.3.48" /vntifkey="270" /note="protein tyrosine phosphatase, nonreceptor type 13; protein tyrosine phosphatase 1E; Fas-associated phosphatase-1; protein-tyrosine phosphatase 1, Fas-associated; protein-tyrosine phophatase PTPL1; APO-1/CD95 (Fas)-associated phosphatase" Region 20..274 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_2 /note="PTPc" ORIGIN 1 anlksvirvl rglldqgips kelenlqelk pldqcligqt kenrrknryk nilpydatrv 61 plgdeggyin asfikipvgk eefvyiacqg plpttvgdfw qmiweqkstv iammtqeveg 121 ekikcqrywp nilgkttmvs nrlrlalvrm qqlkgfvvra mtlediqtre vrhishlnft 181 awpdhdtpsq pddlltfisy mrhihrsgpi ithcsagigr sgtlicidvv lglisqdldf 241 disdlvrcmr lqrhgmvqte dqyifcyqvi lyvlt // LOCUS hPTPbeta_D 280 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, B precursor; protein tyrosine phosphatase, receptor type, beta polypeptide; protein tyrosine phosphatase beta [Homo sapiens]. ACCESSION NP_002828 DBSOURCE REFSEQ: accession NM_002837.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 1997) AUTHORS Adamsky,K., Schilling,J., Garwood,J., Faissner,A. and Peles,E. TITLE Glial tumor cell adhesion is mediated by binding of the FNIII domain of receptor protein tyrosine phosphatase beta (RPTPbeta) to tenascin C JOURNAL Oncogene 20 (5), 609-618 (2001) MEDLINE 21214455 REFERENCE 2 (residues 1 to 1997) AUTHORS Ratcliffe,C.F., Qu,Y., McCormick,K.A., Tibbs,V.C., Dixon,J.E., Scheuer,T. and Catterall,W.A. TITLE A sodium channel signaling complex: modulation by associated receptor protein tyrosine phosphatase beta JOURNAL Nat. Neurosci. 3 (5), 437-444 (2000) MEDLINE 20233995 REFERENCE 3 (residues 1 to 1997) AUTHORS Sakurai,T., Lustig,M., Nativ,M., Hemperly,J.J., Schlessinger,J., Peles,E. and Grumet,M. TITLE Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta JOURNAL J. Cell Biol. 136 (4), 907-918 (1997) MEDLINE 97201469 REFERENCE 4 (residues 1 to 1997) AUTHORS Peles,E., Nativ,M., Campbell,P.L., Sakurai,T., Martinez,R., Lev,S., Clary,D.O., Schilling,J., Barnea,G., Plowman,G.D. et al. TITLE The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin JOURNAL Cell 82 (2), 251-260 (1995) MEDLINE 95354206 REFERENCE 5 (residues 1 to 1997) AUTHORS Harder,K.W., Anderson,L.L., Duncan,A.M. and Jirik,F.R. TITLE The gene for receptor-like protein tyrosine phosphatase (PTPRB) is assigned to chromosome 12q15-->q21 JOURNAL Cytogenet. Cell Genet. 61 (4), 269-270 (1992) MEDLINE 93137605 REFERENCE 6 (residues 1 to 1997) AUTHORS Krueger,N.X., Streuli,M. and Saito,H. TITLE Structural diversity and evolution of human receptor-like protein tyrosine phosphatases JOURNAL EMBO J. 9 (10), 3241-3252 (1990) MEDLINE 91006018 REFERENCE 7 (residues 1 to 1997) AUTHORS Kaplan,R., Morse,B., Huebner,K., Croce,C., Howk,R., Ravera,M., Ricca,G., Jaye,M. and Schlessinger,J. TITLE Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (18), 7000-7004 (1990) MEDLINE 90384936 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X54131.1 and BE042873.1. On Feb 4, 2002 this sequence version replaced gi:4506305. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hPTPbeta_D1 (NP_002828) PTPRB| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..280 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="12" /map="12q15-q21" /vntifkey="269" Protein 1..280 /product="protein tyrosine phosphatase, receptor type, B precursor" /EC_number="3.1.3.48" /vntifkey="270" /note="protein tyrosine phosphatase, receptor type, beta polypeptide; protein tyrosine phosphatase beta" Region 1..280 /product="protein tyrosine phosphatase, receptor type, B" /EC_number="3.1.3.48" /vntifkey="203" /label=Chain_1 Region 17..280 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 nqfeghfmkl qadsnyllsk eyeelkdvgr nqscdiallp enrgknrynn ilpydatrvk 61 lsnvdddpcs dyinasyipg nnfrreyivt qgplpgtkdd fwkmvweqnv hnivmvtqcv 121 ekgrvkcdhy wpadqdslyy gdlilqmlse svlpewtire fkicgeeqld ahrlirhfhy 181 tvwpdhgvpe ttqsliqfvr tvrdyinrsp gagptvvhcs agvgrtgtfi aldrilqqld 241 skdsvdiyga vhdlrlhrvh mvqtecqyvy lhqcvrdvlr // LOCUS hPTPD1_D1\ 292 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 21; protein tyrosine phosphatase D1 [Homo sapiens]. ACCESSION NP_008970 DBSOURCE REFSEQ: accession NM_007039.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 1174) AUTHORS Jui,H.Y., Tseng,R.J., Wen,X., Fang,H.I., Huang,L.M., Chen,K.Y., Kung,H.J., Ann,D.K. and Shih,H.M. TITLE Protein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases JOURNAL J. Biol. Chem. 275 (52), 41124-41132 (2000) MEDLINE 20576274 REFERENCE 2 (residues 1 to 1174) AUTHORS Tokuchi,H., Higashitsuji,H., Nishiyama,H., Nonoguchi,K., Nagao,T., Xue,J.H., Itoh,K., Ogawa,O. and Fujita,J. TITLE Expression of protein tyrosine phosphatase PTP-RL10 and its isoform in the mouse testis JOURNAL Int J Urol 6 (11), 572-577 (1999) MEDLINE 20049818 REFERENCE 3 (residues 1 to 1174) AUTHORS Higashitsuji,H., Arii,S., Furutani,M., Imamura,M., Kaneko,Y., Takenawa,J., Nakayama,H. and Fujita,J. TITLE Enhanced expression of multiple protein tyrosine phosphatases in the regenerating mouse liver: isolation of PTP-RL10, a novel cytoplasmic-type phosphatase with sequence homology to cytoskeletal protein 4.1 JOURNAL Oncogene 10 (2), 407-414 (1995) MEDLINE 95140431 REFERENCE 4 (residues 1 to 1174) AUTHORS Moller,N.P., Moller,K.B., Lammers,R., Kharitonenkov,A., Sures,I. and Ullrich,A. TITLE Src kinase associates with a member of a distinct subfamily of protein-tyrosine phosphatases containing an ezrin-like domain JOURNAL Proc. Natl. Acad. Sci. U.S.A. 91 (16), 7477-7481 (1994) MEDLINE 94329538 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X79510.1 and AI800682.1. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hPTPD1_D1 (NP_008970) PTPN21| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..292 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="14" /map="14q31.3" /vntifkey="269" Protein 1..292 /product="protein tyrosine phosphatase, non-receptor type 21" /EC_number="3.1.3.48" /vntifkey="270" /note="protein tyrosine phosphatase D1" Region 18..292 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_2 /note="PTPc" ORIGIN 1 atnderckil eqrleqgmvf teyerilkkr lvdgecstar lpenaernrf qdvlpyddar 61 velvptkenn tgyinashik vsvsgiewdy iatqgplqnt cqdfwqmvwe qgiaiiamvt 121 aeeeggreks frywprlgsr hntvtygrfk ittrfrtdsg cyattglkmk hlltgqertv 181 whlqytdwpe hgcpedlkgf lsyleeiqsv rrhtnstsdp qspnppllvh csagvgrtgv 241 vilseimiac lehnevldip rvldmlrqqr mmlvqtlcqy tfvyrvliqf lk // LOCUS hPTPD2_D1\ 292 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 14; cytoskeletal-associated protein tyrosine phosphatase [Homo sapiens]. ACCESSION NP_005392 DBSOURCE REFSEQ: accession NM_005401.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 1187) AUTHORS Wadham,C., Gamble,J.R., Vadas,M.A. and Khew-Goodall,Y. TITLE Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to the nucleus is associated with induction of cell proliferation JOURNAL J. Cell. Sci. 113 (Pt 17), 3117-3123 (2000) MEDLINE 20394014 REFERENCE 2 (residues 1 to 1187) AUTHORS Aoyama,K., Matsuda,T. and Aoki,N. TITLE Characterization of newly identified four isoforms for a putative cytosolic protein tyrosine phosphatase PTP36 JOURNAL Biochem. Biophys. Res. Commun. 266 (2), 523-531 (1999) MEDLINE 20068798 REFERENCE 3 (residues 1 to 1187) AUTHORS Ogata,M., Takada,T., Mori,Y., Uchida,Y., Miki,T., Okuyama,A., Kosugi,A., Sawada,M., Oh-hora,M. and Hamaoka,T. TITLE Regulation of phosphorylation level and distribution of PTP36, a putative protein tyrosine phosphatase, by cell-substrate adhesion JOURNAL J. Biol. Chem. 274 (29), 20717-20724 (1999) MEDLINE 99329094 REFERENCE 4 (residues 1 to 1187) AUTHORS Ogata,M., Takada,T., Mori,Y., Oh-hora,M., Uchida,Y., Kosugi,A., Miyake,K. and Hamaoka,T. TITLE Effects of overexpression of PTP36, a putative protein tyrosine phosphatase, on cell adhesion, cell growth, and cytoskeletons in HeLa cells JOURNAL J. Biol. Chem. 274 (18), 12905-12909 (1999) MEDLINE 99230323 REFERENCE 5 (residues 1 to 1187) AUTHORS Smith,A.L., Mitchell,P.J., Shipley,J., Gusterson,B.A., Rogers,M.V. and Crompton,M.R. TITLE Pez: a novel human cDNA encoding protein tyrosine phosphatase- and ezrin-like domains JOURNAL Biochem. Biophys. Res. Commun. 209 (3), 959-965 (1995) MEDLINE 95251727 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X82676.1 and BC017300.1. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. The specific function of this PTP has not yet been determined. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hPTPD2_D1 (NP_005392) PTPN14| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..292 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="1" /map="1q32.2" /vntifkey="269" Protein 1..292 /product="protein tyrosine phosphatase, non-receptor type 14" /EC_number="3.1.3.48" /vntifkey="270" /note="cytoskeletal-associated protein tyrosine phosphatase" Region 18..292 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_2 /note="PTPc" ORIGIN 1 vpmderfrtl kkkleegmvf teyeqipkkk angifstaal penaersrir evvpyeenrv 61 eliptkennt gyinashikv vvggaewhyi atqgplphtc hdfwqmvweq gvnviamvta 121 eeeggrtksh rywpklgskh ssatygkfkv ttkfrtdsvc yattglkvkh llsgqertvw 181 hlqytdwpdh gcpedvqgfl syleeiqsvr rhtnsmlegt knrhppivvh csagvgrtgv 241 lilselmiyc lehnekvevp mmlrllreqr mfmiqtiaqy kfvyqvliqf lq // LOCUS hPTPdelta\ 275 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, D isoform 1 precursor; protein tyrosine phosphatase, receptor type, delta polypeptide; protein tyrosine phosphatase delta [Homo sapiens]. ACCESSION NP_002830 DBSOURCE REFSEQ: accession NM_002839.1 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 1912) AUTHORS Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J. TITLE Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases JOURNAL J. Biol. Chem. 277 (49), 47263-47269 (2002) MEDLINE 22344739 REMARK GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are a common but specific mechanism that is likely to be regulated- domain2s and the wedge structures are crucial determinants of binding specificity, thus regulating cross-talk between RPTPs REFERENCE 2 (residues 1 to 1912) AUTHORS Pulido,R., Serra-Pages,C., Tang,M. and Streuli,M. TITLE The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1 JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (25), 11686-11690 (1995) MEDLINE 96102179 REFERENCE 3 (residues 1 to 1912) AUTHORS Pulido,R., Krueger,N.X., Serra-Pages,C., Saito,H. and Streuli,M. TITLE Molecular characterization of the human transmembrane protein-tyrosine phosphatase delta. Evidence for tissue-specific expression of alternative human transmembrane protein-tyrosine phosphatase delta isoforms JOURNAL J. Biol. Chem. 270 (12), 6722-6728 (1995) MEDLINE 95204468 REFERENCE 4 (residues 1 to 1912) AUTHORS Krueger,N.X., Streuli,M. and Saito,H. TITLE Structural diversity and evolution of human receptor-like protein tyrosine phosphatases JOURNAL EMBO J. 9 (10), 3241-3252 (1990) MEDLINE 91006018 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from L38929.1. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chick and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple tissue specific alternatively spliced transcript variants of this gene have been reported. Transcript Variant: This variant (1) encodes the longest isoform (1). COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hPTPdelta _D1 (NP_002830) PTPRD| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..275 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="9" /map="9p23-p24.3" /vntifkey="269" Protein 1..275 /product="protein tyrosine phosphatase, receptor type, D isoform 1 precursor" /EC_number="3.1.3.48" /vntifkey="270" /note="protein tyrosine phosphatase, receptor type, delta polypeptide; protein tyrosine phosphatase delta" Region 1..275 /product="protein tyrosine phosphatase, receptor type, D, isoform 1" /vntifkey="203" /label=Chain_1 Region 17..274 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_4 /note="PTPc" ORIGIN 1 leladhierl kandnlkfsq eyesidpgqq ftwehsnlev nkpknryanv iaydhsrvll 61 saiegipgsd yvnanyidgy rkqnayiatq gslpetfgdf wrmiweqrsa tvvmmtklee 121 rsrvkcdqyw psrgtethgl vqvtlldtve latycvrtfa lykngssekr evrqfqftaw 181 pdhgvpehpt pflaflrrvk tcnppdagpm vvhcsagvgr tgcfividam lerikhektv 241 diyghvtlmr aqrnymvqte dqyifihdal leavt // LOCUS hPTPepsilo 279 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, E isoform 1 precursor; protein tyrosine phosphatase, receptor type, epsilon; protein tyrosine phosphatase, receptor type, epsilon polypeptide; protein tyrosine phosphatase epsilon [Homo sapiens]. ACCESSION NP_006495 DBSOURCE REFSEQ: accession NM_006504.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 700) AUTHORS Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J. TITLE Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases JOURNAL J. Biol. Chem. 277 (49), 47263-47269 (2002) MEDLINE 22344739 REMARK GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are a common but specific mechanism that is likely to be regulated- domain2s and the wedge structures are crucial determinants of binding specificity, thus regulating cross-talk between RPTPs REFERENCE 2 (residues 1 to 700) AUTHORS Wabakken,T., Hauge,H., Funderud,S. and Aasheim,H.C. TITLE Characterization, expression and functional aspects of a novel protein tyrosine phosphatase epsilon isoform JOURNAL Scand. J. Immunol. 56 (3), 276-285 (2002) MEDLINE 22181756 REMARK GeneRIF: Characterization, expression and functional aspects of an alternative spliced isoform of protein tyrosine phosphatase epsilon REFERENCE 3 (residues 1 to 700) AUTHORS Wabakken,T., Hauge,H., Finne,E.F., Wiedlocha,A. and Aasheim,H. TITLE Expression of human protein tyrosine phosphatase epsilon in leucocytes: a potential ERK pathway-regulating phosphatase JOURNAL Scand. J. Immunol. 56 (2), 195-203 (2002) MEDLINE 22118122 REMARK GeneRIF: Transfection of cells with different PTPepsilon constructs and activator protein-1 reporter gene indicates that the catalytic activity of PTPepsilon is involved in the regulation of the mitogen-activated protein kinase cascade. REFERENCE 4 (residues 1 to 700) AUTHORS Tanuma,N., Nakamura,K., Shima,H. and Kikuchi,K. TITLE Protein-tyrosine phosphatase PTPepsilon C inhibits Jak-STAT signaling and differentiation induced by interleukin-6 and leukemia inhibitory factor in M1 leukemia cells JOURNAL J. Biol. Chem. 275 (36), 28216-28221 (2000) MEDLINE 20428741 REMARK functional study of the mouse homolog REFERENCE 5 (residues 1 to 700) AUTHORS Peretz,A., Gil-Henn,H., Sobko,A., Shinder,V., Attali,B. and Elson,A. TITLE Hypomyelination and increased activity of voltage-gated K(+) channels in mice lacking protein tyrosine phosphatase epsilon JOURNAL EMBO J. 19 (15), 4036-4045 (2000) MEDLINE 20380937 REMARK functional study of the mouse homolog REFERENCE 6 (residues 1 to 700) AUTHORS Toledano-Katchalski,H. and Elson,A. TITLE The transmembranal and cytoplasmic forms of protein tyrosine phosphatase epsilon physically associate with the adaptor molecule Grb2 JOURNAL Oncogene 18 (36), 5024-5031 (1999) MEDLINE 99422037 REMARK functional study of the mouse homolog REFERENCE 7 (residues 1 to 700) AUTHORS Elson,A. and Leder,P. TITLE Identification of a cytoplasmic, phorbol ester-inducible isoform of protein tyrosine phosphatase epsilon JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (26), 12235-12239 (1995) MEDLINE 96109240 REFERENCE 8 (residues 1 to 700) AUTHORS van den Maagdenberg,A.M., van den Hurk,H.H., Weghuis,D., Wieringa,B., Geurts van Kessel,A. and Hendriks,W.J. TITLE Assignment of the human protein tyrosine phosphatase epsilon (PTPRE) gene to chromosome 10q26 by fluorescence in situ hybridization JOURNAL Genomics 30 (1), 128-129 (1995) MEDLINE 96129319 REFERENCE 9 (residues 1 to 700) AUTHORS Krueger,N.X., Streuli,M. and Saito,H. TITLE Structural diversity and evolution of human receptor-like protein tyrosine phosphatases JOURNAL EMBO J. 9 (10), 3241-3252 (1990) MEDLINE 91006018 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X54134.1, AJ315969.1 and BI559814.1. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels. Transcript Variant: This variant (1) contains a different 5' end region that includes a part of the coding region, when compared to variant 2. It thus encodes a protein that has a distinct N-terminus, as compared to isoform 2. The encoded protein is a receptor type isoform of this PTP. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hPTPepsilon_D1 (NP_006495) PTPRE| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..279 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="10" /map="10q26" /vntifkey="269" Protein 1..279 /product="protein tyrosine phosphatase, receptor type, E isoform 1 precursor" /EC_number="3.1.3.48" /vntifkey="270" /note="protein tyrosine phosphatase, receptor type, epsilon; protein tyrosine phosphatase, receptor type, epsilon polypeptide; protein tyrosine phosphatase epsilon" Region 1..279 /product="protein tyrosine phosphatase, receptor type, E, isoform 1" /EC_number="3.1.3.48" /vntifkey="203" /label=Chain_1 Region 17..279 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 ehleeeirir saddckqfre efnslpsghi qgtfelanke enreknrypn ilpndhsrvi 61 lsqldgipcs dyinasyidg ykeknkfiaa qgpkqetvnd fwrmvweqks ativmltnlk 121 erkeekchqy wpdqgcwtyg nirvcvedcv vlvdytirkf ciqpqlpdgc kaprlvsqlh 181 ftswpdfgvp ftpigmlkfl kkvktlnpvh agpivvhcsa gvgrtgtfiv idammammha 241 eqkvdvfefv srirnqrpqm vqtdmqytfi yqalleyyl // LOCUS hPTPgamma_ 291 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, G precursor; protein tyrosine phosphatase, receptor type, gamma polypeptide; protein tyrosine phosphatase gamma; receptor-type protein phosphatase gamma; receptor tyrosine phosphatase gamma [Homo sapiens]. ACCESSION NP_002832 DBSOURCE REFSEQ: accession NM_002841.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 1445) AUTHORS Liu,S., Sugimoto,Y., Kulp,S.K., Jiang,J., Chang,H.L., Park,K.Y., Kashida,Y. and Lin,Y.C. TITLE Estrogenic down-regulation of protein tyrosine phosphatase gamma (PTP gamma) in human breast is associated with estrogen receptor alpha JOURNAL Anticancer Res. 22 (6C), 3917-3923 (2002) MEDLINE 22441179 REMARK GeneRIF: Estrogenic down-regulation of protein tyrosine phosphatase gamma (PTP gamma) in human breast is associated with estrogen receptor alpha. REFERENCE 2 (residues 1 to 1445) AUTHORS Liu,S., Kulp,S.K., Sugimoto,Y., Jiang,J., Chang,H.L. and Lin,Y.C. TITLE Involvement of breast epithelial-stromal interactions in the regulation of protein tyrosine phosphatase-gamma (PTPgamma) mRNA expression by estrogenically active agents JOURNAL Breast Cancer Res. Treat. 71 (1), 21-35 (2002) MEDLINE 21848634 REMARK GeneRIF: both estradiol-17beta and zeranol regulate PTPgamma expression in human breast; epithelial-stromal cell interaction is important in regulation of PTPgamma expression by estrogenically active agents REFERENCE 3 (residues 1 to 1445) AUTHORS Kastury,K., Ohta,M., Lasota,J., Moir,D., Dorman,T., LaForgia,S., Druck,T. and Huebner,K. TITLE Structure of the human receptor tyrosine phosphatase gamma gene (PTPRG) and relation to the familial RCC t(3;8) chromosome translocation JOURNAL Genomics 32 (2), 225-235 (1996) MEDLINE 96429999 REFERENCE 4 (residues 1 to 1445) AUTHORS Barnea,G., Silvennoinen,O., Shaanan,B., Honegger,A.M., Canoll,P.D., D'Eustachio,P., Morse,B., Levy,J.B., Laforgia,S., Huebner,K. et al. TITLE Identification of a carbonic anhydrase-like domain in the extracellular region of RPTP gamma defines a new subfamily of receptor tyrosine phosphatases JOURNAL Mol. Cell. Biol. 13 (3), 1497-1506 (1993) MEDLINE 93180796 REFERENCE 5 (residues 1 to 1445) AUTHORS LaForgia,S., Morse,B., Levy,J., Barnea,G., Cannizzaro,L.A., Li,F., Nowell,P.C., Boghosian-Sell,L., Glick,J., Weston,A. et al. TITLE Receptor protein-tyrosine phosphatase gamma is a candidate tumor suppressor gene at human chromosome region 3p21 JOURNAL Proc. Natl. Acad. Sci. U.S.A. 88 (11), 5036-5040 (1991) MEDLINE 91271326 REFERENCE 6 (residues 1 to 1445) AUTHORS Krueger,N.X., Streuli,M. and Saito,H. TITLE Structural diversity and evolution of human receptor-like protein tyrosine phosphatases JOURNAL EMBO J. 9 (10), 3241-3252 (1990) MEDLINE 91006018 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from L09247.1, AI872451.1 and U46089.1. On Feb 22, 2002 this sequence version replaced gi:11386169. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hPTPgamma_D1 (NP_002832) PTPRG| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..291 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="3" /map="3p21-p14" /vntifkey="269" Protein 1..291 /product="protein tyrosine phosphatase, receptor type, G precursor" /EC_number="3.1.3.48" /vntifkey="270" /note="protein tyrosine phosphatase, receptor type, gamma polypeptide; protein tyrosine phosphatase gamma; receptor-type protein phosphatase gamma; receptor tyrosine phosphatase gamma" Region 1..291 /product="protein tyrosine phosphatase, receptor type, G" /vntifkey="203" /label=Chain_1 Region 17..291 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_2 /note="PTPc" ORIGIN 1 kqfvkhigel ysnnqhgfse dfeevqrcta dmnitaehsn hpenkhknry inilaydhsr 61 vklrplpgkd skhsdyinan yvdgynkaka yiatqgplks tfedfwrmiw eqntgiivmi 121 tnlvekgrrk cdqywptens eeygniivtl kstkihacyt vrrfsirntk vkkgqkgnpk 181 grqnervviq yhytqwpdmg vpeyalpvlt fvrrssaarm petgpvlvhc sagvgrtgty 241 ividsmlqqi kdkstvnvlg flkhirtqrn ylvqteeqyi fihdalleai l // LOCUS hPTPH1_D1\ 276 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 3; protein tyrosin phosphatase H1; cytoskeletal-associated protein tyrosine phosphatase [Homo sapiens]. ACCESSION NP_002820 DBSOURCE REFSEQ: accession NM_002829.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 913) AUTHORS Zheng,Y., Schlondorff,J. and Blobel,C.P. TITLE Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1 JOURNAL J. Biol. Chem. 277 (45), 42463-42470 (2002) MEDLINE 22301977 REMARK GeneRIF: regulates TACE (tnf-alpha convertase} REFERENCE 2 (residues 1 to 913) AUTHORS Zhang,S.H., Liu,J., Kobayashi,R. and Tonks,N.K. TITLE Identification of the cell cycle regulator VCP (p97/CDC48) as a substrate of the band 4.1-related protein-tyrosine phosphatase PTPH1 JOURNAL J. Biol. Chem. 274 (25), 17806-17812 (1999) MEDLINE 99292748 REFERENCE 3 (residues 1 to 913) AUTHORS Zhang,S.H., Kobayashi,R., Graves,P.R., Piwnica-Worms,H. and Tonks,N.K. TITLE Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein JOURNAL J. Biol. Chem. 272 (43), 27281-27287 (1997) MEDLINE 98001710 REFERENCE 4 (residues 1 to 913) AUTHORS Ikuta,S., Itoh,F., Hinoda,Y., Toyota,M., Makiguchi,Y., Imai,K. and Yachi,A. TITLE Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma JOURNAL J. Gastroenterol. 29 (6), 727-732 (1994) MEDLINE 95179278 REFERENCE 5 (residues 1 to 913) AUTHORS Itoh,F., Ikuta,S., Hinoda,Y., Arimura,Y., Ohe,M., Adachi,M., Ariyama,T., Inazawa,J., Imai,K. and Yachi,A. TITLE Expression and chromosomal assignment of PTPH1 gene encoding a cytosolic protein tyrosine phosphatase homologous to cytoskeletal-associated proteins JOURNAL Int. J. Cancer 55 (6), 947-951 (1993) MEDLINE 94075060 REFERENCE 6 (residues 1 to 913) AUTHORS Arimura,Y., Hinoda,Y., Itoh,F., Takekawa,M., Tsujisaki,M., Adachi,M., Imai,K. and Yachi,A. TITLE cDNA cloning of new protein tyrosine phosphatases in the human colon JOURNAL Tumour Biol. 13 (3), 180-186 (1992) MEDLINE 92327504 REFERENCE 7 (residues 1 to 913) AUTHORS Yang,Q. and Tonks,N.K. TITLE Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin JOURNAL Proc. Natl. Acad. Sci. U.S.A. 88 (14), 5949-5953 (1991) MEDLINE 91296738 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M64572.1 and W15441.1. On Jan 10, 2002 this sequence version replaced gi:4506293. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hPTPH1_D1 (NP_002820) PTPN3| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..276 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="9" /map="9q31" /vntifkey="269" Protein 1..276 /product="protein tyrosine phosphatase, non-receptor type 3" /EC_number="3.1.3.48" /vntifkey="270" /note="protein tyrosin phosphatase H1; cytoskeletal-associated protein tyrosine phosphatase" Region 22..276 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 dtlegsmaql kkglesgtvl iqfeqlyrkk pglaitfakl pqnldknryk dvlpydttrv 61 llqgnedyin asyvnmeipa anlvnkyiat qgplphtcaq fwqvvwdqkl slivmlttlt 121 ergrtkchqy wpdppdvmnh ggfhiqcqse dctiayvsre mlvtntqtge ehtvthlqyv 181 awpdhgvpdd ssdflefvny vrslrvdsep llvhcsagig rtgvlvtmet amclternlp 241 iypldivrkm rdqrammvqt ssqykfvcea ilrvye // LOCUS hPTPkappa_ 274 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, K precursor; protein-tyrosine phosphatase, receptor type, kappa; protein-tyrosine phosphatase kappa; protein-tyrosine phosphatase kappa precursor [Homo sapiens]. ACCESSION NP_002835 DBSOURCE REFSEQ: accession NM_002844.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 1440) AUTHORS Yang,Y., Gil,M.C., Choi,E.Y., Park,S.H., Pyun,K.H. and Ha,H. TITLE Molecular cloning and chromosomal localization of a human gene homologous to the murine R-PTP-kappa, a receptor-type protein tyrosine phosphatase JOURNAL Gene 186 (1), 77-82 (1997) MEDLINE 97199372 REFERENCE 2 (residues 1 to 1440) AUTHORS Yang,Y., Gil,M., Byun,S.M., Choi,I., Pyun,K.H. and Ha,H. TITLE Transforming growth factor-beta1 inhibits human keratinocyte proliferation by upregulation of a receptor-type tyrosine phosphatase R-PTP-kappa gene expression JOURNAL Biochem. Biophys. Res. Commun. 228 (3), 807-812 (1996) MEDLINE 97096334 REFERENCE 3 (residues 1 to 1440) AUTHORS Fuchs,M., Muller,T., Lerch,M.M. and Ullrich,A. TITLE Association of human protein-tyrosine phosphatase kappa with members of the armadillo family JOURNAL J. Biol. Chem. 271 (28), 16712-16719 (1996) MEDLINE 96279245 REFERENCE 4 (residues 1 to 1440) AUTHORS Zondag,G.C., Koningstein,G.M., Jiang,Y.P., Sap,J., Moolenaar,W.H. and Gebbink,M.F. TITLE Homophilic interactions mediated by receptor tyrosine phosphatases mu and kappa. A critical role for the novel extracellular MAM domain JOURNAL J. Biol. Chem. 270 (24), 14247-14250 (1995) MEDLINE 95301498 REFERENCE 5 (residues 1 to 1440) AUTHORS Sap,J., Jiang,Y.P., Friedlander,D., Grumet,M. and Schlessinger,J. TITLE Receptor tyrosine phosphatase R-PTP-kappa mediates homophilic binding JOURNAL Mol. Cell. Biol. 14 (1), 1-9 (1994) MEDLINE 94088505 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from L77886.1 and BI755683.1. On Feb 22, 2002 this sequence version replaced gi:4506317. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hPTPkappa_D1 (NP_002835) PTPRK| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..274 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="6" /map="6q22.2-23.1" /vntifkey="269" Protein 1..274 /product="protein tyrosine phosphatase, receptor type, K precursor" /EC_number="3.1.3.48" /vntifkey="270" /note="protein-tyrosine phosphatase, receptor type, kappa; protein-tyrosine phosphatase kappa; protein-tyrosine phosphatase kappa precursor" Region 1..274 /product="protein tyrosine phosphatase, receptor type, K" /vntifkey="203" /label=Chain_1 Region 17..274 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_2 /note="PTPc" ORIGIN 1 adllqhinlm ktsdsygfke eyesffegqs aswdvakkdq nraknrygni iaydhsrvil 61 qpveddpssd yinanyidgy qrpshyiatq gpvhetvydf wrmiwqeqsa civmvtnlve 121 vgrvkcykyw pddtevygdf kvtcvemepl aeyvvrtftl errgyneire vkqfhftgwp 181 dhgvpyhatg llsfirrvkl snppsagpiv vhcsagagrt gcyividiml dmaeregvvd 241 iyncvkalrs rrinmvqtee qyifihdail eacl // LOCUS hPTPlamda_ 270 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, U isoform 3 precursor; protein tyrosine phosphatase J; protein tyrosine phosphatase receptor omicron [Homo sapiens]. ACCESSION NP_005695 DBSOURCE REFSEQ: accession NM_005704.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 1446) AUTHORS Yan,H.X., He,Y.Q., Dong,H., Zhang,P., Zeng,J.Z., Cao,H.F., Wu,M.C. and Wang,H.Y. TITLE Physical and functional interaction between receptor-like protein tyrosine phosphatase PCP-2 and beta-catenin JOURNAL Biochemistry 41 (52), 15854-15860 (2002) MEDLINE 22389441 REMARK GeneRIF: Expressed in a cell density-dependent fashion, PCP-2 interacts directly with its substrate beta-catenin, independent of the tyrosine phosphorylation state of beta-catenin. REFERENCE 2 (residues 1 to 1446) AUTHORS Wang,B., Kishihara,K., Zhang,D., Sakamoto,T. and Nomoto,K. TITLE Transcriptional regulation of a receptor protein tyrosine phosphatase gene hPTP-J by PKC-mediated signaling pathways in Jurkat and Molt-4 T lymphoma cells JOURNAL Biochim. Biophys. Acta 1450 (3), 331-340 (1999) MEDLINE 99326162 REFERENCE 3 (residues 1 to 1446) AUTHORS Avraham,S., London,R., Tulloch,G.A., Ellis,M., Fu,Y., Jiang,S., White,R.A., Painter,C., Steinberger,A.A. and Avraham,H. TITLE Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells JOURNAL Gene 204 (1-2), 5-16 (1997) MEDLINE 98094249 REFERENCE 4 (residues 1 to 1446) AUTHORS Wang,B., Kishihara,K., Zhang,D., Hara,H. and Nomoto,K. TITLE Molecular cloning and characterization of a novel human receptor protein tyrosine phosphatase gene, hPTP-J: down-regulation of gene expression by PMA and calcium ionophore in Jurkat T lymphoma cells JOURNAL Biochem. Biophys. Res. Commun. 231 (1), 77-81 (1997) MEDLINE 97223402 REFERENCE 5 (residues 1 to 1446) AUTHORS Crossland,S., Smith,P.D. and Crompton,M.R. TITLE Molecular cloning and characterization of PTP pi, a novel receptor-like protein-tyrosine phosphatase JOURNAL Biochem. J. 319 (Pt 1), 249-254 (1996) MEDLINE 97024447 REFERENCE 6 (residues 1 to 1446) AUTHORS Wang,H., Lian,Z., Lerch,M.M., Chen,Z., Xie,W. and Ullrich,A. TITLE Characterization of PCP-2, a novel receptor protein tyrosine phosphatase of the MAM domain family JOURNAL Oncogene 12 (12), 2555-2562 (1996) MEDLINE 96293401 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X97198.1 and X95712.1. On Mar 26, 2002 this sequence version replaced gi:5032003. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Three alternatively spliced transcript variants, which encode distinct proteins, have been reported. Transcript Variant: This variant (3) encodes the longest isoform (3). COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hPTPlamda_D1 (NP_005695) PTPRU| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..270 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="1" /map="1p35.3-p35.1" /vntifkey="269" Protein 1..270 /product="protein tyrosine phosphatase, receptor type, U isoform 3 precursor" /vntifkey="270" /note="protein tyrosine phosphatase J; protein tyrosine phosphatase receptor omicron" Region 1..270 /product="protein tyrosine phosphatase, receptor type, U, isoform 3" /vntifkey="203" /label=Chain_1 Region 17..270 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_2 /note="PTPc" ORIGIN 1 adllqhinqm ktaegygfkq eyesffegwd atkkkdkvkg srqepmpayd rhrvklhpml 61 gdpnadyina nyidgyhrsn hfiatqgpkp emvydfwrmv wqehcssivm itklvevgrv 121 kcsrywpeds dtygdikiml vktetlaeyv vrtfalerrg ysarhevrqf hftawpehgv 181 pyhatgllaf irrvkastpp dagpivihcs agtgrtgcyi vldvmldmae cegvvdiync 241 vktlcsrrvn miqteeqyif ihdaileacl // LOCUS hPTPmu_D1\ 274 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, M precursor; protein tyrosine phosphatase, receptor type, mu polypeptide; protein tyrosine phosphatase mu precursor [Homo sapiens]. ACCESSION NP_002836 DBSOURCE REFSEQ: accession NM_002845.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 1452) AUTHORS Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J. TITLE Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases JOURNAL J. Biol. Chem. 277 (49), 47263-47269 (2002) MEDLINE 22344739 REMARK GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are a common but specific mechanism that is likely to be regulated- domain2s and the wedge structures are crucial determinants of binding specificity, thus regulating cross-talk between RPTPs REFERENCE 2 (residues 1 to 1452) AUTHORS Mourton,T., Hellberg,C.B., Burden-Gulley,S.M., Hinman,J., Rhee,A. and Brady-Kalnay,S.M. TITLE The PTPmu protein-tyrosine phosphatase binds and recruits the scaffolding protein RACK1 to cell-cell contacts JOURNAL J. Biol. Chem. 276 (18), 14896-14901 (2001) MEDLINE 21226727 REFERENCE 3 (residues 1 to 1452) AUTHORS Feiken,E., van Etten,I., Gebbink,M.F., Moolenaar,W.H. and Zondag,G.C. TITLE Intramolecular interactions between the juxtamembrane domain and phosphatase domains of receptor protein-tyrosine phosphatase RPTPmu. Regulation of catalytic activity JOURNAL J. Biol. Chem. 275 (20), 15350-15356 (2000) MEDLINE 20270248 REFERENCE 4 (residues 1 to 1452) AUTHORS Brady-Kalnay,S.M. and Tonks,N.K. TITLE Identification of the homophilic binding site of the receptor protein tyrosine phosphatase PTP mu JOURNAL J. Biol. Chem. 269 (45), 28472-28477 (1994) MEDLINE 95050637 REFERENCE 5 (residues 1 to 1452) AUTHORS Suijkerbuijk,R.F., Gebbink,M.F., Moolenaar,W.H. and Geurts van Kessel,A. TITLE Fine mapping of the human receptor-like protein tyrosine phosphatase gene (PTPRM) to 18p11.2 by fluorescence in situ hybridization JOURNAL Cytogenet. Cell Genet. 64 (3-4), 245-246 (1993) MEDLINE 94007972 REFERENCE 6 (residues 1 to 1452) AUTHORS Brady-Kalnay,S.M., Flint,A.J. and Tonks,N.K. TITLE Homophilic binding of PTP mu, a receptor-type protein tyrosine phosphatase, can mediate cell-cell aggregation JOURNAL J. Cell Biol. 122 (4), 961-972 (1993) MEDLINE 93352709 REFERENCE 7 (residues 1 to 1452) AUTHORS Gebbink,M.F., van Etten,I., Hateboer,G., Suijkerbuijk,R., Beijersbergen,R.L., Geurts van Kessel,A. and Moolenaar,W.H. TITLE Cloning, expression and chromosomal localization of a new putative receptor-like protein tyrosine phosphatase JOURNAL FEBS Lett. 290 (1-2), 123-130 (1991) MEDLINE 92008644 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X58288.1 and AA281524.1. On Feb 22, 2002 this sequence version replaced gi:4506319. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hPTPmu_D1 (NP_002836) PTPRM| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..274 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="18" /map="18p11.2" /vntifkey="269" Protein 1..274 /product="protein tyrosine phosphatase, receptor type, M precursor" /EC_number="3.1.3.48" /vntifkey="270" /note="protein tyrosine phosphatase, receptor type, mu polypeptide; protein tyrosine phosphatase mu precursor" Region 1..274 /product="protein tyrosine phosphatase, receptor type, M" /vntifkey="203" /label=Chain_1 Region 17..274 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_2 /note="PTPc" ORIGIN 1 adllqhitqm kcaegygfke eyesffegqs apwdsakkde nrmknrygni iaydhsrvrl 61 qtiegdtnsd yingnyidgy hrpnhyiatq gpmqetiydf wrmvwhenta siimvtnlve 121 vgrvkcckyw pddteiykdi kvtlietell aeyvirtfav ekrgvheire irqfhftgwp 181 dhgvpyhatg llgfvrqvks ksppsagplv vhcsagagrt gcfividiml dmaeregvvd 241 iyncvrelrs rrvnmvqtee qyvfihdail eacl // LOCUS hPTPrho_D1 274 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, T isoform 1 precursor; receptor protein tyrosine phosphatase [Homo sapiens]. ACCESSION NP_573400 DBSOURCE REFSEQ: accession NM_133170.1 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 1463) AUTHORS Besco,J.A., Frostholm,A., Popesco,M.C., Burghes,A.H. and Rotter,A. TITLE Genomic organization and alternative splicing of the human and mouse RPTPrho genes JOURNAL BMC Genomics 2 (1), 1 (2001) REFERENCE 2 (residues 1 to 1463) AUTHORS McAndrew,P.E., Frostholm,A., White,R.A., Rotter,A. and Burghes,A.H. TITLE Identification and characterization of RPTP rho, a novel RPTP mu/kappa-like receptor protein tyrosine phosphatase whose expression is restricted to the central nervous system JOURNAL Brain Res. Mol. Brain Res. 56 (1-2), 9-21 (1998) MEDLINE 98267260 REFERENCE 3 (residues 1 to 1463) AUTHORS McAndrew,P.E., Frostholm,A., Evans,J.E., Zdilar,D., Goldowitz,D., Chiu,I.M., Burghes,A.H. and Rotter,A. TITLE Novel receptor protein tyrosine phosphatase (RPTPrho) and acidic fibroblast growth factor (FGF-1) transcripts delineate a rostrocaudal boundary in the granule cell layer of the murine cerebellar cortex JOURNAL J. Comp. Neurol. 391 (4), 444-455 (1998) MEDLINE 98146229 REFERENCE 4 (residues 1 to 1463) AUTHORS Hillier,L.D., Lennon,G., Becker,M., Bonaldo,M.F., Chiapelli,B., Chissoe,S., Dietrich,N., DuBuque,T., Favello,A., Gish,W., Hawkins,M., Hultman,M., Kucaba,T., Lacy,M., Le,M., Le,N., Mardis,E., Moore,B., Morris,M., Parsons,J., Prange,C., Rifkin,L., Rohlfing,T., Schellenberg,K., Marra,M. et al. TITLE Generation and analysis of 280,000 human expressed sequence tags JOURNAL Genome Res. 6 (9), 807-828 (1996) MEDLINE 97044478 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF043644.4 and R50970.1. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. Transcript Variant: This variant (1) contains an additional fragment within the coding region when compared to variant 2, and thus encodes a protein that contains an extra internal segment, as compared to isoform 2. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hPTPrho_D1 (NP_573400) PTPRT| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..274 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="20" /map="20q12-q13" /vntifkey="269" Protein 1..274 /product="protein tyrosine phosphatase, receptor type, T isoform 1 precursor" /vntifkey="270" /note="receptor protein tyrosine phosphatase" Region 1..274 /product="protein tyrosine phosphatase, receptor type, T, isoform 1" /vntifkey="203" /label=Chain_1 Region 17..274 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 adllqhitqm krgqgygfke eyealpegqt aswdtakede nrnknrygni isydhsrvrl 61 lvldgdphsd yinanyidgy hrprhyiatq gpmqetvkdf wrmiwqensa sivmvtnlve 121 vgrvkcvryw pddtevygdi kvtlietepl aeyvirtftv qkkgyheire lrlfhftswp 181 dhgvpcyatg llgfvrqvkf lnppeagpiv vhcsagagrt gcfiaidtml dmaenegvvd 241 ifncvrelra qrvnlvqtee qyvfvhdail eacl // LOCUS hPTPS31_D1 276 aa 17-MAY-2003 DEFINITION Translation of a fragment of delete. KEYWORDS TRANSLATED. SOURCE ORGANISM COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hPTPS31_D1 (AR073855) PTPGMC1| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| ORIGIN 1 ksflqhveel ctnnnlkfqe efselpkflq dlsstdadlp wnraknrfpn ikpynnnrvk 61 liadasvpgs dyinasyisg ylcpnefiat qgplpgtvgd fwrmvwetra ktlvmltqcf 121 ekgrirchqy wpednkpvtv fgdivitklm edvqidwtir dlkierhgdc mtvrqcnfta 181 wpehgvpens aplihfvklv rasrahdttp mivhcsagvg rtgvfialdh ltqhindhdf 241 vdiyglvael rsermcmvqn laqyiflhqc ildlls // LOCUS hPTPsigma_ 275 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, sigma isoform 1 precursor; protein tyrosine phosphatase PTPsigma [Homo sapiens]. ACCESSION NP_002841 DBSOURCE REFSEQ: accession NM_002850.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 1948) AUTHORS Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J. TITLE Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases JOURNAL J. Biol. Chem. 277 (49), 47263-47269 (2002) MEDLINE 22344739 REMARK GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are a common but specific mechanism that is likely to be regulated- domain2s and the wedge structures are crucial determinants of binding specificity, thus regulating cross-talk between RPTPs REFERENCE 2 (residues 1 to 1948) AUTHORS Wallace,M.J., Batt,J., Fladd,C.A., Henderson,J.T., Skarnes,W. and Rotin,D. TITLE Neuronal defects and posterior pituitary hypoplasia in mice lacking the receptor tyrosine phosphatase PTPsigma JOURNAL Nat. Genet. 21 (3), 334-338 (1999) MEDLINE 99178277 REMARK functional study of the mouse homolog REFERENCE 3 (residues 1 to 1948) AUTHORS Elchebly,M., Wagner,J., Kennedy,T.E., Lanctot,C., Michaliszyn,E., Itie,A., Drouin,J. and Tremblay,M.L. TITLE Neuroendocrine dysplasia in mice lacking protein tyrosine phosphatase sigma JOURNAL Nat. Genet. 21 (3), 330-333 (1999) MEDLINE 99178276 REMARK functional study of the mouse homolog REFERENCE 4 (residues 1 to 1948) AUTHORS Haworth,K., Shu,K.K., Stokes,A., Morris,R. and Stoker,A. TITLE The expression of receptor tyrosine phosphatases is responsive to sciatic nerve crush JOURNAL Mol. Cell. Neurosci. 12 (3), 93-104 (1998) MEDLINE 99009170 REMARK functional study of the rat homolog REFERENCE 5 (residues 1 to 1948) AUTHORS Wagner,J., Gordon,L.A., Heng,H.H., Tremblay,M.L. and Olsen,A.S. TITLE Physical mapping of receptor type protein tyrosine phosphatase sigma (PTPRS) to human chromosome 19p13.3 JOURNAL Genomics 38 (1), 76-78 (1996) MEDLINE 97124849 REFERENCE 6 (residues 1 to 1948) AUTHORS Endo,N., Rutledge,S.J., Opas,E.E., Vogel,R., Rodan,G.A. and Schmidt,A. TITLE Human protein tyrosine phosphatase-sigma: alternative splicing and inhibition by bisphosphonates JOURNAL J. Bone Miner. Res. 11 (4), 535-543 (1996) MEDLINE 96255038 REFERENCE 7 (residues 1 to 1948) AUTHORS Pulido,R., Serra-Pages,C., Tang,M. and Streuli,M. TITLE The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1 JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (25), 11686-11690 (1995) MEDLINE 96102179 REFERENCE 8 (residues 1 to 1948) AUTHORS Adachi,M., Sekiya,M., Arimura,Y., Takekawa,M., Itoh,F., Hinoda,Y., Imai,K. and Yachi,A. TITLE Protein-tyrosine phosphatase expression in pre-B cell NALM-6 JOURNAL Cancer Res. 52 (3), 737-740 (1992) MEDLINE 92119637 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U35234.1 and BI461316.1. On Mar 26, 2002 this sequence version replaced gi:4506327. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. Transcript Variant: This variant (1) encodes the longest isoform (1). COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hPTPsigma_D1 (NP_002841) PTPRS| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..275 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="19" /map="19p13.3" /vntifkey="269" Protein 1..275 /product="protein tyrosine phosphatase, receptor type, sigma isoform 1 precursor" /vntifkey="270" /note="protein tyrosine phosphatase PTPsigma" Region 1..275 /product="protein tyrosine phosphatase, receptor type, sigma, isoform 1" /vntifkey="203" /label=Chain_1 Region 17..274 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_4 /note="PTPc" ORIGIN 1 admaehterl kandslklsq eyesidpgqq ftwehsnlev nkpknryanv iaydhsrvil 61 qpiegimgsd yinanyvdgy rrqnayiatq gplpetfgdf wrmvweqrsa tivmmtrlee 121 ksrikcdqyw pnrgtetygf iqvtlldtie latfcvrtfs lhkngssekr evrqfqftaw 181 pdhgvpeypt pflaflrrvk tcnppdagpi vvhcsagvgr tgcfividam lerikpektv 241 dvyghvtlmr sqrnymvqte dqysfiheal leavg // LOCUS hPTPTyp_D1 274 aa 17-MAY-2003 DEFINITION Translation of a fragment of hPTPTyp (AL050040). KEYWORDS TRANSLATED. SOURCE ORGANISM COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hPTPTyp_D1 (AL050040) PTPN20| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| ORIGIN 1 taikdclkil eektaaydim qefmalelkn lpgefysgnq psnreknryr dilpydstrv 61 plgkskdyin asyirivncg eeyfyiatqg pllstiddfw qmvlennsnv iamitremeg 121 giikcyhywp islkkplelk hfrvflenyq ilqyfiirmf qvvekstgts hsvkqlqftk 181 wpdhgtpasa dsfikyirya rkshltgpmv vhcsagigrt gvflcvdvvf caivkdcsfn 241 imdivaqmre qrsgmvqtke qyhfcydivl evlr // LOCUS hPTPzeta_D 293 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor-type, Z polypeptide 1; protein tyrosine phosphatase, receptor-type, zeta polypeptide 1; receptor-type tyrosine phosphatase beta/zeta [Homo sapiens]. ACCESSION NP_002842 DBSOURCE REFSEQ: accession NM_002851.1 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 2314) AUTHORS Harroch,S., Furtado,G.C., Brueck,W., Rosenbluth,J., Lafaille,J., Chao,M., Buxbaum,J.D. and Schlessinger,J. TITLE A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions JOURNAL Nat. Genet. 32 (3), 411-414 (2002) MEDLINE 22297719 REMARK GeneRIF: PTPRZ1 has a role in oligodendrocyte survival and in recovery from demyelinating disease REFERENCE 2 (residues 1 to 2314) AUTHORS Thomaidou,D., Coquillat,D., Meintanis,S., Noda,M., Rougon,G. and Matsas,R. TITLE Soluble forms of NCAM and F3 neuronal cell adhesion molecules promote Schwann cell migration: identification of protein tyrosine phosphatases zeta/beta as the putative F3 receptors on Schwann cells JOURNAL J. Neurochem. 78 (4), 767-778 (2001) MEDLINE 21412137 REFERENCE 3 (residues 1 to 2314) AUTHORS Kawachi,H., Fujikawa,A., Maeda,N. and Noda,M. TITLE Identification of GIT1/Cat-1 as a substrate molecule of protein tyrosine phosphatase zeta /beta by the yeast substrate-trapping system JOURNAL Proc. Natl. Acad. Sci. U.S.A. 98 (12), 6593-6598 (2001) MEDLINE 21287250 REFERENCE 4 (residues 1 to 2314) AUTHORS Meng,K., Rodriguez-Pena,A., Dimitrov,T., Chen,W., Yamin,M., Noda,M. and Deuel,T.F. TITLE Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta JOURNAL Proc. Natl. Acad. Sci. U.S.A. 97 (6), 2603-2608 (2000) MEDLINE 20183934 REFERENCE 5 (residues 1 to 2314) AUTHORS Kawachi,H., Tamura,H., Watakabe,I., Shintani,T., Maeda,N. and Noda,M. TITLE Protein tyrosine phosphatase zeta/RPTPbeta interacts with PSD-95/SAP90 family JOURNAL Brain Res. Mol. Brain Res. 72 (1), 47-54 (1999) MEDLINE 99453345 REFERENCE 6 (residues 1 to 2314) AUTHORS Onyango,P., Lubyova,B., Gardellin,P., Kurzbauer,R. and Weith,A. TITLE Molecular cloning and expression analysis of five novel genes in chromosome 1p36 JOURNAL Genomics 50 (2), 187-198 (1998) MEDLINE 98317532 REFERENCE 7 (residues 1 to 2314) AUTHORS Ariyama,T., Hasegawa,K., Inazawa,J., Mizuno,K., Ogimoto,M., Katagiri,T. and Yakura,H. TITLE Assignment of the human protein tyrosine phosphatase, receptor-type, zeta (PTPRZ) gene to chromosome band 7q31.3 JOURNAL Cytogenet. Cell Genet. 70 (1-2), 52-54 (1995) MEDLINE 95254878 REFERENCE 8 (residues 1 to 2314) AUTHORS Levy,J.B., Canoll,P.D., Silvennoinen,O., Barnea,G., Morse,B., Honegger,A.M., Huang,J.T., Cannizzaro,L.A., Park,S.H., Druck,T. et al. TITLE The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system JOURNAL J. Biol. Chem. 268 (14), 10573-10581 (1993) MEDLINE 93252948 REFERENCE 9 (residues 1 to 2314) AUTHORS Krueger,N.X. and Saito,H. TITLE A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (16), 7417-7421 (1992) MEDLINE 92366472 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M93426.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hPTPzeta_D1 (NP_002842) PTPRZ1| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..293 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="7" /map="7q31.3" /tissue_type="brain" /dev_stage="fetus" /tissue_lib="lambda gt10 and gt11" /vntifkey="269" Protein 1..293 /product="protein tyrosine phosphatase, receptor-type, Z polypeptide 1" /vntifkey="270" /note="protein tyrosine phosphatase, receptor-type, zeta polypeptide 1; receptor-type tyrosine phosphatase beta/zeta" Region 15..293 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_2 /note="PTPc" ORIGIN 1 khfpkhvadl hassgfteef etlkefyqev qsctvdlgit adssnhpdnk hknryiniva 61 ydhsrvklaq laekdgkltd yinanyvdgy nrpkayiaaq gplkstaedf wrmiwehnve 121 vivmitnlve kgrrkcdqyw padgseeygn flvtqksvqv layytvrnft lrntkikkgs 181 qkgrpsgrvv tqyhytqwpd mgvpeyslpv ltfvrkaaya krhavgpvvv hcsagvgrtg 241 tyivldsmlq qiqhegtvni fgflkhirsq rnylvqteeq yvfihdtlve ail // LOCUS hSAP1_D1\( 279 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, H precursor [Homo sapiens]. ACCESSION NP_002833 DBSOURCE REFSEQ: accession NM_002842.1 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 1118) AUTHORS Takada,T., Noguchi,T., Inagaki,K., Hosooka,T., Fukunaga,K., Yamao,T., Ogawa,W., Matozaki,T. and Kasuga,M. TITLE Induction of apoptosis by stomach cancer-associated protein-tyrosine phosphatase-1 JOURNAL J. Biol. Chem. 277 (37), 34359-34366 (2002) MEDLINE 22206505 REMARK GeneRIF: SAP-1 induces apoptotic cell death by inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. REFERENCE 2 (residues 1 to 1118) AUTHORS Marneros,A.G., Mehenni,H., Reichenberger,E., Antonarakis,S.E., Krieg,T. and Olsen,B.R. TITLE Gene for the human transmembrane-type protein tyrosine phosphatase H (PTPRH): genomic structure, fine-mapping and its exclusion as a candidate for Peutz-Jeghers syndrome JOURNAL Cytogenet. Cell Genet. 92 (3-4), 213-216 (2001) MEDLINE 21328879 REFERENCE 3 (residues 1 to 1118) AUTHORS Matozaki,T., Suzuki,T., Uchida,T., Inazawa,J., Ariyama,T., Matsuda,K., Horita,K., Noguchi,H., Mizuno,H., Sakamoto,C. et al. TITLE Molecular cloning of a human transmembrane-type protein tyrosine phosphatase and its expression in gastrointestinal cancers JOURNAL J. Biol. Chem. 269 (3), 2075-2081 (1994) MEDLINE 94124561 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from D15049.1. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hSAP1_D1 (NP_002833) PTPRH| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..279 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="19" /map="19q13.4" /vntifkey="269" Protein 1..279 /product="protein tyrosine phosphatase, receptor type, H precursor" /EC_number="3.1.3.48" /vntifkey="270" Region 1..279 /product="protein tyrosine phosphatase, receptor type, H" /vntifkey="203" /label=Chain_1 Region 17..274 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 edfadhvrkn erdsncgfad eyqqlslvgh sqsqmvasas ennaknryrn vlpydwsrvp 61 lkpiheepgs dyinasfmpg lwspqefiat qgplpqtvgd fwrlvweqqs htlvmltncm 121 eagrvkcehy wpldsqpcth ghlrvtlvge evmenwtvre llllqveeqk tlsvrqfhyq 181 awpdhgvpss pdtllafwrm lrqwldqtme ggppivhcsa gvgrtgtlia ldvllrqlqs 241 egllgpfsfv rkmresrplm vqteaqyvfl hqcicgssn // LOCUS hSHP1_D1\( 297 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 6 isoform 1; protein-tyrosine phosphatase 1C; hematopoietic cell phophatase; hematopoietic cell protein-tyrosine phosphatase; 70 kda SHP-1L protein [Homo sapiens]. ACCESSION NP_002822 DBSOURCE REFSEQ: accession NM_002831.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 595) AUTHORS Hanson,E.M., Dickensheets,H., Qu,C.K., Donnelly,R.P. and Keegan,A.D. TITLE Regulation of the dephosphorylation of Stat6. Participation of Tyr-713 in the interleukin-4 receptor alpha, the tyrosine phosphatase SHP-1, and the proteasome JOURNAL J. Biol. Chem. 278 (6), 3903-3911 (2003) MEDLINE 22450671 REMARK GeneRIF: participation in regulation of Stat6 dephosphorylation REFERENCE 2 (residues 1 to 595) AUTHORS Oka,T., Ouchida,M., Koyama,M., Ogama,Y., Takada,S., Nakatani,Y., Tanaka,T., Yoshino,T., Hayashi,K., Ohara,N., Kondo,E., Takahashi,K., Tsuchiyama,J., Tanimoto,M., Shimizu,K. and Akagi,T. TITLE Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas JOURNAL Cancer Res. 62 (22), 6390-6394 (2002) MEDLINE 22325693 REMARK GeneRIF: Functional loss of SHP1 is associated with the pathogenesis of leukemias/lymphomas. REFERENCE 3 (residues 1 to 595) AUTHORS Leon,F., Cespon,C., Franco,A., Lombardia,M., Roldan,E., Escribano,L., Harto,A., Gonzalez-Porque,P. and Roy,G. TITLE SHP-1 expression in peripheral T cells from patients with Sezary syndrome and in the T cell line HUT-78: implications in JAK3-mediated signaling JOURNAL Leukemia 16 (8), 1470-1477 (2002) MEDLINE 22140504 REMARK GeneRIF: In the T cell line HUT-78, JAK3 was found to be highly phosphorylated. These results suggest that SHP-1 might be involved in maintaining the IL-2R/JAK3 signaling pathway under control and point towards a role of SHP-1 in the pathogenesis of the disease. REFERENCE 4 (residues 1 to 595) AUTHORS Nikolova,M., Musette,P., Bagot,M., Boumsell,L. and Bensussan,A. TITLE Engagement of ILT2/CD85j in Sezary syndrome cells inhibits their CD3/TCR signaling JOURNAL Blood 100 (3), 1019-1025 (2002) MEDLINE 22122461 REMARK GeneRIF: ILT2 triggering on cutaneous T-cell lymphoma (CTCL) cells leads to the recruitment of SHP-1 and to the specific inhibition of CTCL malignant cell proliferation in S##zary syndrome induced by CD3/T-cell receptor. (TCR) stimulation. REFERENCE 5 (residues 1 to 595) AUTHORS Angata,T., Kerr,S.C., Greaves,D.R., Varki,N.M., Crocker,P.R. and Varki,A. TITLE Cloning and characterization of human Siglec-11. A recently evolved signaling that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia JOURNAL J. Biol. Chem. 277 (27), 24466-24474 (2002) MEDLINE 22086217 REMARK GeneRIF: interacts with siglec-11 REFERENCE 6 (residues 1 to 595) AUTHORS Vyas,Y.M., Maniar,H. and Dupont,B. TITLE Cutting edge: differential segregation of the SRC homology 2-containing protein tyrosine phosphatase-1 within the early NK cell immune synapse distinguishes noncytolytic from cytolytic interactions JOURNAL J. Immunol. 168 (7), 3150-3154 (2002) MEDLINE 21904490 REMARK GeneRIF: SHP-1 is recruited to the NK cell immune synapse within 1 min in both cytolytic and noncytolytic conjugates, allowing clear distinction between noncytolytic and cytolytic interactions at this early time. REFERENCE 7 (residues 1 to 595) AUTHORS Kurita-Taniguchi,M., Hazeki,K., Murabayashi,N., Fukui,A., Tsuji,S., Matsumoto,M., Toyoshima,K. and Seya,T. TITLE Molecular assembly of CD46 with CD9, alpha3-beta1 integrin and protein tyrosine phosphatase SHP-1 in human macrophages through differentiation by GM-CSF JOURNAL Mol. Immunol. 38 (9), 689-700 (2002) MEDLINE 21848359 REMARK GeneRIF: peripheral blood monocytes treated for 5--8 days with GM-CSF (i.e. mature Mphi) acquired the capacity to assemble tyrosine phosphatase SHP-1 with CD9, alpha3-beta1 integrin and their CD46. REFERENCE 8 (residues 1 to 595) AUTHORS Blasioli,J. and Goodnow,C.C. TITLE Lyn/CD22/SHP-1 and their importance in autoimmunity JOURNAL Curr. Dir. Autoimmun. 5, 151-160 (2002) MEDLINE 21685428 REMARK GeneRIF: The Lyn/CD22/SHP-1 pathway is important in autoimmunity. Naive and tolerant B-cells differ in their calcium signaling in response to antigenic stimulation. REFERENCE 9 (residues 1 to 595) AUTHORS Jin,Y.J., Yu,C.L. and Burakoff,S.J. TITLE Human 70-kDa SHP-1L differs from 68-kDa SHP-1 in its C-terminal structure and catalytic activity JOURNAL J. Biol. Chem. 274 (40), 28301-28307 (1999) MEDLINE 99428497 REFERENCE 10 (residues 1 to 595) AUTHORS Bousquet,C., Delesque,N., Lopez,F., Saint-Laurent,N., Esteve,J.P., Bedecs,K., Buscail,L., Vaysse,N. and Susini,C. TITLE sst2 somatostatin receptor mediates negative regulation of insulin receptor signaling through the tyrosine phosphatase SHP-1 JOURNAL J. Biol. Chem. 273 (12), 7099-7106 (1998) MEDLINE 98175983 REFERENCE 11 (residues 1 to 595) AUTHORS Blery,M., Kubagawa,H., Chen,C.C., Vely,F., Cooper,M.D. and Vivier,E. TITLE The paired Ig-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1 JOURNAL Proc. Natl. Acad. Sci. U.S.A. 95 (5), 2446-2451 (1998) MEDLINE 98151532 REFERENCE 12 (residues 1 to 595) AUTHORS Ono,M., Okada,H., Bolland,S., Yanagi,S., Kurosaki,T. and Ravetch,J.V. TITLE Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling JOURNAL Cell 90 (2), 293-301 (1997) MEDLINE 97386454 REFERENCE 13 (residues 1 to 595) AUTHORS Li,R.Y., Gaits,F., Ragab,A., Ragab-Thomas,J.M. and Chap,H. TITLE Tyrosine phosphorylation of an SH2-containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via a pertussis toxin-sensitive heterotrimeric G-protein JOURNAL EMBO J. 14 (11), 2519-2526 (1995) MEDLINE 95300784 REFERENCE 14 (residues 1 to 595) AUTHORS Banville,D., Stocco,R. and Shen,S.H. TITLE Human protein tyrosine phosphatase 1C (PTPN6) gene structure: alternate promoter usage and exon skipping generate multiple transcripts JOURNAL Genomics 27 (1), 165-173 (1995) MEDLINE 95394454 REFERENCE 15 (residues 1 to 595) AUTHORS Plutzky,J., Neel,B.G., Rosenberg,R.D., Eddy,R.L., Byers,M.G., Jani-Sait,S. and Shows,T.B. TITLE Chromosomal localization of an SH2-containing tyrosine phosphatase (PTPN6) JOURNAL Genomics 13 (3), 869-872 (1992) MEDLINE 92347896 REFERENCE 16 (residues 1 to 595) AUTHORS Plutzky,J., Neel,B.G. and Rosenberg,R.D. TITLE Isolation of a src homology 2-containing tyrosine phosphatase JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (3), 1123-1127 (1992) MEDLINE 92141214 REFERENCE 17 (residues 1 to 595) AUTHORS Yi,T.L., Cleveland,J.L. and Ihle,J.N. TITLE Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13 JOURNAL Mol. Cell. Biol. 12 (2), 836-846 (1992) MEDLINE 92123209 REFERENCE 18 (residues 1 to 595) AUTHORS Shen,S.H., Bastien,L., Posner,B.I. and Chretien,P. TITLE A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases JOURNAL Nature 352 (6337), 736-739 (1991) MEDLINE 91343005 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M77273.1, BC002523.1 and U15536.1. On Jan 10, 2002 this sequence version replaced gi:4506297. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Three alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. Transcript Variant: This variant (1) lacks an internal fragment within the coding region, which leads to a translation frame change when compared to variant 3. It encodes a protein that has an identical N-terminus and a different C-terminus, as compared to isoform 3. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hSHP1_D1 (NP_002822) PTPN6| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..297 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="12" /map="12p13" /vntifkey="269" Protein 1..297 /product="protein tyrosine phosphatase, non-receptor type 6 isoform 1" /EC_number="3.1.3.48" /vntifkey="270" /note="protein-tyrosine phosphatase 1C; hematopoietic cell phophatase; hematopoietic cell protein-tyrosine phosphatase; 70 kda SHP-1L protein" Region 23..297 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 adienrvlel nkkqesedta kagfweefes lqkqevknlh qrlegqrpen kgknryknil 61 pfdhsrvilq grdsnipgsd yinanyiknq llgpdenakt yiasqgclea tvndfwqmaw 121 qensrvivmt trevekgrnk cvpywpevgm qraygpysvt ncgehdttey klrtlqvspl 181 dngdlireiw hyqylswpdh gvpsepggvl sfldqinqrq eslphagpii vhcsagigrt 241 gtiividmlm enistkgldc didiqktiqm vraqrsgmvq teaqykfiyv aiaqfie // LOCUS hSHP2_D1\( 300 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 11 isoform 1; protein-tyrosine phosphatase 2C; Noonan syndrome 1; protein tyrosine phosphatase, non-receptor type 11 [Homo sapiens]. ACCESSION NP_002825 DBSOURCE REFSEQ: accession NM_002834.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 593) AUTHORS Yamazaki,S., Yamakawa,A., Ito,Y., Ohtani,M., Higashi,H., Hatakeyama,M. and Azuma,T. TITLE The CagA protein of Helicobacter pylori is translocated into epithelial cells and binds to SHP-2 in human gastric mucosa JOURNAL J. Infect. Dis. 187 (2), 334-337 (2003) MEDLINE 22439942 REMARK GeneRIF: The CagA protein of Helicobacter pylori is translocated into epithelial cells and binds to SHP-2 in human gastric mucosa REFERENCE 2 (residues 1 to 593) AUTHORS Lehmann,U., Schmitz,J., Weissenbach,M., Sobota,R.M., Hortner,M., Friederichs,K., Behrmann,I., Tsiaris,W., Sasaki,A., Schneider-Mergener,J., Yoshimura,A., Neel,B.G., Heinrich,P.C. and Schaper,F. TITLE SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130 JOURNAL J. Biol. Chem. 278 (1), 661-671 (2003) MEDLINE 22393451 REMARK GeneRIF: These data suggest, that there are two, largely distinct modes of negative regulation of gp130 activity, despite the fact that both SOCS3 and SHP2 are recruited to the same site within gp130. REFERENCE 3 (residues 1 to 593) AUTHORS Wu,T.R., Hong,Y.K., Wang,X.D., Ling,M.Y., Dragoi,A.M., Chung,A.S., Campbell,A.G., Han,Z.Y., Feng,G.S. and Chin,Y.E. TITLE SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei JOURNAL J. Biol. Chem. 277 (49), 47572-47580 (2002) MEDLINE 22344627 REMARK GeneRIF: SHP-2 is a dual-specificity protein phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues and plays an important role in modulating STAT function in gene regulation REFERENCE 4 (residues 1 to 593) AUTHORS Maile,L.A. and Clemmons,D.R. TITLE The alphaVbeta3 integrin regulates insulin-like growth factor I (IGF-I) receptor phosphorylation by altering the rate of recruitment of the Src-homology 2-containing phosphotyrosine phosphatase-2 to the activated IGF-I receptor JOURNAL Endocrinology 143 (11), 4259-4264 (2002) MEDLINE 22286240 REMARK GeneRIF: activation state of alphaVbeta3 integrin is an important regulator of the duration of insulin-like growth factor I receptor phosphorylation and this regulation is mediated through changes in the subcellular localization of SHP-2 REFERENCE 5 (residues 1 to 593) AUTHORS Ion,A., Tartaglia,M., Song,X., Kalidas,K., van der Burgt,I., Shaw,A.C., Ming,J.E., Zampino,G., Zackai,E.H., Dean,J.C., Somer,M., Parenti,G., Crosby,A.H., Patton,M.A., Gelb,B.D. and Jeffery,S. TITLE Absence of PTPN11 mutations in 28 cases of cardiofaciocutaneous (CFC) syndrome JOURNAL Hum. Genet. 111 (4-5), 421-427 (2002) MEDLINE 22271640 REMARK GeneRIF: absence of mutation in cases of cardiofaciocutaneous syndrome REFERENCE 6 (residues 1 to 593) AUTHORS Cai,T., Nishida,K., Hirano,T. and Khavari,P.A. TITLE Gab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation JOURNAL J. Cell Biol. 159 (1), 103-112 (2002) MEDLINE 22267353 REMARK GeneRIF: Results indicate that Gab1 and SHP-2 promote the undifferentiated epidermal cell state by facilitating Ras/MAPK signaling. REFERENCE 7 (residues 1 to 593) AUTHORS Maheshwari,M., Belmont,J., Fernbach,S., Ho,T., Molinari,L., Yakub,I., Yu,F., Combes,A., Towbin,J., Craigen,W.J. and Gibbs,R. TITLE PTPN11 mutations in Noonan syndrome type I: detection of recurrent mutations in exons 3 and 13 JOURNAL Hum. Mutat. 20 (4), 298-304 (2002) MEDLINE 22236043 REMARK GeneRIF: Mutations in PTPN11/SHP2 underlie a common form of Noonan syndrome and confirm that the disease exhibits both allelic and locus heterogeneity. REFERENCE 8 (residues 1 to 593) AUTHORS Legius,E., Schrander-Stumpel,C., Schollen,E., Pulles-Heintzberger,C., Gewillig,M. and Fryns,J.P. TITLE PTPN11 mutations in LEOPARD syndrome JOURNAL J. Med. Genet. 39 (8), 571-574 (2002) MEDLINE 22151430 REMARK GeneRIF: Some PTPN11 mutations (e.g., Y279C) are associated with both the Noonan syndrome phenotype and with skin pigmentation anomalies, such as multiple lentigines or caf## au lait spots (LEOPARD syndrome). REFERENCE 9 (residues 1 to 593) AUTHORS Kosaki,K., Suzuki,T., Muroya,K., Hasegawa,T., Sato,S., Matsuo,N., Kosaki,R., Nagai,T., Hasegawa,Y. and Ogata,T. TITLE PTPN11 (protein-tyrosine phosphatase, nonreceptor-type 11) mutations in seven Japanese patients with Noonan syndrome JOURNAL J. Clin. Endocrinol. Metab. 87 (8), 3529-3533 (2002) MEDLINE 22151235 REMARK GeneRIF: PTPN11 mutations are responsible for Noonan syndrome in a substantial fraction of patients and that relatively infrequent features of Noonan syndrome, such as sensory deafness and bleeding diathesis, can also result from mutations of PTPN11. REFERENCE 10 (residues 1 to 593) AUTHORS Angata,T., Kerr,S.C., Greaves,D.R., Varki,N.M., Crocker,P.R. and Varki,A. TITLE Cloning and characterization of human Siglec-11. A recently evolved signaling that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia JOURNAL J. Biol. Chem. 277 (27), 24466-24474 (2002) MEDLINE 22086217 REMARK GeneRIF: interacts with siglec-11 REFERENCE 11 (residues 1 to 593) AUTHORS Bordin,L., Brunati,A.M., Donella-Deana,A., Baggio,B., Toninello,A. and Clari,G. TITLE Band 3 is an anchor protein and a target for SHP-2 tyrosine phosphatase in human erythrocytes JOURNAL Blood 100 (1), 276-282 (2002) MEDLINE 22065093 REMARK GeneRIF: Band 3 is an anchor protein for and a target for SHP-2 tyrosine phosphatase in human erythrocytes. REFERENCE 12 (residues 1 to 593) AUTHORS Tartaglia,M., Kalidas,K., Shaw,A., Song,X., Musat,D.L., van der Burgt,I., Brunner,H.G., Bertola,D.R., Crosby,A., Ion,A., Kucherlapati,R.S., Jeffery,S., Patton,M.A. and Gelb,B.D. TITLE PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity JOURNAL Am. J. Hum. Genet. 70 (6), 1555-1563 (2002) MEDLINE 21987645 REMARK GeneRIF: PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity. REFERENCE 13 (residues 1 to 593) AUTHORS Lacalle,R.A., Mira,E., Gomez-Mouton,C., Jimenez-Baranda,S., Martinez-A,C. and Manes,S. TITLE Specific SHP-2 partitioning in raft domains triggers integrin-mediated signaling via Rho activation JOURNAL J. Cell Biol. 157 (2), 277-289 (2002) MEDLINE 21953171 REMARK GeneRIF: Specific SHP-2 partitioning in raft domains triggers integrin-mediated signaling via Rho activation REFERENCE 14 (residues 1 to 593) AUTHORS Ekman,S., Kallin,A., Engstrom,U., Heldin,C.H. and Ronnstrand,L. TITLE SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF beta-receptor JOURNAL Oncogene 21 (12), 1870-1875 (2002) MEDLINE 21906255 REMARK GeneRIF: SHP-2 modulates phosphorylation of PDGF receptors, thereby controls RasGTP recruitment and Ras/MAP kinase signaling in the heterodimeric configuration of the PDGF receptors REFERENCE 15 (residues 1 to 593) AUTHORS Higashi,H., Tsutsumi,R., Muto,S., Sugiyama,T., Azuma,T., Asaka,M. and Hatakeyama,M. TITLE SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein JOURNAL Science 295 (5555), 683-686 (2002) MEDLINE 21669283 REMARK GeneRIF: upon translocation, CagA perturbs cellular functions by deregulating SHP-2 REFERENCE 16 (residues 1 to 593) AUTHORS Fukunaga,K., Noguchi,T., Takeda,H., Matozaki,T., Hayashi,Y., Itoh,H. and Kasuga,M. TITLE Requirement for protein-tyrosine phosphatase SHP-2 in insulin-induced activation of c-Jun NH(2)-terminal kinase JOURNAL J. Biol. Chem. 275 (7), 5208-5213 (2000) MEDLINE 20138272 REFERENCE 17 (residues 1 to 593) AUTHORS Yu,C.L., Jin,Y.J. and Burakoff,S.J. TITLE Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation JOURNAL J. Biol. Chem. 275 (1), 599-604 (2000) MEDLINE 20085083 REFERENCE 18 (residues 1 to 593) AUTHORS Li,C. and Friedman,J.M. TITLE Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction JOURNAL Proc. Natl. Acad. Sci. U.S.A. 96 (17), 9677-9682 (1999) MEDLINE 99380578 REFERENCE 19 (residues 1 to 593) AUTHORS Manes,S., Mira,E., Gomez-Mouton,C., Zhao,Z.J., Lacalle,R.A. and Martinez-A,C. TITLE Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility JOURNAL Mol. Cell. Biol. 19 (4), 3125-3135 (1999) MEDLINE 99182500 REFERENCE 20 (residues 1 to 593) AUTHORS Takada,T., Matozaki,T., Takeda,H., Fukunaga,K., Noguchi,T., Fujioka,Y., Okazaki,I., Tsuda,M., Yamao,T., Ochi,F. and Kasuga,M. TITLE Roles of the complex formation of SHPS-1 with SHP-2 in insulin-stimulated mitogen-activated protein kinase activation JOURNAL J. Biol. Chem. 273 (15), 9234-9242 (1998) MEDLINE 98204923 REFERENCE 21 (residues 1 to 593) AUTHORS Jamieson,C.R., van der Burgt,I., Brady,A.F., van Reen,M., Elsawi,M.M., Hol,F., Jeffery,S., Patton,M.A. and Mariman,E. TITLE Mapping a gene for Noonan syndrome to the long arm of chromosome 12 JOURNAL Nat. Genet. 8 (4), 357-360 (1994) MEDLINE 95201801 REFERENCE 22 (residues 1 to 593) AUTHORS Isobe,M., Hinoda,Y., Imai,K. and Adachi,M. TITLE Chromosomal localization of an SH2 containing tyrosine phosphatase (SH-PTP3) gene to chromosome 12q24.1 JOURNAL Oncogene 9 (6), 1751-1753 (1994) MEDLINE 94239755 REFERENCE 23 (residues 1 to 593) AUTHORS Bastien,L., Ramachandran,C., Liu,S. and Adam,M. TITLE Cloning, expression and mutational analysis of SH-PTP2, human protein-tyrosine phosphatase JOURNAL Biochem. Biophys. Res. Commun. 196 (1), 124-133 (1993) MEDLINE 94029983 REFERENCE 24 (residues 1 to 593) AUTHORS Ahmad,S., Banville,D., Zhao,Z., Fischer,E.H. and Shen,S.H. TITLE A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains JOURNAL Proc. Natl. Acad. Sci. U.S.A. 90 (6), 2197-2201 (1993) MEDLINE 93211929 REFERENCE 25 (residues 1 to 593) AUTHORS Vogel,W., Lammers,R., Huang,J. and Ullrich,A. TITLE Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation JOURNAL Science 259 (5101), 1611-1614 (1993) MEDLINE 93206095 REFERENCE 26 (residues 1 to 593) AUTHORS Adachi,M., Sekiya,M., Miyachi,T., Matsuno,K., Hinoda,Y., Imai,K. and Yachi,A. TITLE Molecular cloning of a novel protein-tyrosine phosphatase SH-PTP3 with sequence similarity to the src-homology region 2 JOURNAL FEBS Lett. 314 (3), 335-339 (1992) MEDLINE 93106179 REFERENCE 27 (residues 1 to 593) AUTHORS Freeman,R.M. Jr., Plutzky,J. and Neel,B.G. TITLE Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (23), 11239-11243 (1992) MEDLINE 93087502 REFERENCE 28 (residues 1 to 593) AUTHORS Adachi,M., Sekiya,M., Arimura,Y., Takekawa,M., Itoh,F., Hinoda,Y., Imai,K. and Yachi,A. TITLE Protein-tyrosine phosphatase expression in pre-B cell NALM-6 JOURNAL Cancer Res. 52 (3), 737-740 (1992) MEDLINE 92119637 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from D13540.1 and BF515187.1. On Jan 25, 2002 this sequence version replaced gi:13430846. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Transcript Variant: This variant (1) contains a different 3' end region, and encodes a longer isoform (1), as compared to variant 2. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hSHP2_D1 (NP_002825) PTPN11| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..300 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="12" /map="12q24.1" /vntifkey="269" Protein 1..300 /product="protein tyrosine phosphatase, non-receptor type 11 isoform 1" /EC_number="3.1.3.48" /vntifkey="270" /note="protein-tyrosine phosphatase 2C; Noonan syndrome 1; protein tyrosine phosphatase, non-receptor type 11" Region 23..300 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 aeiesrvrel sklaettdkv kqgfweefet lqqqecklly srkegqrqen knknryknil 61 pfdhtrvvlh dgdpnepvsd yinaniimpe fetkcnnskp kksyiatqgc lqntvndfwr 121 mvfqensrvi vmttkeverg kskcvkywpd eyalkeygvm rvrnvkesaa hdytlrelkl 181 skvgqgnter tvwqyhfrtw pdhgvpsdpg gvldfleevh hkqesimdag pvvvhcsagi 241 grtgtfivid ilidiirekg vdcdidvpkt iqmvrsqrsg mvqteaqyrf iymavqhyie // LOCUS hSTEP_D1\( 276 aa 17-MAY-2003 DEFINITION hypothetical protein FLJ14427 [Homo sapiens]. ACCESSION NP_116170 DBSOURCE REFSEQ: accession NM_032781.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 AUTHORS Ninomiya,K., Wagatsuma,M., Kanda,K., Kondo,H., Yokoi,T., Kodaira,H., Furuya,T., Takahashi,M., Kikkawa,E., Omura,Y., Abe,K., Kamihara,K., Katsuta,N., Sato,K., Tanikawa,M., Yamazaki,M., Sugiyama,T., Irie,R., Otsuki,T., Sato,H., Wakamatsu,A., Ishii,S., Yamamoto,J., Isono,Y., Kawai-Hio,Y., Saito,K., Nishikawa,T., Kimura,K., Yamashita,H., Matsuo,K., Nakamura,Y., Sekine,M., Kikuchi,H., Murakawa,K., Kanehori,K., Takahashi-Fujii,A., Oshima,A., Sugiyama,A., Kawakami,B., Suzuki,Y., Sugano,S., Nagahari,K., Masuho,Y., Nagai,K. and Isogai,T. TITLE NEDO human cDNA sequencing project JOURNAL Unpublished COMMENT PREDICTED REFSEQ: The mRNA record is supported by experimental evidence; however, the coding sequence is predicted. The reference sequence was derived from AK090923.1. On Aug 5, 2002 this sequence version replaced gi:14249442. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hSTEP_D1 (NP_116170) PTPN5| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..276 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="11" /map="11p15.1" /clone="BRAMY2015251" /tissue_type="amygdala" /clone_lib="BRAMY2" /vntifkey="269" /note="cloning vector: pME18SFL3" Protein 1..276 /product="hypothetical protein FLJ14427" /vntifkey="270" Region 18..274 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 srvlqaeelh ekaldpfllq aeffeipmnf vdpkeydipg lvrknrykti lpnphsrvcl 61 tspdpddpls syinanyirg yggeekvyia tqgpivstva dfwrmvwqeh tpiivmitni 121 eemnekctey wpeeqvaydg veitvqkvih tedyrlrlis lksgteergl khywftswpd 181 qktpdrappl lhlvreveea aqqegphcap iivhcsagig rtgcfiatsi ccqqlrqegv 241 vdilkttcql rqdrggmiqt ceqyqfvhhv mslyek // LOCUS hTCPTP_D1\ 275 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 2 isoform 1; T-cell protein tyrosine phosphatase [Homo sapiens]. ACCESSION NP_002819 DBSOURCE REFSEQ: accession NM_002828.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 415) AUTHORS Gupta,S., Radha,V., Sudhakar,Ch. and Swarup,G. TITLE A nuclear protein tyrosine phosphatase activates p53 and induces caspase-1-dependent apoptosis JOURNAL FEBS Lett. 532 (1-2), 61-66 (2002) MEDLINE 22347239 REMARK GeneRIF: TCPTP activates p53 and induces caspase-1-dependent apoptosis in a human tumor cell line. REFERENCE 2 (residues 1 to 415) AUTHORS Yamamoto,T., Sekine,Y., Kashima,K., Kubota,A., Sato,N., Aoki,N. and Matsuda,T. TITLE The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation JOURNAL Biochem. Biophys. Res. Commun. 297 (4), 811-817 (2002) MEDLINE 22246068 REMARK GeneRIF: regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation REFERENCE 3 (residues 1 to 415) AUTHORS Zhu,W., Mustelin,T. and David,M. TITLE Arginine methylation of STAT1 regulates its dephosphorylation by T cell protein tyrosine phosphatase JOURNAL J. Biol. Chem. 277 (39), 35787-35790 (2002) MEDLINE 22229439 REMARK GeneRIF: TcPTP phosphorylation is regulated by STAT1 REFERENCE 4 (residues 1 to 415) AUTHORS ten Hoeve,J., de Jesus Ibarra-Sanchez,M., Fu,Y., Zhu,W., Tremblay,M., David,M. and Shuai,K. TITLE Identification of a nuclear Stat1 protein tyrosine phosphatase JOURNAL Mol. Cell. Biol. 22 (16), 5662-5668 (2002) MEDLINE 22133581 REMARK GeneRIF: Results identify TC45 as a protein tyrosine phosphatase responsible for the dephosphorylation of Stat1 in the nucleus. REFERENCE 5 (residues 1 to 415) AUTHORS Tiganis,T., Kemp,B.E. and Tonks,N.K. TITLE The protein-tyrosine phosphatase TCPTP regulates epidermal growth factor receptor-mediated and phosphatidylinositol 3-kinase-dependent signaling JOURNAL J. Biol. Chem. 274 (39), 27768-27775 (1999) MEDLINE 99419063 REFERENCE 6 (residues 1 to 415) AUTHORS Tiganis,T., Bennett,A.M., Ravichandran,K.S. and Tonks,N.K. TITLE Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase JOURNAL Mol. Cell. Biol. 18 (3), 1622-1634 (1998) MEDLINE 98147803 REFERENCE 7 (residues 1 to 415) AUTHORS Johnson,C.V., Cool,D.E., Glaccum,M.B., Green,N., Fischer,E.H., Bruskin,A., Hill,D.E. and Lawrence,J.B. TITLE Isolation and mapping of human T-cell protein tyrosine phosphatase sequences: localization of genes and pseudogenes discriminated using fluorescence hybridization with genomic versus cDNA probes JOURNAL Genomics 16 (3), 619-629 (1993) MEDLINE 93315152 REFERENCE 8 (residues 1 to 415) AUTHORS Mosinger,B. Jr., Tillmann,U., Westphal,H. and Tremblay,M.L. TITLE Cloning and characterization of a mouse cDNA encoding a cytoplasmic protein-tyrosine-phosphatase JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (2), 499-503 (1992) MEDLINE 92115688 REFERENCE 9 (residues 1 to 415) AUTHORS Swarup,G., Kamatkar,S., Radha,V. and Rema,V. TITLE Molecular cloning and expression of a protein-tyrosine phosphatase showing homology with transcription factors Fos and Jun JOURNAL FEBS Lett. 280 (1), 65-69 (1991) MEDLINE 91184422 REFERENCE 10 (residues 1 to 415) AUTHORS Cool,D.E., Tonks,N.K., Charbonneau,H., Walsh,K.A., Fischer,E.H. and Krebs,E.G. TITLE cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family JOURNAL Proc. Natl. Acad. Sci. U.S.A. 86 (14), 5257-5261 (1989) MEDLINE 89315776 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M25393.1, AW592324.1 and BG699440.1. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported. Transcript Variant: This variant (1) contains a different 3' region, and encodes the longest isoform (1), as compared to variant 2 and 3. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302014800| COMMENT VNTNAME|hTCPTP_D1 (NP_002819) PTPN2| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..275 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="18" /map="18p11.3-p11.2" /vntifkey="269" Protein 1..275 /product="protein tyrosine phosphatase, non-receptor type 2 isoform 1" /EC_number="3.1.3.48" /vntifkey="270" /note="T-cell protein tyrosine phosphatase" Region 3..275 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 ttierefeel dtqrrwqply leirneshdy phrvakfpen rnrnryrdvs pydhsrvklq 61 naendyinas lvdieeaqrs yiltqgplpn tcchfwlmvw qqktkavvml nrivekesvk 121 caqywptddq emlfketgfs vkllsedvks yytvhllqle ninsgetrti shfhyttwpd 181 fgvpespasf lnflfkvres gslnpdhgpa vihcsagigr sgtfslvdtc lvlmekgddi 241 nikqvllnmr kyrmgliqtp dqlrfsymai iegak // LOCUS macneIA2be 279 aa 26-JUN-2003 DEFINITION PROTEIN-TYROSINE PHOSPHATASE X PRECURSOR (R-PTP-X) (M1851). ACCESSION O02695 DBSOURCE swissprot: locus PTPX_MACNE, accession O02695; class: standard. created: Nov 1, 1997. sequence updated: Nov 1, 1997. annotation updated: May 30, 2000. xrefs: gi: 1916941, gi: 1916942 xrefs (non-sequence databases): HSSPP18052, PFAMPF00102, PROSITEPS00383, PROSITEPS50056, PROSITEPS50055 KEYWORDS Hydrolase; Receptor; Glycoprotein; Signal; Transmembrane. SOURCE Macaca nemestrina (pig-tailed macaque). ORGANISM Macaca nemestrina Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. REFERENCE 1 (residues 1 to 1013) AUTHORS LaGasse,J., Jelinek,L., Sexson,S., Lofton-Day,C., Breininger,J., Sheppard,P., Kindsvogel,W. and Hagopian,W.A. TITLE An islet-cell protein tyrosine phosphatase is a likely precursor to the 37-kDa autoantigen in type 1 diabetes: human and macaque sequences, tissue distribution, unique and shared epitopes, and predictive autoantibodies JOURNAL Mol. Med. 3 (3), 163-173 (1997) MEDLINE 97254813 REMARK SEQUENCE FROM N.A. TISSUE=PANCREATIC ISLETS COMMENT ------------------------------------------------------------------- This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. The original entry is available from http://www.expasy.ch/sprot and http://www.ebi.ac.uk/sprot ------------------------------------------------------------------. [FUNCTION] IMPLICATED IN DEVELOPMENT OF NERVOUS SYSTEM AND PANCREATIC ENDOCRINE CELLS. [CATALYTIC ACTIVITY] PROTEIN TYROSINE PHOSPHATE + H(2)O = PROTEIN TYROSINE + ORTHOPHOSPHATE. [SUBCELLULAR LOCATION] TYPE I MEMBRANE PROTEIN (PROBABLE). [TISSUE SPECIFICITY] BRAIN, PROSTATE, PANCREATIC ISLETS. LOWER EXPRESSION IN SPINAL CORD, THYROID, ADRENAL MEDULLA AND GASTROINTESTINAL TRACT. [PTM] APPEARS TO UNDERGO MULTIPLE PROTEOLYTIC CLEAVAGE AT CONSECUTIVE BASIC RESIDUES (BY SIMILARITY). [SIMILARITY] CONTAINS 1 PROTEIN-TYROSINE PHOSPHATASE DOMAIN. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|306376459| COMMENT VNTNAME|macneIA2beta_D1 (O02695)| COMMENT VNTAUTHORNAME|JNA| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..279 /organism="Macaca nemestrina" /db_xref="taxon:9545" /vntifkey="269" Protein 1..279 /gene="PTPRN2" /product="PROTEIN-TYROSINE PHOSPHATASE X PRECURSOR" /EC_number="3.1.3.48" /vntifkey="270" Region 1..279 /gene="PTPRN2" /region_name="Mature chain" /vntifkey="203" /label=PTPRN2 /note="PROTEIN-TYROSINE PHOSPHATASE X." Region 1..279 /gene="PTPRN2" /region_name="Domain" /vntifkey="1004" /label=PTPRN2 /note="CYTOPLASMIC (POTENTIAL)." Region 42..276 /gene="PTPRN2" /region_name="Domain" /vntifkey="1000" /label=PTPRN2 /note="PROTEIN-TYROSINE PHOSPHATASE." Site 217..217 /gene="PTPRN2" /site_type="active" /vntifkey="220" /label=PTPRN2 /note="POTENTIAL." ORIGIN 1 hmilsymedh lknknrleke wealcayqae pnsslvaqke envpknrsla vltydhsrvl 61 lkaenshshs dyinaspimd hdprnpayia tqgplpatva dfwqmvwesg cvvivmltpl 121 tengvrqcyh ywpdegsnly hiyevnlvse hiwcedflvr sfylknlqtn etrtvtqfhf 181 lswydrgvps ssrslldfrr kvnkcyrgrs cpiivhcsdg agrsgtyvli dmvlnkmakg 241 akeidiaatl ehlrdqrpgm vqtkeqfefa ltavaeevn // LOCUS mCD45_D1\( 279 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, C [Mus musculus]. ACCESSION NP_035340 DBSOURCE REFSEQ: accession NM_011210.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 1152) AUTHORS Irles,C., Symons,A., Michel,F., Bakker,T.R., van der Merwe,P.A. and Acuto,O. TITLE CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling JOURNAL Nat. Immunol. 4 (2), 189-197 (2003) MEDLINE 22442648 REMARK GeneRIF: the large CD45 ectodomain is required for optimal TCR signaling REFERENCE 2 (residues 1 to 1152) AUTHORS Edmonds,S.D. and Ostergaard,H.L. TITLE Dynamic association of CD45 with detergent-insoluble microdomains in T lymphocytes JOURNAL J. Immunol. 169 (9), 5036-5042 (2002) MEDLINE 22278638 REMARK GeneRIF: CD45 is present in lipid rafts in T cells before activation, perhaps to activate raft-associated p56(lck), allowing membrane-proximal signaling events to proceed. REFERENCE 3 (residues 1 to 1152) AUTHORS Freiberg,B.A., Kupfer,H., Maslanik,W., Delli,J., Kappler,J., Zaller,D.M. and Kupfer,A. TITLE Staging and resetting T cell activation in SMACs JOURNAL Nat. Immunol. 3 (10), 911-917 (2002) MEDLINE 22239831 REMARK GeneRIF: we studied intracellular signaling in SMACs by three-dimensional immunofluorescence microscopic localization of CD3, CD45, talin, phosphotyrosine, Lck and phosphorylated ZAP-70 in T cell-APC conjugates REFERENCE 4 (residues 1 to 1152) AUTHORS He,X., Woodford-Thomas,T.A., Johnson,K.G., Shah,D.D. and Thomas,M.L. TITLE Targeting of CD45 protein tyrosine phosphatase activity to lipid microdomains on the T cell surface inhibits TCR signaling JOURNAL Eur. J. Immunol. 32 (9), 2578-2587 (2002) MEDLINE 22195589 REMARK GeneRIF: Segregation of CD45 from proximal TCR signaling components is necessary for TCR signaling and that the targeting of CD45 PTP activity to lipid microdomains on the T cell surface results in decreased sensitivity of TCR-mediated signaling. REFERENCE 5 (residues 1 to 1152) AUTHORS Bakker,T.R., Piperi,C., Davies,E.A. and Merwe,P.A. TITLE Comparison of CD22 binding to native CD45 and synthetic oligosaccharide JOURNAL Eur. J. Immunol. 32 (7), 1924-1932 (2002) MEDLINE 22110087 REMARK GeneRIF: CD22 binding to native CD45 REFERENCE 6 (residues 1 to 1152) AUTHORS Martin,P., Del Hoyo,G.M., Anjuere,F., Arias,C.F., Vargas,H.H., Fernandez-L,A., Parrillas,V. and Ardavin,C. TITLE Characterization of a new subpopulation of mouse CD8alpha+ B220+ dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential JOURNAL Blood 100 (2), 383-390 (2002) MEDLINE 22085803 REMARK GeneRIF: Characterization of a new subpopulation of mouse CD8alpha+ B220+ dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential. REFERENCE 7 (residues 1 to 1152) AUTHORS Fortin,M., Steff,A.M., Felberg,J., Ding,I., Schraven,B., Johnson,P. and Hugo,P. TITLE Apoptosis mediated through CD45 is independent of its phosphatase activity and association with leukocyte phosphatase-associated phosphoprotein JOURNAL J. Immunol. 168 (12), 6084-6089 (2002) MEDLINE 22050741 REMARK GeneRIF: The extracellular and/or the transmembrane portion of CD45 has a major role in apoptosis signaling which is independent of its phosphatase activity and association with leukocyte phosphatase-associated phosphoprotein. REFERENCE 8 (residues 1 to 1152) AUTHORS Tchilian,E.Z. and Beverley,P.C. TITLE CD45 in memory and disease JOURNAL Arch. Immunol. Ther. Exp. (Warsz.) 50 (2), 85-93 (2002) MEDLINE 22017393 REMARK GeneRIF: Role of high and low molecular weight isoforms of CD45 in the function of na##ve and memory T lymphocytes. Review. REFERENCE 9 (residues 1 to 1152) AUTHORS Brooks,W.P. and Lynes,M.A. TITLE Effects of hemizygous CD45 expression in the autoimmune Fasl(gld/gld) syndrome JOURNAL Cell. Immunol. 212 (1), 24-34 (2001) MEDLINE 21573815 REMARK GeneRIF: These data indicate that CD45 is essential to the accumulation of CD4(-)/CD8(-) (DN) T cells in Fasl(gld/gld) mice REFERENCE 10 (residues 1 to 1152) AUTHORS Arendt,C.W. and Ostergaard,H.L. TITLE Identification of the CD45-associated 116-kDa and 80-kDa proteins as the alpha- and beta-subunits of alpha-glucosidase II JOURNAL J. Biol. Chem. 272 (20), 13117-13125 (1997) MEDLINE 97294720 REFERENCE 11 (residues 1 to 1152) AUTHORS Zebedee,S.L., Barritt,D.S. and Raschke,W.C. TITLE Comparison of mouse Ly5a and Ly5b leucocyte common antigen alleles JOURNAL Dev. Immunol. 1 (4), 243-254 (1991) MEDLINE 92361152 REFERENCE 12 (residues 1 to 1152) AUTHORS Raschke,W.C. TITLE Cloned murine T200 (Ly-5) cDNA reveals multiple transcripts within B- and T-lymphocyte lineages JOURNAL Proc. Natl. Acad. Sci. U.S.A. 84 (1), 161-165 (1987) MEDLINE 87092355 REFERENCE 13 (residues 1 to 1152) AUTHORS Saga,Y., Tung,J.S., Shen,F.W. and Boyse,E.A. TITLE Sequences of Ly-5 cDNA: isoform-related diversity of Ly-5 mRNA JOURNAL Proc. Natl. Acad. Sci. U.S.A. 83 (18), 6940-6944 (1986) MEDLINE 86313686 REFERENCE 14 (residues 1 to 1152) AUTHORS Shen,F.W., Saga,Y., Litman,G., Freeman,G., Tung,J.S., Cantor,H. and Boyse,E.A. TITLE Cloning of Ly-5 cDNA JOURNAL Proc. Natl. Acad. Sci. U.S.A. 82 (21), 7360-7363 (1985) MEDLINE 86042665 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M14342.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302132248| COMMENT VNTNAME|mCD45_D1 (NP_035340) Ptprc| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..279 /organism="Mus musculus" /db_xref="taxon:10090" /chromosome="1" /map="1 74.0 cM" /cell_type="T-cell" /vntifkey="269" Protein 1..279 /product="protein tyrosine phosphatase, receptor type, C" /vntifkey="270" Region 17..277 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 dilletykrk iadegrlfla efqsiprvfs kfpikdarkp hnqnknryvd ilpydynrve 61 lseingdags tyinasyidg fkeprkyiaa qgprdetvdd fwrmiweqka tvivmvtrce 121 egnrnkcaey wpsmeegtra fkdivvtind hkrcpdyiiq klnvahkkek atgrevthiq 181 ftswpdhgvp edphlllklr rrvnafsnff sgpivvhcsa gvgrtgtyig idamleglea 241 egkvdvygyv vklrrqrclm vqveaqyili hqalveynq // LOCUS mDEP1_D1\( 277 aa 27-JUN-2003 DEFINITION protein tyrosine phosphatase, receptor type, J; colon tumor susceptibility 1 [Mus musculus]. ACCESSION NP_033008 DBSOURCE REFSEQ: accession NM_008982.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 1238) AUTHORS Takahashi,T., Takahashi,K., St John,P.L., Fleming,P.A., Tomemori,T., Watanabe,T., Abrahamson,D.R., Drake,C.J., Shirasawa,T. and Daniel,T.O. TITLE A mutant receptor tyrosine phosphatase, CD148, causes defects in vascular development JOURNAL Mol. Cell. Biol. 23 (5), 1817-1831 (2003) MEDLINE 22477405 REMARK GeneRIF: CD148 has a role in developmental vascular organization and regulates endothelial proliferation and endothelium-pericyte interactions REFERENCE 2 (residues 1 to 1238) AUTHORS Ruivenkamp,C.A., van Wezel,T., Zanon,C., Stassen,A.P., Vlcek,C., Csikos,T., Klous,A.M., Tripodis,N., Perrakis,A., Boerrigter,L., Groot,P.C., Lindeman,J., Mooi,W.J., Meijjer,G.A., Scholten,G., Dauwerse,H., Paces,V., van Zandwijk,N., van Ommen,G.J. and Demant,P. TITLE Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers JOURNAL Nat. Genet. 31 (3), 295-300 (2002) MEDLINE 22084388 REMARK GeneRIF: This protein is a candidate for the mouse colon cancer susceptibility locus (Scc1). REFERENCE 3 (residues 1 to 1238) AUTHORS Kuramochi,S., Matsuda,S., Matsuda,Y., Saitoh,T., Ohsugi,M. and Yamamoto,T. TITLE Molecular cloning and characterization of Byp, a murine receptor-type tyrosine phosphatase similar to human DEP-1 JOURNAL FEBS Lett. 378 (1), 7-14 (1996) MEDLINE 96140699 REFERENCE 4 (residues 1 to 1238) AUTHORS van Wezel,T., Ruivenkamp,C.A.L., Zanon,C., Stassen,A.P.M., Vlcek,C., Csikos,T., Tripodis,N., Groot,P.C., Dauwerse,H., van Ommen,G.J.B. and Demant,P. TITLE Positional cloning identifies Ptprj as the candidate for colon cancer susceptibility QTL Scc1 JOURNAL Unpublished COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY038891.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|306456187| COMMENT VNTNAME|mDEP1_D1 (NP_033008) Ptprj| COMMENT VNTAUTHORNAME|JNA| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..277 /organism="Mus musculus" /strain="BALB/c" /db_xref="taxon:10090" /chromosome="2" /map="2 49.5 cM" /vntifkey="269" Protein 1..277 /product="protein tyrosine phosphatase, receptor type, J" /vntifkey="270" /note="colon tumor susceptibility 1" Region 17..277 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 enfeayfkkq qadsncgfae eyedlkligi slpkytaeia enrgknrynn vlpydisrvk 61 lsvqthstdd yinanympgy hskkdfiatq gplpntlkdf wrmvweknvy aivmltkcve 121 qgrtkceeyw pskqaqdygd itvamtsevv lpewtirdfv vknmqnsesh plrqfhftsw 181 pdhgvpdttd llinfrylvr dymkqippes pilvhcsagv grtgtfiaid rliyqienen 241 tvdvygivyd lrmhrplmvq tedqyvflnq cvldiir // LOCUS mHDPTP_D1\ 286 aa 30-JUN-2003 DEFINITION AI462446 protein [Mus musculus]. ACCESSION AAH22721 DBSOURCE accession BC022721.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 496) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) MEDLINE 22388257 REFERENCE 2 (residues 1 to 496) AUTHORS Strausberg,R. TITLE Direct Submission JOURNAL Submitted (01-FEB-2002) National Institutes of Health, Mammalian Gene Collection (MGC), Cancer Genomics Office, National Cancer Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: The Cepko Laboratory cDNA Library Preparation: Life Technologies, Inc. cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: Sequencing Group at the Stanford Human Genome Center, Stanford University School of Medicine, Stanford, CA 94305 Web site: http://www-shgc.stanford.edu Contact: (Dickson, Mark) mcd@paxil.stanford.edu Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers, R. M. Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAK Plate: 44 Row: e Column: 12 This clone was selected for full length sequencing because it passed the following selection criteria: Hexamer frequency ORF analysis. Method: conceptual translation. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|306769633| COMMENT VNTNAME|mHDPTP_D1 (AAH22721)| COMMENT VNTAUTHORNAME|JNA| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|UNKNOWN| FEATURES Location/Qualifiers source 1..286 /organism="Mus musculus" /db_xref="taxon:10090" /clone="IMAGE:4502143" /tissue_type="Eye, retina, mouse strain C57Bl\6" /clone_lib="NIH_MGC_94" /lab_host="DH10B" /vntifkey="269" /note="Vector: pCMV-SPORT6" Protein 1..286 /product="AI462446 protein" /vntifkey="270" ORIGIN 1 erlqqlqqel eafrgqlgda galdaiwrel qeaqehdarg rsiaiarcys lknrhqdvmp 61 ydsnrvvlrs gkddyinasc veglspycpp lvatqaplpg taadfwlmvh eqkvsvivml 121 vseaemekqk varyfpterg qpmvhgalsv alssirttet hvervlslqf rdqslkrslv 181 hlhfptwpel glpdspgnll rfiqevhahy lhqrplhtpi vvhcssgvgr tgafallyaa 241 vqeveagngi pelpqlvrrm rqqrkhmlqe klhlkfchea lvrhve // LOCUS mHePTP_D1\ 272 aa 30-JUN-2003 DEFINITION RIKEN cDNA C920001D21 gene [Mus musculus]. ACCESSION NP_796055 DBSOURCE REFSEQ: accession NM_177081.2 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 359) AUTHORS Okazaki,Y., Furuno,M., Kasukawa,T., Adachi,J., Bono,H., Kondo,S., Nikaido,I., Osato,N., Saito,R., Suzuki,H., Yamanaka,I., Kiyosawa,H., Yagi,K., Tomaru,Y., Hasegawa,Y., Nogami,A., Schonbach,C., Gojobori,T., Baldarelli,R., Hill,D.P., Bult,C., Hume,D.A., Quackenbush,J., Schriml,L.M., Kanapin,A., Matsuda,H., Batalov,S., Beisel,K.W., Blake,J.A., Bradt,D., Brusic,V., Chothia,C., Corbani,L.E., Cousins,S., Dalla,E., Dragani,T.A., Fletcher,C.F., Forrest,A., Frazer,K.S., Gaasterland,T., Gariboldi,M., Gissi,C., Godzik,A., Gough,J., Grimmond,S., Gustincich,S., Hirokawa,N., Jackson,I.J., Jarvis,E.D., Kanai,A., Kawaji,H., Kawasawa,Y., Kedzierski,R.M., King,B.L., Konagaya,A., Kurochkin,I.V., Lee,Y., Lenhard,B., Lyons,P.A., Maglott,D.R., Maltais,L., Marchionni,L., McKenzie,L., Miki,H., Nagashima,T., Numata,K., Okido,T., Pavan,W.J., Pertea,G., Pesole,G., Petrovsky,N., Pillai,R., Pontius,J.U., Qi,D., Ramachandran,S., Ravasi,T., Reed,J.C., Reed,D.J., Reid,J., Ring,B.Z., Ringwald,M., Sandelin,A., Schneider,C., Semple,C.A., Setou,M., Shimada,K., Sultana,R., Takenaka,Y., Taylor,M.S., Teasdale,R.D., Tomita,M., Verardo,R., Wagner,L., Wahlestedt,C., Wang,Y., Watanabe,Y., Wells,C., Wilming,L.G., Wynshaw-Boris,A., Yanagisawa,M., Yang,I., Yang,L., Yuan,Z., Zavolan,M., Zhu,Y., Zimmer,A., Carninci,P., Hayatsu,N., Hirozane-Kishikawa,T., Konno,H., Nakamura,M., Sakazume,N., Sato,K., Shiraki,T., Waki,K., Kawai,J., Aizawa,K., Arakawa,T., Fukuda,S., Hara,A., Hashizume,W., Imotani,K., Ishii,Y., Itoh,M., Kagawa,I., Miyazaki,A., Sakai,K., Sasaki,D., Shibata,K., Shinagawa,A., Yasunishi,A., Yoshino,M., Waterston,R., Lander,E.S., Rogers,J., Birney,E. and Hayashizaki,Y. TITLE Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs JOURNAL Nature 420 (6915), 563-573 (2002) MEDLINE 22354683 REFERENCE 2 AUTHORS The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I & II Team. TITLE Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs JOURNAL Nature 420, 563-573 (2002) REFERENCE 3 AUTHORS Kawai,J., Shinagawa,A., Shibata,K., Yoshino,M., Itoh,M., Ishii,Y., Arakawa,T., Hara,A., Fukunishi,Y., Konno,H., Adachi,J., Fukuda,S., Aizawa,K., Izawa,M., Nishi,K., Kiyosawa,H., Kondo,S., Yamanaka,I., Saito,T., Okazaki,Y., Gojobori,T., Bono,H., Kasukawa,T., Saito,R., Kadota,K., Matsuda,H., Ashburner,M., Batalov,S., Casavant,T., Fleischmann,W., Gaasterland,T., Gissi,C., King,B., Kochiwa,H., Kuehl,P., Lewis,S., Matsuo,Y., Nikaido,I., Pesole,G., Quackenbush,J., Schriml,L.M., Staubli,F., Suzuki,R., Tomita,M., Wagner,L., Washio,T., Sakai,K., Okido,T., Furuno,M., Aono,H., Baldarelli,R., Barsh,G., Blake,J., Boffelli,D., Bojunga,N., Carninci,P., de Bonaldo,M.F., Brownstein,M.J., Bult,C., Fletcher,C., Fujita,M., Gariboldi,M., Gustincich,S., Hill,D., Hofmann,M., Hume,D.A., Kamiya,M., Lee,N.H., Lyons,P., Marchionni,L., Mashima,J., Mazzarelli,J., Mombaerts,P., Nordone,P., Ring,B., Ringwald,M., Rodriguez,I., Sakamoto,N., Sasaki,H., Sato,K., Schonbach,C., Seya,T., Shibata,Y., Storch,K.F., Suzuki,H., Toyo-oka,K., Wang,K.H., Weitz,C., Whittaker,C., Wilming,L., Wynshaw-Boris,A., Yoshida,K., Hasegawa,Y., Kawaji,H., Kohtsuki,S. and Hayashizaki,Y. TITLE Functional annotation of a full-length mouse cDNA collection JOURNAL Nature 409 (6821), 685-690 (2001) MEDLINE 21085660 REFERENCE 4 AUTHORS Shibata,K., Itoh,M., Aizawa,K., Nagaoka,S., Sasaki,N., Carninci,P., Konno,H., Akiyama,J., Nishi,K., Kitsunai,T., Tashiro,H., Itoh,M., Sumi,N., Ishii,Y., Nakamura,S., Hazama,M., Nishine,T., Harada,A., Yamamoto,R., Matsumoto,H., Sakaguchi,S., Ikegami,T., Kashiwagi,K., Fujiwake,S., Inoue,K. and Togawa,Y. TITLE RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer JOURNAL Genome Res. 10 (11), 1757-1771 (2000) MEDLINE 20530913 REFERENCE 5 AUTHORS Carninci,P., Shibata,Y., Hayatsu,N., Sugahara,Y., Shibata,K., Itoh,M., Konno,H., Okazaki,Y., Muramatsu,M. and Hayashizaki,Y. TITLE Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes JOURNAL Genome Res. 10 (10), 1617-1630 (2000) MEDLINE 20499374 REFERENCE 6 AUTHORS Carninci,P. and Hayashizaki,Y. TITLE High-efficiency full-length cDNA cloning JOURNAL Meth. Enzymol. 303, 19-44 (1999) MEDLINE 99279253 COMMENT PREDICTED REFSEQ: The mRNA record is supported by experimental evidence; however, the coding sequence is predicted. The reference sequence was derived from AK083305.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|306769567| COMMENT VNTNAME|mHePTP_D1 (NP_796055) Ptpn7| COMMENT VNTAUTHORNAME|JNA| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|UNKNOWN| FEATURES Location/Qualifiers source 1..272 /organism="Mus musculus" /strain="C57BL/6J" /db_xref="taxon:10090" /chromosome="1" /vntifkey="269" Protein 1..272 /product="RIKEN cDNA C920001D21 gene" /vntifkey="270" Region 17..270 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 hpltrwtlqh qppspkqlee eflkipsnfv npedldipgh askdryktil pnpqsrvclg 61 raqsqedsdy inanyirgyd gkekvyiatq gpmpntvadf wemvwqedvs livmltqlre 121 gkekcvhywp teeeaygpfq iriqdmkehp eytvrqltiq hqqecrsvkh ilfsawpdhq 181 tpesagpllr lvaevetpet aansgpivvh csagigrtgc fiatrigcqq lkargevdil 241 givcqlrldr ggmiqtaeqy qflhhtlaly aa // LOCUS mIA2_D1\(N 279 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, N; protein tyrosine phosphatase, receptor-type, N [Mus musculus]. ACCESSION NP_033011 DBSOURCE REFSEQ: accession NM_008985.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 996) AUTHORS Saeki,K., Zhu,M., Kubosaki,A., Xie,J., Lan,M.S. and Notkins,A.L. TITLE Targeted disruption of the protein tyrosine phosphatase-like molecule IA-2 results in alterations in glucose tolerance tests and insulin secretion JOURNAL Diabetes 51 (6), 1842-1850 (2002) MEDLINE 22027598 REMARK GeneRIF: IA-2 is involved in glucose-stimulated insulin secretion REFERENCE 2 (residues 1 to 996) AUTHORS Kudva,Y.C., Deng,Y.J., Govindarajan,R., Abraham,R.S., Marietta,E.V., Notkins,A.L. and David,C.S. TITLE HLA-DQ8 transgenic and NOD mice recognize different epitopes within the cytoplasmic region of the tyrosine phosphatase-like molecule, IA-2 JOURNAL Hum. Immunol. 62 (10), 1099-1105 (2001) MEDLINE 21486216 REMARK GeneRIF: IA-2 peptides have been identified that induce lymphoproliferative responses in DQ8 transgenic and NOD mice and stimulate production of Th1 and Th2 cytokines. REFERENCE 3 (residues 1 to 996) AUTHORS Ehringer,M.A., Thompson,J., Conroy,O., Xu,Y., Yang,F., Canniff,J., Beeson,M., Gordon,L., Bennett,B., Johnson,T.E. and Sikela,J.M. TITLE High-throughput sequence identification of gene coding variants within alcohol-related QTLs JOURNAL Mamm. Genome 12 (8), 657-663 (2001) MEDLINE 21363810 REFERENCE 4 (residues 1 to 996) AUTHORS Saeki,K., Xie,J. and Notkins,A.L. TITLE Genomic structure of mouse IA-2: comparison with its human homologue JOURNAL Diabetologia 43 (11), 1429-1434 (2000) MEDLINE 21012487 REFERENCE 5 AUTHORS Magistrelli,G., Covini,N., Mosca,M., Lippoli,G. and Isacchi,A. TITLE Expression of PTP35, the murine homologue of the protein tyrosine phosphatase-related sequence IA-2, is regulated during cell growth and stimulated by mitogens in 3T3 fibroblasts JOURNAL Biochem. Biophys. Res. Commun. 217 (1), 154-161 (1995) MEDLINE 96095652 REFERENCE 6 (residues 1 to 996) AUTHORS Hendriks,W., Schepens,J., Brugman,C., Zeeuwen,P. and Wieringa,B. TITLE A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain JOURNAL Biochem. J. 305 (Pt 2), 499-504 (1995) MEDLINE 95134232 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X74438.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302142060| COMMENT VNTNAME|mIA2_D1 (NP_033011) Ptprn| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..279 /organism="Mus musculus" /strain="Swiss" /db_xref="taxon:10090" /chromosome="1" /map="1 41.0 cM" /vntifkey="269" Protein 1..279 /product="protein tyrosine phosphatase, receptor type, N" /vntifkey="270" /note="protein tyrosine phosphatase, receptor-type, N" Region 17..278 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 hmilaymedh lrnrdrlake wqalcayqae pntcaaaqde snikknrhpd flpydharik 61 lkvesspsrs dyinaspiie hdprmpayia tqgplshtia dfwqmvwesg ctvivmltpl 121 vedgvkqcdr ywpdegssly hvyevnlvse hiwcedflvr sfylknvqtq etrtltqfhf 181 lswpaegtpa strplldfrr kvnkcyrgrs cpiivhcsdg agrtgtyili dmvlnrmakg 241 vkeidiaatl ehvrdqrpgl vrskdqfefa ltavaeevn // LOCUS mLAR_D1\(N 275 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, F; protein tyrosine phosphatase, receptor-type, F [Mus musculus]. ACCESSION NP_035343 DBSOURCE REFSEQ: accession NM_011213.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 1898) AUTHORS Zeng,L., Si,X., Yu,W.P., Le,H.T., Ng,K.P., Teng,R.M., Ryan,K., Wang,D.Z., Ponniah,S. and Pallen,C.J. TITLE PTP alpha regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migration JOURNAL J. Cell Biol. 160 (1), 137-146 (2003) MEDLINE 22403956 REMARK GeneRIF: PTP alpha is required for integrin-proximal events and phosphorylates FAK REFERENCE 2 (residues 1 to 1898) AUTHORS Terszowski,G., Jankowski,A., Hendriks,W.J., Rolink,A.G. and Kisielow,P. TITLE Within the hemopoietic system, LAR phosphatase is a T cell lineage-specific adhesion receptor-like protein whose phosphatase activity appears dispensable for T cell development, repertoire selection and function JOURNAL Eur. J. Immunol. 31 (3), 832-840 (2001) MEDLINE 21135493 REFERENCE 3 (residues 1 to 1898) AUTHORS Schaapveld,R.Q., van den Maagdenberg,A.M., Schepens,J.T., Weghuis,D.O., Geurts van Kessel,A., Wieringa,B. and Hendriks,W.J. TITLE The mouse gene Ptprf encoding the leukocyte common antigen-related molecule LAR: cloning, characterization, and chromosomal localization JOURNAL Genomics 27 (1), 124-130 (1995) MEDLINE 95394448 REFERENCE 4 (residues 1 to 1898) AUTHORS Hendriks,W., Schepens,J., Brugman,C., Zeeuwen,P. and Wieringa,B. TITLE A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain JOURNAL Biochem. J. 305 (Pt 2), 499-504 (1995) MEDLINE 95134232 REFERENCE 5 (residues 1 to 1898) AUTHORS Schepens,J., Zeeuwen,P., Wieringa,B. and Hendriks,W. TITLE Identification and typing of members of the protein-tyrosine phosphatase gene family expressed in mouse brain JOURNAL Mol. Biol. Rep. 16 (4), 241-248 (1992) MEDLINE 93086603 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF300943.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302132731| COMMENT VNTNAME|mLAR_D1 (NP_035343) Ptprf| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..275 /organism="Mus musculus" /db_xref="taxon:10090" /chromosome="4" /tissue_type="thymus" /vntifkey="269" Protein 1..275 /product="protein tyrosine phosphatase, receptor type, F" /vntifkey="270" /note="protein tyrosine phosphatase, receptor-type, F" Region 17..275 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_4 /note="PTPc" ORIGIN 1 tdladnierl kandglkfsq eyesidpgqq ftwensnsev nkpknryadv iaydhsrvll 61 tsidgvpgsd yinanyidgy rkqnayiatq gplpetmgdf wrmvweqrta tvvmmtrlee 121 ksrvkcdqyw pvrgtetygl iqvtlvdtve latytmrtfa lhksgssekr elrqfqfmaw 181 pdhgvpeypt pilaflrrvk acnpldagpm vvhcsagvgr tgcfividam lermkhektv 241 diyghvtcmr sqrnymvqte dqyvfiheal leaam // LOCUS mMEG1_D1\( 277 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 4; testis-enriched protein tyrosine phosphatase; TEP/mPTPMEG; testis-enriched phosphatase; protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) [Mus musculus]. ACCESSION NP_064317 DBSOURCE REFSEQ: accession NM_019933.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 926) AUTHORS Park,K.W., Lee,E.J., Lee,S., Lee,J.E., Choi,E., Kim,B.J., Hwang,R., Park,K.A. and Baik,J. TITLE Molecular cloning and characterization of a protein tyrosine phosphatase enriched in testis, a putative murine homologue of human PTPMEG JOURNAL Gene 257 (1), 45-55 (2000) MEDLINE 20510023 REFERENCE 2 (residues 1 to 926) AUTHORS Celler,J.W., Luo,X. and Bohmer,F.D. TITLE Protein tyrosine phosphatase gene expression analysis in Swiss 3T3 fibroblasts JOURNAL Mol. Cell. Biochem. 178 (1-2), 157-162 (1998) MEDLINE 98206672 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF106702.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302142016| COMMENT VNTNAME|mMEG1_D1 (NP_064317) Ptpn4| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..277 /organism="Mus musculus" /db_xref="taxon:10090" /chromosome="1" /tissue_type="testis" /vntifkey="269" Protein 1..277 /product="protein tyrosine phosphatase, non-receptor type 4" /vntifkey="270" /note="similar to Homo sapiens megakaryocyte PTPase MEG-01; non-receptor type PTPase; contains Band 4.1-like and catalytic phosphatase domains; contains SH3 and DHR (PDZ) motifs that function as adaptor sequences; testis-enriched protein tyrosine phosphatase; TEP/mPTPMEG; testis-enriched phosphatase; protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)" Region 19..277 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 hslresmiql aeglitgtvl aqfdqlyrkk pgmtmscakl pqnisknryr dispydatrv 61 llkgnedyin anyinmeips ssiinqyiac qgplphtckd fwqmiweqgs smvvmlttqv 121 ergrvkchqy wpepsesssy gcyqatchse egnpayifrk mtlinqekne srqltqiqyt 181 awpdhgvpdd ssdfldfvch vrdqragkee piivhcsagi grtgvlitme tamcliecnq 241 pvypldivrt mrdqrammiq tpsqyrfvce ailkvye // LOCUS mMEG2_D1\( 291 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 9; protein-tyrosine phosphatase [Mus musculus]. ACCESSION NP_062625 DBSOURCE REFSEQ: accession NM_019651.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 593) AUTHORS Kawai,J., Shinagawa,A., Shibata,K., Yoshino,M., Itoh,M., Ishii,Y., Arakawa,T., Hara,A., Fukunishi,Y., Konno,H., Adachi,J., Fukuda,S., Aizawa,K., Izawa,M., Nishi,K., Kiyosawa,H., Kondo,S., Yamanaka,I., Saito,T., Okazaki,Y., Gojobori,T., Bono,H., Kasukawa,T., Saito,R., Kadota,K., Matsuda,H., Ashburner,M., Batalov,S., Casavant,T., Fleischmann,W., Gaasterland,T., Gissi,C., King,B., Kochiwa,H., Kuehl,P., Lewis,S., Matsuo,Y., Nikaido,I., Pesole,G., Quackenbush,J., Schriml,L.M., Staubli,F., Suzuki,R., Tomita,M., Wagner,L., Washio,T., Sakai,K., Okido,T., Furuno,M., Aono,H., Baldarelli,R., Barsh,G., Blake,J., Boffelli,D., Bojunga,N., Carninci,P., de Bonaldo,M.F., Brownstein,M.J., Bult,C., Fletcher,C., Fujita,M., Gariboldi,M., Gustincich,S., Hill,D., Hofmann,M., Hume,D.A., Kamiya,M., Lee,N.H., Lyons,P., Marchionni,L., Mashima,J., Mazzarelli,J., Mombaerts,P., Nordone,P., Ring,B., Ringwald,M., Rodriguez,I., Sakamoto,N., Sasaki,H., Sato,K., Schonbach,C., Seya,T., Shibata,Y., Storch,K.F., Suzuki,H., Toyo-oka,K., Wang,K.H., Weitz,C., Whittaker,C., Wilming,L., Wynshaw-Boris,A., Yoshida,K., Hasegawa,Y., Kawaji,H., Kohtsuki,S. and Hayashizaki,Y. TITLE Functional annotation of a full-length mouse cDNA collection JOURNAL Nature 409 (6821), 685-690 (2001) MEDLINE 21085660 REFERENCE 2 (residues 1 to 593) AUTHORS Shibata,K., Itoh,M., Aizawa,K., Nagaoka,S., Sasaki,N., Carninci,P., Konno,H., Akiyama,J., Nishi,K., Kitsunai,T., Tashiro,H., Itoh,M., Sumi,N., Ishii,Y., Nakamura,S., Hazama,M., Nishine,T., Harada,A., Yamamoto,R., Matsumoto,H., Sakaguchi,S., Ikegami,T., Kashiwagi,K., Fujiwake,S., Inoue,K. and Togawa,Y. TITLE RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer JOURNAL Genome Res. 10 (11), 1757-1771 (2000) MEDLINE 20530913 REFERENCE 3 (residues 1 to 593) AUTHORS Carninci,P., Shibata,Y., Hayatsu,N., Sugahara,Y., Shibata,K., Itoh,M., Konno,H., Okazaki,Y., Muramatsu,M. and Hayashizaki,Y. TITLE Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes JOURNAL Genome Res. 10 (10), 1617-1630 (2000) MEDLINE 20499374 REFERENCE 4 (residues 1 to 593) AUTHORS Carninci,P. and Hayashizaki,Y. TITLE High-efficiency full-length cDNA cloning JOURNAL Meth. Enzymol. 303, 19-44 (1999) MEDLINE 99279253 REFERENCE 5 (residues 1 to 593) AUTHORS Meng,K., Gu,M., Li,F.N., Veile,R.A., Donis-Keller,H. and Majerus,P.W. TITLE MPTP-MEG2 JOURNAL Unpublished COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF013490.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302141969| COMMENT VNTNAME|mMEG2_D1 (NP_062625) Ptpn9| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..291 /organism="Mus musculus" /db_xref="taxon:10090" /chromosome="9" /vntifkey="269" Protein 1..291 /product="protein tyrosine phosphatase, non-receptor type 9" /vntifkey="270" /note="protein-tyrosine phosphatase" Region 17..291 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 mtiqelvdyv ntrqkrgiye eyediclenp vgtfhrtmsp rnleknrygd vpcldqtrvk 61 ltkrsghtqt dyinasfmdg ykqknayngt qgplentyrd fwlmvweqkv lvivmttrfe 121 eggrrkcgqy wplekdsrir fgfltvtnlg venmnhykkt tleihnteer qkrqvthfqf 181 lswpdygvps saaslidflr vvrnqqsmav gnmgarskgq cpeppivvhc sagigrtgtf 241 csldiclaql eelgtlnvfh tvsrmrtqra fsiqtpeqyy fcykailefa q // LOCUS mPEP_D1\(N 287 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 8 [Mus musculus]. ACCESSION NP_033005 DBSOURCE REFSEQ: accession NM_008979.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 802) AUTHORS Matthews,R.J., Bowne,D.B., Flores,E. and Thomas,M.L. TITLE Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences JOURNAL Mol. Cell. Biol. 12 (5), 2396-2405 (1992) MEDLINE 92236615 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M90388.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302143146| COMMENT VNTNAME|mPEP_D1 (NP_033005) Ptpn8| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..287 /organism="Mus musculus" /db_xref="taxon:10090" /chromosome="3" /vntifkey="269" Protein 1..287 /product="protein tyrosine phosphatase, non-receptor type 8" /vntifkey="270" Region 20..287 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 eilqqllkea qkkklnseef aseflklkrq stkykadkiy pttvaqrpkn ikknrykdil 61 pydhslvels lltsdedssy inasfikgvy gpkayiatqg plsttlldfw rmiweyrilv 121 ivmacmefem gkkkcerywa epgetqlqfg pfsisceaek kksdykirtl kakfnnetri 181 iyqfhyknwp dhdvpssidp ilqliwdmrc yqeddcvpic ihcsagcgrt gvicavdytw 241 mllkdgiipk nfsvfnliqe mrtqrpslvq tqeqyelvys avlelfk // LOCUS mPEST_D1\( 288 aa 4-JUL-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 12 [Mus musculus]. ACCESSION NP_035333 DBSOURCE REFSEQ: accession NM_011203.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 775) AUTHORS Charest,A., Wagner,J., Shen,S.H. and Tremblay,M.L. TITLE Murine protein tyrosine phosphatase-PEST, a stable cytosolic protein tyrosine phosphatase JOURNAL Biochem. J. 308 (Pt 2), 425-432 (1995) MEDLINE 95289971 REFERENCE 2 (residues 1 to 775) AUTHORS den Hertog,J., Pals,C.E., Jonk,L.J. and Kruijer,W. TITLE Differential expression of a novel murine non-receptor protein tyrosine phosphatase during differentiation of P19 embryonal carcinoma cells JOURNAL Biochem. Biophys. Res. Commun. 184 (3), 1241-1249 (1992) MEDLINE 92272714 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X86781.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302143076| COMMENT VNTNAME|mPEST_D1 (NP_035333) Ptpn12| COMMENT VNTAUTHORNAME|JNA| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..288 /organism="Mus musculus" /strain="BALB/c" /db_xref="taxon:10090" /chromosome="5" /map="region A3-B" /clone_lib="Lambda Zap II" /dev_stage="17.5 days" /vntifkey="269" Protein 1..288 /product="protein tyrosine phosphatase, non-receptor type 12" /vntifkey="270" Region 21..288 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 rrfiqrvqam kspdhngedn fardfmrlrr lstkyrteki yptatgekee nvkknrykdi 61 lpfdhsrvkl tlktpsqdsd yinanfikgv ygpkayvatq gpfrntvidf wrmiweynvv 121 mivmacrefe mgrkkceryw plygedpitf apfkiscene qartdyfirt lllefqnesr 181 rlyqfhyvnw pdhdvpssfd sildmislmr kyqehedvpi cihcsagcgr tgaicaidyt 241 wnllkagkip eefnvfnliq emrtqrhsav qtkeqyelvh raiaqlfe // LOCUS mPTP1B_D1\ 279 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 1 [Mus musculus]. ACCESSION NP_035331 DBSOURCE REFSEQ: accession NM_011201.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 432) AUTHORS Haj,F.G., Markova,B., Klaman,L.D., Bohmer,F.D. and Neel,B.G. TITLE Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatase-1B JOURNAL J. Biol. Chem. 278 (2), 739-744 (2003) MEDLINE 22401841 REMARK GeneRIF: Protein tyrosine phosphatase-1B regulates receptor tyrosine kinase signaling. REFERENCE 2 (residues 1 to 432) AUTHORS Zinker,B.A., Rondinone,C.M., Trevillyan,J.M., Gum,R.J., Clampit,J.E., Waring,J.F., Xie,N., Wilcox,D., Jacobson,P., Frost,L., Kroeger,P.E., Reilly,R.M., Koterski,S., Opgenorth,T.J., Ulrich,R.G., Crosby,S., Butler,M., Murray,S.F., McKay,R.A., Bhanot,S., Monia,B.P. and Jirousek,M.R. TITLE PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (17), 11357-11362 (2002) MEDLINE 22177164 REMARK GeneRIF: findings suggest that PTP1B modulates insulin signaling in liver and fat, and that therapeutic modalities targeting PTP1B inhibition may have clinical benefit in type 2 diabetes REFERENCE 3 (residues 1 to 432) AUTHORS Rondinone,C.M., Trevillyan,J.M., Clampit,J., Gum,R.J., Berg,C., Kroeger,P., Frost,L., Zinker,B.A., Reilly,R., Ulrich,R., Butler,M., Monia,B.P., Jirousek,M.R. and Waring,J.F. TITLE Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis JOURNAL Diabetes 51 (8), 2405-2411 (2002) MEDLINE 22139929 REMARK GeneRIF: reduction regulates adiposity and expression of genes involved in lipogenesis REFERENCE 4 (residues 1 to 432) AUTHORS Iversen,L.F., Moller,K.B., Pedersen,A.K., Peters,G.H., Petersen,A.S., Andersen,H.S., Branner,S., Mortensen,S.B. and Moller,N.P. TITLE Structure determination of T cell protein-tyrosine phosphatase JOURNAL J. Biol. Chem. 277 (22), 19982-19990 (2002) MEDLINE 22028072 REMARK GeneRIF: Structure determination of T cell protein-tyrosine phosphatase REFERENCE 5 (residues 1 to 432) AUTHORS Cheng,A., Uetani,N., Simoncic,P.D., Chaubey,V.P., Lee-Loy,A., McGlade,C.J., Kennedy,B.P. and Tremblay,M.L. TITLE Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B JOURNAL Dev. Cell 2 (4), 497-503 (2002) MEDLINE 21966114 REMARK GeneRIF: Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B. REFERENCE 6 (residues 1 to 432) AUTHORS Zabolotny,J.M., Bence-Hanulec,K.K., Stricker-Krongrad,A., Haj,F., Wang,Y., Minokoshi,Y., Kim,Y.B., Elmquist,J.K., Tartaglia,L.A., Kahn,B.B. and Neel,B.G. TITLE PTP1B regulates leptin signal transduction in vivo JOURNAL Dev. Cell 2 (4), 489-495 (2002) MEDLINE 21966113 REMARK GeneRIF: PTP1B regulates leptin signal transduction REFERENCE 7 (residues 1 to 432) AUTHORS Buckley,D.A., Cheng,A., Kiely,P.A., Tremblay,M.L. and O'Connor,R. TITLE Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts JOURNAL Mol. Cell. Biol. 22 (7), 1998-2010 (2002) MEDLINE 21881935 REMARK GeneRIF: Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts REFERENCE 8 (residues 1 to 432) AUTHORS Park,K.S., Kim,Y.W., Kim,C.W., Kang,D.O. and Byun,S.M. TITLE Molecular cloning and expression of a cDNA encoding a protein tyrosine phosphatase from mouse brain JOURNAL Biochem. Mol. Biol. Int. 40 (5), 1025-1032 (1996) MEDLINE 97114074 REFERENCE 9 (residues 1 to 432) AUTHORS Hendriks,W., Schepens,J., Brugman,C., Zeeuwen,P. and Wieringa,B. TITLE A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain JOURNAL Biochem. J. 305 (Pt 2), 499-504 (1995) MEDLINE 95134232 REFERENCE 10 (residues 1 to 432) AUTHORS Miyasaka,H. and Li,S.S. TITLE The cDNA cloning, nucleotide sequence and expression of an intracellular protein tyrosine phosphatase from mouse testis JOURNAL Biochem. Biophys. Res. Commun. 185 (3), 818-825 (1992) MEDLINE 92328784 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U24700.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302141893| COMMENT VNTNAME|mPTP1B_D1 (NP_035331) Ptpn1| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..279 /organism="Mus musculus" /db_xref="taxon:10090" /chromosome="2" /tissue_type="brain" /dev_stage="adult" /vntifkey="269" Protein 1..279 /product="protein tyrosine phosphatase, non-receptor type 1" /vntifkey="270" Region 3..279 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 memekefeei dkagnwaaiy qdirheasdf pckvaklpkn knrnryrdvs pfdhsriklh 61 qedndyinas likmeeaqrs yiltqgplpn tcghfwemvw eqksrgvvml nrimekgslk 121 caqywpqqee kemvfddtgl kltlisedvk syytvrqlel enlttketre ilhfhyttwp 181 dfgvpespas flnflfkvre sgslslehgp ivvhcsagig rsgtfcladt clllmdkrkd 241 pssvdikkvl lemrrfrmgl iqtadqlrfs ylaviegak // LOCUS mPTP36_D1\ 292 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 14 [Mus musculus]. ACCESSION NP_033002 DBSOURCE REFSEQ: accession NM_008976.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 1189) AUTHORS Aoyama,K., Matsuda,T. and Aoki,N. TITLE Characterization of newly identified four isoforms for a putative cytosolic protein tyrosine phosphatase PTP36 JOURNAL Biochem. Biophys. Res. Commun. 266 (2), 523-531 (1999) MEDLINE 20068798 REFERENCE 2 (residues 1 to 1189) AUTHORS Sawada,M., Ogata,M., Fujino,Y. and Hamaoka,T. TITLE cDNA cloning of a novel protein tyrosine phosphatase with homology to cytoskeletal protein 4.1 and its expression in T-lineage cells JOURNAL Biochem. Biophys. Res. Commun. 203 (1), 479-484 (1994) MEDLINE 94354845 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D31842.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302142963| COMMENT VNTNAME|mPTP36_D1 (NP_033002) Ptpn14| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..292 /organism="Mus musculus" /strain="C.B17-scid" /db_xref="taxon:10090" /chromosome="1" /tissue_type="thymus" /clone_lib="lambda gt10" /dev_stage="adult" /vntifkey="269" Protein 1..292 /product="protein tyrosine phosphatase, non-receptor type 14" /vntifkey="270" Region 18..292 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_2 /note="PTPc" ORIGIN 1 vpiderlral kkkledgmvf teyeqipnkk angvfstatl penaersrir evvpyeenrv 61 eliptkennt gyinashikv vvggsewhyi atqgplphtc hdfwqmvweq gvnviamvta 121 eeeggrtksh rywpklgskh ssatygkfkv ttkfrtdsgc yattglkvkh llsgqertvw 181 hlqytdwphh gcpedvqgfl syleeiqsvr rhtnsvlegi rtrhppivvh csagvgrtgv 241 vilselmiyc lehnekvevp tmlrflreqr mfmiqtiaqy kfvyqvlvqf lq // LOCUS mPTPalpha_ 280 aa 27-JUN-2003 DEFINITION protein tyrosin phosphatase receptor type alpha [Mus musculus]. ACCESSION AAK56109 DBSOURCE accession AF332081.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 793) AUTHORS Ehringer,M.A., Thompson,J., Conroy,O., Xu,Y., Yang,F., Canniff,J., Beeson,M., Gordon,L., Bennett,B., Johnson,T.E. and Sikela,J.M. TITLE High-throughput sequence identification of gene coding variants within alcohol-related QTLs JOURNAL Mamm. Genome 12 (8), 657-663 (2001) MEDLINE 21363810 REFERENCE 2 (residues 1 to 793) AUTHORS Ehringer,M.A., Thompson,J., Conroy,O., Xu,Y., Yang,F., Canniff,J., Beeson,M., Gordon,L., Bennett,B., Johnson,T.E. and Sikela,J.M. TITLE Direct Submission JOURNAL Submitted (26-DEC-2000) Pharmacology, University of Colorado Health Sciences Center, 4200 East Ninth Ave C236, Denver, CO 80262, USA COMMENT Method: conceptual translation. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|306541430| COMMENT VNTNAME|mPTPalpha_D1 (AAK56109) Ptpra| COMMENT VNTAUTHORNAME|JNA| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|UNKNOWN| FEATURES Location/Qualifiers source 1..280 /organism="Mus musculus" /strain="ISS" /db_xref="taxon:10090" /vntifkey="269" Protein 1..280 /product="protein tyrosin phosphatase receptor type alpha" /vntifkey="270" ORIGIN 1 dkleeeinrr maddnklfre efnalpacpi qatceaaske enkeknryvn ilpydhsrvh 61 ltpvegvpds dyinasfing yqeknkfiaa qgpkeetvnd fwrmiweqnt ativmvtnlk 121 erkeckcaqy wpdqgcwtyg nvrvsvedvt vlvdytvrkf ciqqvgdvtn rkpqrlitqf 181 hftswpdfgv pftpigmlkf lkkvkacnpq yagaivvhcs agvgrtgtfv vidamldmmh 241 serkvdvygf vsriraqrcq mvqtdmqyvf iyqallehyl // LOCUS mPTPbeta_D 280 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, B; vascular endothelial protein tyrosine phosphatase [Mus musculus]. ACCESSION NP_084204 DBSOURCE REFSEQ: accession NM_029928.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 1998) AUTHORS Nawroth,R., Poell,G., Ranft,A., Kloep,S., Samulowitz,U., Fachinger,G., Golding,M., Shima,D.T., Deutsch,U. and Vestweber,D. TITLE VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts JOURNAL EMBO J. 21 (18), 4885-4895 (2002) MEDLINE 22220060 REMARK GeneRIF: Data show that vascular endothelial protein tyrosine phosphatase (VE-PTP) is a transmembrane binding partner of VE-cadherin that reduces the tyrosine phosphorylation of VE-cadherin and cell layer permeability. REFERENCE 2 (residues 1 to 1998) AUTHORS Hendriks,W., Schepens,J., Brugman,C., Zeeuwen,P. and Wieringa,B. TITLE A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain JOURNAL Biochem. J. 305 (Pt 2), 499-504 (1995) MEDLINE 95134232 REFERENCE 3 (residues 1 to 1998) AUTHORS Schepens,J., Zeeuwen,P., Wieringa,B. and Hendriks,W. TITLE Identification and typing of members of the protein-tyrosine phosphatase gene family expressed in mouse brain JOURNAL Mol. Biol. Rep. 16 (4), 241-248 (1992) MEDLINE 93086603 REFERENCE 4 (residues 1 to 1998) AUTHORS Gebbink,M.F., van Etten,I., Hateboer,G., Suijkerbuijk,R., Beijersbergen,R.L., Geurts van Kessel,A. and Moolenaar,W.H. TITLE Cloning, expression and chromosomal localization of a new putative receptor-like protein tyrosine phosphatase JOURNAL FEBS Lett. 290 (1-2), 123-130 (1991) MEDLINE 92008644 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY077755.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302133158| COMMENT VNTNAME|mPTPbeta_D1 (NP_084204) Ptprb| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..280 /organism="Mus musculus" /strain="Swiss Webster" /db_xref="taxon:10090" /chromosome="10" /map="5 58.0 cM" /vntifkey="269" Protein 1..280 /product="protein tyrosine phosphatase, receptor type, B" /vntifkey="270" /note="vascular endothelial protein tyrosine phosphatase" Region 17..280 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 nqfeghfmkl qadsnyllsk eyedlkdvgr sqscdiallp enrgknrynn ilpydasrvk 61 lsnvdddpcs dyinasyipg nnfrreyiat qgplpgtkdd fwkmaweqnv hnivmvtqcv 121 ekgrvkcdhy wpadqdplyy gdlilqmvse svlpewtire fkicseeqld ahrlirhfhy 181 tvwpdhgvpe ttqsliqfvr tvrdyinrsp gagptvvhcs agvgrtgtfv aldrilqqld 241 skdsvdiyga vhdlrlhrvh mvqtecqyvy lhqcvrdvlr // LOCUS mPTPBL_D1\ 275 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 13 [Mus musculus]. ACCESSION NP_035334 DBSOURCE REFSEQ: accession NM_011204.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 2460) AUTHORS Palmer,A., Zimmer,M., Erdmann,K.S., Eulenburg,V., Porthin,A., Heumann,R., Deutsch,U. and Klein,R. TITLE EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase JOURNAL Mol. Cell 9 (4), 725-737 (2002) MEDLINE 21980164 REMARK GeneRIF: With delayed kinetics, ephrinB ligands recruit the cytoplasmic PDZ domain containing protein tyrosine phosphatase PTP-BL and are dephosphorylated. REFERENCE 2 (residues 1 to 2460) AUTHORS Walma,T., Spronk,C.A., Tessari,M., Aelen,J., Schepens,J., Hendriks,W. and Vuister,G.W. TITLE Structure, dynamics and binding characteristics of the second PDZ domain of PTP-BL JOURNAL J. Mol. Biol. 316 (5), 1101-1110 (2002) MEDLINE 21881810 REMARK GeneRIF: Structure, dynamics and binding characteristics of the second PDZ domain of PTP-BL REFERENCE 3 (residues 1 to 2460) AUTHORS Hendriks,W., Schepens,J., Bachner,D., Rijss,J., Zeeuwen,P., Zechner,U., Hameister,H. and Wieringa,B. TITLE Molecular cloning of a mouse epithelial protein-tyrosine phosphatase with similarities to submembranous proteins JOURNAL J. Cell. Biochem. 59 (4), 418-430 (1995) MEDLINE 96340953 REFERENCE 4 (residues 1 to 2460) AUTHORS Chida,D., Kume,T., Mukouyama,Y., Tabata,S., Nomura,N., Thomas,M.L., Watanabe,T. and Oishi,M. TITLE Characterization of a protein tyrosine phosphatase (RIP) expressed at a very early stage of differentiation in both mouse erythroleukemia and embryonal carcinoma cells JOURNAL FEBS Lett. 358 (3), 233-239 (1995) MEDLINE 95145716 REFERENCE 5 (residues 1 to 2460) AUTHORS Hendriks,W., Schepens,J., Brugman,C., Zeeuwen,P. and Wieringa,B. TITLE A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain JOURNAL Biochem. J. 305 (Pt 2), 499-504 (1995) MEDLINE 95134232 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from Z32740.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302143017| COMMENT VNTNAME|mPTPBL_D1 (NP_035334) Ptpn13| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..275 /organism="Mus musculus" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="5" /map="5 56.0 cM" /clone="mPTP14-2" /sex="Female" /tissue_type="whole skin" /clone_lib="cDNA library in UniZap (Stratagene)" /dev_stage="post natal day 11" /vntifkey="269" Protein 1..275 /product="protein tyrosine phosphatase, non-receptor type 13" /function="phosphotyrosine dephosphorylation" /vntifkey="270" Region 20..274 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_2 /note="PTPc" ORIGIN 1 tqlqatirtl qglldqgips kelenlqelk pldqcligqt kenrrknryk nilpydttrv 61 plgdeggyin asfiripvgt qefvyiacqg plpttvgdfw qmvweqnstv iammtqeveg 121 ekikcqrywp silgtttman erlrlallrm qqlkgfivrv malediqtge vrhishlnft 181 awpdhdtpsq pddlltfisy mrhirrsgpv ithcsagigr sgtlicidvv lglisqdlef 241 disdlvrcmr lqrhgmvqte gqyvfcyqvi lyvlt // LOCUS mPTPdelta_ 273 aa 17-MAY-2003 DEFINITION protein-tyrosine-phosphatase (EC 3.1.3.48), receptor type delta, splice form D precursor - mouse. ACCESSION D54689 DBSOURCE pir: locus D54689; summary: #length 1691 #molecular-weight 190175 #checksum 4705 ; includes: protein tyrosine phosphatase, receptor type delta, splice form A ; superfamily: leukocyte antigen-related protein; fibronectin type III repeat homology; immunoglobulin homology; leukocyte common antigen cytosolic domain homology; protein-tyrosine-phosphatase homology ; PIR dates: 10-Sep-1999 #sequence_revision 10-Sep-1999 #text_change 10-Sep-1999 . KEYWORDS alternative splicing; glycoprotein; phosphoprotein; phosphoric monoester hydrolase; transmembrane protein; tyrosine-specific phosphatase. SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 1691) AUTHORS Mizuno,K., Hasegawa,K., Katagiri,T., Ogimoto,M., Ichikawa,T. and Yakura,H. TITLE MPTP delta, a putative murine homolog of HPTP delta, is expressed in specialized regions of the brain and in the B-cell lineage JOURNAL Mol. Cell. Biol. 13 (9), 5513-5523 (1993) MEDLINE 93360986 COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302132575| COMMENT VNTNAME|mPTPdelta_D1 (D54689) Ptprd| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..273 /organism="Mus musculus" /db_xref="taxon:10090" /vntifkey="269" Protein 1..273 /product="protein-tyrosine-phosphatase, receptor type delta, splice form D precursor" /EC_number="3.1.3.48" /vntifkey="270" /note="MPTP delta type D" Region 1..273 /region_name="domain" /vntifkey="1000" /label=LAC /note="leukocyte common antigen cytosolic domain homology #label LAC" Site 212..212 /site_type="active" /vntifkey="220" /label=Active_Site_1 /note="Cys (phosphocysteine intermediate)" Site 218..218 /site_type="binding" /vntifkey="1007" /label=Binding_1 /note="substrate phosphate (Arg)" ORIGIN 1 leladhierl kandnlkfsq eyesidpgqq ftwehsnlev nkpknryanv iaydhsrvll 61 saiegipgsd yvnanyidgy rkqnayiatq gslpetfgdf wrmiweqeat vvmmtkleer 121 srvkcdqywp srgtethglv qvtlldtvel tycvrtfaly nngssekrkv rqfqftawpd 181 hgvpehptpf laflrrvktc nppdagpmvv hcsagvgrtg cfividamle rikhektvdi 241 yghvtlmraq rnymvqtedq yifihdalle avt // LOCUS mPTPepsilo 279 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, E [Mus musculus]. ACCESSION NP_035342 DBSOURCE REFSEQ: accession NM_011212.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 699) AUTHORS Schmidt,A., Rutledge,S.J., Endo,N., Opas,E.E., Tanaka,H., Wesolowski,G., Leu,C.T., Huang,Z., Ramachandaran,C., Rodan,S.B. and Rodan,G.A. TITLE Protein-tyrosine phosphatase activity regulates osteoclast formation and function: inhibition by alendronate JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (7), 3068-3073 (1996) MEDLINE 96181534 REFERENCE 2 (residues 1 to 699) AUTHORS Elson,A. and Leder,P. TITLE Identification of a cytoplasmic, phorbol ester-inducible isoform of protein tyrosine phosphatase epsilon JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (26), 12235-12239 (1995) MEDLINE 96109240 REFERENCE 3 (residues 1 to 699) AUTHORS Elson,A. and Leder,P. TITLE Protein-tyrosine phosphatase epsilon. An isoform specifically expressed in mouse mammary tumors initiated by v-Ha-ras OR neu JOURNAL J. Biol. Chem. 270 (44), 26116-26122 (1995) MEDLINE 96064677 REFERENCE 4 (residues 1 to 699) AUTHORS Hendriks,W., Schepens,J., Brugman,C., Zeeuwen,P. and Wieringa,B. TITLE A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain JOURNAL Biochem. J. 305 (Pt 2), 499-504 (1995) MEDLINE 95134232 REFERENCE 5 (residues 1 to 699) AUTHORS Schepens,J., Zeeuwen,P., Wieringa,B. and Hendriks,W. TITLE Identification and typing of members of the protein-tyrosine phosphatase gene family expressed in mouse brain JOURNAL Mol. Biol. Rep. 16 (4), 241-248 (1992) MEDLINE 93086603 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U62387.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302142852| COMMENT VNTNAME|mPTPepsilon_D1 (NP_035342) Ptpre| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..279 /organism="Mus musculus" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="7" /map="7 67.6 cM" /clone="cd-1" /tissue_type="brain and lung" /vntifkey="269" Protein 1..279 /product="protein tyrosine phosphatase, receptor type, E" /vntifkey="270" Region 18..279 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 ehleeeirvr saddckrfre efnslpsghi qgtfelanke enreknrypn ilpndhcrvi 61 lsqvdgipcs dyinasyidg ykeknkfiaa qgpkqetvnd fwrmvweqrs ativmltnlk 121 erkeekcyqy wpdqgcwtyg nirvcvedcv vlvdytirkf cihpqlpdsc kaprlvsqlh 181 ftswpdfgvp ftpigmlkfl kkvktlnpsh agpivvhcsa gvgrtgtfiv idammdmihs 241 eqkvdvfefv srirnqrpqm vqtdvqytfi yqalleyyl // LOCUS mPTPESP_D1 279 aa 17-MAY-2003 DEFINITION embryonic stem cell phosphatase; protein tyrosine phosphatase, receptor type, W [Mus musculus]. ACCESSION NP_031981 DBSOURCE REFSEQ: accession NM_007955.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 1705) AUTHORS Morrison,D.F. and Mauro,L.J. TITLE Structural characterization and chromosomal localization of the mouse cDNA and gene encoding the bone tyrosine phosphatase, mOST-PTP JOURNAL Gene 257 (2), 195-208 (2000) MEDLINE 20534790 REFERENCE 2 (residues 1 to 1705) AUTHORS Lee,K., Nichols,J. and Smith,A. TITLE Identification of a developmentally regulated protein tyrosine phosphatase in embryonic stem cells that is a marker of pluripotential epiblast and early mesoderm JOURNAL Mech. Dev. 59 (2), 153-164 (1996) MEDLINE 97109513 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U36488.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302133369| COMMENT VNTNAME|mPTPESP_D1 (NP_031981) Ptprv| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..279 /organism="Mus musculus" /db_xref="taxon:10090" /chromosome="1" /cell_line="ES cell line D3" /vntifkey="269" Protein 1..279 /product="embryonic stem cell phosphatase" /vntifkey="270" /note="protein tyrosine phosphatase, receptor type, W" Protein 1..279 /product="embryonic stem cell phosphatase" /vntifkey="270" /note="putative; protein tyrosine phosphatase, receptor type, W" Region 18..279 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 hsfrqsyeak sarahqaffq efeelkevgk dqprleaehp anitknryph vlpydhsrvr 61 ltqlsgephs dyinanfipg yshpqeiiat qgplkktved fwrlvweqqv hviimltvgm 121 engrvlcehy wpvnstpvth ghitthllae esedewtrre fqlqhgaeqk qrrvkqlqft 181 twpdhsvpea pssllafvel vqeevkatqg kgpilvhcsa gvgrtgtfva llpavrqlee 241 eqvvdvfntv yilrlhrplm iqtlsqyifl hscllnkil // LOCUS mPTPgamma_ 291 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, G [Mus musculus]. ACCESSION NP_033007 DBSOURCE REFSEQ: accession NM_008981.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 1442) AUTHORS Barnea,G., Silvennoinen,O., Shaanan,B., Honegger,A.M., Canoll,P.D., D'Eustachio,P., Morse,B., Levy,J.B., Laforgia,S., Huebner,K. et al. TITLE Identification of a carbonic anhydrase-like domain in the extracellular region of RPTP gamma defines a new subfamily of receptor tyrosine phosphatases JOURNAL Mol. Cell. Biol. 13 (3), 1497-1506 (1993) MEDLINE 93180796 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L09562.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302132875| COMMENT VNTNAME|mPTPgamma_D1 (NP_033007) Ptprg| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..291 /organism="Mus musculus" /db_xref="taxon:10090" /chromosome="14" /map="14 2.0 cM" /tissue_type="brain" /dev_stage="adult" /vntifkey="269" Protein 1..291 /product="protein tyrosine phosphatase, receptor type, G" /vntifkey="270" Region 17..291 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_2 /note="PTPc" ORIGIN 1 kqfgkhigel ysnsqhgfse dfeevqrcta dmnitaehsn hpdnkhknry inilaydhsr 61 vklrplpgkd skhsdyinan yvdgynkaka yiatqgplks tfedfwrmiw eqntgiiimi 121 tnlvekgrrk cdqywptent eeygniivtl kstkvhacyt vrrlsvrntk vkkgqkgnpk 181 grqnertviq yhytqwpdmg vpeyalpvlt fvrrssaarm pdmgpvlvhc sagvgrtgty 241 ividsmlqqi kdkstvnvlg flkhirtqrn ylvqteeqyi fihdalleai l // LOCUS mPTPH1_D1\ 276 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 3 [Mus musculus]. ACCESSION XP_143789 DBSOURCE REFSEQ: accession XM_143789.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 1028) AUTHORS NCBI Annotation Project. TITLE Direct Submission JOURNAL Submitted (15-MAY-2002) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA COMMENT GENOME ANNOTATION REFSEQ: This model reference sequence was predicted from NCBI contig NW_000208 by automated computational analysis using gene prediction method: GenomeScan, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302142662| COMMENT VNTNAME|mPTPH1_D1 (XP_143789) Ptpn3| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..276 /organism="Mus musculus" /strain="C57BL/6J" /db_xref="taxon:10090" /chromosome="4" /vntifkey="269" Protein 1..276 /product="protein tyrosine phosphatase, non-receptor type 3" /vntifkey="270" Region 22..276 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_2 /note="PTPc" Region 43..272 /region_name="Protein-tyrosine phosphatase" /db_xref="CDD:pfam00102" /vntifkey="266" /label=Region_3 /note="Y_phosphatase" Region 133..269 /region_name="Dual specificity phosphatase, catalytic domain" /db_xref="CDD:pfam00782" /vntifkey="266" /label=Region_4 /note="DSPc" Region 173..272 /region_name="Protein tyrosine phosphatase, catalytic domain motif" /db_xref="CDD:smart00404" /vntifkey="266" /label=Region_5 /note="PTPc_motif" Region 176..226 /region_name="Dual specificity phosphatase, catalytic domain" /db_xref="CDD:smart00195" /vntifkey="266" /label=Region_6 /note="DSPc" ORIGIN 1 dslegsmell kkglesgtvl iqfeqlyrkk pglavsfakl pqnldknryk dvlpydttrv 61 llqgnedyin asyvnmempa anlvnkyiat qgplpntcaq fwqvvwdqkl slvvmlttlt 121 ergrtkchqy wpdppdimdh gifhiqcqte dctiayvsre mlvtntetge ehtvthlqyv 181 awpdhgvpdd ssdflefvky vrslrvdgep alvhcsagig rtgvlvtmet amcliernlp 241 vypldivrkm rdqrammvqt ssqykfvcea ilrvye // LOCUS mPTPK1_D1\ 288 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 18 [Mus musculus]. ACCESSION NP_035336 DBSOURCE REFSEQ: accession NM_011206.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 452) AUTHORS Dosil,M., Leibman,N. and Lemischka,I.R. TITLE Cloning and characterization of fetal liver phosphatase 1, a nuclear protein tyrosine phosphatase isolated from hematopoietic stem cells JOURNAL Blood 88 (12), 4510-4525 (1996) MEDLINE 97131769 REFERENCE 2 (residues 1 to 452) AUTHORS Huang,K., Sommers,C.L., Grinberg,A., Kozak,C.A. and Love,P.E. TITLE Cloning and characterization of PTP-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrow JOURNAL Oncogene 13 (7), 1567-1573 (1996) MEDLINE 97030045 REFERENCE 3 (residues 1 to 452) AUTHORS Cheng,J., Daimaru,L., Fennie,C. and Lasky,L.A. TITLE A novel protein tyrosine phosphatase expressed in lin(lo)CD34(hi)Sca(hi) hematopoietic progenitor cells JOURNAL Blood 88 (4), 1156-1167 (1996) MEDLINE 96329547 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U52523.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302143252| COMMENT VNTNAME|mPTPK1_D1 (NP_035336) Ptpn18| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..288 /organism="Mus musculus" /db_xref="taxon:10090" /chromosome="1" /map="1 17.3 cM" /cell_type="fetal liver hematopoietic stem cells" /vntifkey="269" Protein 1..288 /product="protein tyrosine phosphatase, non-receptor type 18" /vntifkey="270" Region 21..288 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 dlvrslleql eardyregai larefsdika rsvawksegv cstkagsrlg ntnknrykdv 61 vaydetrvil sllqeeghgd yinanfirgi dgsqayiatq gplphtlldf wrlvwefgvk 121 vilmacqete ngrrkceryw areqeplkag pfcitltket tlnaditlrt lqvtfqkefr 181 svhqlqymsw pdhgvpsssd hiltmveear clqglgpgpl cvhcsagcgr tgvlcavdyv 241 rqllltqtip pnfslfqvvl emrkqrpaav qteeqyrfly htvaqlfs // LOCUS mPTPkappa_ 274 aa 30-JUN-2003 DEFINITION protein tyrosine phosphatase, receptor type, K [Mus musculus]. ACCESSION NP_033009 DBSOURCE REFSEQ: accession NM_008983.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 1457) AUTHORS Jiang,Y.P., Wang,H., D'Eustachio,P., Musacchio,J.M., Schlessinger,J. and Sap,J. TITLE Cloning and characterization of R-PTP-kappa, a new member of the receptor protein tyrosine phosphatase family with a proteolytically cleaved cellular adhesion molecule-like extracellular region JOURNAL Mol. Cell. Biol. 13 (5), 2942-2951 (1993) MEDLINE 93233655 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L10106.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|306792690| COMMENT VNTNAME|mPTPkappa_D1 (NP_033009 (revised)) Ptprk| COMMENT VNTAUTHORNAME|JNA| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..274 /organism="Mus musculus" /db_xref="taxon:10090" /chromosome="10" /map="10 19.0 cM" /tissue_type="brain" /tissue_lib="lambda gt11" /vntifkey="269" Protein 1..274 /product="protein tyrosine phosphatase, receptor type, K" /vntifkey="270" Region 1..274 /product="protein tyrosine phosphatase, receptor type, K" /vntifkey="203" /label=Chain_1 Region 17..274 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_2 /note="PTPc" ORIGIN 1 adllqhinlm ktsdsygfke eyesffegqs aswdvakkdq nraknrygni iaydhsrvil 61 qpveddpssd yinanyrdgy qrpshyiatq gpvhetvydf wrmvwqeqsa civmvtnlve 121 vgrvkcykyw pddtevygdf kvtcvemepl aeyvvrtftl errgyneire vkqfhftgwp 181 dhgvpyhatg llsfirrvkl snppsagpiv vhcsagagrt gcyividiml dmaeregvvd 241 iyncvkalrs rrinmvqtee qyifihdail eacl // LOCUS mPTPlamda_ 270 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, L [Mus musculus]. ACCESSION NP_035344 DBSOURCE REFSEQ: accession NM_011214.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 1436) AUTHORS Yoneya,T., Yamada,Y., Kakeda,M., Osawa,M., Arai,E., Hayashi,K., Nishi,N., Inoue,H. and Nishikawa,M. TITLE Molecular cloning of a novel receptor-type protein tyrosine phosphatase from murine fetal liver JOURNAL Gene 194 (2), 241-247 (1997) MEDLINE 97417493 REFERENCE 2 (residues 1 to 1436) AUTHORS Cheng,J., Armanini,M., Phillips,H., Dowbenko,D., Daimaru,L. and Lasky,L.A. TITLE A novel protein tyrosine phosphatase related to the homotypically adhering Kappa and Mu receptors JOURNAL Unpublished COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U55057.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302132458| COMMENT VNTNAME|mPTPlamda_D1 (NP_035344) Ptprl| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..270 /organism="Mus musculus" /db_xref="taxon:10090" /chromosome="4" /tissue_type="lung" /dev_stage="10 day embryo" /vntifkey="269" Protein 1..270 /product="protein tyrosine phosphatase, receptor type, L" /vntifkey="270" Region 17..270 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_2 /note="PTPc" ORIGIN 1 adllqhinqm ktaegygfkq eyesffegwd atkkkdklkg grqepvsayd rhhvklhpml 61 adpdadyisa nyidgyhrsn hfiatqgpkp emiydfwrmv wqeqcasivm itklvevgrv 121 kcsrywpeds dmygdikitl vktetlaeyv vrtfalerrg ysarhevrqf hftawpehgv 181 pyhatgllaf irrvkastpp dagpivihcs agtgrtgcyi vldvmldmae cegvvdiync 241 vktlcsrrvn miqteeqyif ihdaileacl // LOCUS mPTPmu_D1\ 274 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, M; protein tyrosine phosphatase, receptor-type, M [Mus musculus]. ACCESSION NP_033010 DBSOURCE REFSEQ: accession NM_008984.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 AUTHORS Gebbink,M.F., van Etten,I., Hateboer,G., Suijkerbuijk,R., Beijersbergen,R.L., Geurts van Kessel,A. and Moolenaar,W.H. TITLE Cloning, expression and chromosomal localization of a new putative receptor-like protein tyrosine phosphatase JOURNAL FEBS Lett. 290 (1-2), 123-130 (1991) MEDLINE 92008644 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X58287.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302132357| COMMENT VNTNAME|mPTPmu_D1 (NP_033010) Ptprm| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..274 /organism="Mus musculus" /db_xref="taxon:10090" /chromosome="17" /map="17 38.3 cM" /clone="GH3, GH15, GH4" /tissue_type="lung" /clone_lib="lambda ZAP" /vntifkey="269" Protein 1..274 /product="protein tyrosine phosphatase, receptor type, M" /vntifkey="270" /note="protein tyrosine phosphatase, receptor-type, M" Region 1..274 /product="protein tyrosine phosphatase, receptor type, M" /EC_number="3.1.3.48" /vntifkey="203" /label=Chain_1 Region 17..274 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_2 /note="PTPc" ORIGIN 1 adllqhitqm kcaegygfke eyesffegqs apwdsakkde nrmknrygni iaydhsrvrl 61 qmlegdnnsd yingnyidgy hrpnhyiatq gpmqetiydf wrmvwhenta siimvtnlve 121 vgrvkcckyw pddteiykdi kvtlidtell aeyvirtfav ekrgiheire irqfhftgwp 181 dhgvpyhatg llgfvrqvks ksppnagplv vhcsagagrt gcfividiml dmaeregvvd 241 iyncvrelrs rrvnmvqtee qyvfihdail eacl // LOCUS mPTPNP_D1\ 279 aa 17-MAY-2003 DEFINITION Protein-tyrosine phosphatase X precursor (R-PTP-X) (PTP IA-2beta) (Protein tyrosine phosphatase-NP) (PTP-NP). ACCESSION P80560 DBSOURCE swissprot: locus PTPX_MOUSE, accession P80560; class: standard. extra accessions:O09134,P70328,created: Nov 1, 1997. sequence updated: Nov 1, 1997. annotation updated: Sep 15, 2003. xrefs: gi: 1515424, gi: 1515425, gi: 1769593, gi: 1769594 xrefs (non-sequence databases): HSSPP18052, MGDMGI:107418, InterProIPR000387, InterProIPR000242, PfamPF00102, PRINTSPR00700, SMARTSM00194, PROSITEPS00383, PROSITEPS50056, PROSITEPS50055 KEYWORDS Hydrolase; Receptor; Glycoprotein; Signal; Transmembrane; Alternative splicing. SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 1001) AUTHORS Chiang,M.K. and Flanagan,J.G. TITLE PTP-NP, a new member of the receptor protein tyrosine phosphatase family, implicated in development of nervous system and pancreatic endocrine cells JOURNAL Development 122 (7), 2239-2250 (1996) MEDLINE 96281667 REMARK SEQUENCE FROM N.A. STRAIN=ICR; TISSUE=Brain REFERENCE 2 (residues 1 to 1001) AUTHORS Lu,J., Li,Q., Xie,H., Chen,Z.J., Borovitskaya,A.E., Maclaren,N.K., Notkins,A.L. and Lan,M.S. TITLE Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (6), 2307-2311 (1996) MEDLINE 96197307 REMARK SEQUENCE OF 282-1001 FROM N.A. TISSUE=Neonatal brain COMMENT ------------------------------------------------------------------- This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. The original entry is available from http://www.expasy.ch/sprot and http://www.ebi.ac.uk/sprot ------------------------------------------------------------------. [FUNCTION] IMPLICATED IN DEVELOPMENT OF NERVOUS SYSTEM AND PANCREATIC ENDOCRINE CELLS. [CATALYTIC ACTIVITY] Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. [SUBCELLULAR LOCATION] Type I membrane protein (Probable). [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist; Name=1; Synonyms=Type 1-PTP-NP; IsoId=P80560-1; Sequence=Displayed; Name=2; Synonyms=Type 2-PTP-NP; IsoId=P80560-2; Sequence=Not described. [TISSUE SPECIFICITY] PANCREAS AND BRAIN. [DEVELOPMENTAL STAGE] EXPRESSED IN EARLY STAGES OF PANCREATIC DEVELOPMENT. FIRST EXPRESSED IN DAY 8.5 EMBRYOS (E8.5) IN THE DORSAL PART OF THE MIDGUT ENDODERM AND BY E9.5, IN THE PANCREATIC RUDIMENT SPECIFICALLY IN EARLY ENDOCRINE PROGENITOR CELLS. AT LATER STAGES EXPRESSED IN INSULIN- OR GLUCAGON-PRODUCING CELLS. DURING NEURAL DEVELOPMENT, THE TYPE 2 PTP-NP IS EXPRESSED IN EARLY STAGES OF NEUROGENESIS, AND THE TYPE 1 WEAKLY IN THE LATER STAGES. [PTM] APPEARS TO UNDERGO MULTIPLE PROTEOLYTIC CLEAVAGE AT CONSECUTIVE BASIC RESIDUES (BY SIMILARITY). [DISEASE] AUTOANTIGEN IN INSULIN-DEPENDENT DIABETES MELLITUS (IDDD). [SIMILARITY] Contains 1 protein-tyrosine phosphatase domain. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302141936| COMMENT VNTNAME|mPTPNP_D1 (P80560) Ptprn2| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..279 /organism="Mus musculus" /db_xref="taxon:10090" /vntifkey="269" Protein 1..279 /gene="PTPRN2" /product="Protein-tyrosine phosphatase X precursor" /EC_number="3.1.3.48" /vntifkey="270" Region 1..279 /gene="PTPRN2" /region_name="Mature chain" /vntifkey="203" /label=PTPRN2 /note="PROTEIN-TYROSINE PHOSPHATASE X." Region 0..0 /gene="PTPRN2" /region_name="Conflict" /vntifkey="240" /label=PTPRN2 /note="H -> P (IN REF. 2)." Region 0..0 /gene="PTPRN2" /region_name="Conflict" /vntifkey="240" /label=PTPRN2 /note="I -> M (IN REF. 2)." Region 0..0 /gene="PTPRN2" /region_name="Conflict" /vntifkey="240" /label=PTPRN2 /note="S -> L (IN REF. 2)." Site 0..0 /gene="PTPRN2" /site_type="glycosylation" /vntifkey="238" /label=PTPRN2 /note="N-LINKED (GLCNAC...) (POTENTIAL)." Region 0..0 /gene="PTPRN2" /region_name="Conflict" /vntifkey="240" /label=PTPRN2 /note="L -> H (IN REF. 2)." Region 1..279 /gene="PTPRN2" /region_name="Domain" /vntifkey="1004" /label=PTPRN2 /note="CYTOPLASMIC (POTENTIAL)." Region 42..276 /gene="PTPRN2" /region_name="Domain" /vntifkey="1000" /label=PTPRN2 /note="PROTEIN-TYROSINE PHOSPHATASE." Site 0..0 /gene="PTPRN2" /site_type="active" /vntifkey="220" /label=PTPRN2 /note="POTENTIAL." ORIGIN 1 hmilaymedh lknknrleke wealcayqae pnsslvaqre enapknrsla vltydhsril 61 lksqnshgss dyinaspimd hdprnpayia tqgplpatva dfwqmvwesg cavivmltpl 121 sengvrqchh ywpdegsnly hvyevnlvse hiwcqdflvr sfylknlqtn etrtvtqfhf 181 lswydqgvps strslldfrr kvnkcyrgrs cpiivhcsdg agrsgtyvli dmvlnkmakg 241 akeidiaatl ehlrdqrpgm vqtkeqfefa ltavaeevn // LOCUS mPTPphi_D1 277 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, O [Mus musculus]. ACCESSION NP_035346 DBSOURCE REFSEQ: accession NM_011216.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 405) AUTHORS Tomemori,T., Seki,N., Suzuki,Y., Shimizu,T., Nagata,H., Konno,A. and Shirasawa,T. TITLE Isolation and characterization of murine orthologue of PTP-BK JOURNAL Biochem. Biophys. Res. Commun. 276 (3), 974-981 (2000) MEDLINE 20483617 REFERENCE 2 (residues 1 to 405) AUTHORS Wang,R., St John,P.L., Kretzler,M., Wiggins,R.C. and Abrahamson,D.R. TITLE Molecular cloning, expression, and distribution of glomerular epithelial protein 1 in developing mouse kidney JOURNAL Kidney Int. 57 (5), 1847-1859 (2000) MEDLINE 20253265 REFERENCE 3 (residues 1 to 405) AUTHORS Pixley,F.J., Lee,P.S., Dominguez,M.G., Einstein,D.B. and Stanley,E.R. TITLE A heteromorphic protein-tyrosine phosphatase, PTP phi, is regulated by CSF-1 in macrophages JOURNAL J. Biol. Chem. 270 (45), 27339-27347 (1995) MEDLINE 96070847 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U37465.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302132930| COMMENT VNTNAME|mPTPphi_D1 (NP_035346) Ptpro| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..277 /organism="Mus musculus" /strain="BALB/cxA.CA F1" /db_xref="taxon:10090" /chromosome="6" /map="4 61.0 cM" /cell_line="BAC1.2F5 - spleen-derived macrophage cell line" /vntifkey="269" Protein 1..277 /product="protein tyrosine phosphatase, receptor type, O" /vntifkey="270" Region 17..272 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 ddfdsyikdm akdsdykfsl qfeelkligl diphfaadlp lnrcknrytn ilpydfsrvr 61 lvsmneeega dyinanyipg ynspqeyiat qgplpetrnd fwkmvlqqks hiivmltqcn 121 ekrrvkcdhy wpfteepiay gditvemvse eeeedwasrh frinyadeaq dvmhfnytgw 181 pdhgvppana aesilqfvft vrqqaakskg pmiihcsagv grtgtfiald rllqhirdhe 241 fvdilglvse mrsyrmsmvq teeqyifihq cvqlmwl // LOCUS mPTPrho_D1 274 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, T [Mus musculus]. ACCESSION NP_067439 DBSOURCE REFSEQ: accession NM_021464.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 1435) AUTHORS Buchli,A.D., Zimmermann,D.R., Pfister,F. and Vaughan,L. TITLE RPTPmam4: a fourth member of the MAM family of receptor protein tyrosine phosphatases expressed in adult brain JOURNAL Unpublished COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF244125.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302132403| COMMENT VNTNAME|mPTPrho_D1 (NP_067439) Ptprt| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..274 /organism="Mus musculus" /db_xref="taxon:10090" /chromosome="2" /map="2 93.0 cM" /tissue_type="brain" /vntifkey="269" Protein 1..274 /product="protein tyrosine phosphatase, receptor type, T" /vntifkey="270" Region 17..274 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 adllqhitqm krgqgygfke eyealpegqt aswdtakede nrnknrygni isydhsrvrl 61 lvldgdphsd yinanyidgy hrprhyiatq gpmqetvkdf wrmiwqensa sivmvtnlve 121 vgrvkcvryw pddtevygdi kvtlietepl aeyvirtftv qkkgyheire lrlfhftswp 181 dhgvpcyatg llgfvrqvkf lnppeagpiv vhcsagagrt gcfiaidtml dmaenegvvd 241 ifncvrelra qrvnlvqtee qyvfvhdail eacl // LOCUS mPTPRL10_D 292 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 21 [Mus musculus]. ACCESSION NP_036007 DBSOURCE REFSEQ: accession NM_011877.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 1176) AUTHORS Higashitsuji,H., Arii,S., Furutani,M., Imamura,M., Kaneko,Y., Takenawa,J., Nakayama,H. and Fujita,J. TITLE Enhanced expression of multiple protein tyrosine phosphatases in the regenerating mouse liver: isolation of PTP-RL10, a novel cytoplasmic-type phosphatase with sequence homology to cytoskeletal protein 4.1 JOURNAL Oncogene 10 (2), 407-414 (1995) MEDLINE 95140431 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D37801.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302133979| COMMENT VNTNAME|mPTPRL10_D1 (NP_036007) Ptpn21| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..292 /organism="Mus musculus" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="12" /sex="male" /tissue_type="liver" /clone_lib="Uni-ZAP XR" /dev_stage="adult" /vntifkey="269" Protein 1..292 /product="protein tyrosine phosphatase, non-receptor type 21" /vntifkey="270" Region 18..292 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_2 /note="PTPc" ORIGIN 1 atnderckvl eqrleqgmvf teyerilkkr lvdgecstar lpenaernrf qdvlpyddar 61 velvptkenn tgyinashik vsvsgiewdy iatqgplqnt cqdfwqmvwe qgvaiiamvt 121 aeeeggreks frywprlgsr hntvtygrfk ittrfrtdsg cyattglkmk hlltgqertv 181 whlqytdwpe hgcpedlkgf lsyleeiqsv rrhtnstsep kshnppllvh csagvgrtgv 241 vilseimvac lehnevldip rvldmlrqqr mmlvqtlgqy tfvyrvliqf lk // LOCUS mPTPsigma_ 275 aa 1-JUL-2003 DEFINITION protein tyrosine phosphatase, receptor type, S [Mus musculus]. ACCESSION NP_035348 DBSOURCE REFSEQ: accession NM_011218.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 1904) AUTHORS McLean,J., Batt,J., Doering,L.C., Rotin,D. and Bain,J.R. TITLE Enhanced rate of nerve regeneration and directional errors after sciatic nerve injury in receptor protein tyrosine phosphatase sigma knock-out mice JOURNAL J. Neurosci. 22 (13), 5481-5491 (2002) MEDLINE 22092360 REMARK GeneRIF: Enhanced rate of nerve regeneration and directional errors after sciatic nerve injury in PTPsigma knockout mice REFERENCE 2 (residues 1 to 1904) AUTHORS Hendriks,W., Schepens,J., Brugman,C., Zeeuwen,P. and Wieringa,B. TITLE A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain JOURNAL Biochem. J. 305 (Pt 2), 499-504 (1995) MEDLINE 95134232 REFERENCE 3 (residues 1 to 1904) AUTHORS Wagner,J., Boerboom,D. and Tremblay,M.L. TITLE Molecular cloning and tissue-specific RNA processing of a murine receptor-type protein tyrosine phosphatase JOURNAL Eur. J. Biochem. 226 (3), 773-782 (1994) MEDLINE 95112841 REFERENCE 4 (residues 1 to 1904) AUTHORS Schepens,J., Zeeuwen,P., Wieringa,B. and Hendriks,W. TITLE Identification and typing of members of the protein-tyrosine phosphatase gene family expressed in mouse brain JOURNAL Mol. Biol. Rep. 16 (4), 241-248 (1992) MEDLINE 93086603 REFERENCE 5 (residues 1 to 1904) AUTHORS Ogata,M., Sawada,M. and Hamaoka,T. TITLE Expression of a novel murine receptor protein tyrosine phosphatase in the thymus JOURNAL Unpublished COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D28530.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|306982956| COMMENT VNTNAME|mPTPsigma_D1 (NP_035348(revised)) Ptprs| COMMENT VNTAUTHORNAME|JNA| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..275 /organism="Mus musculus" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="17" /map="17 33.8 cM" /sex="female" /tissue_type="thymus" /clone_lib="B6 and lambda gt10" /dev_stage="adult" /vntifkey="269" Protein 1..275 /product="protein tyrosine phosphatase, receptor type, S" /vntifkey="270" Region 17..274 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_4 /note="PTPc" ORIGIN 1 tdmaehmerl kandslklsq eyesidpgqq ftwehsnlea nkpknryanv iaydhsrvil 61 qplegimgsd yinanyvdgy rrqnayiatq gplpetfgdf wrmvweqrsa tvvmmtrlee 121 ksrikcdqyw pnrgtetygf iqvtlldtme latfcvrtfs lhkngssekr evrhfqftaw 181 pdhgvpeypt pflaflrrvk tcnppdagpi vvhcsagvgr tgcfividam leriktektv 241 dvyghvtlmr sqrnymvqte dqygfiheal leavg // LOCUS mPTPSL_D1\ 275 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, R; STEP-like PTPase [Mus musculus]. ACCESSION NP_035347 DBSOURCE REFSEQ: accession NM_011217.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 656) AUTHORS Ogata,M., Sawada,M., Fujino,Y. and Hamaoka,T. TITLE cDNA cloning and characterization of a novel receptor-type protein tyrosine phosphatase expressed predominantly in the brain JOURNAL J. Biol. Chem. 270 (5), 2337-2343 (1995) MEDLINE 95138207 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D31898.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302133506| COMMENT VNTNAME|mPTPSL_D1 (NP_035347) Ptprr| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..275 /organism="Mus musculus" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="10" /tissue_type="brain" /clone_lib="lambda gt10 Dr.K.Kato" /dev_stage="adult" /vntifkey="269" Protein 1..275 /product="protein tyrosine phosphatase, receptor type, R" /vntifkey="270" /note="STEP-like PTPase" Region 1..275 /product="PTPBR7" /vntifkey="203" /label=Chain_1 /note="receptor-type protein tyrosine phosphatase" Region 18..270 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 srvltrsqlr dvvasshllq sefmeipmnf vdpkeidipr hgtknrykti lpnplsrvcl 61 rpknitdsls tyinanyirg ysgkekafia tqgpmintvn dfwqmvwqed spvivmitkl 121 keknekcvly wpekrgiygk vevlvtgvte cdnytirnlv lkqgshtqhv khywytswpd 181 hktpdsaqpl lqlmldveed rlasegrgpv vvhcsagigr tgcfiatsig cqqlkeegvv 241 dalsivcqlr vdrggmvqts eqyefvhhal clfes // LOCUS mPTPTyp_D1 273 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 20 [Mus musculus]. ACCESSION NP_033004 DBSOURCE REFSEQ: accession NM_008978.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (sites) AUTHORS Ohsugi,M., Kuramochi,S., Matsuda,S. and Yamamoto,T. TITLE Molecular cloning and characterization of a novel cytoplasmic protein-tyrosine phosphatase that is specifically expressed in spermatocytes JOURNAL J. Biol. Chem. 272 (52), 33092-33099 (1997) MEDLINE 98070510 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D64141.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302142615| COMMENT VNTNAME|mPTPTyp_D1 (NP_033004) Ptpn20| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..273 /organism="Mus musculus" /db_xref="taxon:10090" /chromosome="14" /tissue_type="testis" /vntifkey="269" Protein 1..273 /product="protein tyrosine phosphatase, non-receptor type 20" /vntifkey="270" Region 18..273 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 samrdclntl qkkeeldiir efleleqmtl pddfnsgntl qnrdknryrd ilpydstrvp 61 lgknkdyina syirivnhee eyfyiatqgp lpetiedfwq mvlenncnvi amitreiecg 121 vikcysywpi slkeplefeh fsvfletfhv tqyftvrvfq ivkkstgksq cvkhlqftkw 181 pdhgtpasad ffikyvryvr kshitgpllv hcsagvgrtg vficvdvvfs aieknysfdi 241 mnivtqmrkq rcgmiqtkeq yqfcyeivle vlq // LOCUS mSAP1_D1\( 279 aa 30-JUN-2003 DEFINITION unnamed protein product [Mus musculus]. ACCESSION BAC37443 DBSOURCE accession AK078884.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 AUTHORS Carninci,P. and Hayashizaki,Y. TITLE High-efficiency full-length cDNA cloning JOURNAL Meth. Enzymol. 303, 19-44 (1999) MEDLINE 99279253 REFERENCE 2 AUTHORS Carninci,P., Shibata,Y., Hayatsu,N., Sugahara,Y., Shibata,K., Itoh,M., Konno,H., Okazaki,Y., Muramatsu,M. and Hayashizaki,Y. TITLE Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes JOURNAL Genome Res. 10 (10), 1617-1630 (2000) MEDLINE 20499374 REFERENCE 3 AUTHORS Shibata,K., Itoh,M., Aizawa,K., Nagaoka,S., Sasaki,N., Carninci,P., Konno,H., Akiyama,J., Nishi,K., Kitsunai,T., Tashiro,H., Itoh,M., Sumi,N., Ishii,Y., Nakamura,S., Hazama,M., Nishine,T., Harada,A., Yamamoto,R., Matsumoto,H., Sakaguchi,S., Ikegami,T., Kashiwagi,K., Fujiwake,S., Inoue,K., Togawa,Y., Izawa,M., Ohara,E., Watahiki,M., Yoneda,Y., Ishikawa,T., Ozawa,K., Tanaka,T., Matsuura,S., Kawai,J., Okazaki,Y., Muramatsu,M., Inoue,Y., Kira,A. and Hayashizaki,Y. TITLE RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer JOURNAL Genome Res. 10 (11), 1757-1771 (2000) MEDLINE 20530913 REFERENCE 4 AUTHORS Kawai,J., Shinagawa,A., Shibata,K., Yoshino,M., Itoh,M., Ishii,Y., Arakawa,T., Hara,A., Fukunishi,Y., Konno,H., Adachi,J., Fukuda,S., Aizawa,K., Izawa,M., Nishi,K., Kiyosawa,H., Kondo,S., Yamanaka,I., Saito,T., Okazaki,Y., Gojobori,T., Bono,H., Kasukawa,T., Saito,R., Kadota,K., Matsuda,H., Ashburner,M., Batalov,S., Casavant,T., Fleischmann,W., Gaasterland,T., Gissi,C., King,B., Kochiwa,H., Kuehl,P., Lewis,S., Matsuo,Y., Nikaido,I., Pesole,G., Quackenbush,J., Schriml,L.M., Staubli,F., Suzuki,R., Tomita,M., Wagner,L., Washio,T., Sakai,K., Okido,T., Furuno,M., Aono,H., Baldarelli,R., Barsh,G., Blake,J., Boffelli,D., Bojunga,N., Carninci,P., de Bonaldo,M.F., Brownstein,M.J., Bult,C., Fletcher,C., Fujita,M., Gariboldi,M., Gustincich,S., Hill,D., Hofmann,M., Hume,D.A., Kamiya,M., Lee,N.H., Lyons,P., Marchionni,L., Mashima,J., Mazzarelli,J., Mombaerts,P., Nordone,P., Ring,B., Ringwald,M., Rodriguez,I., Sakamoto,N., Sasaki,H., Sato,K., Schonbach,C., Seya,T., Shibata,Y., Storch,K.F., Suzuki,H., Toyo-oka,K., Wang,K.H., Weitz,C., Whittaker,C., Wilming,L., Wynshaw-Boris,A., Yoshida,K., Hasegawa,Y., Kawaji,H., Kohtsuki,S. and Hayashizaki,Y. TITLE Functional annotation of a full-length mouse cDNA collection JOURNAL Nature 409 (6821), 685-690 (2001) MEDLINE 21085660 REFERENCE 5 AUTHORS The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I & II Team. TITLE Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs JOURNAL Nature 420, 563-573 (2002) REFERENCE 6 (residues 1 to 598) AUTHORS Adachi,J., Aizawa,K., Akimura,T., Arakawa,T., Bono,H., Carninci,P., Fukuda,S., Furuno,M., Hanagaki,T., Hara,A., Hashizume,W., Hayashida,K., Hayatsu,N., Hiramoto,K., Hiraoka,T., Hirozane,T., Hori,F., Imotani,K., Ishii,Y., Itoh,M., Kagawa,I., Kasukawa,T., Katoh,H., Kawai,J., Kojima,Y., Kondo,S., Konno,H., Kouda,M., Koya,S., Kurihara,C., Matsuyama,T., Miyazaki,A., Murata,M., Nakamura,M., Nishi,K., Nomura,K., Numazaki,R., Ohno,M., Ohsato,N., Okazaki,Y., Saito,R., Saitoh,H., Sakai,C., Sakai,K., Sakazume,N., Sano,H., Sasaki,D., Shibata,K., Shinagawa,A., Shiraki,T., Sogabe,Y., Tagami,M., Tagawa,A., Takahashi,F., Takaku-Akahira,S., Takeda,Y., Tanaka,T., Tomaru,A., Toya,T., Yasunishi,A., Muramatsu,M. and Hayashizaki,Y. TITLE Direct Submission JOURNAL Submitted (16-APR-2002) Yoshihide Hayashizaki, The Institute of Physical and Chemical Research (RIKEN), Laboratory for Genome Exploration Research Group, RIKEN Genomic Sciences Center (GSC), RIKEN Yokohama Institute; 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan (E-mail:genome-res@gsc.riken.go.jp, URL:http://genome.gsc.riken.go.jp/, Tel:81-45-503-9222, Fax:81-45-503-9216) COMMENT cDNA library was prepared and sequenced in Mouse Genome Encyclopedia Project of Genome Exploration Research Group in Riken Genomic Sciences Center and Genome Science Laboratory in RIKEN. Division of Experimental Animal Research in Riken contributed to prepare mouse tissues. Please visit our web site for further details. URL:http://genome.gsc.riken.go.jp/ URL:http://fantom.gsc.riken.go.jp/. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|306769788| COMMENT VNTNAME|mSAP1_D1 (BAC37443)| COMMENT VNTAUTHORNAME|JNA| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|UNKNOWN| FEATURES Location/Qualifiers source 1..279 /organism="Mus musculus" /strain="C57BL/6J" /db_xref="FANTOM_DB:9030616J04" /db_xref="taxon:10090" /clone="9030616J04" /sex="male" /tissue_type="colon" /clone_lib="RIKEN full-length enriched mouse cDNA library" /dev_stage="adult" /vntifkey="269" Protein 1..279 /name="unnamed protein product" /vntifkey="270" ORIGIN 1 kdfadhvren ekdsncgfae eyqqlalegq gqsqitasal enrsknryrn vlpydwsrvp 61 lqplqeepgs dyinasfmpg lwspkefiat qgplpntvgd fwrmvweqqs htlvmltncm 121 esgrvkcehy wpldaqpcih gqlqvmlise easenwtvrh lqlfhmkeqq tlslrqfhyl 181 awpdhgvpys pdpllafrkm lrqwmdqttd ggppivhcsa gvgrtgtlia ldvllrqlec 241 eglvgpfsfv kkmresrplm vqteaqyvfl hqcilkslq // LOCUS mSHP1_D1\( 297 aa 17-MAY-2003 DEFINITION hemopoietic cell phosphatase [Mus musculus]. ACCESSION NP_038573 DBSOURCE REFSEQ: accession NM_013545.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 595) AUTHORS Paling,N.R. and Welham,M.J. TITLE Role of the protein tyrosine phosphatase SHP-1 (Src homology phosphatase-1) in the regulation of interleukin-3-induced survival, proliferation and signalling JOURNAL Biochem. J. 368 (Pt 3), 885-894 (2002) MEDLINE 22353944 REMARK GeneRIF: SHP-1 acts to negatively regulate IL-3-driven survival and proliferation, potentially via tyrosine phosphorylation of Aic2A and STAT5 REFERENCE 2 (residues 1 to 595) AUTHORS Kant,A.M., De,P., Peng,X., Yi,T., Rawlings,D.J., Kim,J.S. and Durden,D.L. TITLE SHP-1 regulates Fcgamma receptor-mediated phagocytosis and the activation of RAC JOURNAL Blood 100 (5), 1852-1859 (2002) MEDLINE 22165611 REMARK GeneRIF: SHP-1 is involved in the regulation of Fcgamma receptor-mediated phagocytosis REFERENCE 3 (residues 1 to 595) AUTHORS Mizuno,K., Tagawa,Y., Mitomo,K., Watanabe,N., Katagiri,T., Ogimoto,M. and Yakura,H. TITLE Src homology region 2 domain-containing phosphatase 1 positively regulates B cell receptor-induced apoptosis by modulating association of B cell linker protein with Nck and activation of c-Jun NH2-terminal kinase JOURNAL J. Immunol. 169 (2), 778-786 (2002) MEDLINE 22092269 REMARK GeneRIF: Src homology region 2 domain-containing phosphatase 1 (SHP-1) negatively regulates JN kinase activation by modulating the association of B cell linker protein with the adapter Nck and exerting a positive effect on B cell receptor-induced apoptosis. REFERENCE 4 (residues 1 to 595) AUTHORS Christianson,S.W., Greiner,D.L., Deluca,D., Leif,J., Phillips,N.E., Hayes,S.M., Hayashi,S., Joliat,M.J., Lyons,B.L. and Shultz,L.D. TITLE T cell developmental defects in 'viable motheaten' mice deficient in SHP-1 protein-tyrosine phosphatase. Developmental defects are corrected in vitro in the presence of normal hematopoietic-origin stromal cells and in vivo by exogenous IL-7 JOURNAL J. Autoimmun. 18 (2), 119-130 (2002) MEDLINE 21906933 REMARK GeneRIF: the use of fetal thymic organ culture (FTOC) and bone marrow adoptive transfer to study the effects of SHP-1 deficiency on thymocyte development REFERENCE 5 (residues 1 to 595) AUTHORS Joliat,M.J., Lang,P.A., Lyons,B.L., Burzenski,L., Lynes,M.A., Yi,T., Sundberg,J.P. and Shultz,L.D. TITLE Absence of CD5 dramatically reduces progression of pulmonary inflammatory lesions in SHP-1 protein-tyrosine phosphatase-deficient 'viable motheaten' mice JOURNAL J. Autoimmun. 18 (2), 105-117 (2002) MEDLINE 21906932 REMARK GeneRIF: Absence of CD5 dramatically reduces progression of pulmonary inflammatory lesions in SHP-1 protein-tyrosine phosphatase-deficient 'viable motheaten' mice. REFERENCE 6 (residues 1 to 595) AUTHORS Blasioli,J. and Goodnow,C.C. TITLE Lyn/CD22/SHP-1 and their importance in autoimmunity JOURNAL Curr. Dir. Autoimmun. 5, 151-160 (2002) MEDLINE 21685428 REMARK GeneRIF: The Lyn/CD22/SHP-1 pathway is important in autoimmunity. Naive and tolerant B-cells differ in their calcium signaling in response to antigenic stimulation. REFERENCE 7 (residues 1 to 595) AUTHORS Martin,A., Tsui,H.W., Shulman,M.J., Isenman,D. and Tsui,F.W. TITLE Murine SHP-1 splice variants with altered Src homology 2 (SH2) domains. Implications for the SH2-mediated intramolecular regulation of SHP-1 JOURNAL J. Biol. Chem. 274 (31), 21725-21734 (1999) MEDLINE 99348302 REFERENCE 8 (residues 1 to 595) AUTHORS Jiao,H., Berrada,K., Yang,W., Tabrizi,M., Platanias,L.C. and Yi,T. TITLE Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1 JOURNAL Mol. Cell. Biol. 16 (12), 6985-6992 (1996) MEDLINE 97098677 REFERENCE 9 (residues 1 to 595) AUTHORS Shultz,L.D., Schweitzer,P.A., Rajan,T.V., Yi,T., Ihle,J.N., Matthews,R.J., Thomas,M.L. and Beier,D.R. TITLE Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene JOURNAL Cell 73 (7), 1445-1454 (1993) MEDLINE 93313972 REFERENCE 10 (residues 1 to 595) AUTHORS Matthews,R.J., Bowne,D.B., Flores,E. and Thomas,M.L. TITLE Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences JOURNAL Mol. Cell. Biol. 12 (5), 2396-2405 (1992) MEDLINE 92236615 REFERENCE 11 (residues 1 to 595) AUTHORS Yi,T.L., Cleveland,J.L. and Ihle,J.N. TITLE Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13 JOURNAL Mol. Cell. Biol. 12 (2), 836-846 (1992) MEDLINE 92123209 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M68902.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302133570| COMMENT VNTNAME|mSHP1_D1 (NP_038573) Hcph| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..297 /organism="Mus musculus" /strain="DBA/2" /db_xref="taxon:10090" /chromosome="6" /map="6 60.22 cM" /cell_type="monocyte" /tissue_lib="lambda gt10" /vntifkey="269" Protein 1..297 /product="hemopoietic cell phosphatase" /vntifkey="270" Region 23..297 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 adienrvlel nkkqesedtr kagfweefes lqkqevknlh qrlegqrpen ksknryknil 61 pfdhsrvilq grdsnipgsd yinanyvknq llgpdenskt yiasqgclda tvndfwqmaw 121 qentrvivmt trevekgrnk cvpywpevgt qrvyglysvt nsrehdtaey klrtlqispl 181 dngdlvreiw hyqylswpdh gvpsepggvl sfldqinqrq eslphagpii vhcsagigrt 241 gtiividmlm esistkgldc didiqktiqm vraqrsgmvq teaqykfiyv aiaqfie // LOCUS mSHP2_D1\( 304 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 11; SH2 domain-containing protein tyrosine phosphatase-2 [Mus musculus]. ACCESSION NP_035332 DBSOURCE REFSEQ: accession NM_011202.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 597) AUTHORS Chen,B., Hammonds-Odie,L., Perron,J., Masters,B.A. and Bixby,J.L. TITLE SHP-2 mediates target-regulated axonal termination and NGF-dependent neurite growth in sympathetic neurons JOURNAL Dev. Biol. 252 (2), 170-187 (2002) MEDLINE 22370691 REMARK GeneRIF: NGF-regulated axon growth signals, and to a lesser degree survival signals, are mediated through a SHP-2-dependent pathway in sympathetic neurons REFERENCE 2 (residues 1 to 597) AUTHORS Wu,T.R., Hong,Y.K., Wang,X.D., Ling,M.Y., Dragoi,A.M., Chung,A.S., Campbell,A.G., Han,Z.Y., Feng,G.S. and Chin,Y.E. TITLE SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei JOURNAL J. Biol. Chem. 277 (49), 47572-47580 (2002) MEDLINE 22344627 REMARK GeneRIF: SHP-2 is a dual-specificity protein phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues and plays an important role in modulating STAT function in gene regulation REFERENCE 3 (residues 1 to 597) AUTHORS Tebbutt,N.C., Giraud,A.S., Inglese,M., Jenkins,B., Waring,P., Clay,F.J., Malki,S., Alderman,B.M., Grail,D., Hollande,F., Heath,J.K. and Ernst,M. TITLE Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice JOURNAL Nat. Med. 8 (10), 1089-1097 (2002) MEDLINE 22244556 REMARK GeneRIF: Data suggest that mucosal wound healing depends on activation of STAT1/3, whereas gastric hyperplasia ensues when the coordinated activation of the STAT1/3 and SHP2-Ras-ERK pathways is disrupted. REFERENCE 4 (residues 1 to 597) AUTHORS Zhang,S.Q., Tsiaras,W.G., Araki,T., Wen,G., Minichiello,L., Klein,R. and Neel,B.G. TITLE Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2 JOURNAL Mol. Cell. Biol. 22 (12), 4062-4072 (2002) MEDLINE 22022004 REMARK GeneRIF: Shp2 negatively regulates EGF-dependent PI3K activation by dephosphorylating Gab1 p85 binding sites, thereby terminating a previously proposed Gab1-PI3K positive feedback loop REFERENCE 5 (residues 1 to 597) AUTHORS Kontaridis,M.I., Liu,X., Zhang,L. and Bennett,A.M. TITLE Role of SHP-2 in fibroblast growth factor receptor-mediated suppression of myogenesis in C2C12 myoblasts JOURNAL Mol. Cell. Biol. 22 (11), 3875-3891 (2002) MEDLINE 21993147 REMARK GeneRIF: Role of SHP-2 in fibroblast growth factor receptor-mediated suppression of myogenesis in C2C12 myoblasts. REFERENCE 6 (residues 1 to 597) AUTHORS Yu,W.M., Hawley,T.S., Hawley,R.G. and Qu,C.K. TITLE Role of the docking protein Gab2 in beta(1)-integrin signaling pathway-mediated hematopoietic cell adhesion and migration JOURNAL Blood 99 (7), 2351-2359 (2002) MEDLINE 21892655 REFERENCE 7 (sites) AUTHORS Ohnishi,H., Kubota,M., Ohtake,A., Sato,K. and Sano,S. TITLE Activation of protein-tyrosine phosphatase SH-PTP2 by a tyrosine-based activation motif of a novel brain molecule JOURNAL J. Biol. Chem. 271 (41), 25569-25574 (1996) MEDLINE 96411777 REFERENCE 8 (residues 1 to 597) AUTHORS Feng,G.S., Hui,C.C. and Pawson,T. TITLE SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases JOURNAL Science 259 (5101), 1607-1611 (1993) MEDLINE 93206094 REFERENCE 9 (residues 1 to 597) AUTHORS Ohnishi,H. JOURNAL Unpublished (1996) COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D84372.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302133615| COMMENT VNTNAME|mSHP2_D1 (NP_035332) Ptpn11| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..304 /organism="Mus musculus" /strain="BALB/c" /db_xref="taxon:10090" /chromosome="5" /tissue_type="brain" /clone_lib="lambda gt11 Clontech ML1042b" /vntifkey="269" Protein 1..304 /product="protein tyrosine phosphatase, non-receptor type 11" /vntifkey="270" /note="SH2 domain-containing protein tyrosine phosphatase-2" Region 23..304 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 aeiesrvrel sklaettdkv kqgfweefet lqqqecklly srkegqrqen knknryknil 61 pfdhtrvvlh dgdpnepvsd yinaniimpe fetkcnnskp kksyiatqgc lqntvndfwr 121 mvfqensrvi vmttkeverg kskcvkywpd eyalkeygvm rvrnvkesaa hdytlrelkl 181 skvgqallqg ntertvwqyh frtwpdhgvp sdpggvldfl eevhhkqesi vdagpvvvhc 241 sagigrtgtf ividilidii rekgvdcdid vpktiqmvrs qrsgmvqtea qyrfiymavq 301 hyie // LOCUS mSTEP_D1\( 276 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 5 [Mus musculus]. ACCESSION NP_038671 DBSOURCE REFSEQ: accession NM_013643.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 541) AUTHORS Bult,A., Zhao,F., Dirkx,R. Jr., Raghunathan,A., Solimena,M. and Lombroso,P.J. TITLE STEP: a family of brain-enriched PTPs. Alternative splicing produces transmembrane, cytosolic and truncated isoforms JOURNAL Eur. J. Cell Biol. 72 (4), 337-344 (1997) MEDLINE 97273253 REFERENCE 2 (residues 1 to 541) AUTHORS Bult,A., Zhao,F., Dirkx,R. Jr., Sharma,E., Lukacsi,E., Solimena,M., Naegele,J.R. and Lombroso,P.J. TITLE STEP61: a member of a family of brain-enriched PTPs is localized to the endoplasmic reticulum JOURNAL J. Neurosci. 16 (24), 7821-7831 (1996) MEDLINE 97141509 REFERENCE 3 (residues 1 to 541) AUTHORS Sharma,E., Zhao,F., Bult,A. and Lombroso,P.J. TITLE Identification of two alternatively spliced transcripts of STEP: a subfamily of brain-enriched protein tyrosine phosphatases JOURNAL Brain Res. Mol. Brain Res. 32 (1), 87-93 (1995) MEDLINE 96115113 REFERENCE 4 (residues 1 to 541) AUTHORS Lombroso,P., Zhao,F., Bult,A., Sharma,E., Solimena,M. and Naegele,J. TITLE A new member of the STEP family of protein tyrosine phosphatases JOURNAL Unpublished COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U28217.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302133454| COMMENT VNTNAME|mSTEP_D1 (NP_038671) Ptpn5| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..276 /organism="Mus musculus" /strain="BALB/c" /db_xref="taxon:10090" /chromosome="7" /map="7 53.0 cM" /clone_lib="lambda gt11 cDNA brain library of Clontech (ML1042b)" /dev_stage="adult" /vntifkey="269" Protein 1..276 /product="protein tyrosine phosphatase, non-receptor type 5" /vntifkey="270" Region 18..274 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 srvlraeelh ekaldpfllq aeffeipmnf vdpkeydipg lvrknrykti lpnphsrvrl 61 tspdpedpls syinanyirg ysgeekvyia tqgpivstva dfwrmvwqer tpiivmitni 121 eemnekctey wpeeqvvhdg veitvqkvih tedyrlrlis lrrgteertl khywftswpd 181 qktpdrappl lhlvreveea aqqegphcsp iivhcsagig rtgcfiatsi ccqqlrregv 241 vdilkttcql rqdrggmiqt ceqyqfvhha mslyek // LOCUS mTCPTP_D1\ 275 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 2 [Mus musculus]. ACCESSION NP_033003 DBSOURCE REFSEQ: accession NM_008977.1 SOURCE Mus musculus (house mouse). ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 382) AUTHORS Zhu,W., Mustelin,T. and David,M. TITLE Arginine methylation of STAT1 regulates its dephosphorylation by T cell protein tyrosine phosphatase JOURNAL J. Biol. Chem. 277 (39), 35787-35790 (2002) MEDLINE 22229439 REMARK GeneRIF: TcPTP phosphorylation is regulated by STAT1 REFERENCE 2 (residues 1 to 382) AUTHORS Miyasaka,H. and Li,S.S. TITLE Molecular cloning, nucleotide sequence and expression of a cDNA encoding an intracellular protein tyrosine phosphatase, PTPase-2, from mouse testis and T-cells JOURNAL Mol. Cell. Biochem. 118 (1), 91-98 (1992) MEDLINE 93140736 REFERENCE 3 (residues 1 to 382) AUTHORS Mosinger,B. Jr., Tillmann,U., Westphal,H. and Tremblay,M.L. TITLE Cloning and characterization of a mouse cDNA encoding a cytoplasmic protein-tyrosine-phosphatase JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (2), 499-503 (1992) MEDLINE 92115688 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M81477.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302141868| COMMENT VNTNAME|mTCPTP_D1 (NP_033003) Ptpn2| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..275 /organism="Mus musculus" /db_xref="taxon:10090" /chromosome="18" /dev_stage="embryo" /vntifkey="269" Protein 1..275 /product="protein tyrosine phosphatase, non-receptor type 2" /vntifkey="270" Region 3..275 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 atierefeel daqcrwqply leirneshdy phrvakfpen rnrnryrdvs pydhsrvklq 61 stendyinas lvdieeaqrs yiltqgplpn tcchfwlmvw qqktkavvml nrtvekesvk 121 caqywptddr emvfketgfs vkllsedvks yytvhllqle nintgetrti shfhyttwpd 181 fgvpespasf lnflfkvres gcltpdhgpa vihcsagigr sgtfslvdtc lvlmekgedv 241 nvkqlllnmr kyrmgliqtp dqlrfsymai iegak // LOCUS rabPTPoc_D 277 aa 2-JUL-2003 DEFINITION phosphotyrosyl phosphatase. ACCESSION AAB16824 DBSOURCE locus OCU32587 accession U32587.1 SOURCE Oryctolagus cuniculus (rabbit). ORGANISM Oryctolagus cuniculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Lagomorpha; Leporidae; Oryctolagus. REFERENCE 1 (residues 1 to 405) AUTHORS Wu,L.W., Baylink,D.J. and Lau,K.H. TITLE Molecular cloning and expression of a unique rabbit osteoclastic phosphotyrosyl phosphatase JOURNAL Biochem. J. 316 (Pt 2), 515-523 (1996) MEDLINE 96257745 REFERENCE 2 (residues 1 to 405) AUTHORS Wu,L.W. TITLE Direct Submission JOURNAL Submitted (28-JUL-1995) Li-Wha Wu, Jerry L. Pettis Memorial Veteran Affairs Medical Center, Mineral Metabolism Unit - 151, 11201 Benton Street, Loma Linda, CA 92357, USA COMMENT Method: conceptual translation. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|307069759| COMMENT VNTNAME|rabPTPoc_D1 (AAB16824)| COMMENT VNTAUTHORNAME|JNA| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|UNKNOWN| FEATURES Location/Qualifiers source 1..277 /organism="Oryctolagus cuniculus" /db_xref="taxon:9986" /cell_type="osteoclast" /tissue_type="bone" /clone_lib="Lamda ZAPII library of Dr. M. Kumegawa" /dev_stage="infant" /vntifkey="269" Protein 1..277 /product="phosphotyrosyl phosphatase" /EC_number="3.1.3.48" /vntifkey="270" ORIGIN 1 ddfdayikdm akdsdykfsl qfeelkligl diphfaadlp lnrcknrytn ilpydfsrvr 61 llsmneeega dyinanyipg ynspqeyiat qgplpetrnd fwkmvlqqks qmivmltqcn 121 ekrrvkcdhy wpfteepiay gditvemise eeqddwahrh frinyademq dvmhfnytaw 181 pdhgvptana aesilqfvhm vrqqatkskg pmiihcsagv grtgtfiald rllqhirdhe 241 fvdilglvse mrsyrmsmvq teeqyifihq cvqlmwm // LOCUS rCD45_D1\( 279 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor-type, c polypeptide (antigen Cd45, leukocyte-common antigen/T200 glycoprotein) also RT7 [Rattus norvegicus]. ACCESSION XP_213985 DBSOURCE REFSEQ: accession XM_213985.1 SOURCE Rattus norvegicus (Norway rat). ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. COMMENT GENOME ANNOTATION REFSEQ: This model reference sequence was predicted from NCBI contig NW_042865 by automated computational analysis using gene prediction method: BLAST, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302203804| COMMENT VNTNAME|rCD45_D1 (XP_213985) Ptprc| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..279 /organism="Rattus norvegicus" /strain="BN/SsNHsd/MCW" /db_xref="taxon:10116" /chromosome="13" /vntifkey="269" Protein 1..279 /product="protein tyrosine phosphatase, receptor-type, c polypeptide (antigen Cd45, leukocyte-common antigen/T200 glycoprotein) also RT7" /vntifkey="270" Region 17..277 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" Region 30..279 /region_name="Protein tyrosine phosphatase [Signal transduction mechanisms]" /db_xref="CDD:COG5599" /vntifkey="266" /label=Region_2 /note="PTP2" Region 42..276 /region_name="Protein-tyrosine phosphatase" /db_xref="CDD:pfam00102" /vntifkey="266" /label=Region_3 /note="Y_phosphatase" Region 155..279 /region_name="Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]" /db_xref="CDD:COG2453" /vntifkey="266" /label=Region_4 /note="CDC14" Region 175..276 /region_name="Protein tyrosine phosphatase, catalytic domain motif" /db_xref="CDD:smart00404" /vntifkey="266" /label=Region_5 /note="PTPc_motif" ORIGIN 1 dllletykrk iadegrlfla efqsiprvfs kfpikdarks qnqnknryvd ilpydynrve 61 lseingdags tyinasyidg fkeprkyiaa qgprdetvdd fwkmiweqka tvivmvtrce 121 egnrnkcaey wpcmeegtrt frdvvvtind hkrcpdyiiq klsiahkkek atgrevthiq 181 ftswpdhgvp edphlllklr rrvnafsnff sgpivvhcsa gvgrtgtyig idamleslea 241 egkvdvygyv vnlrrqrclm vqveaqyili hqalveynq // LOCUS rDEP1_D1\( 277 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, J [Rattus norvegicus]. ACCESSION NP_058965 DBSOURCE REFSEQ: accession NM_017269.1 SOURCE Rattus norvegicus (Norway rat). ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. REFERENCE 1 (residues 1 to 1216) AUTHORS Borges,L.G., Seifert,R.A., Grant,F.J., Hart,C.E., Disteche,C.M., Edelhoff,S., Solca,F.F., Lieberman,M.A., Lindner,V., Fischer,E.H., Lok,S. and Bowen-Pope,D.F. TITLE Cloning and characterization of rat density-enhanced phosphatase-1, a protein tyrosine phosphatase expressed by vascular cells JOURNAL Circ. Res. 79 (3), 570-580 (1996) MEDLINE 96375109 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U40790.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302204296| COMMENT VNTNAME|rDEP1_D1 (NP_058965) Ptprj| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..277 /organism="Rattus norvegicus" /strain="WKY" /db_xref="taxon:10116" /chromosome="3" /map="3q32-q33" /cell_type="vascular smooth muscle cells" /tissue_type="aorta" /dev_stage="12 days old" /vntifkey="269" Protein 1..277 /product="protein tyrosine phosphatase, receptor type, J" /vntifkey="270" Region 17..277 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 enfeayfkkq qadsncgfae eyedlkligi slpkyaaeia enrgknrynn vlpydisrvk 61 lsvqthstdd yinanympgy hskkdfiatq gplpntlkdf wrmvweknvy aivmltkcve 121 qgrtkceeyw pskqaqdygd itvamtsevv lpewtirdfv vknmqssesh plrqfhftsw 181 pdhgvpdttd llinfrylvr dymkqippes pilvhcsagv grtgtfiaid rliyqienen 241 tvdvygivyd lrmhrplmvq tedqyvflnq cvldiir // LOCUS rGLEPP1_D1 277 aa 17-MAY-2003 DEFINITION receptor-type protein tyrosine phosphatase D30 [Rattus norvegicus]. ACCESSION NP_059032 DBSOURCE REFSEQ: accession NM_017336.1 SOURCE Rattus norvegicus (Norway rat). ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. REFERENCE 1 (residues 1 to 1216) AUTHORS Kim,Y.H., Goyal,M., Wharram,B., Wiggins,J., Kershaw,D. and Wiggins,R. TITLE GLEPP1 receptor tyrosine phosphatase (Ptpro) in rat PAN nephrosis. A marker of acute podocyte injury JOURNAL Nephron 90 (4), 471-476 (2002) MEDLINE 21959466 REMARK GeneRIF: Results suggest that GLEPP1 (Ptrpo) expression reflects podocyte injury induced by puromycin aminonucleoside. REFERENCE 2 (residues 1 to 1216) AUTHORS Tagawa,M., Shirasawa,T., Yahagi,Y., Tomoda,T., Kuroyanagi,H., Fujimura,S., Sakiyama,S. and Maruyama,N. TITLE Identification of a receptor-type protein tyrosine phosphatase expressed in postmitotic maturing neurons: its structure and expression in the central nervous system JOURNAL Biochem. J. 321 (Pt 3), 865-871 (1997) MEDLINE 97184676 REFERENCE 3 (residues 1 to 1216) AUTHORS Tagawa,M., Shirasawa,T., Fujimura,S. and Sakiyama,S. TITLE Identification of a rat protein tyrosine phosphatase gene preferentially expressed in the embryonal brain JOURNAL Cell. Mol. Biol. Res. 40 (7-8), 627-631 (1994) MEDLINE 95307601 REFERENCE 4 (residues 1 to 1216) AUTHORS Tanaka,S., Tamura,K. and Mizuno,Y. TITLE Clinical consideration with special reference to autopsy cases of malignant tumor in the oral cavity, treated with Bleomycin (author's transl) JOURNAL Hiroshima Daigaku Shigaku Zasshi 8 (2), 168-175 (1975) MEDLINE 77228640 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U28938.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302204168| COMMENT VNTNAME|rGLEPP1_D1 (NP_059032) Ptpro| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..277 /organism="Rattus norvegicus" /strain="W" /db_xref="taxon:10116" /chromosome="4" /map="4q44" /clone="PTPD30" /tissue_type="brain" /dev_stage="embryo" /vntifkey="269" Protein 1..277 /product="receptor-type protein tyrosine phosphatase D30" /vntifkey="270" Region 17..272 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 ddfdsyikdm akdsdykfsl qfeelkligl diphfaadlp lnrcknrytn ilpydfsrvr 61 lvsmneeega dyinanyipg ynspqeyiat qgplpetrnd fwkmvlqqks riivmltqcn 121 ekrrvkcdhy wpfteepiay gditvemvse eeqedwasrh frinyadeaq dvmhfnytaw 181 pdhgvppana aesilqfvyt vrqqatkskg pmiihcsagv grtgtfiald rllqhirdhe 241 fvdilglvse mrsyrmsmvq teeqyifihq cvqlmwl // LOCUS rIA2_D1\(N 279 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, N [Rattus norvegicus]. ACCESSION NP_446333 DBSOURCE REFSEQ: accession NM_053881.1 SOURCE Rattus norvegicus (Norway rat). ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. REFERENCE 1 (residues 1 to 983) AUTHORS Lobner,K., Steinbrenner,H., Roberts,G.A., Ling,Z., Huang,G.C., Piquer,S., Pipeleers,D.G., Seissler,J. and Christie,M.R. TITLE Different regulated expression of the tyrosine phosphatase-like proteins IA-2 and phogrin by glucose and insulin in pancreatic islets: relationship to development of insulin secretory responses in early life JOURNAL Diabetes 51 (10), 2982-2988 (2002) MEDLINE 22238600 REMARK GeneRIF: Different regulated expression of the tyrosine phosphatase-like proteins IA-2 and phogrin by glucose and insulin in pancreatic islets: relationship to development of insulin secretory responses in early life. REFERENCE 2 (residues 1 to 983) AUTHORS Payton,M.A., Hawkes,C.J. and Christie,M.R. TITLE Relationship of the 37,000- and 40,000-M(r) tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512) JOURNAL J. Clin. Invest. 96 (3), 1506-1511 (1995) MEDLINE 95386708 REFERENCE 3 AUTHORS Passini,N., Larigan,J.D., Genovese,S., Appella,E., Sinigaglia,F. and Rogge,L. TITLE The 37/40-kilodalton autoantigen in insulin-dependent diabetes mellitus is the putative tyrosine phosphatase IA-2 JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (20), 9412-9416 (1995) MEDLINE 96016179 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X92563.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302205153| COMMENT VNTNAME|rIA2_D1 (NP_446333) Ptprn| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..279 /organism="Rattus norvegicus" /db_xref="taxon:10116" /haplotype="RIN 5AH" /cell_line="RIN 5AH" /vntifkey="269" Protein 1..279 /product="protein tyrosine phosphatase, receptor type, N" /vntifkey="270" Region 17..278 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 hmilaymedh lrnrdrlakk wqalcayqae pntcataqge gnikknrhpd flpydharik 61 lkvesspsrs dyinaspiie hdprmpayia tqgplshtia dfwqmvwesg ctvivmltpl 121 vedgvkqcdr ywpdegssly hvyevnlvse hiwcedflvr sfylknvqtq etrtltqfhf 181 lswpaegtpa strplldfrr kvnkcyrgrs cpiivhcsdg agrtgtyili dmvlnrmakg 241 vkeidiaatl ehvrdqrpgl vrskdqfefa ltavaeevn // LOCUS rLAR_D1\(N 275 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, F; protein tyrosine phosphatase, receptor-type, F [Rattus norvegicus]. ACCESSION NP_062122 DBSOURCE REFSEQ: accession NM_019249.1 SOURCE Rattus norvegicus (Norway rat). ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. REFERENCE 1 (residues 1 to 1898) AUTHORS Zhang,J.S. and Longo,F.M. TITLE LAR tyrosine phosphatase receptor: alternative splicing is preferential to the nervous system, coordinated with cell growth and generates novel isoforms containing extensive CAG repeats JOURNAL J. Cell Biol. 128 (3), 415-431 (1995) MEDLINE 95146548 REFERENCE 2 (residues 1 to 1898) AUTHORS Zhang,W.R., Hashimoto,N., Ahmad,F., Ding,W. and Goldstein,B.J. TITLE Molecular cloning and expression of a unique receptor-like protein-tyrosine-phosphatase in the leucocyte-common-antigen-related phosphate family JOURNAL Biochem. J. 302 (Pt 1), 39-47 (1994) MEDLINE 94347119 REFERENCE 3 (residues 1 to 1898) AUTHORS Longo,F.M., Martignetti,J.A., Le Beau,J.M., Zhang,J.S., Barnes,J.P. and Brosius,J. TITLE Leukocyte common antigen-related receptor-linked tyrosine phosphatase. Regulation of mRNA expression JOURNAL J. Biol. Chem. 268 (35), 26503-26511 (1993) MEDLINE 94075340 REFERENCE 4 (residues 1 to 1898) AUTHORS Pot,D.A., Woodford,T.A., Remboutsika,E., Haun,R.S. and Dixon,J.E. TITLE Cloning, bacterial expression, purification, and characterization of the cytoplasmic domain of rat LAR, a receptor-like protein tyrosine phosphatase JOURNAL J. Biol. Chem. 266 (29), 19688-19696 (1991) MEDLINE 92011772 REFERENCE 5 (residues 1 to 1898) AUTHORS Streuli,M., Krueger,N.X., Hall,L.R., Schlossman,S.F. and Saito,H. TITLE A new member of the immunoglobulin superfamily that has a cytoplasmic region homologous to the leukocyte common antigen JOURNAL J. Exp. Med. 168 (5), 1523-1530 (1988) MEDLINE 89035978 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L11586.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302204026| COMMENT VNTNAME|rLAR_D1 (NP_062122) Ptprf| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..275 /organism="Rattus norvegicus" /strain="Sprague-Dawley" /db_xref="taxon:10116" /chromosome="5" /map="5q36" /sex="male" /tissue_type="liver" /dev_stage="7-8 weeks old" /vntifkey="269" Protein 1..275 /product="protein tyrosine phosphatase, receptor type, F" /function="protein-tyrosine phosphatase" /vntifkey="270" /note="protein tyrosine phosphatase, receptor-type, F" Region 1..275 /gene="LAR" /product="protein tyrosine phosphatase, receptor type, F" /EC_number="3.1.3.48" /standard_name="LAR protein" /vntifkey="203" /label=LAR /note="putative" Region 17..275 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_4 /note="PTPc" ORIGIN 1 tdladnierl kandglkfsq eyesidpgqq ftwensnsev nkpknryanv iaydhsrvll 61 tsidgvpgsd yinanyidgy rkqnayiatq gplpetmgdf wrmvweqria tvvmmtrlee 121 ksrvkcdqyw pargtetygl iqvtlvdtve latytmrtfa lhksgssekr elrqfqfmaw 181 pdhgvpeypt pilaflrrvk acnpldagpm vvhcsagvgr tgcfividam lermkhektv 241 diyghvtcmr sqrnymvqte dqyvfiheal leaam // LOCUS rLCPTP_D1\ 272 aa 17-MAY-2003 DEFINITION Protein-tyrosine phosphatase, non-receptor type 7 (Protein-tyrosine phosphatase LC-PTP) (Hematopoietic protein-tyrosine phosphatase) (HEPTP). ACCESSION P49445 DBSOURCE swissprot: locus PTN7_RAT, accession P49445; class: standard. created: Feb 1, 1996. sequence updated: Feb 1, 1996. annotation updated: Oct 16, 2001. xrefs: gi: 886816, gi: 886817 xrefs (non-sequence databases): HSSPP18031, InterProIPR000387, InterProIPR000242, PfamPF00102, PRINTSPR00700, SMARTSM00194, PROSITEPS00383, PROSITEPS50056, PROSITEPS50055 KEYWORDS Hydrolase. SOURCE Rattus norvegicus (Norway rat). ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. REFERENCE 1 (residues 1 to 359) AUTHORS Swieter,M., Berenstein,E.H., Swaim,W.D. and Siraganian,R.P. TITLE Aggregation of IgE receptors in rat basophilic leukemia 2H3 cells induces tyrosine phosphorylation of the cytosolic protein-tyrosine phosphatase HePTP JOURNAL J. Biol. Chem. 270 (37), 21902-21906 (1995) MEDLINE 95394959 REMARK SEQUENCE FROM N.A. COMMENT ------------------------------------------------------------------- This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. The original entry is available from http://www.expasy.ch/sprot and http://www.ebi.ac.uk/sprot ------------------------------------------------------------------. [FUNCTION] MAY PLAY A ROLE IN THE REGULATION OF T AND B LYMPHOCYTE DEVELOPMENT AND SIGNAL TRANSDUCTION (BY SIMILARITY). [CATALYTIC ACTIVITY] PROTEIN TYROSINE PHOSPHATE + H(2)O = PROTEIN TYROSINE + ORTHOPHOSPHATE. [SUBCELLULAR LOCATION] CYTOPLASMIC (BY SIMILARITY). [SIMILARITY] BELONGS TO THE NON-RECEPTOR CLASS OF THE PROTEIN-TYROSINE PHOSPHATASE FAMILY. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302206482| COMMENT VNTNAME|rLCPTP_D1 (P49445) Ptpn7| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..272 /organism="Rattus norvegicus" /db_xref="taxon:10116" /vntifkey="269" Protein 1..272 /gene="PTPN7" /product="Protein-tyrosine phosphatase, non-receptor type 7" /EC_number="3.1.3.48" /vntifkey="270" Region 40..263 /gene="PTPN7" /region_name="Domain" /vntifkey="1000" /label=PTPN7 /note="PROTEIN-TYROSINE PHOSPHATASE." Site 0..0 /gene="PTPN7" /site_type="active" /vntifkey="220" /label=PTPN7 /note="BY SIMILARITY." ORIGIN 1 hpltrwtlqh qppspkqlee eflkipsnfv npedldipgh askdryktil pnpqsrvclg 61 rahsqedsdy inanyirgyd gkekvyiatq gpmpntvadf wemvwqedvs livmltqlre 121 gkekcvhywp teeeaygpfq iriqgmkehp eytvrhltiq hqqecrsvkh ilfsawpdhq 181 tpesagpllr lvaevetpet aansgpivvh csagigrtgc fiatrigcqq lkargevdil 241 givcqlrldr ggmiqtaeqy qflhhtlaly aa // LOCUS rOSTPTP_D1 279 aa 17-MAY-2003 DEFINITION Osteotesticular phosphatase; protein tyrosine phosphatase, receptor type, W [Rattus norvegicus]. ACCESSION NP_149090 DBSOURCE REFSEQ: accession NM_033099.1 SOURCE Rattus norvegicus (Norway rat). ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. REFERENCE 1 (residues 1 to 1711) AUTHORS Mauro,L.J., Olmsted,E.A., Skrobacz,B.M., Mourey,R.J., Davis,A.R. and Dixon,J.E. TITLE Identification of a hormonally regulated protein tyrosine phosphatase associated with bone and testicular differentiation JOURNAL J. Biol. Chem. 269 (48), 30659-30667 (1994) MEDLINE 95074080 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L36884.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302204378| COMMENT VNTNAME|rOSTPTP_D1 (NP_149090) Esp| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..279 /organism="Rattus norvegicus" /db_xref="taxon:10116" /chromosome="13" /map="13q1" /cell_line="UMR106 osteosarcoma" /tissue_type="bone" /vntifkey="269" Protein 1..279 /product="Osteotesticular phosphatase" /vntifkey="270" /note="protein tyrosine phosphatase, receptor type, W" Region 1..279 /gene="OST-PTP" /product="Osteotesticular phosphatase" /EC_number="3.1.3.48" /vntifkey="203" /label=OST-PTP Region 18..279 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 hsfrqsyeak sahahqtffq efeelkevgk dqprleaehp dniiknryph vlpydhsrvr 61 ltqlpgephs dyinanfipg yshtqeiiat qgplkktled fwrlvweqqv hviimltvgm 121 engrvlcehy wpanstpvth ghitihllae epedewtrre fqlqhgteqk qrrvkqlqft 181 twpdhsvpea pssllafvel vqeqvqatqg kgpilvhcsa gvgrtgtfva llrllrqlee 241 ekvadvfntv yilrlhrplm iqtlsqyifl hscllnkil // LOCUS rPCPTP1_D1 275 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, R; protein tyrosine phosphatase PCPTP1 [Rattus norvegicus]. ACCESSION NP_446046 DBSOURCE REFSEQ: accession NM_053594.1 SOURCE Rattus norvegicus (Norway rat). ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. REFERENCE 1 (sites) AUTHORS Shiozuka,K., Watanabe,Y., Ikeda,T., Hashimoto,S. and Kawashima,H. TITLE Cloning and expression of PCPTP1 encoding protein tyrosine phosphatase JOURNAL Gene 162 (2), 279-284 (1995) MEDLINE 96032358 REFERENCE 2 (residues 1 to 369) AUTHORS Sharma,E. and Lombroso,P.J. TITLE A neuronal protein tyrosine phosphatase induced by nerve growth factor JOURNAL J. Biol. Chem. 270 (1), 49-53 (1995) MEDLINE 95113874 REFERENCE 3 (residues 1 to 369) AUTHORS Shiozuka,K., Watanabe,Y., Ikeda,T., Hashimoto,S. and Kawashima,H. TITLE Molecular cloning and expression of JOURNAL Unpublished COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D38292.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302204525| COMMENT VNTNAME|rPCPTP1_D1 (NP_446046) Ptprr| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..275 /organism="Rattus norvegicus" /db_xref="taxon:10116" /chromosome="7" /map="7q21" /cell_line="PC12h" /cell_type="phenochromocytoma" /clone_lib="Bacteriophage lambda ZAPII" /vntifkey="269" Protein 1..275 /product="protein tyrosine phosphatase, receptor type, R" /vntifkey="270" /note="protein tyrosine phosphatase PCPTP1" Region 18..270 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 srvltspqlr dvvasshllq sefmeipmnf vdpkeidipr hgtknrykti lpnplsrvcl 61 rpknitdpls tyinanyirg ysgkekafia tqgpmintvn dfwqmvwqed spvivmitkl 121 keknekcvly wpekrgiygk vevlvigvne cdnytirnlv lkrgshtqhv khywytswpd 181 hktpdsaqpl lqlmldveed rlasegrgpv vvhcsagigr tgcfiatsig cqqlkeegvv 241 dalsivcqlr vdrggmvqts eqyefvhhal clfes // LOCUS rPTP1B_D1\ 279 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 1; Protein-tyrosine phosphatase [Rattus norvegicus]. ACCESSION NP_036769 DBSOURCE REFSEQ: accession NM_012637.1 SOURCE Rattus norvegicus (Norway rat). ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. REFERENCE 1 (residues 1 to 432) AUTHORS Zhen,X., Torres,C., Cai,G. and Friedman,E. TITLE Inhibition of protein tyrosine/mitogen-activated protein kinase phosphatase activity is associated with D2 dopamine receptor supersensitivity in a rat model of Parkinson's disease JOURNAL Mol. Pharmacol. 62 (6), 1356-1363 (2002) MEDLINE 22323550 REMARK GeneRIF: attenuation of the PTP/MKP pathway may be responsible for the development of D(2)DR supersensitivity. REFERENCE 2 (residues 1 to 432) AUTHORS Guan,K.L., Haun,R.S., Watson,S.J., Geahlen,R.L. and Dixon,J.E. TITLE Cloning and expression of a protein-tyrosine-phosphatase JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (4), 1501-1505 (1990) MEDLINE 90160354 REFERENCE 3 (residues 1 to 432) AUTHORS Tanaka,S., Tamura,K. and Mizuno,Y. TITLE Clinical consideration with special reference to autopsy cases of malignant tumor in the oral cavity, treated with Bleomycin (author's transl) JOURNAL Hiroshima Daigaku Shigaku Zasshi 8 (2), 168-175 (1975) MEDLINE 77228640 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M33962.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302205010| COMMENT VNTNAME|rPTP1B_D1 (NP_036769) Ptpn1| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..279 /organism="Rattus norvegicus" /db_xref="taxon:10116" /chromosome="3" /map="3q42" /clone="PTP1-3" /tissue_type="hypothalamus" /vntifkey="269" Protein 1..279 /product="protein tyrosine phosphatase, non-receptor type 1" /vntifkey="270" /note="Protein-tyrosine phosphatase" Region 3..279 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 memekefeqi dkagnwaaiy qdirheasdf pcriaklpkn knrnryrdvs pfdhsriklh 61 qedndyinas likmeeaqrs yiltqgplpn tcghfwemvw eqksrgvvml nrimekgslk 121 caqywpqkee kemvfddtnl kltlisedvk syytvrqlel enlatqeare ilhfhyttwp 181 dfgvpespas flnflfkvre sgslspehgp ivvhcsagig rsgtfcladt clllmdkrkd 241 pssvdikkvl lemrrfrmgl iqtadqlrfs ylaviegak // LOCUS rPTP20_D1\ 288 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase 20 [Rattus norvegicus]. ACCESSION AAC52896 DBSOURCE locus RNU69673 accession U69673.1 SOURCE Rattus norvegicus (Norway rat). ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. REFERENCE 1 (residues 1 to 453) AUTHORS Aoki,N., Yamaguchi-Aoki,Y. and Ullrich,A. TITLE The novel protein-tyrosine phosphatase PTP20 is a positive regulator of PC12 cell neuronal differentiation JOURNAL J. Biol. Chem. 271 (46), 29422-29426 (1996) MEDLINE 97067206 REFERENCE 2 (residues 1 to 453) AUTHORS Aoki,N., Yamaguchi-Aoki,Y. and Ullrich,A. TITLE Direct Submission JOURNAL Submitted (06-SEP-1996) Molecular Biology, Max-Planck-Institut fur Biochemie, Am Klopferspitz 18A, Martinsried 82152, Germany COMMENT COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302204929| COMMENT VNTNAME|rPTP20_D1 (AAC52896)| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..288 /organism="Rattus norvegicus" /db_xref="taxon:10116" /cell_line="PC12" /vntifkey="269" Protein 1..288 /product="protein tyrosine phosphatase 20" /vntifkey="270" ORIGIN 1 dlvrsfleqq eardhrkgai larefsdika rsvawktegv cstkagsqqg nskknrykdv 61 vpydetrvil sllqeeghgd yinanfirgt dgsqayiatq gplphtlldf wrlvwefgik 121 vilmacqete ngrrkceryw aqereplqag pfcitltket altsditlrt lqvtfqkesr 181 pvhqlqymsw pdhgvpsssd hiltmveear clqglgpgpl cvhcsagcgr tgvlcavdyv 241 rqllltqtip pnfslfevvl emrkqrpaav qteeqyrfly htvaqlfs // LOCUS rPTP2E_D1\ 292 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase 2E [Rattus norvegicus]. ACCESSION NP_598229 DBSOURCE REFSEQ: accession NM_133545.1 SOURCE Rattus norvegicus (Norway rat). ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. REFERENCE 1 (residues 1 to 1175) AUTHORS L'Abbe,D., Banville,D., Tong,Y., Stocco,R., Masson,S., Ma,S., Fantus,G. and Shen,S.H. TITLE Identification of a novel protein tyrosine phosphatase with sequence homology to the cytoskeletal proteins of the band 4.1 family JOURNAL FEBS Lett. 356 (2-3), 351-356 (1994) MEDLINE 95104449 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U17971.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302204764| COMMENT VNTNAME|rPTP2E_D1 (NP_598229) Ptp2E| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..292 /organism="Rattus norvegicus" /strain="Sprague-Dawley" /db_xref="taxon:10116" /chromosome="6" /map="6q31" /clone_lib="rat decidual tissue from Stratagene, catalog number 936505" /vntifkey="269" Protein 1..292 /product="protein tyrosine phosphatase 2E" /vntifkey="270" Region 19..292 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_2 /note="PTPc" ORIGIN 1 atnderckvl eqrleqgtvf teyerilkkr lvdgecstar lpenaernrf qdvlpyddar 61 velvptkenn tgyinashik vsvsgiewdy iatqgplqnt cqdfwqmvwe qgvaiiamvt 121 aeeeggreks frywprlgsr hntvtygrfk ittrfrtdsg cyattglkmk hlltgqertv 181 whlqytdwpe hgcpedlkgf lsyleeiqsv rrhtnstsep rspnppllvh csagvgrtgv 241 vilseimvac lehnevldip rvlellrqqr mmlvqtlsqy tfvyrvliqf lk // LOCUS rPTPalpha_ 280 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, A [Rattus norvegicus]. ACCESSION NP_036895 DBSOURCE REFSEQ: accession NM_012763.1 SOURCE Rattus norvegicus (Norway rat). ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. REFERENCE 1 (residues 1 to 796) AUTHORS Moriyama,T., Fujiwara,Y., Imai,E., Takenaka,M., Kawanishi,S., Inoue,T., Noguchi,T., Tanaka,T., Kamada,T. and Ueda,N. TITLE cDNA cloning of rat LRP, a receptor like protein tyrosine phosphatase, and evidence for its gene regulation in cultured rat mesangial cells JOURNAL Biochem. Biophys. Res. Commun. 188 (1), 34-39 (1992) MEDLINE 93038682 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L01702.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302203693| COMMENT VNTNAME|rPTPalpha_D1 (NP_036895) Ptpra| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..280 /organism="Rattus norvegicus" /strain="Sprague-Dawley" /db_xref="taxon:10116" /chromosome="3" /map="3q36" /tissue_type="kidney" /dev_stage="adult" /vntifkey="269" Protein 1..280 /product="protein tyrosine phosphatase, receptor type, A" /vntifkey="270" Region 17..280 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 dkleeeinrr maddnklfre efnalpacpi qatceaaske enkeknryvn llpydhsrvh 61 ltpvegvpds dyinasfing yqeknkfiaa qgpkeetvnd fwrmiweqnt ativmvtnlk 121 erkeckcaqy wpdqgcwpyg nvrvsvedvt vlvdytvrkf ciqqvgdvtn rkpqrlitqf 181 hftswpdfgv pftpigmlkf lkkvkacnpq yagaivvhcs agvgrtgtfv vidamldmmh 241 serkvdvygf vsriraqrcq mvqtdmqyvf iyqallehyl // LOCUS rPTPBEM2_D 279 aa 17-MAY-2003 DEFINITION brain-enriched membrane-associated protein tyrosine BEM-2 [Rattus norvegicus]. ACCESSION NP_598276 DBSOURCE REFSEQ: accession NM_133592.1 SOURCE Rattus norvegicus (Norway rat). ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. REFERENCE 1 (residues 1 to 405) AUTHORS Itoh,S., Okada,M. and Nakagawa,H. TITLE Isolation and characterization of a novel membrane-associated protein tyrosine phosphatase-like protein expressed preferentially in the central nervous system JOURNAL Unpublished COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D45413.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|302204340| COMMENT VNTNAME|rPTPBEM2_D1 (NP_598276)| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..279 /organism="Rattus norvegicus" /strain="W" /db_xref="taxon:10116" /chromosome="1" /map="1q12" /clone="BP18, BP22, BP32, BP33, BP181" /tissue_type="brain" /clone_lib="library of S.Nada" /dev_stage="neonate" /vntifkey="269" Protein 1..279 /product="brain-enriched membrane-associated protein tyrosine BEM-2" /vntifkey="270" Region 17..279 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 kdfadhvren ekdsncgfae eyqqlalegq gqsqmtalal envsknryrn vlpydwsrvp 61 lqplheepgs dyinasfmpg lwspkefiat qgplphtvsd fwrmvweqqs htlvmlancm 121 esgqvkcehy wpldaqpcth gqlqvtlvse evtenwtvrh lqlfhmkeqq tlsvrqfhyv 181 awpdhgvpys pdpllafqkl lrqwldqtmd ggppivhcsa gvgrtgtlia ldvllrqlec 241 eglvdpfsfv kkmresrplm vqteaqyvfl hqcilrslq // LOCUS rPTPbeta_D 280 aa 30-JUN-2003 DEFINITION similar to protein tyrosine phosphatase, receptor type, B; vascular endothelial protein tyrosine phosphatase [Mus musculus] [Rattus norvegicus]. ACCESSION XP_235156 DBSOURCE REFSEQ: accession XM_235156.1 SOURCE Rattus norvegicus (Norway rat). ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. COMMENT GENOME ANNOTATION REFSEQ: This model reference sequence was predicted from NCBI contig NW_044022 by automated computational analysis using gene prediction method: GenomeScan. Also see: Documentation of NCBI's Annotation Process COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|306790624| COMMENT VNTNAME|rPTPbeta_D1 (XP_235156 (revised))| COMMENT VNTAUTHORNAME|JNA| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|UNKNOWN| FEATURES Location/Qualifiers source 1..280 /organism="Rattus norvegicus" /strain="BN/SsNHsd/MCW" /db_xref="taxon:10116" /chromosome="7" /vntifkey="269" Protein 1..280 /product="similar to protein tyrosine phosphatase, receptor type, B; vascular endothelial protein tyrosine phosphatase [Mus musculus]" /vntifkey="270" ORIGIN 1 nqfeghfmkl qadsnyllsk eyedlkdvgr sqscdiallp enrgknrynn ilpydasrvk 61 lcnvdddpcs dyinasyipg nnfrreyiat qgplpgtkdd fwkmaweqnv hnivmvtqcv 121 ekgrvkcdhy wpadqdplyy gdlilqmvse svlpewtire fkicseeqld ahrllrhfhy 181 tvwpdhgvpe ttqsliqfvr tvrdyinrsp gagptvvhcs agvgrtgtfv aldrilqqld 241 skdsvdiyga vhdlrlhrvh mvqtecqyvy lhqcvrdvlr // LOCUS rPTPD2_D1\ 295 aa 30-JUN-2003 DEFINITION similar to protein tyrosine phosphatase, non-receptor type 14 [Mus musculus] [Rattus norvegicus]. ACCESSION XP_223062 DBSOURCE REFSEQ: accession XM_223062.1 SOURCE Rattus norvegicus (Norway rat). ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. COMMENT GENOME ANNOTATION REFSEQ: This model reference sequence was predicted from NCBI contig NW_042862 by automated computational analysis using gene prediction method: GenomeScan. Also see: Documentation of NCBI's Annotation Process COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|306792993| COMMENT VNTNAME|rPTPD2_D1 (XP_223062 (revised))| COMMENT VNTAUTHORNAME|JNA| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|UNKNOWN| FEATURES Location/Qualifiers source 1..295 /organism="Rattus norvegicus" /strain="BN/SsNHsd/MCW" /db_xref="taxon:10116" /chromosome="13" /vntifkey="269" Protein 1..295 /product="similar to protein tyrosine phosphatase, non-receptor type 14 [Mus musculus]" /vntifkey="270" Region 18..295 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" Region 41..295 /region_name="Protein tyrosine phosphatase [Signal transduction mechanisms]" /db_xref="CDD:COG5599" /vntifkey="266" /label=Region_2 /note="PTP2" Region 43..292 /region_name="Protein-tyrosine phosphatase" /db_xref="CDD:pfam00102" /vntifkey="266" /label=Region_3 /note="Y_phosphatase" Region 163..249 /region_name="Dual specificity phosphatase, catalytic domain" /db_xref="CDD:smart00195" /vntifkey="266" /label=Region_4 /note="DSPc" Region 163..249 /region_name="Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a 'recognition' region" /db_xref="CDD:pfam00782" /vntifkey="266" /label=Region_5 /note="DSPc" Region 178..292 /region_name="Protein tyrosine phosphatase, catalytic domain motif" /db_xref="CDD:smart00404" /vntifkey="266" /label=Region_6 /note="PTPc_motif" Region 187..249