CLUSTAL X (1.81) multiple sequence alignment SHP2 CGGCCCCAGGCCTGGAG-GGGGGTCTGTGCGCGGCCGGCTGGCTCTGCC-CCGCGTCCGG hSHP2-P3 ----CCCAGGCCTGGAG-TGGGGTCCGTGCATGGCCAGCTGGCTCTGCC-CCACGGCCAG hSHP2-P4 ------------------------------------------------------------ hSHP2-P5 --TCCCCAGGCCTGGAGAGGGGGTCTGTGCACAGCCGGCTGGCTCTGTCTCCTCGTCTGG hSHP2-P6 ------------------------------------------------------------ hSHP2-P8 -ATCCCCAGGCCTGGAG-GGGGGTCTGTGCACAGTCGGCTGGCTCCGCC-CCGCATCTGG SHP2 TCCCGAGCGGGCCTCCCTCGGGCCAGCCCGATGTGACCGAGCCCAGCGGAGCCTGAGCAA hSHP2-P3 TCCTGAGCAGGCCTCCCTTGGGCCAGCCCGATGTGACTGAGCCCAGCAGACCCTGAGCAA hSHP2-P4 ------------------------------------------------------------ hSHP2-P5 TCCCGAGTAGGCCTCCCTTGGGCTAGCCCGATGTGACCCAGCCCAGTGGAGCCTGAGCAA hSHP2-P6 ------------------------------------------------------------ hSHP2-P8 TCCCGAGCGGGCCTCCCTCGGGCCAGCCCAACGTGACCGAGCCCAGTGGAGCCTGAGCAA SHP2 GGAGCGGGTCCGTCGCGGAGCCGGAGGGCGGGAGGAACATGACATCGCGGAGATGGTTTC hSHP2-P3 GAAGCAGGTCCATCGCGGAGCCAGAGGGCAGGAGGAACATGACATCATGGAAATGGTTTC hSHP2-P4 ------------------------------------------------------------ hSHP2-P5 GCAGCGGGTCCGTCACAGAGCTGGAGGGCGGGAGGAACATGACATCGCGGAGATGGTTTC hSHP2-P6 ----------------------------------------------------ATGGTTTC hSHP2-P8 GGAACGGGTCTGTCACGGAGCCGGAATGTGGGAGGAACATGACATTGTAGAGATGGTTTC SHP2 ACCCAAATATCACTGGTGTGGAGGCAGAAAA-CCTACTGTTGACAAGAGGAGTTGATGGC hSHP2-P3 ACCCAAATATCACTGGTGTGGAGGCAGAAAA-CCTACTGTTGACAAGAGGAGTTGATGGC hSHP2-P4 ------------------------------------------------------------ hSHP2-P5 ACCCAAATATCACTGGTGTGGAGGCAGAAAA-CCTACTGTTGACAAGAGGAGTTGATGGC hSHP2-P6 ACCCAAATATCAGTGGTGTGGAGGCAGAAAAACCTATTGTCGACAAGAGGAGTTGATGGC hSHP2-P8 ACCCAAATATCACTGGGGTGGAGGCAGAAAA-CCCACTGTTGATAAGAGGAGCTGACAGC SHP2 AGTTTTTTGGCAAGGCCTAGTAAAAGTAACCCTGGAGACTTCACACTTTCCGTTAGAAGA hSHP2-P3 AGTTTTTCGGCAAGGCCTAGTAAAAGTAACCCTGGAGACGTCACACTTTCTGTTAGAAGA hSHP2-P4 ------------------------------------------------------------ hSHP2-P5 AGTGTTTTGGCAAGGCCTAATAAAAGTAACCCTGGAGACTTCACACTTTCCATTAGAAGA hSHP2-P6 AGTTTTTTGGCAAGGCCTAGTAAAAGTACCCCTGGAGACTTCACATGTTCCATTAGAAGA hSHP2-P8 AGTTTTTTGGCAAGGCCTAGTAAAAGTAACCCTGGAGACTTCACACTTTTTGTTAGAAGA SHP2 AATGGAGCTGTCACCCACATCAAGATTCAGAACACTGG---------------------- hSHP2-P3 AATGGAGCTGTCACCCACACCAAGATTCAGAACACTGG---------------------- hSHP2-P4 ------------------------------------------------------------ hSHP2-P5 AATGGAGCTGTCACCCACA------TTTAGAGCACTGG---------------------- hSHP2-P6 AATAGAGCTGTCACCCACATCAAGATTCAGAACACTGG---------------------- hSHP2-P8 AATGGAGCTGTCACCCACATCAAGATTCAGAACACTGGGCCGGTCACGGTGGTTCACACC SHP2 ------------------------------------------------------------ hSHP2-P3 ------------------------------------------------------------ hSHP2-P4 ------------------------------------------------------------ hSHP2-P5 ------------------------------------------------------------ hSHP2-P6 ------------------------------------------------------------ hSHP2-P8 TGTAATCCCAGCACTTTGGGAGGCTGAGGAGGGCGGATCACAAAGTCAGGAGATTGAGAC SHP2 ------------------------------------------------------------ hSHP2-P3 ------------------------------------------------------------ hSHP2-P4 ------------------------------------------------------------ hSHP2-P5 ------------------------------------------------------------ hSHP2-P6 ------------------------------------------------------------ hSHP2-P8 CATCCTGGCTAACATGGTGAAACCCCGTCTCTACTAAAAAATACAAAAAAATTAGCCGGG SHP2 ------------------------------------------------------------ hSHP2-P3 ------------------------------------------------------------ hSHP2-P4 ------------------------------------------------------------ hSHP2-P5 ------------------------------------------------------------ hSHP2-P6 ------------------------------------------------------------ hSHP2-P8 CATGGTGGCAGGCACCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATGGCATG SHP2 ------------------------------------------------------------ hSHP2-P3 ------------------------------------------------------------ hSHP2-P4 ------------------------------------------------------------ hSHP2-P5 ------------------------------------------------------------ hSHP2-P6 ------------------------------------------------------------ hSHP2-P8 AACCCAGCAGGCGGAGCTTACAGTGAGCCGAGATCATGCCACTGCACTCCAGCCTGGGTG SHP2 ---------------------------------------------------------TGA hSHP2-P3 ---------------------------------------------------------TGA hSHP2-P4 ------------------------------------------------------------ hSHP2-P5 ---------------------------------------------------------TGA hSHP2-P6 ---------------------------------------------------------TGA hSHP2-P8 ACAGAGCGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAGATTCAGAACACTGGTGA SHP2 TTACTATGACCTGTATGGAGGGGAGAAATTTGCCACTTTGGCTGAGTTGGTCCAGTATTA hSHP2-P3 TTGCTATGACCTGTATGGAGGGGAGAAGTTTGCCACTTTGGCTGAGTTGGTCCAGTATTA hSHP2-P4 ------------------------------------------------------------ hSHP2-P5 TTACTATGACCTCTATGGAGAGGAGAAATGTGCCACTTTGGCTGAGTTGGTCCAGTATTA hSHP2-P6 TTACTAGGACCCGTTTGG-GGGGAAAAGTTTGCCACTTCGGCTGAGTTGGTCCAGTATTA hSHP2-P8 TTACTGTGATCTGTGTGGAGGGGAGAAATTTTCCACTTTGGCTGAGTTGGTCCGGCATTA SHP2 CATGGAACATCACGGGCAATTAAAAGAGAAGAATGGAGATGTCATTGAGCTTAAATATCC hSHP2-P3 CATGGAACATCATGGGCAATTAAAAGAGAAGAATGGAGATGTTATTGAGCTTAAAAATCC hSHP2-P4 ------------------------------------------------------------ hSHP2-P5 CATGGAACATCATAGGCAATTAAAAGAGAAGAATGGAGATGTTATTGAGCTTAAATATCT hSHP2-P6 CATGGAACATCACAGGCAATTAAAAGAGAAGAATGGAGATGTTGTTGAGCTTAAATATCC hSHP2-P8 CACAGAACATCACGGGCAATTAAAAGAGAAGAATGGAGATGTTATTGAGCTTAAATATCC SHP2 TCTGAACTGTGCAGATCCTACCTCTGAAAGGTGGTTTCATGGACATCTCT-CTGGGAAAG hSHP2-P3 TCTGAACTGTGCAGATCCTACTTCTCAAAGGTGGTTTCATGGACACCTCT-CTGGAAAAG hSHP2-P4 ------------------------------------------------------------ hSHP2-P5 TCTGAACTGTGCAGATTATACCTCTGAAAGG----------------------------- hSHP2-P6 TCTGAACTGTGCGGATCCTGCCTCTGAAAGATGGTTTCACGGACACCTCTT-TGGGAAAG hSHP2-P8 TCTGAACTGTGCAGATCCTGCCTCTGAAAGGTGGTTTCAGGGACACCTCT-CTGGGAAAG SHP2 AAGCAGAGAAATTATTAACTGAAAAAGGAAAACATGGTAGTTTTCTTGTACGAGAGAGCC hSHP2-P3 AAGCAGAGAAATTGTTAACTGAAAAAGGAAAGCATAGTAGCTTTCTTGTACGAGAGAGCC hSHP2-P4 ------------------------------------------------------------ hSHP2-P5 ------------------------------------------------------------ hSHP2-P6 AAGCAGAGAAATTA---ACTGAAAAAGGAAAACATGGTAGCTTTCTTATACGAGAGAGCC hSHP2-P8 AAGCAGAGAAATTATTAACTGAAAAAGGAAAACATGGTAGTTTTCTTGTATGAGAGAGCC SHP2 AGAGCCACCCTGGAGATTTTGTTCTTTCTGTGCGCACTGGTGATGACAAAGGGGAGAGCA hSHP2-P3 AGAGCCACCCTGGAGATTTTGTTCTCTCCGTGTGCACCGGTGATGACAAAGGAGAGAGCA hSHP2-P4 ------------------------------------------------------------ hSHP2-P5 ------------------------------------------------------------ hSHP2-P6 AGAGCCACCCTGGAGATTTTGTTCTCTCTGTGCGCACCAGTGATGACAAAAAAGAGAGCA hSHP2-P8 AGAGCCACCTTGGAGATTTTGTTCTCTCTGTGCGCACCAGTGATGACAAAGGGGAGAACA SHP2 ATGACGGCAAGTCTAAAGTGACCCATGTTATGATTCGCTGTCAGGAACTGAAATACGACG hSHP2-P3 ATGACGGCAAGTCTAAAGTGACTCATGTCATGATTCACTGTCAGGAACTGAAATACGATG hSHP2-P4 -----------------------------ATGATTCGTTGTCAGGAATTGAAATACAACA hSHP2-P5 ---------------------------------------------AACTGAAATATGACG hSHP2-P6 ATGACAGCAAGTGTAAAGTGACCCATGTCATGATTCGCTGTCAGGAACTGAAATACGACG hSHP2-P8 ATAACGGCAAGTCTAAAGTGGCCCATGTTATGATTTGCTGTCAGGAACTGAAATACGATG ** ******* * SHP2 TTGGTGGAGGAGAACGGTTTGATTCTTTGACAGATCTTGTGGAACATTATAAGAAGAATC hSHP2-P3 TTGGTGGAGGAGAACGGTTTGATGCTTTGACAGATCTT-TGGAACATTAGAAGAAGAATC hSHP2-P4 TTGGTGGAGGAGAACGGTTTGATTCTTTGACAGATCTTGTGGAGCATTACAAGAAGAATC hSHP2-P5 TTGGTGGAGGAGAACGGTTTGATTCTTTAACAGATCTTGAAGAACATTACAAGAAGAATT hSHP2-P6 TTGGTGGAGGAAAACGGTTTGATTCTTTGACGGATCTCGTGGAACATTACAAGAAGAATC hSHP2-P8 TTGGTGGAGGAGAACGGTATGATTCTTTGACAGATCTTGTGGAACATTACAAGAAGAATC *********** ****** **** **** ** ***** ** ***** ********* SHP2 CTATGGTGGAAACATTGGGTACAGTACTACAACTCAAGCAGCCCCTTAACACGACTCGTA hSHP2-P3 CTATGGTGGAAACACTGGGTACAGTACTACAACTCAAGCAGCCCCTTAACACGACTTGTA hSHP2-P4 TAATGGTGGAAACATTGGGTACAGTACTACAACTCAAGCAGCCCCTTAACATAACTTGTA hSHP2-P5 CCATGGTGGAAACCTTGGGTACAGTACTACAACTCAAGCATCCCCTTAACACGACTCATA hSHP2-P6 CTATGCTGGAAACATTGGGTACAGTACTACGACTCAAGCAGCCCCTTAACATGACTCGTA hSHP2-P8 CTATGATGGAAACATGGGGTACAGTACTACAACTCACGTAGCCCCTTAACACGACTCGTA *** ******* ************** ***** * * ********** *** ** SHP2 TAAATGCTGCTGAAATAGAAAGCAGAGTTCGAGAACTAAGCAAATTAGCTGAGACCACAG hSHP2-P3 CAAATGCTGCTGAAATAGAAAGCAGAGTTCGAGAACTAAGCAAATTAGCTGAGACCACAG hSHP2-P4 TAAATGCTGCTGAAATAGAAAGCAGAGTTCGAGAACTAAGCAAATTAGCTGAGACCACAG hSHP2-P5 TAAATGCTGCTGAAATAAAAAGCAGAGTTCGAGAACTAAGCAAATTAGCTGAGACCACAG hSHP2-P6 TAAATGCTGCTGAAATAGAAAGCAGAGTTTGAGAACTAAGCAAATTAGCTGAGACCACAG hSHP2-P8 TAAATGTTGCTGAAATAG----CAGAATTCGAGAACTAAGCAAATTAGCTGAGACCACA- ***** ********** **** ** ***************************** SHP2 ATAAAGTCAAACAAGGCTTTTGGGAAGAATTTGAGACACTACAACAACAGGAGTGCAAAC hSHP2-P3 ATAAAGTCAGACAAGGCTTTTGGGAAGAATTTGAGACACTGCAACAACAGGAGTGCAAAC hSHP2-P4 ATAAAGTCAAACAAGGCTTTTGGAAAGAATTTGAGACACTGCAACAACAGGAGTGCAAAC hSHP2-P5 ACAAACTCAAACAAGGCTTTTGGGAAAAATTTGAGACACTACAACAACAGGAGTGCAAAC hSHP2-P6 ACAAAGTCCAACAAGGCTTTTGGGAAGAATTTGAGACACTACAACCACAGGAGTGCAAAC hSHP2-P8 ATAAAGTCAAACAAGGCTTTTCGGAAGAATTTGAGACACTACAACAACAGGAGTGCATAC * *** ** *********** * ** ************* **** *********** ** SHP2 TTCTCTACAGCCGAAAAGAGGGTCAAAGGCAAGAAAACAAAAACAAAAATAGATATAAA- hSHP2-P3 TTCTCTACAGCCAAAAAGAGGGTCGAAGGCAAGAAAACAAAACCAAAAATAGATATAAAG hSHP2-P4 TTCTCTACAGCTGAAAAGAGGGTCAAAGGCAAGAAAATAAAAACAAAAATAGATATTAA- hSHP2-P5 TTCTCTACAGCCGAAAAGAGGGTCAAAGGCAAGAAAACAAAAACAAAAATAGATATAAA- hSHP2-P6 TTCTCTACAGCCGAAAAGAGGGTCAAAGGCAAGAAAACAAAAACAAAAATAGATATAAA- hSHP2-P8 TTCTCTACGGCCGAAAAGAGGGTAAAAGGCAAGAAAACAAAAACAAAAATAGATATAAA- ******** ** ********** ************ **** ************* ** SHP2 ------------------------------------------------------------ hSHP2-P3 GCCGGGCGCGGTAGCTCACGCCTTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGCAGA hSHP2-P4 ------------------------------------------------------------ hSHP2-P5 ------------------------------------------------------------ hSHP2-P6 ------------------------------------------------------------ hSHP2-P8 ------------------------------------------------------------ SHP2 ------------------------------------------------------------ hSHP2-P3 TCACAAGGTCAGGAGATCGAGACCACCCTGGCCAACACGGTGAAACCCCCTCTCTACTAA hSHP2-P4 ------------------------------------------------------------ hSHP2-P5 ------------------------------------------------------------ hSHP2-P6 ------------------------------------------------------------ hSHP2-P8 ------------------------------------------------------------ SHP2 ------------------------------------------------------------ hSHP2-P3 AAATACAAAAATTAGCCGGGCGTGGTGGCACACCCCTGTAATCCCAGCTACTAGGGAGGC hSHP2-P4 ------------------------------------------------------------ hSHP2-P5 ------------------------------------------------------------ hSHP2-P6 ------------------------------------------------------------ hSHP2-P8 ------------------------------------------------------------ SHP2 ------------------------------------------------------------ hSHP2-P3 TGAGGCAGGAGAATGGCGTGAACCCGAGAGTCAGAGGTTGCAGTGAGCCAAGATCACCAC hSHP2-P4 ------------------------------------------------------------ hSHP2-P5 ------------------------------------------------------------ hSHP2-P6 ------------------------------------------------------------ hSHP2-P8 ------------------------------------------------------------ SHP2 ------------------------------------------------------------ hSHP2-P3 TGCACTCCAGGCTGGGCGACTGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAGA hSHP2-P4 -----------------------------------------------------------A hSHP2-P5 ------------------------------------------------------------ hSHP2-P6 ------------------------------------------------------------ hSHP2-P8 ------------------------------------------------------------ SHP2 -----------AACATCCTGCCCTTTGATCATACCAGGGTTGTCCTACACGATGGTGATC hSHP2-P3 TATAAAAACAAAACATCCTGCCCTTTGATCATA---GGGTTGTCCTACACAATGGTGATC hSHP2-P4 -----------AACATCCTGCCCTTTGATAATACCAAGGTTGTTCTACATGACGG-GATC hSHP2-P5 -----------AACATCCTACCCTTTGATCATACTAGGGTTGTCCTACACGACGGTGATC hSHP2-P6 -----------AACATCCTGCCCTTTGATCATACCAGGGTTGTCCTACACGATGATGATC hSHP2-P8 -----------AATAACCTGCCCTTTGATCATACCAGGGTTGTCCTACACGATGGTGATC ** * *** ********* *** ****** ***** * * **** SHP2 CCAATGAGCCTGTTTCAGATTACATCAATGCAAATATCATCATGCCTGAATTTGAAACCA hSHP2-P3 CCAGTGAGGCTGTTTCAGATTACATCAACGCAGATATCATCATGCCTGAATTTGAAACCA hSHP2-P4 CCAATGAGCCTGTTTCAGGTTACATCAATGCAAATATCATCATGCCTGAATTTGAAACCA hSHP2-P5 CCGATGAGCCTGTTTCAGATTACATCAGTGCAAATACCATCATGCCTGAATTTGAAACCA hSHP2-P6 CCAATGAGCCTATTTCAGATTACATCAGTGCAAACACCATCATGCCTGAATTTGAAACCA hSHP2-P8 CCAACGAGCCTGTTTCAGATGACATCAATGCAAATATCATCATGCCCAAATTTGAAACCA ** *** ** ****** * ****** *** * * ********* ************ SHP2 AGTGCAACAATTCAAAGCCCAAAAAGAGTTACATTGCCACACAAGGCTGCCTGCAAAACA hSHP2-P3 AGTGCA-CAATTTGTAGCCCAAAAAGAGTTACATTGCCCCACAAGGCTGCCTGCAAAACA hSHP2-P4 AGTGCAACAATTCAAAGCCCAAAAAGAGTTACATTGCCACACAAGGCTGCCTACAAAACA hSHP2-P5 GGTGCAACAATTCAAAGCCCAAAACGTGTTACATTGCCACACAAGGCTGTCAGCAAAACA hSHP2-P6 AGTGCAACAATTCAAAACCCAAAAAGAGTTGCATTGCCACACAAGGCTGCCTGCAAAACA hSHP2-P8 AGTGTAACAATTCAAAGCCCAAGAAGAGTTACATTGCCACACAAGGCTGCCTGCAAAACA *** * ***** * ***** * * *** ******* ********** * ******* SHP2 CGGTGAATGACTTTTGGCGGATGGTGTTCCAAGAAAACTCCCGAGTGATTGTCATGACAA hSHP2-P3 CTGTGAATGACTTTTGGCGGATAGTGTTCCAAGAAAACTCCCAGGTGATTGTCATGACAA hSHP2-P4 CAGTGAACGACTTTTGGCGGATGGTTTTCCAA---AACTCCAGACTGATTGTCATGACAA hSHP2-P5 CAGTGAATGACTTTTGGCAGATGAAGTTCCAAGAAAACTCCCGAGTGATTGTCATGACAA hSHP2-P6 TGGTGAATGACTTTTGCTGGATGGTGTTCCAAGAAAACTCCCAAGTGATTGTCATGACAA hSHP2-P8 TGGTGAACGACTTTTGGCGGATGGTATTCCAAGAAAACTCCTGAGTGATTGTCATGACAA ***** ******** *** ****** ****** *************** SHP2 CGAAAGAAGTGGAGAGAGGAAAGAGTAAATGTGTCAAATACTGGCCTGATGAGTATGCTC hSHP2-P3 CGAAAGAAGTGGAGAGAGGAAAGAGTAAATGTGTCAAATACTGGCCCGATGAGTATGCTC hSHP2-P4 TGAAAGAAGCGGAGAGAGGAAAGAGTAAATGTGTCAAATACTGGCCTGATGAGTATGCTC hSHP2-P5 CAAAAGAAGTGGATAGAGGAAAGAGTAAATGTGTCAAATACTGGCCTGATGAGTATGCTT hSHP2-P6 TGAAAGAAATGGAGAGAGGAAAGAGTAAATGTGTCAAATACTGGTCTGAAGAGGATGCTC hSHP2-P8 CGAAAGAAGTGGAGAGAGGATAGAGTAAATGTGTCAAATACTGGCCTGATGAGTATGCTC ****** *** ****** *********************** * ** *** ***** SHP2 TAAAAGAATATGGCGTCATGCGTGTTAGGAACGTCAAAGAAAGCGCCGCTCATGACTATA hSHP2-P3 TAAAAGAATATGGCATCGTGCATGTTAGGAACGTCAAAGAAAGCACCACTCATGACTATA hSHP2-P4 TAAAAGAATATGGCGTCATGCGTGTTAGGAACGTCAAAGAAAGCGCCGCTCATGACTATA hSHP2-P5 TAAAAGAATATGGCGTCATGCGTGTTAGGAACGTCAAAGAAAGCGCAGCTCATGACTATA hSHP2-P6 TACAAGAATATGGGGTCATGTGTGTTAGGAACATCAAAGGAAGTGCTGTTCATGACTATA hSHP2-P8 TAAAAGAATATGGCATCATGCGTGTTAGGAATATCAGAGAAAGCACCGCTCACAACTATA ** ********** ** ** ********* *** ** *** * *** ****** SHP2 CGCTAAGAGAACTTAAACTTTCAAAGGTTGGACAAG------------GGAATACGGAGA hSHP2-P3 AGCTAAGAAAACTTAAACTTTCAAAGATTGGACAAG------------GGAATATGGAGA hSHP2-P4 CGCTAAGAGAACTTAAACTTTCAAAGGCTGGAGAAG------------GGAATTCGGAGA hSHP2-P5 CACTAAGAGAACTTGAACTTTCAAAGATTGGACCAG------------GGAATATGGAGA hSHP2-P6 TGCTAAGAGAACTTAAGTTTTCAAAGGTTGGACAAGCTGTACTCCAGGGGAATATGGCGA hSHP2-P8 TGCTAAGAGAACTTAAACTTTCAAAGGTTGGGCAAG------------GGAATATGGAGA ****** ***** * ******** *** ** ***** ** ** SHP2 GAACGGTCTGGCAATACCACTTTCGGACCTGGCCGGACCACGGCGTGCCCAGCGACCCTG hSHP2-P3 GAATGGTCTGGCAATACCACTTGTGGACCTGGCTGTACCACGGAGTGCCCTGCGACCCCA hSHP2-P4 GAACAGTCTGACAATACCACTTTCGGACCTGGGCGGACCACGGAGTGCTCAGCAACCCCG hSHP2-P5 GACCGGTCGGGCAATATCACTTTCGGACCTGGCCGGACCATGGAGTGCCCAGCGACCCCG hSHP2-P6 GAACGGTCTGGCAATACCACTTTCGGACCTGACCAGACCACGGAGTGCCCAGTGACCCCG hSHP2-P8 GAATGGTCTGGCAATACCACTTTTGGACCTGGCCGGACCACGGAGTGCCCATTGACCCCA ** *** * ***** ***** ******* **** ** **** * **** SHP2 GGGGCGTGCTGGACTTCCTGGAGGAGGTGCACCATAAGCAGGAGAGCATCATGGATGCAG hSHP2-P3 AAGGCATGCTGCACTTCCTGGACGAAGTGCACCATAAGCAGGAGAGCATCATGGATGCAG hSHP2-P4 GGGGTGTGCTGGACCTCCTGGAGAAGGTGCACCATAAGCAGGAGAGCATCATGGATGCAG hSHP2-P5 GGGTCGTGCTGGACTTCCTGGAGGAGGTGTACCATAAGCAGGGGAGCATCACGGATGCAG hSHP2-P6 GGGGCATGCTGGACTTCCTGGAGGAGGTGCACCATAAGCAGGAGAGCATCATGGATGCAG hSHP2-P8 GGGGTGTGCTGGACTTCCTGGAGGAGGTGCACCATAAGCAGGAACGCATCATGCATGCAA * ***** ** ******* * *** ************ ****** * ***** SHP2 GGCCGGTCGTGGTGCACTGCAGTGCTGGAATTGGCCGGACAGGGACGTTCATTGTGATTG hSHP2-P3 GGCTGGTCGTGGTGCCCTGCAGTGCTGGCATTGGCCAGACAGGGACGTTCATTGTGATTG hSHP2-P4 GGCCGGTCTTGGTGCACTGCAGTGCTGGAATTGGCCGGACAGGGACGTTCATTGTGATTG hSHP2-P5 GGCCGGTCGTGGTGCACTGTAGTGCTGGAATTGGCCTGACAGGGACGTTCATTGTGATTG hSHP2-P6 GGCTGGTCGTGGTCCACTGCAGTGCTGGAATTGGCCATACAGGGAGGTTCATTGTGATTA hSHP2-P8 GGCCAGTCGTGGTGCACGGCAGTGCTGGAATTGGCCGGACAGGGACATACGTTGTGATTG *** *** **** * * * ******** ******* ******* * * ******** SHP2 ATATTCTTATTGACATCATCAGAGAGAAAGGTGTTGACTGCGATATTGACGTTCCCAAAA hSHP2-P3 ATATTCTTATTGACATCATCAGAGAGAAAGGTGTTGACTGCGAAATTGACGTTCCCAAAA hSHP2-P4 ATATTCTTATTGACATCATCAGAGAGAA-GGTGTTGACTGCGACGTTGATGTTCCCCAAA hSHP2-P5 ATATTCTTACTGACATCGTCAGAGAGAAAGGTGTTGACTGCAACATTGACGTTCCCAAAA hSHP2-P6 ATAGTCTTATTGACATCATCAGAGAGAAAGGTATTAACTGCAACATTGACCTTCTCAAAA hSHP2-P8 ATATTCTGACTGACATCAACAGAGAGAAAGGTGTTGACTGCAACATTGACGTTCTCAAAA *** *** * ******* ********* *** ** ***** * **** *** * *** SHP2 CCATCCAGATGGTGCGGTCTCAGAGGTCAGGGATGGTCCAGACAGAAGCACAGTACCGAT hSHP2-P3 CCATCCAGATGGTGCGGTCTCAGAGGTCAGAGATGGTCCAGACAGAAGCACAGTACCGAT hSHP2-P4 CCATCCAGATGGTGTGGTCTACGAGGTCAGGGATGGTCCAGACAGAAGCACGGTACCGAT hSHP2-P5 CCATCCAGATGATGCGGTCTCAGAGGTCAGGGATGGTCCAGACAGAAGCATAGTACCGAT hSHP2-P6 CCATCCACACAGTGCAGTCTCAGAGGTCAGGGATGGCCCAGACAGAAGCACAGTACCGAT hSHP2-P8 CTATCCAGATGGTGCAGTCTCAGAGGTCAGGGATGGTCCAGACAGAAACACAGTACCGAT * ***** * ** **** ******** ***** ********** ** ******** SHP2 TTATCTATATGGCGGTCCAGCATTATATTGAAACACTACAGCGCAGGATTGAAGAAGAGC hSHP2-P3 TTATCTATACGGTGGTCCAGCATCATATTGAAACACTACAGCGCAGGATTGAGGAAGAGC hSHP2-P4 TTATCTATATGGCGGTCCAGCATTATATTGAAACACTACAGCGCAGGATTGAACAAAAGC hSHP2-P5 TTATCTATACGGCAGTCCAGCATTATATTGAAACACTGCAGCTCAGGATTGAAGAAGAGC hSHP2-P6 TTATCTATATGGCAGTCCAGCATTATATTGAAACACTACAGCACAAGATTGAAGAAGAGC hSHP2-P8 TTATCTATATGGCGGTCCAGCATTATACTGAAACACTACAGCGCAGGATTGAAGAAGAGC ********* ** ********* *** ********* **** ** ****** ** *** SHP2 AGAAAAGGAAGAGGAAAGGGCACGAATATACAAATATTAAGTATCCTCTAGCGGACCAGA hSHP2-P3 AGAAAAGCAAGAGGAAAGGGCACGAATATACAAATATTAAGTATTCTCTAGTGGACCAGA hSHP2-P4 AGAAAAGCAAGAGGAAAGGGCATGAATATATAAATATTAAGTATCCTCTAGCGGACCAGA hSHP2-P5 AAAAAAGCAAGAGGAAAGGGCACGAATATATAAATATTAAGTATTCTCTAGCGGACCAGA hSHP2-P6 AGAAAAGCAAGAGGAAAGGGCACGAATATAAAAATATTAAGTATTCTCTAGCAGACCAGA hSHP2-P8 AGAAAAGCAAGAGGAAAGGTCATGAATATACAAATATTAAGTATTCTCTAGCGGACCAGA * ***** *********** ** ******* ************* ****** ******* SHP2 CGAGTGGAGATCAGAGCCCTCTCCC--GCCTTGTACTCCAACGCCACCCTGTGCAGAAAT hSHP2-P3 CGAGTGGGGATCAGAGCCCCCTCCT--GCCTTATACTCCAATGCCACCCTGTGCAGAAAT hSHP2-P4 CGAGTGGAAATCAGAGCCCCCTCCC--GCCTTGTACTCCAAAGCCACCCTGTGCAGAAAT hSHP2-P5 AGAGTGGAGATCAGAGCCCCCTCCT--GCCTTGTACTCCAACGCCACCCTGTGCAGAAAT hSHP2-P6 CAAGTGGAGCCCAGAGCCCCCTCCC--GCCTTGCACTGCAGCGCCACCCTGTGCAGAAAT hSHP2-P8 CGAGTGGAGATCAGAGCCCCCCCCCCCGCCTTGTACTCCAACTCCACGCTGTGCAGAAAT ***** ******** * ** ***** *** ** **** ************ SHP2 GAGAGAAGACAGTGCTAGAGTCTATGAAAACGTGGGCCTGATGCAACAGCAGAAAAGTTT hSHP2-P3 GAGAGAAGAGAGTGCCAGAGTCTATGAAAACGTGGGCCTGATGCAACAGCAGAAACATTT hSHP2-P4 GAGAGGAGACAGTGCTAGAGTCTATGAAAACGTGGGCCTGATCCAACAGCAGAAAACTTT hSHP2-P5 GAGAGAAGACAGTGCTAGAGTCT--GAAAACGTGGGCCTGATGCAGCAGCAGAAAAGTTT hSHP2-P6 GAGAGAAGACAATGCTGGAGTCTGTGAAAACGTGGACCTGATACAACA---GAAAAGTTT hSHP2-P8 GAGAGCAGACAGTGCTAGAGTGTATGAAAACGTGGGCCTGATGCAACAGCAGAAGAGTTT ***** *** * *** **** * ********** ****** ** ** *** *** SHP2 CAGATGAGAAAACCTGCCAAAACTTCAGCACAGAAAT-----AGATGTGGACTTTCACCC hSHP2-P3 AAGATGAGAAAACCTGCCAAAACTTCAGCACAGAAAT-----AGATGTGGACTTTCACCC hSHP2-P4 CAGATGAGAAAACCTGCCAAAACTTCAGCACAGAAAT-----AGATGTGGACTTTCACCC hSHP2-P5 CAGATGAGAAAACCTGCCAAAACTTCAGCACAGAAAT-----AGAAGTGGACTTTCACCC hSHP2-P6 CACATGAGAAAACCTGG-AAAACTTCAGCACAGAAAGTCCACAGATGTGGACTTTCACCC hSHP2-P8 CAGATGAGAAAATCTGCCAAAACTTCAGCACAAAAAT-----AGATGTGGACTT-CACTC * ********* *** ************** *** *** ******** *** * SHP2 TCTCCCTAAAAAGATCAAGAACAGACGCAAGAAAGTTTATGTGAAGACAGAATTTGGATT hSHP2-P3 TCTCCCTAAAAAGATCAAGAGCAGACGCAATAAAGTTTATGTGAAGACAGAATTTGGATT hSHP2-P4 TCTCCCTAAAAAGATCAAGAGCAGATGCAAGAAAGTTTATGTGAAGACAGAATTTGGATT hSHP2-P5 TCTCTCTGAAAAGATCAAGAACAGATGCAAGAAAGTTTATGTGAAGACAGAATTTAGATC hSHP2-P6 TCTCCCTAGAAAGATGAAGAACAGACACAAGAAAGTTTATGTGAAGACAGAATTTGGATT hSHP2-P8 TCTCCCTAAAAAGATCAA--ACTTTCGCAAGAAAGTTTATGTGAAGACCAAATTTGGATT **** ** ****** ** * *** ***************** ***** *** SHP2 TGGAAGGCTTGCAATGTGGTTGACTACCTTTTGATAAGCAAAATTTGAAACCATTTAAAG hSHP2-P3 TGGAAGGCTTGTGTTGTGGTTGACTACCTTTTGATAAGCAAAATTTGAAATCATTTAAAA hSHP2-P4 TGGAAGGCTTACATTGTGGTTGACTACTTTTTGATAAGCAAAATTTGAAACCATTTAAAG hSHP2-P5 TGGAAGGCTTGCATTGTGGTTGACTACCTTTTGATAAGCAAAATTTGAAACCATTTAAAG hSHP2-P6 TGGAAGGCTTGCATTTTTGTTGACTACATTTTGATAAGCAAAATTTGAAACCATTTAAAG hSHP2-P8 TGGAAGGCTTGCATTGTGGTTGACTACCTTTTGATAAGCAAAATTTGAAACCATTTAAAG ********** * * ********* ********************** ******** SHP2 ACCACTGTATTTTAACTCAACAATACCTGCTTCCCAATTACTCATTTCCTCAGATAAGAA hSHP2-P3 ACCACTGTATTTTAACTCAACAATACCTGCTTCCCAATTACTCATTTCCTCAGATAAGAA hSHP2-P4 ACCACTGTATTTTAACTCAACAATACCTGCTTCCCAATTCCTCATTGCCTCAGATAAGAA hSHP2-P5 ATCACTGTATTTTAACTCAAAAATACCTGCTTCCCAATTACTTATTTCCTCAGATAAGAA hSHP2-P6 ACCACTGTG--------------------------------------------------- hSHP2-P8 ATCACTGTATTTTAACTCAACAATACCTGCTTCCCAATTACTCATTTCCTCAGATAAGAA * ****** SHP2 GAAATCATCTCTACAATGTAGACAACATTATATTTTATAGAATTT-GTTTGAAATTGAGG hSHP2-P3 GAAATCATCTCTACAATGTAGACAACGTTGTATTTTATAGAATTTTGTTTTAAATTGAGG hSHP2-P4 GAAATCATCTCCACAATGTAGA---CATTATATTTTATAGAATTTTGTTTTAAATTAAGG hSHP2-P5 GAAATCATCTCTTCAATGTAGACAACATTATATTTTATAGAATTT-GTTTTAAATTGAGG hSHP2-P6 ------------------------------------------------------------ hSHP2-P8 GAAATCATCTCTACTATGTAGA---CATTATATTTTATAGAATTTTGTTTTAAATTGAGG SHP2 AAGCAGTTAAATTGTGCGCTGTATTTTGCAGATTATGGGGATTCAAATTCTAGTAATAGG hSHP2-P3 AAGCAGTTAAATTGTGTGCTATATTTTGCAGATTATGAGGATTCAAATTCTAGTTATAGG hSHP2-P4 AAGCAGTTAAATTGTGTGCTATAGTTTGCAGATTATGGGGATTCAAATTCTAGTTATAGG hSHP2-P5 AAGCAGTTAACTTGTGCACTGTATTTTGCAGATGATGGGGATTCAAATTCTAGTAATAGG hSHP2-P6 ------------------------------------------------------------ hSHP2-P8 AAGCAGTTAAATTGTGTGCTATATTTTGCAGATTATGGGGATTCAAATTCTAGTTACAGG SHP2 CTTTT------TTATTTTTAT--TTTTATACCCTTAACCAGTTTAATTTTTTTTTTCCTC hSHP2-P3 TTTTTGTTGTTTTTTTTTTTTCTTTTTATAACCTTAACCAGTTTAATTTTTTTTT----C hSHP2-P4 CTTTT----------TTTTTTCTTTTTACAAACTTAACCAGTTTAATTTTTTTTT-CCTC hSHP2-P5 CTTTT----------TTTTTTCTTTTTATAACCTTAACCAGTTTAAGTTTTTTTC--CTC hSHP2-P6 ------------------------------------------------------------ hSHP2-P8 CTTTT------TTTTTTTTTTCTTTTTATAACCTTAACCAGTTTTAATTTTTTTTTCCTC SHP2 ATTGTTGGGGATGATGAGAAGAAATGATTTGGGAAAATTAAGTAACAACGACCTAGAAAA hSHP2-P3 ATTGTGGGGCAAGGTAAGAAGAAATGATTTGGGAAAATTAAGTAACAACATCCTAGAAAA hSHP2-P4 ATCGTGGGGGATGATAAGAAGAAATGATTTGGGAAAATTAAGTAAGAACATCCTAGAAAA hSHP2-P5 ATTGTGGGGGATGATAAGAAGAAATGATCTGGGAAAATTAAGTAACGACATCCTAGAAAA hSHP2-P6 ------------------------------------------------------------ hSHP2-P8 ATTGTCGGGGATAA---GAAGAAATGATTTGGGAAGATTAAGTAACAACATCTTAGAAAA SHP2 GTGAGAACAATCTCATTTACCATCATGTATCCAGTAGTGGATAATTCATTTTGATGGCTT hSHP2-P3 GTGAGAACAATCTCATCTACCATCATGTATCCAGTAGTGGATAATTCATTTTGATGGCTT hSHP2-P4 GTGAGAACAATCTCATTTACCATCGTGTATCCAGTAGTGGATAATTCATTTTGATGGCTT hSHP2-P5 GTGAGAACAATCTCATTTACCGTCATGTATCGAGTAGTGTATAATTCATTTTGATGGCTT hSHP2-P6 ------------------------------------------------------------ hSHP2-P8 GTGAGAACAATCTCATTTACCATCATGTATCCAATAGTGGATAATTCATTTTGATGGCTT SHP2 CTATTTTTGGCCAAATGAGAAT-AAGCCAGTGCCTGAGACTGTCAGAAGTTGAC------ hSHP2-P3 CTACTTTTGGCTAAATGAGAATTAAGCCAGTGCCTGAGACTGCCAGAAGCTTACTGGTCT hSHP2-P4 CTATTTTTGGCCAAATGAGAATTAGGCCAGTGCCTGAGACTGTCAGAAGCTGACTGGTCT hSHP2-P5 CTATTTTTGGCCAAATGAGAACTAAGCCAGTGCCTGAGACTGTCAGAAGCTGACTGGTCT hSHP2-P6 ------------------------------------------------------------ hSHP2-P8 CTATTTTTGGCCAAATGAGAATTAAGCTAGGGCCTGAGACTGTCAGAAGCTGACTGGTCT SHP2 --CTTTGCACTGGCATTAAAGAGTCATAGAAAAAA-- hSHP2-P3 ACCTTTGCATTAGCATTAAGGAGTCATAGAAAAAGAA hSHP2-P4 ACCTTTGCATTGGCATTAAAGAGTCATAGAAAAAGAA hSHP2-P5 ACTTTTGCATTGGCATTAAAGAGTCATAGGAAAAG-- hSHP2-P6 ------------------------------------- hSHP2-P8 ACCTTTGCATTGGCATTGAAGAGTCATAGAAAAGG--