ID   aotvoCD45_D1\(AAM48511)_Fragm\(5') STANDARD;PRT;   262 AA.
AC   AAM48511;
DT   26-JUN-2003
DE   CD45 phosphatase [Aotus vociferans].
OS   Aotus vociferans.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Platyrrhini; Cebidae; Aotinae; Aotus.
CC   Method: conceptual translation.
CC   GPRFLN|REFERENCE   1  (residues 1 to 433)
CC   GPRFLN|  AUTHORS   Montoya,G.E., Vernot,J.P. and Patarroyo,M.E.
CC   GPRFLN|  TITLE     Partial characterization of the CD45 phosphatase cDNA in the owl
CC   GPRFLN|            monkey Aotus vociferans
CC   GPRFLN|  JOURNAL   Unpublished
CC   GPRFLN|REFERENCE   2  (residues 1 to 433)
CC   GPRFLN|  AUTHORS   Montoya,G.E., Vernot,J.P. and Patarroyo,M.E.
CC   GPRFLN|  TITLE     Direct Submission
CC   GPRFLN|  JOURNAL   Submitted (26-MAR-2001) Fisiologia Molecular, FIDIC, Avenida El
CC   GPRFLN|            Dorado, Carrera 50. INEA, Bogota, DC, Colombia
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302453282|

CC   VNTAUTHORNAME|JNA|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    262       VNTIFKEY:269
FT   PROTEIN       1    262       VNTIFKEY:270
SQ   SEQUENCE   262 AA;
     DILLETYKRK IADEGRLFLA EFQSIPRVFS KFPIKEARKP FNQNKNRYVD ILPYDYNRVE        60
     LSEINGDAGS NYINASYIDG FKEPRKYIAA QGPRDETVDD FWRMIWEQKA TVIVMVTRCE       120
     EGNRNKCAEY WPSVEEGTRA FGDVVVKINQ HKRCPDYIIQ KLNIINKKEK TAGREVTHIQ       180
     FTSWPDHGVP EDPHLLLKLR RRVNAFSNFF XGPIVVHCSA GVGRTGTYIG IDAMLEGLEA       240
     ENKVDVYGYV DKLRRQRCLM VQ                                                262
//
ID   aotvoCD45_D2\(AAM48512)\(3') STANDARD;PRT;   300 AA.
AC   AAM48512;
DT   17-MAY-2003
DE   CD45 phosphatase [Aotus vociferans].
OS   Aotus vociferans.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Platyrrhini; Cebidae; Aotinae; Aotus.
CC   Method: conceptual translation.
CC   GPRFLN|REFERENCE   1  (residues 1 to 365)
CC   GPRFLN|  AUTHORS   Montoya,G.E., Vernot,J.P. and Patarroyo,M.E.
CC   GPRFLN|  TITLE     Partial characterization of the CD45 phosphatase cDNA in the owl
CC   GPRFLN|            monkey Aotus vociferans
CC   GPRFLN|  JOURNAL   Unpublished
CC   GPRFLN|REFERENCE   2  (residues 1 to 365)
CC   GPRFLN|  AUTHORS   Montoya,G.E., Vernot,J.P. and Patarroyo,M.E.
CC   GPRFLN|  TITLE     Direct Submission
CC   GPRFLN|  JOURNAL   Submitted (26-MAR-2001) Fisiologia Molecular, FIDIC, Avenida El
CC   GPRFLN|            Dorado, Carrera 50. INEA, Bogota, DC, Colombia
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302453330|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    300       VNTIFKEY:269
FT   PROTEIN       1    300       VNTIFKEY:270
SQ   SEQUENCE   300 AA;
     NMKKRDPPSE PSPLEAEFQR LPSYRSWRTQ HIGNQEENKS KNRNSNVIPY DFNRVPLKHE        60
     LEMSKESEHD SDESSDDDSD SEEXSKYINA SFIMXXWKPE VMIAAQGPLX ETIGDFWQMI       120
     FQRKVKVIVM LTELKHGDQE ICAQYWGEGK QTYGDIEVDL KDTDKSSTYT LRVFELRHSK       180
     RKDSRTVYQY QYTNWSVXXL PAXPKELISM IQVXKQKLPQ KNSSEGNKXH KSXPLLIHCR       240
     DGSQQTGIFC ALLNLLESAE TEEVVDXFQV VKALRKARPG MXSTFEQXQF LYDXIASTYP       300
//
ID   bIA2_D1\(P56722)\PTPRN STANDARD;PRT;   279 AA.
AC   P56722;
DT   17-MAY-2003
DE   Protein-tyrosine phosphatase-like N precursor (R-PTP-N) (Islet cell autoantigen 512) (ICA512).
KW   Receptor; Glycoprotein; Signal; Transmembrane.
OS   Bos taurus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovoidea; Bovidae; Bovinae; Bos.
CC   -------------------------------------------------------------------
CC   This SWISS-PROT entry is copyright. It is produced through a
CC   collaboration between the Swiss Institute of Bioinformatics and
CC   the EMBL outstation - the European Bioinformatics Institute.
CC   The original entry is available from http://www.expasy.ch/sprot
CC   and http://www.ebi.ac.uk/sprot
CC   ------------------------------------------------------------------.
CC   [FUNCTION] Implicated in neuroendocrine secretory processes. May be
CC   involved in processes specific for neurosecretory granules, such as
CC   their biogenesis, trafficking or regulated exocytosis or may have a
CC   general role in neuroendocrine functions. Lacks intrinsic enzyme
CC   activity. May play a role in the regulation of secretory granules
CC   via its interaction with SNTB2 (By similarity).
CC   [SUBUNIT] Interacts with phosphorylated SNTB2, protecting it from
CC   protein cleavage by CAPN1. Dephosphorylation of SNTB2 upon insulin
CC   stimulation disrupts the interaction and results in its cleavage
CC   (By similarity).
CC   [SUBCELLULAR LOCATION] Type I membrane protein. Neuroendocrine
CC   secretory granules.
CC   [PTM] N-glycosylated.
CC   [SIMILARITY] CONTAINS 1 PROTEIN-TYROSINE PHOSPHATASE DOMAIN.
CC   GPRFLN|REFERENCE   1  (residues 1 to 979)
CC   GPRFLN|  AUTHORS   Hermel,J.-M., Dirkx,R. and Solimena,M.
CC   GPRFLN|  TITLE     Direct Submission
CC   GPRFLN|  JOURNAL   Submitted (~JUN-1999)
CC   GPRFLN|  REMARK    SEQUENCE FROM N.A.
CC   GPRFLN|REFERENCE   2  (residues 1 to 979)
CC   GPRFLN|  AUTHORS   Hermel,J.M., Dirkx,R. Jr. and Solimena,M.
CC   GPRFLN|  TITLE     Post-translational modifications of ICA512, a receptor tyrosine
CC   GPRFLN|            phosphatase-like protein of secretory granules
CC   GPRFLN|  JOURNAL   Eur. J. Neurosci. 11 (8), 2609-2620 (1999)
CC   GPRFLN|  MEDLINE   99388259
CC   GPRFLN|  REMARK    SEQUENCE OF N-TERMINUS, AND CHARACTERIZATION.
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302454273|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    279       VNTIFKEY:269
FT   PROTEIN       1    279       VNTIFKEY:270
FT   CHAIN         1    279       PROTEIN-TYROSINE PHOSPHATASE-LIKE N.
FT                                VNTIFKEY:203; VNTINAME:PTPRN
FT   DOMAIN        1    279       CYTOPLASMIC (POTENTIAL).
FT                                VNTIFKEY:1004; VNTINAME:PTPRN
FT   DOMAIN        4    279       PROTEIN-TYROSINE PHOSPHATASE-LIKE.
FT                                VNTIFKEY:1000; VNTINAME:PTPRN
FT   ACT_SITE    217    217       BY SIMILARITY.
FT                                VNTIFKEY:220; VNTINAME:PTPRN
SQ   SEQUENCE   279 AA;
     HMILAYMEDH LRNRDRLAKE WQALCAYQAE PNTCATAQGE GNIKKNRHPD FLPYDHARIK        60
     LKVESSPSRS DYINASPIIE HDPRMPAYIA TQGPLSHTIA DFWQMVWESG CTVIVMLTPL       120
     VEDGVKQCDR YWPDEGSSLY HVYEVNLVSE HIWCEDFLVR SFYLKNVQTQ ETRTLTQFHF       180
     LSWPAEGTPA STRPLLDFRR KVNKCYRGRS CPIIVHCSDG AGRTGTYILI DMVLNRMAKG       240
     VKEIDIAATL EHVRDQRPGL VRSKDQFEFA LTAVAEEVN                              279
//
ID   bPTPBA14_D1\(NP_777015)\PTPN13 STANDARD;PRT;   275 AA.
AC   NP_777015;
DT   2-JUL-2003
DE   protein tyrosine phosphatase, non-receptor type 13 [APO-1/CD95 (Fas)-associated phosphatase] [Bos taurus].
OS   Bos taurus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovoidea; Bovidae; Bovinae; Bos.
CC   PROVISIONAL REFSEQ: This record has not yet been subject to final
CC   NCBI review. The reference sequence was derived from U20807.1.
CC   GPRFLN|REFERENCE   1  (residues 1 to 2484)
CC   GPRFLN|  AUTHORS   Vega,Q.C., Walton,K.M. and Dixon,J.E.
CC   GPRFLN|  TITLE     Tyrosine Phosphatases and the Cytoskeleton
CC   GPRFLN|  JOURNAL   Unpublished
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|307067825|

CC   VNTAUTHORNAME|JNA|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    275       VNTIFKEY:269
FT   PROTEIN       1    275       VNTIFKEY:270
FT   REGION       20    274       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_2
SQ   SEQUENCE   275 AA;
     AKLKSVIRML RGLLDQGIPS KELENLQELK PLDQCLIGQT KENRRKNRYK NILPYDATRV        60
     PLGDEGGYIN ASFIKIPVGR EEFVYIACQG PLPTTVGDFW QMIWEQNSSV IAMMTQEVEG       120
     EKIKCQRYWP NVLGKSTMVS NRLRLALVRV QQLKGFVVRA MTLEDIQTGE VRHVSHLNFT       180
     AWPDHDTPSQ PDDLLTFISY MRHVHRSGPI ITHCSAGIGR SGTLICIDVV LGLISQDLEF       240
     DISDLVRCMR LQRHGMVQTE DQYIFCYQVI LYVLT                                  275
//
ID   cCD45_D1\(A54080) STANDARD;   PRT;   279 AA.
AC   A54080;
DT   17-MAY-2003
DE   protein-tyrosine-phosphatase (EC 3.1.3.48), receptor type delta precursor - chicken.
KW   phosphoprotein; phosphoric monoester hydrolase; tyrosine-specific phosphatase.
OS   Gallus gallus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1237)
CC   GPRFLN|  AUTHORS   Fang,K.S., Barker,K., Sudol,M. and Hanafusa,H.
CC   GPRFLN|  TITLE     A transmembrane protein-tyrosine phosphatase contains spectrin-like
CC   GPRFLN|            repeats in its extracellular domain
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 269 (19), 14056-14063 (1994)
CC   GPRFLN|  MEDLINE   94245724
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302463475|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    279       VNTIFKEY:269
FT   PROTEIN       1    279       VNTIFKEY:270
FT   DOMAIN        1    279       leukocyte common antigen cytosolic domain homology #label LAC
FT                                VNTIFKEY:1000; VNTINAME:LAC
FT   DOMAIN       42    266       protein-tyrosine-phosphatase homology #label PTP
FT                                VNTIFKEY:1000; VNTINAME:PTP
FT   ACT_SITE    218    218       Cys (phosphocysteine intermediate)
FT                                VNTIFKEY:220; VNTINAME:Active_Site_1
FT   BINDING     224    224       substrate phosphate (Arg)
FT                                VNTIFKEY:1007; VNTINAME:Binding_1
SQ   SEQUENCE   279 AA;
     EKLLETYKRK IADEGRLFLD EFQSIPRIFT KFPMKEAKRS HNQNKNRYID ILPYDHNRVE        60
     LSEIPGDPGS DYINASYIDG FKEPRKYIAA QGPKDETTDD FWRMIWEQKA TIIVMVTRCE       120
     EGNRNKCAQY GPSMENGSAT YGDITVKINE SKICPDYIIQ KLHITNGRER TSGRDVTHIQ       180
     FTSWPDHGVP EDPHLLLKLR RRVNALSNFF SGPIVVHCSA GVGRTGTYIG IDAMLEGLDA       240
     EGRVDVYGYV VKLRRQRCLM VQVESQYILI HQALVEYHQ                              279
//
ID   cCD45_D2\(A54080) STANDARD;   PRT;   308 AA.
AC   A54080;
DT   17-MAY-2003
DE   protein-tyrosine-phosphatase (EC 3.1.3.48), receptor type delta precursor - chicken.
KW   phosphoprotein; phosphoric monoester hydrolase; tyrosine-specific phosphatase.
OS   Gallus gallus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1237)
CC   GPRFLN|  AUTHORS   Fang,K.S., Barker,K., Sudol,M. and Hanafusa,H.
CC   GPRFLN|  TITLE     A transmembrane protein-tyrosine phosphatase contains spectrin-like
CC   GPRFLN|            repeats in its extracellular domain
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 269 (19), 14056-14063 (1994)
CC   GPRFLN|  MEDLINE   94245724
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302464996|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    308       VNTIFKEY:269
FT   PROTEIN       1    308       VNTIFKEY:270
FT   DOMAIN        1    308       leukocyte common antigen cytosolic domain homology #label LAC
FT                                VNTIFKEY:1000; VNTINAME:LAC
SQ   SEQUENCE   308 AA;
     SELHSYLNNL KRKDPPSEPS LLEAKFQRLP SYKGWRTQNT GNREENKNKN RSANTIPYDF        60
     NRVPIRSEEE QSKEGEHDSE DSSDEDSDCE ESSRYINASF ITGYWGPKAM IATQGPLQET       120
     ISDFWQMVFQ RKVKVIVMLT ELKEGDQELC AQYWGEGRQT YDDIEVQVTD VNCCPSYTIR       180
     AFDVTHLKRK ETQKVYQYQY HKWNGLDVPE DPKDLVDMIL SLKQKVPSRP ASEDSRNSRS       240
     VPFVIHCCDG SQQTWCVLCL MTLLESAETE EVIDVFQVVK ALRRSRLGVV STFEQYQFLY       300
     DTIARTYP                                                                308
//
ID   cDEP1_D1\(CAB41885) STANDARD; PRT;   277 AA.
AC   CAB41885;
DT   27-JUN-2003
DE   supporting-cell antigen [Gallus gallus].
OS   Gallus gallus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
CC   On Jun 28, 2001 this sequence version replaced gi:4741401.
CC   GPRFLN|REFERENCE   1
CC   GPRFLN|  AUTHORS   Kruger,R.P., Goodyear,R.J., Legan,P.K., Warchol,M.E., Raphael,Y.,
CC   GPRFLN|            Cotanche,D.A. and Richardson,G.P.
CC   GPRFLN|  TITLE     The supporting-cell antigen: a receptor-like protein tyrosine
CC   GPRFLN|            phosphatase expressed in the sensory epithelia of the avian inner
CC   GPRFLN|            ear
CC   GPRFLN|  JOURNAL   J. Neurosci. 19 (12), 4815-4827 (1999)
CC   GPRFLN|  MEDLINE   99296852
CC   GPRFLN|REFERENCE   2
CC   GPRFLN|  AUTHORS   Legan,P.K.
CC   GPRFLN|  TITLE     Direct Submission
CC   GPRFLN|  JOURNAL   Submitted (26-APR-1999) Legan P.K., School of Biological Sciences,
CC   GPRFLN|            University of Sussex, Falmer, Brighton, BN1 9QG, UNITED KINGDOM
CC   GPRFLN|  REMARK    Revised by [3]
CC   GPRFLN|REFERENCE   3  (residues 1 to 1406)
CC   GPRFLN|  AUTHORS   Legan,P.K.
CC   GPRFLN|  TITLE     Direct Submission
CC   GPRFLN|  JOURNAL   Submitted (27-JUN-2001) Legan P.K., School of Biological Sciences,
CC   GPRFLN|            University of Sussex, Falmer, Brighton, BN1 9QG, UNITED KINGDOM
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302465246|

CC   VNTAUTHORNAME|JNA|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    277       VNTIFKEY:269
FT   PROTEIN       1    277       VNTIFKEY:270
SQ   SEQUENCE   277 AA;
     ENFESYFKKQ QADSNCGFAE EYEELKSAGV HQPKFAAEIA ENRGKNRYNN VLPYDISRVK        60
     LSNPSCTTDD YINANYMPGY SSKKAFIAAQ GPLPNTIEDF WRMIWEKNIY SIVMLTKCVE       120
     QARTKCEQYW PDKQSKSYGD IIVTMVSEVV LPEWTIRDFN VENADTMESH TVRQFHFTSW       180
     PDHGVPETTD LLINFRHLVH EYSSQNPIDS PILVHCSAGV GRTGTFIAID RLIQQIEMEN       240
     TVDVYGVVYD LRMHRPLMVQ TEDQYVFLNQ CVMDIIR                                277
//
ID   cGLEPP1_D1\(AAB17968) STANDARD;PRT;   277 AA.
AC   AAB17968;
DT   27-JUN-2003
DE   protein tyrosine phosphatase CRYP-2 [Gallus gallus].
OS   Gallus gallus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
CC   Method: conceptual translation.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1267)
CC   GPRFLN|  AUTHORS   Bodden,K. and Bixby,J.L.
CC   GPRFLN|  TITLE     CRYP-2: a receptor-type tyrosine phosphatase selectively expressed
CC   GPRFLN|            by developing vertebrate neurons
CC   GPRFLN|  JOURNAL   J. Neurobiol. 31 (3), 309-324 (1996)
CC   GPRFLN|  MEDLINE   97067376
CC   GPRFLN|REFERENCE   2  (residues 1 to 1267)
CC   GPRFLN|  AUTHORS   Bodden,K. and Bixby,J.L.
CC   GPRFLN|  TITLE     Direct Submission
CC   GPRFLN|  JOURNAL   Submitted (01-AUG-1996) Pharmacology, University of Miami, 1600 NW
CC   GPRFLN|            10 Ave, Miami, FL 33136, USA
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302465459|

CC   VNTAUTHORNAME|JNA|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    276       VNTIFKEY:269
FT   PROTEIN       1    276       VNTIFKEY:270
SQ   SEQUENCE   277 AA;
     DDFDGYIKDM AKDSDYKFSL QFEELKLIGL DIPHFAADLP MNRCKNRYTN ILPYDFSRVR        60
     LVSMNEEEGS DYINANYIPG YNSPQEYIAT QGPLPETRND FWKMVLQQKS QIIVMLTQCN       120
     EKRRVKCDHY WPFTEDPIAY GDITVEMLSE EEHTDWVYRN FRISYADEVQ DVMHFNYTAW       180
     PDHGVPTANA AESILQFVQM VRQKSVKSKG PMIIHCSAGV GRTGTFIALD WLLQHIRDHE       240
     FVDILGLVSD MRSYRMSMVQ TEEQYIFIHQ CVQLMWQ                                277
//
ID   cMG-PTP1_D1\(AAB33980)_Fragm STANDARD;PRT;   81 AA.
AC   AAB33980;
DT   28-JUN-2003
DE   Muller glia protein tyrosine phosphatase 1, MG-PTP1 [chickens, retinas, Muller glia cells, Peptide Partial, 81 aa].
OS   Gallus gallus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
CC   Method: conceptual translation supplied by author.
CC   GPRFLN|REFERENCE   1  (residues 1 to 81)
CC   GPRFLN|  AUTHORS   Shock,L.P., Bare,D.J., Klinz,S.G. and Maness,P.F.
CC   GPRFLN|  TITLE     Protein tyrosine phosphatases expressed in developing brain and
CC   GPRFLN|            retinal Muller glia
CC   GPRFLN|  JOURNAL   Brain Res. Mol. Brain Res. 28 (1), 110-116 (1995)
CC   GPRFLN|  MEDLINE   95223107
CC   GPRFLN|  REMARK    GenBank staff at the National Library of Medicine created this
CC   GPRFLN|            entry [NCBI gibbsq 165661] from the original journal article.
CC   GPRFLN|            This sequence comes from Fig. 2C.
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|0|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1     81       VNTIFKEY:269
FT   PROTEIN       1     81       MG-PTP1
FT                                VNTIFKEY:270
SQ   SEQUENCE   81 AA;
     GRGTDTYGMI QVTLLDTIEL ATFCVRTFSL HKNGSSKKRE VRQFQFTAWP DHGVPEYPTP        60
     FLAFLRRVKT CNPPDAGPIV V                                                  81
//
ID   cMG-PTP2_D1\(AAB33981)_Fragm STANDARD;PRT;   87 AA.
AC   AAB33981;
DT   26-JUN-2003
DE   Muller glia protein tyrosine phosphatase 2, MG-PTP2 {MG-PTP2 catalytic domain} [chickens, retinas, Muller glia cells, Peptide Partial, 87 aa].
OS   Gallus gallus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
CC   Method: conceptual translation supplied by author.
CC   GPRFLN|REFERENCE   1  (residues 1 to 87)
CC   GPRFLN|  AUTHORS   Shock,L.P., Bare,D.J., Klinz,S.G. and Maness,P.F.
CC   GPRFLN|  TITLE     Protein tyrosine phosphatases expressed in developing brain and
CC   GPRFLN|            retinal Muller glia
CC   GPRFLN|  JOURNAL   Brain Res. Mol. Brain Res. 28 (1), 110-116 (1995)
CC   GPRFLN|  MEDLINE   95223107
CC   GPRFLN|  REMARK    GenBank staff at the National Library of Medicine created this
CC   GPRFLN|            entry [NCBI gibbsq 165663] from the original journal article.
CC   GPRFLN|            This sequence comes from Fig. 2D.
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|0|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1     87       VNTIFKEY:269
FT   PROTEIN       1     87       MG-PTP2
FT                                VNTIFKEY:270
SQ   SEQUENCE   87 AA;
     TRGEEVMVFS ETGFRVRLVS EDIKSYYTVH LLQLENINSG ESRMISHFHY TTWPDFGVPE        60
     SPASFLNFLF KVRESGCLSP EHGPAVD                                            87
//
ID   cPTP-NT1subtype_D1\(AAA49018)_Fragm STANDARD;PRT;   62 AA.
AC   AAA49018;
DT   28-JUN-2003
DE   phosphoprotein phosphatase.
OS   Gallus gallus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
CC   Method: conceptual translation.
CC   GPRFLN|REFERENCE   1  (residues 1 to 62)
CC   GPRFLN|  AUTHORS   Potts,J.D.
CC   GPRFLN|  TITLE     Protein tyrosine phosphatases isolated from embryonic chicken lens
CC   GPRFLN|            epithelium
CC   GPRFLN|  JOURNAL   Unpublished (1993)
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|306551667|

CC   VNTAUTHORNAME|JNA|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|UNKNOWN|
FT   SOURCE        1     62       VNTIFKEY:269
FT   PROTEIN       1     62       VNTIFKEY:270
SQ   SEQUENCE   62 AA;
     GSDYINASLI KMEEAQRSYI LTQGPLPNTC GHFWEMVWEQ KSRGVVMLNR VMEKGSIKCD        60
     QY                                                                       62
//
ID   cPTP-NT1subtype_D1\(AAA49019)_Fragm STANDARD;PRT;   63 AA.
AC   AAA49019;
DT   26-JUN-2003
DE   phosphoprotein phosphatase.
OS   Gallus gallus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
CC   Method: conceptual translation.
CC   GPRFLN|REFERENCE   1  (residues 1 to 63)
CC   GPRFLN|  AUTHORS   Potts,J.D.
CC   GPRFLN|  TITLE     Protein tyrosine phosphatases isolated from embryonic chicken lens
CC   GPRFLN|            epithelium
CC   GPRFLN|  JOURNAL   Unpublished (1993)
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|0|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1     63       VNTIFKEY:269
FT   PROTEIN       1     63       VNTIFKEY:270
SQ   SEQUENCE   63 AA;
     GSDYINASLV VIEEAQRYYI LTQGPLPNTC CHFWLMVWQQ QTKAVVMLNR IVEKDSVKCA        60
     QYW                                                                      63
//
ID   cPTP-R2Asubtype_D1\(AAA49017)_Fragm STANDARD;PRT;   63 AA.
AC   AAA49017;
DT   28-JUN-2003
DE   phosphoprotein phosphatase.
OS   Gallus gallus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
CC   Method: conceptual translation.
CC   GPRFLN|REFERENCE   1  (residues 1 to 63)
CC   GPRFLN|  AUTHORS   Potts,J.D.
CC   GPRFLN|  TITLE     Protein tyrosine phosphatases isolated from embryonic chicken lens
CC   GPRFLN|            epithelium
CC   GPRFLN|  JOURNAL   Unpublished (1993)
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|0|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1     63       VNTIFKEY:269
FT   PROTEIN       1     63       VNTIFKEY:270
SQ   SEQUENCE   63 AA;
     GSDYINASSI DGYRQQKAYI ATQGPLAETT EDFWWMLWEN NSTIVVMLTK LREMGREKCA        60
     QYW                                                                      63
//
ID   cPTP-R2Bsubtype_D1\(AAA49016)_Fragm STANDARD;PRT;   63 AA.
AC   AAA49016;
DT   26-JUN-2003
DE   phosphoprotein phosphatase.
OS   Gallus gallus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
CC   Method: conceptual translation.
CC   GPRFLN|REFERENCE   1  (residues 1 to 63)
CC   GPRFLN|  AUTHORS   Potts,J.D.
CC   GPRFLN|  TITLE     Protein tyrosine phosphatases isolated from embryonic chicken lens
CC   GPRFLN|            epithelium
CC   GPRFLN|  JOURNAL   Unpublished (1993)
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|0|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1     63       VNTIFKEY:269
FT   PROTEIN       1     63       VNTIFKEY:270
SQ   SEQUENCE   63 AA;
     GSDYMNANYI DGYHRSNHFI ATQGPKQEMV YDFWRMVWQE HCSSIVMITK LVEVGRVKCA        60
     QYW                                                                      63
//
ID   cPTP1B_D1\(O13016) STANDARD;  PRT;   279 AA.
AC   O13016;
DT   17-MAY-2003
DE   Protein-tyrosine phosphatase, non-receptor type 1 (Protein-tyrosine phosphatase 1B) (PTP-1B) (CPTP1).
KW   Hydrolase.
OS   Gallus gallus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
CC   -------------------------------------------------------------------
CC   This SWISS-PROT entry is copyright. It is produced through a
CC   collaboration between the Swiss Institute of Bioinformatics and
CC   the EMBL outstation - the European Bioinformatics Institute.
CC   The original entry is available from http://www.expasy.ch/sprot
CC   and http://www.ebi.ac.uk/sprot
CC   ------------------------------------------------------------------.
CC   [CATALYTIC ACTIVITY] PROTEIN TYROSINE PHOSPHATE + H(2)O = PROTEIN
CC   TYROSINE + ORTHOPHOSPHATE.
CC   [SUBCELLULAR LOCATION] ASSOCIATED TO THE ENDOPLASMIC RETICULUM VIA
CC   ITS C-TERMINAL DOMAIN WITH ITS PHOSPHATASE DOMAIN ORIENTED TOWARDS
CC   THE CYTOPLASM (BY SIMILARITY).
CC   [SIMILARITY] BELONGS TO THE NON-RECEPTOR CLASS OF THE
CC   PROTEIN-TYROSINE PHOSPHATASE FAMILY.
CC   GPRFLN|REFERENCE   1  (residues 1 to 434)
CC   GPRFLN|  AUTHORS   Balsamo,J., Leung,T., Ernst,H., Zanin,M.K., Hoffman,S. and
CC   GPRFLN|            Lilien,J.
CC   GPRFLN|  TITLE     Regulated binding of PTP1B-like phosphatase to N-cadherin: control
CC   GPRFLN|            of cadherin-mediated adhesion by dephosphorylation of beta-catenin
CC   GPRFLN|  JOURNAL   J. Cell Biol. 134 (3), 801-813 (1996)
CC   GPRFLN|  MEDLINE   96326683
CC   GPRFLN|  REMARK    SEQUENCE FROM N.A.
CC   GPRFLN|            TISSUE=Retina
CC   GPRFLN|REFERENCE   2  (residues 1 to 434)
CC   GPRFLN|  AUTHORS   Kim,C.W., Jung,E.J. and Kang,Y.-S.
CC   GPRFLN|  TITLE     Cloning and characterization of a chicken protein tyrosine
CC   GPRFLN|            phosphatase, CPTP1
CC   GPRFLN|  JOURNAL   Exp. Mol. Med. 28, 207-213 (1996)
CC   GPRFLN|  REMARK    SEQUENCE OF 14-369 FROM N.A.
CC   GPRFLN|            TISSUE=Intestine
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302464650|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    279       VNTIFKEY:269
FT   PROTEIN       1    279       VNTIFKEY:270
FT   CONFLICT      ?      ?       A -> R (IN REF. 2).
FT                                VNTIFKEY:240; VNTINAME:PTPN1
FT   DOMAIN       40    279       PROTEIN-TYROSINE PHOSPHATASE.
FT                                VNTIFKEY:1000; VNTINAME:PTPN1
FT   CONFLICT     62     63       GD -> RC (IN REF. 2).
FT                                VNTIFKEY:240; VNTINAME:PTPN1
FT   ACT_SITE      ?      ?       VNTIFKEY:220; VNTINAME:PTPN1
SQ   SEQUENCE   279 AA;
     MEIEKEFHRL DQAASWAAIY QDIRHEASDF PCKVAKHPRN KNRNRYRDVS PFDHSRIKLN        60
     QGDNDYINAS LIKMEEAQRS YILTQGPLPN TCGHFWEMVW EQKSRGVVML NRVMEKGSIK       120
     CAQYWPRKEE KEMFFEDTNL KLTLISEDIK SYYTVRQLEL ENLTTQETRE ILHFHYTTWP       180
     DFGVPESPAS FLNFLFKVRE SGSLNPEYGP VVVHCSAGIG RSGTFCLVDT CLLLMDKRKD       240
     PSSVDVKQVL LEMRKYRMGL IQTADQLRFS YLAVIEGAK                              279
//
ID   cPTPalpha_D1\(AAB04150) STANDARD;PRT;   280 AA.
AC   AAB04150;
DT   17-MAY-2003
DE   protein tyrosine phosphatase.
OS   Gallus gallus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
CC   Method: conceptual translation.
CC   GPRFLN|REFERENCE   1  (residues 1 to 807)
CC   GPRFLN|  AUTHORS   Fang,K.S.
CC   GPRFLN|  TITLE     Structural and functional characterization of two chicken tyrosine
CC   GPRFLN|            phosphatases
CC   GPRFLN|  JOURNAL   Thesis (1993)
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302463254|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    280       VNTIFKEY:269
FT   PROTEIN       1    280       VNTIFKEY:270
FT   CHAIN         1    280       VNTIFKEY:203; VNTINAME:Chain_1
SQ   SEQUENCE   280 AA;
     DKLEEEINRR IGDDNKLFRE EFNALPACPI QATCEAASKE ENKEKNRYVN ILPYDHSRVH        60
     LTPVEGVPDS HYINTSFINS YQEKNKFIAA QGPKEETVND FWRMIWEQNT ATIVMVTNLK       120
     ERKECKCAQY WPDQGCWTYG NIRVSVEDVT VLVDYTVRKF CIQQVGDVTN KKPQRLVTQF       180
     HFTSWPDFGV PFTPIGMLKF LKKVKTCNPQ YAGAIVVHCS AGVGRTGTFI VIDAMLDMMH       240
     AERKVDVYGF VSRIRAQRCQ MVQTDMQYVF IYQALLEHYL                             280
//
ID   cPTPalpha_D2\(AAB04150) STANDARD;PRT;   281 AA.
AC   AAB04150;
DT   17-MAY-2003
DE   protein tyrosine phosphatase.
OS   Gallus gallus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
CC   Method: conceptual translation.
CC   GPRFLN|REFERENCE   1  (residues 1 to 807)
CC   GPRFLN|  AUTHORS   Fang,K.S.
CC   GPRFLN|  TITLE     Structural and functional characterization of two chicken tyrosine
CC   GPRFLN|            phosphatases
CC   GPRFLN|  JOURNAL   Thesis (1993)
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302464946|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    281       VNTIFKEY:269
FT   PROTEIN       1    281       VNTIFKEY:270
FT   CHAIN         1    281       VNTIFKEY:203; VNTINAME:Chain_1
SQ   SEQUENCE   281 AA;
     TSLEIHLQKI YNKVPGTSSN GLEEEFKKLT SIKIQNDKMR TGNLPANMKK NRVLQIIPYE        60
     FNRVIIPVKR GEENTDYVNA SFIDGYRRRT PTCQPRPVQH TIEDFWRMIW EWKSCSIVML       120
     TELEERGQEK CAQYWPSDGS VSYGDINVEL KKEEECESYT VRDLLVTNTR ENKSRQIRQF       180
     HFHGWPEVGI PSDGKGMINI IAAVQKQQQQ SGNHPMHCHC SAGAGRTGTF CALSTVLERV       240
     KAEGILDVFQ TVKSLRLQRP HMVQTLEQYE FCYKVVQEYI D                           281
//
ID   cPTPgamma_D1\(Q98936) STANDARD;PRT;   291 AA.
AC   Q98936;
DT   17-MAY-2003
DE   Protein-tyrosine phosphatase gamma precursor (R-PTP-gamma).
KW   Glycoprotein; Transmembrane; Hydrolase; Repeat; Signal.
OS   Gallus gallus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
CC   -------------------------------------------------------------------
CC   This SWISS-PROT entry is copyright. It is produced through a
CC   collaboration between the Swiss Institute of Bioinformatics and
CC   the EMBL outstation - the European Bioinformatics Institute.
CC   The original entry is available from http://www.expasy.ch/sprot
CC   and http://www.ebi.ac.uk/sprot
CC   ------------------------------------------------------------------.
CC   [CATALYTIC ACTIVITY] Protein tyrosine phosphate + H(2)O = protein
CC   tyrosine + phosphate.
CC   [SUBCELLULAR LOCATION] Type I membrane protein (Probable).
CC   [SIMILARITY] IN THE N-TERMINAL SECTION; BELONGS TO THE
CC   EUKARYOTIC-TYPE CARBONIC ANHYDRASE FAMILY.
CC   [SIMILARITY] CONTAINS 2 PROTEIN-TYROSINE PHOSPHATASE DOMAINS.
CC   [SIMILARITY] CONTAINS 1 FIBRONECTIN TYPE III-LIKE DOMAIN.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1422)
CC   GPRFLN|  AUTHORS   Qinghua,X., Xiaojun,G., Cong,S., Zong,S.M., Jong,Y.J., Chan,J. and
CC   GPRFLN|            Wang,L.-H.
CC   GPRFLN|  TITLE     Direct Submission
CC   GPRFLN|  JOURNAL   Submitted (~OCT-1995)
CC   GPRFLN|  REMARK    SEQUENCE FROM N.A.
CC   GPRFLN|            TISSUE=Brain, and Kidney
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302464404|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    291       VNTIFKEY:269
FT   PROTEIN       1    291       VNTIFKEY:270
FT   CHAIN         1    291       PROTEIN-TYROSINE PHOSPHATASE GAMMA.
FT                                VNTIFKEY:203; VNTINAME:PTPRG
FT   DOMAIN        1    291       CYTOPLASMIC (POTENTIAL).
FT                                VNTIFKEY:1004; VNTINAME:PTPRG
FT   DOMAIN       39    291       PROTEIN-TYROSINE PHOSPHATASE 1.
FT                                VNTIFKEY:1000; VNTINAME:PTPRG
FT   ACT_SITE    230    230       BY SIMILARITY.
FT                                VNTIFKEY:220; VNTINAME:PTPRG
SQ   SEQUENCE   291 AA;
     KQFVKHISEL YSNNQHGFSE DFEEVQRCTA DMNITAEHSN HPDNKHKNRY INILAYDHSR        60
     VKLRPLPGKD SKHSDYINAN YVSGYNKAKA YIATQGPLKS TFEDFWRMIW AQHTGIIVMI       120
     TNLVEKGRRK CDQYWPTENS EEYGNIIVTL KSTNIHACYT VRPLHGQEHK DEKGSERKPK       180
     GRQNERTVIQ YHYTQWPDMG VPEYALPVLT FVRRSSAART PHMGPVVVHC SAGVGRTGTY       240
     IVIDSMLQQI KDKSTVNVLG FLKHIRTQRN YLVQTEEQYI FIHDALLEAI L                291
//
ID   cPTPgamma_D2\(Q98936) STANDARD;PRT;   283 AA.
AC   Q98936;
DT   27-JUN-2003
DE   Protein-tyrosine phosphatase gamma precursor (R-PTP-gamma).
KW   Glycoprotein; Transmembrane; Hydrolase; Repeat; Signal.
OS   Gallus gallus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
CC   -------------------------------------------------------------------
CC   This SWISS-PROT entry is copyright. It is produced through a
CC   collaboration between the Swiss Institute of Bioinformatics and
CC   the EMBL outstation - the European Bioinformatics Institute.
CC   The original entry is available from http://www.expasy.ch/sprot
CC   and http://www.ebi.ac.uk/sprot
CC   ------------------------------------------------------------------.
CC   [CATALYTIC ACTIVITY] Protein tyrosine phosphate + H(2)O = protein
CC   tyrosine + phosphate.
CC   [SUBCELLULAR LOCATION] Type I membrane protein (Probable).
CC   [SIMILARITY] IN THE N-TERMINAL SECTION; BELONGS TO THE
CC   EUKARYOTIC-TYPE CARBONIC ANHYDRASE FAMILY.
CC   [SIMILARITY] CONTAINS 2 PROTEIN-TYROSINE PHOSPHATASE DOMAINS.
CC   [SIMILARITY] CONTAINS 1 FIBRONECTIN TYPE III-LIKE DOMAIN.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1422)
CC   GPRFLN|  AUTHORS   Qinghua,X., Xiaojun,G., Cong,S., Zong,S.M., Jong,Y.J., Chan,J. and
CC   GPRFLN|            Wang,L.-H.
CC   GPRFLN|  TITLE     Direct Submission
CC   GPRFLN|  JOURNAL   Submitted (~OCT-1995)
CC   GPRFLN|  REMARK    SEQUENCE FROM N.A.
CC   GPRFLN|            TISSUE=Brain, and Kidney
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302464892|

CC   VNTAUTHORNAME|JNA|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    283       VNTIFKEY:269
FT   PROTEIN       1    283       VNTIFKEY:270
FT   CHAIN         1    283       PROTEIN-TYROSINE PHOSPHATASE GAMMA.
FT                                VNTIFKEY:203; VNTINAME:PTPRG
FT   DOMAIN        1    283       CYTOPLASMIC (POTENTIAL).
FT                                VNTIFKEY:1004; VNTINAME:PTPRG
FT   DOMAIN        1    283       PROTEIN-TYROSINE PHOSPHATASE 2.
FT                                VNTIFKEY:1000; VNTINAME:PTPRG
FT   SITE        222    222       ANCESTRAL ACTIVE SITE.
FT                                VNTIFKEY:265; VNTINAME:PTPRG
SQ   SEQUENCE   283 AA;
     NQLHSYVNSI LIPGIGGKTR LEKQFKLVTQ CNAKYVECFS AQKDCNKEKN RNSSVVPSER        60
     ARVGLAPLPG MKGTDYINAS YIMGYYRSNE NVITQHPLPH TTKDFWRMIW DHNAQIIVML       120
     PDNQSLAEDE FVYWPSREES MNCEAFTVTL ISKDRLCLSN EEQIIIHDFI LEATQDDYVL       180
     EVRHFQCPKW PNPDAPISST FELINVIKEE ALTRDGPTIV HDEYGAVSAG TLCALTTLSQ       240
     QLENENAVDV FQVAKMINLM RPGVFTDIEQ YQFLYKAMLS LVS                         283
//
ID   cPTPsigma_D1\(I50212) STANDARD;PRT;   275 AA.
AC   I50212;
DT   17-MAY-2003
DE   protein-tyrosine-phosphatase (EC 3.1.3.48) - chicken.
KW   phosphoprotein; phosphoric monoester hydrolase; tyrosine-specific phosphatase.
OS   Gallus gallus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1499)
CC   GPRFLN|  AUTHORS   Stoker,A.W.
CC   GPRFLN|  TITLE     Isoforms of a novel cell adhesion molecule-like protein tyrosine
CC   GPRFLN|            phosphatase are implicated in neural development
CC   GPRFLN|  JOURNAL   Mech. Dev. 46 (3), 201-217 (1994)
CC   GPRFLN|  MEDLINE   95001563
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302465303|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    275       VNTIFKEY:269
FT   PROTEIN       1    275       VNTIFKEY:270
FT   DOMAIN        1    275       leukocyte common antigen cytosolic domain homology #label LAC
FT                                VNTIFKEY:1000; VNTINAME:LAC
FT   ACT_SITE    214    214       Cys (phosphocysteine intermediate)
FT                                VNTIFKEY:220; VNTINAME:Active_Site_1
FT   BINDING     220    220       substrate phosphate (Arg)
FT                                VNTIFKEY:1007; VNTINAME:Binding_1
SQ   SEQUENCE   275 AA;
     SELAEHTEHL KANDNLKLSQ EYESIDPGQQ FTWEHSNLEV NKPKNRYANV IAYDHSRVIL        60
     LPIEGIVGSD YINANYIDGY RKQNAYIATQ GPLPETFGDF WRMVWEQRSA TIVMMTKLEE       120
     KSRIKCDQYW PGRGTDTYGM IQVTLLDTIE LATFCVRTFS LHKNGSSEKR EVRQFQFTAW       180
     PDHGVPEYPT PFLAFLRRVK TCNPPDAGPI VVHCSAGVGR TGCFIVIDAM LERIKHEKTV       240
     DIYGHVTLMR SQRNYMVQTE DQYSFIHDAL LEAVA                                  275
//
ID   cPTPsigma_D2\(I50212) STANDARD;PRT;   282 AA.
AC   I50212;
DT   27-JUN-2003
DE   protein-tyrosine-phosphatase (EC 3.1.3.48) - chicken.
KW   phosphoprotein; phosphoric monoester hydrolase; tyrosine-specific phosphatase.
OS   Gallus gallus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1499)
CC   GPRFLN|  AUTHORS   Stoker,A.W.
CC   GPRFLN|  TITLE     Isoforms of a novel cell adhesion molecule-like protein tyrosine
CC   GPRFLN|            phosphatase are implicated in neural development
CC   GPRFLN|  JOURNAL   Mech. Dev. 46 (3), 201-217 (1994)
CC   GPRFLN|  MEDLINE   95001563
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302465404|

CC   VNTAUTHORNAME|JNA|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    282       VNTIFKEY:269
FT   PROTEIN       1    282       VNTIFKEY:270
FT   DOMAIN        1    282       leukocyte common antigen cytosolic domain homology #label LAC
FT                                VNTIFKEY:1000; VNTINAME:LAC
FT   DOMAIN       47    269       protein-tyrosine-phosphatase homology #label PTP2
FT                                VNTIFKEY:1000; VNTINAME:PTP2
FT   ACT_SITE    222    222       Cys (phosphocysteine intermediate)
FT                                VNTIFKEY:220; VNTINAME:Active_Site_2
FT   BINDING     228    228       substrate phosphate (Arg)
FT                                VNTIFKEY:1007; VNTINAME:Binding_2
SQ   SEQUENCE   282 AA;
     RNLYTYIQKL AQIEVGEHVT GMELEFKRLA NSKAHTSRFI SANLPCNKFK NRLVNIMPYE        60
     TTRVCLQPIR GVEGSDYINA SFIDGYRQQK AYIATQGPLA ETTEDFWRML WENNSTIVVM       120
     LTKLREMGRE KCHQYWPAER SARYQYFVVD PMAEYNMPQY ILREFKVTDA RDGQSRTVRQ       180
     FQFTDWPEQG VPKSGEGFID FIGQVHKTKE QFGQDGPISV HCSAGVGRTG VFITLSIVLE       240
     RMRYEGVVDI FQTVKMLRTQ PAMVQTEDEY QFCYQAALEY LG                          282
//
ID   cPTPzeta_D1\(AAA49015) STANDARD;PRT;   286 AA.
AC   AAA49015;
DT   17-MAY-2003
DE   phosphotyrosyl phosphatase.
OS   Gallus gallus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
CC   Method: conceptual translation.
CC   GPRFLN|REFERENCE   1  (residues 1 to 832)
CC   GPRFLN|  AUTHORS   Rowley,R.B., Lee,J.M., Corbeil,H.B., Charbonneau,R., Jue,K.,
CC   GPRFLN|            Dankort,D.L. and Branton,P.E.
CC   GPRFLN|  TITLE     Isolation of chicken phosphotyrosyl phosphatase cDNA sequences and
CC   GPRFLN|            identification of a brain-specific species related to human PTP
CC   GPRFLN|            zeta
CC   GPRFLN|  JOURNAL   Cell. Mol. Biol. Res. 39 (3), 209-219 (1993)
CC   GPRFLN|  MEDLINE   94122757
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302464518|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    286       VNTIFKEY:269
FT   PROTEIN       1    286       VNTIFKEY:270
SQ   SEQUENCE   286 AA;
     KHFPKHVADL HASNGFSEEF EEIQSCTVDL GITSDSSNHP DNKNKNRYIN IVAYDHTRVK        60
     LAQLAEKDGK LTDYINANYV DGYNKPKAYI AAQGPLKSTA EDFWRMIWEH NVEVIVMITN       120
     LLEKGRRKCD QYWPAEGSEE YGNFLVTQKS VHVLAYYTVR NFTLRNTKIK KGSQKGRSSG       180
     RVVTQYHYTQ WPDMGVPEYT LPVLTFVRKA SHAKRHAVGP IVVHCSAGVG RTGTYVVLDS       240
     MLQQIQHEGT VNIFGFLKHI RTQRNYLVQT EEQYIFIHDA LVEAIL                      286
//
ID   cPTPzeta_D2\(AAA49015) STANDARD;PRT;   282 AA.
AC   AAA49015;
DT   27-JUN-2003
DE   phosphotyrosyl phosphatase.
OS   Gallus gallus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
CC   Method: conceptual translation.
CC   GPRFLN|REFERENCE   1  (residues 1 to 832)
CC   GPRFLN|  AUTHORS   Rowley,R.B., Lee,J.M., Corbeil,H.B., Charbonneau,R., Jue,K.,
CC   GPRFLN|            Dankort,D.L. and Branton,P.E.
CC   GPRFLN|  TITLE     Isolation of chicken phosphotyrosyl phosphatase cDNA sequences and
CC   GPRFLN|            identification of a brain-specific species related to human PTP
CC   GPRFLN|            zeta
CC   GPRFLN|  JOURNAL   Cell. Mol. Biol. Res. 39 (3), 209-219 (1993)
CC   GPRFLN|  MEDLINE   94122757
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302464822|

CC   VNTAUTHORNAME|JNA|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    282       VNTIFKEY:269
FT   PROTEIN       1    282       VNTIFKEY:270
SQ   SEQUENCE   282 AA;
     THIHAYVNAL LIPGPTGKTR LEKQFKLLSQ SNTQQCDYST ALKQCNREKN RTSSIIPVER        60
     SRVGISSLSG EGTDYINASY IMGYYQSNEF IITQHPLLHT IKDFWRMIWD HNAQLIVMLP       120
     DSQNMAEDEF VYWPNKDEPI NCETFKVTMI AEEHKCLSKE EKLIIQDFIL EATQDDYVLE       180
     VRHFQCPKWP NPDSPISKTF ELISIIKEET SNRDGPMIVH DEHGGVTAGT FCALTTLMHQ       240
     LENENSVDVY QVAKMINLMR PGVFTDIEQY QFLYKAILSL VS                          282
//
ID   cSHP2_D1\(JC5167) STANDARD;   PRT;   300 AA.
AC   JC5167;
DT   17-MAY-2003
DE   protein-tyrosine-phosphatase (EC 3.1.3.48), nonreceptor type 11 - chicken.
KW   phosphoprotein; phosphoric monoester hydrolase; tyrosine-specific phosphatase.
OS   Gallus gallus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
CC   This enzyme plays positive roles in mitogenic signaling and early
CC   development.
CC   GPRFLN|REFERENCE   1  (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Park,C.Y., LaMontagne,K.R., Tonks,N.K. and Hayman,M.J.
CC   GPRFLN|  TITLE     Cloning and expression of the chicken protein tyrosine phosphatase
CC   GPRFLN|            SH-PTP2
CC   GPRFLN|  JOURNAL   Gene 177 (1-2), 93-97 (1996)
CC   GPRFLN|  MEDLINE   97080506
CC   GPRFLN|  REMARK    erythroblast
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302464602|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    300       VNTIFKEY:269
FT   PROTEIN       1    300       phosphotyrosine phosphatase; PTP1D; PTP2c; SH-PTP2; SyP
FT                                VNTIFKEY:270
FT   DOMAIN       50    287       protein-tyrosine-phosphatase homology #label PTP
FT                                VNTIFKEY:1000; VNTINAME:PTP
FT   ACT_SITE    236    236       Cys (phosphocysteine intermediate)
FT                                VNTIFKEY:220; VNTINAME:Active_Site_1
FT   BINDING     242    242       substrate phosphate (Arg)
FT                                VNTIFKEY:1007; VNTINAME:Binding_1
SQ   SEQUENCE   300 AA;
     AEIESRVREL SKLAETTDKV KQGFWEEFET LQQQECKLLY SRKEGQRQEN KNKNRYKNIL        60
     PFDHTRVVLH DGDPNEPVSD YINANIIMPE FETKCNNSKP KKSYIATQGC LQNTVNDFWR       120
     MVFQENSRVI VMTTKEVERG KSKCVKYWPD EYSLKEYGVM RVRNVKESAA HDYTLRELKL       180
     SKVGQGNTER TVWQYHFRTW PDHGVPSDPG GVLDFLEEVH HKQESISDAG PVVVHCSAGI       240
     GRTGTFIVID ILIDIIREKG VDCDIDVPKT IQMVRSQRSG MVQTEAQYRF IYMAVQHYIE       300
//
ID   cypcaCD45_D1\(BAA92179) STANDARD;PRT;   276 AA.
AC   BAA92179;
DT   17-MAY-2003
DE   CD45 [Cyprinus carpio].
OS   Cyprinus carpio.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Cyprinus.
CC   GPRFLN|REFERENCE   1
CC   GPRFLN|  AUTHORS   Fujiki,K., Shin,D.H., Nakao,M. and Yano,T.
CC   GPRFLN|  TITLE     Molecular cloning of carp (Cyprinus carpio) leucocyte cell-derived
CC   GPRFLN|            chemotaxin 2, glia maturation factor beta, CD45 and lysozyme C by
CC   GPRFLN|            use of suppression subtractive hybridisation
CC   GPRFLN|  JOURNAL   Fish Shellfish Immunol. 10 (7), 643-650 (2000)
CC   GPRFLN|  MEDLINE   20531692
CC   GPRFLN|REFERENCE   2  (residues 1 to 1216)
CC   GPRFLN|  AUTHORS   Fujiki,K., Nakao,M., Shin,D. and Yano,T.
CC   GPRFLN|  TITLE     Direct Submission
CC   GPRFLN|  JOURNAL   Submitted (24-AUG-1999) Kazuhiro Fujiki, Kyushu University,
CC   GPRFLN|            Laboratory of Marine Biochemistry, Faculty of Agriculture; Hakozaki
CC   GPRFLN|            6-10-1, Higashi-ku, Fukuoka, Fukuoka 812-8581, Japan
CC   GPRFLN|            (E-mail:fujikik@agr.kyushu-u.ac.jp, Tel:81-92-642-2896,
CC   GPRFLN|            Fax:81-92-642-2894)
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302454614|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    276       VNTIFKEY:269
FT   PROTEIN       1    276       VNTIFKEY:270
SQ   SEQUENCE   276 AA;
     GGLVEAYKNK IADEGRLFMD EFQSIPRIFS NYTIKEAKKS ENQYKNRYVD ILPYDYNRVT        60
     LSTGGEDNYI NASFIEGYRE PKKYIAAQGP KDETVVDFWR MVWEQKSSII VMVTRCEEGN       120
     KTKCAQYWPS LDREAEIFEE FVVKIRSEEH CPDYVIRHLI LNNKREKGSE REVTHIQFIS       180
     WPDHGVPGDP SLLLKLRRRV NSFKNFFSGP VVVHCSAGVG RTGTYMSIDA MIESLEAEGR       240
     VDIYGFVAKL RRQRCLMVQV EAQYILIHTA LIEYNQ                                 276
//
ID   cypcaCD45_D2\(BAA92179) STANDARD;PRT;   302 AA.
AC   BAA92179;
DT   17-MAY-2003
DE   CD45 [Cyprinus carpio].
OS   Cyprinus carpio.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Cyprinus.
CC   GPRFLN|REFERENCE   1
CC   GPRFLN|  AUTHORS   Fujiki,K., Shin,D.H., Nakao,M. and Yano,T.
CC   GPRFLN|  TITLE     Molecular cloning of carp (Cyprinus carpio) leucocyte cell-derived
CC   GPRFLN|            chemotaxin 2, glia maturation factor beta, CD45 and lysozyme C by
CC   GPRFLN|            use of suppression subtractive hybridisation
CC   GPRFLN|  JOURNAL   Fish Shellfish Immunol. 10 (7), 643-650 (2000)
CC   GPRFLN|  MEDLINE   20531692
CC   GPRFLN|REFERENCE   2  (residues 1 to 1216)
CC   GPRFLN|  AUTHORS   Fujiki,K., Nakao,M., Shin,D. and Yano,T.
CC   GPRFLN|  TITLE     Direct Submission
CC   GPRFLN|  JOURNAL   Submitted (24-AUG-1999) Kazuhiro Fujiki, Kyushu University,
CC   GPRFLN|            Laboratory of Marine Biochemistry, Faculty of Agriculture; Hakozaki
CC   GPRFLN|            6-10-1, Higashi-ku, Fukuoka, Fukuoka 812-8581, Japan
CC   GPRFLN|            (E-mail:fujikik@agr.kyushu-u.ac.jp, Tel:81-92-642-2896,
CC   GPRFLN|            Fax:81-92-642-2894)
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302454709|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    302       VNTIFKEY:269
FT   PROTEIN       1    302       VNTIFKEY:270
SQ   SEQUENCE   302 AA;
     SEFHSVLNTL RQKNGSDPSL LEKEFQKLPK FKKWRTMNTG SSEDNKKKNR DSAVIPYDFN        60
     RVIFRLDIEG NQTSDPEDEE EYSSDEEEES NQYINASFID GYWCNKSLIA AQGPLQSTAE       120
     EFLLMLYQQQ TKTLVMLTDC QEDGKDYCFQ YWGDEKKTYG DMEIEVKKTE TFPTYVRRHL       180
     EIQSLKKKEV LKVDQYQFLK WRGRELPENA QELVEMASII RENGHYDNSK TNRNVPIVVH       240
     CNNGSSRTGI FCALWNLLDS AYTEKLVDVL QEVKNLRKLR QGMVETIEQY QFLYTALEGA       300
     FP                                                                      302
//
ID   fuCD45_D1\(CAB96211) STANDARD;PRT;   279 AA.
AC   CAB96211;
DT   17-MAY-2003
DE   CD45 [Takifugu rubripes].
OS   Takifugu rubripes.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; Acanthomorpha; Acanthopterygii; Percomorpha; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
CC   GPRFLN|REFERENCE   1
CC   GPRFLN|  AUTHORS   Diaz del Pozo,E.M., Beverley,P.C. and Timon,M.
CC   GPRFLN|  TITLE     Genomic structure and sequence of the leukocyte common antigen
CC   GPRFLN|            (CD45) from the pufferfish Fugu rubripes and comparison with its
CC   GPRFLN|            mammalian homologue
CC   GPRFLN|  JOURNAL   Unpublished
CC   GPRFLN|REFERENCE   2  (residues 1 to 1246)
CC   GPRFLN|  AUTHORS   Diaz del Pozo,E.M.
CC   GPRFLN|  TITLE     Direct Submission
CC   GPRFLN|  JOURNAL   Submitted (25-JUN-1999) Diaz del Pozo E.M., CD45 Group, The Edward
CC   GPRFLN|            Jenner Institute for Vaccine Research, High Street, Compton,
CC   GPRFLN|            Newbury, Berkshire, RG20 7NN, UNITED KINGDOM
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302488418|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    279       VNTIFKEY:269
FT   PROTEIN       1    279       VNTIFKEY:270
FT   CHAIN         1    279       VNTIFKEY:203; VNTINAME:Chain_1
SQ   SEQUENCE   279 AA;
     ETLLDAYKRK IADEGRLFLA EFQSIPRIFS KYTVKEAKKS HNVPKNRYVD ILPYDYNRVQ        60
     LTTGNGSAGC DYINASFIDG FKELKKYIAA QGPKEETVSN FWRMIWEQQT SIIVMVSRCE       120
     EGNRIKCAQY WPSEDRDTEI FEEFIVKLTS EDHYPDYIIR HLSLTNKKDK GSEREVTHIQ       180
     FMSWPDHGVP EEAQLLLKLR RRVNSFKNFF SGPIVVHCSA GVGRTGTYIG IDAMMESLEA       240
     EGRVDIYGYV VMLRRQRCLM VQVEAQYILI HQALLEHTQ                              279
//
ID   fuCD45_D2\(CAB96211) STANDARD;PRT;   301 AA.
AC   CAB96211;
DT   17-MAY-2003
DE   CD45 [Takifugu rubripes].
OS   Takifugu rubripes.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; Acanthomorpha; Acanthopterygii; Percomorpha; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
CC   GPRFLN|REFERENCE   1
CC   GPRFLN|  AUTHORS   Diaz del Pozo,E.M., Beverley,P.C. and Timon,M.
CC   GPRFLN|  TITLE     Genomic structure and sequence of the leukocyte common antigen
CC   GPRFLN|            (CD45) from the pufferfish Fugu rubripes and comparison with its
CC   GPRFLN|            mammalian homologue
CC   GPRFLN|  JOURNAL   Unpublished
CC   GPRFLN|REFERENCE   2  (residues 1 to 1246)
CC   GPRFLN|  AUTHORS   Diaz del Pozo,E.M.
CC   GPRFLN|  TITLE     Direct Submission
CC   GPRFLN|  JOURNAL   Submitted (25-JUN-1999) Diaz del Pozo E.M., CD45 Group, The Edward
CC   GPRFLN|            Jenner Institute for Vaccine Research, High Street, Compton,
CC   GPRFLN|            Newbury, Berkshire, RG20 7NN, UNITED KINGDOM
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302488507|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    301       VNTIFKEY:269
FT   PROTEIN       1    301       VNTIFKEY:270
FT   CHAIN         1    301       VNTIFKEY:203; VNTINAME:Chain_1
SQ   SEQUENCE   301 AA;
     QELHSTLNTL KQRSSDNEPT LLEDEFERLP NFKNWRTFNT GVTEENKKKN RTSSVIPYDY        60
     NRVLLKLDEE KSHESDPDPD DDYDTSSYDD IEDSAKYINA SLLSGYWGPH TFISAQTPLP       120
     DTVADFWSMI LQKRVSIVVM LSDCSQGDED CVYWGEDKKT VEDIEVETES TDNSPNFILR       180
     NMMIHHLKTD AHQQVKHFQF LKWGDKEVPE KPQDLADLIK EIKHRCGYTW PRSTPIIVHC       240
     NDGSSRSGAF CALWNLLDNA EKEKMVDVFQ VVKTLRKERQ GMCPSLEQYQ FLYDALEVVY       300
     P                                                                       301
//
ID   hBDP1_D1\(NP_055184)\PTPN18 STANDARD;PRT;   288 AA.
AC   NP_055184;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, non-receptor type 18; brain-derived phosphatase [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from X79568.1 and BI261717.1.
CC   On Jan 25, 2002 this sequence version replaced gi:7657484.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP contains a PEST motif, which
CC   often serves as a protein-protein interaction domain, and may be
CC   related to protein intracellular half-live. This gene was found to
CC   be expressed in brain, colon tissues, and several different
CC   tumor-derived cell lines. The bilogical function of this PTP has
CC   not yet been determined.
CC   GPRFLN|REFERENCE   1  (residues 1 to 460)
CC   GPRFLN|  AUTHORS   Kim,Y.W., Wang,H., Sures,I., Lammers,R., Martell,K.J. and
CC   GPRFLN|            Ullrich,A.
CC   GPRFLN|  TITLE     Characterization of the PEST family protein tyrosine phosphatase
CC   GPRFLN|            BDP1
CC   GPRFLN|  JOURNAL   Oncogene 13 (10), 2275-2279 (1996)
CC   GPRFLN|  MEDLINE   97108674
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    288       VNTIFKEY:269
FT   PROTEIN       1    288       brain-derived phosphatase
FT                                VNTIFKEY:270
FT   REGION       21    287       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   288 AA;
     DSARSFLERL EARGGREGAV LAGEFSDIQA CSAAWKADGV CSTVAGSRPE NVRKNRYKDV        60
     LPYDQTRVIL SLLQEEGHSD YINGNFIRGV DGSLAYIATQ GPLPHTLLDF WRLVWEFGVK       120
     VILMACREIE NGRKRCERYW AQEQEPLQTG LFCITLIKEK WLNEDIMLRT LKVTFQKESR       180
     SVYQLQYMSW PDRGVPSSPD HMLAMVEEAR RLQGSGPEPL CVHCSAGCGR TGVLCTVDYV       240
     RQLLLTQMIP PDFSLFDVVL KMRKQRPAAV QTEEQYRFLY HTVAQMFC                    288
//
ID   hCD45_D1\(NP_002829)\PTPRC STANDARD;PRT;   279 AA.
AC   NP_002829;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, C isoform 1 precursor; protein tyrosine phosphatase, receptor type, c polypeptide; leukocyte-common antigen; T200 glycoprotein; human homolog of severe combined immunodeficiency due to PTPRC deficiency; SCID due to PTPRC deficiency; CD45 antigen [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from Y00638.1 and Y00062.1.
CC   On Feb 8, 2002 this sequence version replaced gi:4506307.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP contains an extracellular
CC   domain, a single transmembrane segment and two tandem
CC   intracytoplasmic catalytic domains, and thus belongs to receptor
CC   type PTP. This gene is specifically expressed in hematopoietic
CC   cells. This PTP has been shown to be an essential regulator of T-
CC   and B-cell antigen receptor signaling. It functions through either
CC   direct interaction with components of the antigen receptor
CC   complexes, or by activating various Src family kinases required for
CC   the antigen receptor signaling. This PTP also suppresses JAK
CC   kinases, and thus functions as a regulator of cytokine receptor
CC   signaling. Four alternatively spliced transcripts variants of this
CC   gene, which encode distinct isoforms, have been reported.
CC   
CC   Transcript Variant: This variant (1) encodes the longest isoform
CC   (1).
CC   GPRFLN|REFERENCE   1  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Baldwin,T.A. and Ostergaard,H.L.
CC   GPRFLN|  TITLE     The protein-tyrosine phosphatase CD45 reaches the cell surface via
CC   GPRFLN|            golgi-dependent and -independent pathways
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (52), 50333-50340 (2002)
CC   GPRFLN|  MEDLINE   22384317
CC   GPRFLN|  REMARK    GeneRIF: reaches the cell surface via Golgi-dependent and
CC   GPRFLN|            -independent pathways
CC   GPRFLN|REFERENCE   2  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Harashima,A., Suzuki,M., Okochi,A., Yamamoto,M., Matsuo,Y.,
CC   GPRFLN|            Motoda,R., Yoshioka,T. and Orita,K.
CC   GPRFLN|  TITLE     CD45 tyrosine phosphatase inhibits erythroid differentiation of
CC   GPRFLN|            umbilical cord blood CD34+ cells associated with selective
CC   GPRFLN|            inactivation of Lyn
CC   GPRFLN|  JOURNAL   Blood 100 (13), 4440-4445 (2002)
CC   GPRFLN|  MEDLINE   22340750
CC   GPRFLN|  REMARK    GeneRIF: CD45 may play a pivotal role in erythropoiesis. CD45
CC   GPRFLN|            tyrosine phosphatase inhibits erythroid differentiation of
CC   GPRFLN|            umbilical cord blood CD34+ cells associated with selective
CC   GPRFLN|            inactivation of Lyn.
CC   GPRFLN|REFERENCE   3  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J.
CC   GPRFLN|  TITLE     Intra- and intermolecular interactions between intracellular
CC   GPRFLN|            domains of receptor protein-tyrosine phosphatases
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (49), 47263-47269 (2002)
CC   GPRFLN|  MEDLINE   22344739
CC   GPRFLN|  REMARK    GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are
CC   GPRFLN|            a common but specific mechanism that is likely to be regulated-
CC   GPRFLN|            domain2s and the wedge structures are crucial determinants of
CC   GPRFLN|            binding specificity, thus regulating cross-talk between RPTPs
CC   GPRFLN|REFERENCE   4  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Pradhan,D. and Morrow,J.
CC   GPRFLN|  TITLE     The spectrin-ankyrin skeleton controls CD45 surface display and
CC   GPRFLN|            interleukin-2 production
CC   GPRFLN|  JOURNAL   Immunity 17 (3), 303-315 (2002)
CC   GPRFLN|  MEDLINE   22241694
CC   GPRFLN|  REMARK    GeneRIF: The spectrin-ankyrin skeleton controls CD45 surface
CC   GPRFLN|            display and interleukin-2 production.
CC   GPRFLN|REFERENCE   5  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Ballerini,C., Rosati,E., Salvetti,M., Ristori,G., Cannoni,S.,
CC   GPRFLN|            Biagioli,T., Massacesi,L., Sorbi,S. and Vergelli,M.
CC   GPRFLN|  TITLE     Protein tyrosine phosphatase receptor-type C exon 4 gene mutation
CC   GPRFLN|            distribution in an Italian multiple sclerosis population
CC   GPRFLN|  JOURNAL   Neurosci. Lett. 328 (3), 325-327 (2002)
CC   GPRFLN|  MEDLINE   22142931
CC   GPRFLN|  REMARK    GeneRIF: Role of the C-->G mutation in position 77 of exon 4 of the
CC   GPRFLN|            protein tyrosine phosphatase receptor-type C (PTPRC) gene, coding
CC   GPRFLN|            for the CD45 molecule, for the development of multiple sclerosis
CC   GPRFLN|            (MS) in Italy.
CC   GPRFLN|REFERENCE   6  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Yamada,T., Zhu,D., Saxon,A. and Zhang,K.
CC   GPRFLN|  TITLE     CD45 controls interleukin-4-mediated IgE class switch recombination
CC   GPRFLN|            in human B cells through its function as a Janus kinase phosphatase
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (32), 28830-28835 (2002)
CC   GPRFLN|  MEDLINE   22151051
CC   GPRFLN|  REMARK    GeneRIF: CD45 controls interleukin-4-mediated IgE class switch
CC   GPRFLN|            recombination in human B cells
CC   GPRFLN|REFERENCE   7  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Yu,C., Yu,H.S., Sun,K.H., Hsieh,S.C. and Tsai,C.Y.
CC   GPRFLN|  TITLE     Anti-CD45 isoform antibodies enhance phagocytosis and gene
CC   GPRFLN|            expression of IL-8 and TNF-alpha in human neutrophils by
CC   GPRFLN|            differential suppression on protein tyrosine phosphorylation and
CC   GPRFLN|            p56lck tyrosine kinase
CC   GPRFLN|  JOURNAL   Clin. Exp. Immunol. 129 (1), 78-85 (2002)
CC   GPRFLN|  MEDLINE   22095000
CC   GPRFLN|  REMARK    GeneRIF: Biological functions of membrane expressed CD45 isoforms
CC   GPRFLN|            on PMNs were studied. Cross-linking of CD45 isoforms by specific
CC   GPRFLN|            MAbs stimulated different PMN activities by differential
CC   GPRFLN|            suppression on protein tyrosine phosphorylation and p56lck.
CC   GPRFLN|REFERENCE   8  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Jacobsen,M., Hoffmann,S., Cepok,S., Stei,S., Ziegler,A., Sommer,N.
CC   GPRFLN|            and Hemmer,B.
CC   GPRFLN|  TITLE     A novel mutation in PTPRC interferes with splicing and alters the
CC   GPRFLN|            structure of the human CD45 molecule
CC   GPRFLN|  JOURNAL   Immunogenetics 54 (3), 158-163 (2002)
CC   GPRFLN|  MEDLINE   22067726
CC   GPRFLN|  REMARK    GeneRIF: a mutation in PTPRC interferes with splicing and alters
CC   GPRFLN|            the structure of the CD45 molecule
CC   GPRFLN|REFERENCE   9  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Tchilian,E.Z. and Beverley,P.C.
CC   GPRFLN|  TITLE     CD45 in memory and disease
CC   GPRFLN|  JOURNAL   Arch. Immunol. Ther. Exp. (Warsz.) 50 (2), 85-93 (2002)
CC   GPRFLN|  MEDLINE   22017393
CC   GPRFLN|  REMARK    GeneRIF: Role of high and low molecular weight isoforms of CD45 in
CC   GPRFLN|            the function of na##ve and memory T lymphocytes. Review.
CC   GPRFLN|REFERENCE   10 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Fajka-Boja,R., Szemes,M., Ion,G., Legradi,A., Caron,M. and
CC   GPRFLN|            Monostori,E.
CC   GPRFLN|  TITLE     Receptor tyrosine phosphatase, CD45 binds galectin-1 but does not
CC   GPRFLN|            mediate its apoptotic signal in T cell lines
CC   GPRFLN|  JOURNAL   Immunol. Lett. 82 (1-2), 149-154 (2002)
CC   GPRFLN|  MEDLINE   22003829
CC   GPRFLN|  REMARK    GeneRIF: Receptor tyrosine phosphatase, CD45 binds galectin-1 but
CC   GPRFLN|            does not mediate its apoptotic signal in Jurkat cells
CC   GPRFLN|REFERENCE   11 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Fukuhara,K., Okumura,M., Shiono,H., Inoue,M., Kadota,Y., Miyoshi,S.
CC   GPRFLN|            and Matsuda,H.
CC   GPRFLN|  TITLE     A study on CD45 isoform expression during T-cell development and
CC   GPRFLN|            selection events in the human thymus
CC   GPRFLN|  JOURNAL   Hum. Immunol. 63 (5), 394-404 (2002)
CC   GPRFLN|  MEDLINE   21972715
CC   GPRFLN|  REMARK    GeneRIF: analysis of CD45 isoform expression during T-cell
CC   GPRFLN|            development and selection in the human thymus
CC   GPRFLN|REFERENCE   12 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Wu,L., Fu,J. and Shen,S.H.
CC   GPRFLN|  TITLE     SKAP55 coupled with CD45 positively regulates T-cell
CC   GPRFLN|            receptor-mediated gene transcription
CC   GPRFLN|  JOURNAL   Mol. Cell. Biol. 22 (8), 2673-2686 (2002)
CC   GPRFLN|  MEDLINE   21907230
CC   GPRFLN|  REMARK    GeneRIF: SKAP55 coupled with CD45 positively regulates T-cell
CC   GPRFLN|            receptor-mediated gene transcription.
CC   GPRFLN|REFERENCE   13 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Ishikawa,H., Tsuyama,N., Abroun,S., Liu,S., Li,F.J., Taniguchi,O.
CC   GPRFLN|            and Kawano,M.M.
CC   GPRFLN|  TITLE     Requirements of src family kinase activity associated with CD45 for
CC   GPRFLN|            myeloma cell proliferation by interleukin-6
CC   GPRFLN|  JOURNAL   Blood 99 (6), 2172-2178 (2002)
CC   GPRFLN|  MEDLINE   21866149
CC   GPRFLN|  REMARK    GeneRIF: Requirements of src family kinase activity associated with
CC   GPRFLN|            CD45 for myeloma cell proliferation by interleukin-6
CC   GPRFLN|REFERENCE   14 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Tchilian,E.Z., Dawes,R., Ramaley,P.A., Whitworth,J.A.,
CC   GPRFLN|            Yuldasheva,N., Wells,R.S., Watera,C., French,N., Gilks,C.F.,
CC   GPRFLN|            Kunachiwa,W., Ruzibakiev,R., Leetrakool,N., Carrington,C.V.,
CC   GPRFLN|            Ramdath,D.D., Gotch,F., Stephens,H.A., Hill,A.V. and Beverley,P.C.
CC   GPRFLN|  TITLE     A CD45 polymorphism associated with abnormal splicing is absent in
CC   GPRFLN|            African populations
CC   GPRFLN|  JOURNAL   Immunogenetics 53 (10-11), 980-983 (2002)
CC   GPRFLN|  MEDLINE   21850514
CC   GPRFLN|  REMARK    GeneRIF: we examined the frequency of the C77G allele in African
CC   GPRFLN|            and Asian populations from countries with high or low prevalence of
CC   GPRFLN|            HIV infection; Here we report that the variant CD45 C77G allele is
CC   GPRFLN|            absent in African populations
CC   GPRFLN|REFERENCE   15 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Wood,J.P., Bieda,K., Segni,M., Herwig,J., Krause,M., Usadel,K.H.
CC   GPRFLN|            and Badenhoop,K.
CC   GPRFLN|  TITLE     CD45 exon 4 point mutation does not confer susceptibility to type 1
CC   GPRFLN|            diabetes mellitus or Graves' disease
CC   GPRFLN|  JOURNAL   Eur. J. Immunogenet. 29 (1), 73-74 (2002)
CC   GPRFLN|  MEDLINE   21830605
CC   GPRFLN|  REMARK    GeneRIF: CD45 variant (C77G, exon 4) does not confer susceptibility
CC   GPRFLN|            to either IDDM or Graves' disease
CC   GPRFLN|REFERENCE   16 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Moro,H., Iwai,K., Mori,N., Watanabe,M., Fukushi,M., Oie,M.,
CC   GPRFLN|            Arai,M., Tanaka,Y., Miyawaki,T., Gejyo,F., Arakawa,M. and Fujii,M.
CC   GPRFLN|  TITLE     Interleukin-2-dependent but not independent T-cell lines infected
CC   GPRFLN|            with human T-cell leukemia virus type 1 selectively express CD45RO,
CC   GPRFLN|            a marker for persistent infection in vivo
CC   GPRFLN|  JOURNAL   Virus Genes 23 (3), 263-271 (2001)
CC   GPRFLN|  MEDLINE   21636965
CC   GPRFLN|  REMARK    GeneRIF: role of CD45RO in the persistent HTLV-1 infection in vivo
CC   GPRFLN|REFERENCE   17 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Irie-Sasaki,J., Sasaki,T., Matsumoto,W., Opavsky,A., Cheng,M.,
CC   GPRFLN|            Welstead,G., Griffiths,E., Krawczyk,C., Richardson,C.D., Aitken,K.,
CC   GPRFLN|            Iscove,N., Koretzky,G., Johnson,P., Liu,P., Rothstein,D.M. and
CC   GPRFLN|            Penninger,J.M.
CC   GPRFLN|  TITLE     CD45 is a JAK phosphatase and negatively regulates cytokine
CC   GPRFLN|            receptor signalling
CC   GPRFLN|  JOURNAL   Nature 409 (6818), 349-354 (2001)
CC   GPRFLN|  MEDLINE   21069057
CC   GPRFLN|REFERENCE   18 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Goff,L.K., van Soest,S., Timon,M., Tchilian,E. and Beverley,P.C.
CC   GPRFLN|  TITLE     Protein tyrosine phosphatase receptor type C polypeptide (PTPRC) on
CC   GPRFLN|            human chromosome band 1q31-->q32 localizes with marker D1S413(1) on
CC   GPRFLN|            a 610-kb yeast artificial chromosome
CC   GPRFLN|  JOURNAL   Cytogenet. Cell Genet. 87 (3-4), 223-224 (1999)
CC   GPRFLN|  MEDLINE   20169194
CC   GPRFLN|REFERENCE   19 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Petricoin,E.F. III, Ito,S., Williams,B.L., Audet,S., Stancato,L.F.,
CC   GPRFLN|            Gamero,A., Clouse,K., Grimley,P., Weiss,A., Beeler,J.,
CC   GPRFLN|            Finbloom,D.S., Shores,E.W., Abraham,R. and Larner,A.C.
CC   GPRFLN|  TITLE     Antiproliferative action of interferon-alpha requires components of
CC   GPRFLN|            T-cell-receptor signalling
CC   GPRFLN|  JOURNAL   Nature 390 (6660), 629-632 (1997)
CC   GPRFLN|  MEDLINE   98065953
CC   GPRFLN|REFERENCE   20 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Kaplan,R., Morse,B., Huebner,K., Croce,C., Howk,R., Ravera,M.,
CC   GPRFLN|            Ricca,G., Jaye,M. and Schlessinger,J.
CC   GPRFLN|  TITLE     Cloning of three human tyrosine phosphatases reveals a multigene
CC   GPRFLN|            family of receptor-linked protein-tyrosine-phosphatases expressed
CC   GPRFLN|            in brain
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (18), 7000-7004 (1990)
CC   GPRFLN|  MEDLINE   90384936
CC   GPRFLN|REFERENCE   21 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Schraven,B., Samstag,Y., Altevogt,P. and Meuer,S.C.
CC   GPRFLN|  TITLE     Association of CD2 and CD45 on human T lymphocytes
CC   GPRFLN|  JOURNAL   Nature 345 (6270), 71-74 (1990)
CC   GPRFLN|  MEDLINE   90231464
CC   GPRFLN|REFERENCE   22 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Pingel,J.T. and Thomas,M.L.
CC   GPRFLN|  TITLE     Evidence that the leukocyte-common antigen is required for
CC   GPRFLN|            antigen-induced T lymphocyte proliferation
CC   GPRFLN|  JOURNAL   Cell 58 (6), 1055-1065 (1989)
CC   GPRFLN|  MEDLINE   89376557
CC   GPRFLN|REFERENCE   23 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Charbonneau,H., Tonks,N.K., Walsh,K.A. and Fischer,E.H.
CC   GPRFLN|  TITLE     The leukocyte common antigen (CD45): a putative receptor-linked
CC   GPRFLN|            protein tyrosine phosphatase
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 85 (19), 7182-7186 (1988)
CC   GPRFLN|  MEDLINE   89017162
CC   GPRFLN|REFERENCE   24 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Streuli,M., Hall,L.R., Saga,Y., Schlossman,S.F. and Saito,H.
CC   GPRFLN|  TITLE     Differential usage of three exons generates at least five different
CC   GPRFLN|            mRNAs encoding human leukocyte common antigens
CC   GPRFLN|  JOURNAL   J. Exp. Med. 166 (5), 1548-1566 (1987)
CC   GPRFLN|  MEDLINE   88061067
CC   GPRFLN|REFERENCE   25 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Ralph,S.J., Thomas,M.L., Morton,C.C. and Trowbridge,I.S.
CC   GPRFLN|  TITLE     Structural variants of human T200 glycoprotein (leukocyte-common
CC   GPRFLN|            antigen)
CC   GPRFLN|  JOURNAL   EMBO J. 6 (5), 1251-1257 (1987)
CC   GPRFLN|  MEDLINE   87275816
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    279       VNTIFKEY:269
FT   PROTEIN       1    279       protein tyrosine phosphatase, receptor type, c polypeptide; leukocyte-common antigen; T200 glycoprotein; human homolog of severe combined immunodeficiency due to PTPRC deficiency; SCID due to PTPRC deficiency; CD45 antigen
FT                                VNTIFKEY:270
FT   CHAIN         1    279       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       17    277       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_2
SQ   SEQUENCE   279 AA;
     DILLETYKRK IADEGRLFLA EFQSIPRVFS KFPIKEARKP FNQNKNRYVD ILPYDYNRVE        60
     LSEINGDAGS NYINASYIDG FKEPRKYIAA QGPRDETVDD FWRMIWEQKA TVIVMVTRCE       120
     EGNRNKCAEY WPSMEEGTRA FGDVVVKINQ HKRCPDYIIQ KLNIVNKKEK ATGREVTHIQ       180
     FTSWPDHGVP EDPHLLLKLR RRVNAFSNFF SGPIVVHCSA GVGRTGTYIG IDAMLEGLEA       240
     ENKVDVYGYV VKLRRQRCLM VQVEAQYILI HQALVEYNQ                              279
//
ID   hCD45_D2\(NP_002829)\PTPRC STANDARD;PRT;   308 AA.
AC   NP_002829;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, C isoform 1 precursor; protein tyrosine phosphatase, receptor type, c polypeptide; leukocyte-common antigen; T200 glycoprotein; human homolog of severe combined immunodeficiency due to PTPRC deficiency; SCID due to PTPRC deficiency; CD45 antigen [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from Y00638.1 and Y00062.1.
CC   On Feb 8, 2002 this sequence version replaced gi:4506307.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP contains an extracellular
CC   domain, a single transmembrane segment and two tandem
CC   intracytoplasmic catalytic domains, and thus belongs to receptor
CC   type PTP. This gene is specifically expressed in hematopoietic
CC   cells. This PTP has been shown to be an essential regulator of T-
CC   and B-cell antigen receptor signaling. It functions through either
CC   direct interaction with components of the antigen receptor
CC   complexes, or by activating various Src family kinases required for
CC   the antigen receptor signaling. This PTP also suppresses JAK
CC   kinases, and thus functions as a regulator of cytokine receptor
CC   signaling. Four alternatively spliced transcripts variants of this
CC   gene, which encode distinct isoforms, have been reported.
CC   
CC   Transcript Variant: This variant (1) encodes the longest isoform
CC   (1).
CC   GPRFLN|REFERENCE   1  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Baldwin,T.A. and Ostergaard,H.L.
CC   GPRFLN|  TITLE     The protein-tyrosine phosphatase CD45 reaches the cell surface via
CC   GPRFLN|            golgi-dependent and -independent pathways
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (52), 50333-50340 (2002)
CC   GPRFLN|  MEDLINE   22384317
CC   GPRFLN|  REMARK    GeneRIF: reaches the cell surface via Golgi-dependent and
CC   GPRFLN|            -independent pathways
CC   GPRFLN|REFERENCE   2  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Harashima,A., Suzuki,M., Okochi,A., Yamamoto,M., Matsuo,Y.,
CC   GPRFLN|            Motoda,R., Yoshioka,T. and Orita,K.
CC   GPRFLN|  TITLE     CD45 tyrosine phosphatase inhibits erythroid differentiation of
CC   GPRFLN|            umbilical cord blood CD34+ cells associated with selective
CC   GPRFLN|            inactivation of Lyn
CC   GPRFLN|  JOURNAL   Blood 100 (13), 4440-4445 (2002)
CC   GPRFLN|  MEDLINE   22340750
CC   GPRFLN|  REMARK    GeneRIF: CD45 may play a pivotal role in erythropoiesis. CD45
CC   GPRFLN|            tyrosine phosphatase inhibits erythroid differentiation of
CC   GPRFLN|            umbilical cord blood CD34+ cells associated with selective
CC   GPRFLN|            inactivation of Lyn.
CC   GPRFLN|REFERENCE   3  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J.
CC   GPRFLN|  TITLE     Intra- and intermolecular interactions between intracellular
CC   GPRFLN|            domains of receptor protein-tyrosine phosphatases
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (49), 47263-47269 (2002)
CC   GPRFLN|  MEDLINE   22344739
CC   GPRFLN|  REMARK    GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are
CC   GPRFLN|            a common but specific mechanism that is likely to be regulated-
CC   GPRFLN|            domain2s and the wedge structures are crucial determinants of
CC   GPRFLN|            binding specificity, thus regulating cross-talk between RPTPs
CC   GPRFLN|REFERENCE   4  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Pradhan,D. and Morrow,J.
CC   GPRFLN|  TITLE     The spectrin-ankyrin skeleton controls CD45 surface display and
CC   GPRFLN|            interleukin-2 production
CC   GPRFLN|  JOURNAL   Immunity 17 (3), 303-315 (2002)
CC   GPRFLN|  MEDLINE   22241694
CC   GPRFLN|  REMARK    GeneRIF: The spectrin-ankyrin skeleton controls CD45 surface
CC   GPRFLN|            display and interleukin-2 production.
CC   GPRFLN|REFERENCE   5  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Ballerini,C., Rosati,E., Salvetti,M., Ristori,G., Cannoni,S.,
CC   GPRFLN|            Biagioli,T., Massacesi,L., Sorbi,S. and Vergelli,M.
CC   GPRFLN|  TITLE     Protein tyrosine phosphatase receptor-type C exon 4 gene mutation
CC   GPRFLN|            distribution in an Italian multiple sclerosis population
CC   GPRFLN|  JOURNAL   Neurosci. Lett. 328 (3), 325-327 (2002)
CC   GPRFLN|  MEDLINE   22142931
CC   GPRFLN|  REMARK    GeneRIF: Role of the C-->G mutation in position 77 of exon 4 of the
CC   GPRFLN|            protein tyrosine phosphatase receptor-type C (PTPRC) gene, coding
CC   GPRFLN|            for the CD45 molecule, for the development of multiple sclerosis
CC   GPRFLN|            (MS) in Italy.
CC   GPRFLN|REFERENCE   6  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Yamada,T., Zhu,D., Saxon,A. and Zhang,K.
CC   GPRFLN|  TITLE     CD45 controls interleukin-4-mediated IgE class switch recombination
CC   GPRFLN|            in human B cells through its function as a Janus kinase phosphatase
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (32), 28830-28835 (2002)
CC   GPRFLN|  MEDLINE   22151051
CC   GPRFLN|  REMARK    GeneRIF: CD45 controls interleukin-4-mediated IgE class switch
CC   GPRFLN|            recombination in human B cells
CC   GPRFLN|REFERENCE   7  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Yu,C., Yu,H.S., Sun,K.H., Hsieh,S.C. and Tsai,C.Y.
CC   GPRFLN|  TITLE     Anti-CD45 isoform antibodies enhance phagocytosis and gene
CC   GPRFLN|            expression of IL-8 and TNF-alpha in human neutrophils by
CC   GPRFLN|            differential suppression on protein tyrosine phosphorylation and
CC   GPRFLN|            p56lck tyrosine kinase
CC   GPRFLN|  JOURNAL   Clin. Exp. Immunol. 129 (1), 78-85 (2002)
CC   GPRFLN|  MEDLINE   22095000
CC   GPRFLN|  REMARK    GeneRIF: Biological functions of membrane expressed CD45 isoforms
CC   GPRFLN|            on PMNs were studied. Cross-linking of CD45 isoforms by specific
CC   GPRFLN|            MAbs stimulated different PMN activities by differential
CC   GPRFLN|            suppression on protein tyrosine phosphorylation and p56lck.
CC   GPRFLN|REFERENCE   8  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Jacobsen,M., Hoffmann,S., Cepok,S., Stei,S., Ziegler,A., Sommer,N.
CC   GPRFLN|            and Hemmer,B.
CC   GPRFLN|  TITLE     A novel mutation in PTPRC interferes with splicing and alters the
CC   GPRFLN|            structure of the human CD45 molecule
CC   GPRFLN|  JOURNAL   Immunogenetics 54 (3), 158-163 (2002)
CC   GPRFLN|  MEDLINE   22067726
CC   GPRFLN|  REMARK    GeneRIF: a mutation in PTPRC interferes with splicing and alters
CC   GPRFLN|            the structure of the CD45 molecule
CC   GPRFLN|REFERENCE   9  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Tchilian,E.Z. and Beverley,P.C.
CC   GPRFLN|  TITLE     CD45 in memory and disease
CC   GPRFLN|  JOURNAL   Arch. Immunol. Ther. Exp. (Warsz.) 50 (2), 85-93 (2002)
CC   GPRFLN|  MEDLINE   22017393
CC   GPRFLN|  REMARK    GeneRIF: Role of high and low molecular weight isoforms of CD45 in
CC   GPRFLN|            the function of na##ve and memory T lymphocytes. Review.
CC   GPRFLN|REFERENCE   10 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Fajka-Boja,R., Szemes,M., Ion,G., Legradi,A., Caron,M. and
CC   GPRFLN|            Monostori,E.
CC   GPRFLN|  TITLE     Receptor tyrosine phosphatase, CD45 binds galectin-1 but does not
CC   GPRFLN|            mediate its apoptotic signal in T cell lines
CC   GPRFLN|  JOURNAL   Immunol. Lett. 82 (1-2), 149-154 (2002)
CC   GPRFLN|  MEDLINE   22003829
CC   GPRFLN|  REMARK    GeneRIF: Receptor tyrosine phosphatase, CD45 binds galectin-1 but
CC   GPRFLN|            does not mediate its apoptotic signal in Jurkat cells
CC   GPRFLN|REFERENCE   11 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Fukuhara,K., Okumura,M., Shiono,H., Inoue,M., Kadota,Y., Miyoshi,S.
CC   GPRFLN|            and Matsuda,H.
CC   GPRFLN|  TITLE     A study on CD45 isoform expression during T-cell development and
CC   GPRFLN|            selection events in the human thymus
CC   GPRFLN|  JOURNAL   Hum. Immunol. 63 (5), 394-404 (2002)
CC   GPRFLN|  MEDLINE   21972715
CC   GPRFLN|  REMARK    GeneRIF: analysis of CD45 isoform expression during T-cell
CC   GPRFLN|            development and selection in the human thymus
CC   GPRFLN|REFERENCE   12 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Wu,L., Fu,J. and Shen,S.H.
CC   GPRFLN|  TITLE     SKAP55 coupled with CD45 positively regulates T-cell
CC   GPRFLN|            receptor-mediated gene transcription
CC   GPRFLN|  JOURNAL   Mol. Cell. Biol. 22 (8), 2673-2686 (2002)
CC   GPRFLN|  MEDLINE   21907230
CC   GPRFLN|  REMARK    GeneRIF: SKAP55 coupled with CD45 positively regulates T-cell
CC   GPRFLN|            receptor-mediated gene transcription.
CC   GPRFLN|REFERENCE   13 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Ishikawa,H., Tsuyama,N., Abroun,S., Liu,S., Li,F.J., Taniguchi,O.
CC   GPRFLN|            and Kawano,M.M.
CC   GPRFLN|  TITLE     Requirements of src family kinase activity associated with CD45 for
CC   GPRFLN|            myeloma cell proliferation by interleukin-6
CC   GPRFLN|  JOURNAL   Blood 99 (6), 2172-2178 (2002)
CC   GPRFLN|  MEDLINE   21866149
CC   GPRFLN|  REMARK    GeneRIF: Requirements of src family kinase activity associated with
CC   GPRFLN|            CD45 for myeloma cell proliferation by interleukin-6
CC   GPRFLN|REFERENCE   14 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Tchilian,E.Z., Dawes,R., Ramaley,P.A., Whitworth,J.A.,
CC   GPRFLN|            Yuldasheva,N., Wells,R.S., Watera,C., French,N., Gilks,C.F.,
CC   GPRFLN|            Kunachiwa,W., Ruzibakiev,R., Leetrakool,N., Carrington,C.V.,
CC   GPRFLN|            Ramdath,D.D., Gotch,F., Stephens,H.A., Hill,A.V. and Beverley,P.C.
CC   GPRFLN|  TITLE     A CD45 polymorphism associated with abnormal splicing is absent in
CC   GPRFLN|            African populations
CC   GPRFLN|  JOURNAL   Immunogenetics 53 (10-11), 980-983 (2002)
CC   GPRFLN|  MEDLINE   21850514
CC   GPRFLN|  REMARK    GeneRIF: we examined the frequency of the C77G allele in African
CC   GPRFLN|            and Asian populations from countries with high or low prevalence of
CC   GPRFLN|            HIV infection; Here we report that the variant CD45 C77G allele is
CC   GPRFLN|            absent in African populations
CC   GPRFLN|REFERENCE   15 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Wood,J.P., Bieda,K., Segni,M., Herwig,J., Krause,M., Usadel,K.H.
CC   GPRFLN|            and Badenhoop,K.
CC   GPRFLN|  TITLE     CD45 exon 4 point mutation does not confer susceptibility to type 1
CC   GPRFLN|            diabetes mellitus or Graves' disease
CC   GPRFLN|  JOURNAL   Eur. J. Immunogenet. 29 (1), 73-74 (2002)
CC   GPRFLN|  MEDLINE   21830605
CC   GPRFLN|  REMARK    GeneRIF: CD45 variant (C77G, exon 4) does not confer susceptibility
CC   GPRFLN|            to either IDDM or Graves' disease
CC   GPRFLN|REFERENCE   16 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Moro,H., Iwai,K., Mori,N., Watanabe,M., Fukushi,M., Oie,M.,
CC   GPRFLN|            Arai,M., Tanaka,Y., Miyawaki,T., Gejyo,F., Arakawa,M. and Fujii,M.
CC   GPRFLN|  TITLE     Interleukin-2-dependent but not independent T-cell lines infected
CC   GPRFLN|            with human T-cell leukemia virus type 1 selectively express CD45RO,
CC   GPRFLN|            a marker for persistent infection in vivo
CC   GPRFLN|  JOURNAL   Virus Genes 23 (3), 263-271 (2001)
CC   GPRFLN|  MEDLINE   21636965
CC   GPRFLN|  REMARK    GeneRIF: role of CD45RO in the persistent HTLV-1 infection in vivo
CC   GPRFLN|REFERENCE   17 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Irie-Sasaki,J., Sasaki,T., Matsumoto,W., Opavsky,A., Cheng,M.,
CC   GPRFLN|            Welstead,G., Griffiths,E., Krawczyk,C., Richardson,C.D., Aitken,K.,
CC   GPRFLN|            Iscove,N., Koretzky,G., Johnson,P., Liu,P., Rothstein,D.M. and
CC   GPRFLN|            Penninger,J.M.
CC   GPRFLN|  TITLE     CD45 is a JAK phosphatase and negatively regulates cytokine
CC   GPRFLN|            receptor signalling
CC   GPRFLN|  JOURNAL   Nature 409 (6818), 349-354 (2001)
CC   GPRFLN|  MEDLINE   21069057
CC   GPRFLN|REFERENCE   18 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Goff,L.K., van Soest,S., Timon,M., Tchilian,E. and Beverley,P.C.
CC   GPRFLN|  TITLE     Protein tyrosine phosphatase receptor type C polypeptide (PTPRC) on
CC   GPRFLN|            human chromosome band 1q31-->q32 localizes with marker D1S413(1) on
CC   GPRFLN|            a 610-kb yeast artificial chromosome
CC   GPRFLN|  JOURNAL   Cytogenet. Cell Genet. 87 (3-4), 223-224 (1999)
CC   GPRFLN|  MEDLINE   20169194
CC   GPRFLN|REFERENCE   19 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Petricoin,E.F. III, Ito,S., Williams,B.L., Audet,S., Stancato,L.F.,
CC   GPRFLN|            Gamero,A., Clouse,K., Grimley,P., Weiss,A., Beeler,J.,
CC   GPRFLN|            Finbloom,D.S., Shores,E.W., Abraham,R. and Larner,A.C.
CC   GPRFLN|  TITLE     Antiproliferative action of interferon-alpha requires components of
CC   GPRFLN|            T-cell-receptor signalling
CC   GPRFLN|  JOURNAL   Nature 390 (6660), 629-632 (1997)
CC   GPRFLN|  MEDLINE   98065953
CC   GPRFLN|REFERENCE   20 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Kaplan,R., Morse,B., Huebner,K., Croce,C., Howk,R., Ravera,M.,
CC   GPRFLN|            Ricca,G., Jaye,M. and Schlessinger,J.
CC   GPRFLN|  TITLE     Cloning of three human tyrosine phosphatases reveals a multigene
CC   GPRFLN|            family of receptor-linked protein-tyrosine-phosphatases expressed
CC   GPRFLN|            in brain
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (18), 7000-7004 (1990)
CC   GPRFLN|  MEDLINE   90384936
CC   GPRFLN|REFERENCE   21 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Schraven,B., Samstag,Y., Altevogt,P. and Meuer,S.C.
CC   GPRFLN|  TITLE     Association of CD2 and CD45 on human T lymphocytes
CC   GPRFLN|  JOURNAL   Nature 345 (6270), 71-74 (1990)
CC   GPRFLN|  MEDLINE   90231464
CC   GPRFLN|REFERENCE   22 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Pingel,J.T. and Thomas,M.L.
CC   GPRFLN|  TITLE     Evidence that the leukocyte-common antigen is required for
CC   GPRFLN|            antigen-induced T lymphocyte proliferation
CC   GPRFLN|  JOURNAL   Cell 58 (6), 1055-1065 (1989)
CC   GPRFLN|  MEDLINE   89376557
CC   GPRFLN|REFERENCE   23 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Charbonneau,H., Tonks,N.K., Walsh,K.A. and Fischer,E.H.
CC   GPRFLN|  TITLE     The leukocyte common antigen (CD45): a putative receptor-linked
CC   GPRFLN|            protein tyrosine phosphatase
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 85 (19), 7182-7186 (1988)
CC   GPRFLN|  MEDLINE   89017162
CC   GPRFLN|REFERENCE   24 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Streuli,M., Hall,L.R., Saga,Y., Schlossman,S.F. and Saito,H.
CC   GPRFLN|  TITLE     Differential usage of three exons generates at least five different
CC   GPRFLN|            mRNAs encoding human leukocyte common antigens
CC   GPRFLN|  JOURNAL   J. Exp. Med. 166 (5), 1548-1566 (1987)
CC   GPRFLN|  MEDLINE   88061067
CC   GPRFLN|REFERENCE   25 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Ralph,S.J., Thomas,M.L., Morton,C.C. and Trowbridge,I.S.
CC   GPRFLN|  TITLE     Structural variants of human T200 glycoprotein (leukocyte-common
CC   GPRFLN|            antigen)
CC   GPRFLN|  JOURNAL   EMBO J. 6 (5), 1251-1257 (1987)
CC   GPRFLN|  MEDLINE   87275816
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    308       VNTIFKEY:269
FT   PROTEIN       1    308       protein tyrosine phosphatase, receptor type, c polypeptide; leukocyte-common antigen; T200 glycoprotein; human homolog of severe combined immunodeficiency due to PTPRC deficiency; SCID due to PTPRC deficiency; CD45 antigen
FT                                VNTIFKEY:270
FT   CHAIN         1    308       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       22    307       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_3
SQ   SEQUENCE   308 AA;
     SELHPYLHNM KKRDPPSEPS PLEAEFQRLP SYRSWRTQHI GNQEENKSKN RNSNVIPYDY        60
     NRVPLKHELE MSKESEHDSD ESSDDDSDSE EPSKYINASF IMSYWKPEVM IAAQGPLKET       120
     IGDFWQMIFQ RKVKVIVMLT ELKHGDQEIC AQYWGEGKQT YGDIEVDLKD TDKSSTYTLR       180
     VFELRHSKRK DSRTVYQYQY TNWSVEQLPA EPKELISMIQ VVKQKLPQKN SSEGNKHHKS       240
     TPLLIHCRDG SQQTGIFCAL LNLLESAETE EVVDIFQVVK ALRKARPGMV STFEQYQFLY       300
     DVIASTYP                                                                308
//
ID   hDEP1_D1\(NP_002834)\PTPRJ STANDARD;PRT;   277 AA.
AC   NP_002834;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, J precursor; protein tyrosine phosphatase, receptor type, J polypeptide; human density enhanced phosphatase-1; CD148 antigen [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from U10886.1.
CC   On Feb 22, 2002 this sequence version replaced gi:4506315.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP possesses an extracellular
CC   region containing five fibronectin type III repeats, a single
CC   transmembrane region, and a single intracytoplasmic catalytic
CC   domain, and thus represents a receptor-type PTP. This PTP is
CC   present in all hematopoietic lineages, and was shown to negatively
CC   regulate T cell receptor signaling possibly through interfering
CC   with the phosphorylation of Phospholipase C Gamma 1 (PLCG1) and
CC   Linker for Activation of T Cells (LAT). This PTP was also found to
CC   dephosphorylate PDGF beta receptor, and may be involved in
CC   UV-induced signal transduction.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1337)
CC   GPRFLN|  AUTHORS   Ruivenkamp,C.A., van Wezel,T., Zanon,C., Stassen,A.P., Vlcek,C.,
CC   GPRFLN|            Csikos,T., Klous,A.M., Tripodis,N., Perrakis,A., Boerrigter,L.,
CC   GPRFLN|            Groot,P.C., Lindeman,J., Mooi,W.J., Meijjer,G.A., Scholten,G.,
CC   GPRFLN|            Dauwerse,H., Paces,V., van Zandwijk,N., van Ommen,G.J. and
CC   GPRFLN|            Demant,P.
CC   GPRFLN|  TITLE     Ptprj is a candidate for the mouse colon-cancer susceptibility
CC   GPRFLN|            locus Scc1 and is frequently deleted in human cancers
CC   GPRFLN|  JOURNAL   Nat. Genet. 31 (3), 295-300 (2002)
CC   GPRFLN|  MEDLINE   22084388
CC   GPRFLN|  REMARK    GeneRIF: This protein is frequently deleted in human breast
CC   GPRFLN|            cancers.
CC   GPRFLN|REFERENCE   2  (residues 1 to 1337)
CC   GPRFLN|  AUTHORS   Baker,J.E., Majeti,R., Tangye,S.G. and Weiss,A.
CC   GPRFLN|  TITLE     Protein tyrosine phosphatase CD148-mediated inhibition of T-cell
CC   GPRFLN|            receptor signal transduction is associated with reduced LAT and
CC   GPRFLN|            phospholipase Cgamma1 phosphorylation
CC   GPRFLN|  JOURNAL   Mol. Cell. Biol. 21 (7), 2393-2403 (2001)
CC   GPRFLN|  MEDLINE   21160271
CC   GPRFLN|REFERENCE   3  (residues 1 to 1337)
CC   GPRFLN|  AUTHORS   Kovalenko,M., Denner,K., Sandstrom,J., Persson,C., Gross,S.,
CC   GPRFLN|            Jandt,E., Vilella,R., Bohmer,F. and Ostman,A.
CC   GPRFLN|  TITLE     Site-selective dephosphorylation of the platelet-derived growth
CC   GPRFLN|            factor beta-receptor by the receptor-like protein-tyrosine
CC   GPRFLN|            phosphatase DEP-1
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 275 (21), 16219-16226 (2000)
CC   GPRFLN|  MEDLINE   20283660
CC   GPRFLN|REFERENCE   4  (residues 1 to 1337)
CC   GPRFLN|  AUTHORS   Gross,S., Knebel,A., Tenev,T., Neininger,A., Gaestel,M.,
CC   GPRFLN|            Herrlich,P. and Bohmer,F.D.
CC   GPRFLN|  TITLE     Inactivation of protein-tyrosine phosphatases as mechanism of
CC   GPRFLN|            UV-induced signal transduction
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 274 (37), 26378-26386 (1999)
CC   GPRFLN|  MEDLINE   99403084
CC   GPRFLN|REFERENCE   5  (residues 1 to 1337)
CC   GPRFLN|  AUTHORS   Tangye,S.G., Phillips,J.H., Lanier,L.L., de Vries,J.E. and
CC   GPRFLN|            Aversa,G.
CC   GPRFLN|  TITLE     CD148: a receptor-type protein tyrosine phosphatase involved in the
CC   GPRFLN|            regulation of human T cell activation
CC   GPRFLN|  JOURNAL   J. Immunol. 161 (7), 3249-3255 (1998)
CC   GPRFLN|  MEDLINE   98430639
CC   GPRFLN|REFERENCE   6  (residues 1 to 1337)
CC   GPRFLN|  AUTHORS   de la Fuente-Garcia,M.A., Nicolas,J.M., Freed,J.H., Palou,E.,
CC   GPRFLN|            Thomas,A.P., Vilella,R., Vives,J. and Gaya,A.
CC   GPRFLN|  TITLE     CD148 is a membrane protein tyrosine phosphatase present in all
CC   GPRFLN|            hematopoietic lineages and is involved in signal transduction on
CC   GPRFLN|            lymphocytes
CC   GPRFLN|  JOURNAL   Blood 91 (8), 2800-2809 (1998)
CC   GPRFLN|  MEDLINE   98200586
CC   GPRFLN|REFERENCE   7  (residues 1 to 1337)
CC   GPRFLN|  AUTHORS   Honda,H., Inazawa,J., Nishida,J., Yazaki,Y. and Hirai,H.
CC   GPRFLN|  TITLE     Molecular cloning, characterization, and chromosomal localization
CC   GPRFLN|            of a novel protein-tyrosine phosphatase, HPTP eta
CC   GPRFLN|  JOURNAL   Blood 84 (12), 4186-4194 (1994)
CC   GPRFLN|  MEDLINE   95086212
CC   GPRFLN|REFERENCE   8  (residues 1 to 1337)
CC   GPRFLN|  AUTHORS   Ostman,A., Yang,Q. and Tonks,N.K.
CC   GPRFLN|  TITLE     Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase,
CC   GPRFLN|            is enhanced with increasing cell density
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 91 (21), 9680-9684 (1994)
CC   GPRFLN|  MEDLINE   95024024
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    277       VNTIFKEY:269
FT   PROTEIN       1    277       protein tyrosine phosphatase, receptor type, J polypeptide; human density enhanced phosphatase-1; CD148 antigen
FT                                VNTIFKEY:270
FT   CHAIN         1    277       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       17    277       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   277 AA;
     ENFEAYFKKQ QADSNCGFAE EYEDLKLVGI SQPKYAAELA ENRGKNRYNN VLPYDISRVK        60
     LSVQTHSTDD YINANYMPGY HSKKDFIATQ GPLPNTLKDF WRMVWEKNVY AIIMLTKCVE       120
     QGRTKCEEYW PSKQAQDYGD ITVAMTSEIV LPEWTIRDFT VKNIQTSESH PLRQFHFTSW       180
     PDHGVPDTTD LLINFRYLVR DYMKQSPPES PILVHCSAGV GRTGTFIAID RLIYQIENEN       240
     TVDVYGIVYD LRMHRPLMVQ TEDQYVFLNQ CVLDIVR                                277
//
ID   hGLEPP1_D1\(NP_109592)\PTPRO STANDARD;PRT;   277 AA.
AC   NP_109592;
DT   27-JUN-2003
DE   receptor-type protein tyrosine phosphatase O isoform a precursor; glomerular epithelial protein-1; protein tyrosine phosphatase PTP-U2; phosphotyrosine phosphatase U2; PTPase U2; PTPROt [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from Z48541.1 and U20489.1.
CC   
CC   Summary: This gene encodes a receptor-type protein tyrosine
CC   phosphatase containing a single intracellular catalytic domain with
CC   a characteristic signature motif. The gene product, which has a
CC   transmembrane domain, is an integral membrane protein. Several
CC   alternatively spliced transcript variants, some of which encode
CC   different isoforms of the protein, have been described. These
CC   variants exhibit tissue-specific expression.
CC   
CC   Transcript Variant: This variant (1) encodes the longest isoform
CC   (a) known to date. The encoded protein has a large extracellular
CC   domain containing 8 repeats of a fibronectin type III-like motif.
CC   This variant is expressed in the glomerulus of kidney and in brain.
CC   In kidney, it may play a role in regulating glomerular epithelial
CC   cell (podocyte) structure and/or function.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1216)
CC   GPRFLN|  AUTHORS   Aguiar,R.C., Yakushijin,Y., Kharbanda,S., Tiwari,S., Freeman,G.J.
CC   GPRFLN|            and Shipp,M.A.
CC   GPRFLN|  TITLE     PTPROt: an alternatively spliced and developmentally regulated
CC   GPRFLN|            B-lymphoid phosphatase that promotes G0/G1 arrest
CC   GPRFLN|  JOURNAL   Blood 94 (7), 2403-2413 (1999)
CC   GPRFLN|  MEDLINE   99428326
CC   GPRFLN|REFERENCE   2  (residues 1 to 1216)
CC   GPRFLN|  AUTHORS   Seimiya,H., Sawabe,T., Inazawa,J. and Tsuruo,T.
CC   GPRFLN|  TITLE     Cloning, expression and chromosomal localization of a novel gene
CC   GPRFLN|            for protein tyrosine phosphatase (PTP-U2) induced by various
CC   GPRFLN|            differentiation-inducing agents
CC   GPRFLN|  JOURNAL   Oncogene 10 (9), 1731-1738 (1995)
CC   GPRFLN|  MEDLINE   95273089
CC   GPRFLN|REFERENCE   3  (residues 1 to 1216)
CC   GPRFLN|  AUTHORS   Wiggins,R.C., Wiggins,J.E., Goyal,M., Wharram,B.L. and Thomas,P.E.
CC   GPRFLN|  TITLE     Molecular cloning of cDNAs encoding human GLEPP1, a membrane
CC   GPRFLN|            protein tyrosine phosphatase: characterization of the GLEPP1
CC   GPRFLN|            protein distribution in human kidney and assignment of the GLEPP1
CC   GPRFLN|            gene to human chromosome 12p12-p13
CC   GPRFLN|  JOURNAL   Genomics 27 (1), 174-181 (1995)
CC   GPRFLN|  MEDLINE   95394455
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|JNA|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   REGION       17    272       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_2
FT   DOMAIN      214    224       VNTIFKEY:1000; VNTINAME:Dom_Misc_3
SQ   SEQUENCE   277 AA;
     DDFDAYIKDM AKDSDYKFSL QFEELKLIGL DIPHFAADLP LNRCKNRYTN ILPYDFSRVR        60
     LVSMNEEEGA DYINANYIPG YNSPQEYIAT QGPLPETRND FWKMVLQQKS QIIVMLTQCN       120
     EKRRVKCDHY WPFTEEPIAY GDITVEMISE EEQDDWACRH FRINYADEMQ DVMHFNYTAW       180
     PDHGVPTANA AESILQFVHM VRQQATKSKG PMIIHCSAGV GRTGTFIALD RLLQHIRDHE       240
     FVDILGLVSE MRSYRMSMVQ TEEQYIFIHQ CVQLMWM                                277
//
ID   hHDPTP_D1\(NP_056281)\PTPN23 STANDARD;PRT;   286 AA.
AC   NP_056281;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, non-receptor type 23; His-domain protein tyrosine phosphatase [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   PREDICTED REFSEQ: The mRNA record is supported by experimental
CC   evidence; however, the coding sequence is predicted. The reference
CC   sequence was derived from AF290614.1.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1636)
CC   GPRFLN|  AUTHORS   Qu,X., Zhai,Y., Wei,H., Zhang,C., Xing,G., Lu,C., Wang,M. and He,F.
CC   GPRFLN|  TITLE     Cloning, chromosomal assignment and tissue expression of a novel
CC   GPRFLN|            human protein tyrosine phosphatase (PTP-TD14) gene
CC   GPRFLN|  JOURNAL   I Chuan 23 (6), 1-9 (2001)
CC   GPRFLN|REFERENCE   2  (residues 1 to 1636)
CC   GPRFLN|  AUTHORS   Toyooka,S., Ouchida,M., Jitsumori,Y., Tsukuda,K., Sakai,A.,
CC   GPRFLN|            Nakamura,A., Shimizu,N. and Shimizu,K.
CC   GPRFLN|  TITLE     HD-PTP: A novel protein tyrosine phosphatase gene on human
CC   GPRFLN|            chromosome 3p21.3
CC   GPRFLN|  JOURNAL   Biochem. Biophys. Res. Commun. 278 (3), 671-678 (2000)
CC   GPRFLN|  MEDLINE   20549011
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    286       VNTIFKEY:269
FT   PROTEIN       1    286       His-domain protein tyrosine phosphatase
FT                                VNTIFKEY:270
FT   REGION       23    286       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_2
SQ   SEQUENCE   286 AA;
     ERLRQLQQEL EAFRGQLGDV GALDTVWREL QDAQEHDARG RSIAIARCYS LKNRHQDVMP        60
     YDSNRVVLRS GKDDYINASC VEGLSPYCPP LVATQAPLPG TAADFWLMVH EQKVSVIVML       120
     VSEAEMEKQK VARYFPTERG QPMVHGALSL ALSSVRSTET HVERVLSLQF RDQSLKRSLV       180
     HLHFPTWPEL GLPDSPSNLL RFIQEVHAHY LHQRPLHTPI IVHCSSGVGR TGAFALLYAA       240
     VQEVEAGNGI PELPQLVRRM RQQRKHMLQE KLHLRFCYEA VVRHVE                      286
//
ID   hHePTP_D1\(NP_002823)\PTPN7 STANDARD;PRT;   273 AA.
AC   NP_002823;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, non-receptor type 7 isoform 1; protein-tyrosine phoshatase, nonreceptor-type, stress induced; hematopoietic protein-tyrosine phosphatase [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from BC001746.1, BG340453.1,
CC   D11327.1 and M64322.1.
CC   On Jan 25, 2002 this sequence version replaced gi:4506299.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This gene is preferentially expressed in
CC   a variety of hematopoietic cells, and is an early response gene in
CC   lymphokine stimulated cells. The noncatalytic N-terminus of this
CC   PTP can interact with MAP kinases and suppress the MAP kinase
CC   activities. This PTP was shown to be involved in the regulation of
CC   T cell antigen receptor (TCR) signaling, which was thought to
CC   function through dephosphorylating the molecules related to MAP
CC   kinase pathway. Three alternatively spliced transcript variants of
CC   this gene, which encode two distinct isoforms, are reported.
CC   
CC   Transcript Variant: This variant (1) contains a different 5'
CC   region, which includes a part of the coding sequence when compared
CC   to variant 2. It thus encodes a protein that has a shorter
CC   N-terminus, as compared to isoform 2.
CC   GPRFLN|REFERENCE   1  (residues 1 to 360)
CC   GPRFLN|  AUTHORS   Oh-hora,M., Ogata,M., Mori,Y., Adachi,M., Imai,K., Kosugi,A. and
CC   GPRFLN|            Hamaoka,T.
CC   GPRFLN|  TITLE     Direct suppression of TCR-mediated activation of extracellular
CC   GPRFLN|            signal-regulated kinase by leukocyte protein tyrosine phosphatase,
CC   GPRFLN|            a tyrosine-specific phosphatase
CC   GPRFLN|  JOURNAL   J. Immunol. 163 (3), 1282-1288 (1999)
CC   GPRFLN|  MEDLINE   99343735
CC   GPRFLN|REFERENCE   2  (residues 1 to 360)
CC   GPRFLN|  AUTHORS   Saxena,M., Williams,S., Brockdorff,J., Gilman,J. and Mustelin,T.
CC   GPRFLN|  TITLE     Inhibition of T cell signaling by mitogen-activated protein
CC   GPRFLN|            kinase-targeted hematopoietic tyrosine phosphatase (HePTP)
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 274 (17), 11693-11700 (1999)
CC   GPRFLN|  MEDLINE   99223488
CC   GPRFLN|REFERENCE   3  (residues 1 to 360)
CC   GPRFLN|  AUTHORS   Saxena,M., Williams,S., Gilman,J. and Mustelin,T.
CC   GPRFLN|  TITLE     Negative regulation of T cell antigen receptor signal transduction
CC   GPRFLN|            by hematopoietic tyrosine phosphatase (HePTP)
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 273 (25), 15340-15344 (1998)
CC   GPRFLN|  MEDLINE   98288260
CC   GPRFLN|REFERENCE   4  (residues 1 to 360)
CC   GPRFLN|  AUTHORS   Swieter,M., Berenstein,E.H., Swaim,W.D. and Siraganian,R.P.
CC   GPRFLN|  TITLE     Aggregation of IgE receptors in rat basophilic leukemia 2H3 cells
CC   GPRFLN|            induces tyrosine phosphorylation of the cytosolic protein-tyrosine
CC   GPRFLN|            phosphatase HePTP
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 270 (37), 21902-21906 (1995)
CC   GPRFLN|  MEDLINE   95394959
CC   GPRFLN|REFERENCE   5  (residues 1 to 360)
CC   GPRFLN|  AUTHORS   Adachi,M., Sekiya,M., Isobe,M., Kumura,Y., Ogita,Z., Hinoda,Y.,
CC   GPRFLN|            Imai,K. and Yachi,A.
CC   GPRFLN|  TITLE     Molecular cloning and chromosomal mapping of a human
CC   GPRFLN|            protein-tyrosine phosphatase LC-PTP
CC   GPRFLN|  JOURNAL   Biochem. Biophys. Res. Commun. 186 (3), 1607-1615 (1992)
CC   GPRFLN|  MEDLINE   92378634
CC   GPRFLN|REFERENCE   6  (residues 1 to 360)
CC   GPRFLN|  AUTHORS   Adachi,M., Sekiya,M., Arimura,Y., Takekawa,M., Itoh,F., Hinoda,Y.,
CC   GPRFLN|            Imai,K. and Yachi,A.
CC   GPRFLN|  TITLE     Protein-tyrosine phosphatase expression in pre-B cell NALM-6
CC   GPRFLN|  JOURNAL   Cancer Res. 52 (3), 737-740 (1992)
CC   GPRFLN|  MEDLINE   92119637
CC   GPRFLN|REFERENCE   7  (sites)
CC   GPRFLN|  AUTHORS   Zanke,B., Suzuki,H., Kishihara,K., Mizzen,L., Minden,M., Pawson,A.
CC   GPRFLN|            and Mak,T.W.
CC   GPRFLN|  TITLE     Cloning and expression of an inducible lymphoid-specific, protein
CC   GPRFLN|            tyrosine phosphatase (HePTPase)
CC   GPRFLN|  JOURNAL   Eur. J. Immunol. 22 (1), 235-239 (1992)
CC   GPRFLN|  MEDLINE   92111631
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    273       VNTIFKEY:269
FT   PROTEIN       1    273       protein-tyrosine phoshatase, nonreceptor-type, stress induced; hematopoietic protein-tyrosine phosphatase
FT                                VNTIFKEY:270
FT   REGION       17    271       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   273 AA;
     HPLTRWALQR QPPSPKQLEE EFLKIPSNFV SPEDLDIPGH ASKDRYKTIL PNPQSRVCLG        60
     RAQSQEDGDY INANYIRGYD GKEKVYIATQ GPMPNTVSDF WEMVWQEEVS LIVMLTQLRE       120
     GKEKCVHYWP TEEETYGPFQ IRIQDMKECP EYTVRQLTIQ YQEERRSVKH ILFSAWPDHQ       180
     TPESAGPLLR LVAEVEESPE TAAHPGPIVV HCSAGIGRTG CFIATRIGCQ QLKARGEVDI       240
     LGIVCQLRLD RGGMIQTAEQ YQFLHHTLAL YAG                                    273
//
ID   hIA2_D1\(NP_002837)\PTPRN STANDARD;PRT;   279 AA.
AC   NP_002837;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, N precursor; islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N precursor [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from L18983.1, AF042285.4 and
CC   BC007713.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP possesses an extracellular
CC   region, a single transmembrane region, and a single catalytic
CC   domain, and thus represents a receptor-type PTP. This PTP was found
CC   to be an autoantigen that is reactive with insulin-dependent
CC   diabetes mellitus (IDDM) patient sera, and thus may be a potential
CC   target of autoimmunity in diabetes mellitus.
CC   GPRFLN|REFERENCE   1  (residues 1 to 979)
CC   GPRFLN|  AUTHORS   Sanjeevi,C.B., Das,A.K. and Shtauvere-Brameus,A.
CC   GPRFLN|  TITLE     BCG vaccination and GAD65 and IA-2 autoantibodies in autoimmune
CC   GPRFLN|            diabetes in southern India
CC   GPRFLN|  JOURNAL   Ann. N. Y. Acad. Sci. 958, 293-296 (2002)
CC   GPRFLN|  MEDLINE   22015049
CC   GPRFLN|  REMARK    GeneRIF: BCG vaccination and GAD65 and IA-2 autoantibodies in
CC   GPRFLN|            autoimmune diabetes in southern India.
CC   GPRFLN|REFERENCE   2  (residues 1 to 979)
CC   GPRFLN|  AUTHORS   Kawasaki,E., Yamaguchi,H., Hattori,H., Egashira,T. and Eguchi,K.
CC   GPRFLN|  TITLE     Autoantibodies to IA-2 in type 1 diabetes: measurements with a new
CC   GPRFLN|            enzyme-linked immunosorbent assay
CC   GPRFLN|  JOURNAL   Ann. N. Y. Acad. Sci. 958, 241-246 (2002)
CC   GPRFLN|  MEDLINE   22015037
CC   GPRFLN|  REMARK    GeneRIF: Autoantibodies to IA-2 in type 1 diabetes: measurements
CC   GPRFLN|            with a new enzyme-linked immunosorbent assay.
CC   GPRFLN|REFERENCE   3  (residues 1 to 979)
CC   GPRFLN|  AUTHORS   Miao,D., Yu,L., Tiberti,C., Cuthbertson,D.D., Rewers,M., di
CC   GPRFLN|            Mario,U., Eisenbarth,G.S. and Dotta,F.
CC   GPRFLN|  TITLE     ICA512(IA-2) epitope specific assays distinguish transient from
CC   GPRFLN|            diabetes associated autoantibodies
CC   GPRFLN|  JOURNAL   J. Autoimmun. 18 (2), 191-196 (2002)
CC   GPRFLN|  MEDLINE   21906940
CC   GPRFLN|  REMARK    GeneRIF: ICA512(IA-2) epitope specific assays distinguish transient
CC   GPRFLN|            from diabetes associated autoantibodies.
CC   GPRFLN|REFERENCE   4  (residues 1 to 979)
CC   GPRFLN|  AUTHORS   Mikulecky,M. and Michalkova,D.
CC   GPRFLN|  TITLE     Secular and seasonal cycling of IA2-ab autoantibody in Slovak
CC   GPRFLN|            diabetic children
CC   GPRFLN|  JOURNAL   Biomed. Pharmacother. 55 Suppl 1, 106S-109S (2001)
CC   GPRFLN|  MEDLINE   21630621
CC   GPRFLN|REFERENCE   5  (residues 1 to 979)
CC   GPRFLN|  AUTHORS   Cui,L., Yu,W.P., DeAizpurua,H.J., Schmidli,R.S. and Pallen,C.J.
CC   GPRFLN|  TITLE     Cloning and characterization of islet cell antigen-related
CC   GPRFLN|            protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and
CC   GPRFLN|            autoantigen in insulin-dependent diabetes
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 271 (40), 24817-24823 (1996)
CC   GPRFLN|  MEDLINE   96394649
CC   GPRFLN|REFERENCE   6  (residues 1 to 979)
CC   GPRFLN|  AUTHORS   van den Maagdenberg,A.M., Olde Weghuis,D., Rijss,J., van de
CC   GPRFLN|            Wetering,R.A., Wieringa,B., Geurts van Kessel,A. and Hendriks,W.J.
CC   GPRFLN|  TITLE     Assignment of the human gene for receptor-type protein tyrosine
CC   GPRFLN|            phosphatase IA-2 (PTPRN) to chromosome region 2q35 --> q36.1 and
CC   GPRFLN|            identification of an intragenic genetic marker
CC   GPRFLN|  JOURNAL   Cytogenet. Cell Genet. 73 (1-2), 145-148 (1996)
CC   GPRFLN|  MEDLINE   96244610
CC   GPRFLN|REFERENCE   7  (residues 1 to 979)
CC   GPRFLN|  AUTHORS   Lan,M.S., Lu,J., Goto,Y. and Notkins,A.L.
CC   GPRFLN|  TITLE     Molecular cloning and identification of a receptor-type protein
CC   GPRFLN|            tyrosine phosphatase, IA-2, from human insulinoma
CC   GPRFLN|  JOURNAL   DNA Cell Biol. 13 (5), 505-514 (1994)
CC   GPRFLN|  MEDLINE   94296553
CC   GPRFLN|REFERENCE   8  (residues 1 to 979)
CC   GPRFLN|  AUTHORS   Rabin,D.U., Pleasic,S.M., Shapiro,J.A., Yoo-Warren,H., Oles,J.,
CC   GPRFLN|            Hicks,J.M., Goldstein,D.E. and Rae,P.M.
CC   GPRFLN|  TITLE     Islet cell antigen 512 is a diabetes-specific islet autoantigen
CC   GPRFLN|            related to protein tyrosine phosphatases
CC   GPRFLN|  JOURNAL   J. Immunol. 152 (6), 3183-3188 (1994)
CC   GPRFLN|  MEDLINE   94194080
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    279       VNTIFKEY:269
FT   PROTEIN       1    279       islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N precursor
FT                                VNTIFKEY:270
FT   CHAIN         1    279       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       17    278       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   279 AA;
     HMILAYMEDH LRNRDRLAKE WQALCAYQAE PNTCATAQGE GNIKKNRHPD FLPYDHARIK        60
     LKVESSPSRS DYINASPIIE HDPRMPAYIA TQGPLSHTIA DFWQMVWESG CTVIVMLTPL       120
     VEDGVKQCDR YWPDEGASLY HVYEVNLVSE HIWCEDFLVR SFYLKNVQTQ ETRTLTQFHF       180
     LSWPAEGTPA STRPLLDFRR KVNKCYRGRS CPIIVHCSDG AGRTGTYILI DMVLNRMAKG       240
     VKEIDIAATL EHVRDQRPGL VRSKDQFEFA LTAVAEEVN                              279
//
ID   hIA2beta_D1\(NP_002838)\PTPRN2 STANDARD;PRT;   279 AA.
AC   NP_002838;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, N polypeptide 2 isoform 1 precursor; protein tyrosine phosphatase receptor pi; phogrin; tyrosine phosphatase IA-2 beta; IAR/receptor-like protein-tyrosine phosphatase [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from U66702.1 and AF007555.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP possesses an extracellular
CC   region, a single transmembrane region, and a single intracellular
CC   catalytic domain, and thus represents a receptor-type PTP. The
CC   catalytic domain of this PTP is most closely related to
CC   PTPRN/IA-2beta. This PTP and PTPRN are both found to be major
CC   autoantigens associated with insulin-dependent diabetes mellitus.
CC   Three alternatively spliced transcript variants of this gene, which
CC   encode distinct proteins, have been reported.
CC   
CC   Transcript Variant: This variant (1) encodes the longest isoform
CC   (1).
CC   GPRFLN|REFERENCE   1  (residues 1 to 1015)
CC   GPRFL