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Articles that cite this website:

        1.    Alonso A, Narisawa S, Bogetz J, Tautz L, Hadzic R, Huynh H, Williams S, Gjorloff-Wingren A, Bremer MCD, Holsinger LJ, Millan JL, Mustelin T (2004). VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX. Journal of Biological Chemistry 279:32586-32591.

        2.    Alonso A, Sasin J, Bottini N, Friedberg I, Friedberg I, Osterman A, Godzik A, Hunter T, Dixon J, Mustelin T (2004). Protein tyrosine phosphatases in the human genome. Cell 117:699-711.

        3.     Andersen HS, Olsen OH, Iversen LF, Sorensen ALP, Mortensen SB, Christensen MS, Branner S, Hansen TK, Lau JF, Jeppesen L, Moran EJ, Su J, Bakir F, Judge L, Shahbaz M, Collins T, Vo T, Newman MJ, Ripka WC, Moller NPH (2002). Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B. Journal of Medicinal Chemistry 45:4443-4459.

        4.    Aoki N, Ueno S, Mano H, Yamasaki S, Shiota M, Miyazaki H, Yamaguchi-Aoki Y, Matsuda T, Ullrich A (2004). Mutual regulation of protein-tyrosine phosphatase 20 and protein-tyrosine kinase Tec activities by tyrosine phosphorylation and dephosphorylation. Journal of Biological Chemistry 279:10765-10775.

        5.    Bardelli A, Velculescu VE (2005). Mutational analysis of gene families in human cancer. Current Opinion in Genetics & Development 15:5-12.

        6.    Besco J, Popesco MC, Davuluri RV, Frostholm A, Rotter A (2004). Genomic structure and alternative splicing of murine R2B receptor protein tyrosine phosphatases (PTP kappa, mu, rho and PCP-2). Bmc Genomics 5:1-14.

        7.    Bhaduri A, Sowdhamini R (2003). A genome-wide survey of human tyrosine phosphatases. Protein Engineering 16:881-888.

        8.    Bhaduri A, Ravishankar R, Sowdhamini R (2004). Conserved spatially interacting motifs of protein superfamilies: Application to fold recognition and function annotation of genome data. Proteins-Structure Function and Bioinformatics 54:657-670.

        9.    Bhaduri A, Pugalenthi G, Gupta N, Sowdhamini R (2004). iMOT: an interactive package for the selection of spatially interacting motifs. Nucleic Acids Research 32:W602-W605.

      10.    Bhaduri A, Sowdhamini R (2005). Genome-wide survey of prokaryotic O-protein phosphatases. Journal of Molecular Biology 352:736-752.

      11.    Bialy L, Waldmann H (2005). Inhibitors of protein tyrosine phosphatases: Next-generation drugs? Angewandte Chemie-International Edition 44:3814-3839.

      12.    Boisclair Y, Tremblay ML (2005). Firing up mitochondrial activities with PTPMT1. Molecular Cell 19:291-292.

      13.     Bretscher A, Edwards K, Fehon RG (2002). ERM proteins and merlin: Integrators at the cell cortex. Nature Reviews Molecular Cell Biology 3:586-599.

      14.     Bukczynska P, Klingler-Hoffmann M, Mitchelhill KI, Lam MHC, Ciccomancini M, Tonks NK, Sarcevic B, Kemp BE, Tiganis T (2004). The T-cell protein tyrosine phosphatase is phosphorylated on Ser-304 by cyclin-dependent protein kinases in mitosis. Biochemical Journal 380:939-949.

      15.    Cammer SA, Hoffman BT, Speir JA, Canady MA, Nelson MR, Knutson S, Gallina M, Baxter SM, Fetrow JS (2003). Structure-based active site profiles for genome analysis and functional family subclassification.  Journal of Molecular Biology 334:387-401.

      16.    Cardone L, Carlucci A, Affaitati A, Livigni A, deCristofaro T, Garbi C, Varrone S, Ullrich A, Gottesman ME, Avvedimento EV, Feliciello A (2004). Mitochondrial AKAP121 binds and targets protein tyrosine phosphatase D1, a novel positive regulator of src signaling. Molecular and Cellular Biology 24:4613-4626.

      17.    Carr BI, Wang ZQ, Kar S (2002). K vitamins, PTP antagonism, and cell growth arrest. Journal of Cellular Physiology 193:263-274.

      18.    Chagnon MJ, Uetani N, Tremblay ML (2004). Functional significance of the LAR receptor protein tyrosine phosphatase family in development and diseases. Biochemistry and Cell Biology-Biochimie et Biologie Cellulaire 82:664-675.

      19.    Chang C, Yu TW, Bargmann CI, Tessier-Lavigne M (2004). Inhibition of netrin-mediated axon attraction by a receptor protein tyrosine phosphatase. Science 305:103-106.

      20.    Changela A, Martins A, Shuman S, Mondragon A (2005). Crystal structure of baculovirus RNA triphosphatase complexed with phosphate. Journal of Biological Chemistry 280:17848-17856.

      21.   Chauhan S, Pandey R, Way JF, Sroka TC, Demetriou MC, Kunz S, Cress AE, Mount DW, Miesfeld RL (2003). Androgen regulation of the human FERM domain encoding gene EHM2 in a cell model of steroid-induced differentiation. Biochemical and Biophysical Research Communications 310:421-432.

      22.    Chen WG, Daines MO, Hershey GKK (2004). Turning off signal transducer and activator of transcription (STAT): The negative regulation of STAT signaling. Journal of Allergy and Clinical Immunology 114:476-489.

      23.    Chiarugi P (2005). PTPs versus PTKs: The redox side of the coin. Free Radical Research 39:353-364.

      24.    Chien WW, Tidow N, Williamson EA, Shih LY, Krug U, Kettenbach A, Fermin AC, Roifman CM, Koeffler HP (2003). Characterization of a myeloid tyrosine phosphatase, Lyp, and its role in the Bcr-Abl signal transduction pathway. Journal of Biological Chemistry 278:27413-27420.

      25.    Chin CN, Sachs JN, Engelman DM (2005). Transmembrane homodimerization of receptor-like protein tyrosine phosphatases. Febs Letters 579:3855-3858.

      26.    Chirivi RGS, Dilaver G, van de Vorstenbosch R, Wanschers B, Schepens J, Croes H, Fransen J, Hendriks W (2004). Characterization of multiple transcripts and isoforms derived from the mouse protein tyrosine phosphatase gene Ptprr. Genes to Cells 9:919-933.

      27.    Chiusaroli R, Knobler H, Luxenburg C, Sanjay A, Granot-Attas S, Tiran Z, Miyazaki T, Harmelin A, Baron R, Elson A (2004). Tyrosine phosphatase epsilon is a positive regulator of osteoclast function in vitro and in vivo. Molecular Biology of the Cell 15:234-244.

      28.    Cismasiu VB, Denes SA, Reilander H, Michel H, Szedlacsek SE (2004). The MAM (meprin/A5-protein/PTPmu) domain is a homophilic binding site promoting the lateral dimerization of receptor-like protein-tyrosine phosphatase mu. Journal of Biological Chemistry 279:26922-26931.

      29.    Clahsen T, Lehmann U, Stross C, Hermanns HM, Volkmer-Engert R, Schneider-Mergener J, Heinrich PC, Schaper F (2005). The tyrosine 974 within the LIF-R-chain of the gp130/LIF-R heteromeric receptor complex mediates negative regulation of LIF signalling. Cellular Signalling 17:559-569.

      30.    Cousin W, Courseaux A, Ladoux A, Dani C, Peraldi P (2004). Cloning of hOST-PTP: the only example of a protein-tyrosine-phosphatase the function of which has been lost between rodent and human. Biochemical and Biophysical Research Communications 321:259-265.

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      33.    Drake PG, Peters GH, Andersen HS, Hendriks W, Moller NPH (2003). A novel strategy for the development of selective active-site inhibitors of the protein tyrosine phosphatase-like proteins islet-cell antigen 512 (IA-2) and phogrin (IA-2 beta). Biochemical Journal 373:393-401.

      34.    Dromey JA, Weenink SM, Peters GH, Endl J, Tighe PJ, Todd I, Christie MR (2004). Mapping of epitopes for autoantibodies to the type 1 diabetes autoantigen IA-2 by peptide phage display and molecular modeling: Overlap of antibody and T cell determinants. Journal of Immunology 172:4084-4090.

      35.    Dube N, Bourdeau A, Heinonen KM, Cheng A, Loy AL, Tremblay NL (2005). Genetic ablation of protein tyrosine phosphatase 1B accelerates lymphomagenesis of p53-null mice through the regulation of B-cell development. Cancer Research 65:10088-10095.

      36.    Engelbrecht Y, de Wet H, Horsch K, Langeveldt CR, Hough FS, Hulley PA (2003). Glucocorticoids induce rapid up-regulation of mitogen-activated protein kinase phosphatase-1 and dephosphorylation of extracellular signal-regulated kinase and impair proliferation in human and mouse osteoblast cell lines. Endocrinology 144:412-422.

      37.    Ensslen-Craig SE, Brady-Kalnay SM (2004). Receptor protein tyrosine phosphatases regulate neural development and axon guidance. Developmental Biology 275:12-22.

      38.    Erdmann KS (2003). The protein tyrosine phosphatase PTP-Basophil/Basophil-like - Interacting proteins and molecular functions. European Journal of Biochemistry 270:4789-4798.

      39.    Espagne E, Dupuy C, Huguet E, Cattolico L, Provost B, Martins N, Poirie M, Periquet G, Drezen JM (2004). Genome sequence of a polydnavirus: Insights into symbiotic virus evolution. Science 306:286-289.

      40.    Fodero-Tavoletti MT, Hardy MP, Cornell B, Katsis F, Sadek CM, Mitchell CA, Kemp BE, Tiganis T (2005). Protein tyrosine phosphatase hPTPN20a is targeted to sites of actin polymerization. Biochemical Journal 389:343-354.

      41.    Forrest ARR, Ravasi T, Taylor D, Huber T, Hume DA, Grimmond S (2003). Phosphoregulators: Protein kinases and protein phosphatases of mouse. Genome Research 13:1443-1454.

      42.    Frank C, Burkhardt C, Imhof D, Ringel J, Zschornig O, Wieligmann K, Zacharias M, Bohmer FD (2004). Effective dephosphorylation of Src substrates by SHP-1. Journal of Biological Chemistry 279:11375-11383.

      43.    Freiss G, Vignon F (2004). Protein tyrosine phosphatases and breast cancer. Critical Reviews in Oncology Hematology 52:9-17.

      44.    Fukada M, Kawachi H, Fujikawa A, Noda M (2005). Yeast substrate-trapping system for isolating substrates of protein tyrosine phosphatases: Isolation of substrates for protein tyrosine phosphatase receptor type z. Methods 35:54-63.

      45.    Fukada T, Tonks NK (2003). Identification of YB-1 as a regulator of PTP1B expression: implications for regulation of insulin and cytokine signaling. Embo Journal 22:479-493.

      46.    Galic S, Klingler-Hoffmann M, Fodero-Tavoletti MT, Puryer MA, Meng TC, Tonks NK, Tiganis T (2003). Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP. Molecular and Cellular Biology 23:2096-2108.

      47.    Galic S, Hauser C, Kahn BB, Haj FG, Neel BG, Tonks NK, Tiganis T (2005). Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP. Molecular and Cellular Biology 25:819-829.

      48.    Gee CE, Mansuy IM (2005).  Protein phosphatases and their potential implications in neuroprotective processes. Cellular and Molecular Life Sciences 62:1120-1130.

      49.    Gil-Henn H, Elson A (2003). Tyrosine phosphatase-epsilon activates Src and supports the transformed phenotype of Neu-induced mammary tumor cells. Journal of Biological Chemistry 278:15579-15586.

      50.    Goldstein BJ, Kalyankar M, Wu XD (2005). Redox paradox - Insulin action is facilitated by insulin-stimulated reactive oxygen species with multiple potential signaling targets. Diabetes 54:311-321.

      51.    Goldstein BJ, Mahadev K, Wu XD, Zhu L, Motoshima H (2005). Role of insulin-induced reactive oxygen species in the insulin signaling pathway. Antioxidants & Redox Signaling 7:1021-1031.

      52.    Granot-Attas S, Elson A (2004). Protein tyrosine phosphatase epsilon activates Yes and Fyn in Neu-induced mammary tumor cells. Experimental Cell Research 294:236-243.

      53.    Groen A, Lemeer S, van der Wijk T, Overvoorde J, Heck AJR, Ostman A, Barford D, Slijper M, den Hertog J (2005). Differential oxidation of protein-tyrosine phosphatases. Journal of Biological Chemistry 280:10298-10304.

      54.    Gulati P, Markova B, Gottlicher M, Bohmer FD, Herrlich PA (2004). UVA inactivates protein tyrosine phosphatases by calpain-mediated degradation. Embo Reports 5:812-817.

      55.    Guo F, Nguyen DT, Stuible M, Dube N, Tremblay ML, Chevet E (2004). Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress. Journal of Biological Chemistry 279:49689-49693.

      56.    Guo K, Li J, Tang JP, Koh V, Gan BQ, Zeng Q (2004). Catalytic domain of PRL-3 plays an essential role in tumor metastasis - Formation of PRL-3 tumors inside the blood vessels. Cancer Biology & Therapy 3:945-951.

      57.    Hansen SK, Cancilla MT, Shiau TP, Kung J, Chen T, Erlanson DA (2005). Allosteric inhibition of PTP1B activity by selective modification of a non-active site cysteine residue. Biochemistry 44:7704-7712.

      58.    Hinton SD, Yang DZ, Eckberg WR (2003). Protein tyrosine phosphatases in Chaetopterus egg activation. Development Growth & Differentiation 45:405-415.

      59.    Hoffman BT, Nelson MR, Burdick K, Baxter SM (2004). Protein tyrosine phosphatases: Strategies for distinguishing proteins in a family containing multiple drug targets and anti-targets. Current Pharmaceutical Design 10:1161-1181.

      60.    Hoffman HE, Blair ER, Johndrow JE, Bishop AC (2005). Allele-specific inhibitors of protein tyrosine phosphatases. Journal of the American Chemical Society 127:2824-2825.

      61.    Hulley P, Davison A (2003). Regulation of tyrosine phosphorylation cascades by phosphatases: What the actions of vanadium teach us. Journal of Trace Elements in Experimental Medicine 16:281-290.

      62.    Iversen LF, Andersen HS, Moller KB, Olsen OH, Peters GH, Branner S, Mortensen SB, Hansen TK, Lau J, Ge Y, Holsworth DD, Newman NJ, Moller NPH (2001). Steric hindrance as a basis for structure-based design of selective inhibitors of protein-tyrosine phosphatases. Biochemistry 40:14812-14820.

      63.    Iversen LF, Moller KB, Pedersen AK, Peters GH, Petersen AS, Andersen HS, Branner S, Mortensen SB, Moller NPH (2002). Structure determination of T cell protein-tyrosine phosphatase. Journal of Biological Chemistry 277:19982-19990.

      64.    Jacob ST, Motiwala T (2005). Epigenetic regulation of protein tyrosine phosphatases: potential molecular targets for cancer therapy. Cancer Gene Therapy 12:665-672.

      65.    Jiao JW, Kaur N, Lu B, Reeves SA, Halvorsen SW (2003). Initiation and maintenance of CNTF-Jak/STAT signaling in neurons is blocked by protein tyrosine phosphatase inhibitors. Molecular Brain Research 116:135-146.

      66.    Johnson KG, Van Vactor D (2003). Receptor protein tyrosine phosphatases in nervous system development. Physiological Reviews 83:1-24.

      67.    Kappert K, Peters KG, Bohmer FD, Ostman A (2005). Tyrosine phosphatases in vessel wall signaling. Cardiovascular Research 65:587-598.

      68.    Kellie S, Craggs G, Bird IN, Jones GE (2004). The tyrosine phosphatase DEP-1 induces cytoskeletal rearrangements, aberrant cell-substratum interactions and a reduction in cell proliferation. Journal of Cell Science 117:609-618.

      69.    Kikuchi K (2005). Prospect and retrospect on protein posphatase research. Seikagaku 77:1247-1254.

      70.    Kim SE, Kim SH, Choi KY (2003). Regulation of Drosophila MKP-3 by Drosophila ERK. Apoptosis: from Signaling Pathways to Therapeutic Tools 1010:51-61.

      71.    Kolkman MJM, Streijger F, Linkels M, Bloemen M, Heeren DJ, Hendriks WJAJ, van der Zee CEEM (2004). Mice lacking leukocyte common antigen-related (LAR) protein tyrosine phosphatase domains demonstrate spatial learning impairment in the two-trial water maze and hyperactivity in multiple behavioural tests. Behavioural Brain Research 154:171-182.

      72.    Kraut J, Volohonsky G, Toledano-Katchalski H, Elson A (2002). Nuclear localization of non-receptor protein tyrosine phosphatase epsilon is regulated by its unique N-terminal domain. Experimental Cell Research 281:182-189.

      73.    Larsen M, Tremblay ML, Yamada KM (2003). Phosphatases in cell-matrix adhesion and migration. Nature Reviews Molecular Cell Biology 4:700-711.

      74.    Lehmann U, Schmitz J, Weissenbach M, Sobota RM, Hortner M, Friederichs K, Behrmann I, Tsiaris W, Sasaki A, Schneider-Mergener J, Yoshimura A, Neel BG, Heinrich PC, Schaper F (2003). SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130. Journal of Biological Chemistry 278:661-671.

      75.    Lund IK, Andersen HS, Iversen LF, Olsen OH, Moller KB, Pedersen AK, Ge Y, Holsworth DD, Newman MJ, Axe FU, Moller NPH (2004). Structure-based design of selective and potent inhibitors of protein-tyrosine phosphatase beta. Journal of Biological Chemistry 279:24226-24235.

      76.    Lund IK, Hansen JA, Andersen HS, Moller NPH, Billestrup N (2005). Mechanism of protein tyrosine phosphatase 1B-mediated inhibition of leptin signalling. Journal of Molecular Endocrinology 34:339-351.

      77.    Markova B, Herrlich P, Ronnstrand L, Bohmer FD (2003). Identification of protein tyrosine phosphatases associating with the PDGF receptor. Biochemistry 42:2691-2699.

      78.    Martin MC, Oliver J, Urcelay E, Orozco G, Gomez-Garcia M, Lopez-Nevot MA, Pinero A, Brieva JA, de la Concha EG, Nieto A, Martin J (2005). The functional genetic variation in the PTPN22 gene has a negligible effect on the susceptibility to develop inflammatory bowel disease. Tissue Antigens 66:314-317.

      79.    Martins A, Shuman S (2002). Mutational analysis of baculovirus phosphatase identifies structural residues important for triphosphatase activity in vitro and in vivo. Biochemistry 41:13403-13409.

      80.    Meng TC, Fukada T, Tonks NK (2002). Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo. Molecular Cell 9:387-399.

      81.    Meng TC, Tonks NK (2003). Analysis of the regulation of protein tyrosine phosphatases in vivo by reversible oxidation. Methods Enzymol: Protein Phosphatases 366:304-318.

      82.    Meng TC, Buckley DA, Galic S, Tiganis T, Tonks NK (2004). Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B. Journal of Biological Chemistry 279:37716-37725.

      83.    Montoya GE, Vernot JP, Patarroyo ME (2004). Comparative analysis of CD45 proteins in primate context: owl monkeys vs humans. Tissue Antigens 64:165-172.

      84.    Motiwala T, Kutay H, Ghoshal K, Bai SM, Seimiya H, Tsuruo T, Suster S, Morrison C, Jacob ST (2004). Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer. Proceedings of the National Academy of Sciences of the United States of America 101:13844-13849.

      85.    Muller S, Lamszus K, Nikolich K, Westphal M (2004). Receptor protein tyrosine phosphatase zeta as a therapeutic target for glioblastoma therapy. Expert Opinion on Therapeutic Targets 8:211-220.

      86.    Mustelin T, Tautz L, Page R (2005). Structure of the hematopoietic tyrosine phosphatase (HePTP) catalytic domain: Structure of a KIM phosphatase with phosphate bound at the active site. Journal of Molecular Biology 354:150-163.

      87.    Mustelin T, Vang T, Bottini N (2005). Protein tyrosine phosphatases and the immune response. Nature Reviews Immunology 5:43-57.

      88.    Neel BG, Gu HH, Pao L (2003). The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling. Trends in Biochemical Sciences 28:284-293.

      89.    Niisato K, Fujikawa A, Komai S, Shintani T, Watanabe E, Sakaguchi G, Katsuura G, Manabe T, Noda M (2005). Age-dependent enhancement of hippocampal long-term potentiation and impairment of spatial learning through the Rho-associated kinase pathway in protein tyrosine phosphatase receptor type Z-deficient mice. Journal of Neuroscience 25:1081-1088.

      90.    Oganesian A, Poot M, Daum G, Coats SA, Wright MB, Seifert RA, Bowen-Pope DF (2003). Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation. Proceedings of the National Academy of Sciences of the United States of America 100:7563-7568.

      91.    Orozco G, Sanchez E, Gonzalez-Gay MA, Lopez-Nevot MA, Torres B, Caliz R, Ortego-Centeno N, Jimenez-Alonso J, Pascual-Salcedo D, Balsa A, de Pablo R, Nunez-Roldan A, Gonzalez-Escribano MF, Martin J (2005). Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus. Arthritis and Rheumatism 52:219-224.

      92.    Pagliarini DJ, Worby CA, Dixon JE (2004). A PTEN-like phosphatase with a novel substrate specificity. Journal of Biological Chemistry 279:38590-38596.

      93.   Pagliarini DJ, Wiley SE, Kimple ME, Dixon JR, Kelly P, Worby CA, Casey PJ, Dixon JE (2005). Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells. Molecular Cell 19:197-207.

      94.    Pasquali C, Curchod ML, Walchli S, Espanel X, Guerrier M, Arigoni F, Strous G, van Huijsduijnen RH (2003 Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor. Molecular Endocrinology 17:2228-2239.

      95.    Paul S, Lombroso PJ (2003). Receptor and nonreceptor protein tyrosine phosphatases in the nervous system. Cellular and Molecular Life Sciences 60:2465-2482.

      96.    Pedersen AK, Guo XL, Moller KB, Peters GH, Andersen HS, Kastrup JS, Mortensen SB, Iversen LF, Zhang ZY, Moller NPH (2004). Residue 182 influences the second step of protein-tyrosine phosphatase-mediated catalysis. Biochemical Journal 378:421-433.

      97.    Peisach E, Selengut JD, Dunaway-Mariano D, Allen KN (2004). X-ray crystal structure of the hypothetical phosphotyrosine phosphatase MDP-1 of the haloacid dehalogenase superfamily. Biochemistry 43:12770-12779.

      98.    Persson C, Engstrom U, Mowbray SL, Ostman A (2002). Primary sequence determinants responsible for site-selective dephosphorylation of the PDGF beta-receptor by the receptor-like protein tyrosine phosphatase DEP-1. Febs Letters 517:27-31.

      99.    Persson C, Sjoblom T, Groen A, Kappert K, Engstrom U, Hellman U, Heldin CH, den Hertog J, Ostman A (2004). Preferential oxidation of the second phosphatase domain of receptor-like PTP-alpha revealed by an antibody against oxidized protein tyrosine phosphatases. Proceedings of the National Academy of Sciences of the United States of America 101:1886-1891.

    100.    Persson C, Kappert K, Engstrom U, Ostman A, Sjoblom T (2005). An antibody-based method for monitoring in vivo oxidation of protein tyrosine phosphatases. Methods 35:37-43.

    101.    Peters GH, Iversen LF, Andersen HS, Moller NPH, Olsen OH (2004). Residue 259 in protein-tyrosine phosphatase PTPlB and PTP alpha determines the flexibility of glutamine 262. Biochemistry 43:8418-8428.

    102.    Petrone A, Battaglia F, Wang C, Dusa A, Su J, Zagzag D, Bianchi R, Casaccia-Bonnefil P, Arancio O, Sap J (2003). Receptor protein tyrosine phosphatase alpha is essential for hippocampal neuronal migration and long-term potentiation. Embo Journal 22:4121-4131.

    103.    Pils B, Schultz J (2004). Evolution of the multifunctional protein tyrosine phosphatase family. Molecular Biology and Evolution 21:625-631.

    104.    Poole AW, Jones ML (2005). A SHPing tale: Perspectives on the regulation of SHP-1 and SHP-2 tyrosine phosphatases by the C-terminal tail. Cellular Signalling 17:1323-1332.

    105.    Provost B, Varricchio P, Arana E, Espagne E, Falabella P, Huguet E, La Scaleia R, Cattolico L, Poirie M, Malva C, Olszewski JA, Pennacchio F, Drezen JM (2004). Bracoviruses contain a large multigene family coding for protein tyrosine phosphatases. Journal of Virology 78:13090-13103.

    106.    Rebay I, Silver SJ, Tootle TL (2005). New vision from Eyes absent: transcription factors as enzymes. Trends in Genetics 21:163-171.

    107.    Reth M (2002). Hydrogen peroxide as second messenger in lymphocyte activation. Nature Immunology 3:1129-1134.

    108.    Roskoski R (2005). Src kinase regulation by phosphorylation and dephosphorylation. Biochemical and Biophysical Research Communications 331:1-14.

    109.    Rueda B, Nunez C, Orozco G, Lopez-Nevot MA, de la Concha EG, Martin J, Urcelay E (2005). C1858T functional variant of PTPN22 gene is not associated with celiac disease genetic predisposition. Human Immunology 66:848-852.

    110.    Sajnani-Perez G, Chilton JK, Aricescu AR, Haj F, Stoker AW (2003). Isoform-specific binding of the tyrosine phosphatase PTP sigma to a ligand in developing muscle. Molecular and Cellular Neuroscience 22:37-48.

    111.    Salmeen A, Barford D (2005). Functions and mechanisms of redox regulation of cysteine-based phosphatases. Antioxidants & Redox Signaling 7:560-577.

    112.    Salvi M, Stringaro A, Brunati AM, Agostinelli E, Arancia G, Clari G, Toninello A (2004). Tyrosine phosphatase activity in mitochondria: presence of Shp-2 phosphatase in mitochondria. Cellular and Molecular Life Sciences 61:2393-2404.

    113.    Scapin G, Patel SB, Becker JW, Wang QP, Desponts C, Waddleton D, Skorey K, Cromlish W, Bayly C, Therien M, Gauthier JY, Li CS, Lau CK, Ramachandran C, Kennedy BP, Asante-Appiah E (2003). The structural basis for the selectivity of benzotriazole inhibitors of PTP1B. Biochemistry 42:11451-11459.

    114.    Seifert RA, Coats SA, Oganesian A, Wright MB, Dishmon M, Booth CJ, Johnson RJ, Alpers CE, Bowen-Pope DF (2003). PTPRQ is a novel phosphatidylinositol phosphatase that can be expressed as a cytoplasmic protein or as a subcellularly localized receptor-like protein. Experimental Cell Research 287:374-386.

    115.    Singh NN, Androphy EJ, Singh RN (2004). The regulation and regulatory activities of alternative splicing of the SMN gene. Critical Reviews in Eukaryotic Gene Expression 14:271-285.

    116.    Stern DF (2005). Phosphoproteomics for oncology discovery and treatment. Expert Opinion on Therapeutic Targets 9:851-860.

    117.    Stoker A (2005). Methods for identifying extracellular ligands of RPTPs. Methods 35:80-89.

    118.    Tartaglia M, Gelb BD (2005). Germ-line and somatic PTPN11 mutations in human disease. European Journal of Medical Genetics 48:81-96.

    119.    Tiganis T (2002). Protein tyrosine phosphatases: Dephosphorylating the epidermal growth factor receptor. Iubmb Life 53:3-14.

    120.    Tiran Z, Peretz A, Attali B, Elson A (2003). Phosphorylation-dependent regulation of Kv2.1 channel activity at tyrosine 124 by Src and by protein-tyrosine phosphatase epsilon. Journal of Biological Chemistry 278:17509-17514.

    121.    Tobin JF, Tam S (2002). Recent advances in the development of small molecule inhibitors of PTP1B for the treatment of insulin resistance and type 2 diabetes. Current Opinion in Drug Discovery & Development 5:500-512.

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    123.    Toledano-Katchalski H, Kraut J, Sines T, Granot-Attas S, Shohat G, Gil-Henn H, Yung Y, Elson A (2003). Protein tyrosine phosphatase epsilon inhibits signaling by mitogen-activated protein kinases. Molecular Cancer Research 1:541-550.

    124.    Tonks NK (2003). PTP1B: From the sidelines to the front lines! Febs Letters 546:140-148.

    125.    Tootle TL, Silver SJ, Davies EL, Newman V, Latek RR, Mills IA, Selengut JD, Parlikar BEW, Rebay I (2003). The transcription factor Eyes absent is a protein tyrosine phosphatase. Nature 426:299-302.

    126.    Touyz RM, Tabet F, Schiffrin EL (2003). Redox-dependent signalling by angiotensin II and vascular remodelling in hypertension. Clinical and Experimental Pharmacology and Physiology 30:860-866.

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    128.    Touyz RM (2005). Reactive oxygen species as mediators of calcium signaling by angiotensin II: Implications in vascular physiology and pathophysiology. Antioxidants & Redox Signaling 7:1302-1314.

    129.    van der Wijk T, Blanchetot C, Overvoorde J, den Hertog J (2003). Redox-regulated rotational coupling of receptor protein-tyrosine phosphatase alpha dimers. Journal of Biological Chemistry 278:13968-13974.

    130.    van der Wijk T, Overvoorde J, den Hertog J (2004). H2O2-induced intermolecular disulfide bond formation between receptor protein-tyrosine phosphatases. Journal of Biological Chemistry 279:44355-44361.

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    132.    van Huijsduijnen RH, Sauer WHB, Bombrun A, Swinnen D (2004). Prospects for inhibitors of protein tyrosine phosphatase 1B as antidiabetic drugs. Journal of Medicinal Chemistry 47:4142-4146.

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    134.    Villa F, Deak M, Bloomberg GB, Alessi DR, van Aalten DMF (2005). Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer - Evidence for a second phosphotyrosine substrate recognition pocket. Journal of Biological Chemistry 280:8180-8187.

    135.    Wabakken T, Hauge H, Funderud S, Aasheim HC (2002). Characterization, expression and functional aspects of a novel protein tyrosine phosphatase epsilon isoform. Scandinavian Journal of Immunology 56:276-285.

    136.    Walchli S, Espanel X, Harrenga A, Rossi M, Cesareni G, van Huijsduijnen RH (2004). Probing protein-tyrosine phosphatase substrate specificity using a phosphotyrosine-containing phage library. Journal of Biological Chemistry 279:311-318.

    137.    Walchli S, Espanel X, van Huijsduijnen RH (2005). Sap-1/PTPRH activity is regulated by reversible dimerization. Biochemical and Biophysical Research Communications 331:497-502.

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    144.    Wolstencroft KJ, Stevens R, Tabernero L, Brass A (2005). PhosphaBase: An ontology-driven database resource for protein phosphatases. Proteins-Structure Function and Bioinformatics 58:290-294.

    145.    Xie LP, Zhang YL, Zhang ZY (2002). Design and characterization of an improved protein tyrosine phosphatase substrate-trapping mutant. Biochemistry 41:4032-4039.

    146.    Zeng Q, Dong JM, Guo K, Li J, Tan HX, Koh V, Pallen CJ, Manser E, Hong W (2003). PRL-3 and PRL-1 promote cell migration, invasion, and metastasis. Cancer Research 63:2716-2722.

    147.    Zeng WY, Wang YH, Zhang YC, Yang WL, Shi YY (2003). Functional significance of conserved glycine 127 in a human dual-specificity protein tyrosine phosphatase. Biochemistry-Moscow 68:634-638.

    148.    Zhang ZY (2003). Mechanistic studies on protein tyrosine phosphatases. Progress in Nucleic Acid Research and Molecular Biology, Vol 73 73:171-220.

    149.    Zhao RX, Xing S, Li Z, Fu XQ, Li QS, Krantz SB, Zhao ZHJ (2005). Identification of an acquired JAK2 mutation in Polycythemia vera. Journal of Biological Chemistry 280:22788-22792.

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                                                       (Updated December 2005)