LOCUS aotvoCD45\ 433 aa 17-MAY-2003 DEFINITION CD45 phosphatase [Aotus vociferans]. ACCESSION AAM48511 DBSOURCE locus AF364095S1 accession AF364095.1 SOURCE Aotus vociferans (noisy night monkey). ORGANISM Aotus vociferans Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Platyrrhini; Cebidae; Aotinae; Aotus. REFERENCE 1 (residues 1 to 433) AUTHORS Montoya,G.E., Vernot,J.P. and Patarroyo,M.E. TITLE Partial characterization of the CD45 phosphatase cDNA in the owl monkey Aotus vociferans JOURNAL Unpublished REFERENCE 2 (residues 1 to 433) AUTHORS Montoya,G.E., Vernot,J.P. and Patarroyo,M.E. TITLE Direct Submission JOURNAL Submitted (26-MAR-2001) Fisiologia Molecular, FIDIC, Avenida El Dorado, Carrera 50. INEA, Bogota, DC, Colombia COMMENT Method: conceptual translation. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|301970215| COMMENT VNTNAME|aotvoCD45 (AAM48511)_Fragm (5')| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..433 /organism="Aotus vociferans" /db_xref="taxon:57176" /vntifkey="269" Protein <1..>433 /product="CD45 phosphatase" /vntifkey="270" ORIGIN 1 rmmqrnggaa mchfttksap psqvwnmtvs mtsdnsmhvk crpprdrngp heryhlevea 61 gntlvrnesh kncdfrvkdl qystdytfka yfhngdypge pfilhhstsy nskaliafla 121 fliivtsial lvvlykiydl hkkrscnlde qqelverdde kqlmnvepih adilletykr 181 kiadegrlfl aefqsiprvf skfpikeark pfnqnknryv dilpydynrv elseingdag 241 snyinasyid gfkeprkyia aqgprdetvd dfwrmiweqk atvivmvtrc eegnrnkcae 301 ywpsveegtr afgdvvvkin qhkrcpdyii qklniinkke ktagrevthi qftswpdhgv 361 pedphlllkl rrrvnafsnf fxgpivvhcs agvgrtgtyi gidamlegle aenkvdvygy 421 vdklrrqrcl mvq // LOCUS aotvoCD45\ 365 aa 17-MAY-2003 DEFINITION CD45 phosphatase [Aotus vociferans]. ACCESSION AAM48512 DBSOURCE locus AF364095S2 accession AF364096.1 SOURCE Aotus vociferans (noisy night monkey). ORGANISM Aotus vociferans Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Platyrrhini; Cebidae; Aotinae; Aotus. REFERENCE 1 (residues 1 to 365) AUTHORS Montoya,G.E., Vernot,J.P. and Patarroyo,M.E. TITLE Partial characterization of the CD45 phosphatase cDNA in the owl monkey Aotus vociferans JOURNAL Unpublished REFERENCE 2 (residues 1 to 365) AUTHORS Montoya,G.E., Vernot,J.P. and Patarroyo,M.E. TITLE Direct Submission JOURNAL Submitted (26-MAR-2001) Fisiologia Molecular, FIDIC, Avenida El Dorado, Carrera 50. INEA, Bogota, DC, Colombia COMMENT Method: conceptual translation. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|301969998| COMMENT VNTNAME|aotvoCD45 (AAM48512)_Fragm (3')| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..365 /organism="Aotus vociferans" /db_xref="taxon:57176" /vntifkey="269" Protein <1..>365 /product="CD45 phosphatase" /vntifkey="270" ORIGIN 1 nmkkrdppse pspleaefqr lpsyrswrtq hignqeenks knrnsnvipy dfnrvplkhe 61 lemskesehd sdessdddsd seexskyina sfimxxwkpe vmiaaqgplx etigdfwqmi 121 fqrkvkvivm ltelkhgdqe icaqywgegk qtygdievdl kdtdksstyt lrvfelrhsk 181 rkdsrtvyqy qytnwsvxxl paxpkelism iqvxkqklpq knssegnkxh ksxpllihcr 241 dgsqqtgifc allnllesae teevvdxfqv vkalrkarpg mxstfeqxqf lydxiastyp 301 aqngqvkknn hqedkiefdn evdkvkqdan cvnplgapek lpeaneqaag septsgtegp 361 ehcvt // LOCUS bIA2\(P567 979 aa 17-MAY-2003 DEFINITION Protein-tyrosine phosphatase-like N precursor (R-PTP-N) (Islet cell autoantigen 512) (ICA512). ACCESSION P56722 DBSOURCE swissprot: locus PTPN_BOVIN, accession P56722; class: standard. created: May 30, 2000. sequence updated: May 30, 2000. annotation updated: Jun 15, 2002. xrefs: gi: 5305475, gi: 5305476 xrefs (non-sequence databases): HSSPQ06124, InterProIPR000387, InterProIPR000242, PfamPF00102, PRINTSPR00700, SMARTSM00194, PROSITEPS00383, PROSITEPS50056, PROSITEPS50055 KEYWORDS Receptor; Glycoprotein; Signal; Transmembrane. SOURCE Bos taurus (cow). ORGANISM Bos taurus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovoidea; Bovidae; Bovinae; Bos. REFERENCE 1 (residues 1 to 979) AUTHORS Hermel,J.-M., Dirkx,R. and Solimena,M. TITLE Direct Submission JOURNAL Submitted (~JUN-1999) REMARK SEQUENCE FROM N.A. REFERENCE 2 (residues 1 to 979) AUTHORS Hermel,J.M., Dirkx,R. Jr. and Solimena,M. TITLE Post-translational modifications of ICA512, a receptor tyrosine phosphatase-like protein of secretory granules JOURNAL Eur. J. Neurosci. 11 (8), 2609-2620 (1999) MEDLINE 99388259 REMARK SEQUENCE OF N-TERMINUS, AND CHARACTERIZATION. COMMENT ------------------------------------------------------------------- This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. The original entry is available from http://www.expasy.ch/sprot and http://www.ebi.ac.uk/sprot ------------------------------------------------------------------. [FUNCTION] Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Lacks intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2 (By similarity). [SUBUNIT] Interacts with phosphorylated SNTB2, protecting it from protein cleavage by CAPN1. Dephosphorylation of SNTB2 upon insulin stimulation disrupts the interaction and results in its cleavage (By similarity). [SUBCELLULAR LOCATION] Type I membrane protein. Neuroendocrine secretory granules. [PTM] N-glycosylated. [SIMILARITY] CONTAINS 1 PROTEIN-TYROSINE PHOSPHATASE DOMAIN. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|0| COMMENT VNTNAME|bIA2 (P56722) PTPRN| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..979 /organism="Bos taurus" /db_xref="taxon:9913" /vntifkey="269" Protein 1..979 /gene="PTPRN" /product="Protein-tyrosine phosphatase-like N precursor" /vntifkey="270" Region 1..34 /gene="PTPRN" /region_name="Signal" /vntifkey="200" /label=PTPRN Region 35..979 /gene="PTPRN" /region_name="Mature chain" /vntifkey="203" /label=PTPRN /note="PROTEIN-TYROSINE PHOSPHATASE-LIKE N." Region 35..575 /gene="PTPRN" /region_name="Domain" /vntifkey="1001" /label=PTPRN /note="EXTRACELLULAR (POTENTIAL)." Site 448..449 /gene="PTPRN" /site_type="cleavage" /vntifkey="221" /label=PTPRN /note="CLEAVAGE SITE." Site 0..0 /gene="PTPRN" /site_type="glycosylation" /vntifkey="238" /label=PTPRN /note="N-LINKED (GLCNAC...) (POTENTIAL)." Site 0..0 /gene="PTPRN" /site_type="glycosylation" /vntifkey="238" /label=PTPRN /note="N-LINKED (GLCNAC...) (POTENTIAL)." Region 576..600 /gene="PTPRN" /region_name="Transmembrane region" /vntifkey="210" /label=PTPRN /note="POTENTIAL." Region 601..979 /gene="PTPRN" /region_name="Domain" /vntifkey="1004" /label=PTPRN /note="CYTOPLASMIC (POTENTIAL)." Region 696..979 /gene="PTPRN" /region_name="Domain" /vntifkey="1000" /label=PTPRN /note="PROTEIN-TYROSINE PHOSPHATASE-LIKE." Site 0..0 /gene="PTPRN" /site_type="active" /vntifkey="220" /label=PTPRN /note="BY SIMILARITY." ORIGIN 1 mrlpgrpggp ggsgglrvll cllllgsrpg gcnaisahgc lfdrrlcshl evciqdglfg 61 qcqvgvgqar pllqvtspvl qrlqgvlrql msqglswhdd ltqyvisqem eriprlrppe 121 phprdrsglv prrpgpagel llqgiptgsa palqhrlprp svgggragag splsplqael 181 lppllehlll ppqpphpals yepallqpyl fhqfgsrdgs rgsesspgmv svdplpkaea 241 paflsragsk gmfgahpghs ygdppgpppa qlfqeselfy laqesqvpsr traprlpepg 301 gssragdsse gyeeeglegr eekppapaeq pdvtlqrvaa vlagygvelh qltpeqlstl 361 stllqllpkg srqnpggavn vgadikktme eqvqgedpae ppppmpslpg sptgsstsnk 421 aqkelstgas eppkaagppa tpvlvekksp lgqnqptmag qpstrpsaee ygyivtdqkp 481 lslaagvrll eilaehvhms sgsfinisvv gpaltfrirh neqnlsladv tqqaglvkse 541 leaqtglqil qtgvgqreea aailprpahs tspmrsvllt lvalagvagl lvalavalcv 601 rqharqrdke rlaalgpega hgdttfeyqd lcrqhmatks lfnraegppe psrvssvssq 661 fsdaaqasps shsstpswce epaqanmdis tghmilayme dhlrnrdrla kewqalcayq 721 aepntcataq gegnikknrh pdflpydhar iklkvessps rsdyinaspi iehdprmpay 781 iatqgplsht iadfwqmvwe sgctvivmlt plvedgvkqc drywpdegss lyhvyevnlv 841 sehiwcedfl vrsfylknvq tqetrtltqf hflswpaegt pastrplldf rrkvnkcyrg 901 rscpiivhcs dgagrtgtyi lidmvlnrma kgvkeidiaa tlehvrdqrp glvrskdqfe 961 faltavaeev nailkalpq // LOCUS bPTPBA14\( 2484 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 13 [APO-1/CD95 (Fas)-associated phosphatase] [Bos taurus]. ACCESSION NP_777015 DBSOURCE REFSEQ: accession NM_174590.1 SOURCE Bos taurus (cow). ORGANISM Bos taurus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovoidea; Bovidae; Bovinae; Bos. REFERENCE 1 (residues 1 to 2484) AUTHORS Vega,Q.C., Walton,K.M. and Dixon,J.E. TITLE Tyrosine Phosphatases and the Cytoskeleton JOURNAL Unpublished COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U20807.1. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|301945150| COMMENT VNTNAME|bPTPBA14 (NP_777015) PTPN13| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..2484 /organism="Bos taurus" /db_xref="taxon:9913" /chromosome="6" /map="6" /vntifkey="269" Protein 1..2484 /product="protein tyrosine phosphatase, non-receptor type 13 [APO-1/CD95 (Fas)-associated phosphatase]" /vntifkey="270" Region 572..781 /region_name="Band 4.1 homologues" /db_xref="CDD:smart00295" /vntifkey="266" /label=Region_1 /note="B41" Region 1090..1179 /region_name="Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides" /db_xref="CDD:smart00228" /vntifkey="1000" /label=Dom_Misc_1 /note="PDZ" Region 1366..1452 /region_name="Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides" /db_xref="CDD:smart00228" /vntifkey="1000" /label=Dom_Misc_2 /note="PDZ" Region 1496..1587 /region_name="Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides" /db_xref="CDD:smart00228" /vntifkey="1000" /label=Dom_Misc_3 /note="PDZ" Region 1787..1866 /region_name="Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides" /db_xref="CDD:smart00228" /vntifkey="1000" /label=Dom_Misc_4 /note="PDZ" Region 1882..1965 /region_name="Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides" /db_xref="CDD:smart00228" /vntifkey="1000" /label=Dom_Misc_5 /note="PDZ" Region 2213..2467 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_2 /note="PTPc" ORIGIN 1 mhvslaeale vrggplqeee iwavlnqsae slqelfrkvs iadpaalgfi ispwslllrs 61 gsvsftdeni snqdlrafta pevlqsqslt slsdvekihi yslgmtlywg adhevpqsqp 121 iklgdhlnsi llgmcedvvy arvsvrtvld acsahirnsn capsfsyvkq lvklvlgsls 181 gtdqlsrsse qkpdrsqair drlrgkglpt grsstsdvld tykspschqa flnkglsksm 241 gflsikdtrd eedyfkdlss dnnsgqedse sscspypfks sgpekkavpg ldvlpkkkiw 301 assmdllctg drdfssgetd ryqrrlpeav tvrtsttprk kearysdgsl aldifgpqkm 361 dpafhtrdlp tssaissald rirerqkklr vlreamnvee pvqryktyhs dlfstssesp 421 siissesdfr qvrksetskr fesnsglpgv detpsqgqsq rprqyetple gnlinqeiml 481 krqeeemmql qarmalrqsr lslypgdtik asmlditrdp lreialetam tqrklrnffg 541 pefvkmtiep fisldlprsi ltkkgksedn rrkvnimlls gqrleltcdt ktickdvfdm 601 vvahiglveh hlfalatlkd neyffvdsdl kltkvapegw keepkkkska sinftlffri 661 kffmddvsli qhtltchqyy lqlrkdtlee rihcddetsl llaslalqae ygdyqpevhg 721 vsyfrlehyl pprvmekldl syikeelpkl hntymgasek eteleflkvc qrlteygvhf 781 hrvhpekksq tgillgvcsk gvlvfevhng vrtlvlrfpw retkkisfsk kkitlqntsd 841 gikhafqtdn skicqyllhl cssqhkfqlq mrarqsnqda qdierasfrs lnfqaesvrg 901 fnmgravstg slasstlnkl avrplsvqae ilkrlscsel slcqplqnsa kekngktawe 961 ekprgmsksy hdlsqaclyp hrknvnvnme pppqtiaelv gktlhqmars dteslagvtk 1021 lnnsksvasl nrsperrkhe sdsssfedlg qayvlgmtlh ssgnsssqvp lkendvlhkr 1081 wsiasspere itlvnlkkda qyglgfqiig gekmgrldlg vfissvtpgg padldgclkp 1141 gdrlisvnsv slegvshhaa veilqnaped vtlvisqpke klskvpstpv hmangtknym 1201 kkpshlqdgt vnssedhcwp rgtprhises sfglsgglre gslssqdsrt esaslsqsqv 1261 ngffashaad rswqdsqrgs pspsviskat ekkwtstdsn rskakntgis dapdysdrgd 1321 sdmdeatyss sqdhhipkke ssssmntsnk mnfktfpssp pkpgdifeve lakndnslgi 1381 svtggvntsv rhggiyvkav ipkgaaesdg rihkgdrvla vngvslegat hkqavetlrn 1441 tgqvvhllle kgqspaskeh vlqctvsdpd tqgqapekmm tkmthvkdys fvteentfev 1501 kllknssglg fsfsrednvi peqmntsivr vkklfpgqpa aesgqidvgd vilkvngasl 1561 kglsqqevis alrgtspevs lllcrpppgv lpeidpalst plhspaqvpl nnskdppqta 1621 caeqgtssde nemsdknrrp ctspsrrdsy sdssesgedd lakapakipn mswssalqqt 1681 lsnmmsqaqs hhdtlrsqed pictmfyypq kvpnkpeheg snplpprpld vtpgqscqsq 1741 sesvpinamd kyhthhtsep trqesltslk ndlenhledf elevellitl hksekgslgf 1801 tvtkgnqsig cyvhdviqdp aksdgrlrpg drlikvndtd vtnmthtdav nllrraprtv 1861 rlvlgrvlel prmpvlphll pditftcnre elgfslsggr dslhqvvyvs dinprsiaat 1921 egnlqlldvi hyvngvstqg mtleeakrtl dmslpsvvlk atrdghpvvp sskgsalsas 1981 ksakangphi vepcgkpslt pnnsfskvng eeiieilype gkcstyqmke sanlilykes 2041 dgqedenydd pqeaeviqsl ldvvdeeaqn llnqnnvagd acvpgalkan eklseeraqd 2101 tycdgsplpe dftestkmng ceehceekgk sesliqksee kkteddeitw gsdelpiett 2161 dhedsnkehp fltneelttl piikvlpsgk ytgaklksvi rmlrglldqg ipskelenlq 2221 elkpldqcli gqtkenrrkn ryknilpyda trvplgdegg yinasfikip vgreefvyia 2281 cqgplpttvg dfwqmiweqn ssviammtqe vegekikcqr ywpnvlgkst mvsnrlrlal 2341 vrvqqlkgfv vramtlediq tgevrhvshl nftawpdhdt psqpddlltf isymrhvhrs 2401 gpiithcsag igrsgtlici dvvlglisqd lefdisdlvr cmrlqrhgmv qtedqyifcy 2461 qvilyvltrl qaeeeqkeqp qplk // LOCUS cCD45\(A54 1237 aa 17-MAY-2003 DEFINITION protein-tyrosine-phosphatase (EC 3.1.3.48), receptor type delta precursor - chicken. ACCESSION A54080 DBSOURCE pir: locus A54080; summary: #length 1237 #molecular-weight 139319 #checksum 1986 ; superfamily: leukocyte common antigen; leukocyte common antigen cytosolic domain homology; protein-tyrosine-phosphatase homology ; PIR dates: 02-Aug-1994 #sequence_revision 02-Aug-1994 #text_change 21-Jan-2000 . KEYWORDS phosphoprotein; phosphoric monoester hydrolase; tyrosine-specific phosphatase. SOURCE Gallus gallus (chicken). ORGANISM Gallus gallus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. REFERENCE 1 (residues 1 to 1237) AUTHORS Fang,K.S., Barker,K., Sudol,M. and Hanafusa,H. TITLE A transmembrane protein-tyrosine phosphatase contains spectrin-like repeats in its extracellular domain JOURNAL J. Biol. Chem. 269 (19), 14056-14063 (1994) MEDLINE 94245724 COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|301941064| COMMENT VNTNAME|cCD45 (A54080)| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..1237 /organism="Gallus gallus" /db_xref="taxon:9031" /vntifkey="269" Protein 1..1237 /product="protein-tyrosine-phosphatase, receptor type delta precursor" /EC_number="3.1.3.48" /vntifkey="270" Region 528..1170 /region_name="domain" /vntifkey="1000" /label=LAC /note="leukocyte common antigen cytosolic domain homology #label LAC" Region 610..834 /region_name="domain" /vntifkey="1000" /label=PTP /note="protein-tyrosine-phosphatase homology #label PTP" Site 0..0 /site_type="active" /vntifkey="220" /label=Active_Site_1 /note="Cys (phosphocysteine intermediate)" Site 0..0 /site_type="binding" /vntifkey="1007" /label=Binding_1 /note="substrate phosphate (Arg)" ORIGIN 1 mflclkllaf gvaflcqdaf aqagndnlts asslsstlpt ptrstsfspp sttagvqpas 61 tgasptasth lsthsgsgpt tglghlqhss paalttrtlt afhqtvsdyy sstslhntts 121 pvitpastet iptstiesat tteepcdnsi dygnieeknn saevtlknlk enriydille 181 dgkslsvnas nnivmlnwcr rytvqsrsck vmyltippde krytfgaksi gndnatlrln 241 slcidcedvc snvtvscktn sinsggtgnl tgsyelmkhd inadnitils lssdseylcr 301 vtvrffeknf tkevnittdy dapkapenlt vhptdrnvtv twmkptgtle khidgytvec 361 nntsqnvnrn etsftcgdle pystgsvsvr afkkskyknk nfegekvngs fqtkpakpen 421 vtdfkltlla dntvkvacrs qkvygnetkf klswnsssns genqrknecn ftvrdlsylt 481 kytfkisvfn gvytgdsvce eiytrynsra liiflvfliv vtsialllvl ykiydlhqkk 541 lsnssevisl vavkdderql lniepipsek lletykrkia degrlfldef qsipriftkf 601 pmkeakrshn qnknryidil pydhnrvels eipgdpgsdy inasyidgfk eprkyiaaqg 661 pkdettddfw rmiweqkati ivmvtrceeg nrnkcaqygp smengsatyg ditvkinesk 721 icpdyiiqkl hitngrerts grdvthiqft swpdhgvped phlllklrrr vnalsnffsg 781 pivvhcsagv grtgtyigid amlegldaeg rvdvygyvvk lrrqrclmvq vesqyilihq 841 alveyhqyge tevslselhs ylnnlkrkdp psepslleak fqrlpsykgw rtqntgnree 901 nknknrsant ipydfnrvpi rseeeqskeg ehdsedssde dsdceessry inasfitgyw 961 gpkamiatqg plqetisdfw qmvfqrkvkv ivmltelkeg dqelcaqywg egrqtyddie 1021 vqvtdvnccp sytirafdvt hlkrketqkv yqyqyhkwng ldvpedpkdl vdmilslkqk 1081 vpsrpaseds rnsrsvpfvi hccdgsqqtw cvlclmtlle saeteevidv fqvvkalrrs 1141 rlgvvstfeq yqflydtiar typaqngqik nihqedkvef cnevekkdqe sdlitidltp 1201 stpeendape ccddfkaadt nkgtesstng pttpvlt // LOCUS cDEP1\(CAB 1406 aa 17-MAY-2003 DEFINITION supporting-cell antigen [Gallus gallus]. ACCESSION CAB41885 DBSOURCE embl locus GGA238216, accession AJ238216.2 SOURCE Gallus gallus (chicken). ORGANISM Gallus gallus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. REFERENCE 1 AUTHORS Kruger,R.P., Goodyear,R.J., Legan,P.K., Warchol,M.E., Raphael,Y., Cotanche,D.A. and Richardson,G.P. TITLE The supporting-cell antigen: a receptor-like protein tyrosine phosphatase expressed in the sensory epithelia of the avian inner ear JOURNAL J. Neurosci. 19 (12), 4815-4827 (1999) MEDLINE 99296852 REFERENCE 2 AUTHORS Legan,P.K. TITLE Direct Submission JOURNAL Submitted (26-APR-1999) Legan P.K., School of Biological Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UNITED KINGDOM REMARK Revised by [3] REFERENCE 3 (residues 1 to 1406) AUTHORS Legan,P.K. TITLE Direct Submission JOURNAL Submitted (27-JUN-2001) Legan P.K., School of Biological Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UNITED KINGDOM COMMENT On Jun 28, 2001 this sequence version replaced gi:4741401. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|0| COMMENT VNTNAME|cDEP1 (CAB41885)| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..1406 /organism="Gallus gallus" /db_xref="taxon:9031" /tissue_type="intestine" /clone_lib="lambda ZAP II" /dev_stage="2 day posthatch" /country="United Kingdom" /vntifkey="269" Protein 1..1406 /product="supporting-cell antigen" /function="putative receptor protein tyrosine phosphatase" /vntifkey="270" Region 1..24 /vntifkey="200" /label=Signal_1 ORIGIN 1 mrrlpllppc plllllllpa evrcttactd dcslknvtee mgtssndels vnatsgnrrl 61 sedvslpgra msdqnsvaqp ravldlktey vgvtsvnltw tvndtasdsy tyrievrngs 121 sinnktsdit daeitglipg tlytftvfav aadgqtageg asislytkps pvldlkaeyv 181 gvtsvnltwt vndtasasyt yrievtsdss idsltssvtm aeitglipgt lysfkvfava 241 adnrteadga sislytkpsp vldlkaeyvg vtsvnltwtv ngtaltayty rievrnatsi 301 rnetsninki eitglipgts ynfkvfatpv nntteeegls lnlytkpspv lrvvteyvgv 361 tsvnltwmvd dtasdsytyr ievrngssin nktsditdae itglipgtly tftvfavaad 421 gqtagegasi slytkpspvl dlkaeyvgvt svnltwtvnd tasasytyri evtsdssids 481 ltsnvtmaei tglipgtlyn ftvfavaadn rteadgafts lytkptpvtd lkaehgvtsv 541 slnwmvndta sdsytyriev rnghsvnnkt snipeteitg lnpgtlytft vfavaadget 601 egegasisvy tkpravlhlk teyvgvtsvn ltwtvndtds asytyrievr ngssinnkts 661 ditdaeitgl dpgtlyiftv favaadgqta gegasislyt kpsmvlnlka eyvtmtsvnl 721 twmvndaesa sytyrievah eslinetmsn vtksivtyli pgtsynftvf aiaadnqteg 781 egasisqntv pssvnafqce avanmsyltl kwncpyggys gfdieifngt wtkkqqsqfc 841 gregseeifk tepldyykty tvsvttvsdg ltslpvqkic ktsitdppvp nkaplvkavs 901 hnslsvefpd fesvngplka yavmivteae gclpsksdld ytyndfkqkm tatyvtyvid 961 veeisssshs qnghnivdvg kgntmygyen gpliplhsyr asvagftnin ftvankimge 1021 qsyvsfspcs evvslpqdpg viagavigcl lailavvaig gyifwrrrrk dkrntevsfs 1081 pikikkskmi kvenfesyfk kqqadsncgf aeeyeelksa gvhqpkfaae iaenrgknry 1141 nnvlpydisr vklsnpsctt ddyinanymp gysskkafia aqgplpntie dfwrmiwekn 1201 iysivmltkc veqartkceq ywpdkqsksy gdiivtmvse vvlpewtird fnvenadtme 1261 shtvrqfhft swpdhgvpet tdllinfrhl vheyssqnpi dspilvhcsa gvgrtgtfia 1321 idrliqqiem entvdvygvv ydlrmhrplm vqtedqyvfl nqcvmdiirs qkekktdliy 1381 qnttamaiye nftpgpafgk angyha // LOCUS cGLEPP1\(A 1267 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase CRYP-2 [Gallus gallus]. ACCESSION AAB17968 DBSOURCE locus GGU65891 accession U65891.1 SOURCE Gallus gallus (chicken). ORGANISM Gallus gallus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. REFERENCE 1 (residues 1 to 1267) AUTHORS Bodden,K. and Bixby,J.L. TITLE CRYP-2: a receptor-type tyrosine phosphatase selectively expressed by developing vertebrate neurons JOURNAL J. Neurobiol. 31 (3), 309-324 (1996) MEDLINE 97067376 REFERENCE 2 (residues 1 to 1267) AUTHORS Bodden,K. and Bixby,J.L. TITLE Direct Submission JOURNAL Submitted (01-AUG-1996) Pharmacology, University of Miami, 1600 NW 10 Ave, Miami, FL 33136, USA COMMENT Method: conceptual translation. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|0| COMMENT VNTNAME|cGLEPP1 (AAB17968)| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..1267 /organism="Gallus gallus" /db_xref="taxon:9031" /tissue_type="brain" /vntifkey="269" Protein 1..1267 /product="protein tyrosine phosphatase CRYP-2" /vntifkey="270" ORIGIN 1 mlpqfaiagh asepgggrrg aaargrgaee pqppppgrsr grgrraprcp taaggarggp 61 garscllwlf vllknaepfq vtvqednciv vsleasdvvs sssvyvvkia gesknyffqf 121 eefnstlpap vifnakyhgl yyivtllvvn snmvsksars itvltkplpv ssvsiydykp 181 spetgvlfei qypekynvft rvnisywegk dyrtmlykdf fkgktvfnhw lpgicysnit 241 fqlvseatfn kstlveysgv rhepkqhrtv pypprnisvq ivpinrnnwe ehsgnfaees 301 fmgqqeiisk eklsrfpsdp peipvvntta awpdyrsnst eyettsqpyw wsneaesseg 361 eeefvnavpr dygaseanas gkltaepapf lpvqmvltwl ppkpptafdg fhiniereen 421 stelltvsed thkfvaelke pgkyklsvtt fsssgscevr gsqsaktlsf yisptgewie 481 eltekpqhvt vtvlssttal tswtashesg sngtivsvvs ltcqkqkesq rlekhyctev 541 nsssslienl vpgaqyqvvv ylrkgplvgp psdpvtfsiv ptgikdltly plgptavvls 601 wnrpflgvfr kyvvemfyfn pstmtsewtt yyeiaatisl tasvrianll pawyynfrvt 661 mvtwgdpels ccdsstisfi tapvapeits ieyynhllyv twtyggdgtd lshsrmlhwm 721 viaegkkkik ksvtrsvmta vlslppgdiy nlsvtacter gsntslpqlv klepappksl 781 favnktqtsv tllwveegva dffevycqqa gsnqevkvqe pvtvsshvvt issltpatsy 841 ncsvttfshn spsvptyiav stmvtemnpn ivvisvlail silliglllv tlvvlrrkhl 901 qmarecgagt fvnfaslerd gklpynwrrs vfafltllps clwtdyllaf yinpwskngl 961 kkrkltnpvq lddfdgyikd makdsdykfs lqfeelklig ldiphfaadl pmnrcknryt 1021 nilpydfsrv rlvsmneeeg sdyinanyip gynspqeyia tqgplpetrn dfwkmvlqqk 1081 sqiivmltqc nekrrvkcdh ywpftedpia ygditvemls eeehtdwvyr nfrisyadev 1141 qdvmhfnyta wpdhgvptan aaesilqfvq mvrqksvksk gpmiihcsag vgrtgtfial 1201 dwllqhirdh efvdilglvs dmrsyrmsmv qteeqyifih qcvqlmwqkk kqqfcisdvi 1261 yenvsks // LOCUS cMG-PTP1\( 81 aa 17-MAY-2003 DEFINITION Muller glia protein tyrosine phosphatase 1, MG-PTP1 [chickens, retinas, Muller glia cells, Peptide Partial, 81 aa]. ACCESSION AAB33980 DBSOURCE accession AAB33980.1 SOURCE Gallus gallus (chicken). ORGANISM Gallus gallus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. REFERENCE 1 (residues 1 to 81) AUTHORS Shock,L.P., Bare,D.J., Klinz,S.G. and Maness,P.F. TITLE Protein tyrosine phosphatases expressed in developing brain and retinal Muller glia JOURNAL Brain Res. Mol. Brain Res. 28 (1), 110-116 (1995) MEDLINE 95223107 REMARK GenBank staff at the National Library of Medicine created this entry [NCBI gibbsq 165661] from the original journal article. This sequence comes from Fig. 2C. COMMENT Method: conceptual translation supplied by author. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|0| COMMENT VNTNAME|cMG-PTP1 (AAB33980)_Fragm| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..81 /organism="Gallus gallus" /db_xref="taxon:9031" /vntifkey="269" Protein 1..81 /partial /product="Muller glia protein tyrosine phosphatase 1" /vntifkey="270" /note="MG-PTP1" ORIGIN 1 grgtdtygmi qvtlldtiel atfcvrtfsl hkngsskkre vrqfqftawp dhgvpeyptp 61 flaflrrvkt cnppdagpiv v // LOCUS cMG-PTP2\( 87 aa 17-MAY-2003 DEFINITION Muller glia protein tyrosine phosphatase 2, MG-PTP2 {MG-PTP2 catalytic domain} [chickens, retinas, Muller glia cells, Peptide Partial, 87 aa]. ACCESSION AAB33981 DBSOURCE accession AAB33981.1 SOURCE Gallus gallus (chicken). ORGANISM Gallus gallus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. REFERENCE 1 (residues 1 to 87) AUTHORS Shock,L.P., Bare,D.J., Klinz,S.G. and Maness,P.F. TITLE Protein tyrosine phosphatases expressed in developing brain and retinal Muller glia JOURNAL Brain Res. Mol. Brain Res. 28 (1), 110-116 (1995) MEDLINE 95223107 REMARK GenBank staff at the National Library of Medicine created this entry [NCBI gibbsq 165663] from the original journal article. This sequence comes from Fig. 2D. COMMENT Method: conceptual translation supplied by author. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|0| COMMENT VNTNAME|cMG-PTP2 (AAB33981)_Fragm| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..87 /organism="Gallus gallus" /db_xref="taxon:9031" /vntifkey="269" Protein 1..87 /partial /product="Muller glia protein tyrosine phosphatase 2" /vntifkey="270" /note="MG-PTP2" ORIGIN 1 trgeevmvfs etgfrvrlvs ediksyytvh llqleninsg esrmishfhy ttwpdfgvpe 61 spasflnflf kvresgclsp ehgpavd // LOCUS cPTP-NT1su 62 aa 28-JUN-2003 DEFINITION phosphoprotein phosphatase. ACCESSION AAA49018 DBSOURCE locus CHKPHOSPHC accession L20630.1 SOURCE Gallus gallus (chicken). ORGANISM Gallus gallus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. REFERENCE 1 (residues 1 to 62) AUTHORS Potts,J.D. TITLE Protein tyrosine phosphatases isolated from embryonic chicken lens epithelium JOURNAL Unpublished (1993) COMMENT Method: conceptual translation. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|306551667| COMMENT VNTNAME|cPTP-NT1subtype (AAA49018) Fragm| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..62 /organism="Gallus gallus" /sub_species="domesticus" /db_xref="taxon:9031" /cell_type="epithelial cell" /tissue_type="lens" /dev_stage="embryo" /vntifkey="269" Protein 1..62 /product="phosphoprotein phosphatase" /vntifkey="270" ORIGIN 1 gsdyinasli kmeeaqrsyi ltqgplpntc ghfwemvweq ksrgvvmlnr vmekgsikcd 61 qy // LOCUS cPTP-NT1su 63 aa 17-MAY-2003 DEFINITION phosphoprotein phosphatase. ACCESSION AAA49019 DBSOURCE locus CHKPHOSPHD accession L20631.1 SOURCE Gallus gallus (chicken). ORGANISM Gallus gallus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. REFERENCE 1 (residues 1 to 63) AUTHORS Potts,J.D. TITLE Protein tyrosine phosphatases isolated from embryonic chicken lens epithelium JOURNAL Unpublished (1993) COMMENT Method: conceptual translation. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|0| COMMENT VNTNAME|cPTP-NT1subtype (AAA49019)_Fragm| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..63 /organism="Gallus gallus" /sub_species="domesticus" /db_xref="taxon:9031" /cell_type="epithelial cell" /tissue_type="lens" /dev_stage="embryo" /vntifkey="269" Protein 1..63 /product="phosphoprotein phosphatase" /vntifkey="270" ORIGIN 1 gsdyinaslv vieeaqryyi ltqgplpntc chfwlmvwqq qtkavvmlnr ivekdsvkca 61 qyw // LOCUS cPTP-R2Asu 63 aa 17-MAY-2003 DEFINITION phosphoprotein phosphatase. ACCESSION AAA49017 DBSOURCE locus CHKPHOSPHB accession L20629.1 SOURCE Gallus gallus (chicken). ORGANISM Gallus gallus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. REFERENCE 1 (residues 1 to 63) AUTHORS Potts,J.D. TITLE Protein tyrosine phosphatases isolated from embryonic chicken lens epithelium JOURNAL Unpublished (1993) COMMENT Method: conceptual translation. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|0| COMMENT VNTNAME|cPTP-R2Asubtype (AAA49017)_Fragm| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..63 /organism="Gallus gallus" /sub_species="domesticus" /db_xref="taxon:9031" /cell_type="epithelial cell" /tissue_type="lens" /dev_stage="embryo" /vntifkey="269" Protein 1..63 /product="phosphoprotein phosphatase" /vntifkey="270" ORIGIN 1 gsdyinassi dgyrqqkayi atqgplaett edfwwmlwen nstivvmltk lremgrekca 61 qyw // LOCUS cPTP-R2Bsu 63 aa 17-MAY-2003 DEFINITION phosphoprotein phosphatase. ACCESSION AAA49016 DBSOURCE locus CHKPHOSPHA accession L20504.1 SOURCE Gallus gallus (chicken). ORGANISM Gallus gallus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. REFERENCE 1 (residues 1 to 63) AUTHORS Potts,J.D. TITLE Protein tyrosine phosphatases isolated from embryonic chicken lens epithelium JOURNAL Unpublished (1993) COMMENT Method: conceptual translation. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|0| COMMENT VNTNAME|cPTP-R2Bsubtype (AAA49016)_Fragm| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..63 /organism="Gallus gallus" /sub_species="domesticus" /db_xref="taxon:9031" /cell_type="epithelial cell" /tissue_type="lens" /dev_stage="embryo" /vntifkey="269" Protein 1..63 /product="phosphoprotein phosphatase" /vntifkey="270" ORIGIN 1 gsdymnanyi dgyhrsnhfi atqgpkqemv ydfwrmvwqe hcssivmitk lvevgrvkca 61 qyw // LOCUS cPTP1B\(O1 434 aa 17-MAY-2003 DEFINITION Protein-tyrosine phosphatase, non-receptor type 1 (Protein-tyrosine phosphatase 1B) (PTP-1B) (CPTP1). ACCESSION O13016 DBSOURCE swissprot: locus PTN1_CHICK, accession O13016; class: standard. extra accessions:Q90704,created: Dec 15, 1998. sequence updated: Dec 15, 1998. annotation updated: Oct 16, 2001. xrefs: gi: 2058554, gi: 2058555, gi: 1209884, gi: 1209885 xrefs (non-sequence databases): HSSPP18031, InterProIPR000387, InterProIPR000242, PfamPF00102, PRINTSPR00700, SMARTSM00194, PROSITEPS00383, PROSITEPS50056, PROSITEPS50055 KEYWORDS Hydrolase. SOURCE Gallus gallus (chicken). ORGANISM Gallus gallus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. REFERENCE 1 (residues 1 to 434) AUTHORS Balsamo,J., Leung,T., Ernst,H., Zanin,M.K., Hoffman,S. and Lilien,J. TITLE Regulated binding of PTP1B-like phosphatase to N-cadherin: control of cadherin-mediated adhesion by dephosphorylation of beta-catenin JOURNAL J. Cell Biol. 134 (3), 801-813 (1996) MEDLINE 96326683 REMARK SEQUENCE FROM N.A. TISSUE=Retina REFERENCE 2 (residues 1 to 434) AUTHORS Kim,C.W., Jung,E.J. and Kang,Y.-S. TITLE Cloning and characterization of a chicken protein tyrosine phosphatase, CPTP1 JOURNAL Exp. Mol. Med. 28, 207-213 (1996) REMARK SEQUENCE OF 14-369 FROM N.A. TISSUE=Intestine COMMENT ------------------------------------------------------------------- This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. The original entry is available from http://www.expasy.ch/sprot and http://www.ebi.ac.uk/sprot ------------------------------------------------------------------. [CATALYTIC ACTIVITY] PROTEIN TYROSINE PHOSPHATE + H(2)O = PROTEIN TYROSINE + ORTHOPHOSPHATE. [SUBCELLULAR LOCATION] ASSOCIATED TO THE ENDOPLASMIC RETICULUM VIA ITS C-TERMINAL DOMAIN WITH ITS PHOSPHATASE DOMAIN ORIENTED TOWARDS THE CYTOPLASM (BY SIMILARITY). [SIMILARITY] BELONGS TO THE NON-RECEPTOR CLASS OF THE PROTEIN-TYROSINE PHOSPHATASE FAMILY. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|0| COMMENT VNTNAME|cPTP1B (O13016)| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..434 /organism="Gallus gallus" /db_xref="taxon:9031" /vntifkey="269" Protein 1..434 /gene="PTPN1" /product="Protein-tyrosine phosphatase, non-receptor type 1" /EC_number="3.1.3.48" /vntifkey="270" Region 0..0 /gene="PTPN1" /region_name="Conflict" /vntifkey="240" /label=PTPN1 /note="A -> R (IN REF. 2)." Region 40..288 /gene="PTPN1" /region_name="Domain" /vntifkey="1000" /label=PTPN1 /note="PROTEIN-TYROSINE PHOSPHATASE." Region 62..63 /gene="PTPN1" /region_name="Conflict" /vntifkey="240" /label=PTPN1 /note="GD -> RC (IN REF. 2)." Site 0..0 /gene="PTPN1" /site_type="active" /vntifkey="220" /label=PTPN1 ORIGIN 1 meiekefhrl dqaaswaaiy qdirheasdf pckvakhprn knrnryrdvs pfdhsrikln 61 qgdndyinas likmeeaqrs yiltqgplpn tcghfwemvw eqksrgvvml nrvmekgsik 121 caqywprkee kemffedtnl kltlisedik syytvrqlel enlttqetre ilhfhyttwp 181 dfgvpespas flnflfkvre sgslnpeygp vvvhcsagig rsgtfclvdt clllmdkrkd 241 pssvdvkqvl lemrkyrmgl iqtadqlrfs ylaviegakf imgdasvqeq wkelsnedld 301 pppehtpppp rppkrtsemh ngrmhehaef fpkhqvveee ircsvstaee tvsdgrvfss 361 vplitdstsq dteirrrtvg enlhvtahke esksesveed denmmttwkp flvnicmftf 421 ltagaylcyr vcfh // LOCUS cPTPalpha\ 807 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase. ACCESSION AAB04150 DBSOURCE locus CHKPTPA accession L22437.1 SOURCE Gallus gallus (chicken). ORGANISM Gallus gallus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. REFERENCE 1 (residues 1 to 807) AUTHORS Fang,K.S. TITLE Structural and functional characterization of two chicken tyrosine phosphatases JOURNAL Thesis (1993) COMMENT Method: conceptual translation. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|0| COMMENT VNTNAME|cPTPalpha (AAB04150)| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..807 /organism="Gallus gallus" /sub_species="domesticus" /db_xref="taxon:9031" /tissue_type="brain" /dev_stage="E10" /vntifkey="269" Protein 1..807 /product="protein tyrosine phosphatase" /vntifkey="270" Region 1..20 /vntifkey="200" /label=Signal_1 Region 21..807 /product="protein tyrosine phosphatase" /vntifkey="203" /label=Chain_1 ORIGIN 1 mdlwffvlll gsglisvgat nvtteppttv ptstriptka ptaapdggtt prvsslnvss 61 pmttsapase pptttatsis pnattaslna stpgtsvpts apvaislpps atpsalltal 121 psteaemter nvsatvttqe tssashngns drrdetpiia vmvalssllv ivfiiivlym 181 lrfkkykqag shsnsfrlpn grtddaepqs mpllarspst nrkypplpvd kleeeinrri 241 gddnklfree fnalpacpiq atceaaskee nkeknryvni lpydhsrvhl tpvegvpdsh 301 yintsfinsy qeknkfiaaq gpkeetvndf wrmiweqnta tivmvtnlke rkeckcaqyw 361 pdqgcwtygn irvsvedvtv lvdytvrkfc iqqvgdvtnk kpqrlvtqfh ftswpdfgvp 421 ftpigmlkfl kkvktcnpqy agaivvhcsa gvgrtgtfiv idamldmmha erkvdvygfv 481 sriraqrcqm vqtdmqyvfi yqallehyly gdtelevtsl eihlqkiynk vpgtssngle 541 eefkkltsik iqndkmrtgn lpanmkknrv lqiipyefnr viipvkrgee ntdyvnasfi 601 dgyrrrtptc qprpvqhtie dfwrmiwewk scsivmltel eergqekcaq ywpsdgsvsy 661 gdinvelkke eecesytvrd llvtntrenk srqirqfhfh gwpevgipsd gkgminiiaa 721 vqkqqqqsgn hpmhchcsag agrtgtfcal stvlervkae gildvfqtvk slrlqrphmv 781 qtleqyefcy kvvqeyidaf sdyanfk // LOCUS cPTPgamma\ 1422 aa 17-MAY-2003 DEFINITION Protein-tyrosine phosphatase gamma precursor (R-PTP-gamma). ACCESSION Q98936 DBSOURCE swissprot: locus PTPG_CHICK, accession Q98936; class: standard. created: Jul 15, 1999. sequence updated: Jul 15, 1999. annotation updated: Jun 15, 2002. xrefs: gi: 1617477, gi: 1617478 xrefs (non-sequence databases): HSSPP18052, InterProIPR001148, InterProIPR003961, InterProIPR000387, InterProIPR000242, PfamPF00041, PfamPF00102, PfamPF00194, PRINTSPR00700, ProDomPD000865, SMARTSM00060, SMARTSM00194, PROSITEPS00383, PROSITEPS50056, PROSITEPS50055 KEYWORDS Glycoprotein; Transmembrane; Hydrolase; Repeat; Signal. SOURCE Gallus gallus (chicken). ORGANISM Gallus gallus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. REFERENCE 1 (residues 1 to 1422) AUTHORS Qinghua,X., Xiaojun,G., Cong,S., Zong,S.M., Jong,Y.J., Chan,J. and Wang,L.-H. TITLE Direct Submission JOURNAL Submitted (~OCT-1995) REMARK SEQUENCE FROM N.A. TISSUE=Brain, and Kidney COMMENT ------------------------------------------------------------------- This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. The original entry is available from http://www.expasy.ch/sprot and http://www.ebi.ac.uk/sprot ------------------------------------------------------------------. [CATALYTIC ACTIVITY] Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. [SUBCELLULAR LOCATION] Type I membrane protein (Probable). [SIMILARITY] IN THE N-TERMINAL SECTION; BELONGS TO THE EUKARYOTIC-TYPE CARBONIC ANHYDRASE FAMILY. [SIMILARITY] CONTAINS 2 PROTEIN-TYROSINE PHOSPHATASE DOMAINS. [SIMILARITY] CONTAINS 1 FIBRONECTIN TYPE III-LIKE DOMAIN. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|0| COMMENT VNTNAME|cPTPgamma (Q98936)| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..1422 /organism="Gallus gallus" /db_xref="taxon:9031" /vntifkey="269" Protein 1..1422 /gene="PTPRG" /product="Protein-tyrosine phosphatase gamma precursor" /EC_number="3.1.3.48" /vntifkey="270" Region 1..19 /gene="PTPRG" /region_name="Signal" /vntifkey="200" /label=PTPRG /note="BY SIMILARITY." Region 20..1422 /gene="PTPRG" /region_name="Mature chain" /vntifkey="203" /label=PTPRG /note="PROTEIN-TYROSINE PHOSPHATASE GAMMA." Region 20..742 /gene="PTPRG" /region_name="Domain" /vntifkey="1001" /label=PTPRG /note="EXTRACELLULAR (POTENTIAL)." Region 56..322 /gene="PTPRG" /region_name="Domain" /vntifkey="1000" /label=PTPRG /note="CARBONIC-ANHYDRASE LIKE." Site 0..0 /gene="PTPRG" /site_type="glycosylation" /vntifkey="238" /label=PTPRG /note="N-LINKED (GLCNAC...) (POTENTIAL)." Site 0..0 /gene="PTPRG" /site_type="glycosylation" /vntifkey="238" /label=PTPRG /note="N-LINKED (GLCNAC...) (POTENTIAL)." Site 0..0 /gene="PTPRG" /site_type="glycosylation" /vntifkey="238" /label=PTPRG /note="N-LINKED (GLCNAC...) (POTENTIAL)." Region 347..441 /gene="PTPRG" /region_name="Domain" /vntifkey="1018" /label=PTPRG /note="FIBRONECTIN TYPE-III." Site 0..0 /gene="PTPRG" /site_type="glycosylation" /vntifkey="238" /label=PTPRG /note="N-LINKED (GLCNAC...) (POTENTIAL)." Site 0..0 /gene="PTPRG" /site_type="glycosylation" /vntifkey="238" /label=PTPRG /note="N-LINKED (GLCNAC...) (POTENTIAL)." Site 0..0 /gene="PTPRG" /site_type="glycosylation" /vntifkey="238" /label=PTPRG /note="N-LINKED (GLCNAC...) (POTENTIAL)." Site 0..0 /gene="PTPRG" /site_type="glycosylation" /vntifkey="238" /label=PTPRG /note="N-LINKED (GLCNAC...) (POTENTIAL)." Site 0..0 /gene="PTPRG" /site_type="glycosylation" /vntifkey="238" /label=PTPRG /note="N-LINKED (GLCNAC...) (POTENTIAL)." Site 0..0 /gene="PTPRG" /site_type="glycosylation" /vntifkey="238" /label=PTPRG /note="N-LINKED (GLCNAC...) (POTENTIAL)." Region 743..768 /gene="PTPRG" /region_name="Transmembrane region" /vntifkey="210" /label=PTPRG /note="POTENTIAL." Region 769..1422 /gene="PTPRG" /region_name="Domain" /vntifkey="1004" /label=PTPRG /note="CYTOPLASMIC (POTENTIAL)." Region 846..1102 /gene="PTPRG" /region_name="Domain" /vntifkey="1000" /label=PTPRG /note="PROTEIN-TYROSINE PHOSPHATASE 1." Site 0..0 /gene="PTPRG" /site_type="active" /vntifkey="220" /label=PTPRG /note="BY SIMILARITY." Region 1103..1422 /gene="PTPRG" /region_name="Domain" /vntifkey="1000" /label=PTPRG /note="PROTEIN-TYROSINE PHOSPHATASE 2." Site 0..0 /gene="PTPRG" /site_type="unclassified" /vntifkey="265" /label=PTPRG /note="ANCESTRAL ACTIVE SITE." ORIGIN 1 mrrllqpcww ifflkitssv lhdvvcfpal tegyvgslhe srhgssvqir rrkasgdpyw 61 gysgtygpeh wvtssekcgg shqspidivd hqahvlyeyq elqldgfdne ssnktwmknt 121 gktvaillkd dyfvsgaglp grfkaekvef hwgqsngsag sehsingkrf pvemqiyfyn 181 pddfdsfgta vlenrevgam avffqvsqrd nsaldpiirg lkgvvhheke tfldpfvlrd 241 llptslgsyy rytgslttpp cseivewiif rkpvpisyhq leafysiftt eqqdhvksve 301 ylrnnfrpqq rlnnrkvsks avkdawsqdm tdilenplgt easkacstpp vnmkvqpvnr 361 tallvtwnqp etiyhppimn ymisyswtkn edekektftk dsdkdlkaii shvspdilyl 421 frvqavcrne mrsdfsqtml fqanttrife gtrivktgvp taspassadm apissgsstw 481 tssglpfsfv smatgmgpss sgsqatvasv vtstllaglg fsgssissfp ssvwptrlpt 541 aaaptkqagr pvvattepaa aspgperdsa ltkdgegaee gekdeksese dgereheeed 601 ekeaekkeks rataaaearn stepsvatas pnwtaeeegn ktvsgeepnq nvvpkagrpe 661 eesftdadtq pqplpstqvp paftdelyle kiprrpettr kplpkdnrfl eeypsdnkfi 721 tinpadknss smatrpspgk mewiiplivv saltfvclil liavlvywrk cfqtahfyve 781 dsssprvvpn esipiipipd dmeaipvkqf vkhiselysn nqhgfsedfe evqrctadmn 841 itaehsnhpd nkhknryini laydhsrvkl rplpgkdskh sdyinanyvs gynkakayia 901 tqgplkstfe dfwrmiwaqh tgiivmitnl vekgrrkcdq ywptenseey gniivtlkst 961 nihacytvrp lhgqehkdek gserkpkgrq nertviqyhy tqwpdmgvpe yalpvltfvr 1021 rssaartphm gpvvvhcsag vgrtgtyivi dsmlqqikdk stvnvlgflk hirtqrnylv 1081 qteeqyifih dalleailgk etevsanqlh syvnsilipg iggktrlekq fklvtqcnak 1141 yvecfsaqkd cnkeknrnss vvpserarvg laplpgmkgt dyinasyimg yyrsnenvit 1201 qhplphttkd fwrmiwdhna qiivmlpdnq slaedefvyw psreesmnce aftvtliskd 1261 rlclsneeqi iihdfileat qddyvlevrh fqcpkwpnpd apisstfeli nvikeealtr 1321 dgptivhdey gavsagtlca lttlsqqlen enavdvfqva kminlmrpgv ftdieqyqfl 1381 ykamlslvst kengngpmtl dkngavmasd esdpaesmes lv // LOCUS cPTPsigma\ 1499 aa 17-MAY-2003 DEFINITION protein-tyrosine-phosphatase (EC 3.1.3.48) - chicken. ACCESSION I50212 DBSOURCE pir: locus I50212; summary: #length 1499 #molecular-weight 168570 #checksum 8393 ; genetic: #gene CRYPalpha1 ; superfamily: leukocyte antigen-related protein; fibronectin type III repeat homology; immunoglobulin homology; leukocyte common antigen cytosolic domain homology; protein-tyrosine-phosphatase homology ; PIR dates: 13-Sep-1996 #sequence_revision 13-Sep-1996 #text_change 21-Jan-2000 . KEYWORDS phosphoprotein; phosphoric monoester hydrolase; tyrosine-specific phosphatase. SOURCE Gallus gallus (chicken). ORGANISM Gallus gallus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. REFERENCE 1 (residues 1 to 1499) AUTHORS Stoker,A.W. TITLE Isoforms of a novel cell adhesion molecule-like protein tyrosine phosphatase are implicated in neural development JOURNAL Mech. Dev. 46 (3), 201-217 (1994) MEDLINE 95001563 COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|301941142| COMMENT VNTNAME|cPTPsigma (I50212)| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..1499 /organism="Gallus gallus" /db_xref="taxon:9031" /vntifkey="269" Protein 1..1499 /product="protein-tyrosine-phosphatase" /EC_number="3.1.3.48" /vntifkey="270" Region 148..208 /region_name="domain" /vntifkey="1000" /label=IMM1 /note="immunoglobulin homology #label IMM1" Region 245..299 /region_name="domain" /vntifkey="1000" /label=IMM2 /note="immunoglobulin homology #label IMM2" Region 317..399 /region_name="domain" /vntifkey="1018" /label=3FR /note="fibronectin type III repeat homology #label 3FR" Region 881..1499 /region_name="domain" /vntifkey="1000" /label=LAC /note="leukocyte common antigen cytosolic domain homology #label LAC" Site 0..0 /site_type="active" /vntifkey="220" /label=Active_Site_1 /note="Cys (phosphocysteine intermediate)" Site 0..0 /site_type="binding" /vntifkey="1007" /label=Binding_1 /note="substrate phosphate (Arg)" Region 1257..1479 /region_name="domain" /vntifkey="1000" /label=PTP2 /note="protein-tyrosine-phosphatase homology #label PTP2" Site 0..0 /site_type="active" /vntifkey="220" /label=Active_Site_2 /note="Cys (phosphocysteine intermediate)" Site 0..0 /site_type="binding" /vntifkey="1007" /label=Binding_2 /note="substrate phosphate (Arg)" ORIGIN 1 mrilpspgmp allslvslls vllmgcvaes ppvfikkpvd qigvsggvas fvcqatgdpk 61 prvtwnkkgk kvnsqrfeti efdesagavl riqplrtprd eniyecvaqn phgevtvhak 121 ltvlredqlp pgfpnidmgp qlkvvertrt atmlcaasgn pdpeitwfkd flpvdpstsn 181 grikqlrsgg lqiesseetd qgkyecvasn sagvrysspa nlyvrvrrva prfsilpvsh 241 eimpggnvni tcvavgspmp yvkwmqgaed ltpeddmpvg rnvleltdvk dsanytcvam 301 sslgvieava qitvkslpka pgtpvvtett atsititwds gnpdpvsyyv ieyksksqdg 361 pyqikeditt trysigglsp nseyeiwvsa vnsigqgpps esvvtrtgeq apasaprnvq 421 grmlssttmi iqweepvepn gqirgyrvyy tmepdqpvsn wqkhnvddsl lttvgslled 481 etytvrvlaf tsvgdgplsd piqvktqqgv pgqpmnfrae aktetsivls wspprqeiiv 541 kyellfkegd hgrevprnfe pttsftvegl kpnteyvfrl aarsalglga ftpevrertl 601 qsilpknfkv kmvtktsvll swefpenyns ptpykiqyng lnvdvdgrtt kklitnlkph 661 tfynfvlmnr gnsmgglqqn vaawtaanml srkpevthkp dadgnvvvil pdvkssvavq 721 ayyivvvplr ksrggqflnp lgspeemdle eliqdiarlr rrslrhsrql dfpkpyiaar 781 frslpnhfvl gdmkhydnfe nralepgqry vifilavlqe peatfaaspf sdpiqldnpd 841 pqpiidgeeg liwvigpvla vvfiicivia illyknkpds krkdseprtk cllnnaeitp 901 hhpkdpvemr rinfqtpgml shppipvsel aehtehlkan dnlklsqeye sidpgqqftw 961 ehsnlevnkp knryanviay dhsrvillpi egivgsdyin anyidgyrkq nayiatqgpl 1021 petfgdfwrm vweqrsativ mmtkleeksr ikcdqywpgr gtdtygmiqv tlldtielat 1081 fcvrtfslhk ngssekrevr qfqftawpdh gvpeyptpfl aflrrvktcn ppdagpivvh 1141 csagvgrtgc fividamler ikhektvdiy ghvtlmrsqr nymvqtedqy sfihdallea 1201 vacgntevpa rnlytyiqkl aqievgehvt gmelefkrla nskahtsrfi sanlpcnkfk 1261 nrlvnimpye ttrvclqpir gvegsdyina sfidgyrqqk ayiatqgpla ettedfwrml 1321 wennstivvm ltklremgre kchqywpaer saryqyfvvd pmaeynmpqy ilrefkvtda 1381 rdgqsrtvrq fqftdwpeqg vpksgegfid figqvhktke qfgqdgpisv hcsagvgrtg 1441 vfitlsivle rmryegvvdi fqtvkmlrtq pamvqtedey qfcyqaaley lgsfdhyat // LOCUS cPTPzeta\( 832 aa 17-MAY-2003 DEFINITION phosphotyrosyl phosphatase. ACCESSION AAA49015 DBSOURCE locus CHKPHOPHOS accession L27625.1 SOURCE Gallus gallus (chicken). ORGANISM Gallus gallus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. REFERENCE 1 (residues 1 to 832) AUTHORS Rowley,R.B., Lee,J.M., Corbeil,H.B., Charbonneau,R., Jue,K., Dankort,D.L. and Branton,P.E. TITLE Isolation of chicken phosphotyrosyl phosphatase cDNA sequences and identification of a brain-specific species related to human PTP zeta JOURNAL Cell. Mol. Biol. Res. 39 (3), 209-219 (1993) MEDLINE 94122757 COMMENT Method: conceptual translation. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|0| COMMENT VNTNAME|cPTPzeta (AAA49015)| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..832 /organism="Gallus gallus" /sub_species="domesticus" /db_xref="taxon:9031" /tissue_type="embryo" /dev_stage="10 day" /tissue_lib="Clontech CL1001b" /vntifkey="269" Protein 1..832 /product="phosphotyrosyl phosphatase" /vntifkey="270" ORIGIN 1 mqdvlyqgsv thvsegaapp ssdkppkhts stdgnlwfrn ateltsqpvg tmdsshlsqt 61 sytedyvegl kpatvpysgs pvvsqdtsdv dlelphystf afssaelpph slssssgeyg 121 sasaasevls qttqpiynea snsshesrig laeslesekk tviplvvvsa ltficlvilv 181 giliywrkcf qtahfyledn tsprvisapp apvfpvsddv gaipikhfpk hvadlhasng 241 fseefeeiqs ctvdlgitsd ssnhpdnknk nryinivayd htrvklaqla ekdgkltdyi 301 nanyvdgynk pkayiaaqgp lkstaedfwr miwehnvevi vmitnllekg rrkcdqywpa 361 egseeygnfl vtqksvhvla yytvrnftlr ntkikkgsqk grssgrvvtq yhytqwpdmg 421 vpeytlpvlt fvrkashakr havgpivvhc sagvgrtgty vvldsmlqqi qhegtvnifg 481 flkhirtqrn ylvqteeqyi fihdalveai lsketevlet hihayvnall ipgptgktrl 541 ekqfkllsqs ntqqcdysta lkqcnreknr tssiipvers rvgisslsge gtdyinasyi 601 mgyyqsnefi itqhpllhti kdfwrmiwdh naqlivmlpd sqnmaedefv ywpnkdepin 661 cetfkvtmia eehkclskee kliiqdfile atqddyvlev rhfqcpkwpn pdspisktfe 721 lisiikeets nrdgpmivhd ehggvtagtf calttlmhql enensvdvyq vakminlmrp 781 gvftdieqyq flykailslv strqeenpsa smdsngsalp dgnaaesles lv // LOCUS cSHP2\(JC5 593 aa 17-MAY-2003 DEFINITION protein-tyrosine-phosphatase (EC 3.1.3.48), nonreceptor type 11 - chicken. ACCESSION JC5167 DBSOURCE pir: locus JC5167; summary: #length 593 #molecular-weight 67982 #checksum 3712 ; superfamily: protein-tyrosine-phosphatase, nonreceptor type 6; protein-tyrosine-phosphatase homology; SH2 homology ; PIR dates: 21-Feb-1997 #sequence_revision 27-Feb-1997 #text_change 16-Jul-1999 . KEYWORDS phosphoprotein; phosphoric monoester hydrolase; tyrosine-specific phosphatase. SOURCE Gallus gallus (chicken). ORGANISM Gallus gallus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. REFERENCE 1 (residues 1 to 593) AUTHORS Park,C.Y., LaMontagne,K.R., Tonks,N.K. and Hayman,M.J. TITLE Cloning and expression of the chicken protein tyrosine phosphatase SH-PTP2 JOURNAL Gene 177 (1-2), 93-97 (1996) MEDLINE 97080506 REMARK erythroblast COMMENT This enzyme plays positive roles in mitogenic signaling and early development. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|301941188| COMMENT VNTNAME|cSHP2 (JC5167)| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..593 /organism="Gallus gallus" /db_xref="taxon:9031" /vntifkey="269" Protein 1..593 /product="protein-tyrosine-phosphatase, nonreceptor type 11" /EC_number="3.1.3.48" /vntifkey="270" /note="phosphotyrosine phosphatase; PTP1D; PTP2c; SH-PTP2; SyP" Region 6..105 /region_name="domain" /vntifkey="1026" /label=SH2_1 /note="SH2" Region 6..100 /region_name="domain" /vntifkey="1026" /label=SH2A /note="SH2 homology #label SH2A" Region 112..214 /region_name="domain" /vntifkey="1026" /label=SH2B /note="SH2 homology #label SH2B" Region 112..193 /region_name="domain" /vntifkey="1026" /label=SH2_4 /note="SH2" Region 273..510 /region_name="domain" /vntifkey="1000" /label=PTP /note="protein-tyrosine-phosphatase homology #label PTP" Site 0..0 /site_type="active" /vntifkey="220" /label=Active_Site_1 /note="Cys (phosphocysteine intermediate)" Site 0..0 /site_type="binding" /vntifkey="1007" /label=Binding_1 /note="substrate phosphate (Arg)" Site 0..0 /site_type="binding" /vntifkey="1007" /label=Binding_2 /note="phosphate (Tyr) (covalent)" Site 0..0 /site_type="binding" /vntifkey="1007" /label=Binding_3 /note="phosphate (Tyr) (covalent)" Region 559..570 /region_name="region" /vntifkey="266" /label=Region_1 /note="proline-rich" Site 0..0 /site_type="binding" /vntifkey="1007" /label=Binding_4 /note="phosphate (Tyr) (covalent)" ORIGIN 1 mtsrrwfhpn itgveaenll ltrgvdgsfl arpsksnpgd ftlsvrrtga vthikiqntg 61 dyydlyggek fatlaelvqy ymehhgqlke kngdvielky plncadptse rwfhghlsgr 121 eaeklltekg khgsflvres qshpgdfvls vrtgddkges ndgkskvthv mihcqdlkyd 181 vgggekfdsl tdlvehykkn pmvetlgtvl qlkqplnttr inaaeiesrv relsklaett 241 dkvkqgfwee fetlqqqeck llysrkegqr qenknknryk nilpfdhtrv vlhdgdpnep 301 vsdyinanii mpefetkcnn skpkksyiat qgclqntvnd fwrmvfqens rvivmttkev 361 ergkskcvky wpdeyslkey gvmrvrnvke saahdytlre lklskvgqgn tertvwqyhf 421 rtwpdhgvps dpggvldfle evhhkqesis dagpvvvhcs agigrtgtfi vidilidiir 481 ekgvdcdidv pktiqmvrsq rsgmvqteaq yrfiymavqh yietlqrrie eeqkskrkgh 541 eytnikysls dqtsgdqspl ppctptptcp emredsarvy envglmqqqk sfr // LOCUS cypcaCD45\ 1216 aa 17-MAY-2003 DEFINITION CD45 [Cyprinus carpio]. ACCESSION BAA92179 DBSOURCE accession AB031424.1 SOURCE Cyprinus carpio (common carp). ORGANISM Cyprinus carpio Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Cyprinus. REFERENCE 1 AUTHORS Fujiki,K., Shin,D.H., Nakao,M. and Yano,T. TITLE Molecular cloning of carp (Cyprinus carpio) leucocyte cell-derived chemotaxin 2, glia maturation factor beta, CD45 and lysozyme C by use of suppression subtractive hybridisation JOURNAL Fish Shellfish Immunol. 10 (7), 643-650 (2000) MEDLINE 20531692 REFERENCE 2 (residues 1 to 1216) AUTHORS Fujiki,K., Nakao,M., Shin,D. and Yano,T. TITLE Direct Submission JOURNAL Submitted (24-AUG-1999) Kazuhiro Fujiki, Kyushu University, Laboratory of Marine Biochemistry, Faculty of Agriculture; Hakozaki 6-10-1, Higashi-ku, Fukuoka, Fukuoka 812-8581, Japan (E-mail:fujikik@agr.kyushu-u.ac.jp, Tel:81-92-642-2896, Fax:81-92-642-2894) COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|301944007| COMMENT VNTNAME|cypcaCD45 (BAA92179)| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..1216 /organism="Cyprinus carpio" /db_xref="taxon:7962" /cell_type="leukocytes" /vntifkey="269" Protein 1..1216 /product="CD45" /vntifkey="270" ORIGIN 1 marffalgpl vlvlclvlfl sptstseqdt dtkvtgssns ptimqsatpt palptgsvkg 61 vkandsgtte vpcqyrlivn gyeknsllvn ingsksqnyt irikdkksek kipvsivsdt 121 ttidilfewl kpctnysvni dncnvvgenh fnlnvlksvn hsaepkgdeq vcfkdskwnl 181 tkcvnitted scvqkpiqin letcnytmnv hmppvkpeit fsesiptkfv wsnkplssdn 241 vtsqckdtfk vkctddteyd ldkdvflkps eeytctgkyk yyntsidsks kqvnihcewi 301 netvfsevts nsivifwnls pgdkckgitw ekfsaickks hdqkcrkvnd ttaecvfsel 361 ksyinytctl saevnksigv fpiytrdfnq rtnssnpsfe dhdnvkvket shnsfnvnck 421 nlkpdewngp kgiyiaklls nrppvtkenp kscsftfenl yyhteytiei iaingnknes 481 sakathstry ndkaligflv flilvtslal lfvlyklfll krkrtaedee illtqplrrv 541 epiyagglve ayknkiadeg rlfmdefqsi prifsnytik eakksenqyk nryvdilpyd 601 ynrvtlstgg ednyinasfi egyrepkkyi aaqgpkdetv vdfwrmvweq kssiivmvtr 661 ceegnktkca qywpsldrea eifeefvvki rseehcpdyv irhlilnnkr ekgserevth 721 iqfiswpdhg vpgdpslllk lrrrvnsfkn ffsgpvvvhc sagvgrtgty msidamiesl 781 eaegrvdiyg fvaklrrqrc lmvqveaqyi lihtalieyn qfgetevsls efhsvlntlr 841 qkngsdpsll ekefqklpkf kkwrtmntgs sednkkknrd savipydfnr vifrldiegn 901 qtsdpedeee yssdeeeesn qyinasfidg ywcnksliaa qgplqstaee fllmlyqqqt 961 ktlvmltdcq edgkdycfqy wgdekktygd meievkktet fptyvrrhle iqslkkkevl 1021 kvdqyqflkw rgrelpenaq elvemasiir enghydnskt nrnvpivvhc nngssrtgif 1081 calwnlldsa yteklvdvlq evknlrklrq gmvetieqyq flytalegaf pvqngavktp 1141 pakdaaqvin ettalltepn stsgadqkea eestaaesne qgakesstae apaaegdgek 1201 atsegptngp tatvev // LOCUS fuCD45\(CA 1246 aa 17-MAY-2003 DEFINITION CD45 [Takifugu rubripes]. ACCESSION CAB96211 DBSOURCE embl locus FRU243429, accession AJ243429.1 SOURCE Takifugu rubripes. ORGANISM Takifugu rubripes Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; Acanthomorpha; Acanthopterygii; Percomorpha; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu. REFERENCE 1 AUTHORS Diaz del Pozo,E.M., Beverley,P.C. and Timon,M. TITLE Genomic structure and sequence of the leukocyte common antigen (CD45) from the pufferfish Fugu rubripes and comparison with its mammalian homologue JOURNAL Unpublished REFERENCE 2 (residues 1 to 1246) AUTHORS Diaz del Pozo,E.M. TITLE Direct Submission JOURNAL Submitted (25-JUN-1999) Diaz del Pozo E.M., CD45 Group, The Edward Jenner Institute for Vaccine Research, High Street, Compton, Newbury, Berkshire, RG20 7NN, UNITED KINGDOM COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|301950228| COMMENT VNTNAME|fuCD45 (CAB96211)| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..1246 /organism="Takifugu rubripes" /db_xref="taxon:31033" /clone="ptp-16" /tissue_type="spleen" /vntifkey="269" Protein 1..1246 /product="CD45" /EC_number="3.1.3.48" /function="protein tyrosine phosphatase" /vntifkey="270" Region 1..19 /vntifkey="200" /label=Signal_1 Region 20..1246 /product="CD45" /EC_number="3.1.3.48" /vntifkey="203" /label=Chain_1 ORIGIN 1 magyfglnil lwagivtlas ssttspaltt hastvteanv tllvapltst hnsssnlstn 61 lslssttpaa asettvsltt pttpmaltni saitsstnat sdaptqppaa pqcsytlkpi 121 pfgfrltisn fttaglynlt lqeqddmtet tyspdktsld ildlkpctsy rhwlsltlqh 181 saidcnqtvn ttatlqpkme dfqnvksspg sicyqskwni rslltqpnnm qlrdddtfci 241 rydskdictn ftknvstscg sfpftkfidl vpshitmrrl gvypekiett fppncknwtv 301 ehvcsekgsp hqnksltele pytdyscaav vtrgtvsmwt edidirincn lliyecsksn 361 vltntsmnlh wnltssvckd lftrfnfsyn cycdnpvkgs kdvplksqqv scsfsaldaf 421 edytcginvk ykkfsvldrv flyrtepgip erppqlhldv hehnqitvkv dkisrfngps 481 kfyivrlyeg kthketrngt kpsfvfkdls ysteytvqas tfnghfessp htrttstfyn 541 epalinflif liivtsvali lvaykiyvlk rkrsrdtses milipktnde eklifveplt 601 setlldaykr kiadegrlfl aefqsiprif skytvkeakk shnvpknryv dilpydynrv 661 qlttgngsag cdyinasfid gfkelkkyia aqgpkeetvs nfwrmiweqq tsiivmvsrc 721 eegnrikcaq ywpsedrdte ifeefivklt sedhypdyii rhlsltnkkd kgserevthi 781 qfmswpdhgv peeaqlllkl rrrvnsfknf fsgpivvhcs agvgrtgtyi gidammesle 841 aegrvdiygy vvmlrrqrcl mvqveaqyil ihqallehtq fgetentlqe lhstlntlkq 901 rssdneptll edeferlpnf knwrtfntgv teenkkknrt ssvipydynr vllkldeeks 961 hesdpdpddd ydtssyddie dsakyinasl lsgywgphtf isaqtplpdt vadfwsmilq 1021 krvsivvmls dcsqgdedcv ywgedkktve dievetestd nspnfilrnm mihhlktdah 1081 qqvkhfqflk wgdkevpekp qdladlikei khrcgytwpr stpiivhcnd gssrsgafca 1141 lwnlldnaek ekmvdvfqvv ktlrkerqgm cpsleqyqfl ydalevvypv qngdvkaaqn 1201 svqivnetae qqasttrtdh qeaeegadgd vstatgekss tvtvev // LOCUS hBDP1\(NP_ 460 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, non-receptor type 18; brain-derived phosphatase [Homo sapiens]. ACCESSION NP_055184 DBSOURCE REFSEQ: accession NM_014369.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 460) AUTHORS Kim,Y.W., Wang,H., Sures,I., Lammers,R., Martell,K.J. and Ullrich,A. TITLE Characterization of the PEST family protein tyrosine phosphatase BDP1 JOURNAL Oncogene 13 (10), 2275-2279 (1996) MEDLINE 97108674 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X79568.1 and BI261717.1. On Jan 25, 2002 this sequence version replaced gi:7657484. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This gene was found to be expressed in brain, colon tissues, and several different tumor-derived cell lines. The bilogical function of this PTP has not yet been determined. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|304502400| COMMENT VNTNAME|hBDP1 (NP_055184) PTPN18| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..460 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="2" /map="2q21.2" /vntifkey="269" Protein 1..460 /product="protein tyrosine phosphatase, non-receptor type 18" /EC_number="3.1.3.48" /vntifkey="270" /note="brain-derived phosphatase" Region 26..292 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 msrsldsars flerleargg regavlagef sdiqacsaaw kadgvcstva gsrpenvrkn 61 rykdvlpydq trvilsllqe eghsdyingn firgvdgsla yiatqgplph tlldfwrlvw 121 efgvkvilma creiengrkr cerywaqeqe plqtglfcit likekwlned imlrtlkvtf 181 qkesrsvyql qymswpdrgv psspdhmlam veearrlqgs gpeplcvhcs agcgrtgvlc 241 tvdyvrqlll tqmippdfsl fdvvlkmrkq rpaavqteeq yrflyhtvaq mfcstlqnas 301 phyqnikenc aplyddalfl rtpqallaip rppggvlrsi svpgspgham adtyavvqkr 361 gapagagsgt qtgtgtgtga rsaeeaplys kvtpraqrpg ahaedargtl pgrvpadqsp 421 agsgayedva ggaqtgglgf nlrigrpkgp rdppaewtrv // LOCUS hCD45\(NP_ 1304 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, C isoform 1 precursor; protein tyrosine phosphatase, receptor type, c polypeptide; leukocyte-common antigen; T200 glycoprotein; human homolog of severe combined immunodeficiency due to PTPRC deficiency; SCID due to PTPRC deficiency; CD45 antigen [Homo sapiens]. ACCESSION NP_002829 DBSOURCE REFSEQ: accession NM_002838.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 1304) AUTHORS Baldwin,T.A. and Ostergaard,H.L. TITLE The protein-tyrosine phosphatase CD45 reaches the cell surface via golgi-dependent and -independent pathways JOURNAL J. Biol. Chem. 277 (52), 50333-50340 (2002) MEDLINE 22384317 REMARK GeneRIF: reaches the cell surface via Golgi-dependent and -independent pathways REFERENCE 2 (residues 1 to 1304) AUTHORS Harashima,A., Suzuki,M., Okochi,A., Yamamoto,M., Matsuo,Y., Motoda,R., Yoshioka,T. and Orita,K. TITLE CD45 tyrosine phosphatase inhibits erythroid differentiation of umbilical cord blood CD34+ cells associated with selective inactivation of Lyn JOURNAL Blood 100 (13), 4440-4445 (2002) MEDLINE 22340750 REMARK GeneRIF: CD45 may play a pivotal role in erythropoiesis. CD45 tyrosine phosphatase inhibits erythroid differentiation of umbilical cord blood CD34+ cells associated with selective inactivation of Lyn. REFERENCE 3 (residues 1 to 1304) AUTHORS Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J. TITLE Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases JOURNAL J. Biol. Chem. 277 (49), 47263-47269 (2002) MEDLINE 22344739 REMARK GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are a common but specific mechanism that is likely to be regulated- domain2s and the wedge structures are crucial determinants of binding specificity, thus regulating cross-talk between RPTPs REFERENCE 4 (residues 1 to 1304) AUTHORS Pradhan,D. and Morrow,J. TITLE The spectrin-ankyrin skeleton controls CD45 surface display and interleukin-2 production JOURNAL Immunity 17 (3), 303-315 (2002) MEDLINE 22241694 REMARK GeneRIF: The spectrin-ankyrin skeleton controls CD45 surface display and interleukin-2 production. REFERENCE 5 (residues 1 to 1304) AUTHORS Ballerini,C., Rosati,E., Salvetti,M., Ristori,G., Cannoni,S., Biagioli,T., Massacesi,L., Sorbi,S. and Vergelli,M. TITLE Protein tyrosine phosphatase receptor-type C exon 4 gene mutation distribution in an Italian multiple sclerosis population JOURNAL Neurosci. Lett. 328 (3), 325-327 (2002) MEDLINE 22142931 REMARK GeneRIF: Role of the C-->G mutation in position 77 of exon 4 of the protein tyrosine phosphatase receptor-type C (PTPRC) gene, coding for the CD45 molecule, for the development of multiple sclerosis (MS) in Italy. REFERENCE 6 (residues 1 to 1304) AUTHORS Yamada,T., Zhu,D., Saxon,A. and Zhang,K. TITLE CD45 controls interleukin-4-mediated IgE class switch recombination in human B cells through its function as a Janus kinase phosphatase JOURNAL J. Biol. Chem. 277 (32), 28830-28835 (2002) MEDLINE 22151051 REMARK GeneRIF: CD45 controls interleukin-4-mediated IgE class switch recombination in human B cells REFERENCE 7 (residues 1 to 1304) AUTHORS Yu,C., Yu,H.S., Sun,K.H., Hsieh,S.C. and Tsai,C.Y. TITLE Anti-CD45 isoform antibodies enhance phagocytosis and gene expression of IL-8 and TNF-alpha in human neutrophils by differential suppression on protein tyrosine phosphorylation and p56lck tyrosine kinase JOURNAL Clin. Exp. Immunol. 129 (1), 78-85 (2002) MEDLINE 22095000 REMARK GeneRIF: Biological functions of membrane expressed CD45 isoforms on PMNs were studied. Cross-linking of CD45 isoforms by specific MAbs stimulated different PMN activities by differential suppression on protein tyrosine phosphorylation and p56lck. REFERENCE 8 (residues 1 to 1304) AUTHORS Jacobsen,M., Hoffmann,S., Cepok,S., Stei,S., Ziegler,A., Sommer,N. and Hemmer,B. TITLE A novel mutation in PTPRC interferes with splicing and alters the structure of the human CD45 molecule JOURNAL Immunogenetics 54 (3), 158-163 (2002) MEDLINE 22067726 REMARK GeneRIF: a mutation in PTPRC interferes with splicing and alters the structure of the CD45 molecule REFERENCE 9 (residues 1 to 1304) AUTHORS Tchilian,E.Z. and Beverley,P.C. TITLE CD45 in memory and disease JOURNAL Arch. Immunol. Ther. Exp. (Warsz.) 50 (2), 85-93 (2002) MEDLINE 22017393 REMARK GeneRIF: Role of high and low molecular weight isoforms of CD45 in the function of na##ve and memory T lymphocytes. Review. REFERENCE 10 (residues 1 to 1304) AUTHORS Fajka-Boja,R., Szemes,M., Ion,G., Legradi,A., Caron,M. and Monostori,E. TITLE Receptor tyrosine phosphatase, CD45 binds galectin-1 but does not mediate its apoptotic signal in T cell lines JOURNAL Immunol. Lett. 82 (1-2), 149-154 (2002) MEDLINE 22003829 REMARK GeneRIF: Receptor tyrosine phosphatase, CD45 binds galectin-1 but does not mediate its apoptotic signal in Jurkat cells REFERENCE 11 (residues 1 to 1304) AUTHORS Fukuhara,K., Okumura,M., Shiono,H., Inoue,M., Kadota,Y., Miyoshi,S. and Matsuda,H. TITLE A study on CD45 isoform expression during T-cell development and selection events in the human thymus JOURNAL Hum. Immunol. 63 (5), 394-404 (2002) MEDLINE 21972715 REMARK GeneRIF: analysis of CD45 isoform expression during T-cell development and selection in the human thymus REFERENCE 12 (residues 1 to 1304) AUTHORS Wu,L., Fu,J. and Shen,S.H. TITLE SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription JOURNAL Mol. Cell. Biol. 22 (8), 2673-2686 (2002) MEDLINE 21907230 REMARK GeneRIF: SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription. REFERENCE 13 (residues 1 to 1304) AUTHORS Ishikawa,H., Tsuyama,N., Abroun,S., Liu,S., Li,F.J., Taniguchi,O. and Kawano,M.M. TITLE Requirements of src family kinase activity associated with CD45 for myeloma cell proliferation by interleukin-6 JOURNAL Blood 99 (6), 2172-2178 (2002) MEDLINE 21866149 REMARK GeneRIF: Requirements of src family kinase activity associated with CD45 for myeloma cell proliferation by interleukin-6 REFERENCE 14 (residues 1 to 1304) AUTHORS Tchilian,E.Z., Dawes,R., Ramaley,P.A., Whitworth,J.A., Yuldasheva,N., Wells,R.S., Watera,C., French,N., Gilks,C.F., Kunachiwa,W., Ruzibakiev,R., Leetrakool,N., Carrington,C.V., Ramdath,D.D., Gotch,F., Stephens,H.A., Hill,A.V. and Beverley,P.C. TITLE A CD45 polymorphism associated with abnormal splicing is absent in African populations JOURNAL Immunogenetics 53 (10-11), 980-983 (2002) MEDLINE 21850514 REMARK GeneRIF: we examined the frequency of the C77G allele in African and Asian populations from countries with high or low prevalence of HIV infection; Here we report that the variant CD45 C77G allele is absent in African populations REFERENCE 15 (residues 1 to 1304) AUTHORS Wood,J.P., Bieda,K., Segni,M., Herwig,J., Krause,M., Usadel,K.H. and Badenhoop,K. TITLE CD45 exon 4 point mutation does not confer susceptibility to type 1 diabetes mellitus or Graves' disease JOURNAL Eur. J. Immunogenet. 29 (1), 73-74 (2002) MEDLINE 21830605 REMARK GeneRIF: CD45 variant (C77G, exon 4) does not confer susceptibility to either IDDM or Graves' disease REFERENCE 16 (residues 1 to 1304) AUTHORS Moro,H., Iwai,K., Mori,N., Watanabe,M., Fukushi,M., Oie,M., Arai,M., Tanaka,Y., Miyawaki,T., Gejyo,F., Arakawa,M. and Fujii,M. TITLE Interleukin-2-dependent but not independent T-cell lines infected with human T-cell leukemia virus type 1 selectively express CD45RO, a marker for persistent infection in vivo JOURNAL Virus Genes 23 (3), 263-271 (2001) MEDLINE 21636965 REMARK GeneRIF: role of CD45RO in the persistent HTLV-1 infection in vivo REFERENCE 17 (residues 1 to 1304) AUTHORS Irie-Sasaki,J., Sasaki,T., Matsumoto,W., Opavsky,A., Cheng,M., Welstead,G., Griffiths,E., Krawczyk,C., Richardson,C.D., Aitken,K., Iscove,N., Koretzky,G., Johnson,P., Liu,P., Rothstein,D.M. and Penninger,J.M. TITLE CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling JOURNAL Nature 409 (6818), 349-354 (2001) MEDLINE 21069057 REFERENCE 18 (residues 1 to 1304) AUTHORS Goff,L.K., van Soest,S., Timon,M., Tchilian,E. and Beverley,P.C. TITLE Protein tyrosine phosphatase receptor type C polypeptide (PTPRC) on human chromosome band 1q31-->q32 localizes with marker D1S413(1) on a 610-kb yeast artificial chromosome JOURNAL Cytogenet. Cell Genet. 87 (3-4), 223-224 (1999) MEDLINE 20169194 REFERENCE 19 (residues 1 to 1304) AUTHORS Petricoin,E.F. III, Ito,S., Williams,B.L., Audet,S., Stancato,L.F., Gamero,A., Clouse,K., Grimley,P., Weiss,A., Beeler,J., Finbloom,D.S., Shores,E.W., Abraham,R. and Larner,A.C. TITLE Antiproliferative action of interferon-alpha requires components of T-cell-receptor signalling JOURNAL Nature 390 (6660), 629-632 (1997) MEDLINE 98065953 REFERENCE 20 (residues 1 to 1304) AUTHORS Kaplan,R., Morse,B., Huebner,K., Croce,C., Howk,R., Ravera,M., Ricca,G., Jaye,M. and Schlessinger,J. TITLE Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (18), 7000-7004 (1990) MEDLINE 90384936 REFERENCE 21 (residues 1 to 1304) AUTHORS Schraven,B., Samstag,Y., Altevogt,P. and Meuer,S.C. TITLE Association of CD2 and CD45 on human T lymphocytes JOURNAL Nature 345 (6270), 71-74 (1990) MEDLINE 90231464 REFERENCE 22 (residues 1 to 1304) AUTHORS Pingel,J.T. and Thomas,M.L. TITLE Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation JOURNAL Cell 58 (6), 1055-1065 (1989) MEDLINE 89376557 REFERENCE 23 (residues 1 to 1304) AUTHORS Charbonneau,H., Tonks,N.K., Walsh,K.A. and Fischer,E.H. TITLE The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase JOURNAL Proc. Natl. Acad. Sci. U.S.A. 85 (19), 7182-7186 (1988) MEDLINE 89017162 REFERENCE 24 (residues 1 to 1304) AUTHORS Streuli,M., Hall,L.R., Saga,Y., Schlossman,S.F. and Saito,H. TITLE Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigens JOURNAL J. Exp. Med. 166 (5), 1548-1566 (1987) MEDLINE 88061067 REFERENCE 25 (residues 1 to 1304) AUTHORS Ralph,S.J., Thomas,M.L., Morton,C.C. and Trowbridge,I.S. TITLE Structural variants of human T200 glycoprotein (leukocyte-common antigen) JOURNAL EMBO J. 6 (5), 1251-1257 (1987) MEDLINE 87275816 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Y00638.1 and Y00062.1. On Feb 8, 2002 this sequence version replaced gi:4506307. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. Transcript Variant: This variant (1) encodes the longest isoform (1). COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|304502400| COMMENT VNTNAME|hCD45 (NP_002829) PTPRC| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..1304 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="1" /map="1q31-q32" /vntifkey="269" Protein 1..1304 /product="protein tyrosine phosphatase, receptor type, C isoform 1 precursor" /EC_number="3.1.3.48" /vntifkey="270" /note="protein tyrosine phosphatase, receptor type, c polypeptide; leukocyte-common antigen; T200 glycoprotein; human homolog of severe combined immunodeficiency due to PTPRC deficiency; SCID due to PTPRC deficiency; CD45 antigen" Region 1..23 /vntifkey="200" /label=Signal_1 Region 21..135 /region_name="COG5243, HRD1, HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]" /db_xref="CDD:COG5243" /vntifkey="266" /label=Region_1 /note="HRD1" Region 24..1304 /product="protein tyrosine phosphatase, receptor type, C" /vntifkey="203" /label=Chain_1 Region 390..460 /region_name="Fibronectin type 3 domain" /db_xref="CDD:smart00060" /vntifkey="1000" /label=Dom_Misc_1 /note="FN3" Region 486..563 /region_name="Fibronectin type III domain" /db_xref="CDD:pfam00041" /vntifkey="1000" /label=Dom_Misc_2 /note="fn3" Region 650..910 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_2 /note="PTPc" Region 942..1227 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_3 /note="PTPc" ORIGIN 1 mylwlkllaf gfafldtevf vtgqsptpsp tglttakmps vplssdplpt httafspast 61 ferendfset ttslspdnts tqvspdsldn asafnttgvs svqtphlpth adsqtpsagt 121 dtqtfsgsaa naklnptpgs naisdvpger stastfptdp vspltttlsl ahhssaalpa 181 rtsnttitan tsdaylnase tttlspsgsa vistttiatt pskptcdeky anitvdylyn 241 ketklftakl nvnenvecgn ntctnnevhn ltecknasvs ishnsctapd ktlildvppg 301 vekfqlhdct qvekadttic lkwknietft cdtqnityrf qcgnmifdnk eiklenlepe 361 heykcdseil ynnhkftnas kiiktdfgsp gepqiifcrs eaahqgvitw nppqrsfhnf 421 tlcyiketek dclnldknli kydlqnlkpy tkyvlslhay iiakvqrngs aamchfttks 481 appsqvwnmt vsmtsdnsmh vkcrpprdrn gpheryhlev eagntlvrne shkncdfrvk 541 dlqystdytf kayfhngdyp gepfilhhst synskaliaf lafliivtsi allvvlykiy 601 dlhkkrscnl deqqelverd dekqlmnvep ihadillety krkiadegrl flaefqsipr 661 vfskfpikea rkpfnqnknr yvdilpydyn rvelseingd agsnyinasy idgfkeprky 721 iaaqgprdet vddfwrmiwe qkatvivmvt rceegnrnkc aeywpsmeeg trafgdvvvk 781 inqhkrcpdy iiqklnivnk kekatgrevt hiqftswpdh gvpedphlll klrrrvnafs 841 nffsgpivvh csagvgrtgt yigidamleg leaenkvdvy gyvvklrrqr clmvqveaqy 901 ilihqalvey nqfgetevnl selhpylhnm kkrdppseps pleaefqrlp syrswrtqhi 961 gnqeenkskn rnsnvipydy nrvplkhele mskesehdsd essdddsdse epskyinasf 1021 imsywkpevm iaaqgplket igdfwqmifq rkvkvivmlt elkhgdqeic aqywgegkqt 1081 ygdievdlkd tdksstytlr vfelrhskrk dsrtvyqyqy tnwsveqlpa epkelismiq 1141 vvkqklpqkn ssegnkhhks tpllihcrdg sqqtgifcal lnllesaete evvdifqvvk 1201 alrkarpgmv stfeqyqfly dviastypaq ngqvkknnhq edkiefdnev dkvkqdancv 1261 nplgapeklp eakeqaegse ptsgtegpeh svngpaspal nqgs // LOCUS hDEP1\(NP_ 1337 aa 17-MAY-2003 DEFINITION protein tyrosine phosphatase, receptor type, J precursor; protein tyrosine phosphatase, receptor type, J polypeptide; human density enhanced phosphatase-1; CD148 antigen [Homo sapiens]. ACCESSION NP_002834 DBSOURCE REFSEQ: accession NM_002843.2 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 1337) AUTHORS Ruivenkamp,C.A., van Wezel,T., Zanon,C., Stassen,A.P., Vlcek,C., Csikos,T., Klous,A.M., Tripodis,N., Perrakis,A., Boerrigter,L., Groot,P.C., Lindeman,J., Mooi,W.J., Meijjer,G.A., Scholten,G., Dauwerse,H., Paces,V., van Zandwijk,N., van Ommen,G.J. and Demant,P. TITLE Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers JOURNAL Nat. Genet. 31 (3), 295-300 (2002) MEDLINE 22084388 REMARK GeneRIF: This protein is frequently deleted in human breast cancers. REFERENCE 2 (residues 1 to 1337) AUTHORS Baker,J.E., Majeti,R., Tangye,S.G. and Weiss,A. TITLE Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation JOURNAL Mol. Cell. Biol. 21 (7), 2393-2403 (2001) MEDLINE 21160271 REFERENCE 3 (residues 1 to 1337) AUTHORS Kovalenko,M., Denner,K., Sandstrom,J., Persson,C., Gross,S., Jandt,E., Vilella,R., Bohmer,F. and Ostman,A. TITLE Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1 JOURNAL J. Biol. Chem. 275 (21), 16219-16226 (2000) MEDLINE 20283660 REFERENCE 4 (residues 1 to 1337) AUTHORS Gross,S., Knebel,A., Tenev,T., Neininger,A., Gaestel,M., Herrlich,P. and Bohmer,F.D. TITLE Inactivation of protein-tyrosine phosphatases as mechanism of UV-induced signal transduction JOURNAL J. Biol. Chem. 274 (37), 26378-26386 (1999) MEDLINE 99403084 REFERENCE 5 (residues 1 to 1337) AUTHORS Tangye,S.G., Phillips,J.H., Lanier,L.L., de Vries,J.E. and Aversa,G. TITLE CD148: a receptor-type protein tyrosine phosphatase involved in the regulation of human T cell activation JOURNAL J. Immunol. 161 (7), 3249-3255 (1998) MEDLINE 98430639 REFERENCE 6 (residues 1 to 1337) AUTHORS de la Fuente-Garcia,M.A., Nicolas,J.M., Freed,J.H., Palou,E., Thomas,A.P., Vilella,R., Vives,J. and Gaya,A. TITLE CD148 is a membrane protein tyrosine phosphatase present in all hematopoietic lineages and is involved in signal transduction on lymphocytes JOURNAL Blood 91 (8), 2800-2809 (1998) MEDLINE 98200586 REFERENCE 7 (residues 1 to 1337) AUTHORS Honda,H., Inazawa,J., Nishida,J., Yazaki,Y. and Hirai,H. TITLE Molecular cloning, characterization, and chromosomal localization of a novel protein-tyrosine phosphatase, HPTP eta JOURNAL Blood 84 (12), 4186-4194 (1994) MEDLINE 95086212 REFERENCE 8 (residues 1 to 1337) AUTHORS Ostman,A., Yang,Q. and Tonks,N.K. TITLE Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density JOURNAL Proc. Natl. Acad. Sci. U.S.A. 91 (21), 9680-9684 (1994) MEDLINE 95024024 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U10886.1. On Feb 22, 2002 this sequence version replaced gi:4506315. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This PTP is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 (PLCG1) and Linker for Activation of T Cells (LAT). This PTP was also found to dephosphorylate PDGF beta receptor, and may be involved in UV-induced signal transduction. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|304502400| COMMENT VNTNAME|hDEP1 (NP_002834) PTPRJ| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..1337 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="11" /map="11p11.2" /vntifkey="269" Protein 1..1337 /product="protein tyrosine phosphatase, receptor type, J precursor" /EC_number="3.1.3.48" /vntifkey="270" /note="protein tyrosine phosphatase, receptor type, J polypeptide; human density enhanced phosphatase-1; CD148 antigen" Region 1..36 /vntifkey="200" /label=Signal_1 Region 37..1337 /product="protein tyrosine phosphatase, receptor type, J" /vntifkey="203" /label=Chain_1 Region 119..187 /region_name="Fibronectin type 3 domain" /db_xref="CDD:smart00060" /vntifkey="1000" /label=Dom_Misc_1 /note="FN3" Region 369..445 /region_name="Fibronectin type III domain" /db_xref="CDD:pfam00041" /vntifkey="1000" /label=Dom_Misc_2 /note="fn3" Region 540..615 /region_name="Fibronectin type 3 domain" /db_xref="CDD:smart00060" /vntifkey="1000" /label=Dom_Misc_3 /note="FN3" Region 626..705 /region_name="Fibronectin type 3 domain" /db_xref="CDD:smart00060" /vntifkey="1000" /label=Dom_Misc_4 /note="FN3" Region 1040..1300 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_1 /note="PTPc" ORIGIN 1 mkpaarearl pprspglrwa lpllllllrl gqilcaggtp spipdpsvat vatgengitq 61 isstaesfhk qngtgtpqve tntsedgess gandslrtpe qgsngtdgas qktpsstgps 121 pvfdikavsi sptnviltwk sndtaaseyk yvvkhkmene ktitvvhqpw cnitglrpat 181 syvfsitpgi gnetwgdprv ikvitepipv sdlrvaltgv rkaalswsng ngtascrvll 241 esigsheelt qdsrlqvnis glkpgvqyni npyllqsnkt kgdplgtegg ldasntersr 301 agsptapvhd eslvgpvdps sgqqsrdtev llvglepgtr ynatvysqaa ngtegqpqai 361 efrtnaiqvf dvtavnisat sltliwkvsd nesssnytyk ihvagetdss nlnvseprav 421 ipglrsstfy nitvcpvlgd iegtpgflqv htppvpvsdf rvtvvsttei glawsshdae 481 sfqmhitqeg agnsrveitt nqsiiigglf pgtkycfeiv pkgpngtega srtvcnrtvp 541 savfdihvvy vtttemwldw kspdgaseyv yhlvieskhg snhtstydka itlqglipgt 601 lynitispev dhvwgdpnst aqytrpsnvs nidvstntta atlswqnfdd asptysycll 661 iekagnssna tqvvtdigit datvtelipg ssytveifaq vgdgikslep grksfctdpa 721 smasfdcevv pkepalvlkw tcppganagf elevssgawn nathlescss engteyrtev 781 tylnfstsyn isittvscgk maaptrntct tgitdppppd gspnitsvsh nsvkvkfsgf 841 eashgpikay avilttgeag hpsadvlkyt yddfkkgasd tyvtylirte ekgrsqslse 901 vlkyeidvgn esttlgyyng kleplgsyra cvagftnitf hpqnkglidg aesyvsfsry 961 sdavslpqdp gvicgavfgc ifgalvivtv ggfifwrkkr kdaknnevsf sqikpkkskl 1021 irvenfeayf kkqqadsncg faeeyedlkl vgisqpkyaa elaenrgknr ynnvlpydis 1081 rvklsvqths tddyinanym pgyhskkdfi atqgplpntl kdfwrmvwek nvyaiimltk 1141 cveqgrtkce eywpskqaqd ygditvamts eivlpewtir dftvkniqts eshplrqfhf 1201 tswpdhgvpd ttdllinfry lvrdymkqsp pespilvhcs agvgrtgtfi aidrliyqie 1261 nentvdvygi vydlrmhrpl mvqtedqyvf lnqcvldivr sqkdskvdli yqnttamtiy 1321 enlapvttfg ktngyia // LOCUS hGLEPP1\(N 1216 aa 17-MAY-2003 DEFINITION receptor-type protein tyrosine phosphatase O isoform a precursor; glomerular epithelial protein-1; protein tyrosine phosphatase PTP-U2; phosphotyrosine phosphatase U2; PTPase U2; PTPROt [Homo sapiens]. ACCESSION NP_109592 DBSOURCE REFSEQ: accession NM_030667.1 SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 1216) AUTHORS Aguiar,R.C., Yakushijin,Y., Kharbanda,S., Tiwari,S., Freeman,G.J. and Shipp,M.A. TITLE PTPROt: an alternatively spliced and developmentally regulated B-lymphoid phosphatase that promotes G0/G1 arrest JOURNAL Blood 94 (7), 2403-2413 (1999) MEDLINE 99428326 REFERENCE 2 (residues 1 to 1216) AUTHORS Seimiya,H., Sawabe,T., Inazawa,J. and Tsuruo,T. TITLE Cloning, expression and chromosomal localization of a novel gene for protein tyrosine phosphatase (PTP-U2) induced by various differentiation-inducing agents JOURNAL Oncogene 10 (9), 1731-1738 (1995) MEDLINE 95273089 REFERENCE 3 (residues 1 to 1216) AUTHORS Wiggins,R.C., Wiggins,J.E., Goyal,M., Wharram,B.L. and Thomas,P.E. TITLE Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13 JOURNAL Genomics 27 (1), 174-181 (1995) MEDLINE 95394455 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z48541.1 and U20489.1. Summary: This gene encodes a receptor-type protein tyrosine phosphatase containing a single intracellular catalytic domain with a characteristic signature motif. The gene product, which has a transmembrane domain, is an integral membrane protein. Several alternatively spliced transcript variants, some of which encode different isoforms of the protein, have been described. These variants exhibit tissue-specific expression. Transcript Variant: This variant (1) encodes the longest isoform (a) known to date. The encoded protein has a large extracellular domain containing 8 repeats of a fibronectin type III-like motif. This variant is expressed in the glomerulus of kidney and in brain. In kidney, it may play a role in regulating glomerular epithelial cell (podocyte) structure and/or function. COMMENT This file is created by Vector NTI suite COMMENT ORIGDB|GenPept COMMENT VNTDATE|304502400| COMMENT VNTNAME|hGLEPP1 (NP_109592) PTPRO| COMMENT VNTAUTHORNAME|Jannik N Andersen| COMMENT VNTAUTHOREML|jannik@noergaardandersen.com| COMMENT VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| COMMENT VNTOAUTHORNAME|NCBI Entrez| COMMENT VNTOAUTHORTEL|(301)496-2475| COMMENT VNTOAUTHORFAX|(301)480-9241| COMMENT VNTOAUTHOREML|info@ncbi.nlm.nih.gov| COMMENT VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| COMMENT VNTOAUTHORAD1|National Center for Biotechnology Information| COMMENT VNTOAUTHORAD2|National Library of Medicine| COMMENT VNTOAUTHORAD3|Building 38A, Room 8N805| COMMENT VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FEATURES Location/Qualifiers source 1..1216 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="12" /map="12p13.3-p13.2" /vntifkey="269" Protein 1..1216 /product="receptor-type protein tyrosine phosphatase O isoform a precursor" /EC_number="3.1.3.48" /vntifkey="270" /note="glomerular epithelial protein-1; protein tyrosine phosphatase PTP-U2; phosphotyrosine phosphatase U2; PTPase U2; PTPROt" Region 1..29 /vntifkey="200" /label=Signal_1 Region 30..1216 /product="receptor-type protein tyrosine phosphatase O, isoform a" /vntifkey="203" /label=Chain_1 Region 50..813 /region_name="fibronectin type III-like motifs region" /vntifkey="266" /label=Region_1 Region 436..521 /region_name="Fibronectin type III domain" /db_xref="CDD:pfam00041" /vntifkey="1000" /label=Dom_Misc_1 /note="fn3" Region 726..805 /region_name="Fibronectin type III domain" /db_xref="CDD:pfam00041" /vntifkey="1000" /label=Dom_Misc_2 /note="fn3" Region 820..844 /region_name="transmembrane domain" /vntifkey="210" /label=Transmem_1 Region 937..1192 /region_name="Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" /vntifkey="266" /label=Region_2 /note="PTPc" Region 1134..1144 /region_name="catalytic domain signature motif" /vntifkey="1000" /label=Dom_Misc_3 ORIGIN 1 mghlptgihg arrllpllwl fvlfknataf hvtvqddnni vvsleasdvi spasvyvvki 61 tgesknyffe feefnstlpp pvifkasyhg lyyiitlvvv ngnvvtkpsr sitvltkplp 121 vtsvsiydyk pspetgvlfe ihypekynvf trvnisyweg kdfrtmlykd ffkgktvfnh 181 wlpgmcysni tfqlvseatf nkstlveysg vshepkqhrt apyppqnisv rivnlnknnw 241 eeqsgnfpee sfmrsqdtig keklfhftee tpeipsgnis sgwpdfnssd yettsqpyww 301 dsasaapese defvsvlpme yennstlset ekstsgsfsf fpvqmiltwl ppkpptafdg 361 fhihiereen fteylmvdee ahefvaelke pgkyklsvtt fsssgscetr ksqsakslsf 421 yispsgewie eltekpqhvs vhvlssttal mswtssqeny nstivsvvsl tcqkqkesqr 481 lekqyctqvn sskpiienlv pgaqyqvviy lrkgpligpp sdpvtfaivp tgikdlmlyp 541 lgptavvlsw trpylgvfrk yvvemfyfnp atmtsewtty yeiaatvslt asvrianllp 601 awyynfrvtm vtwgdpelsc cdsstisfit apvapeitsv eyfnsllyis wtygddttdl 661 shsrmlhwmv vaegkkkikk svtrnvmtai lslppgdiyn lsvtacterg sntsmlrlvk 721 lepappkslf avnktqtsvt llwveegvad ffev