ID   hBDP1_D1\(NP_055184)\PTPN18 STANDARD;PRT;   288 AA.
AC   NP_055184;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, non-receptor type 18; brain-derived phosphatase [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from X79568.1 and BI261717.1.
CC   On Jan 25, 2002 this sequence version replaced gi:7657484.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP contains a PEST motif, which
CC   often serves as a protein-protein interaction domain, and may be
CC   related to protein intracellular half-live. This gene was found to
CC   be expressed in brain, colon tissues, and several different
CC   tumor-derived cell lines. The bilogical function of this PTP has
CC   not yet been determined.
CC   GPRFLN|REFERENCE   1  (residues 1 to 460)
CC   GPRFLN|  AUTHORS   Kim,Y.W., Wang,H., Sures,I., Lammers,R., Martell,K.J. and
CC   GPRFLN|            Ullrich,A.
CC   GPRFLN|  TITLE     Characterization of the PEST family protein tyrosine phosphatase
CC   GPRFLN|            BDP1
CC   GPRFLN|  JOURNAL   Oncogene 13 (10), 2275-2279 (1996)
CC   GPRFLN|  MEDLINE   97108674
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    288       VNTIFKEY:269
FT   PROTEIN       1    288       brain-derived phosphatase
FT                                VNTIFKEY:270
FT   REGION       21    287       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   288 AA;
     DSARSFLERL EARGGREGAV LAGEFSDIQA CSAAWKADGV CSTVAGSRPE NVRKNRYKDV        60
     LPYDQTRVIL SLLQEEGHSD YINGNFIRGV DGSLAYIATQ GPLPHTLLDF WRLVWEFGVK       120
     VILMACREIE NGRKRCERYW AQEQEPLQTG LFCITLIKEK WLNEDIMLRT LKVTFQKESR       180
     SVYQLQYMSW PDRGVPSSPD HMLAMVEEAR RLQGSGPEPL CVHCSAGCGR TGVLCTVDYV       240
     RQLLLTQMIP PDFSLFDVVL KMRKQRPAAV QTEEQYRFLY HTVAQMFC                    288
//
ID   hCD45_D1\(NP_002829)\PTPRC STANDARD;PRT;   279 AA.
AC   NP_002829;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, C isoform 1 precursor; protein tyrosine phosphatase, receptor type, c polypeptide; leukocyte-common antigen; T200 glycoprotein; human homolog of severe combined immunodeficiency due to PTPRC deficiency; SCID due to PTPRC deficiency; CD45 antigen [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from Y00638.1 and Y00062.1.
CC   On Feb 8, 2002 this sequence version replaced gi:4506307.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP contains an extracellular
CC   domain, a single transmembrane segment and two tandem
CC   intracytoplasmic catalytic domains, and thus belongs to receptor
CC   type PTP. This gene is specifically expressed in hematopoietic
CC   cells. This PTP has been shown to be an essential regulator of T-
CC   and B-cell antigen receptor signaling. It functions through either
CC   direct interaction with components of the antigen receptor
CC   complexes, or by activating various Src family kinases required for
CC   the antigen receptor signaling. This PTP also suppresses JAK
CC   kinases, and thus functions as a regulator of cytokine receptor
CC   signaling. Four alternatively spliced transcripts variants of this
CC   gene, which encode distinct isoforms, have been reported.
CC   
CC   Transcript Variant: This variant (1) encodes the longest isoform
CC   (1).
CC   GPRFLN|REFERENCE   1  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Baldwin,T.A. and Ostergaard,H.L.
CC   GPRFLN|  TITLE     The protein-tyrosine phosphatase CD45 reaches the cell surface via
CC   GPRFLN|            golgi-dependent and -independent pathways
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (52), 50333-50340 (2002)
CC   GPRFLN|  MEDLINE   22384317
CC   GPRFLN|  REMARK    GeneRIF: reaches the cell surface via Golgi-dependent and
CC   GPRFLN|            -independent pathways
CC   GPRFLN|REFERENCE   2  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Harashima,A., Suzuki,M., Okochi,A., Yamamoto,M., Matsuo,Y.,
CC   GPRFLN|            Motoda,R., Yoshioka,T. and Orita,K.
CC   GPRFLN|  TITLE     CD45 tyrosine phosphatase inhibits erythroid differentiation of
CC   GPRFLN|            umbilical cord blood CD34+ cells associated with selective
CC   GPRFLN|            inactivation of Lyn
CC   GPRFLN|  JOURNAL   Blood 100 (13), 4440-4445 (2002)
CC   GPRFLN|  MEDLINE   22340750
CC   GPRFLN|  REMARK    GeneRIF: CD45 may play a pivotal role in erythropoiesis. CD45
CC   GPRFLN|            tyrosine phosphatase inhibits erythroid differentiation of
CC   GPRFLN|            umbilical cord blood CD34+ cells associated with selective
CC   GPRFLN|            inactivation of Lyn.
CC   GPRFLN|REFERENCE   3  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J.
CC   GPRFLN|  TITLE     Intra- and intermolecular interactions between intracellular
CC   GPRFLN|            domains of receptor protein-tyrosine phosphatases
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (49), 47263-47269 (2002)
CC   GPRFLN|  MEDLINE   22344739
CC   GPRFLN|  REMARK    GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are
CC   GPRFLN|            a common but specific mechanism that is likely to be regulated-
CC   GPRFLN|            domain2s and the wedge structures are crucial determinants of
CC   GPRFLN|            binding specificity, thus regulating cross-talk between RPTPs
CC   GPRFLN|REFERENCE   4  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Pradhan,D. and Morrow,J.
CC   GPRFLN|  TITLE     The spectrin-ankyrin skeleton controls CD45 surface display and
CC   GPRFLN|            interleukin-2 production
CC   GPRFLN|  JOURNAL   Immunity 17 (3), 303-315 (2002)
CC   GPRFLN|  MEDLINE   22241694
CC   GPRFLN|  REMARK    GeneRIF: The spectrin-ankyrin skeleton controls CD45 surface
CC   GPRFLN|            display and interleukin-2 production.
CC   GPRFLN|REFERENCE   5  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Ballerini,C., Rosati,E., Salvetti,M., Ristori,G., Cannoni,S.,
CC   GPRFLN|            Biagioli,T., Massacesi,L., Sorbi,S. and Vergelli,M.
CC   GPRFLN|  TITLE     Protein tyrosine phosphatase receptor-type C exon 4 gene mutation
CC   GPRFLN|            distribution in an Italian multiple sclerosis population
CC   GPRFLN|  JOURNAL   Neurosci. Lett. 328 (3), 325-327 (2002)
CC   GPRFLN|  MEDLINE   22142931
CC   GPRFLN|  REMARK    GeneRIF: Role of the C-->G mutation in position 77 of exon 4 of the
CC   GPRFLN|            protein tyrosine phosphatase receptor-type C (PTPRC) gene, coding
CC   GPRFLN|            for the CD45 molecule, for the development of multiple sclerosis
CC   GPRFLN|            (MS) in Italy.
CC   GPRFLN|REFERENCE   6  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Yamada,T., Zhu,D., Saxon,A. and Zhang,K.
CC   GPRFLN|  TITLE     CD45 controls interleukin-4-mediated IgE class switch recombination
CC   GPRFLN|            in human B cells through its function as a Janus kinase phosphatase
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (32), 28830-28835 (2002)
CC   GPRFLN|  MEDLINE   22151051
CC   GPRFLN|  REMARK    GeneRIF: CD45 controls interleukin-4-mediated IgE class switch
CC   GPRFLN|            recombination in human B cells
CC   GPRFLN|REFERENCE   7  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Yu,C., Yu,H.S., Sun,K.H., Hsieh,S.C. and Tsai,C.Y.
CC   GPRFLN|  TITLE     Anti-CD45 isoform antibodies enhance phagocytosis and gene
CC   GPRFLN|            expression of IL-8 and TNF-alpha in human neutrophils by
CC   GPRFLN|            differential suppression on protein tyrosine phosphorylation and
CC   GPRFLN|            p56lck tyrosine kinase
CC   GPRFLN|  JOURNAL   Clin. Exp. Immunol. 129 (1), 78-85 (2002)
CC   GPRFLN|  MEDLINE   22095000
CC   GPRFLN|  REMARK    GeneRIF: Biological functions of membrane expressed CD45 isoforms
CC   GPRFLN|            on PMNs were studied. Cross-linking of CD45 isoforms by specific
CC   GPRFLN|            MAbs stimulated different PMN activities by differential
CC   GPRFLN|            suppression on protein tyrosine phosphorylation and p56lck.
CC   GPRFLN|REFERENCE   8  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Jacobsen,M., Hoffmann,S., Cepok,S., Stei,S., Ziegler,A., Sommer,N.
CC   GPRFLN|            and Hemmer,B.
CC   GPRFLN|  TITLE     A novel mutation in PTPRC interferes with splicing and alters the
CC   GPRFLN|            structure of the human CD45 molecule
CC   GPRFLN|  JOURNAL   Immunogenetics 54 (3), 158-163 (2002)
CC   GPRFLN|  MEDLINE   22067726
CC   GPRFLN|  REMARK    GeneRIF: a mutation in PTPRC interferes with splicing and alters
CC   GPRFLN|            the structure of the CD45 molecule
CC   GPRFLN|REFERENCE   9  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Tchilian,E.Z. and Beverley,P.C.
CC   GPRFLN|  TITLE     CD45 in memory and disease
CC   GPRFLN|  JOURNAL   Arch. Immunol. Ther. Exp. (Warsz.) 50 (2), 85-93 (2002)
CC   GPRFLN|  MEDLINE   22017393
CC   GPRFLN|  REMARK    GeneRIF: Role of high and low molecular weight isoforms of CD45 in
CC   GPRFLN|            the function of na##ve and memory T lymphocytes. Review.
CC   GPRFLN|REFERENCE   10 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Fajka-Boja,R., Szemes,M., Ion,G., Legradi,A., Caron,M. and
CC   GPRFLN|            Monostori,E.
CC   GPRFLN|  TITLE     Receptor tyrosine phosphatase, CD45 binds galectin-1 but does not
CC   GPRFLN|            mediate its apoptotic signal in T cell lines
CC   GPRFLN|  JOURNAL   Immunol. Lett. 82 (1-2), 149-154 (2002)
CC   GPRFLN|  MEDLINE   22003829
CC   GPRFLN|  REMARK    GeneRIF: Receptor tyrosine phosphatase, CD45 binds galectin-1 but
CC   GPRFLN|            does not mediate its apoptotic signal in Jurkat cells
CC   GPRFLN|REFERENCE   11 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Fukuhara,K., Okumura,M., Shiono,H., Inoue,M., Kadota,Y., Miyoshi,S.
CC   GPRFLN|            and Matsuda,H.
CC   GPRFLN|  TITLE     A study on CD45 isoform expression during T-cell development and
CC   GPRFLN|            selection events in the human thymus
CC   GPRFLN|  JOURNAL   Hum. Immunol. 63 (5), 394-404 (2002)
CC   GPRFLN|  MEDLINE   21972715
CC   GPRFLN|  REMARK    GeneRIF: analysis of CD45 isoform expression during T-cell
CC   GPRFLN|            development and selection in the human thymus
CC   GPRFLN|REFERENCE   12 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Wu,L., Fu,J. and Shen,S.H.
CC   GPRFLN|  TITLE     SKAP55 coupled with CD45 positively regulates T-cell
CC   GPRFLN|            receptor-mediated gene transcription
CC   GPRFLN|  JOURNAL   Mol. Cell. Biol. 22 (8), 2673-2686 (2002)
CC   GPRFLN|  MEDLINE   21907230
CC   GPRFLN|  REMARK    GeneRIF: SKAP55 coupled with CD45 positively regulates T-cell
CC   GPRFLN|            receptor-mediated gene transcription.
CC   GPRFLN|REFERENCE   13 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Ishikawa,H., Tsuyama,N., Abroun,S., Liu,S., Li,F.J., Taniguchi,O.
CC   GPRFLN|            and Kawano,M.M.
CC   GPRFLN|  TITLE     Requirements of src family kinase activity associated with CD45 for
CC   GPRFLN|            myeloma cell proliferation by interleukin-6
CC   GPRFLN|  JOURNAL   Blood 99 (6), 2172-2178 (2002)
CC   GPRFLN|  MEDLINE   21866149
CC   GPRFLN|  REMARK    GeneRIF: Requirements of src family kinase activity associated with
CC   GPRFLN|            CD45 for myeloma cell proliferation by interleukin-6
CC   GPRFLN|REFERENCE   14 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Tchilian,E.Z., Dawes,R., Ramaley,P.A., Whitworth,J.A.,
CC   GPRFLN|            Yuldasheva,N., Wells,R.S., Watera,C., French,N., Gilks,C.F.,
CC   GPRFLN|            Kunachiwa,W., Ruzibakiev,R., Leetrakool,N., Carrington,C.V.,
CC   GPRFLN|            Ramdath,D.D., Gotch,F., Stephens,H.A., Hill,A.V. and Beverley,P.C.
CC   GPRFLN|  TITLE     A CD45 polymorphism associated with abnormal splicing is absent in
CC   GPRFLN|            African populations
CC   GPRFLN|  JOURNAL   Immunogenetics 53 (10-11), 980-983 (2002)
CC   GPRFLN|  MEDLINE   21850514
CC   GPRFLN|  REMARK    GeneRIF: we examined the frequency of the C77G allele in African
CC   GPRFLN|            and Asian populations from countries with high or low prevalence of
CC   GPRFLN|            HIV infection; Here we report that the variant CD45 C77G allele is
CC   GPRFLN|            absent in African populations
CC   GPRFLN|REFERENCE   15 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Wood,J.P., Bieda,K., Segni,M., Herwig,J., Krause,M., Usadel,K.H.
CC   GPRFLN|            and Badenhoop,K.
CC   GPRFLN|  TITLE     CD45 exon 4 point mutation does not confer susceptibility to type 1
CC   GPRFLN|            diabetes mellitus or Graves' disease
CC   GPRFLN|  JOURNAL   Eur. J. Immunogenet. 29 (1), 73-74 (2002)
CC   GPRFLN|  MEDLINE   21830605
CC   GPRFLN|  REMARK    GeneRIF: CD45 variant (C77G, exon 4) does not confer susceptibility
CC   GPRFLN|            to either IDDM or Graves' disease
CC   GPRFLN|REFERENCE   16 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Moro,H., Iwai,K., Mori,N., Watanabe,M., Fukushi,M., Oie,M.,
CC   GPRFLN|            Arai,M., Tanaka,Y., Miyawaki,T., Gejyo,F., Arakawa,M. and Fujii,M.
CC   GPRFLN|  TITLE     Interleukin-2-dependent but not independent T-cell lines infected
CC   GPRFLN|            with human T-cell leukemia virus type 1 selectively express CD45RO,
CC   GPRFLN|            a marker for persistent infection in vivo
CC   GPRFLN|  JOURNAL   Virus Genes 23 (3), 263-271 (2001)
CC   GPRFLN|  MEDLINE   21636965
CC   GPRFLN|  REMARK    GeneRIF: role of CD45RO in the persistent HTLV-1 infection in vivo
CC   GPRFLN|REFERENCE   17 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Irie-Sasaki,J., Sasaki,T., Matsumoto,W., Opavsky,A., Cheng,M.,
CC   GPRFLN|            Welstead,G., Griffiths,E., Krawczyk,C., Richardson,C.D., Aitken,K.,
CC   GPRFLN|            Iscove,N., Koretzky,G., Johnson,P., Liu,P., Rothstein,D.M. and
CC   GPRFLN|            Penninger,J.M.
CC   GPRFLN|  TITLE     CD45 is a JAK phosphatase and negatively regulates cytokine
CC   GPRFLN|            receptor signalling
CC   GPRFLN|  JOURNAL   Nature 409 (6818), 349-354 (2001)
CC   GPRFLN|  MEDLINE   21069057
CC   GPRFLN|REFERENCE   18 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Goff,L.K., van Soest,S., Timon,M., Tchilian,E. and Beverley,P.C.
CC   GPRFLN|  TITLE     Protein tyrosine phosphatase receptor type C polypeptide (PTPRC) on
CC   GPRFLN|            human chromosome band 1q31-->q32 localizes with marker D1S413(1) on
CC   GPRFLN|            a 610-kb yeast artificial chromosome
CC   GPRFLN|  JOURNAL   Cytogenet. Cell Genet. 87 (3-4), 223-224 (1999)
CC   GPRFLN|  MEDLINE   20169194
CC   GPRFLN|REFERENCE   19 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Petricoin,E.F. III, Ito,S., Williams,B.L., Audet,S., Stancato,L.F.,
CC   GPRFLN|            Gamero,A., Clouse,K., Grimley,P., Weiss,A., Beeler,J.,
CC   GPRFLN|            Finbloom,D.S., Shores,E.W., Abraham,R. and Larner,A.C.
CC   GPRFLN|  TITLE     Antiproliferative action of interferon-alpha requires components of
CC   GPRFLN|            T-cell-receptor signalling
CC   GPRFLN|  JOURNAL   Nature 390 (6660), 629-632 (1997)
CC   GPRFLN|  MEDLINE   98065953
CC   GPRFLN|REFERENCE   20 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Kaplan,R., Morse,B., Huebner,K., Croce,C., Howk,R., Ravera,M.,
CC   GPRFLN|            Ricca,G., Jaye,M. and Schlessinger,J.
CC   GPRFLN|  TITLE     Cloning of three human tyrosine phosphatases reveals a multigene
CC   GPRFLN|            family of receptor-linked protein-tyrosine-phosphatases expressed
CC   GPRFLN|            in brain
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (18), 7000-7004 (1990)
CC   GPRFLN|  MEDLINE   90384936
CC   GPRFLN|REFERENCE   21 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Schraven,B., Samstag,Y., Altevogt,P. and Meuer,S.C.
CC   GPRFLN|  TITLE     Association of CD2 and CD45 on human T lymphocytes
CC   GPRFLN|  JOURNAL   Nature 345 (6270), 71-74 (1990)
CC   GPRFLN|  MEDLINE   90231464
CC   GPRFLN|REFERENCE   22 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Pingel,J.T. and Thomas,M.L.
CC   GPRFLN|  TITLE     Evidence that the leukocyte-common antigen is required for
CC   GPRFLN|            antigen-induced T lymphocyte proliferation
CC   GPRFLN|  JOURNAL   Cell 58 (6), 1055-1065 (1989)
CC   GPRFLN|  MEDLINE   89376557
CC   GPRFLN|REFERENCE   23 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Charbonneau,H., Tonks,N.K., Walsh,K.A. and Fischer,E.H.
CC   GPRFLN|  TITLE     The leukocyte common antigen (CD45): a putative receptor-linked
CC   GPRFLN|            protein tyrosine phosphatase
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 85 (19), 7182-7186 (1988)
CC   GPRFLN|  MEDLINE   89017162
CC   GPRFLN|REFERENCE   24 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Streuli,M., Hall,L.R., Saga,Y., Schlossman,S.F. and Saito,H.
CC   GPRFLN|  TITLE     Differential usage of three exons generates at least five different
CC   GPRFLN|            mRNAs encoding human leukocyte common antigens
CC   GPRFLN|  JOURNAL   J. Exp. Med. 166 (5), 1548-1566 (1987)
CC   GPRFLN|  MEDLINE   88061067
CC   GPRFLN|REFERENCE   25 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Ralph,S.J., Thomas,M.L., Morton,C.C. and Trowbridge,I.S.
CC   GPRFLN|  TITLE     Structural variants of human T200 glycoprotein (leukocyte-common
CC   GPRFLN|            antigen)
CC   GPRFLN|  JOURNAL   EMBO J. 6 (5), 1251-1257 (1987)
CC   GPRFLN|  MEDLINE   87275816
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    279       VNTIFKEY:269
FT   PROTEIN       1    279       protein tyrosine phosphatase, receptor type, c polypeptide; leukocyte-common antigen; T200 glycoprotein; human homolog of severe combined immunodeficiency due to PTPRC deficiency; SCID due to PTPRC deficiency; CD45 antigen
FT                                VNTIFKEY:270
FT   CHAIN         1    279       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       17    277       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_2
SQ   SEQUENCE   279 AA;
     DILLETYKRK IADEGRLFLA EFQSIPRVFS KFPIKEARKP FNQNKNRYVD ILPYDYNRVE        60
     LSEINGDAGS NYINASYIDG FKEPRKYIAA QGPRDETVDD FWRMIWEQKA TVIVMVTRCE       120
     EGNRNKCAEY WPSMEEGTRA FGDVVVKINQ HKRCPDYIIQ KLNIVNKKEK ATGREVTHIQ       180
     FTSWPDHGVP EDPHLLLKLR RRVNAFSNFF SGPIVVHCSA GVGRTGTYIG IDAMLEGLEA       240
     ENKVDVYGYV VKLRRQRCLM VQVEAQYILI HQALVEYNQ                              279
//
ID   hDEP1_D1\(NP_002834)\PTPRJ STANDARD;PRT;   277 AA.
AC   NP_002834;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, J precursor; protein tyrosine phosphatase, receptor type, J polypeptide; human density enhanced phosphatase-1; CD148 antigen [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from U10886.1.
CC   On Feb 22, 2002 this sequence version replaced gi:4506315.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP possesses an extracellular
CC   region containing five fibronectin type III repeats, a single
CC   transmembrane region, and a single intracytoplasmic catalytic
CC   domain, and thus represents a receptor-type PTP. This PTP is
CC   present in all hematopoietic lineages, and was shown to negatively
CC   regulate T cell receptor signaling possibly through interfering
CC   with the phosphorylation of Phospholipase C Gamma 1 (PLCG1) and
CC   Linker for Activation of T Cells (LAT). This PTP was also found to
CC   dephosphorylate PDGF beta receptor, and may be involved in
CC   UV-induced signal transduction.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1337)
CC   GPRFLN|  AUTHORS   Ruivenkamp,C.A., van Wezel,T., Zanon,C., Stassen,A.P., Vlcek,C.,
CC   GPRFLN|            Csikos,T., Klous,A.M., Tripodis,N., Perrakis,A., Boerrigter,L.,
CC   GPRFLN|            Groot,P.C., Lindeman,J., Mooi,W.J., Meijjer,G.A., Scholten,G.,
CC   GPRFLN|            Dauwerse,H., Paces,V., van Zandwijk,N., van Ommen,G.J. and
CC   GPRFLN|            Demant,P.
CC   GPRFLN|  TITLE     Ptprj is a candidate for the mouse colon-cancer susceptibility
CC   GPRFLN|            locus Scc1 and is frequently deleted in human cancers
CC   GPRFLN|  JOURNAL   Nat. Genet. 31 (3), 295-300 (2002)
CC   GPRFLN|  MEDLINE   22084388
CC   GPRFLN|  REMARK    GeneRIF: This protein is frequently deleted in human breast
CC   GPRFLN|            cancers.
CC   GPRFLN|REFERENCE   2  (residues 1 to 1337)
CC   GPRFLN|  AUTHORS   Baker,J.E., Majeti,R., Tangye,S.G. and Weiss,A.
CC   GPRFLN|  TITLE     Protein tyrosine phosphatase CD148-mediated inhibition of T-cell
CC   GPRFLN|            receptor signal transduction is associated with reduced LAT and
CC   GPRFLN|            phospholipase Cgamma1 phosphorylation
CC   GPRFLN|  JOURNAL   Mol. Cell. Biol. 21 (7), 2393-2403 (2001)
CC   GPRFLN|  MEDLINE   21160271
CC   GPRFLN|REFERENCE   3  (residues 1 to 1337)
CC   GPRFLN|  AUTHORS   Kovalenko,M., Denner,K., Sandstrom,J., Persson,C., Gross,S.,
CC   GPRFLN|            Jandt,E., Vilella,R., Bohmer,F. and Ostman,A.
CC   GPRFLN|  TITLE     Site-selective dephosphorylation of the platelet-derived growth
CC   GPRFLN|            factor beta-receptor by the receptor-like protein-tyrosine
CC   GPRFLN|            phosphatase DEP-1
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 275 (21), 16219-16226 (2000)
CC   GPRFLN|  MEDLINE   20283660
CC   GPRFLN|REFERENCE   4  (residues 1 to 1337)
CC   GPRFLN|  AUTHORS   Gross,S., Knebel,A., Tenev,T., Neininger,A., Gaestel,M.,
CC   GPRFLN|            Herrlich,P. and Bohmer,F.D.
CC   GPRFLN|  TITLE     Inactivation of protein-tyrosine phosphatases as mechanism of
CC   GPRFLN|            UV-induced signal transduction
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 274 (37), 26378-26386 (1999)
CC   GPRFLN|  MEDLINE   99403084
CC   GPRFLN|REFERENCE   5  (residues 1 to 1337)
CC   GPRFLN|  AUTHORS   Tangye,S.G., Phillips,J.H., Lanier,L.L., de Vries,J.E. and
CC   GPRFLN|            Aversa,G.
CC   GPRFLN|  TITLE     CD148: a receptor-type protein tyrosine phosphatase involved in the
CC   GPRFLN|            regulation of human T cell activation
CC   GPRFLN|  JOURNAL   J. Immunol. 161 (7), 3249-3255 (1998)
CC   GPRFLN|  MEDLINE   98430639
CC   GPRFLN|REFERENCE   6  (residues 1 to 1337)
CC   GPRFLN|  AUTHORS   de la Fuente-Garcia,M.A., Nicolas,J.M., Freed,J.H., Palou,E.,
CC   GPRFLN|            Thomas,A.P., Vilella,R., Vives,J. and Gaya,A.
CC   GPRFLN|  TITLE     CD148 is a membrane protein tyrosine phosphatase present in all
CC   GPRFLN|            hematopoietic lineages and is involved in signal transduction on
CC   GPRFLN|            lymphocytes
CC   GPRFLN|  JOURNAL   Blood 91 (8), 2800-2809 (1998)
CC   GPRFLN|  MEDLINE   98200586
CC   GPRFLN|REFERENCE   7  (residues 1 to 1337)
CC   GPRFLN|  AUTHORS   Honda,H., Inazawa,J., Nishida,J., Yazaki,Y. and Hirai,H.
CC   GPRFLN|  TITLE     Molecular cloning, characterization, and chromosomal localization
CC   GPRFLN|            of a novel protein-tyrosine phosphatase, HPTP eta
CC   GPRFLN|  JOURNAL   Blood 84 (12), 4186-4194 (1994)
CC   GPRFLN|  MEDLINE   95086212
CC   GPRFLN|REFERENCE   8  (residues 1 to 1337)
CC   GPRFLN|  AUTHORS   Ostman,A., Yang,Q. and Tonks,N.K.
CC   GPRFLN|  TITLE     Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase,
CC   GPRFLN|            is enhanced with increasing cell density
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 91 (21), 9680-9684 (1994)
CC   GPRFLN|  MEDLINE   95024024
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    277       VNTIFKEY:269
FT   PROTEIN       1    277       protein tyrosine phosphatase, receptor type, J polypeptide; human density enhanced phosphatase-1; CD148 antigen
FT                                VNTIFKEY:270
FT   CHAIN         1    277       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       17    277       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   277 AA;
     ENFEAYFKKQ QADSNCGFAE EYEDLKLVGI SQPKYAAELA ENRGKNRYNN VLPYDISRVK        60
     LSVQTHSTDD YINANYMPGY HSKKDFIATQ GPLPNTLKDF WRMVWEKNVY AIIMLTKCVE       120
     QGRTKCEEYW PSKQAQDYGD ITVAMTSEIV LPEWTIRDFT VKNIQTSESH PLRQFHFTSW       180
     PDHGVPDTTD LLINFRYLVR DYMKQSPPES PILVHCSAGV GRTGTFIAID RLIYQIENEN       240
     TVDVYGIVYD LRMHRPLMVQ TEDQYVFLNQ CVLDIVR                                277
//
ID   hGLEPP1_D1\(NP_109592)\PTPRO STANDARD;PRT;   277 AA.
AC   NP_109592;
DT   27-JUN-2003
DE   receptor-type protein tyrosine phosphatase O isoform a precursor; glomerular epithelial protein-1; protein tyrosine phosphatase PTP-U2; phosphotyrosine phosphatase U2; PTPase U2; PTPROt [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from Z48541.1 and U20489.1.
CC   
CC   Summary: This gene encodes a receptor-type protein tyrosine
CC   phosphatase containing a single intracellular catalytic domain with
CC   a characteristic signature motif. The gene product, which has a
CC   transmembrane domain, is an integral membrane protein. Several
CC   alternatively spliced transcript variants, some of which encode
CC   different isoforms of the protein, have been described. These
CC   variants exhibit tissue-specific expression.
CC   
CC   Transcript Variant: This variant (1) encodes the longest isoform
CC   (a) known to date. The encoded protein has a large extracellular
CC   domain containing 8 repeats of a fibronectin type III-like motif.
CC   This variant is expressed in the glomerulus of kidney and in brain.
CC   In kidney, it may play a role in regulating glomerular epithelial
CC   cell (podocyte) structure and/or function.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1216)
CC   GPRFLN|  AUTHORS   Aguiar,R.C., Yakushijin,Y., Kharbanda,S., Tiwari,S., Freeman,G.J.
CC   GPRFLN|            and Shipp,M.A.
CC   GPRFLN|  TITLE     PTPROt: an alternatively spliced and developmentally regulated
CC   GPRFLN|            B-lymphoid phosphatase that promotes G0/G1 arrest
CC   GPRFLN|  JOURNAL   Blood 94 (7), 2403-2413 (1999)
CC   GPRFLN|  MEDLINE   99428326
CC   GPRFLN|REFERENCE   2  (residues 1 to 1216)
CC   GPRFLN|  AUTHORS   Seimiya,H., Sawabe,T., Inazawa,J. and Tsuruo,T.
CC   GPRFLN|  TITLE     Cloning, expression and chromosomal localization of a novel gene
CC   GPRFLN|            for protein tyrosine phosphatase (PTP-U2) induced by various
CC   GPRFLN|            differentiation-inducing agents
CC   GPRFLN|  JOURNAL   Oncogene 10 (9), 1731-1738 (1995)
CC   GPRFLN|  MEDLINE   95273089
CC   GPRFLN|REFERENCE   3  (residues 1 to 1216)
CC   GPRFLN|  AUTHORS   Wiggins,R.C., Wiggins,J.E., Goyal,M., Wharram,B.L. and Thomas,P.E.
CC   GPRFLN|  TITLE     Molecular cloning of cDNAs encoding human GLEPP1, a membrane
CC   GPRFLN|            protein tyrosine phosphatase: characterization of the GLEPP1
CC   GPRFLN|            protein distribution in human kidney and assignment of the GLEPP1
CC   GPRFLN|            gene to human chromosome 12p12-p13
CC   GPRFLN|  JOURNAL   Genomics 27 (1), 174-181 (1995)
CC   GPRFLN|  MEDLINE   95394455
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|JNA|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   REGION       17    272       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_2
FT   DOMAIN      214    224       VNTIFKEY:1000; VNTINAME:Dom_Misc_3
SQ   SEQUENCE   277 AA;
     DDFDAYIKDM AKDSDYKFSL QFEELKLIGL DIPHFAADLP LNRCKNRYTN ILPYDFSRVR        60
     LVSMNEEEGA DYINANYIPG YNSPQEYIAT QGPLPETRND FWKMVLQQKS QIIVMLTQCN       120
     EKRRVKCDHY WPFTEEPIAY GDITVEMISE EEQDDWACRH FRINYADEMQ DVMHFNYTAW       180
     PDHGVPTANA AESILQFVHM VRQQATKSKG PMIIHCSAGV GRTGTFIALD RLLQHIRDHE       240
     FVDILGLVSE MRSYRMSMVQ TEEQYIFIHQ CVQLMWM                                277
//
ID   hHDPTP_D1\(NP_056281)\PTPN23 STANDARD;PRT;   286 AA.
AC   NP_056281;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, non-receptor type 23; His-domain protein tyrosine phosphatase [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   PREDICTED REFSEQ: The mRNA record is supported by experimental
CC   evidence; however, the coding sequence is predicted. The reference
CC   sequence was derived from AF290614.1.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1636)
CC   GPRFLN|  AUTHORS   Qu,X., Zhai,Y., Wei,H., Zhang,C., Xing,G., Lu,C., Wang,M. and He,F.
CC   GPRFLN|  TITLE     Cloning, chromosomal assignment and tissue expression of a novel
CC   GPRFLN|            human protein tyrosine phosphatase (PTP-TD14) gene
CC   GPRFLN|  JOURNAL   I Chuan 23 (6), 1-9 (2001)
CC   GPRFLN|REFERENCE   2  (residues 1 to 1636)
CC   GPRFLN|  AUTHORS   Toyooka,S., Ouchida,M., Jitsumori,Y., Tsukuda,K., Sakai,A.,
CC   GPRFLN|            Nakamura,A., Shimizu,N. and Shimizu,K.
CC   GPRFLN|  TITLE     HD-PTP: A novel protein tyrosine phosphatase gene on human
CC   GPRFLN|            chromosome 3p21.3
CC   GPRFLN|  JOURNAL   Biochem. Biophys. Res. Commun. 278 (3), 671-678 (2000)
CC   GPRFLN|  MEDLINE   20549011
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    286       VNTIFKEY:269
FT   PROTEIN       1    286       His-domain protein tyrosine phosphatase
FT                                VNTIFKEY:270
FT   REGION       23    286       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_2
SQ   SEQUENCE   286 AA;
     ERLRQLQQEL EAFRGQLGDV GALDTVWREL QDAQEHDARG RSIAIARCYS LKNRHQDVMP        60
     YDSNRVVLRS GKDDYINASC VEGLSPYCPP LVATQAPLPG TAADFWLMVH EQKVSVIVML       120
     VSEAEMEKQK VARYFPTERG QPMVHGALSL ALSSVRSTET HVERVLSLQF RDQSLKRSLV       180
     HLHFPTWPEL GLPDSPSNLL RFIQEVHAHY LHQRPLHTPI IVHCSSGVGR TGAFALLYAA       240
     VQEVEAGNGI PELPQLVRRM RQQRKHMLQE KLHLRFCYEA VVRHVE                      286
//
ID   hHePTP_D1\(NP_002823)\PTPN7 STANDARD;PRT;   273 AA.
AC   NP_002823;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, non-receptor type 7 isoform 1; protein-tyrosine phoshatase, nonreceptor-type, stress induced; hematopoietic protein-tyrosine phosphatase [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from BC001746.1, BG340453.1,
CC   D11327.1 and M64322.1.
CC   On Jan 25, 2002 this sequence version replaced gi:4506299.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This gene is preferentially expressed in
CC   a variety of hematopoietic cells, and is an early response gene in
CC   lymphokine stimulated cells. The noncatalytic N-terminus of this
CC   PTP can interact with MAP kinases and suppress the MAP kinase
CC   activities. This PTP was shown to be involved in the regulation of
CC   T cell antigen receptor (TCR) signaling, which was thought to
CC   function through dephosphorylating the molecules related to MAP
CC   kinase pathway. Three alternatively spliced transcript variants of
CC   this gene, which encode two distinct isoforms, are reported.
CC   
CC   Transcript Variant: This variant (1) contains a different 5'
CC   region, which includes a part of the coding sequence when compared
CC   to variant 2. It thus encodes a protein that has a shorter
CC   N-terminus, as compared to isoform 2.
CC   GPRFLN|REFERENCE   1  (residues 1 to 360)
CC   GPRFLN|  AUTHORS   Oh-hora,M., Ogata,M., Mori,Y., Adachi,M., Imai,K., Kosugi,A. and
CC   GPRFLN|            Hamaoka,T.
CC   GPRFLN|  TITLE     Direct suppression of TCR-mediated activation of extracellular
CC   GPRFLN|            signal-regulated kinase by leukocyte protein tyrosine phosphatase,
CC   GPRFLN|            a tyrosine-specific phosphatase
CC   GPRFLN|  JOURNAL   J. Immunol. 163 (3), 1282-1288 (1999)
CC   GPRFLN|  MEDLINE   99343735
CC   GPRFLN|REFERENCE   2  (residues 1 to 360)
CC   GPRFLN|  AUTHORS   Saxena,M., Williams,S., Brockdorff,J., Gilman,J. and Mustelin,T.
CC   GPRFLN|  TITLE     Inhibition of T cell signaling by mitogen-activated protein
CC   GPRFLN|            kinase-targeted hematopoietic tyrosine phosphatase (HePTP)
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 274 (17), 11693-11700 (1999)
CC   GPRFLN|  MEDLINE   99223488
CC   GPRFLN|REFERENCE   3  (residues 1 to 360)
CC   GPRFLN|  AUTHORS   Saxena,M., Williams,S., Gilman,J. and Mustelin,T.
CC   GPRFLN|  TITLE     Negative regulation of T cell antigen receptor signal transduction
CC   GPRFLN|            by hematopoietic tyrosine phosphatase (HePTP)
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 273 (25), 15340-15344 (1998)
CC   GPRFLN|  MEDLINE   98288260
CC   GPRFLN|REFERENCE   4  (residues 1 to 360)
CC   GPRFLN|  AUTHORS   Swieter,M., Berenstein,E.H., Swaim,W.D. and Siraganian,R.P.
CC   GPRFLN|  TITLE     Aggregation of IgE receptors in rat basophilic leukemia 2H3 cells
CC   GPRFLN|            induces tyrosine phosphorylation of the cytosolic protein-tyrosine
CC   GPRFLN|            phosphatase HePTP
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 270 (37), 21902-21906 (1995)
CC   GPRFLN|  MEDLINE   95394959
CC   GPRFLN|REFERENCE   5  (residues 1 to 360)
CC   GPRFLN|  AUTHORS   Adachi,M., Sekiya,M., Isobe,M., Kumura,Y., Ogita,Z., Hinoda,Y.,
CC   GPRFLN|            Imai,K. and Yachi,A.
CC   GPRFLN|  TITLE     Molecular cloning and chromosomal mapping of a human
CC   GPRFLN|            protein-tyrosine phosphatase LC-PTP
CC   GPRFLN|  JOURNAL   Biochem. Biophys. Res. Commun. 186 (3), 1607-1615 (1992)
CC   GPRFLN|  MEDLINE   92378634
CC   GPRFLN|REFERENCE   6  (residues 1 to 360)
CC   GPRFLN|  AUTHORS   Adachi,M., Sekiya,M., Arimura,Y., Takekawa,M., Itoh,F., Hinoda,Y.,
CC   GPRFLN|            Imai,K. and Yachi,A.
CC   GPRFLN|  TITLE     Protein-tyrosine phosphatase expression in pre-B cell NALM-6
CC   GPRFLN|  JOURNAL   Cancer Res. 52 (3), 737-740 (1992)
CC   GPRFLN|  MEDLINE   92119637
CC   GPRFLN|REFERENCE   7  (sites)
CC   GPRFLN|  AUTHORS   Zanke,B., Suzuki,H., Kishihara,K., Mizzen,L., Minden,M., Pawson,A.
CC   GPRFLN|            and Mak,T.W.
CC   GPRFLN|  TITLE     Cloning and expression of an inducible lymphoid-specific, protein
CC   GPRFLN|            tyrosine phosphatase (HePTPase)
CC   GPRFLN|  JOURNAL   Eur. J. Immunol. 22 (1), 235-239 (1992)
CC   GPRFLN|  MEDLINE   92111631
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    273       VNTIFKEY:269
FT   PROTEIN       1    273       protein-tyrosine phoshatase, nonreceptor-type, stress induced; hematopoietic protein-tyrosine phosphatase
FT                                VNTIFKEY:270
FT   REGION       17    271       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   273 AA;
     HPLTRWALQR QPPSPKQLEE EFLKIPSNFV SPEDLDIPGH ASKDRYKTIL PNPQSRVCLG        60
     RAQSQEDGDY INANYIRGYD GKEKVYIATQ GPMPNTVSDF WEMVWQEEVS LIVMLTQLRE       120
     GKEKCVHYWP TEEETYGPFQ IRIQDMKECP EYTVRQLTIQ YQEERRSVKH ILFSAWPDHQ       180
     TPESAGPLLR LVAEVEESPE TAAHPGPIVV HCSAGIGRTG CFIATRIGCQ QLKARGEVDI       240
     LGIVCQLRLD RGGMIQTAEQ YQFLHHTLAL YAG                                    273
//
ID   hIA2_D1\(NP_002837)\PTPRN STANDARD;PRT;   279 AA.
AC   NP_002837;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, N precursor; islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N precursor [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from L18983.1, AF042285.4 and
CC   BC007713.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP possesses an extracellular
CC   region, a single transmembrane region, and a single catalytic
CC   domain, and thus represents a receptor-type PTP. This PTP was found
CC   to be an autoantigen that is reactive with insulin-dependent
CC   diabetes mellitus (IDDM) patient sera, and thus may be a potential
CC   target of autoimmunity in diabetes mellitus.
CC   GPRFLN|REFERENCE   1  (residues 1 to 979)
CC   GPRFLN|  AUTHORS   Sanjeevi,C.B., Das,A.K. and Shtauvere-Brameus,A.
CC   GPRFLN|  TITLE     BCG vaccination and GAD65 and IA-2 autoantibodies in autoimmune
CC   GPRFLN|            diabetes in southern India
CC   GPRFLN|  JOURNAL   Ann. N. Y. Acad. Sci. 958, 293-296 (2002)
CC   GPRFLN|  MEDLINE   22015049
CC   GPRFLN|  REMARK    GeneRIF: BCG vaccination and GAD65 and IA-2 autoantibodies in
CC   GPRFLN|            autoimmune diabetes in southern India.
CC   GPRFLN|REFERENCE   2  (residues 1 to 979)
CC   GPRFLN|  AUTHORS   Kawasaki,E., Yamaguchi,H., Hattori,H., Egashira,T. and Eguchi,K.
CC   GPRFLN|  TITLE     Autoantibodies to IA-2 in type 1 diabetes: measurements with a new
CC   GPRFLN|            enzyme-linked immunosorbent assay
CC   GPRFLN|  JOURNAL   Ann. N. Y. Acad. Sci. 958, 241-246 (2002)
CC   GPRFLN|  MEDLINE   22015037
CC   GPRFLN|  REMARK    GeneRIF: Autoantibodies to IA-2 in type 1 diabetes: measurements
CC   GPRFLN|            with a new enzyme-linked immunosorbent assay.
CC   GPRFLN|REFERENCE   3  (residues 1 to 979)
CC   GPRFLN|  AUTHORS   Miao,D., Yu,L., Tiberti,C., Cuthbertson,D.D., Rewers,M., di
CC   GPRFLN|            Mario,U., Eisenbarth,G.S. and Dotta,F.
CC   GPRFLN|  TITLE     ICA512(IA-2) epitope specific assays distinguish transient from
CC   GPRFLN|            diabetes associated autoantibodies
CC   GPRFLN|  JOURNAL   J. Autoimmun. 18 (2), 191-196 (2002)
CC   GPRFLN|  MEDLINE   21906940
CC   GPRFLN|  REMARK    GeneRIF: ICA512(IA-2) epitope specific assays distinguish transient
CC   GPRFLN|            from diabetes associated autoantibodies.
CC   GPRFLN|REFERENCE   4  (residues 1 to 979)
CC   GPRFLN|  AUTHORS   Mikulecky,M. and Michalkova,D.
CC   GPRFLN|  TITLE     Secular and seasonal cycling of IA2-ab autoantibody in Slovak
CC   GPRFLN|            diabetic children
CC   GPRFLN|  JOURNAL   Biomed. Pharmacother. 55 Suppl 1, 106S-109S (2001)
CC   GPRFLN|  MEDLINE   21630621
CC   GPRFLN|REFERENCE   5  (residues 1 to 979)
CC   GPRFLN|  AUTHORS   Cui,L., Yu,W.P., DeAizpurua,H.J., Schmidli,R.S. and Pallen,C.J.
CC   GPRFLN|  TITLE     Cloning and characterization of islet cell antigen-related
CC   GPRFLN|            protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and
CC   GPRFLN|            autoantigen in insulin-dependent diabetes
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 271 (40), 24817-24823 (1996)
CC   GPRFLN|  MEDLINE   96394649
CC   GPRFLN|REFERENCE   6  (residues 1 to 979)
CC   GPRFLN|  AUTHORS   van den Maagdenberg,A.M., Olde Weghuis,D., Rijss,J., van de
CC   GPRFLN|            Wetering,R.A., Wieringa,B., Geurts van Kessel,A. and Hendriks,W.J.
CC   GPRFLN|  TITLE     Assignment of the human gene for receptor-type protein tyrosine
CC   GPRFLN|            phosphatase IA-2 (PTPRN) to chromosome region 2q35 --> q36.1 and
CC   GPRFLN|            identification of an intragenic genetic marker
CC   GPRFLN|  JOURNAL   Cytogenet. Cell Genet. 73 (1-2), 145-148 (1996)
CC   GPRFLN|  MEDLINE   96244610
CC   GPRFLN|REFERENCE   7  (residues 1 to 979)
CC   GPRFLN|  AUTHORS   Lan,M.S., Lu,J., Goto,Y. and Notkins,A.L.
CC   GPRFLN|  TITLE     Molecular cloning and identification of a receptor-type protein
CC   GPRFLN|            tyrosine phosphatase, IA-2, from human insulinoma
CC   GPRFLN|  JOURNAL   DNA Cell Biol. 13 (5), 505-514 (1994)
CC   GPRFLN|  MEDLINE   94296553
CC   GPRFLN|REFERENCE   8  (residues 1 to 979)
CC   GPRFLN|  AUTHORS   Rabin,D.U., Pleasic,S.M., Shapiro,J.A., Yoo-Warren,H., Oles,J.,
CC   GPRFLN|            Hicks,J.M., Goldstein,D.E. and Rae,P.M.
CC   GPRFLN|  TITLE     Islet cell antigen 512 is a diabetes-specific islet autoantigen
CC   GPRFLN|            related to protein tyrosine phosphatases
CC   GPRFLN|  JOURNAL   J. Immunol. 152 (6), 3183-3188 (1994)
CC   GPRFLN|  MEDLINE   94194080
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    279       VNTIFKEY:269
FT   PROTEIN       1    279       islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N precursor
FT                                VNTIFKEY:270
FT   CHAIN         1    279       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       17    278       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   279 AA;
     HMILAYMEDH LRNRDRLAKE WQALCAYQAE PNTCATAQGE GNIKKNRHPD FLPYDHARIK        60
     LKVESSPSRS DYINASPIIE HDPRMPAYIA TQGPLSHTIA DFWQMVWESG CTVIVMLTPL       120
     VEDGVKQCDR YWPDEGASLY HVYEVNLVSE HIWCEDFLVR SFYLKNVQTQ ETRTLTQFHF       180
     LSWPAEGTPA STRPLLDFRR KVNKCYRGRS CPIIVHCSDG AGRTGTYILI DMVLNRMAKG       240
     VKEIDIAATL EHVRDQRPGL VRSKDQFEFA LTAVAEEVN                              279
//
ID   hIA2beta_D1\(NP_002838)\PTPRN2 STANDARD;PRT;   279 AA.
AC   NP_002838;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, N polypeptide 2 isoform 1 precursor; protein tyrosine phosphatase receptor pi; phogrin; tyrosine phosphatase IA-2 beta; IAR/receptor-like protein-tyrosine phosphatase [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from U66702.1 and AF007555.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP possesses an extracellular
CC   region, a single transmembrane region, and a single intracellular
CC   catalytic domain, and thus represents a receptor-type PTP. The
CC   catalytic domain of this PTP is most closely related to
CC   PTPRN/IA-2beta. This PTP and PTPRN are both found to be major
CC   autoantigens associated with insulin-dependent diabetes mellitus.
CC   Three alternatively spliced transcript variants of this gene, which
CC   encode distinct proteins, have been reported.
CC   
CC   Transcript Variant: This variant (1) encodes the longest isoform
CC   (1).
CC   GPRFLN|REFERENCE   1  (residues 1 to 1015)
CC   GPRFLN|  AUTHORS   van den Maagdenberg,A.M., Schepens,J.T., Schepens,M.T., Pepers,B.,
CC   GPRFLN|            Wieringa,B., van Kessel,A.G. and Hendriks,W.J.
CC   GPRFLN|  TITLE     Assignment of Ptprn2, the gene encoding receptor-type protein
CC   GPRFLN|            tyrosine phosphatase IA-2beta, a major autoantigen in
CC   GPRFLN|            insulin-dependent diabetes mellitus, to mouse chromosome region 12F
CC   GPRFLN|  JOURNAL   Cytogenet. Cell Genet. 82 (3-4), 153-155 (1998)
CC   GPRFLN|  MEDLINE   99077744
CC   GPRFLN|REFERENCE   2  (residues 1 to 1015)
CC   GPRFLN|  AUTHORS   Schmidli,R.S., Colman,P.G., Cui,L., Yu,W.P., Kewming,K.,
CC   GPRFLN|            Jankulovski,C., Harrison,L.C., Pallen,C.J. and DeAizpurua,H.J.
CC   GPRFLN|  TITLE     Antibodies to the protein tyrosine phosphatases IAR and IA-2 are
CC   GPRFLN|            associated with progression to insulin-dependent diabetes (IDDM) in
CC   GPRFLN|            first-degree relatives at-risk for IDDM
CC   GPRFLN|  JOURNAL   Autoimmunity 28 (1), 15-23 (1998)
CC   GPRFLN|  MEDLINE   98425805
CC   GPRFLN|REFERENCE   3  (residues 1 to 1015)
CC   GPRFLN|  AUTHORS   Li,Q., Borovitskaya,A.E., DeSilva,M.G., Wasserfall,C.,
CC   GPRFLN|            Maclaren,N.K., Notkins,A.L. and Lan,M.S.
CC   GPRFLN|  TITLE     Autoantigens in insulin-dependent diabetes mellitus: molecular
CC   GPRFLN|            cloning and characterization of human IA-2 beta
CC   GPRFLN|  JOURNAL   Proc. Assoc. Am. Physicians 109 (4), 429-439 (1997)
CC   GPRFLN|  MEDLINE   97364262
CC   GPRFLN|REFERENCE   4  (residues 1 to 1015)
CC   GPRFLN|  AUTHORS   Smith,P.D., Barker,K.T., Wang,J., Lu,Y.J., Shipley,J. and
CC   GPRFLN|            Crompton,M.R.
CC   GPRFLN|  TITLE     ICAAR, a novel member of a new family of transmembrane, tyrosine
CC   GPRFLN|            phosphatase-like proteins
CC   GPRFLN|  JOURNAL   Biochem. Biophys. Res. Commun. 229 (2), 402-411 (1996)
CC   GPRFLN|  MEDLINE   97127415
CC   GPRFLN|REFERENCE   5  (residues 1 to 1015)
CC   GPRFLN|  AUTHORS   Kawasaki,E., Hutton,J.C. and Eisenbarth,G.S.
CC   GPRFLN|  TITLE     Molecular cloning and characterization of the human transmembrane
CC   GPRFLN|            protein tyrosine phosphatase homologue, phogrin, an autoantigen of
CC   GPRFLN|            type 1 diabetes
CC   GPRFLN|  JOURNAL   Biochem. Biophys. Res. Commun. 227 (2), 440-447 (1996)
CC   GPRFLN|  MEDLINE   97032784
CC   GPRFLN|REFERENCE   6  (residues 1 to 1015)
CC   GPRFLN|  AUTHORS   Cui,L., Yu,W.P., DeAizpurua,H.J., Schmidli,R.S. and Pallen,C.J.
CC   GPRFLN|  TITLE     Cloning and characterization of islet cell antigen-related
CC   GPRFLN|            protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and
CC   GPRFLN|            autoantigen in insulin-dependent diabetes
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 271 (40), 24817-24823 (1996)
CC   GPRFLN|  MEDLINE   96394649
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    279       VNTIFKEY:269
FT   PROTEIN       1    279       protein tyrosine phosphatase receptor pi; phogrin; tyrosine phosphatase IA-2 beta; IAR/receptor-like protein-tyrosine phosphatase
FT                                VNTIFKEY:270
FT   CHAIN         1    279       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       17    278       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   279 AA;
     HMILSYMEDH LKNKNRLEKE WEALCAYQAE PNSSFVAQRE ENVPKNRSLA VLTYDHSRVL        60
     LKAENSHSHS DYINASPIMD HDPRNPAYIA TQGPLPATVA DFWQMVWESG CVVIVMLTPL       120
     AENGVRQCYH YWPDEGSNLY HIYEVNLVSE HIWCEDFLVR SFYLKNLQTN ETRTVTQFHF       180
     LSWYDRGVPS SSRSLLDFRR KVNKCYRGRS CPIIVHCSDG AGRSGTYVLI DMVLNKMAKG       240
     AKEIDIAATL EHLRDQRPGM VQTKEQFEFA LTAVAEEVN                              279
//
ID   hLAR_D1\(NP_002831)\PTPRF STANDARD;PRT;   275 AA.
AC   NP_002831;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, F isoform 1 precursor; protein tyrosine phosphatase, receptor type, F polypeptide; receptor-linked protein-tyrosine phosphatase LAR; leukocyte antigen-related tyrosine phosphatase; LCA-homolog [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from Y00815.1 and BI711143.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP possesses an extracellular
CC   region, a single transmembrane region, and two tandem
CC   intracytoplasmic catalytic domains, and thus represents a
CC   receptor-type PTP. The extracellular region contains three Ig-like
CC   domains, and nine non-Ig like domains similar to that of
CC   neural-cell adhesion molecule. This PTP was shown to function in
CC   the regulation of epithelial cell-cell contacts at adherents
CC   junctions, as well as in the control of beta-catenin signaling. An
CC   increased expression level of this protein was found in the
CC   insulin-responsive tissue of obese, insulin-resistant individuals,
CC   and may contribute to the pathogenesis of insulin resistance. Two
CC   alternatively spliced transcript variants of this gene, which
CC   encode distinct proteins, have been reported.
CC   
CC   Transcript Variant: This variant (1) contains an extra internal
CC   fragment within the coding region when compared to variant 2. It
CC   thus encodes a protein that has a 9 aa internal fragment absent in
CC   isoform 2.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1897)
CC   GPRFLN|  AUTHORS   Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J.
CC   GPRFLN|  TITLE     Intra- and intermolecular interactions between intracellular
CC   GPRFLN|            domains of receptor protein-tyrosine phosphatases
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (49), 47263-47269 (2002)
CC   GPRFLN|  MEDLINE   22344739
CC   GPRFLN|  REMARK    GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are
CC   GPRFLN|            a common but specific mechanism that is likely to be regulated-
CC   GPRFLN|            domain2s and the wedge structures are crucial determinants of
CC   GPRFLN|            binding specificity, thus regulating cross-talk between RPTPs
CC   GPRFLN|REFERENCE   2  (residues 1 to 1897)
CC   GPRFLN|  AUTHORS   Symons,J.R., LeVea,C.M. and Mooney,R.A.
CC   GPRFLN|  TITLE     Expression of the leucocyte common antigen-related (LAR) tyrosine
CC   GPRFLN|            phosphatase is regulated by cell density through functional
CC   GPRFLN|            E-cadherin complexes
CC   GPRFLN|  JOURNAL   Biochem. J. 365 (Pt 2), 513-519 (2002)
CC   GPRFLN|  MEDLINE   22090243
CC   GPRFLN|  REMARK    GeneRIF: regulation of expression by cell density through
CC   GPRFLN|            functional E-cadherin complexes
CC   GPRFLN|REFERENCE   3  (residues 1 to 1897)
CC   GPRFLN|  AUTHORS   Zabolotny,J.M., Kim,Y.B., Peroni,O.D., Kim,J.K., Pani,M.A.,
CC   GPRFLN|            Boss,O., Klaman,L.D., Kamatkar,S., Shulman,G.I., Kahn,B.B. and
CC   GPRFLN|            Neel,B.G.
CC   GPRFLN|  TITLE     Overexpression of the LAR (leukocyte antigen-related)
CC   GPRFLN|            protein-tyrosine phosphatase in muscle causes insulin resistance
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 98 (9), 5187-5192 (2001)
CC   GPRFLN|  MEDLINE   21221100
CC   GPRFLN|REFERENCE   4  (residues 1 to 1897)
CC   GPRFLN|  AUTHORS   Muller,T., Choidas,A., Reichmann,E. and Ullrich,A.
CC   GPRFLN|  TITLE     Phosphorylation and free pool of beta-catenin are regulated by
CC   GPRFLN|            tyrosine kinases and tyrosine phosphatases during epithelial cell
CC   GPRFLN|            migration
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 274 (15), 10173-10183 (1999)
CC   GPRFLN|  MEDLINE   99214576
CC   GPRFLN|REFERENCE   5  (residues 1 to 1897)
CC   GPRFLN|  AUTHORS   Ahmad,F. and Goldstein,B.J.
CC   GPRFLN|  TITLE     Functional association between the insulin receptor and the
CC   GPRFLN|            transmembrane protein-tyrosine phosphatase LAR in intact cells
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 272 (1), 448-457 (1997)
CC   GPRFLN|  MEDLINE   97150746
CC   GPRFLN|REFERENCE   6  (residues 1 to 1897)
CC   GPRFLN|  AUTHORS   Harder,K.W., Saw,J., Miki,N. and Jirik,F.
CC   GPRFLN|  TITLE     Coexisting amplifications of the chromosome 1p32 genes (PTPRF and
CC   GPRFLN|            MYCL1) encoding protein tyrosine phosphatase LAR and L-myc in a
CC   GPRFLN|            small cell lung cancer line
CC   GPRFLN|  JOURNAL   Genomics 27 (3), 552-553 (1995)
CC   GPRFLN|  MEDLINE   96047346
CC   GPRFLN|REFERENCE   7  (residues 1 to 1897)
CC   GPRFLN|  AUTHORS   Schaapveld,R.Q., van den Maagdenberg,A.M., Schepens,J.T.,
CC   GPRFLN|            Weghuis,D.O., Geurts van Kessel,A., Wieringa,B. and Hendriks,W.J.
CC   GPRFLN|  TITLE     The mouse gene Ptprf encoding the leukocyte common antigen-related
CC   GPRFLN|            molecule LAR: cloning, characterization, and chromosomal
CC   GPRFLN|            localization
CC   GPRFLN|  JOURNAL   Genomics 27 (1), 124-130 (1995)
CC   GPRFLN|  MEDLINE   95394448
CC   GPRFLN|REFERENCE   8  (residues 1 to 1897)
CC   GPRFLN|  AUTHORS   O'Grady,P., Krueger,N.X., Streuli,M. and Saito,H.
CC   GPRFLN|  TITLE     Genomic organization of the human LAR protein tyrosine phosphatase
CC   GPRFLN|            gene and alternative splicing in the extracellular fibronectin
CC   GPRFLN|            type-III domains
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 269 (40), 25193-25199 (1994)
CC   GPRFLN|  MEDLINE   95014301
CC   GPRFLN|REFERENCE   9  (residues 1 to 1897)
CC   GPRFLN|  AUTHORS   Streuli,M., Krueger,N.X., Hall,L.R., Schlossman,S.F. and Saito,H.
CC   GPRFLN|  TITLE     A new member of the immunoglobulin superfamily that has a
CC   GPRFLN|            cytoplasmic region homologous to the leukocyte common antigen
CC   GPRFLN|  JOURNAL   J. Exp. Med. 168 (5), 1523-1530 (1988)
CC   GPRFLN|  MEDLINE   89035978
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    275       VNTIFKEY:269
FT   PROTEIN       1    275       protein tyrosine phosphatase, receptor type, F polypeptide; receptor-linked protein-tyrosine phosphatase LAR; leukocyte antigen-related tyrosine phosphatase; LCA-homolog
FT                                VNTIFKEY:270
FT   CHAIN         1    275       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       17    272       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_4
SQ   SEQUENCE   275 AA;
     TDLADNIERL KANDGLKFSQ EYESIDPGQQ FTWENSNLEV NKPKNRYANV IAYDHSRVIL        60
     TSIDGVPGSD YINANYIDGY RKQNAYIATQ GPLPETMGDF WRMVWEQRTA TVVMMTRLEE       120
     KSRVKCDQYW PARGTETCGL IQVTLLDTVE LATYTVRTFA LHKSGSSEKR ELRQFQFMAW       180
     PDHGVPEYPT PILAFLRRVK ACNPLDAGPM VVHCSAGVGR TGCFIVIDAM LERMKHEKTV       240
     DIYGHVTCMR SQRNYMVQTE DQYVFIHEAL LEAAT                                  275
//
ID   hLyPTP_D1\(NP_057051)\PTPN22 STANDARD;PRT;   287 AA.
AC   NP_057051;
DT   30-JUN-2003
DE   lymphoid-specific protein tyrosine phosphatase isoform 1; lymphoid-specific protein tyrosine phosphatase; protein tyrosine phosphatase homolog [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from AF077031.1 and AF001846.1.
CC   
CC   Summary: This gene encodes a protein tyrosine phosphatase which is
CC   expressed primarily in lymphoid tissues. This enzyme associates
CC   with the molecular adapter protein CBL and may be involved in
CC   regulating CBL function in the T-cell receptor signaling pathway.
CC   Alternative splicing of this gene results in two transcript
CC   variants encoding distinct isoforms.
CC   
CC   Transcript Variant: This variant (1) encodes the longer isoform (1)
CC   which is 116 aa longer than isoform 2 and has a distinct
CC   C-terminus.
CC   GPRFLN|REFERENCE   1  (residues 1 to 807)
CC   GPRFLN|  AUTHORS   Hill,R.J., Zozulya,S., Lu,Y.L., Ward,K., Gishizky,M. and Jallal,B.
CC   GPRFLN|  TITLE     The lymphoid protein tyrosine phosphatase Lyp interacts with the
CC   GPRFLN|            adaptor molecule Grb2 and functions as a negative regulator of
CC   GPRFLN|            T-cell activation
CC   GPRFLN|  JOURNAL   Exp. Hematol. 30 (3), 237-244 (2002)
CC   GPRFLN|  MEDLINE   21876996
CC   GPRFLN|  REMARK    GeneRIF: data demonstrate a novel interaction between Lyp and the
CC   GPRFLN|            adaptor Grb2 and are consistent with a negative regulatory role for
CC   GPRFLN|            Lyp in T-cell signaling.
CC   GPRFLN|REFERENCE   2  (residues 1 to 807)
CC   GPRFLN|  AUTHORS   Cohen,S., Dadi,H., Shaoul,E., Sharfe,N. and Roifman,C.M.
CC   GPRFLN|  TITLE     Cloning and characterization of a lymphoid-specific, inducible
CC   GPRFLN|            human protein tyrosine phosphatase, Lyp
CC   GPRFLN|  JOURNAL   Blood 93 (6), 2013-2024 (1999)
CC   GPRFLN|  MEDLINE   99168989
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|JNA|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    287       VNTIFKEY:269
FT   PROTEIN       1    287       lymphoid-specific protein tyrosine phosphatase; protein tyrosine phosphatase homolog
FT                                VNTIFKEY:270
FT   REGION       20    287       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   287 AA;
     EILQKFLDEA QSKKITKEEF ANEFLKLKRQ STKYKADKTY PTTVAEKPKN IKKNRYKDIL        60
     PYDYSRVELS LITSDEDSSY INANFIKGVY GPKAYIATQG PLSTTLLDFW RMIWEYSVLI       120
     IGMACMEYEM GKKKCERYWA EPVEMQLEFG PFSVSCEAEK RKSDYIIRTL KVKFNSETRT       180
     IYQFHYKNWP DHDVPSSIDP ILELIWDVRC YQEDDSVPIC IHCSAGCGRT GVICAIDYTW       240
     MLLKDGIIPE NFSVFSLIRE MRTQRPSLVQ TQEQYELVYN AVLELFK                     287
//
ID   hMEG1_D1\(NP_002821)\PTPN4 STANDARD;PRT;   277 AA.
AC   NP_002821;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, non-receptor type 4; megakaryocyte phosphatase; PTPase-MEG1; protein tyrosine phosphatase MEG1; megakaryocyte protein-tyrosine phosphatase [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from M68941.1 and BC010674.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This protein contains a C-terminal PTP
CC   domain and an N-terminal domain homologous to the band 4.1
CC   superfamily of cytoskeletal-associated proteins. This PTP has been
CC   shown to interact with glutamate receptor delta 2 and epsilon
CC   subunits, and is thought to play a role in signalling downstream of
CC   the glutamate receptors through tyrosine dephosphorylation.
CC   GPRFLN|REFERENCE   1  (residues 1 to 926)
CC   GPRFLN|  AUTHORS   Hironaka,K., Umemori,H., Tezuka,T., Mishina,M. and Yamamoto,T.
CC   GPRFLN|  TITLE     The protein-tyrosine phosphatase PTPMEG interacts with glutamate
CC   GPRFLN|            receptor delta 2 and epsilon subunits
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 275 (21), 16167-16173 (2000)
CC   GPRFLN|  MEDLINE   20283654
CC   GPRFLN|REFERENCE   2  (residues 1 to 926)
CC   GPRFLN|  AUTHORS   Gu,M., Meng,K. and Majerus,P.W.
CC   GPRFLN|  TITLE     The effect of overexpression of the protein tyrosine phosphatase
CC   GPRFLN|            PTPMEG on cell growth and on colony formation in soft agar in COS-7
CC   GPRFLN|            cells
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 93 (23), 12980-12985 (1996)
CC   GPRFLN|  MEDLINE   97075104
CC   GPRFLN|REFERENCE   3  (residues 1 to 926)
CC   GPRFLN|  AUTHORS   Gu,M. and Majerus,P.W.
CC   GPRFLN|  TITLE     The properties of the protein tyrosine phosphatase PTPMEG
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 271 (44), 27751-27759 (1996)
CC   GPRFLN|  MEDLINE   97066967
CC   GPRFLN|REFERENCE   4  (residues 1 to 926)
CC   GPRFLN|  AUTHORS   Gu,M.X., York,J.D., Warshawsky,I. and Majerus,P.W.
CC   GPRFLN|  TITLE     Identification, cloning, and expression of a cytosolic
CC   GPRFLN|            megakaryocyte protein-tyrosine-phosphatase with sequence homology
CC   GPRFLN|            to cytoskeletal protein 4.1
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 88 (13), 5867-5871 (1991)
CC   GPRFLN|  MEDLINE   91288564
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    277       VNTIFKEY:269
FT   PROTEIN       1    277       megakaryocyte phosphatase; PTPase-MEG1; protein tyrosine phosphatase MEG1; megakaryocyte protein-tyrosine phosphatase
FT                                VNTIFKEY:270
FT   REGION       19    277       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   277 AA;
     HSLRESMIQL AEGLITGTVL TQFDQLYRKK PGMTMSCAKL PQNISKNRYR DISPYDATRV        60
     ILKGNEDYIN ANYINMEIPS SSIINQYIAC QGPLPHTCTD FWQMTWEQGS SMVVMLTTQV       120
     ERGRVKCHQY WPEPTGSSSY GCYQVTCHSE EGNTAYIFRK MTLFNQEKNE SRPLTQIQYI       180
     AWPDHGVPDD SSDFLDFVCH VRNKRAGKEE PVVVHCSAGI GRTGVLITME TAMCLIECNQ       240
     PVYPLDIVRT MRDQRAMMIQ TPSQYRFVCE AILKVYE                                277
//
ID   hMEG2_D1\(NP_002824)\PTPN9 STANDARD;PRT;   291 AA.
AC   NP_002824;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, non-receptor type 9; protein-tyrosine phosphatase MEG2; PTPase-MEG2 [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from M83738.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP contains an N-terminal domain
CC   that shares a significant similarity with yeast SEC14, which is a
CC   protein that has phosphatidylinositol transfer activity and is
CC   required for protein secretion through the Golgi complex in yeast.
CC   This PTP was found to be activated by polyphosphoinositide, and is
CC   thought to be involved in signaling events regulating phagocytosis.
CC   GPRFLN|REFERENCE   1  (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Qi,Y., Zhao,R., Cao,H., Sui,X., Krantz,S.B. and Zhao,Z.J.
CC   GPRFLN|  TITLE     Purification and characterization of protein tyrosine phosphatase
CC   GPRFLN|            PTP-MEG2
CC   GPRFLN|  JOURNAL   J. Cell. Biochem. 86 (1), 79-89 (2002)
CC   GPRFLN|  MEDLINE   22106294
CC   GPRFLN|  REMARK    GeneRIF: Purification and characterization of protein tyrosine
CC   GPRFLN|            phosphatase PTP-MEG2
CC   GPRFLN|REFERENCE   2  (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Kruger,J.M., Fukushima,T., Cherepanov,V., Borregaard,N., Loeve,C.,
CC   GPRFLN|            Shek,C., Sharma,K., Tanswell,A.K., Chow,C.W. and Downey,G.P.
CC   GPRFLN|  TITLE     Protein-tyrosine phosphatase MEG2 is expressed by human
CC   GPRFLN|            neutrophils. Localization to the phagosome and activation by
CC   GPRFLN|            polyphosphoinositides
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (4), 2620-2628 (2002)
CC   GPRFLN|  MEDLINE   21659736
CC   GPRFLN|REFERENCE   3  (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Gu,M., Warshawsky,I. and Majerus,P.W.
CC   GPRFLN|  TITLE     Cloning and expression of a cytosolic megakaryocyte
CC   GPRFLN|            protein-tyrosine-phosphatase with sequence homology to
CC   GPRFLN|            retinaldehyde-binding protein and yeast SEC14p
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89 (7), 2980-2984 (1992)
CC   GPRFLN|  MEDLINE   92212952
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    291       VNTIFKEY:269
FT   PROTEIN       1    291       protein-tyrosine phosphatase MEG2; PTPase-MEG2
FT                                VNTIFKEY:270
FT   REGION       17    291       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   291 AA;
     MTIQELVDYV NARQKQGIYE EYEDIRRENP VGTFHCSMSP GNLEKNRYGD VPCLDQTRVK        60
     LTKRSGHTQT DYINASFMDG YKQKNAYIGT QGPLENTYRD FWLMVWEQKV LVIVMTTRFE       120
     EGGRRKCGQY WPLEKDSRIR FGFLTVTNLG VENMNHYKKT TLEIHNTEER QKRQVTHFQF       180
     LSWPDYGVPS SAASLIDFLR VVRNQQSLAV SNMGARSKGQ CPEPPIVVHC SAGIGRTGTF       240
     CSLDICLAQL EELGTLNVFQ TVSRMRTQRA FSIQTPEQYY FCYKAILEFA E                291
//
ID   hPCPTP1_D1\(NP_002840)\PTPRR STANDARD;PRT;   275 AA.
AC   NP_002840;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, R isoform 1 precursor; protein tyrosine phosphatase, receptor type, Q; protein-tyrosine phosphatase NC-PTPCOM1; protein tyrosine phosphatase Cr1PTPase precursor; Ch-1 PTPase [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from D64053.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP possesses an extracellular
CC   region, a single transmembrane region, and a single intracellular
CC   catalytic domains, and thus represents a receptor-type PTP. The
CC   similar gene predominately expressed in mouse brain was found to
CC   associate with, and thus regulate the activity and cellular
CC   localization of MAP kinases. The rat counterpart of this gene was
CC   reported to be regulated by the nerve growth factor, which
CC   suggested the function of this gene in neuronal growth and
CC   differentiation.
CC   
CC   Transcript Variant: This variant (1) contains a different 5' end
CC   region when compared to variant 2. It thus encodes a protein that
CC   has a longer N-terminus, as compared to isoform 2.
CC   GPRFLN|REFERENCE   1  (residues 1 to 657)
CC   GPRFLN|  AUTHORS   Blanco-Aparicio,C., Torres,J. and Pulido,R.
CC   GPRFLN|  TITLE     A novel regulatory mechanism of MAP kinases activation and nuclear
CC   GPRFLN|            translocation mediated by PKA and the PTP-SL tyrosine phosphatase
CC   GPRFLN|  JOURNAL   J. Cell Biol. 147 (6), 1129-1136 (1999)
CC   GPRFLN|  MEDLINE   20069779
CC   GPRFLN|REFERENCE   2  (residues 1 to 657)
CC   GPRFLN|  AUTHORS   Shiozuka,K., Watanabe,Y., Ikeda,T., Hashimoto,S. and Kawashima,H.
CC   GPRFLN|  TITLE     Cloning and expression of PCPTP1 encoding protein tyrosine
CC   GPRFLN|            phosphatase
CC   GPRFLN|  JOURNAL   Gene 162 (2), 279-284 (1995)
CC   GPRFLN|  MEDLINE   96032358
CC   GPRFLN|  REMARK    founctional study of the rat homolog
CC   GPRFLN|REFERENCE   3  (residues 1 to 657)
CC   GPRFLN|  AUTHORS   Ogata,M., Sawada,M., Fujino,Y. and Hamaoka,T.
CC   GPRFLN|  TITLE     cDNA cloning and characterization of a novel receptor-type protein
CC   GPRFLN|            tyrosine phosphatase expressed predominantly in the brain
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 270 (5), 2337-2343 (1995)
CC   GPRFLN|  MEDLINE   95138207
CC   GPRFLN|  REMARK    functional study of the mouse homolog
CC   GPRFLN|REFERENCE   4  (residues 1 to 657)
CC   GPRFLN|  AUTHORS   Sharma,E. and Lombroso,P.J.
CC   GPRFLN|  TITLE     A neuronal protein tyrosine phosphatase induced by nerve growth
CC   GPRFLN|            factor
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 270 (1), 49-53 (1995)
CC   GPRFLN|  MEDLINE   95113874
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    275       VNTIFKEY:269
FT   PROTEIN       1    275       protein tyrosine phosphatase, receptor type, Q; protein-tyrosine phosphatase NC-PTPCOM1; protein tyrosine phosphatase Cr1PTPase precursor; Ch-1 PTPase
FT                                VNTIFKEY:270
FT   CHAIN         1    275       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       18    273       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   275 AA;
     SRILTRSQLR DVVASSHLLQ SEFMEIPMNF VDPKEIDIPR HGTKNRYKTI LPNPLSRVCL        60
     RPKNVTDSLS TYINANYIRG YSGKEKAFIA TQGPMINTVD DFWQMVWQED SPVIVMITKL       120
     KEKNEKCVLY WPEKRGIYGK VEVLVISVNE CDNYTIRNLV LKQGSHTQHV KHYWYTSWPD       180
     HKTPDSAQPL LQLMLDVEED RLASQGRGPV VVHCSAGIGR TGCFIATSIG CQQLKEEGVV       240
     DALSIVCQLR MDRGGMVQTS EQYEFVHHAL CLYES                                  275
//
ID   hPEST_D1\(NP_002826)\PTPN12 STANDARD;PRT;   288 AA.
AC   NP_002826;
DT   3-JUL-2003
DE   protein tyrosine phosphatase, non-receptor type 12; protein-tyrosine phosphatase G1 [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from M93425.1.
CC   On Jan 25, 2002 this sequence version replaced gi:4506287.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP contains a C-terminal PEST
CC   motif, which serves as a protein-protein interaction domain, and
CC   may be related to protein intracellular half-life. This PTP was
CC   found to bind and dephosphorylate the product of oncogene c-ABL,
CC   thus may play a role in oncogenesis. This PTP was shown to interact
CC   with, and dephosphorylate, various of cytoskeleton and cell
CC   adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and
CC   paxillin, which suggested its regulatory roles in controlling cell
CC   shape and mobility.
CC   GPRFLN|REFERENCE   1  (residues 1 to 780)
CC   GPRFLN|  AUTHORS   Lyons,P.D., Dunty,J.M., Schaefer,E.M. and Schaller,M.D.
CC   GPRFLN|  TITLE     Inhibition of the catalytic activity of cell adhesion kinase beta
CC   GPRFLN|            by protein-tyrosine phosphatase-PEST-mediated dephosphorylation
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 276 (26), 24422-24431 (2001)
CC   GPRFLN|  MEDLINE   21316574
CC   GPRFLN|REFERENCE   2  (residues 1 to 780)
CC   GPRFLN|  AUTHORS   Cong,F., Spencer,S., Cote,J.F., Wu,Y., Tremblay,M.L., Lasky,L.A.
CC   GPRFLN|            and Goff,S.P.
CC   GPRFLN|  TITLE     Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine
CC   GPRFLN|            phosphatase to the c-Abl kinase to mediate Abl dephosphorylation
CC   GPRFLN|  JOURNAL   Mol. Cell 6 (6), 1413-1423 (2000)
CC   GPRFLN|  MEDLINE   21111050
CC   GPRFLN|REFERENCE   3  (residues 1 to 780)
CC   GPRFLN|  AUTHORS   Shen,Y., Lyons,P., Cooley,M., Davidson,D., Veillette,A., Salgia,R.,
CC   GPRFLN|            Griffin,J.D. and Schaller,M.D.
CC   GPRFLN|  TITLE     The noncatalytic domain of protein-tyrosine phosphatase-PEST
CC   GPRFLN|            targets paxillin for dephosphorylation in vivo
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 275 (2), 1405-1413 (2000)
CC   GPRFLN|  MEDLINE   20092920
CC   GPRFLN|REFERENCE   4  (residues 1 to 780)
CC   GPRFLN|  AUTHORS   Nishiya,N., Iwabuchi,Y., Shibanuma,M., Cote,J.F., Tremblay,M.L. and
CC   GPRFLN|            Nose,K.
CC   GPRFLN|  TITLE     Hic-5, a paxillin homologue, binds to the protein-tyrosine
CC   GPRFLN|            phosphatase PEST (PTP-PEST) through its LIM 3 domain
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 274 (14), 9847-9853 (1999)
CC   GPRFLN|  MEDLINE   99194842
CC   GPRFLN|REFERENCE   5  (residues 1 to 780)
CC   GPRFLN|  AUTHORS   Garton,A.J. and Tonks,N.K.
CC   GPRFLN|  TITLE     Regulation of fibroblast motility by the protein tyrosine
CC   GPRFLN|            phosphatase PTP-PEST
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 274 (6), 3811-3818 (1999)
CC   GPRFLN|  MEDLINE   99121127
CC   GPRFLN|REFERENCE   6  (residues 1 to 780)
CC   GPRFLN|  AUTHORS   Takekawa,M., Itoh,F., Hinoda,Y., Adachi,M., Ariyama,T., Inazawa,J.,
CC   GPRFLN|            Imai,K. and Yachi,A.
CC   GPRFLN|  TITLE     Chromosomal localization of the protein tyrosine phosphatase G1
CC   GPRFLN|            gene and characterization of the aberrant transcripts in human
CC   GPRFLN|            colon cancer cells
CC   GPRFLN|  JOURNAL   FEBS Lett. 339 (3), 222-228 (1994)
CC   GPRFLN|  MEDLINE   94156037
CC   GPRFLN|REFERENCE   7  (residues 1 to 780)
CC   GPRFLN|  AUTHORS   Yang,Q., Co,D., Sommercorn,J. and Tonks,N.K.
CC   GPRFLN|  TITLE     Cloning and expression of PTP-PEST. A novel, human,
CC   GPRFLN|            nontransmembrane protein tyrosine phosphatase
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 268 (9), 6622-6628 (1993)
CC   GPRFLN|  MEDLINE   93203262
CC   GPRFLN|REFERENCE   8  (residues 1 to 780)
CC   GPRFLN|  AUTHORS   Takekawa,M., Itoh,F., Hinoda,Y., Arimura,Y., Toyota,M., Sekiya,M.,
CC   GPRFLN|            Adachi,M., Imai,K. and Yachi,A.
CC   GPRFLN|  TITLE     Cloning and characterization of a human cDNA encoding a novel
CC   GPRFLN|            putative cytoplasmic protein-tyrosine-phosphatase
CC   GPRFLN|  JOURNAL   Biochem. Biophys. Res. Commun. 189 (2), 1223-1230 (1992)
CC   GPRFLN|  MEDLINE   93112015
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|JNA|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    288       VNTIFKEY:269
FT   PROTEIN       1    288       protein-tyrosine phosphatase G1
FT                                VNTIFKEY:270
FT   REGION       21    288       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   288 AA;
     RKFIQRVQAM KSPDHNGEDN FARDFMRLRR LSTKYRTEKI YPTATGEKEE NVKKNRYKDI        60
     LPFDHSRVKL TLKTPSQDSD YINANFIKGV YGPKAYVATQ GPLANTVIDF WRMIWEYNVV       120
     IIVMACREFE MGRKKCERYW PLYGEDPITF APFKISCEDE QARTDYFIRT LLLEFQNESR       180
     RLYQFHYVNW PDHDVPSSFD SILDMISLMR KYQEHEDVPI CIHCSAGCGR TGAICAIDYT       240
     WNLLKAGKIP EEFNVFNLIQ EMRTQRHSAV QTKEQYELVH RAIAQLFE                    288
//
ID   hPTP1B_D1\(NP_002818)\PTPN1 STANDARD;PRT;   279 AA.
AC   NP_002818;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, non-receptor type 1; non-receptor tyrosine phophatase 1; protein tyrosine phophatase 1B; protein tyrosine phophatase, placental [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from M33689.1 and AU117677.1.
CC   
CC   Summary: The protein encoded by this gene is the founding member of
CC   the protein tyrosine phosphatase (PTP) family, which was isolated
CC   and identified based on its enzymatic activity and amino acid
CC   sequence. PTPs catalyze the hydrolysis of the phosphate monoesters
CC   specifically on tyrosine residues. Members of the PTP family share
CC   a highly conserved catalytic motif, which is essential for the
CC   catalytic activity. PTPs are known to be signaling molecules that
CC   regulate a variety of cellular processes including cell growth,
CC   differentiation, mitotic cycle, and oncogenic transformation. This
CC   PTP has been shown to act as a negative regulator of insulin
CC   signaling by dephosphorylating the phosphotryosine residues of
CC   insulin receptor kinase. This PTP was also reported to
CC   dephosphorylate epidermal growth factor receptor kinase, as well as
CC   JAK2 and TYK2 kinases, which implicated the role of this PTP in
CC   cell growth control, and cell response to interferon stimulation.
CC   GPRFLN|REFERENCE   1  (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Li,S. and Whorton,A.R.
CC   GPRFLN|  TITLE     Regulation of protein tyrosine phosphatase 1B in intact cells by
CC   GPRFLN|            S-nitrosothiols
CC   GPRFLN|  JOURNAL   Arch. Biochem. Biophys. 410 (2), 269-279 (2003)
CC   GPRFLN|  MEDLINE   22461115
CC   GPRFLN|  REMARK    GeneRIF: PTP1B inhibition by S-nitrosylation is caused by formation
CC   GPRFLN|            of a mixed disulfide
CC   GPRFLN|REFERENCE   2  (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Fukada,T. and Tonks,N.K.
CC   GPRFLN|  TITLE     Identification of YB-1 as a regulator of PTP1B expression:
CC   GPRFLN|            implications for regulation of insulin and cytokine signaling
CC   GPRFLN|  JOURNAL   EMBO J. 22 (3), 479-493 (2003)
CC   GPRFLN|  MEDLINE   22441887
CC   GPRFLN|  REMARK    GeneRIF: Data show that Y box-binding protein-1 (YB-1) is a
CC   GPRFLN|            regulator of protein tyrosine phosphatase 1B (PTP1B) expression,
CC   GPRFLN|            and highlight PTP1B as a critical regulator of insulin- and
CC   GPRFLN|            cytokine-mediated signal transduction.
CC   GPRFLN|REFERENCE   3  (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Yigzaw,Y., Poppleton,H.M., Sreejayan,N., Hassid,A. and Patel,T.B.
CC   GPRFLN|  TITLE     Protein-tyrosine phosphatase-1B (PTP1B) mediates the anti-migratory
CC   GPRFLN|            actions of Sprouty
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 278 (1), 284-288 (2003)
CC   GPRFLN|  MEDLINE   22393490
CC   GPRFLN|  REMARK    GeneRIF: Data show that an increase in soluble protein-tyrosine
CC   GPRFLN|            phosphatase 1B activity contributes to the anti-migratory, but not
CC   GPRFLN|            anti-mitogenic, actions of human Sprouty 2.
CC   GPRFLN|REFERENCE   4  (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Di Paola,R., Frittitta,L., Miscio,G., Bozzali,M., Baratta,R.,
CC   GPRFLN|            Centra,M., Spampinato,D., Santagati,M.G., Ercolino,T.,
CC   GPRFLN|            Cisternino,C., Soccio,T., Mastroianno,S., Tassi,V., Almgren,P.,
CC   GPRFLN|            Pizzuti,A., Vigneri,R. and Trischitta,V.
CC   GPRFLN|  TITLE     A variation in 3' UTR of hPTP1B increases specific gene expression
CC   GPRFLN|            and associates with insulin resistance
CC   GPRFLN|  JOURNAL   Am. J. Hum. Genet. 70 (3), 806-812 (2002)
CC   GPRFLN|  MEDLINE   21832513
CC   GPRFLN|  REMARK    GeneRIF: variation in 3' UTR of hPTP1B increases specific gene
CC   GPRFLN|            expression and associates with insulin resistance
CC   GPRFLN|REFERENCE   5  (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Myers,M.P., Andersen,J.N., Cheng,A., Tremblay,M.L., Horvath,C.M.,
CC   GPRFLN|            Parisien,J.P., Salmeen,A., Barford,D. and Tonks,N.K.
CC   GPRFLN|  TITLE     TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 276 (51), 47771-47774 (2001)
CC   GPRFLN|  MEDLINE   21611285
CC   GPRFLN|REFERENCE   6  (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Wang,J., Cheung,A.T., Kolls,J.K., Starks,W.W.,
CC   GPRFLN|            Martinez-Hernandez,A., Dietzen,D. and Bryer-Ash,M.
CC   GPRFLN|  TITLE     Effects of adenovirus-mediated liver-selective overexpression of
CC   GPRFLN|            protein tyrosine phosphatase-1b on insulin sensitivity in vivo
CC   GPRFLN|  JOURNAL   Diabetes Obes Metab 3 (5), 367-380 (2001)
CC   GPRFLN|  MEDLINE   21560532
CC   GPRFLN|  REMARK    GeneRIF: Moderate overabundance of PTP-1B in liver tissue does not
CC   GPRFLN|            alter insulin action on glucose metabolism, and the site of action
CC   GPRFLN|            of PTP-1B is presumably at insulin-responsive target tissue or
CC   GPRFLN|            tissues other than the liver.
CC   GPRFLN|REFERENCE   7  (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Dadke,S., Kusari,A. and Kusari,J.
CC   GPRFLN|  TITLE     Phosphorylation and activation of protein tyrosine phosphatase
CC   GPRFLN|            (PTP) 1B by insulin receptor
CC   GPRFLN|  JOURNAL   Mol. Cell. Biochem. 221 (1-2), 147-154 (2001)
CC   GPRFLN|  MEDLINE   21396990
CC   GPRFLN|REFERENCE   8  (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Egawa,K., Maegawa,H., Shimizu,S., Morino,K., Nishio,Y.,
CC   GPRFLN|            Bryer-Ash,M., Cheung,A.T., Kolls,J.K., Kikkawa,R. and Kashiwagi,A.
CC   GPRFLN|  TITLE     Protein-tyrosine phosphatase-1B negatively regulates insulin
CC   GPRFLN|            signaling in l6 myocytes and Fao hepatoma cells
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 276 (13), 10207-10211 (2001)
CC   GPRFLN|  MEDLINE   21167830
CC   GPRFLN|REFERENCE   9  (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Salmeen,A., Andersen,J.N., Myers,M.P., Tonks,N.K. and Barford,D.
CC   GPRFLN|  TITLE     Molecular basis for the dephosphorylation of the activation segment
CC   GPRFLN|            of the insulin receptor by protein tyrosine phosphatase 1B
CC   GPRFLN|  JOURNAL   Mol. Cell 6 (6), 1401-1412 (2000)
CC   GPRFLN|  MEDLINE   21111049
CC   GPRFLN|REFERENCE   10 (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Peters,G.H., Iversen,L.F., Branner,S., Andersen,H.S.,
CC   GPRFLN|            Mortensen,S.B., Olsen,O.H., Moller,K.B. and Moller,N.P.
CC   GPRFLN|  TITLE     Residue 259 is a key determinant of substrate specificity of
CC   GPRFLN|            protein-tyrosine phosphatases 1B and alpha
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 275 (24), 18201-18209 (2000)
CC   GPRFLN|  MEDLINE   20309769
CC   GPRFLN|REFERENCE   11 (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Ahmad,F., Li,P.M., Meyerovitch,J. and Goldstein,B.J.
CC   GPRFLN|  TITLE     Osmotic loading of neutralizing antibodies demonstrates a role for
CC   GPRFLN|            protein-tyrosine phosphatase 1B in negative regulation of the
CC   GPRFLN|            insulin action pathway
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 270 (35), 20503-20508 (1995)
CC   GPRFLN|  MEDLINE   95386495
CC   GPRFLN|REFERENCE   12 (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Milarski,K.L., Zhu,G., Pearl,C.G., McNamara,D.J., Dobrusin,E.M.,
CC   GPRFLN|            MacLean,D., Thieme-Sefler,A., Zhang,Z.Y., Sawyer,T., Decker,S.J. et
CC   GPRFLN|            al.
CC   GPRFLN|  TITLE     Sequence specificity in recognition of the epidermal growth factor
CC   GPRFLN|            receptor by protein tyrosine phosphatase 1B
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 268 (31), 23634-23639 (1993)
CC   GPRFLN|  MEDLINE   94043167
CC   GPRFLN|REFERENCE   13 (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Brown-Shimer,S., Johnson,K.A., Lawrence,J.B., Johnson,C.,
CC   GPRFLN|            Bruskin,A., Green,N.R. and Hill,D.E.
CC   GPRFLN|  TITLE     Molecular cloning and chromosome mapping of the human gene encoding
CC   GPRFLN|            protein phosphotyrosyl phosphatase 1B
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (13), 5148-5152 (1990)
CC   GPRFLN|  MEDLINE   90311360
CC   GPRFLN|REFERENCE   14 (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Chernoff,J., Schievella,A.R., Jost,C.A., Erikson,R.L. and Neel,B.G.
CC   GPRFLN|  TITLE     Cloning of a cDNA for a major human protein-tyrosine-phosphatase
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (7), 2735-2739 (1990)
CC   GPRFLN|  MEDLINE   90207272
CC   GPRFLN|REFERENCE   15 (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Charbonneau,H., Tonks,N.K., Kumar,S., Diltz,C.D., Harrylock,M.,
CC   GPRFLN|            Cool,D.E., Krebs,E.G., Fischer,E.H. and Walsh,K.A.
CC   GPRFLN|  TITLE     Human placenta protein-tyrosine-phosphatase: amino acid sequence
CC   GPRFLN|            and relationship to a family of receptor-like proteins
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 86 (14), 5252-5256 (1989)
CC   GPRFLN|  MEDLINE   89315775
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    279       VNTIFKEY:269
FT   PROTEIN       1    279       non-receptor tyrosine phophatase 1; protein tyrosine phophatase 1B; protein tyrosine phophatase, placental
FT                                VNTIFKEY:270
FT   REGION        3    279       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   279 AA;
     MEMEKEFEQI DKSGSWAAIY QDIRHEASDF PCRVAKLPKN KNRNRYRDVS PFDHSRIKLH        60
     QEDNDYINAS LIKMEEAQRS YILTQGPLPN TCGHFWEMVW EQKSRGVVML NRVMEKGSLK       120
     CAQYWPQKEE KEMIFEDTNL KLTLISEDIK SYYTVRQLEL ENLTTQETRE ILHFHYTTWP       180
     DFGVPESPAS FLNFLFKVRE SGSLSPEHGP VVVHCSAGIG RSGTFCLADT CLLLMDKRKD       240
     PSSVDIKKVL LEMRKFRMGL IQTADQLRFS YLAVIEGAK                              279
//
ID   hPTPalpha_D1\(NP_002827)\PTPRA STANDARD;PRT;   280 AA.
AC   NP_002827;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, A isoform 1 precursor; protein tyrosine phosphatase, receptor type, alpha polypeptide; PTPase-alpha; Leukocyte common antigen-related peptide (protein tyrosine phosphate); tyrosine phosphatase alpha; PTPLCA-related phosphatase [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from M34668.1 and AI284972.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP contains an extracellular
CC   domain, a single transmembrane segment and two tandem
CC   intracytoplasmic catalytic domains, and thus represents a
CC   receptor-type PTP. This PTP has been shown to dephosphorylate and
CC   activate Src family tyrosine kinases, and is implicated in the
CC   regulation of integrin signaling, cell adhesion and proliferation.
CC   Three alternatively spliced variants of this gene, which encode two
CC   distinct isoforms, have been reported.
CC   
CC   Transcript Variant: This variant (1) contains a unique 5' UTR
CC   region when compared to other variants. The genomic exons forming
CC   the 5' end region of this transcript are also used to form an
CC   internal coding region in the transcripts of VPS16, a distinct gene
CC   located at the locus immediately upstream of this gene on
CC   chromosome 20. This variant encodes the longest isoform (1).
CC   GPRFLN|REFERENCE   1  (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J.
CC   GPRFLN|  TITLE     Intra- and intermolecular interactions between intracellular
CC   GPRFLN|            domains of receptor protein-tyrosine phosphatases
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (49), 47263-47269 (2002)
CC   GPRFLN|  MEDLINE   22344739
CC   GPRFLN|  REMARK    GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are
CC   GPRFLN|            a common but specific mechanism that is likely to be regulated-
CC   GPRFLN|            domain2s and the wedge structures are crucial determinants of
CC   GPRFLN|            binding specificity, thus regulating cross-talk between RPTPs
CC   GPRFLN|REFERENCE   2  (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Mustelin,T. and Hunter,T.
CC   GPRFLN|  TITLE     Meeting at mitosis: cell cycle-specific regulation of c-Src by
CC   GPRFLN|            RPTPalpha
CC   GPRFLN|  JOURNAL   Sci STKE 2002 (115), PE3 (2002)
CC   GPRFLN|  MEDLINE   21655780
CC   GPRFLN|  REMARK    GeneRIF: In entering mitosis the cell cycle-specific regulation of
CC   GPRFLN|            c-Src by RPTPalpha can occur by dephosphorylation of phospho-Tyr527
CC   GPRFLN|            that activates c-Src in a reaction catalyzed by the transmembrane
CC   GPRFLN|            receptor-like protein tyrosine phosphatase RPTPalpha.
CC   GPRFLN|REFERENCE   3  (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Ardini,E., Agresti,R., Tagliabue,E., Greco,M., Aiello,P.,
CC   GPRFLN|            Yang,L.T., Menard,S. and Sap,J.
CC   GPRFLN|  TITLE     Expression of protein tyrosine phosphatase alpha (RPTPalpha) in
CC   GPRFLN|            human breast cancer correlates with low tumor grade, and inhibits
CC   GPRFLN|            tumor cell growth in vitro and in vivo
CC   GPRFLN|  JOURNAL   Oncogene 19 (43), 4979-4987 (2000)
CC   GPRFLN|  MEDLINE   20499263
CC   GPRFLN|REFERENCE   4  (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Peters,G.H., Iversen,L.F., Branner,S., Andersen,H.S.,
CC   GPRFLN|            Mortensen,S.B., Olsen,O.H., Moller,K.B. and Moller,N.P.
CC   GPRFLN|  TITLE     Residue 259 is a key determinant of substrate specificity of
CC   GPRFLN|            protein-tyrosine phosphatases 1B and alpha
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 275 (24), 18201-18209 (2000)
CC   GPRFLN|  MEDLINE   20309769
CC   GPRFLN|REFERENCE   5  (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Harder,K.W., Moller,N.P., Peacock,J.W. and Jirik,F.R.
CC   GPRFLN|  TITLE     Protein-tyrosine phosphatase alpha regulates Src family kinases and
CC   GPRFLN|            alters cell-substratum adhesion
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 273 (48), 31890-31900 (1998)
CC   GPRFLN|  MEDLINE   99041953
CC   GPRFLN|REFERENCE   6  (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Zheng,X.M., Wang,Y. and Pallen,C.J.
CC   GPRFLN|  TITLE     Cell transformation and activation of pp60c-src by overexpression
CC   GPRFLN|            of a protein tyrosine phosphatase
CC   GPRFLN|  JOURNAL   Nature 359 (6393), 336-339 (1992)
CC   GPRFLN|  MEDLINE   93024881
CC   GPRFLN|REFERENCE   7  (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Rao,V.V., Loffler,C., Sap,J., Schlessinger,J. and Hansmann,I.
CC   GPRFLN|  TITLE     The gene for receptor-linked protein-tyrosine-phosphatase (PTPA) is
CC   GPRFLN|            assigned to human chromosome 20p12-pter by in situ hybridization
CC   GPRFLN|            (ISH and FISH)
CC   GPRFLN|  JOURNAL   Genomics 13 (3), 906-907 (1992)
CC   GPRFLN|  MEDLINE   92347910
CC   GPRFLN|REFERENCE   8  (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Ohagi,S., Nishi,M. and Steiner,D.F.
CC   GPRFLN|  TITLE     Sequence of a cDNA encoding human LRP (leukocyte common
CC   GPRFLN|            antigen-related peptide)
CC   GPRFLN|  JOURNAL   Nucleic Acids Res. 18 (23), 7159 (1990)
CC   GPRFLN|  MEDLINE   91088320
CC   GPRFLN|REFERENCE   9  (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Jirik,F.R., Janzen,N.M., Melhado,I.G. and Harder,K.W.
CC   GPRFLN|  TITLE     Cloning and chromosomal assignment of a widely expressed human
CC   GPRFLN|            receptor-like protein-tyrosine phosphatase
CC   GPRFLN|  JOURNAL   FEBS Lett. 273 (1-2), 239-242 (1990)
CC   GPRFLN|  MEDLINE   91032191
CC   GPRFLN|REFERENCE   10 (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Krueger,N.X., Streuli,M. and Saito,H.
CC   GPRFLN|  TITLE     Structural diversity and evolution of human receptor-like protein
CC   GPRFLN|            tyrosine phosphatases
CC   GPRFLN|  JOURNAL   EMBO J. 9 (10), 3241-3252 (1990)
CC   GPRFLN|  MEDLINE   91006018
CC   GPRFLN|REFERENCE   11 (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Kaplan,R., Morse,B., Huebner,K., Croce,C., Howk,R., Ravera,M.,
CC   GPRFLN|            Ricca,G., Jaye,M. and Schlessinger,J.
CC   GPRFLN|  TITLE     Cloning of three human tyrosine phosphatases reveals a multigene
CC   GPRFLN|            family of receptor-linked protein-tyrosine-phosphatases expressed
CC   GPRFLN|            in brain
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (18), 7000-7004 (1990)
CC   GPRFLN|  MEDLINE   90384936
CC   GPRFLN|REFERENCE   12 (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Sap,J., D'Eustachio,P., Givol,D. and Schlessinger,J.
CC   GPRFLN|  TITLE     Cloning and expression of a widely expressed receptor tyrosine
CC   GPRFLN|            phosphatase
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (16), 6112-6116 (1990)
CC   GPRFLN|  MEDLINE   90349565
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    280       VNTIFKEY:269
FT   PROTEIN       1    280       protein tyrosine phosphatase, receptor type, alpha polypeptide; PTPase-alpha; Leukocyte common antigen-related peptide (protein tyrosine phosphate); tyrosine phosphatase alpha; PTPLCA-related phosphatase
FT                                VNTIFKEY:270
FT   CHAIN         1    280       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       17    280       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   280 AA;
     DKLEEEINRR MADDNKLFRE EFNALPACPI QATCEAASKE ENKEKNRYVN ILPYDHSRVH        60
     LTPVEGVPDS DYINASFING YQEKNKFIAA QGPKEETVND FWRMIWEQNT ATIVMVTNLK       120
     ERKECKCAQY WPDQGCWTYG NIRVSVEDVT VLVDYTVRKF CIQQVGDMTN RKPQRLITQF       180
     HFTSWPDFGV PFTPIGMLKF LKKVKACNPQ YAGAIVVHCS AGVGRTGTFV VIDAMLDMMH       240
     TERKVDVYGF VSRIRAQRCQ MVQTDMQYVF IYQALLEHYL                             280
//
ID   hPTPBAS_D1\(NP_006255)\PTPN13 STANDARD;PRT;   275 AA.
AC   NP_006255;
DT   30-JUN-2003
DE   protein tyrosine phosphatase, non-receptor type 13 isoform 2; protein tyrosine phosphatase, nonreceptor type 13; protein tyrosine phosphatase 1E; Fas-associated phosphatase-1; protein-tyrosine phosphatase 1, Fas-associated; protein-tyrosine phophatase PTPL1; APO-1/CD95 (Fas)-associated phosphatase [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from D21210.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP is a large protein that
CC   possesses a PTP domain at C-terminus, and multiple noncatalytic
CC   domains, which include a domain with similarity to band 4.1
CC   superfamily of cytoskeletal-associated proteins, a region
CC   consisting of five PDZ domains, and a leucine zipper motif. This
CC   PTP was found to interact with, and dephosphorylate Fas receptor,
CC   as well as IkappaBalpha through the PDZ domains, which suggested
CC   its role in Fas mediated programmed cell death. This PTP was also
CC   shown to interact with GTPase-activating protein, and thus may
CC   function as a regulator of Rho signaling pathway. Four
CC   alternatively spliced transcript variants, which encode distinct
CC   proteins, have been reported.
CC   
CC   Transcript Variant: This variant (2) lacks an internal fragment
CC   within the coding region when compared to variant 4. The
CC   translation remains in frame, and the encoded protein lacks
CC   internal 19 aa, as compared to isoform 4.
CC   GPRFLN|REFERENCE   1  (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Yoshida,S., Harada,H., Nagai,H., Fukino,K., Teramoto,A. and Emi,M.
CC   GPRFLN|  TITLE     Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1)
CC   GPRFLN|            and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and
CC   GPRFLN|            seven polymorphisms of the FAP-1 gene
CC   GPRFLN|  JOURNAL   J. Hum. Genet. 47 (11), 614-619 (2002)
CC   GPRFLN|  MEDLINE   22323362
CC   GPRFLN|  REMARK    GeneRIF: Shares a promoter region with the tightly linked gene
CC   GPRFLN|            encoding stress-activated protein kinase JNK3.
CC   GPRFLN|REFERENCE   2  (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Bompard,G., Puech,C., Prebois,C., Vignon,F. and Freiss,G.
CC   GPRFLN|  TITLE     Protein-tyrosine phosphatase PTPL1/FAP-1 triggers apoptosis in
CC   GPRFLN|            human breast cancer cells
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (49), 47861-47869 (2002)
CC   GPRFLN|  MEDLINE   22344658
CC   GPRFLN|  REMARK    GeneRIF: PTPL1/FAP-1 has a key role in the apoptotic process in
CC   GPRFLN|            human breast cancer cells independent of Fas but associated with an
CC   GPRFLN|            early inhibition of the insulin receptor
CC   GPRFLN|            substrate-1/phosphatidylinositol 3-kinase pathway
CC   GPRFLN|REFERENCE   3  (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Kozlov,G., Banville,D., Gehring,K. and Ekiel,I.
CC   GPRFLN|  TITLE     Solution structure of the PDZ2 domain from cytosolic human
CC   GPRFLN|            phosphatase hPTP1E complexed with a peptide reveals contribution of
CC   GPRFLN|            the beta2-beta3 loop to PDZ domain-ligand interactions
CC   GPRFLN|  JOURNAL   J. Mol. Biol. 320 (4), 813-820 (2002)
CC   GPRFLN|  MEDLINE   22090786
CC   GPRFLN|  REMARK    GeneRIF: PDZ2 domain from cytosolic human phosphatase hPTP1E
CC   GPRFLN|            complexed with peptide, RA-GEF-2, reveals contribution of the
CC   GPRFLN|            beta2-beta3 loop to PDZ domain-ligand interactions
CC   GPRFLN|REFERENCE   4  (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Walma,T., Spronk,C.A., Tessari,M., Aelen,J., Schepens,J.,
CC   GPRFLN|            Hendriks,W. and Vuister,G.W.
CC   GPRFLN|  TITLE     Structure, dynamics and binding characteristics of the second PDZ
CC   GPRFLN|            domain of PTP-BL
CC   GPRFLN|  JOURNAL   J. Mol. Biol. 316 (5), 1101-1110 (2002)
CC   GPRFLN|  MEDLINE   21881810
CC   GPRFLN|  REMARK    GeneRIF: Structure, dynamics and binding characteristics of the
CC   GPRFLN|            second PDZ domain of PTP-BL
CC   GPRFLN|REFERENCE   5  (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Marin,L., Minguela,A., Moya-Quiles,M.R., Torio,A., Muro,M.,
CC   GPRFLN|            Garcia-Alonso,A.M., Sanchez-Bueno,F., Bru,M., Parrilla,P. and
CC   GPRFLN|            Alvarez-Lopez,M.R.
CC   GPRFLN|  TITLE     Expression of CD95 and apoptosis induction in peripheral blood
CC   GPRFLN|            cells from liver graft recipients
CC   GPRFLN|  JOURNAL   Transplant. Proc. 34 (1), 280-282 (2002)
CC   GPRFLN|  MEDLINE   21957524
CC   GPRFLN|  REMARK    GeneRIF: expression and apoptosis induction in peripheral blood
CC   GPRFLN|            cells from liver graft
CC   GPRFLN|REFERENCE   6  (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Nakai,Y., Irie,S. and Sato,T.A.
CC   GPRFLN|  TITLE     Identification of IkappaBalpha as a substrate of Fas-associated
CC   GPRFLN|            phosphatase-1
CC   GPRFLN|  JOURNAL   Eur. J. Biochem. 267 (24), 7170-7175 (2000)
CC   GPRFLN|  MEDLINE   20558254
CC   GPRFLN|REFERENCE   7  (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Irie,S., Hachiya,T., Rabizadeh,S., Maruyama,W., Mukai,J., Li,Y.,
CC   GPRFLN|            Reed,J.C., Bredesen,D.E. and Sato,T.A.
CC   GPRFLN|  TITLE     Functional interaction of Fas-associated phosphatase-1 (FAP-1) with
CC   GPRFLN|            p75(NTR) and their effect on NF-kappaB activation
CC   GPRFLN|  JOURNAL   FEBS Lett. 460 (2), 191-198 (1999)
CC   GPRFLN|  MEDLINE   20012928
CC   GPRFLN|REFERENCE   8  (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Maekawa,K., Imagawa,N., Naito,A., Harada,S., Yoshie,O. and
CC   GPRFLN|            Takagi,S.
CC   GPRFLN|  TITLE     Association of protein-tyrosine phosphatase PTP-BAS with the
CC   GPRFLN|            transcription-factor-inhibitory protein IkappaBalpha through
CC   GPRFLN|            interaction between the PDZ1 domain and ankyrin repeats
CC   GPRFLN|  JOURNAL   Biochem. J. 337 (Pt 2), 179-184 (1999)
CC   GPRFLN|  MEDLINE   99102074
CC   GPRFLN|REFERENCE   9  (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Saras,J., Franzen,P., Aspenstrom,P., Hellman,U., Gonez,L.J. and
CC   GPRFLN|            Heldin,C.H.
CC   GPRFLN|  TITLE     A novel GTPase-activating protein for Rho interacts with a PDZ
CC   GPRFLN|            domain of the protein-tyrosine phosphatase PTPL1
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 272 (39), 24333-24338 (1997)
CC   GPRFLN|  MEDLINE   97450957
CC   GPRFLN|REFERENCE   10 (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Saras,J., Engstrom,U., Gonez,L.J. and Heldin,C.H.
CC   GPRFLN|  TITLE     Characterization of the interactions between PDZ domains of the
CC   GPRFLN|            protein-tyrosine phosphatase PTPL1 and the carboxyl-terminal tail
CC   GPRFLN|            of Fas
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 272 (34), 20979-20981 (1997)
CC   GPRFLN|  MEDLINE   97407871
CC   GPRFLN|REFERENCE   11 (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Yanagisawa,J., Takahashi,M., Kanki,H., Yano-Yanagisawa,H.,
CC   GPRFLN|            Tazunoki,T., Sawa,E., Nishitoba,T., Kamishohara,M., Kobayashi,E.,
CC   GPRFLN|            Kataoka,S. and Sato,T.
CC   GPRFLN|  TITLE     The molecular interaction of Fas and FAP-1. A tripeptide blocker of
CC   GPRFLN|            human Fas interaction with FAP-1 promotes Fas-induced apoptosis
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 272 (13), 8539-8545 (1997)
CC   GPRFLN|  MEDLINE   97236811
CC   GPRFLN|REFERENCE   12 (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Inazawa,J., Ariyama,T., Abe,T., Druck,T., Ohta,M., Huebner,K.,
CC   GPRFLN|            Yanagisawa,J., Reed,J.C. and Sato,T.
CC   GPRFLN|  TITLE     PTPN13, a fas-associated protein tyrosine phosphatase, is located
CC   GPRFLN|            on the long arm of chromosome 4 at band q21.3
CC   GPRFLN|  JOURNAL   Genomics 31 (2), 240-242 (1996)
CC   GPRFLN|  MEDLINE   96422192
CC   GPRFLN|REFERENCE   13 (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Sato,T., Irie,S., Kitada,S. and Reed,J.C.
CC   GPRFLN|  TITLE     FAP-1: a protein tyrosine phosphatase that associates with Fas
CC   GPRFLN|  JOURNAL   Science 268 (5209), 411-415 (1995)
CC   GPRFLN|  MEDLINE   95232528
CC   GPRFLN|REFERENCE   14 (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Saras,J., Claesson-Welsh,L., Heldin,C.H. and Gonez,L.J.
CC   GPRFLN|  TITLE     Cloning and characterization of PTPL1, a protein tyrosine
CC   GPRFLN|            phosphatase with similarities to cytoskeletal-associated proteins
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 269 (39), 24082-24089 (1994)
CC   GPRFLN|  MEDLINE   95014139
CC   GPRFLN|REFERENCE   15 (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Banville,D., Ahmad,S., Stocco,R. and Shen,S.H.
CC   GPRFLN|  TITLE     A novel protein-tyrosine phosphatase with homology to both the
CC   GPRFLN|            cytoskeletal proteins of the band 4.1 family and
CC   GPRFLN|            junction-associated guanylate kinases
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 269 (35), 22320-22327 (1994)
CC   GPRFLN|  MEDLINE   94350988
CC   GPRFLN|REFERENCE   16 (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Maekawa,K., Imagawa,N., Nagamatsu,M. and Harada,S.
CC   GPRFLN|  TITLE     Molecular cloning of a novel protein-tyrosine phosphatase
CC   GPRFLN|            containing a membrane-binding domain and GLGF repeats
CC   GPRFLN|  JOURNAL   FEBS Lett. 337 (2), 200-206 (1994)
CC   GPRFLN|  MEDLINE   94116679
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|JNA|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        4    275       VNTIFKEY:269
FT   PROTEIN       4    275       protein tyrosine phosphatase, nonreceptor type 13; protein tyrosine phosphatase 1E; Fas-associated phosphatase-1; protein-tyrosine phosphatase 1, Fas-associated; protein-tyrosine phophatase PTPL1; APO-1/CD95 (Fas)-associated phosphatase
FT                                VNTIFKEY:270
FT   REGION       20    274       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_2
SQ   SEQUENCE   275 AA;
     ANLKSVIRVL RGLLDQGIPS KELENLQELK PLDQCLIGQT KENRRKNRYK NILPYDATRV        60
     PLGDEGGYIN ASFIKIPVGK EEFVYIACQG PLPTTVGDFW QMIWEQKSTV IAMMTQEVEG       120
     EKIKCQRYWP NILGKTTMVS NRLRLALVRM QQLKGFVVRA MTLEDIQTRE VRHISHLNFT       180
     AWPDHDTPSQ PDDLLTFISY MRHIHRSGPI ITHCSAGIGR SGTLICIDVV LGLISQDLDF       240
     DISDLVRCMR LQRHGMVQTE DQYIFCYQVI LYVLT                                  275
//
ID   hPTPbeta_D1\(NP_002828)\PTPRB STANDARD;PRT;   280 AA.
AC   NP_002828;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, B precursor; protein tyrosine phosphatase, receptor type, beta polypeptide; protein tyrosine phosphatase beta [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from X54131.1 and BE042873.1.
CC   On Feb 4, 2002 this sequence version replaced gi:4506305.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP contains an extracellular
CC   domain, a single transmembrane segment and one intracytoplasmic
CC   catalytic domain, thus belongs to receptor type PTP. The
CC   extracellular region of this PTP is composed of multiple
CC   fibronectin type_III repeats, which was shown to interact with
CC   neuronal receptor and cell adhesion molecules, such as contactin
CC   and tenascin C. This protein was also found to interact with sodium
CC   channels, and thus may regulate sodium channels by altering
CC   tyrosine phosphorylation status. The functions of the interaction
CC   partners of this protein implicate the roles of this PTP in cell
CC   adhesion, neurite growth, and neuronal differentiation.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1997)
CC   GPRFLN|  AUTHORS   Adamsky,K., Schilling,J., Garwood,J., Faissner,A. and Peles,E.
CC   GPRFLN|  TITLE     Glial tumor cell adhesion is mediated by binding of the FNIII
CC   GPRFLN|            domain of receptor protein tyrosine phosphatase beta (RPTPbeta) to
CC   GPRFLN|            tenascin C
CC   GPRFLN|  JOURNAL   Oncogene 20 (5), 609-618 (2001)
CC   GPRFLN|  MEDLINE   21214455
CC   GPRFLN|REFERENCE   2  (residues 1 to 1997)
CC   GPRFLN|  AUTHORS   Ratcliffe,C.F., Qu,Y., McCormick,K.A., Tibbs,V.C., Dixon,J.E.,
CC   GPRFLN|            Scheuer,T. and Catterall,W.A.
CC   GPRFLN|  TITLE     A sodium channel signaling complex: modulation by associated
CC   GPRFLN|            receptor protein tyrosine phosphatase beta
CC   GPRFLN|  JOURNAL   Nat. Neurosci. 3 (5), 437-444 (2000)
CC   GPRFLN|  MEDLINE   20233995
CC   GPRFLN|REFERENCE   3  (residues 1 to 1997)
CC   GPRFLN|  AUTHORS   Sakurai,T., Lustig,M., Nativ,M., Hemperly,J.J., Schlessinger,J.,
CC   GPRFLN|            Peles,E. and Grumet,M.
CC   GPRFLN|  TITLE     Induction of neurite outgrowth through contactin and Nr-CAM by
CC   GPRFLN|            extracellular regions of glial receptor tyrosine phosphatase beta
CC   GPRFLN|  JOURNAL   J. Cell Biol. 136 (4), 907-918 (1997)
CC   GPRFLN|  MEDLINE   97201469
CC   GPRFLN|REFERENCE   4  (residues 1 to 1997)
CC   GPRFLN|  AUTHORS   Peles,E., Nativ,M., Campbell,P.L., Sakurai,T., Martinez,R., Lev,S.,
CC   GPRFLN|            Clary,D.O., Schilling,J., Barnea,G., Plowman,G.D. et al.
CC   GPRFLN|  TITLE     The carbonic anhydrase domain of receptor tyrosine phosphatase beta
CC   GPRFLN|            is a functional ligand for the axonal cell recognition molecule
CC   GPRFLN|            contactin
CC   GPRFLN|  JOURNAL   Cell 82 (2), 251-260 (1995)
CC   GPRFLN|  MEDLINE   95354206
CC   GPRFLN|REFERENCE   5  (residues 1 to 1997)
CC   GPRFLN|  AUTHORS   Harder,K.W., Anderson,L.L., Duncan,A.M. and Jirik,F.R.
CC   GPRFLN|  TITLE     The gene for receptor-like protein tyrosine phosphatase (PTPRB) is
CC   GPRFLN|            assigned to chromosome 12q15-->q21
CC   GPRFLN|  JOURNAL   Cytogenet. Cell Genet. 61 (4), 269-270 (1992)
CC   GPRFLN|  MEDLINE   93137605
CC   GPRFLN|REFERENCE   6  (residues 1 to 1997)
CC   GPRFLN|  AUTHORS   Krueger,N.X., Streuli,M. and Saito,H.
CC   GPRFLN|  TITLE     Structural diversity and evolution of human receptor-like protein
CC   GPRFLN|            tyrosine phosphatases
CC   GPRFLN|  JOURNAL   EMBO J. 9 (10), 3241-3252 (1990)
CC   GPRFLN|  MEDLINE   91006018
CC   GPRFLN|REFERENCE   7  (residues 1 to 1997)
CC   GPRFLN|  AUTHORS   Kaplan,R., Morse,B., Huebner,K., Croce,C., Howk,R., Ravera,M.,
CC   GPRFLN|            Ricca,G., Jaye,M. and Schlessinger,J.
CC   GPRFLN|  TITLE     Cloning of three human tyrosine phosphatases reveals a multigene
CC   GPRFLN|            family of receptor-linked protein-tyrosine-phosphatases expressed
CC   GPRFLN|            in brain
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (18), 7000-7004 (1990)
CC   GPRFLN|  MEDLINE   90384936
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    280       VNTIFKEY:269
FT   PROTEIN       1    280       protein tyrosine phosphatase, receptor type, beta polypeptide; protein tyrosine phosphatase beta
FT                                VNTIFKEY:270
FT   CHAIN         1    280       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       17    280       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   280 AA;
     NQFEGHFMKL QADSNYLLSK EYEELKDVGR NQSCDIALLP ENRGKNRYNN ILPYDATRVK        60
     LSNVDDDPCS DYINASYIPG NNFRREYIVT QGPLPGTKDD FWKMVWEQNV HNIVMVTQCV       120
     EKGRVKCDHY WPADQDSLYY GDLILQMLSE SVLPEWTIRE FKICGEEQLD AHRLIRHFHY       180
     TVWPDHGVPE TTQSLIQFVR TVRDYINRSP GAGPTVVHCS AGVGRTGTFI ALDRILQQLD       240
     SKDSVDIYGA VHDLRLHRVH MVQTECQYVY LHQCVRDVLR                             280
//
ID   hPTPD1_D1\(NP_008970)\PTPN21 STANDARD;PRT;   292 AA.
AC   NP_008970;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, non-receptor type 21; protein tyrosine phosphatase D1 [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from X79510.1 and AI800682.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP contains an N-terminal domain,
CC   similar to cytoskeletal- associated proteins including band 4.1,
CC   ezrin, merlin, and radixin. This PTP was shown to specially
CC   interact with BMX/ETK, a member of Tec tyrosine kinase family
CC   characterized by a multimodular structures including PH, SH3, and
CC   SH2 domains. The interaction of this PTP with BMX kinase was found
CC   to increase the activation of STAT3, but not STAT2 kinase. Studies
CC   of the similar gene in mice suggested the possible roles of this
CC   PTP in liver regeneration and spermatogenesis.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1174)
CC   GPRFLN|  AUTHORS   Jui,H.Y., Tseng,R.J., Wen,X., Fang,H.I., Huang,L.M., Chen,K.Y.,
CC   GPRFLN|            Kung,H.J., Ann,D.K. and Shih,H.M.
CC   GPRFLN|  TITLE     Protein-tyrosine phosphatase D1, a potential regulator and effector
CC   GPRFLN|            for Tec family kinases
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 275 (52), 41124-41132 (2000)
CC   GPRFLN|  MEDLINE   20576274
CC   GPRFLN|REFERENCE   2  (residues 1 to 1174)
CC   GPRFLN|  AUTHORS   Tokuchi,H., Higashitsuji,H., Nishiyama,H., Nonoguchi,K., Nagao,T.,
CC   GPRFLN|            Xue,J.H., Itoh,K., Ogawa,O. and Fujita,J.
CC   GPRFLN|  TITLE     Expression of protein tyrosine phosphatase PTP-RL10 and its isoform
CC   GPRFLN|            in the mouse testis
CC   GPRFLN|  JOURNAL   Int J Urol 6 (11), 572-577 (1999)
CC   GPRFLN|  MEDLINE   20049818
CC   GPRFLN|REFERENCE   3  (residues 1 to 1174)
CC   GPRFLN|  AUTHORS   Higashitsuji,H., Arii,S., Furutani,M., Imamura,M., Kaneko,Y.,
CC   GPRFLN|            Takenawa,J., Nakayama,H. and Fujita,J.
CC   GPRFLN|  TITLE     Enhanced expression of multiple protein tyrosine phosphatases in
CC   GPRFLN|            the regenerating mouse liver: isolation of PTP-RL10, a novel
CC   GPRFLN|            cytoplasmic-type phosphatase with sequence homology to cytoskeletal
CC   GPRFLN|            protein 4.1
CC   GPRFLN|  JOURNAL   Oncogene 10 (2), 407-414 (1995)
CC   GPRFLN|  MEDLINE   95140431
CC   GPRFLN|REFERENCE   4  (residues 1 to 1174)
CC   GPRFLN|  AUTHORS   Moller,N.P., Moller,K.B., Lammers,R., Kharitonenkov,A., Sures,I.
CC   GPRFLN|            and Ullrich,A.
CC   GPRFLN|  TITLE     Src kinase associates with a member of a distinct subfamily of
CC   GPRFLN|            protein-tyrosine phosphatases containing an ezrin-like domain
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 91 (16), 7477-7481 (1994)
CC   GPRFLN|  MEDLINE   94329538
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    292       VNTIFKEY:269
FT   PROTEIN       1    292       protein tyrosine phosphatase D1
FT                                VNTIFKEY:270
FT   REGION       18    292       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_2
SQ   SEQUENCE   292 AA;
     ATNDERCKIL EQRLEQGMVF TEYERILKKR LVDGECSTAR LPENAERNRF QDVLPYDDAR        60
     VELVPTKENN TGYINASHIK VSVSGIEWDY IATQGPLQNT CQDFWQMVWE QGIAIIAMVT       120
     AEEEGGREKS FRYWPRLGSR HNTVTYGRFK ITTRFRTDSG CYATTGLKMK HLLTGQERTV       180
     WHLQYTDWPE HGCPEDLKGF LSYLEEIQSV RRHTNSTSDP QSPNPPLLVH CSAGVGRTGV       240
     VILSEIMIAC LEHNEVLDIP RVLDMLRQQR MMLVQTLCQY TFVYRVLIQF LK               292
//
ID   hPTPD2_D1\(NP_005392)\PTPN14 STANDARD;PRT;   292 AA.
AC   NP_005392;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, non-receptor type 14; cytoskeletal-associated protein tyrosine phosphatase [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from X82676.1 and BC017300.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP contains an N-terminal
CC   noncatalytic domain similar to that of band 4.1 superfamily
CC   cytoskeleton-associated proteins, which suggested the membrane or
CC   cytoskeleton localization of this protein. The specific function of
CC   this PTP has not yet been determined.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1187)
CC   GPRFLN|  AUTHORS   Wadham,C., Gamble,J.R., Vadas,M.A. and Khew-Goodall,Y.
CC   GPRFLN|  TITLE     Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to
CC   GPRFLN|            the nucleus is associated with induction of cell proliferation
CC   GPRFLN|  JOURNAL   J. Cell. Sci. 113 (Pt 17), 3117-3123 (2000)
CC   GPRFLN|  MEDLINE   20394014
CC   GPRFLN|REFERENCE   2  (residues 1 to 1187)
CC   GPRFLN|  AUTHORS   Aoyama,K., Matsuda,T. and Aoki,N.
CC   GPRFLN|  TITLE     Characterization of newly identified four isoforms for a putative
CC   GPRFLN|            cytosolic protein tyrosine phosphatase PTP36
CC   GPRFLN|  JOURNAL   Biochem. Biophys. Res. Commun. 266 (2), 523-531 (1999)
CC   GPRFLN|  MEDLINE   20068798
CC   GPRFLN|REFERENCE   3  (residues 1 to 1187)
CC   GPRFLN|  AUTHORS   Ogata,M., Takada,T., Mori,Y., Uchida,Y., Miki,T., Okuyama,A.,
CC   GPRFLN|            Kosugi,A., Sawada,M., Oh-hora,M. and Hamaoka,T.
CC   GPRFLN|  TITLE     Regulation of phosphorylation level and distribution of PTP36, a
CC   GPRFLN|            putative protein tyrosine phosphatase, by cell-substrate adhesion
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 274 (29), 20717-20724 (1999)
CC   GPRFLN|  MEDLINE   99329094
CC   GPRFLN|REFERENCE   4  (residues 1 to 1187)
CC   GPRFLN|  AUTHORS   Ogata,M., Takada,T., Mori,Y., Oh-hora,M., Uchida,Y., Kosugi,A.,
CC   GPRFLN|            Miyake,K. and Hamaoka,T.
CC   GPRFLN|  TITLE     Effects of overexpression of PTP36, a putative protein tyrosine
CC   GPRFLN|            phosphatase, on cell adhesion, cell growth, and cytoskeletons in
CC   GPRFLN|            HeLa cells
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 274 (18), 12905-12909 (1999)
CC   GPRFLN|  MEDLINE   99230323
CC   GPRFLN|REFERENCE   5  (residues 1 to 1187)
CC   GPRFLN|  AUTHORS   Smith,A.L., Mitchell,P.J., Shipley,J., Gusterson,B.A., Rogers,M.V.
CC   GPRFLN|            and Crompton,M.R.
CC   GPRFLN|  TITLE     Pez: a novel human cDNA encoding protein tyrosine phosphatase- and
CC   GPRFLN|            ezrin-like domains
CC   GPRFLN|  JOURNAL   Biochem. Biophys. Res. Commun. 209 (3), 959-965 (1995)
CC   GPRFLN|  MEDLINE   95251727
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    292       VNTIFKEY:269
FT   PROTEIN       1    292       cytoskeletal-associated protein tyrosine phosphatase
FT                                VNTIFKEY:270
FT   REGION       18    292       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_2
SQ   SEQUENCE   292 AA;
     VPMDERFRTL KKKLEEGMVF TEYEQIPKKK ANGIFSTAAL PENAERSRIR EVVPYEENRV        60
     ELIPTKENNT GYINASHIKV VVGGAEWHYI ATQGPLPHTC HDFWQMVWEQ GVNVIAMVTA       120
     EEEGGRTKSH RYWPKLGSKH SSATYGKFKV TTKFRTDSVC YATTGLKVKH LLSGQERTVW       180
     HLQYTDWPDH GCPEDVQGFL SYLEEIQSVR RHTNSMLEGT KNRHPPIVVH CSAGVGRTGV       240
     LILSELMIYC LEHNEKVEVP MMLRLLREQR MFMIQTIAQY KFVYQVLIQF LQ               292
//
ID   hPTPdelta\_D1\(NP_002830)\PTPRD STANDARD;PRT;   275 AA.
AC   NP_002830;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, D isoform 1 precursor; protein tyrosine phosphatase, receptor type, delta polypeptide; protein tyrosine phosphatase delta [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from L38929.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to