PTP-OST - identification of a possible novel human PTP
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Genomic context of the human PTP-OST locus at 1q32.1 

This region in the human genome is syntenic to the locus for rat Osteotesticular PTP (OST-PTP) and mouse Embryonic Stem Cell Phosphatase (PTP-ESP)

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Identification of a second PTP-OST-like sequence fragment (AL354751) at 9q22.31

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Alignment of the predicted nucleotide sequence of human PTP-OST with mouse and orthologs

The human sequence (hPTPOST) has 75% identity to the cDNA of mouse PTP-ESP and rat OSTPTP and is derived from 35 predicted exons.

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Alignment of PTP domains including human PTP-OST

The alignment contains the predicted human sequence of PTP-OST, 37 PTP ‘catalytic’ domains (D1 sequences) and 12 membrane distal domains (D2 sequences) from tandem domain receptor-like PTPs. 

Phylogenetic analysis reveals that PTP-OST belongs to the receptor-like PTP subtype R3; however, PTP-OST is the only R3 subtype member that posses a membrane distal PTP-like domain. (See homology tree as: PDF or Phylip Tree File).

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Predicted full-length proteins for 4 human PTPs

To illustrate the analytical power of current genomic databases and search tools, we have predicted the possible full-length sequence for four human PTPs. These human PTPs (PTPTyp, PTPS31, STEP and HDPTP) was for a long time defined by partial cDNA sequences, although the full-length ortholog sequences had been cloned and characterized in rodents. 

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