PTP Protein Sequence Alignments
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Alignment of human PTP domains

This alignment is color coded according to amino acid sequence conservation. It comprises 49 human PTP domains derived from 37 genes. The alignment has been guided by structural information and optimized by hand. 

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Sequence logos

Domain-specific features detected by comparison of D1 and D2 domains. The Sequence Logos were generated by submitting 62 aligned tandem domain RPTPs to the Blocks server. Only RPTPs with both D1 and D2 (full-length) sequences available were compared. See Methods 2005 for details.

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Alignment of human, worm and fly PTP domains (excl. D2 domains)

This alignment supports our definition of orthologous relationships among human, fly and worm PTPs (published in Andersen et al. Methods 2005). It comprises known human (38) and fly (16) PTPs as well as a select number of worm PTP domains (7), but does not include D2 domains.

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Alignment of human, worm and fly PTP domains (incl. D2 domains)

This alignment supports our definition of orthologous relationships among human, fly and worm PTPs (published in Andersen et al. Methods 2005). It contains 79 PTP domains including 18 D2 domains. In the search & tool section these pre-aligned sequences are used as template for our PTP subtype classification tool.

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Alignment of vertebrate PTP domains (195 sequences)

This alignment is color coded according to amino acid sequence conservation. It comprises 135 PTP ‘Catalytic Domains’ (D1) and 60 Domains (D2) from tandem domain RPTPs. It has been updated from the original alignment of 151 sequences published in Andersen et al MCB 2001.

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Alignment of vertebrate AND invertebrate PTP domains (558 sequences)

This alignment comprises 558 of the 601 PTP domains cataloged in our PTP database. Short fragments and 'problematic' sequences were excluded (i.e. 43 sequences).

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Original alignment of vertebrate PTP domains (151 sequences)

This alignment is color coded according to amino acid sequence conservation. It comprises 151 PTP domains from 113 proteins. This alignment formed the basis of our original subdivision of the PTP family (Andersen et al. MCB 2001) and has been kept for ‘historical’ reasons. 

Click here to retrieve the alignment in other formats (Clustal, MSF, VNTI)

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