CLUSTAL X (1.81) multiple sequence alignment 1G1H MEMEKEFEQIDKSGS---------WAAIYQDIRHEASDFP--CRVAKLPK hTCPTP__NP_002819__PTPN2 TTIEREFEELDTQRR---------WQPLYLEIRNESHDYP--HRVAKFPE hPTPalpha__NP_002827__PTPRA DKLEEEINRRMADDN-------KLFREEFNALPACPIQAT--CEAASKEE hPTPepsilon__NP_006495__PTPRE EHLEEEIRIRSADDC-------KQFREEFNSLPSGHIQGT--FELANKEE hCD45__NP_002829__PTPRC DILLETYKRKIADEG-------RLFLAEFQSIPRVFSKFP--IKEARKPF hLAR__NP_002831__PTPRF TDLADNIERLKANDG-------LKFSQEYESIDPGQQFT---WENSNLEV hPTPdelta__NP_002830__PTPRD LELADHIERLKANDN-------LKFSQEYESIDPGQQFT---WEHSNLEV hPTPsigma__NP_002841__PTPRS ADMAEHTERLKANDS-------LKLSQEYESIDPGQQFT---WEHSNLEV hPTPrho__NP_573400__PTPRT ADLLQHITQMKRGQG-------YGFKEEYEALPEGQTAS---WDTAKEDE hPTPmu__NP_002836__PTPRM ADLLQHITQMKCAEG-------YGFKEEYESFFEGQSAP---WDSAKKDE hPTPkappa__NP_002835__PTPRK ADLLQHINLMKTSDS-------YGFKEEYESFFEGQSAS---WDVAKKDQ hPTPlamda__NP_005695__PTPRU ADLLQHINQMKTAEG-------YGFKQEYESFFEG-------WDATKKKD hPTPgamma__NP_002832__PTPRG KQFVKHIGELYSNNQ-------HGFSEDFEEVQRCTADMNITAEHSNHPE hPTPzeta__NP_002842__PTPRZ1 KHFPKHVADLHASSG--FTEEFETLKEFYQEVQSCTVDLGITADSSNHPD hSHP1__NP_002822__PTPN6 ADIENRVLELNKKQES-EDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPE hSHP2__NP_002825__PTPN11 AEIESRVRELSKLAETT-DKVKQGFWEEFETLQQQECKLLYSRKEGQRQE hPEST__NP_002826__PTPN12 RKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEE hLyPTP__NP_057051__PTPN22 REILQKFLDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPK hBDP1__NP_055184__PTPN18 DSARSFLERLEARGGREGAVLAGEFSDIQACSAAWKADGVCSTVAGSRPE hPTPBAS___NP_006255___PTPN13 ANLKSVIRVLRGLLDQG------IPSKELENLQELKPLDQ--CLIGQTKE hPTPS31__AR073855__PTPGMC1 KSFLQHVEELCTNNN-------LKFQEEFSELPKFLQDLS--STDADLPW hPTPbeta__NP_002828__PTPRB NQFEGHFMKLQADSN-------YLLSKEYEELKDVGRNQS--CDIALLPE hGLEPP1__NP_109592__PTPRO DDFDAYIKDMAKDSD-------YKFSLQFEELKLIGLDIP--HFAADLPL hDEP1__NP_002834__PTPRJ ENFEAYFKKQQADSN-------CGFAEEYEDLKLVGISQP--KYAAELAE hSAP1__NP_002833__PTPRH EDFADHVRKNERDSN-------CGFADEYQQLSLVGHSQS--QMVASASE hMEG2__NP_002824__PTPN9 MTIQELVDYVNARQKQ-------GIYEEYEDIRRENPVGT--FHCSMSPG hSTEP__NP_116170__PTPN5 EYLLSASRVLQAEELHEKALDPFLLQAEFFEIPMNFVDP----KEYDIPG hPCPTP1__NP_002840__PTPRR EYLQSASRILTRSQLRDVVASSHLLQSEFMEIPMNFVD----PKEIDIPR hHePTP__NP_002823__PTPN7 HFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVS----PEDLDIPG hMEG1__NP_002821__PTPN4 HSLRESMIQLAEGLITG------TVLTQFDQLYRKKPGMT--MSCAKLPQ hPTPH1__NP_002820__PTPN3 DTLEGSMAQLKKGLESG------TVLIQFEQLYRKKPGLA--ITFAKLPQ hPTPD1__NP_008970__PTPN21 ATNDERCKILEQRLEQG------MVFTEYERILKKRLVDGE-CSTARLPE hPTPD2__NP_005392__PTPN14 VPMDERFRTLKKKLEEG------MVFTEYEQIPKKKANGI--FSTAALPE hIA2__NP_002837__PTPRN HMILAYMEDHLRNRDR--------LAKEWQALCAYQAEPNT-CATAQGEG hIA2beta__NP_002838__PTPRN2 HMILSYMEDHLKNKNR--------LEKEWEALCAYQAEPNS-SFVAQREE hPTPTyp__AL050040__PTPN20 TAIKDCLKILEEKTAA------YDIMQEFMALELKNLPGE--FYSGNQPS hHDPTP__NP_056281__PTPN23 ERLRQLQQELEAFRGQLG--DVGALDTVWRELQDAQEHDARGRSIAIARC 1G1H NKNRNRYRDVSPFDHSRIKLHQED------NDYINASLIKME-------E hTCPTP__NP_002819__PTPN2 NRNRNRYRDVSPYDHSRVKLQNAE------NDYINASLVDIE-------E hPTPalpha__NP_002827__PTPRA NKEKNRYVNILPYDHSRVHLTPVEGVPD--SDYINASFINGY-------Q hPTPepsilon__NP_006495__PTPRE NREKNRYPNILPNDHSRVILSQLDGIPC--SDYINASYIDGY-------K hCD45__NP_002829__PTPRC NQNKNRYVDILPYDYNRVELSEINGDAG--SNYINASYIDGF-------K hLAR__NP_002831__PTPRF NKPKNRYANVIAYDHSRVILTSIDGVPG--SDYINANYIDGY-------R hPTPdelta__NP_002830__PTPRD NKPKNRYANVIAYDHSRVLLSAIEGIPG--SDYVNANYIDGY-------R hPTPsigma__NP_002841__PTPRS NKPKNRYANVIAYDHSRVILQPIEGIMG--SDYINANYVDGY-------R hPTPrho__NP_573400__PTPRT NRNKNRYGNIISYDHSRVRLLVLDGDPH--SDYINANYIDGY-------H hPTPmu__NP_002836__PTPRM NRMKNRYGNIIAYDHSRVRLQTIEGDTN--SDYINGNYIDGY-------H hPTPkappa__NP_002835__PTPRK NRAKNRYGNIIAYDHSRVILQPVEDDPS--SDYINANYIDGY-------Q hPTPlamda__NP_005695__PTPRU KVKGSRQEPMPAYDRHRVKLHPMLGDPN--ADYINANYIDGY-------H hPTPgamma__NP_002832__PTPRG NKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGY-------N hPTPzeta__NP_002842__PTPRZ1 NKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGY-------N hSHP1__NP_002822__PTPN6 NKGKNRYKNILPFDHSRVILQGRDSNIPG-SDYINANYIKNQLLGPD--E hSHP2__NP_002825__PTPN11 NKNKNRYKNILPFDHTRVVLHDGDPNEPV-SDYINANIIMPEFETKCNNS hPEST__NP_002826__PTPN12 NVKKNRYKDILPFDHSRVKLTLKTPSQD--SDYINANFIKGV-------Y hLyPTP__NP_057051__PTPN22 NIKKNRYKDILPYDYSRVELSLITSDED--SSYINANFIKGV-------Y hBDP1__NP_055184__PTPN18 NVRKNRYKDVLPYDQTRVILSLLQEEGH--SDYINGNFIRGV-------D hPTPBAS___NP_006255___PTPN13 NRRKNRYKNILPYDATRVPLGDE-------GGYINASFIKIPVG-----K hPTPS31__AR073855__PTPGMC1 NRAKNRFPNIKPYNNNRVKLIADASVPG--SDYINASYISGY-------L hPTPbeta__NP_002828__PTPRB NRGKNRYNNILPYDATRVKLSNVDDDPC--SDYINASYIPGN-------N hGLEPP1__NP_109592__PTPRO NRCKNRYTNILPYDFSRVRLVSMNEEEG--ADYINANYIPGY-------N hDEP1__NP_002834__PTPRJ NRGKNRYNNVLPYDISRVKLSVQTHST---DDYINANYMPGY-------H hSAP1__NP_002833__PTPRH NNAKNRYRNVLPYDWSRVPLKPIHEEPG--SDYINASFMPGL-------W hMEG2__NP_002824__PTPN9 NLEKNRYGDVPCLDQTRVKLTKRSGHTQ--TDYINASFMDGY-------K hSTEP__NP_116170__PTPN5 LVRKNRYKTILPNPHSRVCLTSPDPDDPL-SSYINANYIRGYG------G hPCPTP1__NP_002840__PTPRR HGTKNRYKTILPNPLSRVCLRPKNVTDSL-STYINANYIRGYS------G hHePTP__NP_002823__PTPN7 HASKDRYKTILPNPQSRVCLGRAQSQED--GDYINANYIRGYD------G hMEG1__NP_002821__PTPN4 NISKNRYRDISPYDATRVILKGNE-------DYINANYINMEIPSS---S hPTPH1__NP_002820__PTPN3 NLDKNRYKDVLPYDTTRVLLQGNE-------DYINASYVNMEIP---AAN hPTPD1__NP_008970__PTPN21 NAERNRFQDVLPYDDARVELVPTKENN---TGYINASHIKVSVS-----G hPTPD2__NP_005392__PTPN14 NAERSRIREVVPYEENRVELIPTKENN---TGYINASHIKVVVG-----G hIA2__NP_002837__PTPRN NIKKNRHPDFLPYDHARIKLKVESSPSR--SDYINASPIIEHD------P hIA2beta__NP_002838__PTPRN2 NVPKNRSLAVLTYDHSRVLLKAENSHSH--SDYINASPIMDHD------P hPTPTyp__AL050040__PTPN20 NREKNRYRDILPYDSTRVPLGKSK-------DYINASYIRIVN-----CG hHDPTP__NP_056281__PTPN23 YSLKNRHQDVMPYDSNRVVLRSGK------DDYINASCVEGLS------P .* . *: * *:*.. : 1G1H AQ-RSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYW hTCPTP__NP_002819__PTPN2 AQ-RSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYW hPTPalpha__NP_002827__PTPRA EK-NKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYW hPTPepsilon__NP_006495__PTPRE EK-NKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYW hCD45__NP_002829__PTPRC EP-RKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYW hLAR__NP_002831__PTPRF KQ-NAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYW hPTPdelta__NP_002830__PTPRD KQ-NAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYW hPTPsigma__NP_002841__PTPRS RQ-NAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYW hPTPrho__NP_573400__PTPRT RP-RHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYW hPTPmu__NP_002836__PTPRM RP-NHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYW hPTPkappa__NP_002835__PTPRK RP-SHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYW hPTPlamda__NP_005695__PTPRU RS-NHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYW hPTPgamma__NP_002832__PTPRG KA-KAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYW hPTPzeta__NP_002842__PTPRZ1 RP-KAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYW hSHP1__NP_002822__PTPN6 NA-KTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYW hSHP2__NP_002825__PTPN11 KPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYW hPEST__NP_002826__PTPN12 GP-KAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYW hLyPTP__NP_057051__PTPN22 GP-KAYIATQGPLSTTLLDFWRMIWEYSVLIIGMACMEYEMGKKKCERYW hBDP1__NP_055184__PTPN18 GS-LAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYW hPTPBAS___NP_006255___PTPN13 EE-FVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYW hPTPS31__AR073855__PTPGMC1 CP-NEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYW hPTPbeta__NP_002828__PTPRB FR-REYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYW hGLEPP1__NP_109592__PTPRO SP-QEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW hDEP1__NP_002834__PTPRJ SK-KDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYW hSAP1__NP_002833__PTPRH SP-QEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYW hMEG2__NP_002824__PTPN9 QK-NAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYW hSTEP__NP_116170__PTPN5 EE-KVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEE-MNEKCTEYW hPCPTP1__NP_002840__PTPRR KE-KAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKE-KNEKCVLYW hHePTP__NP_002823__PTPN7 KE-KVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLRE-GKEKCVHYW hMEG1__NP_002821__PTPN4 II-NQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYW hPTPH1__NP_002820__PTPN3 LV-NKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYW hPTPD1__NP_008970__PTPN21 IE-WDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYW hPTPD2__NP_005392__PTPN14 AE-WHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYW hIA2__NP_002837__PTPRN RM-PAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYW hIA2beta__NP_002838__PTPRN2 RN-PAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYW hPTPTyp__AL050040__PTPN20 EE-YFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREMEGGIIKCYHYW hHDPTP__NP_056281__PTPN23 YC-PPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYF : *. .** : . : * * : *: 1G1H PQKEEKEMIFEDTNLKLTLISEDIK-SYYTVRQLELEN-----------L hTCPTP__NP_002819__PTPN2 PTDDQEML-FKETGFSVKLLSEDVK-SYYTVHLLQLEN-----------I hPTPalpha__NP_002827__PTPRA PDQGCWT----YGNIRVSVEDVTVL-VDYTVRKFCIQQVGDM-------T hPTPepsilon__NP_006495__PTPRE PDQGCWT----YGNIRVCVEDCVVL-VDYTIRKFCIQPQLP--------D hCD45__NP_002829__PTPRC PSMEEGT--RAFGDVVVKINQHKRC-PDYIIQKLNIVNK----------K hLAR__NP_002831__PTPRF PARGTET----CGLIQVTLLDTVEL-ATYTVRTFALHK-----------S hPTPdelta__NP_002830__PTPRD PSRGTET----HGLVQVTLLDTVEL-ATYCVRTFALYK-----------N hPTPsigma__NP_002841__PTPRS PNRGTET----YGFIQVTLLDTIEL-ATFCVRTFSLHK-----------N hPTPrho__NP_573400__PTPRT PDDTEVY-----GDIKVTLIETEPL-AEYVIRTFTVQK-----------K hPTPmu__NP_002836__PTPRM PDDTEIY-----KDIKVTLIETELL-AEYVIRTFAVEK-----------R hPTPkappa__NP_002835__PTPRK PDDTEVY-----GDFKVTCVEMEPL-AEYVVRTFTLER-----------R hPTPlamda__NP_005695__PTPRU PEDSDTY-----GDIKIMLVKTETL-AEYVVRTFALER-----------R hPTPgamma__NP_002832__PTPRG PTENSEE----YGNIIVTLKSTKIH-ACYTVRRFSIRNTKVKKGQKGNPK hPTPzeta__NP_002842__PTPRZ1 PADGSEE----YGNFLVTQKSVQVL-AYYTVRNFTLRNTKIKKGSQ---K hSHP1__NP_002822__PTPN6 PEVGMQR---AYGPYSVTNCGEHDT-TEYKLRTLQVSPL----------D hSHP2__NP_002825__PTPN11 PDEYALK---EYGVMRVRNVKESAA-HDYTLRELKLSKV----------G hPEST__NP_002826__PTPN12 PLYGEDP--ITFAPFKISCEDEQAR-TDYFIRTLLLEF------------ hLyPTP__NP_057051__PTPN22 AEPVEMQ--LEFGPFSVSCEAEKRK-SDYIIRTLKVKF------------ hBDP1__NP_055184__PTPN18 AQEQEPL---QTGLFCITLIKEKWLNEDIMLRTLKVTF------------ hPTPBAS___NP_006255___PTPN13 PNILGKTTMV-SNRLRLALVRMQQL-KGFVVRAMTLED-----------I hPTPS31__AR073855__PTPGMC1 PEDNKPV--TVFGDIVITKLMEDVQ-IDWTIRDLKIER------------ hPTPbeta__NP_002828__PTPRB PADQDSL---YYGDLILQMLSESVL-PEWTIREFKICGE----------E hGLEPP1__NP_109592__PTPRO PFTEEPI---AYGDITVEMISEEEQ-DDWACRHFRINY------------ hDEP1__NP_002834__PTPRJ PSKQAQD----YGDITVAMTSEIVL-PEWTIRDFTVKN-----------I hSAP1__NP_002833__PTPRH PLDSQPC---THGHLRVTLVGEEVM-ENWTVRELLLLQ-----------V hMEG2__NP_002824__PTPN9 PLEKDSR--IRFGFLTVTNLGVENM-NHYKKTTLEIHN-----------T hSTEP__NP_116170__PTPN5 PEEQVAY-----DGVEITVQKVIHT-EDYRLRLISLKS------------ hPCPTP1__NP_002840__PTPRR PEKRGIY-----GKVEVLVISVNEC-DNYTIRNLVLKQ------------ hHePTP__NP_002823__PTPN7 PTEEETY-----GPFQIRIQDMKEC-PEYTVRQLTIQY------------ hMEG1__NP_002821__PTPN4 PEPTGSS---SYGCYQVTCHSEEGN-TAYIFRKMTLFN-----------Q hPTPH1__NP_002820__PTPN3 PDPPDVM---NHGGFHIQCQSEDCT-IAYVSREMLVTN-----------T hPTPD1__NP_008970__PTPN21 PRLGSRHNTVTYGRFKITTRFRTDS-GCYATTGLKMKH-----------L hPTPD2__NP_005392__PTPN14 PKLGSKHSSATYGKFKVTTKFRTDS-VCYATTGLKVKH-----------L hIA2__NP_002837__PTPRN PDEGASL----YHVYEVNLVSEHIWCEDFLVRSFYLKN-----------V hIA2beta__NP_002838__PTPRN2 PDEGSNL----YHIYEVNLVSEHIWCEDFLVRSFYLKN-----------L hPTPTyp__AL050040__PTPN20 PISLKKP--LELKHFRVFLENYQIL-QYFIIRMFQVVE-----------K hHDPTP__NP_056281__PTPN23 PTERGQP--MVHGALSLALSSVRST-ETHVERVLSLQF-----------R . : : : 1G1H TTQETREILHFHYTTWPDFGVPES---PASFLNFLFKVR-----ESGSLS hTCPTP__NP_002819__PTPN2 NSGETRTISHFHYTTWPDFGVPES---PASFLNFLFKVR-----ESGSLN hPTPalpha__NP_002827__PTPRA NRKPQRLITQFHFTSWPDFGVPFT---PIGMLKFLKKVK-----ACNPQY hPTPepsilon__NP_006495__PTPRE GCKAPRLVSQLHFTSWPDFGVPFT---PIGMLKFLKKVK-----TLNPVH hCD45__NP_002829__PTPRC EKATGREVTHIQFTSWPDHGVPED---PHLLLKLRRRVN-----AFSNFF hLAR__NP_002831__PTPRF GSSEKRELRQFQFMAWPDHGVPEY---PTPILAFLRRVK-----ACNPLD hPTPdelta__NP_002830__PTPRD GSSEKREVRQFQFTAWPDHGVPEH---PTPFLAFLRRVK-----TCNPPD hPTPsigma__NP_002841__PTPRS GSSEKREVRQFQFTAWPDHGVPEY---PTPFLAFLRRVK-----TCNPPD hPTPrho__NP_573400__PTPRT GYHEIRELRLFHFTSWPDHGVPCY---ATGLLGFVRQVK-----FLNPPE hPTPmu__NP_002836__PTPRM GVHEIREIRQFHFTGWPDHGVPYH---ATGLLGFVRQVK-----SKSPPS hPTPkappa__NP_002835__PTPRK GYNEIREVKQFHFTGWPDHGVPYH---ATGLLSFIRRVK-----LSNPPS hPTPlamda__NP_005695__PTPRU GYSARHEVRQFHFTAWPEHGVPYH---ATGLLAFIRRVK-----ASTPPD hPTPgamma__NP_002832__PTPRG GRQNERVVIQYHYTQWPDMGVPEY---ALPVLTFVRRSS-----AARMPE hPTPzeta__NP_002842__PTPRZ1 GRPSGRVVTQYHYTQWPDMGVPEY---SLPVLTFVRKAA-----YAKRHA hSHP1__NP_002822__PTPN6 NGDLIREIWHYQYLSWPDHGVPSE---PGGVLSFLDQIN-----QRQESL hSHP2__NP_002825__PTPN11 QGNTERTVWQYHFRTWPDHGVPSD---PGGVLDFLEEVH-----HKQESI hPEST__NP_002826__PTPN12 -QNESRRLYQFHYVNWPDHDVPSS---FDSILDMISLMR-----KYQEHE hLyPTP__NP_057051__PTPN22 -NSETRTIYQFHYKNWPDHDVPSS---IDPILELIWDVR-----CYQEDD hBDP1__NP_055184__PTPN18 -QKESRSVYQLQYMSWPDRGVPSS---PDHMLAMVEEAR-----RLQGSG hPTPBAS___NP_006255___PTPN13 QTREVRHISHLNFTAWPDHDTPSQ---PDDLLTFISYMR-----HIHRS- hPTPS31__AR073855__PTPGMC1 -HGDCMTVRQCNFTAWPEHGVPEN---SAPLIHFVKLVR-----ASRAHD hPTPbeta__NP_002828__PTPRB QLDAHRLIRHFHYTVWPDHGVPET---TQSLIQFVRTVR-----DYINRS hGLEPP1__NP_109592__PTPRO -ADEMQDVMHFNYTAWPDHGVPTAN-AAESILQFVHMV------RQQATK hDEP1__NP_002834__PTPRJ QTSESHPLRQFHFTSWPDHGVPDT---TDLLINFRYLVR-----DYMKQS hSAP1__NP_002833__PTPRH EEQKTLSVRQFHYQAWPDHGVPSS---PDTLLAFWRMLR-----QWLDQT hMEG2__NP_002824__PTPN9 EERQKRQVTHFQFLSWPDYGVPSS---AASLIDFLRVVRNQQSLAVSNMG hSTEP__NP_116170__PTPN5 -GTEERGLKHYWFTSWPDQKTPDR---APPLLHLVREVE-----EAAQQE hPCPTP1__NP_002840__PTPRR -GSHTQHVKHYWYTSWPDHKTPDS---AQPLLQLMLDVE-----EDRLAS hHePTP__NP_002823__PTPN7 -QEERRSVKHILFSAWPDHQTPES---AGPLLRLVAEVE-----ESPETA hMEG1__NP_002821__PTPN4 EKNESRPLTQIQYIAWPDHGVPDD---SSDFLDFVCHVR-----NKRAGK hPTPH1__NP_002820__PTPN3 QTGEEHTVTHLQYVAWPDHGVPDD---SSDFLEFVNYVR-----SLRVDS hPTPD1__NP_008970__PTPN21 LTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVR-----RHTNST hPTPD2__NP_005392__PTPN14 LSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRR----RHTNSM hIA2__NP_002837__PTPRN QTQETRTLTQFHFLSWPAEGTPAS---TRPLLDFRRKVN-----KCYRGR hIA2beta__NP_002838__PTPRN2 QTNETRTVTQFHFLSWYDRGVPSS---SRSLLDFRRKVN-----KCYRGR hPTPTyp__AL050040__PTPN20 STGTSHSVKQLQFTKWPDHGTPAS---ADSFIKYIRYAR-----KSHLT- hHDPTP__NP_056281__PTPN23 DQSLKRSLVHLHFPTWPELGLPDS---PSNLLRFIQEVH-----AHYLHQ : : * * : 1G1H PEH------GPVVVHASAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKV hTCPTP__NP_002819__PTPN2 PDH------GPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDD---INIKQV hPTPalpha__NP_002827__PTPRA A--------GAIVVHCSAGVGRTGTFVVIDAMLDMMHTERK---VDVYGF hPTPepsilon__NP_006495__PTPRE A--------GPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQK---VDVFEF hCD45__NP_002829__PTPRC S--------GPIVVHCSAGVGRTGTYIGIDAMLEGLEAENK---VDVYGY hLAR__NP_002831__PTPRF A--------GPMVVHCSAGVGRTGCFIVIDAMLERMKHEKT---VDIYGH hPTPdelta__NP_002830__PTPRD A--------GPMVVHCSAGVGRTGCFIVIDAMLERIKHEKT---VDIYGH hPTPsigma__NP_002841__PTPRS A--------GPIVVHCSAGVGRTGCFIVIDAMLERIKPEKT---VDVYGH hPTPrho__NP_573400__PTPRT A--------GPIVVHCSAGAGRTGCFIAIDTMLDMAENEGV---VDIFNC hPTPmu__NP_002836__PTPRM A--------GPLVVHCSAGAGRTGCFIVIDIMLDMAEREGV---VDIYNC hPTPkappa__NP_002835__PTPRK A--------GPIVVHCSAGAGRTGCYIVIDIMLDMAEREGV---VDIYNC hPTPlamda__NP_005695__PTPRU A--------GPIVIHCSAGTGRTGCYIVLDVMLDMAECEGV---VDIYNC hPTPgamma__NP_002832__PTPRG T--------GPVLVHCSAGVGRTGTYIVIDSMLQQIKDKST---VNVLGF hPTPzeta__NP_002842__PTPRZ1 V--------GPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGT---VNIFGF hSHP1__NP_002822__PTPN6 PHA------GPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKT hSHP2__NP_002825__PTPN11 MDA------GPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKT hPEST__NP_002826__PTPN12 D--------VPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNL hLyPTP__NP_057051__PTPN22 S--------VPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSL hBDP1__NP_055184__PTPN18 P--------EPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIPPDFSLFDV hPTPBAS___NP_006255___PTPN13 ---------GPIITHCSAGIGRSGTLICIDVVLGLISQDLD---FDISDL hPTPS31__AR073855__PTPGMC1 T--------TPMIVHCSAGVGRTGVFIALDHLTQHINDHDF---VDIYGL hPTPbeta__NP_002828__PTPRB PGA------GPTVVHCSAGVGRTGTFIALDRILQQLDSKDS---VDIYGA hGLEPP1__NP_109592__PTPRO SK-------GPMIIHCSAGVGRTGTFIALDRLLQHIRDHEF---VDILGL hDEP1__NP_002834__PTPRJ PPE------SPILVHCSAGVGRTGTFIAIDRLIYQIENENT---VDVYGI hSAP1__NP_002833__PTPRH MEG------GPPIVHCSAGVGRTGTLIALDVLLRQLQSEGL---LGPFSF hMEG2__NP_002824__PTPN9 ARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGT---LNVFQT hSTEP__NP_116170__PTPN5 GPHC-----APIIVHCSAGIGRTGCFIATSICCQQLRQEGV---VDILKT hPCPTP1__NP_002840__PTPRR QGR------GPVVVHCSAGIGRTGCFIATSIGCQQLKEEGV---VDALSI hHePTP__NP_002823__PTPN7 AHP------GPIVVHCSAGIGRTGCFIATRIGCQQLKARGE---VDILGI hMEG1__NP_002821__PTPN4 E--------EPVVVHCSAGIGRTGVLITMETAMCLIECNQP---VYPLDI hPTPH1__NP_002820__PTPN3 E---------PLLVHCSAGIGRTGVLVTMETAMCLTERNLP---IYPLDI hPTPD1__NP_008970__PTPN21 SDPQSPN--PPLLVHCSAGVGRTGVVILSEIMIACLEHNEV---LDIPRV hPTPD2__NP_005392__PTPN14 LEGTKNRH-PPIVVHCSAGVGRTGVLILSELMIYCLEHNEK---VEVPMM hIA2__NP_002837__PTPRN S--------CPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKE--IDIAAT hIA2beta__NP_002838__PTPRN2 S--------CPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKE--IDIAAT hPTPTyp__AL050040__PTPN20 ---------GPMVVHCSAGIGRTGVFLCVDVVFCAIVKDCS---FNIMDI hHDPTP__NP_056281__PTPN23 RPLH-----TPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGI--PELPQL . *.* * **:* 1G1H LLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED- hTCPTP__NP_002819__PTPN2 LLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDL hPTPalpha__NP_002827__PTPRA VSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYN hPTPepsilon__NP_006495__PTPRE VSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHG hCD45__NP_002829__PTPRC VVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKK hLAR__NP_002831__PTPRF VTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQ hPTPdelta__NP_002830__PTPRD VTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQ hPTPsigma__NP_002841__PTPRS VTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQ hPTPrho__NP_573400__PTPRT VRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISR hPTPmu__NP_002836__PTPRM VRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNK hPTPkappa__NP_002835__PTPRK VKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIR hPTPlamda__NP_005695__PTPRU VKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIR hPTPgamma__NP_002832__PTPRG LKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSILI hPTPzeta__NP_002842__PTPRZ1 LKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALLI hSHP1__NP_002822__PTPN6 IQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYG hSHP2__NP_002825__PTPN11 IQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKRKRKGHEYT hPEST__NP_002826__PTPN12 IQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGVNE hLyPTP__NP_057051__PTPN22 IREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIRDKHSGTESQAKHC hBDP1__NP_055184__PTPN18 VLKMRKQRPAAVQTEEQYRFLYHTVAQMFCSTLQNASPHYQNIKENCAPL hPTPBAS___NP_006255___PTPN13 VRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQAEEEQKQQPQLLK---- hPTPS31__AR073855__PTPGMC1 VAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSNQPICFVNYSALQKMD hPTPbeta__NP_002828__PTPRB VHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIYENVN hGLEPP1__NP_109592__PTPRO VSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS- hDEP1__NP_002834__PTPRJ VYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLIYQNTTAMTIY hSAP1__NP_002833__PTPRH VRKMRESRPLMVQTEAQYVFLHQCICGSSNSQPRPQPRRKSRMRMSKTSS hMEG2__NP_002824__PTPN9 VSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVESQ--- hSTEP__NP_116170__PTPN5 TCQLRQDRGGMIQTCEQYQFVHHVMSLYEKQLSHQSPE------------ hPCPTP1__NP_002840__PTPRR VCQLRMDRGGMVQTSEQYEFVHHALCLYESRLSAETVQ------------ hHePTP__NP_002823__PTPN7 VCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP------------ hMEG1__NP_002821__PTPN4 VRTMRDQRAMMIQTPSQYRFVCEAILKVYEEGFVKPLTTSTNK------- hPTPH1__NP_002820__PTPN3 VRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLDPS---------- hPTPD1__NP_008970__PTPN21 LDMLRQQRMMLVQTLCQYTFVYRVLIQFLKSSRLI--------------- hPTPD2__NP_005392__PTPN14 LRLLREQRMFMIQTIAQYKFVYQVLIQFLQNSRLI--------------- hIA2__NP_002837__PTPRN LEHVRDQRPGLVRSKDQFEFALTAVAEEVNAILKALPQ------------ hIA2beta__NP_002838__PTPRN2 LEHLRDQRPGMVQTKEQFEFALTAVAEEVNAILKALPQ------------ hPTPTyp__AL050040__PTPN20 VAQMREQRSGMVQTKEQYHFCYDIVLEVLRKLLTLD-------------- hHDPTP__NP_056281__PTPN23 VRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQVLQRHGVPPPCKPLASASI : * :: : : 1G1H --- hTCPTP__NP_002819__PTPN2 SPA hPTPalpha__NP_002827__PTPRA KIP hPTPepsilon__NP_006495__PTPRE TTT hCD45__NP_002829__PTPRC RDP hLAR__NP_002831__PTPRF VPP hPTPdelta__NP_002830__PTPRD IET hPTPsigma__NP_002841__PTPRS VEP hPTPrho__NP_573400__PTPRT LDP hPTPmu__NP_002836__PTPRM LDP hPTPkappa__NP_002835__PTPRK IDS hPTPlamda__NP_005695__PTPRU IDP hPTPgamma__NP_002832__PTPRG PGV hPTPzeta__NP_002842__PTPRZ1 PGP hSHP1__NP_002822__PTPN6 NIT hSHP2__NP_002825__PTPN11 NIK hPEST__NP_002826__PTPN12 INT hLyPTP__NP_057051__PTPN22 IPE hBDP1__NP_055184__PTPN18 YDD hPTPBAS___NP_006255___PTPN13 --- hPTPS31__AR073855__PTPGMC1 SLD hPTPbeta__NP_002828__PTPRB PEY hGLEPP1__NP_109592__PTPRO --- hDEP1__NP_002834__PTPRJ ENL hSAP1__NP_002833__PTPRH TRT hMEG2__NP_002824__PTPN9 --- hSTEP__NP_116170__PTPN5 --- hPCPTP1__NP_002840__PTPRR --- hHePTP__NP_002823__PTPN7 --- hMEG1__NP_002821__PTPN4 --- hPTPH1__NP_002820__PTPN3 --- hPTPD1__NP_008970__PTPN21 --- hPTPD2__NP_005392__PTPN14 --- hIA2__NP_002837__PTPRN --- hIA2beta__NP_002838__PTPRN2 --- hPTPTyp__AL050040__PTPN20 --- hHDPTP__NP_056281__PTPN23 SQK