CLUSTAL X (1.81) multiple sequence alignment hCD45__PTPRC_ DILL-----ETYKRKIADEG--------------RLFL--AEFQ-SI--- hPTPalpha__PTPRA_ DKLE-----EEINRRMADDN--------------KLFR--EEFN-AL--- hPTPepsilon_PTPRE EHLE-----EEIRIRSADDC--------------KQFR--EEFN-SL--- hPTPlamda__PTPRU_ ADLL-----QHINQMKTAEG--------------YGFK--QEYE-SF--- hPTPkappa__PTPRK_ ADLL-----QHINLMKTSDS--------------YGFK--EEYE-SF--- hPTPmu__PTPRM_ ADLL-----QHITQMKCAEG--------------YGFK--EEYE-SF--- hPTPrho__PTPRT_ ADLL-----QHITQMKRGQG--------------YGFK--EEYE-AL--- hPTPsigma__PTPRS_ ADMA-----EHTERLKANDS--------------LKLS--QEYE-SI--- hPTPdelta__PTPRD_ LELA-----DHIERLKANDN--------------LKFS--QEYE-SI--- hLAR__PTPRF_ TDLA-----DNIERLKANDG--------------LKFS--QEYE-SI--- hPTPgamma__PTPRG_ KQFV-----KHIGELYSNNQ--------------HGFS--EDFE-EV--- hPTPzeta__PTPRZ1_ KHFP-----KHVADLHASSG------------FTEEFETLKEFYQEV--- hSAP1__PTPRH_ EDFA-----DHVRKNERDSN--------------CGFA--DEYQ-QL--- hDEP1__PTPRJ_ ENFE-----AYFKKQQADSN--------------CGFA--EEYE-DL--- hPTPbeta__PTPRB_ NQFE-----GHFMKLQADSN--------------YLLS--KEYE-EL--- hGLEPP1__PTPRO_ DDFD-----AYIKDMAKDSD--------------YKFS--LQFE-EL--- hPTPS31__PTPRQ_ KSFL-----QHVEELCTNNN--------------LKFQ--EEFS-EL--- hHePTP__PTPN7_ HPLT----RWALQRQPPSP---------------KQLE--EEFL-KI--- hPCPTP1__PTPRR_ SRIL---TRSQLRDVVASS---------------HLLQ--SEFM-EI--- hSTEP__PTPN5_ SRVL---QAEELHEKALDP---------------FLLQ--AEFF-EI--- hPTPD1__PTPN21_ ATND-----ERCKILEQRLEQG------------MVF---TEYE-RI--- hPTPD2__PTPN14_ VPMD-----ERFRTLKKKLEEG------------MVF---TEYE-QI--- hMEG1__PTPN4_ HSLR-----ESMIQLAEGLITG------------TVL---TQFD-QL--- hPTPH1__PTPN3_ DTLE-----GSMAQLKKGLESG------------TVL---IQFE-QL--- hMEG2__PTPN9_ MTIQ-----ELVDYVNARQK--------------QGIY--EEYE-DI--- hPTP1B__PTPN1_ MEME-----KEFEQIDKSGS----------------WA--AIYQ-DI--- hTCPTP__PTPN2_ TTIE-----REFEELDTQRR----------------WQ--PLYL-EI--- hPTPBAS__PTPN13_ ANLK-----SVIRVLRGLLDQ--------------GIPS-KELE-NL--- hPTPTyp__PTPN20_ TAIK-----DCLKILEEKTAA-------------YDIM--QEFM-AL--- hBDP1__PTPN18_ DSAR-----SFLERLEARGGRE-----------GAVLA--GEFS-DIQAC hPEST__PTPN12_ RKFI-----QRVQAMKSPDHNG-----------EDNFAR--DFM-RLR-- hHDPTP__PTPN23_ ERLR-----QLQQELEAFRGQL------GDV---GALD--TVWR-EL--- hIA2__PTPRN_ HMIL-----AYMEDHLRNRDR---------------LA--KEWQ-AL--- hIA2beta__PTPRN2_ HMIL-----SYMEDHLKNKNR---------------LE--KEWE-AL--- hSHP2_NP_002825.3_ AEIE-----SRVRELSKLAETT------DKVK--QGFW--EEFE-TL--- cSHP2_Q90687_ AEIE-----SRVRELSKLAETT------DKVK--QGFW--EEFE-TL--- mSHP2_NP_035332.1_ AEIE-----SRVRELSKLAETT------DKVK--QGFW--EEFE-TL--- rSHP2_NP_037220.1_ AEIE-----SRVRELSKLAETT------DKVK--QGFW--EEFE-TL--- hSHP1_NP_002822.2_ ADIE-----NRVLELNKKQES------EDTAK--AGFW--EEFE-SL--- mSHP1_NP_038573.1_ ADIE-----NRVLELNKKQES------EDTRK--AGFW--EEFE-SL--- rSHP1_NP_446360.1_ ADIE-----NRVLELNKKQES------EDTAK--AGFW--EEFE-SL--- xSHP2_A55651_ AEIE-----IRVKELSKPAETA------DKFK--QGFW--EEFE-TL--- fuSHP2_SINFRUT00000136396_ AEIE-----SRVRELSKLAEAT------DKVK--QGFW--EEFE-TL--- zSHP2_AAH45328.1_ AEIE-----SRVRELSKLAEAT------DKVK--QGFW--EEFE-TL--- ryPTPN6b_BAA95198.1_ ---------------------------------------------TL--- hgPTPN6a_BAA95183.1_ -------------------------------------------------- zSHP3_AAH55139.1_ ANIE-----NRVHELNKVADNS------EKPK--QGFW--EEFE-VL--- ryPTPN6c_BAA95199.1_ ---------------------------------------------LL--- ryPTPN6a_BAA95187.1_ -------------------------------------------------- amPTPN6_BAA95174.1_ -------------------------------------------------- anogaSHP2_XP_312507.1_ AGIN-----DRVEQLQRENGGQ------SYGK--GGFW--EEFE-SL--- dmCSW_NP_477131.1_ AGIN-----ARVEQLVKG-----------------GFW--EEFE-SL--- zSHP1_AAH44414.1_ ADIQ-----SRVNQLDQTSEREKMDGADKKIK--AGFW--EEFD-AL--- sPTPN6_BAA82565.1_ -------------------------------------------------- hgPTPN6b_BAA95185_ -------------------------------------------------- fuSHP1_SINFRUT00000156158_ GDIG-----SRVKQLDQTTQKQLE-GESEKSK--AGFW--EEFD-AL--- fuSHP3_SINFRUT00000136154_ ANIE-----NRVRELNKVADNS------EKP--KQGFW--EEFE-VL--- cePTP2_NP_495184.1_ DRFEIIR--RPINPRESMEKTG--------------IS--EEFD-RLS-- hSHP2-P5 AEIK-----SRVRELSKLAETT------DKLK--QGFW--EKFE-TLQ-- hSHP2-P8 AEXX-----SRIRELSKLAETT------XKVK--QGFS--EEFE-TLQ-- hSHP2-P3 AEIE-----SRVRELSKLAETT------DKVR--QGFW--EEFE-TLQ-- hSHP2-P4 AEIE-----SRVRELSKLAETT------DKVK--QGFW--KEFE-TLQ-- hSHP2-P6 AEIE-----SR-VELSKLAETT------DKVQ--QGFW--EEFE-TLQ-- hSHP3__Pseudogene_ LGAW-----RAVCRSSRATDAS------GKAR--QGFW--VEFK-MLQ-- scycaPTPN6_AAM92839.1_ ---------------------------------------------AL--- petmaPTPN6_AAM92838.1_ ---------------------------------------------AL--- hLyPTP__PTPN22_ EILQ-----KFLDEAQSKKIT------------KEEFA--NEFL-KLK-- hCD45__PTPRC_ ----PRVFSKF--PIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAG hPTPalpha__PTPRA_ ----PACPIQA--TCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPD hPTPepsilon_PTPRE ----PSGHIQG--TFELANKEENREKNRYPNILPNDHSRVILSQLDGIPC hPTPlamda__PTPRU_ -----FEG------WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPN hPTPkappa__PTPRK_ -----FEGQSA--SWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPS hPTPmu__PTPRM_ -----FEGQSA--PWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTN hPTPrho__PTPRT_ -----PEGQTA--SWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPH hPTPsigma__PTPRS_ -----DPGQQF--TWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMG hPTPdelta__PTPRD_ -----DPGQQF--TWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPG hLAR__PTPRF_ -----DPGQQF--TWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPG hPTPgamma__PTPRG_ ----QRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDS hPTPzeta__PTPRZ1_ ----QSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDG hSAP1__PTPRH_ ----SLVGHSQ--SQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPG hDEP1__PTPRJ_ ----KLVGISQ--PKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHST- hPTPbeta__PTPRB_ ----KDVGRNQ--SCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPC hGLEPP1__PTPRO_ ----KLIGLDI--PHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEG hPTPS31__PTPRQ_ ----PKFLQDL--SSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPG hHePTP__PTPN7_ ----PSNFVS----PEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQED hPCPTP1__PTPRR_ ----PMNFVD----PKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVTDS hSTEP__PTPN5_ ----PMNFVD----PKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDP hPTPD1__PTPN21_ -L-KKRLVDG---ECSTARLPENAERNRFQDVLPYDDARVELVPTKENN- hPTPD2__PTPN14_ ---PKKKANG---IFSTAALPENAERSRIREVVPYEENRVELIPTKENN- hMEG1__PTPN4_ ----YRKKPGM--TMSCAKLPQNISKNRYRDISPYDATRVILKGN----- hPTPH1__PTPN3_ ----YRKKPGL--AITFAKLPQNLDKNRYKDVLPYDTTRVLLQGN----- hMEG2__PTPN9_ ----RRENPVG--TFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQ hPTP1B__PTPN1_ ----RHEASDF--PCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQED---- hTCPTP__PTPN2_ ----RNESHDY--PHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAE---- hPTPBAS__PTPN13_ -----QELKPLD-QCLIGQTKENRRKNRYKNILPYDATRVPLGDE----- hPTPTyp__PTPN20_ ----ELKNLPG--EFYSGNQPSNREKNRYRDILPYDSTRVPLGKS----- hBDP1__PTPN18_ S--AAWKADGV-CSTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGH hPEST__PTPN12_ RLSTKYRTEKI-YPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQD hHDPTP__PTPN23_ --QDAQEHDAR--GRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGK---- hIA2__PTPRN_ ---CAYQAEPN--TCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSR hIA2beta__PTPRN2_ ---CAYQAEPN--SSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSH hSHP2_NP_002825.3_ ---QQQECKLL-YSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP cSHP2_Q90687_ ---QQQECKLL-YSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP mSHP2_NP_035332.1_ ---QQQECKLL-YSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP rSHP2_NP_037220.1_ ---QQQECKLL-YSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP hSHP1_NP_002822.2_ ---QKQEVKNL-HQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIP mSHP1_NP_038573.1_ ---QKQEVKNL-HQRLEGQRPENKSKNRYKNILPFDHSRVILQGRDSNIP rSHP1_NP_446360.1_ ---QKQEAKNL-HQRLEGQRPENKSKNRYKNILPFDHSRVILQGRDSNIP xSHP2_A55651_ ---QQQECKLL-YSRKEGQRPENKNKNRYKNILPFDHTRVELHDGDPNEQ fuSHP2_SINFRUT00000136396_ ---QQQECKLL-YSRKEGQRAENKNKNRYKNILPFDHTRVVLDDRDPNEP zSHP2_AAH45328.1_ ---QQQECKLL-YSRKEGQRPENKNKNRYKNILPFDHTRVVLTDGDVNEQ ryPTPN6b_BAA95198.1_ ---QQQECKLL-YSRKDGQRQENKYKNRYKNILPFDHTRVVLHDGDVTEP hgPTPN6a_BAA95183.1_ -------------------------------------------------- zSHP3_AAH55139.1_ ---QQQECKLL-YPRKEGQRPENKNKNRYKNILPFDTTRVQIKEADPDVP ryPTPN6c_BAA95199.1_ ---QQQEYKLL-YSRKEGQRIENKSKNRYKNILPFDNTRVRLKEVDESVV ryPTPN6a_BAA95187.1_ -------------------------------------------------- amPTPN6_BAA95174.1_ -------------------------------------------------- anogaSHP2_XP_312507.1_ ---QQQECRHT-FSRREGQRNENRAKNRYKNILPFDHTRVKLKDVDSTVP dmCSW_NP_477131.1_ ----QQDSRDT-FSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSVA zSHP1_AAH44414.1_ ---QKLETKVT-KSRDEGMRPENKSKNRYKNILPFDETRVILENADPNVV sPTPN6_BAA82565.1_ -------------------------------------------------- hgPTPN6b_BAA95185_ -------------------------------------------------- fuSHP1_SINFRUT00000156158_ ---QKQEAKVK-KSREEGQRPENKSKNRYKNILPFNDTRVILKNTDPNVV fuSHP3_SINFRUT00000136154_ ---QQQECKLL-YPRKEGQKPENKSKNRYKNILPFDTTRVEIMETDSDLP cePTP2_NP_495184.1_ -Q-EALPAEQY-LSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPG hSHP2-P5 ----QQECKLL-YSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPDEP hSHP2-P8 ----QQECILL-YGRKEGKRQENKNKNRYKNNLPFDHTRVVLHDGDPNEP hSHP2-P3 ----QQECKLL-YSQKEGRRQENKTKNRYKNILPFDH-RVVLHNGDPSEA hSHP2-P4 ----QQECKLL-YS-KEGQRQENKTKIDIKNILPFDNTKVVLHDGDPNEP hSHP2-P6 ----PQECKLL-YSRKEGQRQENKNKNRYKNILPFDHTRVVLHDDDPNEP hSHP3__Pseudogene_ ----QQECRFL-YPRKEGQSVENKPKNHYKNILPFDATRVILLNEDDSGP scycaPTPN6_AAM92839.1_ ---QKQEDTKK-QSRTEGQRPENKSKNRYKNILPFDNTRVILQIKEEDPP petmaPTPN6_AAM92838.1_ ---QQQECQLL-YSRKEGQRPESKAKNRYKNILPFDHNRVILKDGDQSIP hLyPTP__PTPN22_ -RQTKYKADKT-YPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDED hCD45__PTPRC_ --SNYINASYIDGF-----------KEPRKYIAA-QG----PRD----ET hPTPalpha__PTPRA_ --SDYINASFINGY-----------QEKNKFIAA-QG----PKE----ET hPTPepsilon_PTPRE --SDYINASYIDGY-----------KEKNKFIAA-QG----PKQ----ET hPTPlamda__PTPRU_ --ADYINANYIDGY-----------HRSNHFIAT-QG----PKP----EM hPTPkappa__PTPRK_ --SDYINANYIDGY-----------QRPSHYIAT-QG----PVH----ET hPTPmu__PTPRM_ --SDYINGNYIDGY-----------HRPNHYIAT-QG----PMQ----ET hPTPrho__PTPRT_ --SDYINANYIDGY-----------HRPRHYIAT-QG----PMQ----ET hPTPsigma__PTPRS_ --SDYINANYVDGY-----------RRQNAYIAT-QG----PLP----ET hPTPdelta__PTPRD_ --SDYVNANYIDGY-----------RKQNAYIAT-QG----SLP----ET hLAR__PTPRF_ --SDYINANYIDGY-----------RKQNAYIAT-QG----PLP----ET hPTPgamma__PTPRG_ KHSDYINANYVDGY-----------NKAKAYIAT-QG----PLK----ST hPTPzeta__PTPRZ1_ KLTDYINANYVDGY-----------NRPKAYIAA-QG----PLK----ST hSAP1__PTPRH_ --SDYINASFMPGL-----------WSPQEFIAT-QG----PLP----QT hDEP1__PTPRJ_ --DDYINANYMPGY-----------HSKKDFIAT-QG----PLP----NT hPTPbeta__PTPRB_ --SDYINASYIPGN-----------NFRREYIVT-QG----PLP----GT hGLEPP1__PTPRO_ --ADYINANYIPGY-----------NSPQEYIAT-QG----PLP----ET hPTPS31__PTPRQ_ --SDYINASYISGY-----------LCPNEFIAT-QG----PLP----GT hHePTP__PTPN7_ --GDYINANYIRGYD----------GKEKVYIAT-QG----PMP----NT hPCPTP1__PTPRR_ -LSTYINANYIRGYS----------GKEKAFIAT-QG----PMI----NT hSTEP__PTPN5_ -LSSYINANYIRGYG----------GEEKVYIAT-QG----PIV----ST hPTPD1__PTPN21_ --TGYINASHIKVSVS---------GIEWDYIAT-QG----PLQ----NT hPTPD2__PTPN14_ --TGYINASHIKVVVG---------GAEWHYIAT-QG----PLP----HT hMEG1__PTPN4_ --EDYINANYINMEIPSS-------SIINQYIAC-QG----PLP----HT hPTPH1__PTPN3_ --EDYINASYVNMEIPAA-------NLVNKYIAT-QG----PLP----HT hMEG2__PTPN9_ --TDYINASFMDGY-----------KQKNAYIGT-QG----PLE----NT hPTP1B__PTPN1_ --NDYINASLIKME-----------EAQRSYILT-QG----PLP----NT hTCPTP__PTPN2_ --NDYINASLVDIE-----------EAQRSYILT-QG----PLP----NT hPTPBAS__PTPN13_ --GGYINASFIKIPVG---------KEEFVYIAC-QG----PLP----TT hPTPTyp__PTPN20_ --KDYINASYIRIVNC---------GEEYFYIAT-QG----PLL----ST hBDP1__PTPN18_ --SDYINGNFIRGV-----------DGSLAYIAT-QG----PLP----HT hPEST__PTPN12_ --SDYINANFIKGV-----------YGPKAYVAT-QG----PLA----NT hHDPTP__PTPN23_ --DDYINASCVEGLS----------PYCPPLVAT-QA----PLP----GT hIA2__PTPRN_ --SDYINASPIIEHD----------PRMPAYIAT-QG----PLS----HT hIA2beta__PTPRN2_ --SDYINASPIMDHD----------PRNPAYIAT-QG----PLP----AT hSHP2_NP_002825.3_ -VSDYINANIIMPEFETKCNNS---KPKKSYIAT-QG----CLQ----NT cSHP2_Q90687_ -VSDYINANIIMPEFETKCNNS---KPKKSYIAT-QG----CLQ----NT mSHP2_NP_035332.1_ -VSDYINANIIMPEFETKCNNS---KPKKSYIAT-QG----CLQ----NT rSHP2_NP_037220.1_ -VSDYINANIIMPEFETKCNNS---KPKKSYIAT-QG----CLQ----NT hSHP1_NP_002822.2_ -GSDYINANYIKNQLLGPD------ENAKTYIAS-QG----CLE----AT mSHP1_NP_038573.1_ -GSDYINANYVKNQLLGPD------ENSKTYIAS-QG----CLD----AT rSHP1_NP_446360.1_ -GSDYINANYVKNQLLGPD------ENSKTYIAS-QG----CLD----AT xSHP2_A55651_ -VSDYINANIIMPEFEIKCINP---KPKKRYIAT-QG----CLQ----NT fuSHP2_SINFRUT00000136396_ -GSDYINANIIMPELDVKCNST---KGRKSYIAT-QG----CLQ----NT zSHP2_AAH45328.1_ -GSDYINANLIMPDNEAKSNNS---KLKRSYIAT-QG----CLQ----NT ryPTPN6b_BAA95198.1_ -GSDYINANFILHDIDSNRTTT---KPKKTYIAT-QG----CLH----DT hgPTPN6a_BAA95183.1_ -------------------------------------------------- zSHP3_AAH55139.1_ -GSDYINANYIRSVNEEGR--HM-DEGK-VFIAT-QG----CLQ----NT ryPTPN6c_BAA95199.1_ G-SDYINANNITNG-KNG------DDCKN-YIAT-QG----CLQ----NT ryPTPN6a_BAA95187.1_ -------------------------------------------------- amPTPN6_BAA95174.1_ -------------------------------------------------- anogaSHP2_XP_312507.1_ -GADYINANYIRQPTEAEQNDM---SSSSEYIAT-QG----CLT----NT dmCSW_NP_477131.1_ G-AEYINANYIRLPTDGDLYNM---SSSSEYIAT-QG----CLLTQQVNT zSHP1_AAH44414.1_ G-SDYINANYVINKLMVT-------NPQKTYIAC-QG----CLA----TT sPTPN6_BAA82565.1_ -------------------------------------------------- hgPTPN6b_BAA95185_ -------------------------------------------------- fuSHP1_SINFRUT00000156158_ G-SDYINANYLRNTLWES-------TSQKVYIAS-QG----CLA----ST fuSHP3_SINFRUT00000136154_ -GSDYINANYIRSTHEEGR--HVN-EGK--FIAT-QG----CLQ----NT cePTP2_NP_495184.1_ --SDYINASYVRFENS---------QRTKNFIAT-QG----CLE----TT hSHP2-P5 -VSDYISANTIMPEFETRCNNS---KPKTCYIAT-QG----CQQ----NT hSHP2-P8 -VSDDINANIIMPKFETKCNNS---KPKKSYIAT-QG----CLQ----NM hSHP2-P3 -VSDYINADIIMPEFETKCX--N--LPKKSYIAP-QG----CLQ----NT hSHP2-P4 -VSGYINANIIMPEFETKCNNS---KPKKSYIAT-QG----CLQ----NT hSHP2-P6 -ISDYISANTIMPEFETKCNNS---KPKKSCIAT-QG----CLQ----NM hSHP3__Pseudogene_ G-ADYIRVGVCGAVAPPRGAGP---RGRRVYIAQ--GCLQACLQ----AT scycaPTPN6_AAM92839.1_ -FSDYINANYIKSETMVNRLGK---IIPKTCIAT-QG----CLL----AT petmaPTPN6_AAM92838.1_ -GSDYINANVITADIDNGRVGS---KAPKRYIETTQG----CLQ----NT hLyPTP__PTPN22_ --SSYINANFIKGV-----------YGPKAYIAT-QG----PLS----TT hCD45__PTPRC_ VDDFWRMIWEQKATVIVMVTRCEE-GNRNKCAEYWP--SMEEGTRAFGDV hPTPalpha__PTPRA_ VNDFWRMIWEQNTATIVMVTNLKE-RKECKCAQYWP----DQGCWTYGNI hPTPepsilon_PTPRE VNDFWRMVWEQKSATIVMLTNLKE-RKEEKCHQYWP----DQGCWTYGNI hPTPlamda__PTPRU_ VYDFWRMVWQEHCSSIVMITKLVE-VGRVKCSRYWP-----EDSDTYGDI hPTPkappa__PTPRK_ VYDFWRMIWQEQSACIVMVTNLVE-VGRVKCYKYWP-----DDTEVYGDF hPTPmu__PTPRM_ IYDFWRMVWHENTASIIMVTNLVE-VGRVKCCKYWP-----DDTEIYKDI hPTPrho__PTPRT_ VKDFWRMIWQENSASIVMVTNLVE-VGRVKCVRYWP-----DDTEVYGDI hPTPsigma__PTPRS_ FGDFWRMVWEQRSATIVMMTRLEE-KSRIKCDQYWP----NRGTETYGFI hPTPdelta__PTPRD_ FGDFWRMIWEQRSATVVMMTKLEE-RSRVKCDQYWP----SRGTETHGLV hLAR__PTPRF_ MGDFWRMVWEQRTATVVMMTRLEE-KSRVKCDQYWP----ARGTETCGLI hPTPgamma__PTPRG_ FEDFWRMIWEQNTGIIVMITNLVE-KGRRKCDQYWP----TENSEEYGNI hPTPzeta__PTPRZ1_ AEDFWRMIWEHNVEVIVMITNLVE-KGRRKCDQYWP----ADGSEEYGNF hSAP1__PTPRH_ VGDFWRLVWEQQSHTLVMLTNCME-AGRVKCEHYWP---LDSQPCTHGHL hDEP1__PTPRJ_ LKDFWRMVWEKNVYAIIMLTKCVE-QGRTKCEEYWP----SKQAQDYGDI hPTPbeta__PTPRB_ KDDFWKMVWEQNVHNIVMVTQCVE-KGRVKCDHYWP---ADQDSLYYGDL hGLEPP1__PTPRO_ RNDFWKMVLQQKSQIIVMLTQCNE-KRRVKCDHYWP---FTEEPIAYGDI hPTPS31__PTPRQ_ VGDFWRMVWETRAKTLVMLTQCFE-KGRIRCHQYWP--EDNKPVTVFGDI hHePTP__PTPN7_ VSDFWEMVWQEEVSLIVMLTQLRE--GKEKCVHYWP-----TEEETYGPF hPCPTP1__PTPRR_ VDDFWQMVWQEDSPVIVMITKLKE--KNEKCVLYWP-----EKRGIYGKV hSTEP__PTPN5_ VADFWRMVWQEHTPIIVMITNIEE--MNEKCTEYWP-----EEQVAYDGV hPTPD1__PTPN21_ CQDFWQMVWEQGIAIIAMVTAEEE-GGREKSFRYWPRLGSRHNTVTYGRF hPTPD2__PTPN14_ CHDFWQMVWEQGVNVIAMVTAEEE-GGRTKSHRYWPKLGSKHSSATYGKF hMEG1__PTPN4_ CTDFWQMTWEQGSSMVVMLTTQVE-RGRVKCHQYWP---EPTGSSSYGCY hPTPH1__PTPN3_ CAQFWQVVWDQKLSLIVMLTTLTE-RGRTKCHQYWP---DPPDVMNHGGF hMEG2__PTPN9_ YRDFWLMVWEQKVLVIVMTTRFEE-GGRRKCGQYWP--LEKDSRIRFGFL hPTP1B__PTPN1_ CGHFWEMVWEQKSRGVVMLNRVME-KGSLKCAQYWPQKEEKEMIFEDTNL hTCPTP__PTPN2_ CCHFWLMVWQQKTKAVVMLNRIVE-KESVKCAQYWP-TDDQEMLFKETGF hPTPBAS__PTPN13_ VGDFWQMIWEQKSTVIAMMTQEVE-GEKIKCQRYWP-NILGKTTMVSNRL hPTPTyp__PTPN20_ IDDFWQMVLENNSNVIAMITREME-GGIIKCYHYWP--ISLKKPLELKHF hBDP1__PTPN18_ LLDFWRLVWEFGVKVILMACREIE-NGRKRCERYWA--QEQEPLQTGLFC hPEST__PTPN12_ VIDFWRMIWEYNVVIIVMACREFE-MGRKKCERYWP--LYGEDPITFAPF hHDPTP__PTPN23_ AADFWLMVHEQKVSVIVMLVSEAE-MEKQKVARYFP--TERGQPMVHGAL hIA2__PTPRN_ IADFWQMVWESGCTVIVMLTPLVE-DGVKQCDRYWP---DEGASLYHVYE hIA2beta__PTPRN2_ VADFWQMVWESGCVVIVMLTPLAE-NGVRQCYHYWP---DEGSNLYHIYE hSHP2_NP_002825.3_ VNDFWRMVFQENSRVIVMTTKEVE-RGKSKCVKYWP---DEYALKEYGVM cSHP2_Q90687_ VNDFWRMVFQENSRVIVMTTKEVE-RGKSKCVKYWP---DEYSLKEYGVM mSHP2_NP_035332.1_ VNDFWRMVFQENSRVIVMTTKEVE-RGKSKCVKYWP---DEYALKEYGVM rSHP2_NP_037220.1_ VNDFWRMVFQENSRVIVMTTKEVE-RGKSKCVKYWP---DECALKEYGVM hSHP1_NP_002822.2_ VNDFWQMAWQENSRVIVMTTREVE-KGRNKCVPYWP---EVGMQRAYGPY mSHP1_NP_038573.1_ VNDFWQMAWQENTRVIVMTTREVE-KGRNKCVPYWP---EVGTQRVYGLY rSHP1_NP_446360.1_ VNDFWQMAWQENTRVIVMTTREVE-KGRNKCVPYWP---EVGTQRVYGLY xSHP2_A55651_ VNDFWRMVFQENSRVIVMTTKEVE-RGKSKCVKYWP---DEFALKEYGVM fuSHP2_SINFRUT00000136396_ ISDFWRMVFQENSRVIVMTTKEVE-RGKSKCVKYWP---DMSALKEYGAM zSHP2_AAH45328.1_ ISDFWRMVFQENSRVIVMTTKEVE-RGKSKCVKYWP---DVSALKEYGAM ryPTPN6b_BAA95198.1_ VNDFWRMVFQENSRVIVMTTKEVE-RGKSKCVKYWP---DEMSSKEYGAM hgPTPN6a_BAA95183.1_ -------VYQENSRVIFMTTKEVE-RGRSKCVRYWP---EEGCSKDYGYL zSHP3_AAH55139.1_ VLDFWKMVYQENTHVIVMTTKEME-RGRNKCVRYWP---DLNSTKEFGKV ryPTPN6c_BAA95199.1_ INDFWKMIYQENAHVIVMTTKEIE-RGKCKCVRYWP---DVKTSTEYGMI ryPTPN6a_BAA95187.1_ ---------QENTRIIVMTTREVE-KGRTKCEPYWP---EEQGKKEFGSY amPTPN6_BAA95174.1_ ---------QENTRVIVMTTKEVE-RGKNKCTRYWP---EPGTKKSYGIL anogaSHP2_XP_312507.1_ IQDFWNMIWQENTRVIVMTTKEME-RGKKKCEKYWP---DPQQSKEWGHA dmCSW_NP_477131.1_ VTDFWNMVWQENTRVIVMTTKEYE-RGKEKCARYWP---DEGRSEQFGHA zSHP1_AAH44414.1_ VDDFWQMMWQEDSRVIVMTTREVE-KGRNKCVPYWP--TTEGESKEVGRY sPTPN6_BAA82565.1_ ---------QENSLIIVMTTNEVE-RGRNKCTRYWP---DLDVSKLYGKV hgPTPN6b_BAA95185_ -------IYQEGSRVIVMTTREVE-RGKVKCVRYWP---ELGIEKEFGML fuSHP1_SINFRUT00000156158_ VSDFWQMVWQENTRVIVMTTREVE-KGRNKCVPYWP---DSEEPKDVGQY fuSHP3_SINFRUT00000136154_ VIDFWKMVYQENTHVIVMTTKEVE-RGRNKCVRYWP---DLHGTKEFGKV cePTP2_NP_495184.1_ ISDFWSMVWQENSRVIVMPTMENE--RKEKCARYWP--AEVNKPEVHGDI hSHP2-P5 VNDFWQMKFQENSRVIVMTTKEVD-RGKSKCVKYWP---DEYALKEYGVM hSHP2-P8 VNDFWRMVFQENS-VIVMTTKEVE-RGS-KCVKYWP---DEYALKEYGIM hSHP2-P3 VNDFWRIVFQENSQVIVMTTKEVE-RGKSKCVKYWP---DEYALKEYGIV hSHP2-P4 VNDFWRMVFQ-NSRLIVMTMKEAE-RGKSKCVKYWP---DEYALKEYGVM hSHP2-P6 VNDFCWMVFQENSQVIVMTMKEME-RGKSKCVKYWS---EEDALQEYGVM hSHP3__Pseudogene_ VAAFWATVHQENTRVIVMTTREME-RGRNKCFRDWP---ELPGSQEFGRV scycaPTPN6_AAM92839.1_ VNDFWQMVWQQNSRIIVMTTREVE-KGRNKCVPYWP---DLNSENVYGPF petmaPTPN6_AAM92838.1_ IVDFWRMVYQENSRVIVMTTKEV-ERSRNKCVRYWP---EESCTKDYGYL hLyPTP__PTPN22_ LLDFWRMIWEYSVLIIGMACMEYE-MGKKKCERYWA--EPVEMQLEFGPF . : * : :. hCD45__PTPRC_ VVKINQHKRCPDYIIQKLNIVNKKE--------KATGREVTHIQFTSWPD hPTPalpha__PTPRA_ RVSVEDVTVLVDYTVRKFCIQQVGDMTN-----RKPQRLITQFHFTSWPD hPTPepsilon_PTPRE RVCVEDCVVLVDYTIRKFCIQPQLPDG------CKAPRLVSQLHFTSWPD hPTPlamda__PTPRU_ KIMLVKTETLAEYVVRTFALERRG---------YSARHEVRQFHFTAWPE hPTPkappa__PTPRK_ KVTCVEMEPLAEYVVRTFTLERRG---------YNEIREVKQFHFTGWPD hPTPmu__PTPRM_ KVTLIETELLAEYVIRTFAVEKRG---------VHEIREIRQFHFTGWPD hPTPrho__PTPRT_ KVTLIETEPLAEYVIRTFTVQKKG---------YHEIRELRLFHFTSWPD hPTPsigma__PTPRS_ QVTLLDTIELATFCVRTFSLHKNG---------SSEKREVRQFQFTAWPD hPTPdelta__PTPRD_ QVTLLDTVELATYCVRTFALYKNG---------SSEKREVRQFQFTAWPD hLAR__PTPRF_ QVTLLDTVELATYTVRTFALHKSG---------SSEKRELRQFQFMAWPD hPTPgamma__PTPRG_ IVTLKSTKIHACYTVRRFSIRNTKVKKGQKPKGRQNERVVIQYHYTQWPD hPTPzeta__PTPRZ1_ LVTQKSVQVLAYYTVRNFTLRNTKIKKGSQ-KGRPSGRVVTQYHYTQWPD hSAP1__PTPRH_ RVTLVGEEVMENWTVRELLLLQVEE---------QKTLSVRQFHYQAWPD hDEP1__PTPRJ_ TVAMTSEIVLPEWTIRDFTVKNIQT--------SESH-PLRQFHFTSWPD hPTPbeta__PTPRB_ ILQMLSESVLPEWTIREFKICGEEQ--------LDAHRLIRHFHYTVWPD hGLEPP1__PTPRO_ TVEMISEEEQDDWACRHFRINYAD-----------EMQDVMHFNYTAWPD hPTPS31__PTPRQ_ VITKLMEDVQIDWTIRDLKIERHG-----------DCMTVRQCNFTAWPE hHePTP__PTPN7_ QIRIQDMKECPEYTVRQLTIQYQE-----------ERRSVKHILFSAWPD hPCPTP1__PTPRR_ EVLVISVNECDNYTIRNLVLKQGS-----------HTQHVKHYWYTSWPD hSTEP__PTPN5_ EITVQKVIHTEDYRLRLISLKSGT-----------EERGLKHYWFTSWPD hPTPD1__PTPN21_ KITTRFRTDSGCYATTGLKMKHLLTG---------QERTVWHLQYTDWPE hPTPD2__PTPN14_ KVTTKFRTDSVCYATTGLKVKHLLSG---------QERTVWHLQYTDWPD hMEG1__PTPN4_ QVTCHSEEGNTAYIFRKMTLFNQEKN---------ESRPLTQIQYIAWPD hPTPH1__PTPN3_ HIQCQSEDCTIAYVSREMLVTNTQTG---------EEHTVTHLQYVAWPD hMEG2__PTPN9_ TVTNLGVENMNHYKKTTLEIHNTEER---------QKRQVTHFQFLSWPD hPTP1B__PTPN1_ KLTLISEDIKSYYTVRQLELENLTTQ---------ETREILHFHYTTWPD hTCPTP__PTPN2_ SVKLLSEDVKSYYTVHLLQLENINSG---------ETRTISHFHYTTWPD hPTPBAS__PTPN13_ RLALVRMQQLKGFVVRAMTLEDIQTR---------EVRHISHLNFTAWPD hPTPTyp__PTPN20_ RVFLENYQILQYFIIRMFQVVEKSTG---------TSHSVKQLQFTKWPD hBDP1__PTPN18_ ITLIKEKWLNEDIMLRTLKVTFQK-----------ESRSVYQLQYMSWPD hPEST__PTPN12_ KISCEDEQARTDYFIRTLLLEFQN-----------ESRRLYQFHYVNWPD hHDPTP__PTPN23_ SLALSSVRSTETHVERVLSLQFRDQS---------LKRSLVHLHFPTWPE hIA2__PTPRN_ VNLVSEHIWCEDFLVRSFYLKNVQTQ---------ETRTLTQFHFLSWPA hIA2beta__PTPRN2_ VNLVSEHIWCEDFLVRSFYLKNLQTN---------ETRTVTQFHFLSWYD hSHP2_NP_002825.3_ RVRNVKESAAHDYTLRELKLSKVGQG--------NTERTVWQYHFRTWPD cSHP2_Q90687_ RVRNVKESAAHDYTLRELKLSKVGQG--------NTERTVWQYHFRTWPD mSHP2_NP_035332.1_ RVRNVKESAAHDYTLRELKLSKVGQALLQG----NTERTVWQYHFRTWPD rSHP2_NP_037220.1_ RVRNVRESAAHDYTLRELKLSKVGQG--------NTERTVWQYHFRTWPD hSHP1_NP_002822.2_ SVTNCGEHDTTEYKLRTLQVSPLDNG--------DLIREIWHYQYLSWPD mSHP1_NP_038573.1_ SVTNSREHDTAEYKLRTLQISPLDNG--------DLVREIWHYQYLSWPD rSHP1_NP_446360.1_ SVTNCKEHDTAEYKLRTLQISPLDNG--------DLVREIWHYQYLSWPD xSHP2_A55651_ RVRNVKETPAHDYILRELKLSKVGQG--------NTERAVWQYHFKTWPD fuSHP2_SINFRUT00000136396_ RVRNVRETAAHDYILRELKLSKVGQG--------NTERTVWQYHFRAWPD zSHP2_AAH45328.1_ RVRNVKETMAHDYILRELKLSKVGQG--------NTERTVWQYHFRAWPD ryPTPN6b_BAA95198.1_ RVKNVRENPAHDYILRELKLSKVGQG--------STERTVWQYHFKTWPD hgPTPN6a_BAA95183.1_ RVYNVHESESYDYALRQLELTHVEHA---------ELRIVWQYHFKAWPD zSHP3_AAH55139.1_ CVKNIEEHTAQDYIRRELEVTRLDRR--------EPPRCIWHYQYLSWPD ryPTPN6c_BAA95199.1_ SVRNLEERMAQDYIVRDLEVMRLDWN--------ERPRHVWHYQYLSWPD ryPTPN6a_BAA95187.1_ IVQNLEEREATDYKVRVLEVKPINKS--------TKPRKIHHYQYLSWPD amPTPN6_BAA95174.1_ LIRHLSETNFPDYTLRELEVTKEGEN--------NPPRTIYHYHFKAWPD anogaSHP2_XP_312507.1_ RVRCLSETSTADYTLREFLLSWRGQ----------EDRKIYQYHFQVWPD dmCSW_NP_477131.1_ RIQCVSENSTSDYTLREFLVSWRDQP----------ARRIFHYHFQVWPD zSHP1_AAH44414.1_ VVKLLSEMDAADYKVRVVELTAPHRN--------EAPRKIWHFQYLSWPD sPTPN6_BAA82565.1_ TVCCVKETTKPHYVLREFVVNRNSEDDPAE---KEERRTIFQYHFKAWPD hgPTPN6b_BAA95185_ RVGLVDETAKQEYTLRELSLQHIGFP--------TAVRTIWQYQYKAWPD fuSHP1_SINFRUT00000156158_ VVTINSEREASDYKVRVLKMCPAQQP--------QNSRIIWHYQYISWPD fuSHP3_SINFRUT00000136154_ LVRNVDERPAQDYILRKLEVTRLDRK--------EPLRYIWHYQYLSWPD cePTP2_NP_495184.1_ SLTCTIERKVQRAVSDEVKAELEQEKTNRIMKKGKDTREIRQLQYLTWPD hSHP2-P5 RVRNVKESAAHDYTLRELELSKIGPG--------NMERPVGQYHFRTWPD hSHP2-P8 RVRNIRESTAHNYMLRELKLSKVGQG--------NMERMVWQYHFWTWPD hSHP2-P3 HVRNVKESTTHDYKLRKLKLSKIGQG--------NMERMVWQYHLWTWLY hSHP2-P4 RVRNVKESAAHDYTLRELKLSKAGEG--------NSERTV-QYHFRTWAD hSHP2-P6 CVRNIKGSAVHDYMLRELKFSKVGQAVLQG----NMARTVWQYHFRT-PD hSHP3__Pseudogene_ HMRVLGKGQAQGYCVRELQVWRPGQE--------EPQRTVQHFQYFGWPD scycaPTPN6_AAM92839.1_ TVRHVLEREAIDYKIRELDVTLTEKP-------NSKPRKIFHYQYLSWPD petmaPTPN6_AAM92838.1_ RVYNVRELSLHDHIVRQLELTHVEHL--------DDTRVVWQYHFRAWPD hLyPTP__PTPN22_ SVSCEAEKRKSDYIIRTLKVKFNS-----------ETRTIYQFHYKNWPD . : hCD45__PTPRC_ HGVPED--PHLLLKLRRRVN---------AFSNFFS-----------GPI hPTPalpha__PTPRA_ FGVPFT--PIGMLKFLKKVK---------ACNPQYA-----------GAI hPTPepsilon_PTPRE FGVPFT--PIGMLKFLKKVK---------TLNPVHA-----------GPI hPTPlamda__PTPRU_ HGVPYH--ATGLLAFIRRVK---------ASTPPDA-----------GPI hPTPkappa__PTPRK_ HGVPYH--ATGLLSFIRRVK---------LSNPPSA-----------GPI hPTPmu__PTPRM_ HGVPYH--ATGLLGFVRQVK---------SKSPPSA-----------GPL hPTPrho__PTPRT_ HGVPCY--ATGLLGFVRQVK---------FLNPPEA-----------GPI hPTPsigma__PTPRS_ HGVPEY--PTPFLAFLRRVK---------TCNPPDA-----------GPI hPTPdelta__PTPRD_ HGVPEH--PTPFLAFLRRVK---------TCNPPDA-----------GPM hLAR__PTPRF_ HGVPEY--PTPILAFLRRVK---------ACNPLDA-----------GPM hPTPgamma__PTPRG_ MGVPEY--ALPVLTFVRRSS---------AARMPET-----------GPV hPTPzeta__PTPRZ1_ MGVPEY--SLPVLTFVRKAA---------YAKRHAV-----------GPV hSAP1__PTPRH_ HGVPSS--PDTLLAFWRMLR-------Q-WLDQTMEG----------GPP hDEP1__PTPRJ_ HGVPDT--TDLLINFRYLVR---------D-YMKQSPPE--------SPI hPTPbeta__PTPRB_ HGVPET--TQSLIQFVRTVR---------D-YINRSPGA--------GPT hGLEPP1__PTPRO_ HGVPTANAAESILQFVHMVR---------Q-QATKSK----------GPM hPTPS31__PTPRQ_ HGVPEN--SAPLIHFVKLVR---------ASRAHDT-----------TPM hHePTP__PTPN7_ HQTPES--AGPLLRLVAEVEE------SPE-TAAHP-----------GPI hPCPTP1__PTPRR_ HKTPDS--AQPLLQLMLDVEE-------DRLASQGR-----------GPV hSTEP__PTPN5_ QKTPDR--APPLLHLVREVEE------AAQQEGPHC-----------API hPTPD1__PTPN21_ HGCPED--LKGFLSYLEEIQS---------VRRHTNSTSD--PQSPNPPL hPTPD2__PTPN14_ HGCPED--VQGFLSYLEEIQS---------VRRHTNSMLEG-TKNRHPPI hMEG1__PTPN4_ HGVPDD--SSDFLDFVCHVRN---------KRAGKE-----------EPV hPTPH1__PTPN3_ HGVPDD--SSDFLEFVNYVRS---------LRVDS------------EPL hMEG2__PTPN9_ YGVPSS--AASLIDFLRVVRNQQS--LAVSNMGARSKGQCPE-----PPI hPTP1B__PTPN1_ FGVPES--PASFLNFLFKVR----------ESGSLS------PEH--GPV hTCPTP__PTPN2_ FGVPES--PASFLNFLFKVR----------ESGSLN------PDH--GPA hPTPBAS__PTPN13_ HDTPSQ--PDDLLTFISYMR-----------HIHRS-----------GPI hPTPTyp__PTPN20_ HGTPAS--ADSFIKYIRYARK----------S-HLT-----------GPM hBDP1__PTPN18_ RGVPSS--PDHMLAMVEEARR---------LQGSGP-----------EPL hPEST__PTPN12_ HDVPSS--FDSILDMISLMRK---------YQEHED-----------VPI hHDPTP__PTPN23_ LGLPDS--PSNLLRFIQEVH---------AHYLHQRPLH--------TPI hIA2__PTPRN_ EGTPAS--TRPLLDFRRKVN---------KCYRGRS-----------CPI hIA2beta__PTPRN2_ RGVPSS--SRSLLDFRRKVN---------KCYRGRS-----------CPI hSHP2_NP_002825.3_ HGVPSD--PGGVLDFLEEVH---------HKQESIM-------DA--GPV cSHP2_Q90687_ HGVPSD--PGGVLDFLEEVH---------HKQESIS-------DA--GPV mSHP2_NP_035332.1_ HGVPSD--PGGVLDFLEEVH---------HKQESIV-------DA--GPV rSHP2_NP_037220.1_ HGVPSD--PGGVLDFLEEVH---------HKQESIV-------DA--GPV hSHP1_NP_002822.2_ HGVPSE--PGGVLSFLDQIN---------QRQESLP-------HA--GPI mSHP1_NP_038573.1_ HGVPSE--PGGVLSFLDQIN---------QRQESLP-------HA--GPI rSHP1_NP_446360.1_ HGVPSE--PGGVLSFLDQIN---------QRQESLP-------HA--GPI xSHP2_A55651_ HGVPAD--PGGVLDFLEEVH---------HKQDGIT-------DA--GPV fuSHP2_SINFRUT00000136396_ HGVPTD--PGGVLDFLEEVN---------LKQESIL-------DA--GPI zSHP2_AAH45328.1_ HGVPGD--PGGVLDFLEEVK---------LKQEGIT-------GA--GPI ryPTPN6b_BAA95198.1_ HGVPSD--PGGVLDFLEEVN---------IKQENIP-------EA--GPI hgPTPN6a_BAA95183.1_ HGVPNE--PGGVLNFLDEVN---------RRQDSIP-------DA--GPL zSHP3_AAH55139.1_ HGVPNE--PGGVLSFLEQVN---------RTQSAIP-------ES--GPI ryPTPN6c_BAA95199.1_ HGVPNE--PGGVLSFLDQVN---------RTQQSIP-------DT--GPI ryPTPN6a_BAA95187.1_ HGVPSE--PGGVLSFLEQVN---------RKQESMP-------EA--GPI amPTPN6_BAA95174.1_ HGVPGD--PGCVLNFLHETN---------TKQENIP-------DV--GPM anogaSHP2_XP_312507.1_ HGVPAD--PGCVLNFLQDVN---------TRQAQLQLEGLMP-----GPI dmCSW_NP_477131.1_ HGVPAD--PGCVLNFLQDVN---------TRQSHLAQAGEKP-----GPI zSHP1_AAH44414.1_ HGVPQE--PGGVLSFLDQVN---------RKQEELR----SS--A---PI sPTPN6_BAA82565.1_ HGVPHD--PGAVLGILQDVN---------LQQKELTDEGVKP-----GPI hgPTPN6b_BAA95185_ HGVPGD--LGEVIEFLDEVA---------KRQAYLP-------EA--GPV fuSHP1_SINFRUT00000156158_ HGVPEE--PGGVLSFLAQVN---------AKQDEFA-------KA--GPM fuSHP3_SINFRUT00000136154_ HGVPND--PGGVLWFLEEVN---------RTQSTIP-------DT--GPI cePTP2_NP_495184.1_ HGCPLH--PYAVLNFLEDVD----REYDYFNAQPIAAS----LPQ--GPI hSHP2-P5 HGVPSD--PGVVLDFLEEVY---------HKQGSIT-------DA--GPV hSHP2-P8 HGVPID--PRGVLDFLEEVH---------HKQERIM-------HA--RPV hSHP2-P3 HGVPCD--PKGMLHFLDEVH---------HKQESIM-------DA--GLV hSHP2-P4 HGVLSN--PGGVLDLLEKVH---------HKQESIM-------DA--GPV hSHP2-P6 HGVPSD--PGGMLDFLEEVH---------HKQESIM-------DA--GLV hSHP3__Pseudogene_ YGVRAD--PAGVLGFRDEVN---------RAQSSKP-------RA--GPM scycaPTPN6_AAM92839.1_ HGVPSE--PGGVLSFLEQVN---------NKQDEIRDA---------GPI petmaPTPN6_AAM92838.1_ HGVPNE--PGGVLSFLDEVN---------RRQEGISEE---------GPI hLyPTP__PTPN22_ HDVPSS--IDPILELIWDVRC---------YQEDDS-----------VPI .: hCD45__PTPRC_ VVHCSAGVGRTGTYIGIDAMLEGLEAENK---VDVYGYVVKLRRQRCLMV hPTPalpha__PTPRA_ VVHCSAGVGRTGTFVVIDAMLDMMHTERK---VDVYGFVSRIRAQRCQMV hPTPepsilon_PTPRE VVHCSAGVGRTGTFIVIDAMMAMMHAEQK---VDVFEFVSRIRNQRPQMV hPTPlamda__PTPRU_ VIHCSAGTGRTGCYIVLDVMLDMAECEGV---VDIYNCVKTLCSRRVNMI hPTPkappa__PTPRK_ VVHCSAGAGRTGCYIVIDIMLDMAEREGV---VDIYNCVKALRSRRINMV hPTPmu__PTPRM_ VVHCSAGAGRTGCFIVIDIMLDMAEREGV---VDIYNCVRELRSRRVNMV hPTPrho__PTPRT_ VVHCSAGAGRTGCFIAIDTMLDMAENEGV---VDIFNCVRELRAQRVNLV hPTPsigma__PTPRS_ VVHCSAGVGRTGCFIVIDAMLERIKPEKT---VDVYGHVTLMRSQRNYMV hPTPdelta__PTPRD_ VVHCSAGVGRTGCFIVIDAMLERIKHEKT---VDIYGHVTLMRAQRNYMV hLAR__PTPRF_ VVHCSAGVGRTGCFIVIDAMLERMKHEKT---VDIYGHVTCMRSQRNYMV hPTPgamma__PTPRG_ LVHCSAGVGRTGTYIVIDSMLQQIKDKST---VNVLGFLKHIRTQRNYLV hPTPzeta__PTPRZ1_ VVHCSAGVGRTGTYIVLDSMLQQIQHEGT---VNIFGFLKHIRSQRNYLV hSAP1__PTPRH_ IVHCSAGVGRTGTLIALDVLLRQLQSEGL---LGPFSFVRKMRESRPLMV hDEP1__PTPRJ_ LVHCSAGVGRTGTFIAIDRLIYQIENENT---VDVYGIVYDLRMHRPLMV hPTPbeta__PTPRB_ VVHCSAGVGRTGTFIALDRILQQLDSKDS---VDIYGAVHDLRLHRVHMV hGLEPP1__PTPRO_ IIHCSAGVGRTGTFIALDRLLQHIRDHEF---VDILGLVSEMRSYRMSMV hPTPS31__PTPRQ_ IVHCSAGVGRTGVFIALDHLTQHINDHDF---VDIYGLVAELRSERMCMV hHePTP__PTPN7_ VVHCSAGIGRTGCFIATRIGCQQLKARGE---VDILGIVCQLRLDRGGMI hPCPTP1__PTPRR_ VVHCSAGIGRTGCFIATSIGCQQLKEEGV---VDALSIVCQLRMDRGGMV hSTEP__PTPN5_ IVHCSAGIGRTGCFIATSICCQQLRQEGV---VDILKTTCQLRQDRGGMI hPTPD1__PTPN21_ LVHCSAGVGRTGVVILSEIMIACLEHNEV---LDIPRVLDMLRQQRMMLV hPTPD2__PTPN14_ VVHCSAGVGRTGVLILSELMIYCLEHNEK---VEVPMMLRLLREQRMFMI hMEG1__PTPN4_ VVHCSAGIGRTGVLITMETAMCLIECNQP---VYPLDIVRTMRDQRAMMI hPTPH1__PTPN3_ LVHCSAGIGRTGVLVTMETAMCLTERNLP---IYPLDIVRKMRDQRAMMV hMEG2__PTPN9_ VVHCSAGIGRTGTFCSLDICLAQLEELGT---LNVFQTVSRMRTQRAFSI hPTP1B__PTPN1_ VVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLI hTCPTP__PTPN2_ VIHCSAGIGRSGTFSLVDTCLVLMEKGDD---INIKQVLLNMRKYRMGLI hPTPBAS__PTPN13_ ITHCSAGIGRSGTLICIDVVLGLISQDLD---FDISDLVRCMRLQRHGMV hPTPTyp__PTPN20_ VVHCSAGIGRTGVFLCVDVVFCAIVKDCS---FNIMDIVAQMREQRSGMV hBDP1__PTPN18_ CVHCSAGCGRTGVLCTVDYVRQLLLTQMIPPDFSLFDVVLKMRKQRPAAV hPEST__PTPN12_ CIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAV hHDPTP__PTPN23_ IVHCSSGVGRTGAFALLYAAVQEVEAGNG--IPELPQLVRRMRQQRKHML hIA2__PTPRN_ IVHCSDGAGRTGTYILIDMVLNRMAKGVK--EIDIAATLEHVRDQRPGLV hIA2beta__PTPRN2_ IVHCSDGAGRSGTYVLIDMVLNKMAKGAK--EIDIAATLEHLRDQRPGMV hSHP2_NP_002825.3_ VVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMV cSHP2_Q90687_ VVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMV mSHP2_NP_035332.1_ VVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMV rSHP2_NP_037220.1_ VVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMV hSHP1_NP_002822.2_ IVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMV mSHP1_NP_038573.1_ IVHCSAGIGRTGTIIVIDMLMESISTKGLDCDIDIQKTIQMVRAQRSGMV rSHP1_NP_446360.1_ IVHCSAGIGRTGTIIVIDMLMESVSTKGLDCDIDIQKTIQMVRAQRSGMV xSHP2_A55651_ VVHCSAGIGRTGTFIVIDILIDVIREKGVDCDIDVPKTIQMVRSQRSGMV fuSHP2_SINFRUT00000136396_ AVHCSAGIGRTGTFIVIDILIDVIREKGVDCDIDVPKTIQMVRSQRSGMV zSHP2_AAH45328.1_ VVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMV ryPTPN6b_BAA95198.1_ VVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKSIQMVRSQRSGMV hgPTPN6a_BAA95183.1_ VVHCSAGIGRTGTFIVIDILIDIIRHKGLDCDIDIPKTIQMVRAQRSGMV zSHP3_AAH55139.1_ VVHCSAGIGRTGTIIVIDILIDIINRQGLDCDIDIPKTIQRVRQQRSGMV ryPTPN6c_BAA95199.1_ IVHCSAGIGRTGTIIVIDMLISDISRQGLDCDIDIPKTIQIVRKQRSGMV ryPTPN6a_BAA95187.1_ IVHCSAGIGRTGTIIVIDMLVDKINSQGLDCDIDIQKTIQNVRSQRSGMV amPTPN6_BAA95174.1_ VVHCSAGIGRTGTFIVIDIILNLIKKFGLDCEIDIQKTIQHMRTQRSGMV anogaSHP2_XP_312507.1_ CVHCSAGIGRTGTFIVIDMILDQILRQGHECEIDIQRTIQMVRSQRSGMV dmCSW_NP_477131.1_ CVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLV zSHP1_AAH44414.1_ VIHCSAGIGRTGTIVVIDMLIDSIDAKGLDCDIDIQKCIMMVRDQRSGMV sPTPN6_BAA82565.1_ VVHCSAGIGRTGTFIVIDVIQDLINHQGWDCEIDIQKTIQLVRSQRSGMV hgPTPN6b_BAA95185_ IVHCSAGIGRTGTLIVIDILTDMILHKGPNCSIDIPWVVQWVRSQRSGLV fuSHP1_SINFRUT00000156158_ IIHCSAGIGRTGTIVVIDMILETINTLGA--------------------- fuSHP3_SINFRUT00000136154_ IVHCSA-------------------------------------------- cePTP2_NP_495184.1_ VVHCSAGIGRTGTVLVLDALLNQVKKVGLLCPMDVYKMVKYVRTYRSGLV hSHP2-P5 VVHCSAGIGLTGTFIVIDILTDIVREKGVDCNIDVPKTIQMMRSQRSGMV hSHP2-P8 VVHGSAGIGRTGTYVVIDILTDINREKGVDCNIDVLKTIQMVQSQRSGMV hSHP2-P3 VVPCSAGIGQTGTFIVIDILIDIIREKGVDCEIDVPKTIQMVRSQRSEMV hSHP2-P4 LVHCSAGIGRTGTFIVIDILIDIIREXGVDCDVDVPQTIQMVWSTRSGMV hSHP2-P6 VVHCSAGIGHTGRFIVINSLIDIIREKGINCNIDLLKTIHTVQSQRSGMA hSHP3__Pseudogene_ VVHFSGGIGCTGTIIVIDILVDVIRRQGLDCDTDVPKTIQLVWRQHWGMV scycaPTPN6_AAM92839.1_ VVA----------------------------------------------- petmaPTPN6_AAM92838.1_ VVA----------------------------------------------- hLyPTP__PTPN22_ CIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLIREMRTQRPSLV hCD45__PTPRC_ QVEAQYILIHQALVEYNQA hPTPalpha__PTPRA_ QTDMQYVFIYQALLEHYLA hPTPepsilon_PTPRE QTDMQYTFIYQALLEYYLA hPTPlamda__PTPRU_ QTEEQYIFIHDAILEACLA hPTPkappa__PTPRK_ QTEEQYIFIHDAILEACLA hPTPmu__PTPRM_ QTEEQYVFIHDAILEACLA hPTPrho__PTPRT_ QTEEQYVFVHDAILEACLA hPTPsigma__PTPRS_ QTEDQYSFIHEALLEAVGA hPTPdelta__PTPRD_ QTEDQYIFIHDALLEAVTA hLAR__PTPRF_ QTEDQYVFIHEALLEAATA hPTPgamma__PTPRG_ QTEEQYIFIHDALLEAILA hPTPzeta__PTPRZ1_ QTEEQYVFIHDTLVEAILA hSAP1__PTPRH_ QTEAQYVFLHQCICGSSNA hDEP1__PTPRJ_ QTEDQYVFLNQCVLDIVRA hPTPbeta__PTPRB_ QTECQYVYLHQCVRDVLRA hGLEPP1__PTPRO_ QTEEQYIFIHQCVQLMWMA hPTPS31__PTPRQ_ QNLAQYIFLHQCILDLLSA hHePTP__PTPN7_ QTAEQYQFLHHTLALYAGA hPCPTP1__PTPRR_ QTSEQYEFVHHALCLYESA hSTEP__PTPN5_ QTCEQYQFVHHVMSLYEKA hPTPD1__PTPN21_ QTLCQYTFVYRVLIQFLKA hPTPD2__PTPN14_ QTIAQYKFVYQVLIQFLQA hMEG1__PTPN4_ QTPSQYRFVCEAILKVYEA hPTPH1__PTPN3_ QTSSQYKFVCEAILRVYEA hMEG2__PTPN9_ QTPEQYYFCYKAILEFAEA hPTP1B__PTPN1_ QTADQLRFSYLAVIEGAKA hTCPTP__PTPN2_ QTPDQLRFSYMAIIEGAKA hPTPBAS__PTPN13_ QTEDQYIFCYQVILYVLTA hPTPTyp__PTPN20_ QTKEQYHFCYDIVLEVLRA hBDP1__PTPN18_ QTEEQYRFLYHTVAQMFCA hPEST__PTPN12_ QTKEQYELVHRAIAQLFEA hHDPTP__PTPN23_ QEKLHLRFCYEAVVRHVEA hIA2__PTPRN_ RSKDQFEFALTAVAEEVNA hIA2beta__PTPRN2_ QTKEQFEFALTAVAEEVNA hSHP2_NP_002825.3_ QTEAQYRFIYMAVQHYIET cSHP2_Q90687_ QTEAQYRFIYMAVQHYIET mSHP2_NP_035332.1_ QTEAQYRFIYMAVQHYIET rSHP2_NP_037220.1_ QTEAQYRFIYMAVQHYIET hSHP1_NP_002822.2_ QTEAQYKFIYVAIAQFIET mSHP1_NP_038573.1_ QTEAQYKFIYVAIAQFIET rSHP1_NP_446360.1_ QTEAQYKFIYVAIAQFIET xSHP2_A55651_ QTEAQYRFIYMAVQHYIET fuSHP2_SINFRUT00000136396_ QTEAQYRFIYMAVQHYIET zSHP2_AAH45328.1_ QTEAQYRFIYMAVQHYIET ryPTPN6b_BAA95198.1_ QTEAQYRFIYMAVQHYIET hgPTPN6a_BAA95183.1_ QTEAQFKFVYMAVQQYIET zSHP3_AAH55139.1_ QTEAQYKFIYMAVQQYIDT ryPTPN6c_BAA95199.1_ QTEAQYKFIYMAVQQYIET ryPTPN6a_BAA95187.1_ QTEAQYKFIYMAVTQYIDT amPTPN6_BAA95174.1_ QTEAQYKFVYMAVQHHIET anogaSHP2_XP_312507.1_ QTEAQYKFVYFAVQHYIQT dmCSW_NP_477131.1_ QTEAQYKFVYYAVQHYIQT zSHP1_AAH44414.1_ QTEAQYKFIYLAVLQYVES sPTPN6_BAA82565.1_ QTEQQYKFVYVAIQHFVES hgPTPN6b_BAA95185_ QTESQFRFIYEVVMHFIEN fuSHP1_SINFRUT00000156158_ ------------------- fuSHP3_SINFRUT00000136154_ ------------------- cePTP2_NP_495184.1_ QTEQQYQFLYKALAFYLKN hSHP2-P5 QT-EAYRFIYTAVQHYIET hSHP2-P8 QTETQYRFIYMAVQHYTET hSHP2-P3 QTEAQYRFIYTVVQHHIET hSHP2-P4 QTEARYRFIYMAVQHYIET hSHP2-P6 QTEAQYRFIYMAVQHYIET hSHP3__Pseudogene_ QTEAPYKFTYLALQRHIRG scycaPTPN6_AAM92839.1_ ------------------- petmaPTPN6_AAM92838.1_ ------------------- hLyPTP__PTPN22_ QTQEQYELVYNAVLELFKA