Cα-regiovariation score analysis (CARVS)
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CARVS on PTP subgroups 

Identification of conserved area of surface of PTP domain including two areas opposite active site. Areas of conservation (blue, most conserved; red, least conserved) represent Cα-regiovariation score values of 37 aligned human PTP catalytic domains

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Substrate selectivity determining regions 

Non-conserved amino acids in the proximity of the PTP active site are involved in the recognition of peptide substrates and non-peptide inhibitors

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The HCSAGXGR and IAXQGP motifs reside within the most highly conserved microenvironment of the PTP structure 

Peaks identify residues located within a highly conserved three-dimensional space of the PTP structure

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